                         SEQUENCE LISTING

<110>  Cancer Research Technology Ltd
 
<120>  Fusion Proteins

<130>  P246716WO

<140>  PCT/GB2018/053771
<141>  2018-12-24

<150>  GB 1721833.0
<151>  2017-12-22

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary ASS-1 enzyme domain

<400>  1

Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp 
1               5                   10                  15      


Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile 
            20                  25                  30          


Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg 
        35                  40                  45              


Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val 
    50                  55                  60                  


Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser 
65                  70                  75                  80  


Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala Arg Pro 
                85                  90                  95      


Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys 
            100                 105                 110         


Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe 
        115                 120                 125             


Glu Leu Ser Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile Ala Pro 
    130                 135                 140                 


Trp Arg Met Pro Glu Phe Tyr Asn Arg Phe Lys Gly Arg Asn Asp Leu 
145                 150                 155                 160 


Met Glu Tyr Ala Lys Gln His Gly Ile Pro Ile Pro Val Thr Pro Lys 
                165                 170                 175     


Asn Pro Trp Ser Met Asp Glu Asn Leu Met His Ile Ser Tyr Glu Ala 
            180                 185                 190         


Gly Ile Leu Glu Asn Pro Lys Asn Gln Ala Pro Pro Gly Leu Tyr Thr 
        195                 200                 205             


Lys Thr Gln Asp Pro Ala Lys Ala Pro Asn Thr Pro Asp Ile Leu Glu 
    210                 215                 220                 


Ile Glu Phe Lys Lys Gly Val Pro Val Lys Val Thr Asn Val Lys Asp 
225                 230                 235                 240 


Gly Thr Thr His Gln Thr Ser Leu Glu Leu Phe Met Tyr Leu Asn Glu 
                245                 250                 255     


Val Ala Gly Lys His Gly Val Gly Arg Ile Asp Ile Val Glu Asn Arg 
            260                 265                 270         


Phe Ile Gly Met Lys Ser Arg Gly Ile Tyr Glu Thr Pro Ala Gly Thr 
        275                 280                 285             


Ile Leu Tyr His Ala His Leu Asp Ile Glu Ala Phe Thr Met Asp Arg 
    290                 295                 300                 


Glu Val Arg Lys Ile Lys Gln Gly Leu Gly Leu Lys Phe Ala Glu Leu 
305                 310                 315                 320 


Val Tyr Thr Gly Phe Trp His Ser Pro Glu Cys Glu Phe Val Arg His 
                325                 330                 335     


Cys Ile Ala Lys Ser Gln Glu Arg Val Glu Gly Lys Val Gln Val Ser 
            340                 345                 350         


Val Leu Lys Gly Gln Val Tyr Ile Leu Gly Arg Glu Ser Pro Leu Ser 
        355                 360                 365             


Leu Tyr Asn Glu Glu Leu Val Ser Met Asn Val Gln Gly Asp Tyr Glu 
    370                 375                 380                 


Pro Thr Asp Ala Thr Gly Phe Ile Asn Ile Asn Ser Leu Arg Leu Lys 
385                 390                 395                 400 


Glu Tyr His Arg Leu Gln Ser Lys Val Thr Ala Lys 
                405                 410         


<210>  2
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary OTC enzyme domain

<400>  2

Met Leu Phe Asn Leu Arg Ile Leu Leu Asn Asn Ala Ala Phe Arg Asn 
1               5                   10                  15      


Gly His Asn Phe Met Val Arg Asn Phe Arg Cys Gly Gln Pro Leu Gln 
            20                  25                  30          


Asn Lys Val Gln Leu Lys Gly Arg Asp Leu Leu Thr Leu Lys Asn Phe 
        35                  40                  45              


Thr Gly Glu Glu Ile Lys Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys 
    50                  55                  60                  


Phe Arg Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys 
65                  70                  75                  80  


Ser Leu Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser 
                85                  90                  95      


Thr Glu Thr Gly Leu Ala Leu Leu Gly Gly His Pro Cys Phe Leu Thr 
            100                 105                 110         


Thr Gln Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr Asp Thr Ala 
        115                 120                 125             


Arg Val Leu Ser Ser Met Ala Asp Ala Val Leu Ala Arg Val Tyr Lys 
    130                 135                 140                 


Gln Ser Asp Leu Asp Thr Leu Ala Lys Glu Ala Ser Ile Pro Ile Ile 
145                 150                 155                 160 


Asn Gly Leu Ser Asp Leu Tyr His Pro Ile Gln Ile Leu Ala Asp Tyr 
                165                 170                 175     


Leu Thr Leu Gln Glu His Tyr Ser Ser Leu Lys Gly Leu Thr Leu Ser 
            180                 185                 190         


Trp Ile Gly Asp Gly Asn Asn Ile Leu His Ser Ile Met Met Ser Ala 
        195                 200                 205             


Ala Lys Phe Gly Met His Leu Gln Ala Ala Thr Pro Lys Gly Tyr Glu 
    210                 215                 220                 


Pro Asp Ala Ser Val Thr Lys Leu Ala Glu Gln Tyr Ala Lys Glu Asn 
225                 230                 235                 240 


Gly Thr Lys Leu Leu Leu Thr Asn Asp Pro Leu Glu Ala Ala His Gly 
                245                 250                 255     


Gly Asn Val Leu Ile Thr Asp Thr Trp Ile Ser Met Gly Gln Glu Glu 
            260                 265                 270         


Glu Lys Lys Lys Arg Leu Gln Ala Phe Gln Gly Tyr Gln Val Thr Met 
        275                 280                 285             


Lys Thr Ala Lys Val Ala Ala Ser Asp Trp Thr Phe Leu His Cys Leu 
    290                 295                 300                 


Pro Arg Lys Pro Glu Glu Val Asp Asp Glu Val Phe Tyr Ser Pro Arg 
305                 310                 315                 320 


Ser Leu Val Phe Pro Glu Ala Glu Asn Arg Lys Trp Thr Ile Met Ala 
                325                 330                 335     


Val Met Val Ser Leu Leu Thr Asp Tyr Ser Pro Gln Leu Gln Lys Pro 
            340                 345                 350         


Lys Phe 
        


<210>  3
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary GD2 target binding moiety

<400>  3

Asp Ile Leu Leu Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile His Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Glu Val Lys Leu Gln Gln Ser Gly Pro Ser 
    130                 135                 140                 


Leu Val Glu Pro Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly 
145                 150                 155                 160 


Ser Ser Phe Thr Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly 
                165                 170                 175     


Lys Ser Leu Glu Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr 
            180                 185                 190         


Ser Tyr Asn Gln Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Ser Ser Thr Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp 
    210                 215                 220                 


Ser Ala Val Tyr Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr 
                245                 250                 255     


Gly Arg Val Thr Val Ser Ser 
            260             


<210>  4
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary CD33 target binding moiety

<400>  4

Gly Ser Asn Ile Met Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser 
1               5                   10                  15      


Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe 
            20                  25                  30          


Phe Ser Ser Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro 
        35                  40                  45              


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser 
    50                  55                  60                  


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
65                  70                  75                  80  


Leu Thr Ile Ser Ser Val Gln Ser Glu Asp Leu Ala Ile Tyr Tyr Cys 
                85                  90                  95      


His Gln Tyr Leu Ser Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            100                 105                 110         


Ile Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro 
    130                 135                 140                 


Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
145                 150                 155                 160 


Ser Tyr Tyr Ile His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu 
                165                 170                 175     


Trp Val Gly Val Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln 
            180                 185                 190         


Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr 
        195                 200                 205             


Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Ala 
225                 230                 235                 240 


Gly Thr Thr Val Thr Val Ser Ser 
                245             


<210>  5
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary mesothelin target binding moiety

<400>  5

Met Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly 
1               5                   10                  15      


Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly 
            20                  25                  30          


Tyr Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp 
        35                  40                  45              


Ile Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys 
    50                  55                  60                  


Phe Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala 
65                  70                  75                  80  


Tyr Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
                85                  90                  95      


Cys Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Val Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala 
145                 150                 155                 160 


Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr 
                165                 170                 175     


Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val 
            180                 185                 190         


Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr 
        195                 200                 205             


Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln 
    210                 215                 220                 


Trp Ser Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
225                 230                 235                 240 


Lys 
    


<210>  6
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary EGFRVIII target binding moiety

<400>  6

Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Arg Lys Phe 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Gly Tyr Ser Ser Thr Ser Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala 
    130                 135                 140                 


Ser Leu Ser Val Ala Thr Gly Glu Lys Val Thr Ile Arg Cys Met Thr 
145                 150                 155                 160 


Ser Thr Asp Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Glu Pro Pro Lys Phe Leu Ile Ser Glu Gly Asn Thr Leu Arg Pro Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Ser Ser Gly Thr Gly Thr Asp Phe Val Phe 
        195                 200                 205             


Thr Ile Glu Asn Thr Leu Ser Glu Asp Val Gly Asp Tyr 
    210                 215                 220     


<210>  7
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary 4-1BB intracellular signalling region

<400>  7

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  8
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary OX-40 intracellular signalling region

<400>  8

Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly 
1               5                   10                  15      


Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr 
            20                  25                  30          


Leu Ala Lys Ile 
        35      


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary CD28 intracellular signalling region with transmembrane
       domain

<400>  9

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
            100                 105         


<210>  10
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary ICOS intracellular signalling region

<400>  10

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  11
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary CD3 zeta intracellular signalling region

<400>  11

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  12
<211>  1896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protein of the invention GD2 ASS+OTC

<400>  12

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile Leu Leu 
        355                 360                 365             


Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser 
    370                 375                 380                 


Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg Asn Gly Asn Thr 
385                 390                 395                 400 


Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                405                 410                 415     


Ile His Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
            420                 425                 430         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
        435                 440                 445             


Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro 
    450                 455                 460                 


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp 
465                 470                 475                 480 


Ala Ala Pro Thr Val Ser Ile Phe Pro Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Glu Val Lys Leu Gln Gln Ser Gly Pro Ser Leu Val Glu Pro 
            500                 505                 510         


Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr 
        515                 520                 525             


Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys Ser Leu Glu 
    530                 535                 540                 


Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln 
545                 550                 555                 560 


Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
                565                 570                 575     


Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            580                 585                 590         


Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly Thr Ser Val Thr 
        595                 600                 605             


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Gly Arg Val Thr 
    610                 615                 620                 


Val Ser Ser Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
625                 630                 635                 640 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                645                 650                 655     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            660                 665                 670         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        675                 680                 685             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    690                 695                 700                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
705                 710                 715                 720 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                725                 730                 735     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            740                 745                 750         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        755                 760                 765             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    770                 775                 780                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
785                 790                 795                 800 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                805                 810                 815     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            820                 825                 830         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        835                 840                 845             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys 
    850                 855                 860                 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
865                 870                 875                 880 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
                885                 890                 895     


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
            900                 905                 910         


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
        915                 920                 925             


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    930                 935                 940                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
945                 950                 955                 960 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                965                 970                 975     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
            980                 985                 990         


Asn Gln Leu Tyr Asn Glu Leu Asn  Leu Gly Arg Arg Glu  Glu Tyr Asp 
        995                 1000                 1005             


Val Leu  Asp Lys Arg Arg Gly  Arg Asp Pro Glu Met  Gly Gly Lys 
    1010                 1015                 1020             


Pro Arg  Arg Lys Asn Pro Gln  Glu Gly Leu Tyr Asn  Glu Leu Gln 
    1025                 1030                 1035             


Lys Asp  Lys Met Ala Glu Ala  Tyr Ser Glu Ile Gly  Met Lys Gly 
    1040                 1045                 1050             


Glu Arg  Arg Arg Gly Lys Gly  His Asp Gly Leu Tyr  Gln Gly Leu 
    1055                 1060                 1065             


Ser Thr  Ala Thr Lys Asp Thr  Tyr Asp Ala Leu His  Met Gln Ala 
    1070                 1075                 1080             


Leu Pro  Pro Arg Gly Ser Gly  Ala Thr Asn Phe Ser  Leu Leu Lys 
    1085                 1090                 1095             


Gln Ala  Gly Asp Val Glu Glu  Asn Pro Gly Pro Met  Ser Ser Lys 
    1100                 1105                 1110             


Gly Ser  Val Val Leu Ala Tyr  Ser Gly Gly Leu Asp  Thr Ser Cys 
    1115                 1120                 1125             


Ile Leu  Val Trp Leu Lys Glu  Gln Gly Tyr Asp Val  Ile Ala Tyr 
    1130                 1135                 1140             


Leu Ala  Asn Ile Gly Gln Lys  Glu Asp Phe Glu Glu  Ala Arg Lys 
    1145                 1150                 1155             


Lys Ala  Leu Lys Leu Gly Ala  Lys Lys Val Phe Ile  Glu Asp Val 
    1160                 1165                 1170             


Ser Arg  Glu Phe Val Glu Glu  Phe Ile Trp Pro Ala  Ile Gln Ser 
    1175                 1180                 1185             


Ser Ala  Leu Tyr Glu Asp Arg  Tyr Leu Leu Gly Thr  Ser Leu Ala 
    1190                 1195                 1200             


Arg Pro  Cys Ile Ala Arg Lys  Gln Val Glu Ile Ala  Gln Arg Glu 
    1205                 1210                 1215             


Gly Ala  Lys Tyr Val Ser His  Gly Ala Thr Gly Lys  Gly Asn Asp 
    1220                 1225                 1230             


Gln Val  Arg Phe Glu Leu Ser  Cys Tyr Ser Leu Ala  Pro Gln Ile 
    1235                 1240                 1245             


Lys Val  Ile Ala Pro Trp Arg  Met Pro Glu Phe Tyr  Asn Arg Phe 
    1250                 1255                 1260             


Lys Gly  Arg Asn Asp Leu Met  Glu Tyr Ala Lys Gln  His Gly Ile 
    1265                 1270                 1275             


Pro Ile  Pro Val Thr Pro Lys  Asn Pro Trp Ser Met  Asp Glu Asn 
    1280                 1285                 1290             


Leu Met  His Ile Ser Tyr Glu  Ala Gly Ile Leu Glu  Asn Pro Lys 
    1295                 1300                 1305             


Asn Gln  Ala Pro Pro Gly Leu  Tyr Thr Lys Thr Gln  Asp Pro Ala 
    1310                 1315                 1320             


Lys Ala  Pro Asn Thr Pro Asp  Ile Leu Glu Ile Glu  Phe Lys Lys 
    1325                 1330                 1335             


Gly Val  Pro Val Lys Val Thr  Asn Val Lys Asp Gly  Thr Thr His 
    1340                 1345                 1350             


Gln Thr  Ser Leu Glu Leu Phe  Met Tyr Leu Asn Glu  Val Ala Gly 
    1355                 1360                 1365             


Lys His  Gly Val Gly Arg Ile  Asp Ile Val Glu Asn  Arg Phe Ile 
    1370                 1375                 1380             


Gly Met  Lys Ser Arg Gly Ile  Tyr Glu Thr Pro Ala  Gly Thr Ile 
    1385                 1390                 1395             


Leu Tyr  His Ala His Leu Asp  Ile Glu Ala Phe Thr  Met Asp Arg 
    1400                 1405                 1410             


Glu Val  Arg Lys Ile Lys Gln  Gly Leu Gly Leu Lys  Phe Ala Glu 
    1415                 1420                 1425             


Leu Val  Tyr Thr Gly Phe Trp  His Ser Pro Glu Cys  Glu Phe Val 
    1430                 1435                 1440             


Arg His  Cys Ile Ala Lys Ser  Gln Glu Arg Val Glu  Gly Lys Val 
    1445                 1450                 1455             


Gln Val  Ser Val Leu Lys Gly  Gln Val Tyr Ile Leu  Gly Arg Glu 
    1460                 1465                 1470             


Ser Pro  Leu Ser Leu Tyr Asn  Glu Glu Leu Val Ser  Met Asn Val 
    1475                 1480                 1485             


Gln Gly  Asp Tyr Glu Pro Thr  Asp Ala Thr Gly Phe  Ile Asn Ile 
    1490                 1495                 1500             


Asn Ser  Leu Arg Leu Lys Glu  Tyr His Arg Leu Gln  Ser Lys Val 
    1505                 1510                 1515             


Thr Ala  Lys Gly Ser Gly Glu  Gly Arg Gly Ser Leu  Leu Thr Cys 
    1520                 1525                 1530             


Gly Asp  Val Glu Glu Asn Pro  Gly Pro Met Leu Phe  Asn Leu Arg 
    1535                 1540                 1545             


Ile Leu  Leu Asn Asn Ala Ala  Phe Arg Asn Gly His  Asn Phe Met 
    1550                 1555                 1560             


Val Arg  Asn Phe Arg Cys Gly  Gln Pro Leu Gln Asn  Lys Val Gln 
    1565                 1570                 1575             


Leu Lys  Gly Arg Asp Leu Leu  Thr Leu Lys Asn Phe  Thr Gly Glu 
    1580                 1585                 1590             


Glu Ile  Lys Tyr Met Leu Trp  Leu Ser Ala Asp Leu  Lys Phe Arg 
    1595                 1600                 1605             


Ile Lys  Gln Lys Gly Glu Tyr  Leu Pro Leu Leu Gln  Gly Lys Ser 
    1610                 1615                 1620             


Leu Gly  Met Ile Phe Glu Lys  Arg Ser Thr Arg Thr  Arg Leu Ser 
    1625                 1630                 1635             


Thr Glu  Thr Gly Leu Ala Leu  Leu Gly Gly His Pro  Cys Phe Leu 
    1640                 1645                 1650             


Thr Thr  Gln Asp Ile His Leu  Gly Val Asn Glu Ser  Leu Thr Asp 
    1655                 1660                 1665             


Thr Ala  Arg Val Leu Ser Ser  Met Ala Asp Ala Val  Leu Ala Arg 
    1670                 1675                 1680             


Val Tyr  Lys Gln Ser Asp Leu  Asp Thr Leu Ala Lys  Glu Ala Ser 
    1685                 1690                 1695             


Ile Pro  Ile Ile Asn Gly Leu  Ser Asp Leu Tyr His  Pro Ile Gln 
    1700                 1705                 1710             


Ile Leu  Ala Asp Tyr Leu Thr  Leu Gln Glu His Tyr  Ser Ser Leu 
    1715                 1720                 1725             


Lys Gly  Leu Thr Leu Ser Trp  Ile Gly Asp Gly Asn  Asn Ile Leu 
    1730                 1735                 1740             


His Ser  Ile Met Met Ser Ala  Ala Lys Phe Gly Met  His Leu Gln 
    1745                 1750                 1755             


Ala Ala  Thr Pro Lys Gly Tyr  Glu Pro Asp Ala Ser  Val Thr Lys 
    1760                 1765                 1770             


Leu Ala  Glu Gln Tyr Ala Lys  Glu Asn Gly Thr Lys  Leu Leu Leu 
    1775                 1780                 1785             


Thr Asn  Asp Pro Leu Glu Ala  Ala His Gly Gly Asn  Val Leu Ile 
    1790                 1795                 1800             


Thr Asp  Thr Trp Ile Ser Met  Gly Gln Glu Glu Glu  Lys Lys Lys 
    1805                 1810                 1815             


Arg Leu  Gln Ala Phe Gln Gly  Tyr Gln Val Thr Met  Lys Thr Ala 
    1820                 1825                 1830             


Lys Val  Ala Ala Ser Asp Trp  Thr Phe Leu His Cys  Leu Pro Arg 
    1835                 1840                 1845             


Lys Pro  Glu Glu Val Asp Asp  Glu Val Phe Tyr Ser  Pro Arg Ser 
    1850                 1855                 1860             


Leu Val  Phe Pro Glu Ala Glu  Asn Arg Lys Trp Thr  Ile Met Ala 
    1865                 1870                 1875             


Val Met  Val Ser Leu Leu Thr  Asp Tyr Ser Pro Gln  Leu Gln Lys 
    1880                 1885                 1890             


Pro Lys  Phe 
    1895     


<210>  13
<211>  1521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protein of the invention GD2 ASS1

<400>  13

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile Leu Leu 
        355                 360                 365             


Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser 
    370                 375                 380                 


Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg Asn Gly Asn Thr 
385                 390                 395                 400 


Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                405                 410                 415     


Ile His Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
            420                 425                 430         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
        435                 440                 445             


Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro 
    450                 455                 460                 


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp 
465                 470                 475                 480 


Ala Ala Pro Thr Val Ser Ile Phe Pro Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Glu Val Lys Leu Gln Gln Ser Gly Pro Ser Leu Val Glu Pro 
            500                 505                 510         


Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr 
        515                 520                 525             


Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys Ser Leu Glu 
    530                 535                 540                 


Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln 
545                 550                 555                 560 


Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
                565                 570                 575     


Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            580                 585                 590         


Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly Thr Ser Val Thr 
        595                 600                 605             


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Gly Arg Val Thr 
    610                 615                 620                 


