                         SEQUENCE LISTING

<110>  Debiopharm International S.A.
 
<120>  Combination Therapy

<130>  DPH 136 - PCT

<140>  PCT/IB2018/001445
<141>  2018-12-18

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc-feature
<222>  (1)..(1)
<223>  Xaa is pyroGlu

<220>
<221>  misc-feature
<222>  (10)..(10)
<223>  Xaa is Gly-NH2

<400>  1

Xaa His Trp Ser Tyr Gly Leu Arg Pro Xaa 
1               5                   10  


<210>  2
<211>  9
<212>  PRT
<213>  Synthetic


<220>
<221>  misc-feature
<222>  (1)..(1)
<223>  Xaa is pyroGlu

<220>
<221>  misc-feature
<222>  (6)..(6)
<223>  Xaa is D-Leu

<220>
<221>  misc-feature
<222>  (9)..(9)
<223>  Xaa is Pro-NHEt

<400>  2

Xaa His Trp Ser Tyr Xaa Leu Arg Xaa 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Synthetic


<220>
<221>  misc-feature
<222>  (1)..(1)
<223>  Xaa is pyroGlu

<220>
<221>  misc-feature
<222>  (6)..(6)
<223>  Xaa is D-Ser(tBu)

<220>
<221>  misc-feature
<222>  (9)..(9)
<223>  Xaa is Pro-NHEt

<400>  3

Xaa His Trp Ser Tyr Xaa Leu Arg Xaa 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Synthetic


<220>
<221>  misc-feature
<222>  (1)..(1)
<223>  Xaa is Oxo-Pro

<220>
<221>  misc-feature
<222>  (6)..(6)
<223>  Xaa is Ntbenzyl-D-His

<220>
<221>  misc-feature
<222>  (9)..(9)
<223>  Xaa is N-Et-L-prolinamide

<400>  4

Xaa His Trp Ser Tyr Xaa Leu Arg Xaa 
1               5                   


<210>  5
<211>  10
<212>  PRT
<213>  Synthetic


<220>
<221>  misc-feature
<222>  (1)..(1)
<223>  Xaa is pyroGlu

<220>
<221>  misc-feature
<222>  (6)..(6)
<223>  Xaa is D-Ser(tBu)

<220>
<221>  misc-feature
<222>  (10)..(10)
<223>  Xaa is AzaGly-NH2

<400>  5

Xaa His Trp Ser Tyr Xaa Leu Arg Pro Xaa 
1               5                   10  


<210>  6
<211>  9
<212>  PRT
<213>  Synthetic


<220>
<221>  misc-feature
<222>  (1)..(1)
<223>  Xaa is pyroGlu

<220>
<221>  misc-feature
<222>  (6)..(6)
<223>  Xaa is D-Trp

<220>
<221>  misc-feature
<222>  (9)..(9)
<223>  Xaa is Pro-NHEt

<400>  6

Xaa His Trp Ser Tyr Xaa Leu Arg Xaa 
1               5                   


<210>  7
<211>  10
<212>  PRT
<213>  Synthetic


<220>
<221>  misc-feature
<222>  (1)..(1)
<223>  Xaa is Oxo-Pro

<220>
<221>  misc-feature
<222>  (6)..(6)
<223>  Xaa is 3-(2-naphtyl)-D-Ala

<220>
<221>  misc-feature
<222>  (10)..(10)
<223>  Xaa is Gly-NH2

<400>  7

Xaa His Trp Ser Tyr Xaa Leu Arg Pro Xaa 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Synthetic


<220>
<221>  misc-feature
<222>  (1)..(1)
<223>  Xaa is pyroGlu

<220>
<221>  misc-feature
<222>  (6)..(6)
<223>  Xaa is D-Trp

<220>
<221>  misc-feature
<222>  (10)..(10)
<223>  Xaa is Gly-NH2

<400>  8

Xaa His Trp Ser Tyr Xaa Leu Arg Pro Xaa 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Synthetic


<220>
<221>  misc-feature
<222>  (1)..(1)
<223>  Xaa is N-acetyl-3-(2-naphthyl)-D-alanyl

<220>
<221>  misc-feature
<222>  (2)..(2)
<223>  Xaa is 4-chloro-D-phenylalanyl

<220>
<221>  misc-feature
<222>  (3)..(3)
<223>  Xaa is 3-(3-pyridyl)-D-alanyl

<220>
<221>  misc-feature
<222>  (6)..(6)
<223>  Xaa is D-Cit

<220>
<221>  misc-feature
<222>  (10)..(10)
<223>  Xaa is D-Ala-NH2

<400>  9

Xaa Xaa Xaa Ser Tyr Xaa Leu Arg Pro Xaa 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Synthetic


<220>
<221>  misc-feature
<222>  (1)..(1)
<223>  Xaa is N-acetyl-3-(2-naphthyl)-D-alanyl

<220>
<221>  misc-feature
<222>  (2)..(2)
<223>  Xaa is 4-chloro-D-phenylalanyl

<220>
<221>  misc-feature
<222>  (3)..(3)
<223>  Xaa is 3-(3-pyridyl)-D-alanyl

<220>
<221>  misc-feature
<222>  (5)..(5)
<223>  Xaa is N(Me)Tyr

<220>
<221>  misc-feature
<222>  (6)..(6)
<223>  Xaa is D-Asn

<220>
<221>  misc-feature
<222>  (8)..(8)
<223>  Xaa is N6-isopropyl-L-lysyl

<220>
<221>  misc-feature
<222>  (10)..(10)
<223>  Xaa is D-Ala-NH2

<400>  10

Xaa Xaa Xaa Ser Xaa Xaa Leu Xaa Pro Xaa 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Synthetic


<220>
<221>  misc-feature
<222>  (1)..(1)
<223>  Xaa is N-acetyl-3-(2-naphthyl)-D-alanyl

<220>
<221>  misc-feature
<222>  (2)..(2)
<223>  Xaa is 4-chloro-D-phenylalanyl

<220>
<221>  misc-feature
<222>  (3)..(3)
<223>  Xaa is 3-(3-pyridyl)-D-alanyl

<220>
<221>  misc-feature
<222>  (5)..(5)
<223>  Xaa is 4Aph(L-Hor)

<220>
<221>  misc-feature
<222>  (6)..(6)
<223>  Xaa is D-4Aph(Cbm)

<220>
<221>  misc-feature
<222>  (8)..(8)
<223>  Xaa is N6-isopropyl-L-lysyl

<220>
<221>  misc-feature
<222>  (10)..(10)
<223>  Xaa is D-Ala-NH2

<400>  11

Xaa Xaa Xaa Ser Xaa Xaa Leu Xaa Pro Xaa
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Synthetic


<220>
<221>  misc-feature
<222>  (1)..(1)
<223>  Xaa is N-acetyl-3-(2-naphthyl)-D-alanyl

<220>
<221>  misc-feature
<222>  (2)..(2)
<223>  Xaa is 4-chloro-D-phenylalanyl

<220>
<221>  misc-feature
<222>  (3)..(3)
<223>  Xaa is 3-(3-pyridyl)-D-alanyl

<220>
<221>  misc-feature
<222>  (6)..(6)
<223>  Xaa is D-hArg(Et2)

<220>
<221>  misc-feature
<222>  (8)..(8)
<223>  Xaa is hArg(Et2)

<220>
<221>  misc-feature
<222>  (10)..(10)
<223>  Xaa is D-Ala-NH2

<400>  12

Xaa Xaa Xaa Ser Tyr Xaa Leu Xaa Pro Xaa 
1               5                   10  