Val Ser Ser Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
625                 630                 635                 640 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                645                 650                 655     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            660                 665                 670         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        675                 680                 685             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    690                 695                 700                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
705                 710                 715                 720 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                725                 730                 735     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            740                 745                 750         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        755                 760                 765             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    770                 775                 780                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
785                 790                 795                 800 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                805                 810                 815     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            820                 825                 830         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        835                 840                 845             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys 
    850                 855                 860                 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
865                 870                 875                 880 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
                885                 890                 895     


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
            900                 905                 910         


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
        915                 920                 925             


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    930                 935                 940                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
945                 950                 955                 960 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                965                 970                 975     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
            980                 985                 990         


Asn Gln Leu Tyr Asn Glu Leu Asn  Leu Gly Arg Arg Glu  Glu Tyr Asp 
        995                 1000                 1005             


Val Leu  Asp Lys Arg Arg Gly  Arg Asp Pro Glu Met  Gly Gly Lys 
    1010                 1015                 1020             


Pro Arg  Arg Lys Asn Pro Gln  Glu Gly Leu Tyr Asn  Glu Leu Gln 
    1025                 1030                 1035             


Lys Asp  Lys Met Ala Glu Ala  Tyr Ser Glu Ile Gly  Met Lys Gly 
    1040                 1045                 1050             


Glu Arg  Arg Arg Gly Lys Gly  His Asp Gly Leu Tyr  Gln Gly Leu 
    1055                 1060                 1065             


Ser Thr  Ala Thr Lys Asp Thr  Tyr Asp Ala Leu His  Met Gln Ala 
    1070                 1075                 1080             


Leu Pro  Pro Arg Gly Ser Gly  Ala Thr Asn Phe Ser  Leu Leu Lys 
    1085                 1090                 1095             


Gln Ala  Gly Asp Val Glu Glu  Asn Pro Gly Pro Met  Ser Ser Lys 
    1100                 1105                 1110             


Gly Ser  Val Val Leu Ala Tyr  Ser Gly Gly Leu Asp  Thr Ser Cys 
    1115                 1120                 1125             


Ile Leu  Val Trp Leu Lys Glu  Gln Gly Tyr Asp Val  Ile Ala Tyr 
    1130                 1135                 1140             


Leu Ala  Asn Ile Gly Gln Lys  Glu Asp Phe Glu Glu  Ala Arg Lys 
    1145                 1150                 1155             


Lys Ala  Leu Lys Leu Gly Ala  Lys Lys Val Phe Ile  Glu Asp Val 
    1160                 1165                 1170             


Ser Arg  Glu Phe Val Glu Glu  Phe Ile Trp Pro Ala  Ile Gln Ser 
    1175                 1180                 1185             


Ser Ala  Leu Tyr Glu Asp Arg  Tyr Leu Leu Gly Thr  Ser Leu Ala 
    1190                 1195                 1200             


Arg Pro  Cys Ile Ala Arg Lys  Gln Val Glu Ile Ala  Gln Arg Glu 
    1205                 1210                 1215             


Gly Ala  Lys Tyr Val Ser His  Gly Ala Thr Gly Lys  Gly Asn Asp 
    1220                 1225                 1230             


Gln Val  Arg Phe Glu Leu Ser  Cys Tyr Ser Leu Ala  Pro Gln Ile 
    1235                 1240                 1245             


Lys Val  Ile Ala Pro Trp Arg  Met Pro Glu Phe Tyr  Asn Arg Phe 
    1250                 1255                 1260             


Lys Gly  Arg Asn Asp Leu Met  Glu Tyr Ala Lys Gln  His Gly Ile 
    1265                 1270                 1275             


Pro Ile  Pro Val Thr Pro Lys  Asn Pro Trp Ser Met  Asp Glu Asn 
    1280                 1285                 1290             


Leu Met  His Ile Ser Tyr Glu  Ala Gly Ile Leu Glu  Asn Pro Lys 
    1295                 1300                 1305             


Asn Gln  Ala Pro Pro Gly Leu  Tyr Thr Lys Thr Gln  Asp Pro Ala 
    1310                 1315                 1320             


Lys Ala  Pro Asn Thr Pro Asp  Ile Leu Glu Ile Glu  Phe Lys Lys 
    1325                 1330                 1335             


Gly Val  Pro Val Lys Val Thr  Asn Val Lys Asp Gly  Thr Thr His 
    1340                 1345                 1350             


Gln Thr  Ser Leu Glu Leu Phe  Met Tyr Leu Asn Glu  Val Ala Gly 
    1355                 1360                 1365             


Lys His  Gly Val Gly Arg Ile  Asp Ile Val Glu Asn  Arg Phe Ile 
    1370                 1375                 1380             


Gly Met  Lys Ser Arg Gly Ile  Tyr Glu Thr Pro Ala  Gly Thr Ile 
    1385                 1390                 1395             


Leu Tyr  His Ala His Leu Asp  Ile Glu Ala Phe Thr  Met Asp Arg 
    1400                 1405                 1410             


Glu Val  Arg Lys Ile Lys Gln  Gly Leu Gly Leu Lys  Phe Ala Glu 
    1415                 1420                 1425             


Leu Val  Tyr Thr Gly Phe Trp  His Ser Pro Glu Cys  Glu Phe Val 
    1430                 1435                 1440             


Arg His  Cys Ile Ala Lys Ser  Gln Glu Arg Val Glu  Gly Lys Val 
    1445                 1450                 1455             


Gln Val  Ser Val Leu Lys Gly  Gln Val Tyr Ile Leu  Gly Arg Glu 
    1460                 1465                 1470             


Ser Pro  Leu Ser Leu Tyr Asn  Glu Glu Leu Val Ser  Met Asn Val 
    1475                 1480                 1485             


Gln Gly  Asp Tyr Glu Pro Thr  Asp Ala Thr Gly Phe  Ile Asn Ile 
    1490                 1495                 1500             


Asn Ser  Leu Arg Leu Lys Glu  Tyr His Arg Leu Gln  Ser Lys Val 
    1505                 1510                 1515             


Thr Ala  Lys 
    1520     


<210>  14
<211>  1463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protein of the invention GD2 OTC

<400>  14

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Asp Ile Leu Leu 
        355                 360                 365             


Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser 
    370                 375                 380                 


Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg Asn Gly Asn Thr 
385                 390                 395                 400 


Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
                405                 410                 415     


Ile His Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser 
            420                 425                 430         


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu 
        435                 440                 445             


Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro 
    450                 455                 460                 


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp 
465                 470                 475                 480 


Ala Ala Pro Thr Val Ser Ile Phe Pro Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Glu Val Lys Leu Gln Gln Ser Gly Pro Ser Leu Val Glu Pro 
            500                 505                 510         


Gly Ala Ser Val Met Ile Ser Cys Lys Ala Ser Gly Ser Ser Phe Thr 
        515                 520                 525             


Gly Tyr Asn Met Asn Trp Val Arg Gln Asn Ile Gly Lys Ser Leu Glu 
    530                 535                 540                 


Trp Ile Gly Ala Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln 
545                 550                 555                 560 


Lys Phe Lys Gly Arg Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
                565                 570                 575     


Ala Tyr Met His Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr 
            580                 585                 590         


Tyr Cys Val Ser Gly Met Glu Tyr Trp Gly Gln Gly Thr Ser Val Thr 
        595                 600                 605             


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Gly Arg Val Thr 
    610                 615                 620                 


Val Ser Ser Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
625                 630                 635                 640 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                645                 650                 655     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            660                 665                 670         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        675                 680                 685             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    690                 695                 700                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
705                 710                 715                 720 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                725                 730                 735     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            740                 745                 750         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        755                 760                 765             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    770                 775                 780                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
785                 790                 795                 800 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                805                 810                 815     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            820                 825                 830         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        835                 840                 845             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Lys Asp Pro Lys 
    850                 855                 860                 


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
865                 870                 875                 880 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
                885                 890                 895     


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
            900                 905                 910         


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
        915                 920                 925             


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    930                 935                 940                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
945                 950                 955                 960 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
                965                 970                 975     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln 
            980                 985                 990         


Asn Gln Leu Tyr Asn Glu Leu Asn  Leu Gly Arg Arg Glu  Glu Tyr Asp 
        995                 1000                 1005             


Val Leu  Asp Lys Arg Arg Gly  Arg Asp Pro Glu Met  Gly Gly Lys 
    1010                 1015                 1020             


Pro Arg  Arg Lys Asn Pro Gln  Glu Gly Leu Tyr Asn  Glu Leu Gln 
    1025                 1030                 1035             


Lys Asp  Lys Met Ala Glu Ala  Tyr Ser Glu Ile Gly  Met Lys Gly 
    1040                 1045                 1050             


Glu Arg  Arg Arg Gly Lys Gly  His Asp Gly Leu Tyr  Gln Gly Leu 
    1055                 1060                 1065             


Ser Thr  Ala Thr Lys Asp Thr  Tyr Asp Ala Leu His  Met Gln Ala 
    1070                 1075                 1080             


Leu Pro  Pro Arg Gly Ser Gly  Ala Thr Asn Phe Ser  Leu Leu Lys 
    1085                 1090                 1095             


Gln Ala  Gly Asp Val Glu Glu  Asn Pro Gly Pro Met  Leu Phe Asn 
    1100                 1105                 1110             


Leu Arg  Ile Leu Leu Asn Asn  Ala Ala Phe Arg Asn  Gly His Asn 
    1115                 1120                 1125             


Phe Met  Val Arg Asn Phe Arg  Cys Gly Gln Pro Leu  Gln Asn Lys 
    1130                 1135                 1140             


Val Gln  Leu Lys Gly Arg Asp  Leu Leu Thr Leu Lys  Asn Phe Thr 
    1145                 1150                 1155             


Gly Glu  Glu Ile Lys Tyr Met  Leu Trp Leu Ser Ala  Asp Leu Lys 
    1160                 1165                 1170             


Phe Arg  Ile Lys Gln Lys Gly  Glu Tyr Leu Pro Leu  Leu Gln Gly 
    1175                 1180                 1185             


Lys Ser  Leu Gly Met Ile Phe  Glu Lys Arg Ser Thr  Arg Thr Arg 
    1190                 1195                 1200             


Leu Ser  Thr Glu Thr Gly Leu  Ala Leu Leu Gly Gly  His Pro Cys 
    1205                 1210                 1215             


Phe Leu  Thr Thr Gln Asp Ile  His Leu Gly Val Asn  Glu Ser Leu 
    1220                 1225                 1230             


Thr Asp  Thr Ala Arg Val Leu  Ser Ser Met Ala Asp  Ala Val Leu 
    1235                 1240                 1245             


Ala Arg  Val Tyr Lys Gln Ser  Asp Leu Asp Thr Leu  Ala Lys Glu 
    1250                 1255                 1260             


Ala Ser  Ile Pro Ile Ile Asn  Gly Leu Ser Asp Leu  Tyr His Pro 
    1265                 1270                 1275             


Ile Gln  Ile Leu Ala Asp Tyr  Leu Thr Leu Gln Glu  His Tyr Ser 
    1280                 1285                 1290             


Ser Leu  Lys Gly Leu Thr Leu  Ser Trp Ile Gly Asp  Gly Asn Asn 
    1295                 1300                 1305             


Ile Leu  His Ser Ile Met Met  Ser Ala Ala Lys Phe  Gly Met His 
    1310                 1315                 1320             


Leu Gln  Ala Ala Thr Pro Lys  Gly Tyr Glu Pro Asp  Ala Ser Val 
    1325                 1330                 1335             


Thr Lys  Leu Ala Glu Gln Tyr  Ala Lys Glu Asn Gly  Thr Lys Leu 
    1340                 1345                 1350             


Leu Leu  Thr Asn Asp Pro Leu  Glu Ala Ala His Gly  Gly Asn Val 
    1355                 1360                 1365             


Leu Ile  Thr Asp Thr Trp Ile  Ser Met Gly Gln Glu  Glu Glu Lys 
    1370                 1375                 1380             


Lys Lys  Arg Leu Gln Ala Phe  Gln Gly Tyr Gln Val  Thr Met Lys 
    1385                 1390                 1395             


Thr Ala  Lys Val Ala Ala Ser  Asp Trp Thr Phe Leu  His Cys Leu 
    1400                 1405                 1410             


Pro Arg  Lys Pro Glu Glu Val  Asp Asp Glu Val Phe  Tyr Ser Pro 
    1415                 1420                 1425             


Arg Ser  Leu Val Phe Pro Glu  Ala Glu Asn Arg Lys  Trp Thr Ile 
    1430                 1435                 1440             


Met Ala  Val Met Val Ser Leu  Leu Thr Asp Tyr Ser  Pro Gln Leu 
    1445                 1450                 1455             


Gln Lys  Pro Lys Phe 
    1460             


<210>  15
<211>  1637
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protein of the invention Mesothelin ASS1+OTC

<400>  15

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Met Gln Val Gln 
        355                 360                 365             


Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys 
    370                 375                 380                 


Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn 
385                 390                 395                 400 


Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Leu Ile 
                405                 410                 415     


Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys 
            420                 425                 430         


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu 
        435                 440                 445             


Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly 
    450                 455                 460                 


Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
465                 470                 475                 480 


Thr Val Ser Ser Gly Val Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            500                 505                 510         


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
        515                 520                 525             


Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
    530                 535                 540                 


Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe 
545                 550                 555                 560 


Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val 
                565                 570                 575     


Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr 
            580                 585                 590         


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr 
        595                 600                 605             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    610                 615                 620                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
625                 630                 635                 640 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                645                 650                 655     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            660                 665                 670         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        675                 680                 685             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    690                 695                 700                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
705                 710                 715                 720 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                725                 730                 735     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            740                 745                 750         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        755                 760                 765             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    770                 775                 780                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
785                 790                 795                 800 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                805                 810                 815     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala 
            820                 825                 830         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        835                 840                 845             


Gly Pro Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly 
    850                 855                 860                 


Leu Asp Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp 
865                 870                 875                 880 


Val Ile Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu 
                885                 890                 895     


Ala Arg Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu 
            900                 905                 910         


Asp Val Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln 
        915                 920                 925             


Ser Ser Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala 
    930                 935                 940                 


Arg Pro Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly 
945                 950                 955                 960 


Ala Lys Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val 
                965                 970                 975     


Arg Phe Glu Leu Ser Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile 
            980                 985                 990         


Ala Pro Trp Arg Met Pro Glu Phe  Tyr Asn Arg Phe Lys  Gly Arg Asn 
        995                 1000                 1005             


Asp Leu  Met Glu Tyr Ala Lys  Gln His Gly Ile Pro  Ile Pro Val 
    1010                 1015                 1020             


Thr Pro  Lys Asn Pro Trp Ser  Met Asp Glu Asn Leu  Met His Ile 
    1025                 1030                 1035             


Ser Tyr  Glu Ala Gly Ile Leu  Glu Asn Pro Lys Asn  Gln Ala Pro 
    1040                 1045                 1050             


Pro Gly  Leu Tyr Thr Lys Thr  Gln Asp Pro Ala Lys  Ala Pro Asn 
    1055                 1060                 1065             


Thr Pro  Asp Ile Leu Glu Ile  Glu Phe Lys Lys Gly  Val Pro Val 
    1070                 1075                 1080             


Lys Val  Thr Asn Val Lys Asp  Gly Thr Thr His Gln  Thr Ser Leu 
    1085                 1090                 1095             


Glu Leu  Phe Met Tyr Leu Asn  Glu Val Ala Gly Lys  His Gly Val 
    1100                 1105                 1110             


Gly Arg  Ile Asp Ile Val Glu  Asn Arg Phe Ile Gly  Met Lys Ser 
    1115                 1120                 1125             


Arg Gly  Ile Tyr Glu Thr Pro  Ala Gly Thr Ile Leu  Tyr His Ala 
    1130                 1135                 1140             


His Leu  Asp Ile Glu Ala Phe  Thr Met Asp Arg Glu  Val Arg Lys 
    1145                 1150                 1155             


Ile Lys  Gln Gly Leu Gly Leu  Lys Phe Ala Glu Leu  Val Tyr Thr 
    1160                 1165                 1170             


Gly Phe  Trp His Ser Pro Glu  Cys Glu Phe Val Arg  His Cys Ile 
    1175                 1180                 1185             


Ala Lys  Ser Gln Glu Arg Val  Glu Gly Lys Val Gln  Val Ser Val 
    1190                 1195                 1200             


Leu Lys  Gly Gln Val Tyr Ile  Leu Gly Arg Glu Ser  Pro Leu Ser 
    1205                 1210                 1215             


Leu Tyr  Asn Glu Glu Leu Val  Ser Met Asn Val Gln  Gly Asp Tyr 
    1220                 1225                 1230             


Glu Pro  Thr Asp Ala Thr Gly  Phe Ile Asn Ile Asn  Ser Leu Arg 
    1235                 1240                 1245             


Leu Lys  Glu Tyr His Arg Leu  Gln Ser Lys Val Thr  Ala Lys Gly 
    1250                 1255                 1260             


Ser Gly  Glu Gly Arg Gly Ser  Leu Leu Thr Cys Gly  Asp Val Glu 
    1265                 1270                 1275             


Glu Asn  Pro Gly Pro Met Leu  Phe Asn Leu Arg Ile  Leu Leu Asn 
    1280                 1285                 1290             


Asn Ala  Ala Phe Arg Asn Gly  His Asn Phe Met Val  Arg Asn Phe 
    1295                 1300                 1305             


Arg Cys  Gly Gln Pro Leu Gln  Asn Lys Val Gln Leu  Lys Gly Arg 
    1310                 1315                 1320             


Asp Leu  Leu Thr Leu Lys Asn  Phe Thr Gly Glu Glu  Ile Lys Tyr 
    1325                 1330                 1335             


Met Leu  Trp Leu Ser Ala Asp  Leu Lys Phe Arg Ile  Lys Gln Lys 
    1340                 1345                 1350             


Gly Glu  Tyr Leu Pro Leu Leu  Gln Gly Lys Ser Leu  Gly Met Ile 
    1355                 1360                 1365             


Phe Glu  Lys Arg Ser Thr Arg  Thr Arg Leu Ser Thr  Glu Thr Gly 
    1370                 1375                 1380             


Leu Ala  Leu Leu Gly Gly His  Pro Cys Phe Leu Thr  Thr Gln Asp 
    1385                 1390                 1395             


Ile His  Leu Gly Val Asn Glu  Ser Leu Thr Asp Thr  Ala Arg Val 
    1400                 1405                 1410             


Leu Ser  Ser Met Ala Asp Ala  Val Leu Ala Arg Val  Tyr Lys Gln 
    1415                 1420                 1425             


Ser Asp  Leu Asp Thr Leu Ala  Lys Glu Ala Ser Ile  Pro Ile Ile 
    1430                 1435                 1440             


Asn Gly  Leu Ser Asp Leu Tyr  His Pro Ile Gln Ile  Leu Ala Asp 
    1445                 1450                 1455             


Tyr Leu  Thr Leu Gln Glu His  Tyr Ser Ser Leu Lys  Gly Leu Thr 
    1460                 1465                 1470             


Leu Ser  Trp Ile Gly Asp Gly  Asn Asn Ile Leu His  Ser Ile Met 
    1475                 1480                 1485             


Met Ser  Ala Ala Lys Phe Gly  Met His Leu Gln Ala  Ala Thr Pro 
    1490                 1495                 1500             


Lys Gly  Tyr Glu Pro Asp Ala  Ser Val Thr Lys Leu  Ala Glu Gln 
    1505                 1510                 1515             


Tyr Ala  Lys Glu Asn Gly Thr  Lys Leu Leu Leu Thr  Asn Asp Pro 
    1520                 1525                 1530             


Leu Glu  Ala Ala His Gly Gly  Asn Val Leu Ile Thr  Asp Thr Trp 
    1535                 1540                 1545             


Ile Ser  Met Gly Gln Glu Glu  Glu Lys Lys Lys Arg  Leu Gln Ala 
    1550                 1555                 1560             


Phe Gln  Gly Tyr Gln Val Thr  Met Lys Thr Ala Lys  Val Ala Ala 
    1565                 1570                 1575             


Ser Asp  Trp Thr Phe Leu His  Cys Leu Pro Arg Lys  Pro Glu Glu 
    1580                 1585                 1590             


Val Asp  Asp Glu Val Phe Tyr  Ser Pro Arg Ser Leu  Val Phe Pro 
    1595                 1600                 1605             


Glu Ala  Glu Asn Arg Lys Trp  Thr Ile Met Ala Val  Met Val Ser 
    1610                 1615                 1620             


Leu Leu  Thr Asp Tyr Ser Pro  Gln Leu Gln Lys Pro  Lys Phe 
    1625                 1630                 1635         


<210>  16
<211>  1262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protein of the invention Mesothelin ASS

<400>  16

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Met Gln Val Gln 
        355                 360                 365             


Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys 
    370                 375                 380                 


Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn 
385                 390                 395                 400 


Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Leu Ile 
                405                 410                 415     


Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys 
            420                 425                 430         


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu 
        435                 440                 445             


Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly 
    450                 455                 460                 


Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
465                 470                 475                 480 


Thr Val Ser Ser Gly Val Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            500                 505                 510         


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
        515                 520                 525             


Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
    530                 535                 540                 


Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe 
545                 550                 555                 560 


Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val 
                565                 570                 575     


Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr 
            580                 585                 590         


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr 
        595                 600                 605             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    610                 615                 620                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
625                 630                 635                 640 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                645                 650                 655     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            660                 665                 670         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        675                 680                 685             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    690                 695                 700                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
705                 710                 715                 720 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                725                 730                 735     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            740                 745                 750         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        755                 760                 765             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    770                 775                 780                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
785                 790                 795                 800 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                805                 810                 815     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala 
            820                 825                 830         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        835                 840                 845             


Gly Pro Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly 
    850                 855                 860                 


Leu Asp Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp 
865                 870                 875                 880 


Val Ile Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu 
                885                 890                 895     


Ala Arg Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu 
            900                 905                 910         


Asp Val Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln 
        915                 920                 925             


Ser Ser Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala 
    930                 935                 940                 


Arg Pro Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly 
945                 950                 955                 960 


Ala Lys Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val 
                965                 970                 975     


Arg Phe Glu Leu Ser Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile 
            980                 985                 990         


Ala Pro Trp Arg Met Pro Glu Phe  Tyr Asn Arg Phe Lys  Gly Arg Asn 
        995                 1000                 1005             


Asp Leu  Met Glu Tyr Ala Lys  Gln His Gly Ile Pro  Ile Pro Val 
    1010                 1015                 1020             


Thr Pro  Lys Asn Pro Trp Ser  Met Asp Glu Asn Leu  Met His Ile 
    1025                 1030                 1035             


Ser Tyr  Glu Ala Gly Ile Leu  Glu Asn Pro Lys Asn  Gln Ala Pro 
    1040                 1045                 1050             


Pro Gly  Leu Tyr Thr Lys Thr  Gln Asp Pro Ala Lys  Ala Pro Asn 
    1055                 1060                 1065             


Thr Pro  Asp Ile Leu Glu Ile  Glu Phe Lys Lys Gly  Val Pro Val 
    1070                 1075                 1080             


Lys Val  Thr Asn Val Lys Asp  Gly Thr Thr His Gln  Thr Ser Leu 
    1085                 1090                 1095             


Glu Leu  Phe Met Tyr Leu Asn  Glu Val Ala Gly Lys  His Gly Val 
    1100                 1105                 1110             


Gly Arg  Ile Asp Ile Val Glu  Asn Arg Phe Ile Gly  Met Lys Ser 
    1115                 1120                 1125             


Arg Gly  Ile Tyr Glu Thr Pro  Ala Gly Thr Ile Leu  Tyr His Ala 
    1130                 1135                 1140             


His Leu  Asp Ile Glu Ala Phe  Thr Met Asp Arg Glu  Val Arg Lys 
    1145                 1150                 1155             


Ile Lys  Gln Gly Leu Gly Leu  Lys Phe Ala Glu Leu  Val Tyr Thr 
    1160                 1165                 1170             


Gly Phe  Trp His Ser Pro Glu  Cys Glu Phe Val Arg  His Cys Ile 
    1175                 1180                 1185             


Ala Lys  Ser Gln Glu Arg Val  Glu Gly Lys Val Gln  Val Ser Val 
    1190                 1195                 1200             


Leu Lys  Gly Gln Val Tyr Ile  Leu Gly Arg Glu Ser  Pro Leu Ser 
    1205                 1210                 1215             


Leu Tyr  Asn Glu Glu Leu Val  Ser Met Asn Val Gln  Gly Asp Tyr 
    1220                 1225                 1230             


Glu Pro  Thr Asp Ala Thr Gly  Phe Ile Asn Ile Asn  Ser Leu Arg 
    1235                 1240                 1245             


Leu Lys  Glu Tyr His Arg Leu  Gln Ser Lys Val Thr  Ala Lys 
    1250                 1255                 1260         


<210>  17
<211>  1204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protein of the invention Mesothelin OTC

<400>  17

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Met Gln Val Gln 
        355                 360                 365             


Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala Ser Val Lys 
    370                 375                 380                 


Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr Thr Met Asn 
385                 390                 395                 400 


Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Leu Ile 
                405                 410                 415     


Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe Arg Gly Lys 
            420                 425                 430         


Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Asp Leu 
        435                 440                 445             


Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly 
    450                 455                 460                 


Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val 
465                 470                 475                 480 


Thr Val Ser Ser Gly Val Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ile Met Ser Ala 
            500                 505                 510         


Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val 
        515                 520                 525             


Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg 
    530                 535                 540                 


Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe 
545                 550                 555                 560 


Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Val 
                565                 570                 575     


Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr 
            580                 585                 590         


Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr 
        595                 600                 605             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    610                 615                 620                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
625                 630                 635                 640 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                645                 650                 655     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            660                 665                 670         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        675                 680                 685             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    690                 695                 700                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
705                 710                 715                 720 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu 
                725                 730                 735     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            740                 745                 750         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        755                 760                 765             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    770                 775                 780                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
785                 790                 795                 800 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                805                 810                 815     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala 
            820                 825                 830         


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
        835                 840                 845             


Gly Pro Met Leu Phe Asn Leu Arg Ile Leu Leu Asn Asn Ala Ala Phe 
    850                 855                 860                 


Arg Asn Gly His Asn Phe Met Val Arg Asn Phe Arg Cys Gly Gln Pro 
865                 870                 875                 880 


Leu Gln Asn Lys Val Gln Leu Lys Gly Arg Asp Leu Leu Thr Leu Lys 
                885                 890                 895     


Asn Phe Thr Gly Glu Glu Ile Lys Tyr Met Leu Trp Leu Ser Ala Asp 
            900                 905                 910         


Leu Lys Phe Arg Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln 
        915                 920                 925             


Gly Lys Ser Leu Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg 
    930                 935                 940                 


Leu Ser Thr Glu Thr Gly Leu Ala Leu Leu Gly Gly His Pro Cys Phe 
945                 950                 955                 960 


Leu Thr Thr Gln Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr Asp 
                965                 970                 975     


Thr Ala Arg Val Leu Ser Ser Met Ala Asp Ala Val Leu Ala Arg Val 
            980                 985                 990         


Tyr Lys Gln Ser Asp Leu Asp Thr  Leu Ala Lys Glu Ala  Ser Ile Pro 
        995                 1000                 1005             


Ile Ile  Asn Gly Leu Ser Asp  Leu Tyr His Pro Ile  Gln Ile Leu 
    1010                 1015                 1020             


Ala Asp  Tyr Leu Thr Leu Gln  Glu His Tyr Ser Ser  Leu Lys Gly 
    1025                 1030                 1035             


Leu Thr  Leu Ser Trp Ile Gly  Asp Gly Asn Asn Ile  Leu His Ser 
    1040                 1045                 1050             


Ile Met  Met Ser Ala Ala Lys  Phe Gly Met His Leu  Gln Ala Ala 
    1055                 1060                 1065             


Thr Pro  Lys Gly Tyr Glu Pro  Asp Ala Ser Val Thr  Lys Leu Ala 
    1070                 1075                 1080             


Glu Gln  Tyr Ala Lys Glu Asn  Gly Thr Lys Leu Leu  Leu Thr Asn 
    1085                 1090                 1095             


Asp Pro  Leu Glu Ala Ala His  Gly Gly Asn Val Leu  Ile Thr Asp 
    1100                 1105                 1110             


Thr Trp  Ile Ser Met Gly Gln  Glu Glu Glu Lys Lys  Lys Arg Leu 
    1115                 1120                 1125             


Gln Ala  Phe Gln Gly Tyr Gln  Val Thr Met Lys Thr  Ala Lys Val 
    1130                 1135                 1140             


Ala Ala  Ser Asp Trp Thr Phe  Leu His Cys Leu Pro  Arg Lys Pro 
    1145                 1150                 1155             


Glu Glu  Val Asp Asp Glu Val  Phe Tyr Ser Pro Arg  Ser Leu Val 
    1160                 1165                 1170             


Phe Pro  Glu Ala Glu Asn Arg  Lys Trp Thr Ile Met  Ala Val Met 
    1175                 1180                 1185             


Val Ser  Leu Leu Thr Asp Tyr  Ser Pro Gln Leu Gln  Lys Pro Lys 
    1190                 1195                 1200             


Phe 
    


<210>  18
<211>  1644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protein of the invention CD33 ASS+OTC

<400>  18

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Ser Asn Ile 
        355                 360                 365             


Met Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly Glu Lys 
    370                 375                 380                 


Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe Ser Ser Ser 
385                 390                 395                 400 


Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ser Pro 
                405                 410                 415     


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
            420                 425                 430         


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        435                 440                 445             


Ser Val Gln Ser Glu Asp Leu Ala Ile Tyr Tyr Cys His Gln Tyr Leu 
    450                 455                 460                 


Ser Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Val 
                485                 490                 495     


Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val 
            500                 505                 510         


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile 
        515                 520                 525             


His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Val Gly Val 
    530                 535                 540                 


Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe Lys Gly 
545                 550                 555                 560 


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr Met Gln 
                565                 570                 575     


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            580                 585                 590         


Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
        595                 600                 605             


Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    610                 615                 620                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
625                 630                 635                 640 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                645                 650                 655     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            660                 665                 670         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
        675                 680                 685             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    690                 695                 700                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
705                 710                 715                 720 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                725                 730                 735     


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            740                 745                 750         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        755                 760                 765             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    770                 775                 780                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
785                 790                 795                 800 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                805                 810                 815     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            820                 825                 830         


Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        835                 840                 845             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Ser Lys Gly Ser Val 
    850                 855                 860                 


Val Leu Ala Tyr Ser Gly Gly Leu Asp Thr Ser Cys Ile Leu Val Trp 
865                 870                 875                 880 


Leu Lys Glu Gln Gly Tyr Asp Val Ile Ala Tyr Leu Ala Asn Ile Gly 
                885                 890                 895     


Gln Lys Glu Asp Phe Glu Glu Ala Arg Lys Lys Ala Leu Lys Leu Gly 
            900                 905                 910         


Ala Lys Lys Val Phe Ile Glu Asp Val Ser Arg Glu Phe Val Glu Glu 
        915                 920                 925             


Phe Ile Trp Pro Ala Ile Gln Ser Ser Ala Leu Tyr Glu Asp Arg Tyr 
    930                 935                 940                 


Leu Leu Gly Thr Ser Leu Ala Arg Pro Cys Ile Ala Arg Lys Gln Val 
945                 950                 955                 960 


Glu Ile Ala Gln Arg Glu Gly Ala Lys Tyr Val Ser His Gly Ala Thr 
                965                 970                 975     


Gly Lys Gly Asn Asp Gln Val Arg Phe Glu Leu Ser Cys Tyr Ser Leu 
            980                 985                 990         


Ala Pro Gln Ile Lys Val Ile Ala  Pro Trp Arg Met Pro  Glu Phe Tyr 
        995                 1000                 1005             


Asn Arg  Phe Lys Gly Arg Asn  Asp Leu Met Glu Tyr  Ala Lys Gln 
    1010                 1015                 1020             


His Gly  Ile Pro Ile Pro Val  Thr Pro Lys Asn Pro  Trp Ser Met 
    1025                 1030                 1035             


Asp Glu  Asn Leu Met His Ile  Ser Tyr Glu Ala Gly  Ile Leu Glu 
    1040                 1045                 1050             


Asn Pro  Lys Asn Gln Ala Pro  Pro Gly Leu Tyr Thr  Lys Thr Gln 
    1055                 1060                 1065             


Asp Pro  Ala Lys Ala Pro Asn  Thr Pro Asp Ile Leu  Glu Ile Glu 
    1070                 1075                 1080             


Phe Lys  Lys Gly Val Pro Val  Lys Val Thr Asn Val  Lys Asp Gly 
    1085                 1090                 1095             


Thr Thr  His Gln Thr Ser Leu  Glu Leu Phe Met Tyr  Leu Asn Glu 
    1100                 1105                 1110             


Val Ala  Gly Lys His Gly Val  Gly Arg Ile Asp Ile  Val Glu Asn 
    1115                 1120                 1125             


Arg Phe  Ile Gly Met Lys Ser  Arg Gly Ile Tyr Glu  Thr Pro Ala 
    1130                 1135                 1140             


Gly Thr  Ile Leu Tyr His Ala  His Leu Asp Ile Glu  Ala Phe Thr 
    1145                 1150                 1155             


Met Asp  Arg Glu Val Arg Lys  Ile Lys Gln Gly Leu  Gly Leu Lys 
    1160                 1165                 1170             


Phe Ala  Glu Leu Val Tyr Thr  Gly Phe Trp His Ser  Pro Glu Cys 
    1175                 1180                 1185             


Glu Phe  Val Arg His Cys Ile  Ala Lys Ser Gln Glu  Arg Val Glu 
    1190                 1195                 1200             


Gly Lys  Val Gln Val Ser Val  Leu Lys Gly Gln Val  Tyr Ile Leu 
    1205                 1210                 1215             


Gly Arg  Glu Ser Pro Leu Ser  Leu Tyr Asn Glu Glu  Leu Val Ser 
    1220                 1225                 1230             


Met Asn  Val Gln Gly Asp Tyr  Glu Pro Thr Asp Ala  Thr Gly Phe 
    1235                 1240                 1245             


Ile Asn  Ile Asn Ser Leu Arg  Leu Lys Glu Tyr His  Arg Leu Gln 
    1250                 1255                 1260             


Ser Lys  Val Thr Ala Lys Gly  Ser Gly Glu Gly Arg  Gly Ser Leu 
    1265                 1270                 1275             


Leu Thr  Cys Gly Asp Val Glu  Glu Asn Pro Gly Pro  Met Leu Phe 
    1280                 1285                 1290             


Asn Leu  Arg Ile Leu Leu Asn  Asn Ala Ala Phe Arg  Asn Gly His 
    1295                 1300                 1305             


Asn Phe  Met Val Arg Asn Phe  Arg Cys Gly Gln Pro  Leu Gln Asn 
    1310                 1315                 1320             


Lys Val  Gln Leu Lys Gly Arg  Asp Leu Leu Thr Leu  Lys Asn Phe 
    1325                 1330                 1335             


Thr Gly  Glu Glu Ile Lys Tyr  Met Leu Trp Leu Ser  Ala Asp Leu 
    1340                 1345                 1350             


Lys Phe  Arg Ile Lys Gln Lys  Gly Glu Tyr Leu Pro  Leu Leu Gln 
    1355                 1360                 1365             


Gly Lys  Ser Leu Gly Met Ile  Phe Glu Lys Arg Ser  Thr Arg Thr 
    1370                 1375                 1380             


Arg Leu  Ser Thr Glu Thr Gly  Leu Ala Leu Leu Gly  Gly His Pro 
    1385                 1390                 1395             


Cys Phe  Leu Thr Thr Gln Asp  Ile His Leu Gly Val  Asn Glu Ser 
    1400                 1405                 1410             


Leu Thr  Asp Thr Ala Arg Val  Leu Ser Ser Met Ala  Asp Ala Val 
    1415                 1420                 1425             


Leu Ala  Arg Val Tyr Lys Gln  Ser Asp Leu Asp Thr  Leu Ala Lys 
    1430                 1435                 1440             


Glu Ala  Ser Ile Pro Ile Ile  Asn Gly Leu Ser Asp  Leu Tyr His 
    1445                 1450                 1455             


Pro Ile  Gln Ile Leu Ala Asp  Tyr Leu Thr Leu Gln  Glu His Tyr 
    1460                 1465                 1470             


Ser Ser  Leu Lys Gly Leu Thr  Leu Ser Trp Ile Gly  Asp Gly Asn 
    1475                 1480                 1485             


Asn Ile  Leu His Ser Ile Met  Met Ser Ala Ala Lys  Phe Gly Met 
    1490                 1495                 1500             


His Leu  Gln Ala Ala Thr Pro  Lys Gly Tyr Glu Pro  Asp Ala Ser 
    1505                 1510                 1515             


Val Thr  Lys Leu Ala Glu Gln  Tyr Ala Lys Glu Asn  Gly Thr Lys 
    1520                 1525                 1530             


Leu Leu  Leu Thr Asn Asp Pro  Leu Glu Ala Ala His  Gly Gly Asn 
    1535                 1540                 1545             


Val Leu  Ile Thr Asp Thr Trp  Ile Ser Met Gly Gln  Glu Glu Glu 
    1550                 1555                 1560             


Lys Lys  Lys Arg Leu Gln Ala  Phe Gln Gly Tyr Gln  Val Thr Met 
    1565                 1570                 1575             


Lys Thr  Ala Lys Val Ala Ala  Ser Asp Trp Thr Phe  Leu His Cys 
    1580                 1585                 1590             


Leu Pro  Arg Lys Pro Glu Glu  Val Asp Asp Glu Val  Phe Tyr Ser 
    1595                 1600                 1605             


Pro Arg  Ser Leu Val Phe Pro  Glu Ala Glu Asn Arg  Lys Trp Thr 
    1610                 1615                 1620             


Ile Met  Ala Val Met Val Ser  Leu Leu Thr Asp Tyr  Ser Pro Gln 
    1625                 1630                 1635             


Leu Gln  Lys Pro Lys Phe 
    1640                 


<210>  19
<211>  1269
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protein of the invention CD33 ASS1

<400>  19

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Ser Asn Ile 
        355                 360                 365             


Met Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly Glu Lys 
    370                 375                 380                 


Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe Ser Ser Ser 
385                 390                 395                 400 


Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ser Pro 
                405                 410                 415     


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
            420                 425                 430         


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        435                 440                 445             


Ser Val Gln Ser Glu Asp Leu Ala Ile Tyr Tyr Cys His Gln Tyr Leu 
    450                 455                 460                 


Ser Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Val 
                485                 490                 495     


Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val 
            500                 505                 510         


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile 
        515                 520                 525             


His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Val Gly Val 
    530                 535                 540                 


Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe Lys Gly 
545                 550                 555                 560 


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr Met Gln 
                565                 570                 575     


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            580                 585                 590         


Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
        595                 600                 605             


Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    610                 615                 620                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
625                 630                 635                 640 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                645                 650                 655     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            660                 665                 670         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
        675                 680                 685             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    690                 695                 700                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
705                 710                 715                 720 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                725                 730                 735     


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            740                 745                 750         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        755                 760                 765             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    770                 775                 780                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
785                 790                 795                 800 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                805                 810                 815     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            820                 825                 830         


Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        835                 840                 845             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Ser Lys Gly Ser Val 
    850                 855                 860                 


Val Leu Ala Tyr Ser Gly Gly Leu Asp Thr Ser Cys Ile Leu Val Trp 
865                 870                 875                 880 


Leu Lys Glu Gln Gly Tyr Asp Val Ile Ala Tyr Leu Ala Asn Ile Gly 
                885                 890                 895     


Gln Lys Glu Asp Phe Glu Glu Ala Arg Lys Lys Ala Leu Lys Leu Gly 
            900                 905                 910         


Ala Lys Lys Val Phe Ile Glu Asp Val Ser Arg Glu Phe Val Glu Glu 
        915                 920                 925             


Phe Ile Trp Pro Ala Ile Gln Ser Ser Ala Leu Tyr Glu Asp Arg Tyr 
    930                 935                 940                 


Leu Leu Gly Thr Ser Leu Ala Arg Pro Cys Ile Ala Arg Lys Gln Val 
945                 950                 955                 960 


Glu Ile Ala Gln Arg Glu Gly Ala Lys Tyr Val Ser His Gly Ala Thr 
                965                 970                 975     


Gly Lys Gly Asn Asp Gln Val Arg Phe Glu Leu Ser Cys Tyr Ser Leu 
            980                 985                 990         


Ala Pro Gln Ile Lys Val Ile Ala  Pro Trp Arg Met Pro  Glu Phe Tyr 
        995                 1000                 1005             


Asn Arg  Phe Lys Gly Arg Asn  Asp Leu Met Glu Tyr  Ala Lys Gln 
    1010                 1015                 1020             


His Gly  Ile Pro Ile Pro Val  Thr Pro Lys Asn Pro  Trp Ser Met 
    1025                 1030                 1035             


Asp Glu  Asn Leu Met His Ile  Ser Tyr Glu Ala Gly  Ile Leu Glu 
    1040                 1045                 1050             


Asn Pro  Lys Asn Gln Ala Pro  Pro Gly Leu Tyr Thr  Lys Thr Gln 
    1055                 1060                 1065             


Asp Pro  Ala Lys Ala Pro Asn  Thr Pro Asp Ile Leu  Glu Ile Glu 
    1070                 1075                 1080             


Phe Lys  Lys Gly Val Pro Val  Lys Val Thr Asn Val  Lys Asp Gly 
    1085                 1090                 1095             


Thr Thr  His Gln Thr Ser Leu  Glu Leu Phe Met Tyr  Leu Asn Glu 
    1100                 1105                 1110             


Val Ala  Gly Lys His Gly Val  Gly Arg Ile Asp Ile  Val Glu Asn 
    1115                 1120                 1125             


Arg Phe  Ile Gly Met Lys Ser  Arg Gly Ile Tyr Glu  Thr Pro Ala 
    1130                 1135                 1140             


Gly Thr  Ile Leu Tyr His Ala  His Leu Asp Ile Glu  Ala Phe Thr 
    1145                 1150                 1155             


Met Asp  Arg Glu Val Arg Lys  Ile Lys Gln Gly Leu  Gly Leu Lys 
    1160                 1165                 1170             


Phe Ala  Glu Leu Val Tyr Thr  Gly Phe Trp His Ser  Pro Glu Cys 
    1175                 1180                 1185             


Glu Phe  Val Arg His Cys Ile  Ala Lys Ser Gln Glu  Arg Val Glu 
    1190                 1195                 1200             


Gly Lys  Val Gln Val Ser Val  Leu Lys Gly Gln Val  Tyr Ile Leu 
    1205                 1210                 1215             


Gly Arg  Glu Ser Pro Leu Ser  Leu Tyr Asn Glu Glu  Leu Val Ser 
    1220                 1225                 1230             


Met Asn  Val Gln Gly Asp Tyr  Glu Pro Thr Asp Ala  Thr Gly Phe 
    1235                 1240                 1245             


Ile Asn  Ile Asn Ser Leu Arg  Leu Lys Glu Tyr His  Arg Leu Gln 
    1250                 1255                 1260             


Ser Lys  Val Thr Ala Lys 
    1265                 


<210>  20
<211>  1211
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protein of the invention CD33 OTC

<400>  20

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gly Ser Asn Ile 
        355                 360                 365             


Met Leu Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly Glu Lys 
    370                 375                 380                 


Val Thr Met Ser Cys Lys Ser Ser Gln Ser Val Phe Phe Ser Ser Ser 
385                 390                 395                 400 


Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Ile Pro Gly Gln Ser Pro 
                405                 410                 415     


Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp 
            420                 425                 430         


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
        435                 440                 445             


Ser Val Gln Ser Glu Asp Leu Ala Ile Tyr Tyr Cys His Gln Tyr Leu 
    450                 455                 460                 


Ser Ser Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Val 
                485                 490                 495     


Gln Leu Gln Gln Pro Gly Ala Glu Val Val Lys Pro Gly Ala Ser Val 
            500                 505                 510         


Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile 
        515                 520                 525             


His Trp Ile Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Val Gly Val 
    530                 535                 540                 


Ile Tyr Pro Gly Asn Asp Asp Ile Ser Tyr Asn Gln Lys Phe Lys Gly 
545                 550                 555                 560 


Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr Met Gln 
                565                 570                 575     


Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg 
            580                 585                 590         


Glu Val Arg Leu Arg Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val 
        595                 600                 605             


Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
    610                 615                 620                 


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
625                 630                 635                 640 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
                645                 650                 655     


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
            660                 665                 670         


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
        675                 680                 685             


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
    690                 695                 700                 


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
705                 710                 715                 720 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
                725                 730                 735     


Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
            740                 745                 750         


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
        755                 760                 765             


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
    770                 775                 780                 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
785                 790                 795                 800 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
                805                 810                 815     


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
            820                 825                 830         


Pro Pro Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        835                 840                 845             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Leu Phe Asn Leu Arg Ile 
    850                 855                 860                 


Leu Leu Asn Asn Ala Ala Phe Arg Asn Gly His Asn Phe Met Val Arg 
865                 870                 875                 880 


Asn Phe Arg Cys Gly Gln Pro Leu Gln Asn Lys Val Gln Leu Lys Gly 
                885                 890                 895     


Arg Asp Leu Leu Thr Leu Lys Asn Phe Thr Gly Glu Glu Ile Lys Tyr 
            900                 905                 910         


Met Leu Trp Leu Ser Ala Asp Leu Lys Phe Arg Ile Lys Gln Lys Gly 
        915                 920                 925             


Glu Tyr Leu Pro Leu Leu Gln Gly Lys Ser Leu Gly Met Ile Phe Glu 
    930                 935                 940                 


Lys Arg Ser Thr Arg Thr Arg Leu Ser Thr Glu Thr Gly Leu Ala Leu 
945                 950                 955                 960 


Leu Gly Gly His Pro Cys Phe Leu Thr Thr Gln Asp Ile His Leu Gly 
                965                 970                 975     


Val Asn Glu Ser Leu Thr Asp Thr Ala Arg Val Leu Ser Ser Met Ala 
            980                 985                 990         


Asp Ala Val Leu Ala Arg Val Tyr  Lys Gln Ser Asp Leu  Asp Thr Leu 
        995                 1000                 1005             


Ala Lys  Glu Ala Ser Ile Pro  Ile Ile Asn Gly Leu  Ser Asp Leu 
    1010                 1015                 1020             


Tyr His  Pro Ile Gln Ile Leu  Ala Asp Tyr Leu Thr  Leu Gln Glu 
    1025                 1030                 1035             


His Tyr  Ser Ser Leu Lys Gly  Leu Thr Leu Ser Trp  Ile Gly Asp 
    1040                 1045                 1050             


Gly Asn  Asn Ile Leu His Ser  Ile Met Met Ser Ala  Ala Lys Phe 
    1055                 1060                 1065             


Gly Met  His Leu Gln Ala Ala  Thr Pro Lys Gly Tyr  Glu Pro Asp 
    1070                 1075                 1080             


Ala Ser  Val Thr Lys Leu Ala  Glu Gln Tyr Ala Lys  Glu Asn Gly 
    1085                 1090                 1095             


Thr Lys  Leu Leu Leu Thr Asn  Asp Pro Leu Glu Ala  Ala His Gly 
    1100                 1105                 1110             


Gly Asn  Val Leu Ile Thr Asp  Thr Trp Ile Ser Met  Gly Gln Glu 
    1115                 1120                 1125             


Glu Glu  Lys Lys Lys Arg Leu  Gln Ala Phe Gln Gly  Tyr Gln Val 
    1130                 1135                 1140             


Thr Met  Lys Thr Ala Lys Val  Ala Ala Ser Asp Trp  Thr Phe Leu 
    1145                 1150                 1155             


His Cys  Leu Pro Arg Lys Pro  Glu Glu Val Asp Asp  Glu Val Phe 
    1160                 1165                 1170             


Tyr Ser  Pro Arg Ser Leu Val  Phe Pro Glu Ala Glu  Asn Arg Lys 
    1175                 1180                 1185             


Trp Thr  Ile Met Ala Val Met  Val Ser Leu Leu Thr  Asp Tyr Ser 
    1190                 1195                 1200             


Pro Gln  Leu Gln Lys Pro Lys  Phe 
    1205                 1210     


<210>  21
<211>  1651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protein of the invention EGFR ASS1+OTC

<400>  21

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu 
        355                 360                 365             


Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser Leu Lys Leu 
    370                 375                 380                 


Ser Cys Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly Met Ser Trp 
385                 390                 395                 400 


Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser 
                405                 410                 415     


Thr Gly Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe 
            420                 425                 430         


Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser 
        435                 440                 445             


Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr 
    450                 455                 460                 


Ser Ser Thr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
465                 470                 475                 480 


Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val 
            500                 505                 510         


Ala Thr Gly Glu Lys Val Thr Ile Arg Cys Met Thr Ser Thr Asp Ile 
        515                 520                 525             


Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys 
    530                 535                 540                 


Phe Leu Ile Ser Glu Gly Asn Thr Leu Arg Gly Val Pro Ser Arg Phe 
545                 550                 555                 560 


Ser Ser Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr 
                565                 570                 575     


Leu Ser Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Phe Asn Val 
            580                 585                 590         


Pro Leu Thr Phe Gly Asp Gly Thr Lys Leu Glu Lys Ala Leu Glu Gln 
        595                 600                 605             


Lys Leu Ile Ser Glu Glu Asp Leu Ala Lys Pro Thr Thr Thr Pro Ala 
    610                 615                 620                 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
625                 630                 635                 640 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                645                 650                 655     


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            660                 665                 670         


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        675                 680                 685             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    690                 695                 700                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
705                 710                 715                 720 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                725                 730                 735     


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
            740                 745                 750         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        755                 760                 765             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    770                 775                 780                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
785                 790                 795                 800 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                805                 810                 815     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            820                 825                 830         


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn 
        835                 840                 845             


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
    850                 855                 860                 


Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp 
865                 870                 875                 880 


Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile 
                885                 890                 895     


Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg 
            900                 905                 910         


Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val 
        915                 920                 925             


Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser 
    930                 935                 940                 


Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala Arg Pro 
945                 950                 955                 960 


Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys 
                965                 970                 975     


Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe 
            980                 985                 990         


Glu Leu Ser Cys Tyr Ser Leu Ala  Pro Gln Ile Lys Val  Ile Ala Pro 
        995                 1000                 1005             


Trp Arg  Met Pro Glu Phe Tyr  Asn Arg Phe Lys Gly  Arg Asn Asp 
    1010                 1015                 1020             


Leu Met  Glu Tyr Ala Lys Gln  His Gly Ile Pro Ile  Pro Val Thr 
    1025                 1030                 1035             


Pro Lys  Asn Pro Trp Ser Met  Asp Glu Asn Leu Met  His Ile Ser 
    1040                 1045                 1050             


Tyr Glu  Ala Gly Ile Leu Glu  Asn Pro Lys Asn Gln  Ala Pro Pro 
    1055                 1060                 1065             


Gly Leu  Tyr Thr Lys Thr Gln  Asp Pro Ala Lys Ala  Pro Asn Thr 
    1070                 1075                 1080             


Pro Asp  Ile Leu Glu Ile Glu  Phe Lys Lys Gly Val  Pro Val Lys 
    1085                 1090                 1095             


Val Thr  Asn Val Lys Asp Gly  Thr Thr His Gln Thr  Ser Leu Glu 
    1100                 1105                 1110             


Leu Phe  Met Tyr Leu Asn Glu  Val Ala Gly Lys His  Gly Val Gly 
    1115                 1120                 1125             


Arg Ile  Asp Ile Val Glu Asn  Arg Phe Ile Gly Met  Lys Ser Arg 
    1130                 1135                 1140             


Gly Ile  Tyr Glu Thr Pro Ala  Gly Thr Ile Leu Tyr  His Ala His 
    1145                 1150                 1155             


Leu Asp  Ile Glu Ala Phe Thr  Met Asp Arg Glu Val  Arg Lys Ile 
    1160                 1165                 1170             


Lys Gln  Gly Leu Gly Leu Lys  Phe Ala Glu Leu Val  Tyr Thr Gly 
    1175                 1180                 1185             


Phe Trp  His Ser Pro Glu Cys  Glu Phe Val Arg His  Cys Ile Ala 
    1190                 1195                 1200             


Lys Ser  Gln Glu Arg Val Glu  Gly Lys Val Gln Val  Ser Val Leu 
    1205                 1210                 1215             


Lys Gly  Gln Val Tyr Ile Leu  Gly Arg Glu Ser Pro  Leu Ser Leu 
    1220                 1225                 1230             


Tyr Asn  Glu Glu Leu Val Ser  Met Asn Val Gln Gly  Asp Tyr Glu 
    1235                 1240                 1245             


Pro Thr  Asp Ala Thr Gly Phe  Ile Asn Ile Asn Ser  Leu Arg Leu 
    1250                 1255                 1260             


Lys Glu  Tyr His Arg Leu Gln  Ser Lys Val Thr Ala  Lys Gly Ser 
    1265                 1270                 1275             


Gly Glu  Gly Arg Gly Ser Leu  Leu Thr Cys Gly Asp  Val Glu Glu 
    1280                 1285                 1290             


Asn Pro  Gly Pro Met Leu Phe  Asn Leu Arg Ile Leu  Leu Asn Asn 
    1295                 1300                 1305             


Ala Ala  Phe Arg Asn Gly His  Asn Phe Met Val Arg  Asn Phe Arg 
    1310                 1315                 1320             


Cys Gly  Gln Pro Leu Gln Asn  Lys Val Gln Leu Lys  Gly Arg Asp 
    1325                 1330                 1335             


Leu Leu  Thr Leu Lys Asn Phe  Thr Gly Glu Glu Ile  Lys Tyr Met 
    1340                 1345                 1350             


Leu Trp  Leu Ser Ala Asp Leu  Lys Phe Arg Ile Lys  Gln Lys Gly 
    1355                 1360                 1365             


Glu Tyr  Leu Pro Leu Leu Gln  Gly Lys Ser Leu Gly  Met Ile Phe 
    1370                 1375                 1380             


Glu Lys  Arg Ser Thr Arg Thr  Arg Leu Ser Thr Glu  Thr Gly Leu 
    1385                 1390                 1395             


Ala Leu  Leu Gly Gly His Pro  Cys Phe Leu Thr Thr  Gln Asp Ile 
    1400                 1405                 1410             


His Leu  Gly Val Asn Glu Ser  Leu Thr Asp Thr Ala  Arg Val Leu 
    1415                 1420                 1425             


Ser Ser  Met Ala Asp Ala Val  Leu Ala Arg Val Tyr  Lys Gln Ser 
    1430                 1435                 1440             


Asp Leu  Asp Thr Leu Ala Lys  Glu Ala Ser Ile Pro  Ile Ile Asn 
    1445                 1450                 1455             


Gly Leu  Ser Asp Leu Tyr His  Pro Ile Gln Ile Leu  Ala Asp Tyr 
    1460                 1465                 1470             


Leu Thr  Leu Gln Glu His Tyr  Ser Ser Leu Lys Gly  Leu Thr Leu 
    1475                 1480                 1485             


Ser Trp  Ile Gly Asp Gly Asn  Asn Ile Leu His Ser  Ile Met Met 
    1490                 1495                 1500             


Ser Ala  Ala Lys Phe Gly Met  His Leu Gln Ala Ala  Thr Pro Lys 
    1505                 1510                 1515             


Gly Tyr  Glu Pro Asp Ala Ser  Val Thr Lys Leu Ala  Glu Gln Tyr 
    1520                 1525                 1530             


Ala Lys  Glu Asn Gly Thr Lys  Leu Leu Leu Thr Asn  Asp Pro Leu 
    1535                 1540                 1545             


Glu Ala  Ala His Gly Gly Asn  Val Leu Ile Thr Asp  Thr Trp Ile 
    1550                 1555                 1560             


Ser Met  Gly Gln Glu Glu Glu  Lys Lys Lys Arg Leu  Gln Ala Phe 
    1565                 1570                 1575             


Gln Gly  Tyr Gln Val Thr Met  Lys Thr Ala Lys Val  Ala Ala Ser 
    1580                 1585                 1590             


Asp Trp  Thr Phe Leu His Cys  Leu Pro Arg Lys Pro  Glu Glu Val 
    1595                 1600                 1605             


Asp Asp  Glu Val Phe Tyr Ser  Pro Arg Ser Leu Val  Phe Pro Glu 
    1610                 1615                 1620             


Ala Glu  Asn Arg Lys Trp Thr  Ile Met Ala Val Met  Val Ser Leu 
    1625                 1630                 1635             


Leu Thr  Asp Tyr Ser Pro Gln  Leu Gln Lys Pro Lys  Phe 
    1640                 1645                 1650     


<210>  22
<211>  1276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protein of the invention EGFR ASS1

<400>  22

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu 
        355                 360                 365             


Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser Leu Lys Leu 
    370                 375                 380                 


Ser Cys Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly Met Ser Trp 
385                 390                 395                 400 


Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser 
                405                 410                 415     


Thr Gly Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe 
            420                 425                 430         


Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser 
        435                 440                 445             


Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr 
    450                 455                 460                 


Ser Ser Thr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
465                 470                 475                 480 


Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val 
            500                 505                 510         


Ala Thr Gly Glu Lys Val Thr Ile Arg Cys Met Thr Ser Thr Asp Ile 
        515                 520                 525             


Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys 
    530                 535                 540                 


Phe Leu Ile Ser Glu Gly Asn Thr Leu Arg Gly Val Pro Ser Arg Phe 
545                 550                 555                 560 


Ser Ser Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr 
                565                 570                 575     


Leu Ser Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Phe Asn Val 
            580                 585                 590         


Pro Leu Thr Phe Gly Asp Gly Thr Lys Leu Glu Lys Ala Leu Glu Gln 
        595                 600                 605             


Lys Leu Ile Ser Glu Glu Asp Leu Ala Lys Pro Thr Thr Thr Pro Ala 
    610                 615                 620                 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
625                 630                 635                 640 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                645                 650                 655     


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            660                 665                 670         


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        675                 680                 685             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    690                 695                 700                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
705                 710                 715                 720 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                725                 730                 735     


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
            740                 745                 750         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        755                 760                 765             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    770                 775                 780                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
785                 790                 795                 800 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                805                 810                 815     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            820                 825                 830         


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn 
        835                 840                 845             


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
    850                 855                 860                 


Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp 
865                 870                 875                 880 


Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile 
                885                 890                 895     


Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg 
            900                 905                 910         


Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val 
        915                 920                 925             


Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser 
    930                 935                 940                 


Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala Arg Pro 
945                 950                 955                 960 


Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys 
                965                 970                 975     


Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe 
            980                 985                 990         


Glu Leu Ser Cys Tyr Ser Leu Ala  Pro Gln Ile Lys Val  Ile Ala Pro 
        995                 1000                 1005             


Trp Arg  Met Pro Glu Phe Tyr  Asn Arg Phe Lys Gly  Arg Asn Asp 
    1010                 1015                 1020             


Leu Met  Glu Tyr Ala Lys Gln  His Gly Ile Pro Ile  Pro Val Thr 
    1025                 1030                 1035             


Pro Lys  Asn Pro Trp Ser Met  Asp Glu Asn Leu Met  His Ile Ser 
    1040                 1045                 1050             


Tyr Glu  Ala Gly Ile Leu Glu  Asn Pro Lys Asn Gln  Ala Pro Pro 
    1055                 1060                 1065             


Gly Leu  Tyr Thr Lys Thr Gln  Asp Pro Ala Lys Ala  Pro Asn Thr 
    1070                 1075                 1080             


Pro Asp  Ile Leu Glu Ile Glu  Phe Lys Lys Gly Val  Pro Val Lys 
    1085                 1090                 1095             


Val Thr  Asn Val Lys Asp Gly  Thr Thr His Gln Thr  Ser Leu Glu 
    1100                 1105                 1110             


Leu Phe  Met Tyr Leu Asn Glu  Val Ala Gly Lys His  Gly Val Gly 
    1115                 1120                 1125             


Arg Ile  Asp Ile Val Glu Asn  Arg Phe Ile Gly Met  Lys Ser Arg 
    1130                 1135                 1140             


Gly Ile  Tyr Glu Thr Pro Ala  Gly Thr Ile Leu Tyr  His Ala His 
    1145                 1150                 1155             


Leu Asp  Ile Glu Ala Phe Thr  Met Asp Arg Glu Val  Arg Lys Ile 
    1160                 1165                 1170             


Lys Gln  Gly Leu Gly Leu Lys  Phe Ala Glu Leu Val  Tyr Thr Gly 
    1175                 1180                 1185             


Phe Trp  His Ser Pro Glu Cys  Glu Phe Val Arg His  Cys Ile Ala 
    1190                 1195                 1200             


Lys Ser  Gln Glu Arg Val Glu  Gly Lys Val Gln Val  Ser Val Leu 
    1205                 1210                 1215             


Lys Gly  Gln Val Tyr Ile Leu  Gly Arg Glu Ser Pro  Leu Ser Leu 
    1220                 1225                 1230             


Tyr Asn  Glu Glu Leu Val Ser  Met Asn Val Gln Gly  Asp Tyr Glu 
    1235                 1240                 1245             


Pro Thr  Asp Ala Thr Gly Phe  Ile Asn Ile Asn Ser  Leu Arg Leu 
    1250                 1255                 1260             


Lys Glu  Tyr His Arg Leu Gln  Ser Lys Val Thr Ala  Lys 
    1265                 1270                 1275     


<210>  23
<211>  1218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protein of the invention EGFR OTC

<400>  23

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu 
        355                 360                 365             


Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser Leu Lys Leu 
    370                 375                 380                 


Ser Cys Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly Met Ser Trp 
385                 390                 395                 400 


Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala Ser Ile Ser 
                405                 410                 415     


Thr Gly Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys Gly Arg Phe 
            420                 425                 430         


Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser 
        435                 440                 445             


Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Arg Gly Tyr 
    450                 455                 460                 


Ser Ser Thr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
465                 470                 475                 480 


Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser Leu Ser Val 
            500                 505                 510         


Ala Thr Gly Glu Lys Val Thr Ile Arg Cys Met Thr Ser Thr Asp Ile 
        515                 520                 525             


Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu Pro Pro Lys 
    530                 535                 540                 


Phe Leu Ile Ser Glu Gly Asn Thr Leu Arg Gly Val Pro Ser Arg Phe 
545                 550                 555                 560 


Ser Ser Ser Gly Thr Gly Thr Asp Phe Val Phe Thr Ile Glu Asn Thr 
                565                 570                 575     


Leu Ser Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln Ser Phe Asn Val 
            580                 585                 590         


Pro Leu Thr Phe Gly Asp Gly Thr Lys Leu Glu Lys Ala Leu Glu Gln 
        595                 600                 605             


Lys Leu Ile Ser Glu Glu Asp Leu Ala Lys Pro Thr Thr Thr Pro Ala 
    610                 615                 620                 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
625                 630                 635                 640 


Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                645                 650                 655     


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
            660                 665                 670         


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
        675                 680                 685             


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
    690                 695                 700                 


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
705                 710                 715                 720 


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
                725                 730                 735     


Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn 
            740                 745                 750         


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
        755                 760                 765             


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
    770                 775                 780                 


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
785                 790                 795                 800 


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
                805                 810                 815     


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
            820                 825                 830         


Ala Leu His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Ala Thr Asn 
        835                 840                 845             


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
    850                 855                 860                 


Met Leu Phe Asn Leu Arg Ile Leu Leu Asn Asn Ala Ala Phe Arg Asn 
865                 870                 875                 880 


Gly His Asn Phe Met Val Arg Asn Phe Arg Cys Gly Gln Pro Leu Gln 
                885                 890                 895     


Asn Lys Val Gln Leu Lys Gly Arg Asp Leu Leu Thr Leu Lys Asn Phe 
            900                 905                 910         


Thr Gly Glu Glu Ile Lys Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys 
        915                 920                 925             


Phe Arg Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys 
    930                 935                 940                 


Ser Leu Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser 
945                 950                 955                 960 


Thr Glu Thr Gly Leu Ala Leu Leu Gly Gly His Pro Cys Phe Leu Thr 
                965                 970                 975     


Thr Gln Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr Asp Thr Ala 
            980                 985                 990         


Arg Val Leu Ser Ser Met Ala Asp  Ala Val Leu Ala Arg  Val Tyr Lys 
        995                 1000                 1005             


Gln Ser  Asp Leu Asp Thr Leu  Ala Lys Glu Ala Ser  Ile Pro Ile 
    1010                 1015                 1020             


Ile Asn  Gly Leu Ser Asp Leu  Tyr His Pro Ile Gln  Ile Leu Ala 
    1025                 1030                 1035             


Asp Tyr  Leu Thr Leu Gln Glu  His Tyr Ser Ser Leu  Lys Gly Leu 
    1040                 1045                 1050             


Thr Leu  Ser Trp Ile Gly Asp  Gly Asn Asn Ile Leu  His Ser Ile 
    1055                 1060                 1065             


Met Met  Ser Ala Ala Lys Phe  Gly Met His Leu Gln  Ala Ala Thr 
    1070                 1075                 1080             


Pro Lys  Gly Tyr Glu Pro Asp  Ala Ser Val Thr Lys  Leu Ala Glu 
    1085                 1090                 1095             


Gln Tyr  Ala Lys Glu Asn Gly  Thr Lys Leu Leu Leu  Thr Asn Asp 
    1100                 1105                 1110             


Pro Leu  Glu Ala Ala His Gly  Gly Asn Val Leu Ile  Thr Asp Thr 
    1115                 1120                 1125             


Trp Ile  Ser Met Gly Gln Glu  Glu Glu Lys Lys Lys  Arg Leu Gln 
    1130                 1135                 1140             


Ala Phe  Gln Gly Tyr Gln Val  Thr Met Lys Thr Ala  Lys Val Ala 
    1145                 1150                 1155             


Ala Ser  Asp Trp Thr Phe Leu  His Cys Leu Pro Arg  Lys Pro Glu 
    1160                 1165                 1170             


Glu Val  Asp Asp Glu Val Phe  Tyr Ser Pro Arg Ser  Leu Val Phe 
    1175                 1180                 1185             


Pro Glu  Ala Glu Asn Arg Lys  Trp Thr Ile Met Ala  Val Met Val 
    1190                 1195                 1200             


Ser Leu  Leu Thr Asp Tyr Ser  Pro Gln Leu Gln Lys  Pro Lys Phe 
    1205                 1210                 1215             


<210>  24
<211>  1236
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding ASS1

<400>  24
atgtccagca aaggctccgt ggttctggcc tacagtggcg gcctggacac ctcgtgcatc       60

ctcgtgtggc tgaaggaaca aggctatgac gtcattgcct atctggccaa cattggccag      120

aaggaagact tcgaggaagc caggaagaag gcactgaaac ttggggccaa aaaggtgttc      180

attgaggatg tcagcaggga gtttgtggag gagttcatct ggccggccat ccagtccagc      240

gcactgtatg aggaccgcta cctcctgggc acctctcttg ccaggccctg catcgcccgc      300

aaacaagtgg aaatcgccca gcgggagggg gccaagtatg tgtcccacgg cgccacagga      360

aaggggaacg atcaggtccg gtttgagctc agctgctact cactggcccc ccagataaag      420

gtcattgctc cctggaggat gcctgaattc tacaaccggt tcaagggccg caatgacctg      480

atggagtacg caaagcaaca cgggattccc atcccggtca ctcccaagaa cccgtggagc      540

atggatgaga acctcatgca catcagctac gaggctggaa tcctggagaa ccccaagaac      600

caagcgcctc caggtctcta cacgaagacc caggacccag ccaaagcccc caacacccct      660

gacattctcg agatcgagtt caaaaaaggg gtccctgtga aggtgaccaa cgtcaaggat      720

ggcaccaccc accagacctc cttggagctc ttcatgtacc tgaacgaagt cgcgggcaag      780

catggcgtgg gccgtattga catcgtggag aaccgcttca ttggaatgaa gtcccgaggt      840

atctacgaga ccccagcagg caccatcctt taccatgctc atttagacat cgaggccttc      900

accatggacc gggaagtgcg caaaatcaaa caaggcctgg gcttgaaatt tgctgagctg      960

gtgtataccg gtttctggca cagccctgag tgtgaatttg tccgccactg catcgccaag     1020

tcccaggagc gagtggaagg gaaagtgcag gtgtccgtcc tcaagggcca ggtgtacatc     1080

ctcggccggg agtccccact gtctctctac aatgaggagc tggtgagcat gaacgtgcag     1140

ggtgattatg agccaactga tgccaccggg ttcatcaaca tcaattccct caggctgaag     1200

gaatatcatc gtctccagag caaggtcact gccaaa                               1236


<210>  25
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding OTC

<400>  25
atgctgttta atctgaggat cctgttaaac aatgcagctt ttagaaatgg tcacaacttc       60

atggttcgaa attttcggtg tggacaacca ctacaaaata aagtgcagct gaagggccgt      120

gaccttctca ctctaaaaaa ctttaccgga gaagaaatta aatatatgct atggctatca      180

gcagatctga aatttaggat aaaacagaaa ggagagtatt tgcctttatt gcaagggaag      240

tccttaggca tgatttttga gaaaagaagt actcgaacaa gattgtctac agaaacaggc      300

ttagcacttc tgggaggaca tccttgtttt cttaccacac aagatattca tttgggtgtg      360

aatgaaagtc tcacggacac ggcccgtgta ttgtctagca tggcagatgc agtattggct      420

cgagtgtata aacaatcaga tttggacacc ctggctaaag aagcatccat cccaattatc      480

aatgggctgt cagatttgta ccatcctatc cagatcctgg ctgattacct cacgctccag      540

gaacactata gctctctgaa aggtcttacc ctcagctgga tcggggatgg gaacaatatc      600

ctgcactcca tcatgatgag cgcagcgaaa ttcggaatgc accttcaggc agctactcca      660

aagggttatg agccggatgc tagtgtaacc aagttggcag agcagtatgc caaagagaat      720

ggtaccaagc tgttgctgac aaatgatcca ttggaagcag cgcatggagg caatgtatta      780

attacagaca cttggataag catgggacaa gaagaggaga agaaaaagcg gctccaggct      840

ttccaaggtt accaggttac aatgaagact gctaaagttg ctgcctctga ctggacattt      900

ttacactgct tgcccagaaa gccagaagaa gtggatgatg aagtctttta ttctcctcga      960

tcactagtgt tcccagaggc agaaaacaga aagtggacaa tcatggctgt catggtgtcc     1020

ctgctgacag attactcacc tcagctccag aagcctaaat tt                        1062


<210>  26
<211>  789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding GD2 scFv

<400>  26
gatattctgc tcacacagac cccactctcc ctgcccgtgt cactcgggga tcaggctagc       60

atttcttgcc gctcatctca gtctctggtc caccggaatg ggaacacata cctccattgg      120

tacctccaga aacctggaca gagccctaaa ctgctcatcc acaaagtctc aaatcggttc      180

tccggcgtgc ccgatcgctt tagcggatcc ggatctggga ccgacttcac actgaaaatc      240

tcacgagtgg aggctgagga tctcggcgtc tacttctgta gtcagagtac ccacgtccca      300

cccctcacct ttggcgctgg aacaaaactg gagctgaaac gagccgatgc tgctcctacc      360

gtgtccatct ttcctggctc cgggggaggc gggagcggag gcgaagtgaa actccagcag      420

tctggccctt ctctcgtgga acctggcgct tctgtgatga tctcctgtaa ggcctctgga      480

tcttccttta ccggctacaa catgaactgg gtccggcaga acattggcaa atccctggaa      540

tggattggcg ccatcgatcc ttactacggc ggcacatcat acaatcagaa attcaagggg      600

cgagcaacac tcactgtcga caaatcttca tccaccgcct acatgcacct gaaatctctc      660

acatccgagg atagtgctgt ctactactgt gtctctggca tggaatactg gggacaggga      720

acttctgtca ccgtgtctag tgccaaaacc acacctccct ccgtgtacgg acgagtcact      780

gtctcatct                                                              789


<210>  27
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding CD33 scFv

<400>  27
ggatccaaca tcatgctgac ccagagccct agcagcctgg ccgtgtctgc cggcgagaaa       60

gtgaccatga gctgcaagag cagccagagc gtgttcttca gcagctccca gaagaactac      120

ctagcctggt atcagcagat cccaggccag agccctaagc tgctgatcta ctgggccagc      180

accagagaaa gcggcgtgcc cgatagattc accggaagcg gttctggcac cgacttcacc      240

ctgacaatca gcagcgtgca gagcgaggac ctggccatct actactgcca ccagtacctg      300

agcagccgga cctttggcgg aggcaccaag ctggaaatca agagaggcgg cggaggctca      360

ggcggaggcg gatctagtgg cggaggatct caggtgcagc tgcagcagcc aggcgccgag      420

gtcgtgaaac ctggcgcctc tgtgaagatg tcctgcaagg ccagcggcta caccttcacc      480

agctactaca tccactggat caagcagacc cctggacagg gcctggaatg ggtgggagtg      540

atctaccccg gcaacgacga catcagctac aaccagaagt tcaagggcaa ggccaccctg      600

accgccgaca agtctagcac caccgcctac atgcagctgt ccagcctgac cagcgaggac      660

agcgccgtgt actactgcgc cagagaagtg cggctgcggt acttcgatgt gtggggagcc      720

ggcaccaccg tgaccgtgtc atct                                             744


<210>  28
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding Mesothelin scFv

<400>  28
atgcaggtac aactgcagca gtctgggcct gagctggaga agcctggcgc ttcagtgaag       60

atatcctgca aggcttctgg ttactcattc actggctaca ccatgaactg ggtgaagcag      120

agccatggaa agagccttga gtggattgga cttattactc cttacaatgg tgcttctagc      180

tacaaccaga agttcagggg caaggccaca ttaactgtag acaagtcatc cagcacagcc      240

tacatggacc tcctcagtct gacatctgaa gactctgcag tctatttctg tgcaaggggg      300

ggttacgacg ggaggggttt tgactactgg ggccaaggga ccacggtcac cgtctcctca      360

ggtgtaggcg gttcaggcgg cggtggctct ggcggtggcg gatcggacat cgagctcact      420

cagtctccag caatcatgtc tgcatctcca ggggagaagg tcaccatgac ctgcagtgcc      480

agctcaagtg taagttacat gcactggtac cagcagaagt caggcacctc ccccaaaaga      540

tggatttatg acacatccaa actggcttct ggagtcccag gtcgcttcag tggcagtggg      600

tctggaaact cttactctct cacaatcagc agcgtggagg ctgaagatga tgcaacttat      660

tactgccagc agtggagtgg ttaccctctc acgttcggtg ctgggacaaa gttggaaata      720

aaa                                                                    723


<210>  29
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding EGFRvIII scFv

<400>  29
caggtacaac tccagcagtc tgggggaggc ttagtgaagc ctggagcgtc tctgaaactc       60

tcctgtgtaa cctctggatt cactttcaga aaatttggca tgtcttgggt tcgccagact      120

agtgacaaga ggctggaatg ggtcgcatcc attagtactg gcggttataa cacgtactat      180

tcagacaatg taaagggccg attcaccatc tccagagaga atgccaagaa caccctgtac      240

ctgcaaatga gtagtctgaa gtctgaggac acggccttgt attactgtac aagaggctat      300

tctagtacct cttatgctat ggactactgg ggccaaggga ccacggtcac cgtctcctca      360

agtggaggcg gttcaggcgg aggtggctct ggcggtggcg gatcggacat cgagctcact      420

cagtctccag catccctgtc cgtggctaca ggagaaaaag tcactatcag atgcatgacc      480

agcactgata ttgatgatga tatgaactgg taccagcaga agccagggga accccctaag      540

ttccttattt cagaaggcaa tactcttcgg ccgggagtcc catcccgatt ttccagcagt      600

ggcactggca cagattttgt ttttacaatt gaaaacacac tctcggaaga tgttggagat      660

tactactgtt tgcaaagctt taacgtgcct cttacattcg gtgatggcac caagcttgaa      720

aaagctctag agcagaaact gatctcggaa gaagatctgg cgaagccc                   768


<210>  30
<211>  17555
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding ASL

<400>  30
gacgccatcc cggccagaaa agccctggcc agtggcgggc gcgacactat ccgtgcggcc       60

aggcggaggt gagtgcgcgg cggccggatg ggcgggacgg gcgtggagga cgccgagcac      120

cgtggcgcgc gctcacgtcc gcgtccccaa gggctgcgct ccctcaagcg cagtgcccag      180

aactcggagc cagcccggcc cgggggaccc tgctggccaa ggaggtcgtc agtccggtct      240

tgtcttccag acccggagga ccgaagcttc cggacgacga ggaaccgccc aacatggcct      300

cggaggtgag tgggacctcg gggactccgg tcctcctagc ctccaaagga gagagtgggg      360

gcgccagacc tgcctcgggc caccctgctg ggaatcgccc tccaggaagc aattttgaaa      420

attacctagg aagcctgcac ccccagccct cccgggcgca tcatctggag cccagcagtc      480

acctttacca ggactcacca gtatccgcag gcagcccttg tggcaaaccc accaacccac      540

actactaggg gtagagtggc tctgccctca cctcacagtg atgcctgcct ggccaggaaa      600

agtggctccc aagccttcag ccttccaact cttccttcct tcttaccacg tgtcctcctg      660

tcaggtccca ccccacacca catcccttct cctgctagag caattgtccc tgtttataga      720

ataaagctca gcccctaagt gttcttgtcc ttgactgtgg catgtggaaa gagccaggaa      780

aaaggggacg tcgcctcgtg gctccagcaa ccctggtgcc tggtcccttc ctgtctcact      840

ggaccctgcc tcttagggtc agtggctcct ggcctctcct cctgaccact gagatgctgg      900

attcccaggc agaggttttc cttccttggg ccatagttga tttatctggc aatgggggta      960

ataatagctg tcggcctcac tctgtaaggc actagattat gaggccattg ctttggaccc     1020

ttcaggtgag aggggctgtt cgcctgatgc ttgatgaagg gaactccggg aagcaggagg     1080

tctgggttcc aggccctttt ggccttcatt agctagcaat tcacttcctc tttctcaatg     1140

ccctgcaagc tcagtgccct gcaagcttct gggtcatggc aggggggtag ggcctggact     1200

ttggagccaa acagacttgg tttctgtacc agtcacttga gccctttaaa cctctttcct     1260

catttgtgaa ataggggtaa tattgcccac ctcataaaag gccgtaataa catatgtgaa     1320

atccctagca cagggctgag caacagtagg tgctcaataa atggtggcta accacaacaa     1380

tactgatatt tctactttgg gaggccgagg cgggaggact gctgaagccc aggaattcca     1440

gaccagccag ggcaatgtaa tgagaccctg tctctacaaa aagattttga aaattaccca     1500

ggtgtggtgg cgtacacctg tagtctcaca ggaggcggag gcatgaggat tgcttgagcc     1560

caggagtttg agactgcagt gagcatgatc tcaccactgc actccagccc aggcaacaga     1620

gtgagatcca gtttcaaaaa aataaaaata aaaaaacctg gcaggcatgg tggctcacac     1680

ctgtaatccc agcactttgg gaggtcgagg tgggcagatc acctgaggtc aggagtttga     1740

gaccagcctg gccaacatgg tgaaaccccg tctctactaa aaatgcaaaa attagctggg     1800

tgtagtggtg ggtgcctgta gtcccagcta ttcgggaggc tgaggcagga gaatcgcttg     1860

aactcgggag gcggaggttg cagtgagctg agatcgcacc actgcactcc agcctgggcg     1920

acaaagcaag actccacctc aaaaaaagaa aaaaaaccca caagtcccaa aaccaaaact     1980

ggtatttccc atgtacattc gaccttaact gttgctcatt caacccagcc caactcagtg     2040

ccccatcccc tggccctgaa gagaccattc tggcccagat gtgtcctggc ttggagtagc     2100

accttctgct accacactag gcctccactc tcctcagtgc ccaaggggag gcacctcact     2160

ctgatctccc tgtggggtcc tcttatgcct gccagtaagg ataggagttt ggttctagag     2220

cagagtggtc tggcttccaa caagcccagt gttctaggtg acctcaggtt gccccaggcc     2280

ttcctgtagg ttggcactaa ttggtttggc tgcagctcca cttattaagt agttattttt     2340

attactaaca acctaggcag ggtggcccag gagcccgctg ggggaggcgg tgccaggctc     2400

ctggctgagg ggcaggctgg ccccaattct gactggctgg ctccagtgat caggaccagg     2460

gccccacgtg gtgctttgct ggagatctag gcttggtggg gcagctgtgg ggtaaggggc     2520

aggaccagct caaagatggg gtgggggcgg aggctgcctc tgcagggcag agtcctttgg     2580

cagtcgggac tgttgggcat agaggagtca gctcacagct cagggccaga gcactggaga     2640

ggtctctggg gtgcatacag gaaccaggag tggagctgaa gcatgtccta tcccctgcca     2700

gccctccctt agtaacagct ggcatttctc gagtccttcc tgagcaccag gcaccgtgtt     2760

atgtatgcaa tttgcaaata ttatctgatt aaatgctcac aataaggcta tcagagaggt     2820

actattatta tccttatctt attattatta ttattattat ttttaagaag gagtcttgct     2880

ctgtcgccca agctggagta caatggcgcc atctctgctc accgcaacct ctacctccag     2940

gattcaagtg attctcctgc ttcagactcc caagtggctg ggactacagc ttcctgccac     3000

cgcgcctggc taatgtttat atttttagta cagatgaggt ttcaccatgt tggccaggct     3060

gatctcgaac tcctgacctc aagcgatcca cctgcctggg cctcccaacc ctgagggttt     3120

ttgtttttgt ttttgttttg agacagagtc ttgctctgtc gcccaggctg gagtgcagtg     3180

gcacgatctc agctcactgc aagctccgcc tcccgggttc acgccattct cctgcctcag     3240

cctcccaagt agctgggact acaggcgccc aacaccccca tgcctggcta atttttttgt     3300

gtgtgttttc agtagagacg gagtttcacc atgttagcca ggatggtctc catctcctga     3360

cctcgtgatc tgcccacctc agcctcccaa agtgctagga ttataggtgt gagccaccac     3420

gcccagcccc tgaggtttaa taataggtgc caggccaggt ggttaataga agtctggggc     3480

attgtagggg gacagaggag gatatatgtc cccattggcc attgtagact cccttccaca     3540

aaaaggacgt cagtgaagtg acatgcccac ctctacccca ccctcctccc agtcctgggc     3600

actagggctg ctccccaggt gttctgtacc ccctccccac tctgtcccat gccctggcct     3660

ctgccctctt tcaaaacata gatgtggctg gcgcctaggc tcatgcctat aatctcagca     3720

ctttgggaag ctgaggctgg aggacagctt gagcccagga attcaagacc agcctgggca     3780

acatagtgag accctgtctc taccaattat tttattttat tttattttgt tcatttattt     3840

atttattttg agacagagtt ttgctctgtc acctaggctg gagtgcagtg gcgtgatctt     3900

ggctcactgc aacctccgcc tcccgggttc aagcgattct cctgcctcag cctcctaagt     3960

agctggaact acaggcgagt gccaccacgc ctggctaatt tttgtatttt tagtagagac     4020

caggtttcac catgttgacc aggatggtct ctgtctcctg acctcatgat ccacccacct     4080

tagccttcca aaatgctggg attacaggca tgagccacca ctcccagtcc tataaaattt     4140

taaaaaaatg tctgggtgtg gtggcgcatg cttgtagtcc caactattgg ggaggctgag     4200

gcaagaggat tggttgagac caggagtttg aggctgcagt gagctatgat ggtgccaccg     4260

cactccaacc tgggtaacaa agtgagaccc tgtgtctaaa aaagaattta aaggccgggt     4320

gtggtggctc acacccgtaa tcccaggact ttgggaggcc gaggtgggca gatcacgagg     4380

tcagattaag accatcctgg ctaacaaggt gaaaccacgt ctctactgaa aaaaaaaaat     4440

acaaaaaatt agccaggcat ggtggtgggc acctgtagtc ccagctactc aggaggctga     4500

ggcaggagaa tggcgtgaat ctgggaggtg gagcttgcag tgagccaaga tcctgccact     4560

gcactccagc ctgggtgaca aagagagact ccatctcaaa aaaaaaaaaa aaaaaaaaga     4620

attaaaaaag atttttttaa tgaacaaaac aggctcggca cagtggctca tgcctgtaat     4680

cccaagcact tcgggatgcc aaggtcaggg gatcacctga gatcaggagt tcgagaccag     4740

cctgaccaac atggtgaaac cccgtctcta ctaaaaatat aaaactcagc caggtgtggt     4800

ggcacacgcc tgaaattcca gctactcggg aggctgaggc aggaaaattg gcttgaagcc     4860

gggaggtgga ggttgcagtg agccgagatc acgccactgc actccagcct aggcaacaga     4920

gtgagactct atctcaaaga aaacgaacaa aacatagatg cctacatacc attcctctgc     4980

ccttggctcc tggggagtaa gggatcaccc agtgacctcc tagaaggcca gtgacaatgg     5040

ggggtgtcag ggtgcttttc agagccaagg gagtggtagg aattgggatc ttagtccagc     5100

tccaagctgt gagggagaga gttgcagggc acttaagctt ggtggagacc ctcaaggcct     5160

ctttgcctgt ccctgcagca aaggttctgg acaccagagc caagtccaga agccctggtg     5220

gaacaggggt gaaaagcata ggttctgact tcagactgct gggccgcagc cctggctatc     5280

ccaccccagg tgagagcagg ctgctctgtg cctcagtttc cccatcttca tagtggaatt     5340

gtattggtgc ctacccagag ggttgtgtca acaattagga tggcacctag caccttggtc     5400

agtggtggga aaggttccag aagttctgct gtggtcccag gggtgtctca ggccctgcca     5460

tcatctcctt ggaggggtgc catgtggtgg gaaagaaccc caacttcaag gccacacaca     5520

gtggctcatg cctgtaatcc tagcactttc agaggccaag atgggaggat cacctgaggt     5580

caggagttca agaccagcct ggccaacatg gtgaaacccc atctctacta atgatacaaa     5640

aattagctgg gtgtggtggc acgtgcctgt aatcccagct acttgggagt ctgaggcagg     5700

agaatctctt gaacctggga ggcagagttt gcagtgagct gagatggcac cactgtactc     5760

cagcctggcc gacaaagtga gactctgtct caaaaaaaaa aaaaaagaac ccaaactttt     5820

ggtgttcagc catgttccca tgctcactcc cagggtggtg actctgggaa ggtctcagcc     5880

tccttgtctg cccagttaga atgatctgat gcccctgcta ccatcagact tgataagttt     5940

cccaaagact ctttgcaaga agcactgttc tggagggtgg aggagagact aattgttctt     6000

gctctcctgg ccagagtggg aagctttggg gtggccggtt tgtgggtgca gtggacccca     6060

tcatggagaa gttcaacgcg tccattgcct acgaccggca cctttgggag gtggatgttc     6120

aaggcagcaa agcctacagc aggggcctgg agaaggcagg gctcctcacc aaggccgaga     6180

tggaccagat actccatggc ctagacaagg tacttgccgt ggcccaagcc ccacccaagg     6240

ccccttccct gtggccccag gctcccacca aatccctgag caaacagtgc agtgttgccc     6300

atctgtggtt tcacattgaa ctaattatat actcaagtgc tgtttaactg tgtgccttga     6360

tgactgcctc tctccatcct ttaatgaccc ctgtggccca catggctcat gggtaaaggt     6420

gtgctgggcc tgagatgccc cctcccaggg tgcgcttcca ggactcagct cctgggcagg     6480

gacagtcagt caccagggat agggtgggac caaggcaggg gctctcttgg ctgctgatgc     6540

ctgctcacct gaccccggca ttgctgctac ccactacagg tggctgagga gtgggcccag     6600

ggcaccttca aactgaactc caatgatgag gacatccaca cagccaatga gcgccgcctg     6660

aaggtacgac ccctggagcc ccaccgcttt ccttgcctcc cctctccacc ttgcccaggg     6720

ccactttgag cattagcacc attctgttta cttcgccatt ggcagacagc atgtgagacc     6780

tcaggacatg agccaggcac cctggctcat gcctataatc ctagcacttt gggaggctga     6840

ggtgggagga ttgcttgaga ccaggagttc gagaccagcc tgggcaacat aatgaggtcc     6900

cacagctaca aaaattaaaa aaagaaaaga aaaaaagaac aggcctcagc agaaatggcg     6960

agagatttgg ggaggacccg gagccctggg gtatggaggt aggttggcag ggctgatgag     7020

gaaaactgcc ctgcctgggt tgactcctct gggggtatag accgtgaccc tgggtctccc     7080

ttcacctcca ggagctcatt ggtgcaacgg cagggaagct gcacacggga cggagccgga     7140

atgaccaggt gctttagccc ctccaccccc tgctccgtgt tgtcccaacc ttgaggagcc     7200

cagggggcag ttagagttct gcagcggtcc tggctcctca gggaagcaac acatcggcct     7260

ccctgagcac catctcctcc ttgcacaggt ggtcacagac ctcaggctgt ggatgcggca     7320

gacctgctcc acgctctcgg gcctcctctg ggagctcatt aggaccatgg tggatcgggc     7380

agaggcgtga gtcctacagg gacacccagg gggcagacag aggtgtgatg gaagcctgaa     7440

caggagacct agggggcagg ggtgaacagc gtgggggtgc caggccctgg gggacagggg     7500

catcccagaa ctccaggatc gaggcagagc agccaggagt gggccatttc ctgcaggccc     7560

caatactccc atgccagtct agctcagcag gcagagaaga ctaacccttc gtggggctgg     7620

gtgcggtggc tcacgcctgt aatctcagca ctttgggagg ccgaggtggg tggatcacct     7680

gaggtcagga gttcgagacc agcctggcca acatgggaaa actctgtctc tactaaaaat     7740

acaaaaatta ggcaatgtgg tggtgtgcgc ctgtaatccc agctactcgg gagcctgagg     7800

cagaagaact gcttgaaccc gggaggagga ggttgcaatg agccgagatc gcgccattgc     7860

actccagcct gggctacaga gcgagactcc tgtctcaaaa aaaaagaaaa aaaaaaaaga     7920

aaactcacca tttgcagatt tgaaggcagg aagctaagcc aagcacagct agcttggctg     7980

tgcctggagc agccagagtc actccccaca ctgcctgtcc cccagatccc ccatcctaag     8040

cttcgcctcc ccatccagcc catctggcaa aagacagagc caaaggctgc ctcctgctgg     8100

cctcatttca ggctttggct tctgggacct ggtgtctttg ggactggatt tgttccttgc     8160

agacctggac gaagagctgc tgagaagtct ccatgtgttg tcagagaccc ctcctcttcc     8220

tcaactccct gtgacccctg ttgtgcagac ttgggggaaa acaagggcac aagaattgtc     8280

acccagcagg tggtgtgggg ctgctaggag gaacagggag tgtctgctac tgagttcagg     8340

gtttctttaa ttttttgttg ttgttgtttg ttgttgtttt tttttttttg agacagggtt     8400

ttgctctgtc acctagtctg gagtgtagtg gcgctatctg agctaactgc aaactctgcc     8460

tcctgggttc aagtgattct agtgcctcag cctcccaagt agctgagatt acaggtgtgc     8520

accaccatgt ccagctaatt tttgtatttt tttcagtaga gatgggtttt gccatgttga     8580

ccaggctggt cttgaactcc tgagctcagg tgatctgccc gcgtcggcct gccaaagtgc     8640

taggattaca cccataagcc actgcgctca gcttaatttt taaattttta actttttaaa     8700

ttgtctttag agatgagatc ctgctctgtc acctaggctg gagtgcaatg gcttggtaat     8760

agctcactgc agtctcaaac tcctggactc aaatgatcct cccacctcag ctttctgagt     8820

agctaggacc acaggtgtgc accacctgtg agacagagtc ttgctctgtt gcccaggctg     8880

gagtgcagtg gcgtgatctc cactcactgc aacctctgcc tcccaggttc acgccattct     8940

cctgcctcag cctcccgagt agctgggagt acaggtgccc accaccacgc ccggctaatt     9000

ttttgtattt ttagtagaga cggggtttca ccatgttagc caggatggtc tcaatctccc     9060

gacctcatga tccacccacc tcggactctc aaagtgctgg gattacaggt gtgagccacc     9120

gtgcccagcc gcgaattctt taaatttttt gtagaaacag ggtctcacta tgtggctcag     9180

gctggtctca aactcccggc cttaagtgat ccttccctct tggcctccca aagtgctggg     9240

attaaagact tgagccaccg tgcctggcct tgagtacaga atttcttcat ggggtgatga     9300

aaatgttcta aaattggttg tggtgatggt tgtacagtaa agtgtaaact ttaaatgagt     9360

aaattgtgaa tgatatctca gtaaagctgg tttatttaaa acaacaggcc aggtgctgtg     9420

gctcacgcct gtaatcccag cactttggaa ggctgaggcg ggtgaatcac ctgaggtcaa     9480

gagttcgaga ccagcctggc caacatggtg aaaccccatc tctactaaaa atacacaaaa     9540

ttagctgggt gtgatggtgg gcacctgtag tcccagctac ttgggaggca ggagaatctc     9600

ttggacctgg gaggtggagg ttgtagtgag ccgagatcac gccactgcat tccagcctgg     9660

gcaacaagag cgaaactctt tctcaaaaac aacaacaaca aaaaaacagg ccaggtatgg     9720

tggctcatat ctgtaatccc agccctttgg gaggccaagg caggaggact gcctgaaacc     9780

aggagtttca gaccactctg ggcaacatag caagacccca tctttttttt tttttttgag     9840

acggagtctc gctctgtcgc ccaggctgaa gtgcaatggt gcaatctcaa ctcactgcaa     9900

gctctgcctc ctgggttcat gccattctcc tgcctcagcc ctcctgagta gctggaacta     9960

caggcgccca ccactacgcc cggctaattt tttgtatttt tagtatagat ggggtttcac    10020

cgtgttagcc aggatggtct cgatctcctg accttgtgat ctgcccgcct cggcctccca    10080

aagtgctggg attacaggcg tgagttaccg cgcctggcca caagacccca tctttacaaa    10140

aaactaaaaa ttagctgggc atggtggcat gtccctttag tcccagctac tcaggaggct    10200

gagacaggag gatcgcttga gcccaggaga tcgaggcagc agtgagctat gatcatgcca    10260

ctgcactcca gtctgggcaa cagaacgaga ccttgtctct aaaaataaaa acaaaacaaa    10320

acaacaagaa aacaggacca tcactcacag cacctctgcc tctgccctgc ctacttgaat    10380

gaggtgcagg gcatctcacc tgctcagagc agcccttgaa tgagccccag ctatttctag    10440

ggtcctcaaa cgaaacctcc cacggccaag tcatacccaa catgggcctc ctcccctatt    10500

ctggcccctg ctcggagatg ctgagtgaca gaggctggac ttggggtgtt tctggcaaag    10560

cctcactgca ggaagcccca cagctcaggc ccagtccttg gttcacacgg tcccacttcc    10620

agcttctttt gcccttaaga ctgatttgtc cctgggagat caccagatcc ctcattcagg    10680

tggagtgctg cagcgtgaca ctttttccag gggtgaccca ggcctgcagg gttccagtgt    10740

cacaggcagg ccttgcatga gcctccaccc gagcttctgc tcctcctctc ccacagggaa    10800

cgtgatgttc tcttcccggg gtacacccat ttgcagaggg cccagcccat ccgctggagc    10860

cactggattc tgaggtgagc caggtgaggt gcaggggctg tgctagaggg gaggaccccg    10920

gctgccctga ccctcctgcc cctggcttcc cacagccacg ccgtggcact gacccgagac    10980

tctgagcggc tgctggaggt gcggaagcgg atcaatgtcc tgcccctggg gaggtgggtg    11040

aggctccagt gccccgaggg cctggtgggg gtggctgctg catagcctta gggattgaca    11100

gagctgggaa gtgcagagtg ggacagaaaa ccgccttatc tgctcagcgg gggactctgc    11160

atggagcccc agctctcgct aaggtgacga ccaagccatt gaatgtgtct gagcagggcc    11220

agagccctcc agcaaggctc ctggcaagcc cagcctgctg ccctcagcct gacatgtggg    11280

aacatgtgtc aggagacaag tgtcctgcac ccagggtgac ttagtgcttg gggacaagtg    11340

ttttgtggac acttggggac aagtattctg tacccaagga gactgggcca gggaagaggc    11400

taagcgccag gtggttgccc tggcaaccag gacttggttc tctgtgtgtg cgttcgtgtg    11460

tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtcaggg ctgcctgcca ggagccctgg    11520

tcaccatgaa tccctgtccc tgcagtgggg ccattgcagg caatcccctg ggtgtggacc    11580

gagagctgct ccgagcaggt gagacgtcct gcccctcctc cccagggaga atcaccctca    11640

gcacccgcca agacctgcag acacacctga aaccagaggg caggggcctg tggctcctgg    11700

tgaaaccttc attcattgcc tatgggcact gaggtcatca agttcagggg tcactcatgg    11760

cagggatgcc tggtactgag agactcaggg ctcctgcctc cctcctggga ctgtgcaaaa    11820

gatccctccc cccagctgtt gccccaccct gatcagggga gggggctggg caacctagtt    11880

gggggagagg gggccactcc ctgtcctcca gcttagccct gcttcctccc acccccccag    11940

aactcaactt tggggccatc actctcaaca gcatggatgc cactagtgag cgggactttg    12000

tgggtgagtc ctggggagcc agtcccctgc cctgtgcctc actttagtcc ttcagcccag    12060

cttctctcca gtttcctccc acacctccac ggacaggctg gttgtggtga tattgtacac    12120

tgaagtataa accttaaatg ggtaaagtgg gtggggcatg gtggttcacc atgcccagca    12180

ctggccaaca tggtgaaacc ccatctctac taagaataca aaatttagct gggtgtgtgg    12240

tggcaggtgc ctgtaatccc agctactcag gagttctgag gccagagaat cacttgaacc    12300

caggaggcgg aggctgcagt gagccaagat cacgccagtg cactccagcc tgggcaacaa    12360

gagcgaaact ccatctcaaa aaataaaata aaataaaata aaaataaata ggccaggcat    12420

ggtggctcac gcccgtaatc ctagcacttt gggagtccga ggcaggtgga tcacatgagg    12480

tcaggagttt aagaccagcc tggccaacat ggtgaaaccc catctctact aaaagcacaa    12540

aaattagctg ggcatggtgg tgcatgcctg taatcccagc tactcgggag gctaaggaag    12600

gagattcgct ggaacctggg aggtagaggt tgcagtgagc caagattgtg ccactgtact    12660

ccagcctgtg cattgggagc gagactccat ctcaataaat aaataaataa ataaatggat    12720

aaattgtatg tgagtgataa ctcagtaaag ctggtttatt taaaacaaca acaataacaa    12780

aaaacacgct aggtgcaatg gcttacgttt gtaatcctag cactttggga ggccaaagca    12840

gaaggattgc ttgagcccac aagtttcaga acagcttggg cgacatagca cgaccccatc    12900

tttgcgaaaa atgaaaattt agccgggtcc ccccaccgcc taacctcctc ctgccccctg    12960

tatggtcagg ctgggtgggg atgggagagg cctggtgact gggaaccttt tctcccagcc    13020

gagttcctgt tctgggcttc gctgtgcatg acccatctca gcaggatggc cgaggacctc    13080

atcctctact gcaccaagga attcagcttc gtgcagctct cagatgccta caggtaagcc    13140

ctgaactgcc acctccatct gccgctgccg gcctctgtat cccccgccgc ccgcggacgt    13200

ggctgccttc ctccccgtcc cacccctccg ccagacctgg ccattgcggc gctggaccag    13260

ccaagggtcc agccccttca gcgccagcac ctctgtcccc agcacgggaa gcagcctgat    13320

gccccagaag aaaaaccccg acagtttgga gctgatccgg agcaaggctg ggcgtgtgtt    13380

tgggcgggtg agcaaggcag ggggaggggc ggggcctctg ggctgatggt gggtggccag    13440

gggggcagga tcccgggtcc agcccctgtg cctccctctt cccgcagtgt gccgggctcc    13500

tgatgaccct caagggactt cccagcacct acaacaaaga cttacaggtg cgaggccggg    13560

ggaggcctgg ctagtacgtg ccagttctca gggctctggc acactcaggc agggccccac    13620

cccgggattg ccatacatcc tcccatcctg tgcacacagc tccatccgtg gctgcccttg    13680

aactctctgc ccttcctttg ttggggtatt gagtgttctt cccatggaag gcagtgggga    13740

tgcctcagtg ggggggtggg gctgtgggga ccctgggtgc cagggggctg ctaggccctc    13800

acctcctgcc atgtgcctcc caggaggaca aggaagctgt gtttgaagtg tcagacacta    13860

tgagtgccgt gctccaggtg gccactggcg tcatctctac gctgcaggca agacatcacc    13920

cccctgcttc tcctccccta ggtcccaggc actggggtgg gcatgcgggg agggtggcct    13980

tgggaggagg tgaggtgggg ctggaggacc tggggcaggg aaggagaggt gtgctcgctc    14040

ctgctcctgg ggaacaggga aaggacagaa actgctgcca tgcagtggaa gtagatgaga    14100

ctcagggggc ctggggcctg tcaaatggcc tgaccagaac tctttaaaaa aagaaaatct    14160

aaacaaaagg ccaggtgcag tggctcatgc ctggaatctc acactttggg aggccgaggc    14220

agatggagca cttgaggtca ggggtttgag accagcctgg ccaacatggc gtaaccacgt    14280

ctctactaaa aatacaaaaa ttagccaggc gtgatggccc acacctgtaa tcccagctac    14340

tcaggaggcg gaggcagaag aatagcttga acccaggaga tggaagttgt agtgagccaa    14400

gatcatgccg ctgcactcca gcctggacca cagagtaaaa ctccatctac aaatatataa    14460

attaaattaa attaaattaa atatctttaa aaaacatttt ttagagacag ggtcactctc    14520

tgtcgcccag gctggagtgc agtggtgcgg tcgtagctca ctgcagcctc aaactcttgg    14580

gctcaagtga tcttcccacc tcagtctcca gagtagctgg gactacaaac atgcgccacc    14640

acgcctggct aattttttta ttttttgtag agacagggtc tccctatgtt tcccaggctg    14700

gtctcaaatt cctggcccca agccatcctc ccaccttggt ctcccaaggt gctgggatta    14760

taggcatgag ccactttgcc tggctgattt cttttaaaat caattattat gggaaattta    14820

tgtatataac agctagagaa tgcataatga accctatgta ccgacaccca gcttcaatga    14880

taatcaactc acggacatcc tggctccagc tgtctttacc cacagctctc tcccactccc    14940

ttaccccctt attttgaagc aaattcccat catcacatca tttcattcct aaatagttca    15000

ggatatgtct tgaaatcagt gtttcttggc tgggtgcaga gcctcatgcc tgtaatccca    15060

tcaatttgcg agactaaggt gggcagatca ctcgaggtca ggagttcgag accagcctgg    15120

ccaacatggc gaaaccccgt ctttactaaa aatataaaaa ttagctgggt gtggtggtac    15180

acgcctgtaa tcccagctac tcaggaggct gaggcaggag aattgcttga acccgggaga    15240

tggagactgc agtgagcaga gatcacgcca ctgcgctcca gcctgtgtga cagtgcaaga    15300

ctccatctca aaaaaaaaaa aaaaaaaaaa aggcagtgtt tctggaggct agtcccccaa    15360

ctagcagcac cagcatcacc tcagaagtcc tgagaaatgt gatgtgaggc cccactccag    15420

atggctgaat cagagactct gggggtgctc cccagcaatt tgtatttttc ttagtaaatt    15480

ctccagtggc taggcctggt ggctcatgct tgtaatccca gcactttgag aagctgaggc    15540

aggagaagcg cttgagccca ggagttcaaa accagcctga gcaacatagc gagaccttgt    15600

ctgtaaaatt aaaaaaatta aattagccag tcgtgatggc gtgtacctgt ggtcccagcc    15660

acttaggaga ctgatgtggg aggatccctt gagcccagga gctcaaggat gcagagagcc    15720

aggattgtgc cattgcactc caacatgggc gaccctgtct caaaaaagcc caaaacaaca    15780

acaacaaatt agctaggcac ggtggtgtgc atggctgtag tcccagctac ttgggaggct    15840

gaggctggaa gatcccttga gtccaggctg cagagggcta taatggccac tgcactccag    15900

cctggacaac agagcaagac cctgtctcct aaaacagaaa acaaatcctc caggaacatc    15960

tgatgcatgc tgaagataag gactctttga aaacataaag gccagtaaaa catacaggcc    16020

agtaagtgtt catagcacat gtaaatatta tcgataatta tgagaagatg gttcaagttg    16080

agagtgagac agagccgagt gggtaagaga gtatctgccc aaggcaggga tgtcctggca    16140

gaggggcagg tcctgggcct ggcagcttca gatcccaggg tccccagggc tcaccactcg    16200

cccacctgtg cccccagatt caccaagaga acatgggaca ggctctcagc cccgacatgc    16260

tggccactga ccttgcctat tacctggtcc gcaaaggggt aagtgtgtag cagccagggg    16320

gagggtgagg agatggggtg ccccccccag agggtggggg agctcaggaa tgggtgcaag    16380

cggcccagcc tggtggctca cccctgtaat cccagcactt tgggaagccg aggtgggcgg    16440

gtcacttgag gccaggagtt cgagaccagc ctggtcaaca tggtgaaacc ccgtctcttt    16500

tgatgtaaaa atacaacaat tagctgggtg tggtggcaca ctcctgtaat cccagttact    16560

cgggaggctg aggcaggaga attgattgaa ctgggaggtg gagtttgcgg tgaggtgaga    16620

tcgcgccact gcactccagc ctgggcaaca gagcgagact ttgtgtcaaa aagaaaaaaa    16680

aaaaaaaaag gaagggggtg caggcaatgg aggcagatca gggcatggag aaacctgcct    16740

cagcgccatc ttcctccctg gcacccagat gccattccgc caggcccacg aggcctccgg    16800

gaaagctgtg ttcatggccg agaccaaggg ggtcgccctc aaccagctgt cactgcagga    16860

gctgcagacc atcaggtacg gcccatcccc ttccccatgc tgcctcctag gaagtgagcc    16920

tgggtgcctg gagcccaggg tggcctggcg ccctggccca cctcttcctc tctccccagc    16980

cccctgttct cgggcgacgt gatctgcgtg tgggactacg ggcacagtgt ggagcagtat    17040

ggtgccctgg gcggcactgc gcgctccagc gtcgactggc agatccgcca ggtgcgggcg    17100

ctactgcagg cacagcaggc ctaggtcctc ccacacctgc cccctaataa agtgggcgcg    17160

agaggaggct gctgtgtgtt tcctgcccca gcctggctcc ctcgttgctg ggctttcggg    17220

gctggccagt ggggacagtc agggactgga gaggcagggc agggtggcct gtaatcccag    17280

cactttggaa gggcaaggtg cgaggatgct tgaggccagg agtttgacac agcctgggca    17340

acacagggag acccccatct ctactcaata ataaaacaaa tagcctggcg tggtggccca    17400

tgcatatagt cccagctact tgtaaggctg aggtgagagg acacttgtgc ccaggagtgg    17460

aggctgcagt gagctatgat cacgccactg cattccagcc tggataacag agtgagaacc    17520

tatctctaaa aataaataaa taaacgaaaa ataaa                               17555


<210>  31
<211>  8184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding ODC1

<400>  31
gaagccgggg gcgggggcca cgcgtggggc aggcggtgct cggctcggct gacgtcggcc       60

cgccggcgcc ccaccagctc cgcgcgggcc cgggttggcc accgccgggc ccccgcccct      120

cccccggcgg tgtcccggcc ggaaccgatc gtggctggtt tgagctggtg cgtctccatg      180

gcgacccgcc ggtgctataa gtagggagcg gcgtgccgtg gggctttgtc agtccctcct      240

gtagccgccg ccgccgccgc ccgccgcccc tctgccagca gctccggcgc cacctcgggc      300

cggcgtctcc ggcgggcggg agccaggcgc tgacgggcgc ggcgggggcg gccgagcgct      360

cctgcggctg cgactcaggc tccggcgtct gcgcttcccc atggggctgg cctgcggcgc      420

ctgggcgctc tgaggtgagg gactccccgg ccgcggagga agggagggag cgagggcggg      480

agccggggcg ggctgcgggc cccgggcccc gggcacgtgt gcggcgcgcc tcgccggcct      540

gcggagacac gtggtcgccg agcgggccac gaccttgagg cgccgcttcc tcccggcccg      600

gggttctccc gcggctggat aagggtgatc cgggcgcctc gttctgcccc cgtcttcaca      660

gctcggggct ggaggggcct aggggagacc cacccggaga ccctgcggcc ccgcgccggc      720

ctctttccca acccttcggc ggccgcgcgc tggccgggga gccgttgggg aggccctggc      780

ggccgcgcag caggtgcagg ggcgcagagc ccgggctcgc cttggtacag acgagcgggc      840

cccggccttg gcgccttcag tttccttcca gtttttattt tcgctgtgtc tacagagcag      900

atgacaccaa tttggaaacc cgcgagagtg ggtagagcta agatagtctt gctgtagtag      960

ctgtgatatt agatgctcgg ccatgactta gaggtgttta tttaaggact gtgaatgact     1020

cggtgatttc ggaaaagctt ggcttagatg aacggacata cacaggggag acagccctaa     1080

ggtttgcaga aaaggctgat tgtgctgttt gcgaagtcga aataattggt gaaagtgtag     1140

aaggcagaac ctctcaggaa tgtctgggga ggacaaagaa tgtgttggct gactttgttt     1200

aaacataaaa ttgggcagac tttaattgat ttgtgaaatt tttttcaaag tttgtttgaa     1260

ttagccccta tctcttctaa cattatcctc ttgtgctaat tgattgacca ttttaaataa     1320

cttagctgtt acagaaagac cgaaaggtgt tcttcagtaa aatatattca agtaagttac     1380

ttaagtaacg ccttaaaaga tacagaaaag caaaaaagta ttggcgtatt aaaaagaaat     1440

caaaactttc caagtttagg cctgaacatt gccttaaaaa tatttaataa ggcctcaaat     1500

gacccagtcc gagactgcat gagcctattt attattaaat tgtaaatatt cttcatataa     1560

acaaaaatat ataaccatgt ctgtaacaaa aatggttttg ctagcgttgt tactctcttc     1620

ccttctccga ggggtgattt aggcaacttc ggaggttgac aatgccaagc agtcacaata     1680

gatagagctt taaagcaaat tctatgcatg ggtttggatt tatgacaggc ccgtcaccct     1740

gggcctgtca tagtacccca tgccagagca aactgtgtcc ccgaaccatt gcctggcctc     1800

tgtgcccgta ggctgctggc actgaagtgg gttgcacagt ggaaaagaag aaagctctac     1860

ctggcagaaa tttttaaagg ttaaaataaa taattttaag aaagctggtt cacaaggtgc     1920

cacatttgat gaaagcaaaa tacagtggct tttattgtta ctagagtgat gttcttgctt     1980

gtttttcttt tttggtgaag ttagccccaa attattctca tagctaagca aatacgagag     2040

tgactgtaag gacagttggc attcccggaa ttgctaaact tggtaggcaa cgctggttta     2100

agaatactga gttctagccg ggcgtggtgg ctcacgcctg taatcccaac actttgggag     2160

gctgaggcag gcggatcacc tgaggtcggg agttggagac cagcctgact aacatggaga     2220

aacgccatct ccactaaaaa tataaaatta gccaggcccc gggtgtggtg gcacatgccg     2280

gtaatcccag ctactcggga gactgaggca ggagaatcgc ttgaacccag gaggcggagg     2340

ttgaggtgag ccgagatcat gccattgcac tccagcctgg gcaacaagag taaaactctg     2400

tctcaaaaaa aaaaaaaaaa aatactgaat tctgatcagg taacagcaac tgtaatacaa     2460

tgtgataagt tgacttgaag attacagttt ttaagaagta tatacccagc taatacatga     2520

aaattaactc gtaaaatctc aaatgctcca gacatttcca tgatgcctgt tggtcagtaa     2580

aaatcattct aagacttagt ggaagtagga aatgtttgta tggctgtgta taaaggctat     2640

aatgtaatcc cagcactttg gaagaccgag gcgggtggat cacctggggt caggagtttg     2700

agacccacct ggacaacgtg gtgaaatcct gtctctacta aaaacacaaa aattagccgg     2760

gcatggtggc aggcgcctgt aatcccagct gctggggagg ctgaggcagg agaatcgctt     2820

gaacccggga ggcagaggtt gcagtgagcc aagattgcac cgctgcactc cagcctgggt     2880

gacagcgtga gactctgtct caaaaaaaat aaaaaagtct ataatgctat tttaagtttc     2940

taaggaactg aaactgctct gaaataaatc agaccattat aagacttttt tccatatcag     3000

tgagctaagt gcagataagc ttctgaaact tgcatgctag atttttttgg tacaaatatt     3060

tgaaatgctt agtgtgctgc cttggaaaaa cctggtattt tttgttgtgt ccttatactg     3120

ccaaggttta tggaatcatg taccttatgc ctagtaataa ttaggatgac caggccagtg     3180

agtggttcat atccggggca tgattagctc tgcgtgtgct cagccagtgc cccatcttca     3240

actcgatgtg ttcctaaggt agacagcaaa ttccctattt tatttctcag attgtcactg     3300

ctgttccaag ggcacacgca gagggatttg gaattcctgg agagttgcct ttgtgagaag     3360

ctggaaatat ttctttcaat tccatctctt agttttccat gtaagtattc agtttacatt     3420

tatgttgcag gttaatctta agaattgtat tgctaaggct tctaagtgaa tttctccact     3480

ctatttgcat tttgttgcat ttcagaggaa catcaagaaa tcatgaacaa ctttggtaat     3540

gaagagtttg actgccactt cctcgatgaa ggttttactg ccaaggacat tctggaccag     3600

aaaattaatg aagtttcttc ttctgtaagt atatgaggcc catgctggca gtgcagctga     3660

gagtgccagg caagtggaaa actttggcaa ggtctaagga agagcaatga ggcttacatg     3720

tcttgttatg gaatgtagaa attaattcac tggtggtaaa ttaatagtga taatggtgat     3780

actcatatca gtggctagac tcaaaagagc aggattcatt gtgactgatg ggaatgaagg     3840

tcgctggcta ttggtgtggt gtgtggtgag gctgctagtg agtcacctgt gaccactctt     3900

gtttcaggat gataaggatg ccttctatgt ggcagacctg ggagacattc taaagaaaca     3960

tctgaggtgg ttaaaagctc tccctcgtgt cacccccttt tatgcagtca aatgtaatga     4020

tagcaaagcc atcgtgaaga cccttgctgc taccgggaca ggatttgact gtgctagcaa     4080

ggtaagcgat agcagcaggc ctcaaaagcg ttgtataaaa tgggcctggt attccccacg     4140

aggcagatac aagttgtgtt ttttgggcaa taaatgctca ctaaaggcaa atggggcggg     4200

ggggtacatg acaacttccc atgcttttct gtttattcca cgtgttaagc cacatatgga     4260

tagcatgaca ccactcttct ttttcagact gaaatacagt tggtgcagag tctgggggtg     4320

cctccagaga ggattatcta tgcaaatcct tgtaaacaag tatctcaaat taagtatgct     4380

gctaataatg gagtccagat gatgactttt gatagtgaag ttgagttgat gaaagttgcc     4440

agagcacatc ccaaagcaaa gtgagttatt cccccatctg agggcaagat cgggagcata     4500

agatatgtgg attcttatca aacaaactta aatttctgat tattatattt ctatacttta     4560

gtagaaagta gttgaaaccc ccattgagtc atgaagcctg ggactcaaac tacagaatat     4620

atcagcgaca gtatttagaa caggattgtt tttattttaa ttgtggctat aagtgaacat     4680

ctatcatgag acatttgctg cactttcctt gcttgtaggt tggttttgcg gattgccact     4740

gatgattcca aagcagtctg tcgtctcagt gtgaaattcg gtgccacgct cagaaccagc     4800

aggctccttt tggaacgggc gaaagagcta aatatcgatg ttgttggtgt caggtgagat     4860

tttggtggga tagctagagg tcaagacatt gaacagtttg agttttacag gctttctcct     4920

agtgtttgct attattttaa gaaatactaa gacacagtgt ctcgtctctt tattttaccc     4980

cagcttccat gtaggaagcg gctgtaccga tcctgagacc ttcgtgcagg caatctctga     5040

tgcccgctgt gtttttgaca tgggggtgag tatacgtgac cctgttaggg aagggcggga     5100

cacaactgac aataactagt cttaattcta gagttaactt tttatggcag ttggttctgt     5160

attacatggg tttcagccta tctgctgcat acatttttgt tattagctgt ggatctggct     5220

gacttatttt cttgattcta ggctgaggtt ggtttcagca tgtatctgct tgatattggc     5280

ggtggctttc ctggatctga ggatgtgaaa cttaaatttg aagaggtaat ttagaacaaa     5340

actgtaatac tcagtagccg ttctaataaa ttcctttttg gaatatttca aaatttaagt     5400

gtcttaacta ataccacaat gggctgaagt gtcttggtgt gatattttga gtgatttctt     5460

tgtgctgtct gacattacac ttgataccat ttggttttct aaagtgtgaa tcagctttcc     5520

cagaagtctt ggataattgg ttacattgga aatcatggct cacacctgta atccagcact     5580

tggggaggcc aaggtggtag gatcacttga gcccaggagt ttgagaccag cctgggcaac     5640

acagtgagac cccatctcta caaaaaaaat tttaaaatta gcctggtgtg gtggcgggca     5700

cctgtaatcc cagctacttg gaaggctgag gtgggaggat cacttgagcc caggaggttg     5760

aggctgcagt gagccatgat catgccactg cactcagcct gggctacaga gtgagaccct     5820

gtctcaaaaa aaaaaaagaa aaagcatgtt gctgtgggct tcctagagaa tatgctgact     5880

gtagcacatc atcaccccaa atgtgctttg ctagacctat gcttcctctc cttaaaatac     5940

ttgaaatgtt tagtcactta ggaagttaag ccattatatt ggtgcttgaa tttataaaat     6000

atatccacat ggtttgttaa aatcatgacg taggcagaat aggattttta tcctgttggc     6060

atgtatttgt taaaatgttt tgacatcttg atgccttcct aggtagtagt tagttgcgta     6120

ctgttctttg ataaaaatca tacccataac atcctaaagg agatagggtg cctggagggg     6180

aatgaaaacg agccacctgg gatatgtagc ctggttttca gggagatgtt gatgtttttt     6240

tgcttttgtt actttaatga taaacctgtc tgttgatgcc tggtctcatg atgtcatgtc     6300

acaaggccct gtgatgttac tcccccatgt gaatttccca caatgaaggc tgctctttct     6360

tttctgtttc actctcttag atcaccggcg taatcaaccc agcgttggac aaatactttc     6420

cgtcagactc tggagtgaga atcatagctg agcccggcag atactatgtt gcatcagctt     6480

tcacgcttgc agttaatatc attgccaaga aaattgtatt aaaggaacag acgggctctg     6540

atggtatgta taaaggacga atcacttcat gtataactga aagctgatgc aaaaagtcat     6600

taagattgtt gatctgcctt tctagacgaa gatgagtcga gtgagcagac ctttatgtat     6660

tatgtgaatg atggcgtcta tggatcattt aattgcatac tctatgacca cgcacatgta     6720

aagccccttc tgcaaaaggt aatttctgag catactgtat aaaacaatta agaggactgg     6780

tcacaacacg tgtaattaag tagtacttcc tctctccgtc tctttatata gagacctaaa     6840

ccagatgaga agtattattc atccagcata tggggaccaa catgtgatgg cctcgatcgg     6900

attgttgagc gctgtgacct gcctgaaatg catgtgggtg attggatgct ctttgaaaac     6960

atgggcgctt acactgttgc tgctgcctct acgttcaatg gcttccagag gccgacgatc     7020

tactatgtga tgtcagggcc tgcgtggtaa gtaagccatg catgttgatg gtgctgccaa     7080

gaataggcac cttcttggat gtgtgcttct tgtctagacg aataagaaat tgtcttgcct     7140

aagattaaat atatatggat atttttccta agaaaagttt tagaaaagac tgatgagtgt     7200

atttctatgt aattggaata tatttaagtt catgccatgt gtcttgtggt ttccttatta     7260

ccaaaacggt gactgaagaa acgcttgctt tagaaataca ttgaattggc caggtgtgct     7320

ggctcacacc tgaaatcaca acacattggg aggccaaggc agaaggatca cttgagccca     7380

ggagttcgag cctgggcaac atagtgagac cctgtctcta caaaaaatta aaaaattagt     7440

tggccatggt agtgggcgcc tgtagtccca gctgcttggc taaggtgaga ggtttgcttg     7500

agcctgggag gttgaggctg cggtgagcta tgatagcacc attgtattcc agcctgagta     7560

acagagaaag accctgtctc agaaaaaaaa aaaatacatt gaattgtttc ctgatgggaa     7620

gtaaatactc tcatgcccag ttaggagtga gtcagggttt ttaatatgcc actttttctt     7680

tctcaggcaa ctcatgcagc aattccagaa ccccgacttc ccacccgaag tagaggaaca     7740

ggatgccagc accctgcctg tgtcttgtgc ctgggagagt gggatgaaac gccacagagc     7800

agcctgtgct tcggctagta ttaatgtgta gatagcactc tggtagctgt taactgcaag     7860

tttagcttga attaagggat ttggggggac catgtaactt aattactgct agttttgaaa     7920

tgtctttgta agagtagggt cgccatgatg cagccatatg gaagactagg atatgggtca     7980

cacttatctg tgttcctatg gaaactattt gaatatttgt tttatatgga tttttattca     8040

ctcttcagac acgctactca agagtgcccc tcagctgctg aacaagcatt tgtagcttgt     8100

acaatggcag aatgggccaa aagcttagtg ttgtgacctg tttttaaaat aaagtatctt     8160

gaaataatta ggcattggga cgtt                                            8184


<210>  32
<211>  1344
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding ArgG

<400>  32
atgacgacga ttctcaagca tctcccggta ggtcaacgta ttggtatcgc tttttctggc       60

ggtctggaca ccagtgccgc actgctgtgg atgcgacaaa agggagcggt tccttatgca      120

tatactgcaa acctgggcca gccagacgaa gaggattatg atgcgatccc tcgtcgtgcc      180

atggaatacg gcgcggagaa cgcacgtctg atcgactgcc gcaaacaact ggtggccgaa      240

ggtattgccg ctattcagtg tggcgcattt cataacacca ccggcggcct gacctatttc      300

aacacgacgc cgctgggccg cgccgtgact ggtaccatgc tggttgctgc gatgaaagaa      360

gatggcgtga atatctgggg tgacggtagc acctacaaag gaaacgatat cgaacgtttc      420

tatcgttatg gtctgctgac caatgctgaa ctgcagattt acaaaccgtg gcttgatact      480

gactttattg atgaactggg cggccgtcat gagatgtctg aatttatgat tgcctgcggt      540

ttcgactaca aaatgtctgt cgaaaaagcc tactccacag actccaacat gcttggtgca      600

acgcatgaag cgaaggatct ggaatacctc aactccagcg tcaaaatcgt caacccgatt      660

atgggcgtga aattctggga tgagagcgtg aagatcccgg cagaagaagt cacagtacgc      720

tttgaacaag gtcatccggt ggcgctgaac ggtaaaacct ttagcgacga cgtagaaatg      780

atgctggaag ctaaccgcat cggcggtcgt cacggcctgg gcatgagcga ccagattgaa      840

aaccgtatca tcgaagcgaa aagccgtggt atttacgaag ctccggggat ggcactgctg      900

cacattgcgt atgaacgcct gttgaccggt attcacaacg aagacaccat tgagcagtat      960

cacgcgcatg gtcgtcagtt gggccgtctg ctgtaccagg ggcgttggtt tgactcccag     1020

gcgctgatgc tgcgtgactc tctgcaacgc tgggttgcca gccagatcac tggtgaagtt     1080

accctggagc tgcgccgtgg gaacgattat tcaatcctga ataccgtctc agagaacctg     1140

acctacaagc cagagcgtct gacgatggaa aaaggcgact cggtgttctc gccagatgat     1200

cgtattggtc aattgaccat gcgtaacctg gatatcactg atacccgcga gaaacttttc     1260

ggttatgcca aaactggcct gctttcctcc tctgccgctt caggcgtgcc gcaggtggag     1320

aatctggaaa acaaaggcca gtaa                                            1344


<210>  33
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding ArgH

<400>  33
atggcacttt ggggcgggcg ttttacccag gcagcagatc aacggttcaa acaattcaac       60

gactcactgc gctttgatta ccgtctggcg gagcaggata ttgttggctc tgtggcctgg      120

tccaaagccc tggtcacggt aggcgtgtta accgcagaag agcaggcgca actggaagag      180

gcgctgaacg tgttgctgga agatgttcgc gccaggccac aacaaatcct tgaaagcgac      240

gccgaagata tccatagctg ggtggaaggc aaactgatcg acaaagtggg ccagttaggc      300

aaaaagctgc ataccgggcg tagccgtaat gatcaggtag cgactgacct gaaactgtgg      360

tgcaaagata ccgttagcga gttactgacg gctaaccggc agctgcaatc ggcgctggtg      420

gaaaccgcac aaaacaatca ggacgcggta atgccaggtt acactcacct gcaacgcgcc      480

cagccggtga cgttcgcgca ctggtgcctg gcctatgttg agatgctggc gcgtgatgaa      540

agccgtttgc aggatgcgct taagcgtctg gatgtcagcc cgctaggctg tggcgcgctg      600

gcgggaacgg cctatgaaat cgaccgtgaa cagttagcag gctggctggg ctttgcttcg      660

gcgacccgta acagtctcga cagcgtttct gaccgtgacc atgtgttgga actgctttct      720

gctgccgcta tcggcatggt gcatctgtcg cgttttgctg aagatctgat tttctttaac      780

accggcgaag cggggtttgt ggagctttct gaccgcgtga cttccggttc atcattaatg      840

ccgcagaaga aaaacccgga tgcgctggag ctgattcgcg gtaaatgcgg ccgggtgcag      900

ggggcgttaa ccggcatgat gatgacgctg aaaggtttgc cgctggctta caacaaagat      960

atgcaggaag acaaagaagg tctgttcgac gcgctcgata cctggctgga ctgcctgcat     1020

atggcggcgc tggtgctgga cggcattcag gtgaaacgtc cacgttgcca ggaagcggct     1080

cagcagggtt acgccaacgc caccgaactg gcggattatc tggtggcgaa aggcgtaccg     1140

ttccgcgagg cgcaccatat tgttggtgaa gcggtggtgg aagccattcg tcagggcaaa     1200

ccgctggaag atctgccgct cagtgagttg cagaaattca gtcaggtgat tgacgaagat     1260

gtctatccga ttctgtcgct gcaatcgtgc ctcgacaagc gtgcggcaaa aggcggcgtc     1320

tcaccgcagc aggtggcgca ggcgattgct tttgcgcagg ctcggttagg gtaa           1374


<210>  34
<211>  1005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding ArgF

<400>  34
atgtccgatt tatacaaaaa acactttctg aaactgctcg actttacccc tgcacagttc       60

acttctctgc tgacccttgc cgcacagctc aaagccgata aaaaaaatgg caaggaagta      120

cagaagctta ccggtaaaaa catcgcgctc atcttcgaaa aagactcgac tcgtacccgt      180

tgctctttcg aagttgccgc atttgaccag ggcgcgcgcg ttacctattt agggccgagc      240

ggcagccaga ttgggcataa agagtcaatt aaggacaccg cgcgggttct cgggcggatg      300

tatgacggca ttcagtatcg cggtcacggc caggaagtgg tcgaaacgct ggcgcagtat      360

gcgggcgtgc cggtgtggaa cgggctgacc aacgagttcc acccgaccca gctgctggcg      420

gacctgatga ccatgcagga gcacctgccg ggcaaggcgt ttaacgagat gacgctggtc      480

tacgcgggcg atgcgcgcaa caacatgggc aactcgatgc tggaagcggc ggcgctgacc      540

gggctggatc tgcgcctgtt ggccccgaaa gcctgctggc cggaagagag cctggtggcg      600

gagtgcagcg cgctggcgga gaagcacggc gggaaaatta ctctgacgga agacgtggcg      660

gcaggcgtta agggcgcgga ctttatctat accgacgtgt gggtgtcgat gggcgaggcc      720

aaagagaagt gggcagagcg gattgcgctg ctgcgcgggt atcaggtgaa cgcgcagatg      780

atggcgctga ccgacaaccc gaacgtgaag ttcctgcact gtctgccggc gttccatgac      840

gaccagacta cgctcggcaa gcagatggcg aaggagttcg atctgcacgg cgggatggag      900

gtgacggacg aggtgtttga gtcggcggcg agcatcgtgt tcgaccaggc ggaaaaccgg      960

atgcatacga ttaaggcggt gatgatggca acgcttgggg agtga                     1005


<210>  35
<211>  2124
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding Trp5

<400>  35
atgtcagaac aactcagaca aacatttgct aacgctaaaa aagaaaacag gaacgccttg       60

gtcacattta tgaccgcagg ttacccaaca gtcaaagaca ctgtccctat tctcaagggt      120

ttccaggatg gtggtgtaga tatcatcgaa ttgggtatgc ccttctctga tccaattgca      180

gatggtccta caattcaatt atctaatact gtggctttgc aaaacggtgt taccttgcct      240

caaactctag aaatggtctc ccaagctaga aatgaaggtg ttaccgtacc cataatccta      300

atgggttact ataaccctat tctaaactac ggtgaagaaa gatttattca ggacgctgcc      360

aaggctggtg ctaatggttt tatcatcgtc gatttgccac cagaggaggc gttgaaggtc      420

agaaactaca tcaatgataa tggtttgagc ctgatcccac tagtggctcc ttctaccacc      480

gacgaaagat tggaattact atcgcatatt gccgattcgt ttgtctacgt tgtgtctaga      540

atgggtacta ctggtgttca aagttctgtg gccagtgatt tggatgaact catctctaga      600

gtcagaaagt acaccaagga tactcctttg gccgttgggt ttggtgtctc taccagagaa      660

catttccaat cagttggtag tgttgctgac ggtgtagtga ttggttccaa aatcgtcaca      720

ttatgtggag atgctccaga gggcaaaagg tacgacgttg ctaaggaata tgtacaggga      780

attctaaatg gtgctaagca taaggttctg tccaaggacg aattctttgc ctttcaaaaa      840

gagtccttga agtccgcaaa cgttaagaag gaaatactgg acgaatttga tgaaaatcac      900

aagcacccaa ttagatttgg ggactttggt ggtcagtatg tcccagaagc tcttcatgca      960

tgtctaagag agttggaaaa gggttttgat gaagctgtcg ccgatcccac attctgggaa     1020

gacttcaaat ccttgtattc ttatattggc cgtccttctt cactacacaa agctgagaga     1080

ttaactgagc attgtcaagg tgctcaaatc tggttgaaga gagaagatct taaccacacg     1140

ggatctcaca agatcaacaa tgctttagca caagttcttc tagctaaaag attaggcaag     1200

aagaacgtta ttgctgaaac cggtgctggt caacacggtg ttgccactgc cactgcatgt     1260

gctaaatttg gcttaacctg tactgtgttc atgggtgcag aagatgttcg tcgccaagct     1320

ttaaacgtct tcagaatgag aattctcggt gctaaagtaa ttgctgttac taatggtaca     1380

aagactctaa gagacgctac ttcagaggca ttcagatttt gggttactaa cttgaaaact     1440

acttactacg tcgtcggttc tgccattggt cctcacccat atccaacttt ggttagaact     1500

ttccaaagtg tcattggtaa agaaaccaag gaacagtttg ctgccatgaa caatggtaaa     1560

ttacctgacg cagttgttgc atgtgttggg ggtggttcca actctacagg tatgttttca     1620

ccattcgagc atgatacttc cgttaagtta ttgggtgtgg aagccggtgg tgatggtgta     1680

gatacaaagt tccactctgc tactctaact gccggtagac ctggtgtctt ccatggtgtc     1740

aagacttatg tcttgcaaga tagtgatggt caagtccatg atactcattc tgtttctgct     1800

gggttagact acccaggtgt cggtccagaa ttggcatatt ggaaatctac tggccgtgct     1860

caattcattg cagctactga cgctcaggct ctgcttggct ttaaattatt atctcaatta     1920

gaaggtatta ttcccgcttt ggaatcttct catgctgttt atggcgcttg cgaattggct     1980

aagacgatga agcctgatca acatttggtt atcaatattt ctggtagagg tgataaagat     2040

gtccaaagtg tcgctgaagt cttgccgaaa ttaggtccaa agataggttg ggatttgaga     2100

ttcgaagaag acccatctgc ctaa                                            2124


<210>  36
<211>  2124
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding IDO

<400>  36
atgtcagaac aactcagaca aacatttgct aacgctaaaa aagaaaacag gaacgccttg       60

gtcacattta tgaccgcagg ttacccaaca gtcaaagaca ctgtccctat tctcaagggt      120

ttccaggatg gtggtgtaga tatcatcgaa ttgggtatgc ccttctctga tccaattgca      180

gatggtccta caattcaatt atctaatact gtggctttgc aaaacggtgt taccttgcct      240

caaactctag aaatggtctc ccaagctaga aatgaaggtg ttaccgtacc cataatccta      300

atgggttact ataaccctat tctaaactac ggtgaagaaa gatttattca ggacgctgcc      360

aaggctggtg ctaatggttt tatcatcgtc gatttgccac cagaggaggc gttgaaggtc      420

agaaactaca tcaatgataa tggtttgagc ctgatcccac tagtggctcc ttctaccacc      480

gacgaaagat tggaattact atcgcatatt gccgattcgt ttgtctacgt tgtgtctaga      540

atgggtacta ctggtgttca aagttctgtg gccagtgatt tggatgaact catctctaga      600

gtcagaaagt acaccaagga tactcctttg gccgttgggt ttggtgtctc taccagagaa      660

catttccaat cagttggtag tgttgctgac ggtgtagtga ttggttccaa aatcgtcaca      720

ttatgtggag atgctccaga gggcaaaagg tacgacgttg ctaaggaata tgtacaggga      780

attctaaatg gtgctaagca taaggttctg tccaaggacg aattctttgc ctttcaaaaa      840

gagtccttga agtccgcaaa cgttaagaag gaaatactgg acgaatttga tgaaaatcac      900

aagcacccaa ttagatttgg ggactttggt ggtcagtatg tcccagaagc tcttcatgca      960

tgtctaagag agttggaaaa gggttttgat gaagctgtcg ccgatcccac attctgggaa     1020

gacttcaaat ccttgtattc ttatattggc cgtccttctt cactacacaa agctgagaga     1080

ttaactgagc attgtcaagg tgctcaaatc tggttgaaga gagaagatct taaccacacg     1140

ggatctcaca agatcaacaa tgctttagca caagttcttc tagctaaaag attaggcaag     1200

aagaacgtta ttgctgaaac cggtgctggt caacacggtg ttgccactgc cactgcatgt     1260

gctaaatttg gcttaacctg tactgtgttc atgggtgcag aagatgttcg tcgccaagct     1320

ttaaacgtct tcagaatgag aattctcggt gctaaagtaa ttgctgttac taatggtaca     1380

aagactctaa gagacgctac ttcagaggca ttcagatttt gggttactaa cttgaaaact     1440

acttactacg tcgtcggttc tgccattggt cctcacccat atccaacttt ggttagaact     1500

ttccaaagtg tcattggtaa agaaaccaag gaacagtttg ctgccatgaa caatggtaaa     1560

ttacctgacg cagttgttgc atgtgttggg ggtggttcca actctacagg tatgttttca     1620

ccattcgagc atgatacttc cgttaagtta ttgggtgtgg aagccggtgg tgatggtgta     1680

gatacaaagt tccactctgc tactctaact gccggtagac ctggtgtctt ccatggtgtc     1740

aagacttatg tcttgcaaga tagtgatggt caagtccatg atactcattc tgtttctgct     1800

gggttagact acccaggtgt cggtccagaa ttggcatatt ggaaatctac tggccgtgct     1860

caattcattg cagctactga cgctcaggct ctgcttggct ttaaattatt atctcaatta     1920

gaaggtatta ttcccgcttt ggaatcttct catgctgttt atggcgcttg cgaattggct     1980

aagacgatga agcctgatca acatttggtt atcaatattt ctggtagagg tgataaagat     2040

gtccaaagtg tcgctgaagt cttgccgaaa ttaggtccaa agataggttg ggatttgaga     2100

ttcgaagaag acccatctgc ctaa                                            2124


<210>  37
<211>  5691
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding exemplary CAR GD2 ASS1+OTC without MP71 vector

<400>  37
atgcctcgcg gctggacagc cctgtgcctg ctgtctctgc tgccatccgg cttcatgagc       60

ctggataata acggcacagc caccccagag ctgcctacac agggcacctt cagcaatgtg      120

tccacaaacg tgagctatca ggagaccaca accccttcta ccctgggatc cacaagcctg      180

caccccgtgt ctcagcacgg caacgaagcc accaccaaca tcaccgagac cacagtgaag      240

tttacctcca cctctgtgat tacctctgtg tacggaaata caaactccag cgtgcagtct      300

cagacatctg tgatctccac agtgtttaca acacctgcca atgtgtccac cccagagaca      360

accctgaagc ccagcctgtc tcctggaaat gtgtccgatc tgtctaccac ctccaccagc      420

ctggccacct ctcccaccaa gccctatacc tcctcttctc ccatcctgag cgatatcaaa      480

gccgagatca aatgcagcgg gattcgggaa gtgaaactga cacagggcat ctgcctggaa      540

cagaataaga catccagctg cgccgagttt aagaaagata gaggagaggg actggccagg      600

gtgctgtgtg gcgaagagca ggccgacgcc gatgccggcg cccaggtgtg ttccctgctg      660

ctggcccagt ctgaggtgcg cccccagtgc ctgctgctgg tgctggccaa tcggacagaa      720

attagcagca agctgcagct gatgaaaaaa caccagagcg atctgaaaaa gctgggcatc      780

ctggacttta ccgagcagga cgtggcctct caccagagct acagccagaa aacactgatc      840

gccctggtga ccagcggagc cctgctggcc gtgctgggca tcaccggata tttcctgatg      900

aataggcgca gctggagccc caccggcgaa cggctggagc tggagcctgt cgaccgagtg      960

aagcagaccc tgaactttga tctgctgaag ctggccggcg acgtggagtc caaccccggg     1020

ccagggaata tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac     1080

gccgccaggc cggatattct gctcacacag accccactct ccctgcccgt gtcactcggg     1140

gatcaggcta gcatttcttg ccgctcatct cagtctctgg tccaccggaa tgggaacaca     1200

tacctccatt ggtacctcca gaaacctgga cagagcccta aactgctcat ccacaaagtc     1260

tcaaatcggt tctccggcgt gcccgatcgc tttagcggat ccggatctgg gaccgacttc     1320

acactgaaaa tctcacgagt ggaggctgag gatctcggcg tctacttctg tagtcagagt     1380

acccacgtcc cacccctcac ctttggcgct ggaacaaaac tggagctgaa acgagccgat     1440

gctgctccta ccgtgtccat ctttcctggc tccgggggag gcgggagcgg aggcgaagtg     1500

aaactccagc agtctggccc ttctctcgtg gaacctggcg cttctgtgat gatctcctgt     1560

aaggcctctg gatcttcctt taccggctac aacatgaact gggtccggca gaacattggc     1620

aaatccctgg aatggattgg cgccatcgat ccttactacg gcggcacatc atacaatcag     1680

aaattcaagg ggcgagcaac actcactgtc gacaaatctt catccaccgc ctacatgcac     1740

ctgaaatctc tcacatccga ggatagtgct gtctactact gtgtctctgg catggaatac     1800

tggggacagg gaacttctgt caccgtgtct agtgccaaaa ccacacctcc ctccgtgtac     1860

ggacgagtca ctgtctcatc tgctgaacca aaatcctgtg acaaaacaca cacatgccca     1920

ccttgtcctg cccctgaact gctcggcgga ccttccgtct ttctgtttcc ccccaaaccc     1980

aaggatacac tcatgatttc taggaccccc gaagtcactt gtgtcgtggt cgatgtgtct     2040

cacgaggatc ctgaagtgaa attcaactgg tacgtggacg gagtcgaggt ccacaatgcc     2100

aaaacaaaac cccgggagga acagtacaat agcacctacc gagtcgtgtc cgtgctcacc     2160

gtcctccatc aggattggct gaacggcaaa gagtacaagt gtaaagtgag taacaaggct     2220

ctccccgctc ctattgaaaa aaccatctca aaagcaaaag gccagcctag ggagcctcag     2280

gtctacacac tgccaccctc acgggacgaa ctcaccaaaa atcaggtgtc cctcacttgc     2340

ctggtgaaag gcttctaccc ttccgatatc gctgtggaat gggagtcaaa tgggcagccc     2400

gaaaacaact acaaaacaac cccccctgtg ctcgattccg atggctcttt tttcctgtac     2460

tccaaactca ccgtggacaa atcacgctgg cagcagggga atgtcttttc ttgctccgtg     2520

atgcacgagg ccctccacaa tcattacacc cagaaatccc tctcactctc acccggcaaa     2580

aaggacccta aaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     2640

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     2700

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     2760

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     2820

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     2880

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     2940

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     3000

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     3060

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     3120

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     3180

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     3240

atgcaggccc tgccccctcg cggcagcggc gccaccaact tcagcctgct gaagcaggcc     3300

ggcgacgtgg aggaaaaccc tggccccatg tccagcaaag gctccgtggt tctggcctac     3360

agtggcggcc tggacacctc gtgcatcctc gtgtggctga aggaacaagg ctatgacgtc     3420

attgcctatc tggccaacat tggccagaag gaagacttcg aggaagccag gaagaaggca     3480

ctgaaacttg gggccaaaaa ggtgttcatt gaggatgtca gcagggagtt tgtggaggag     3540

ttcatctggc cggccatcca gtccagcgca ctgtatgagg accgctacct cctgggcacc     3600

tctcttgcca ggccctgcat cgcccgcaaa caagtggaaa tcgcccagcg ggagggggcc     3660

aagtatgtgt cccacggcgc cacaggaaag gggaacgatc aggtccggtt tgagctcagc     3720

tgctactcac tggcccccca gataaaggtc attgctccct ggaggatgcc tgaattctac     3780

aaccggttca agggccgcaa tgacctgatg gagtacgcaa agcaacacgg gattcccatc     3840

ccggtcactc ccaagaaccc gtggagcatg gatgagaacc tcatgcacat cagctacgag     3900

gctggaatcc tggagaaccc caagaaccaa gcgcctccag gtctctacac gaagacccag     3960

gacccagcca aagcccccaa cacccctgac attctcgaga tcgagttcaa aaaaggggtc     4020

cctgtgaagg tgaccaacgt caaggatggc accacccacc agacctcctt ggagctcttc     4080

atgtacctga acgaagtcgc gggcaagcat ggcgtgggcc gtattgacat cgtggagaac     4140

cgcttcattg gaatgaagtc ccgaggtatc tacgagaccc cagcaggcac catcctttac     4200

catgctcatt tagacatcga ggccttcacc atggaccggg aagtgcgcaa aatcaaacaa     4260

ggcctgggct tgaaatttgc tgagctggtg tataccggtt tctggcacag ccctgagtgt     4320

gaatttgtcc gccactgcat cgccaagtcc caggagcgag tggaagggaa agtgcaggtg     4380

tccgtcctca agggccaggt gtacatcctc ggccgggagt ccccactgtc tctctacaat     4440

gaggagctgg tgagcatgaa cgtgcagggt gattatgagc caactgatgc caccgggttc     4500

atcaacatca attccctcag gctgaaggaa tatcatcgtc tccagagcaa ggtcactgcc     4560

aaaggaagcg gagagggcag aggaagtctg ctaacatgcg gtgacgtcga ggagaatcct     4620

ggacctatgc tgtttaatct gaggatcctg ttaaacaatg cagcttttag aaatggtcac     4680

aacttcatgg ttcgaaattt tcggtgtgga caaccactac aaaataaagt gcagctgaag     4740

ggccgtgacc ttctcactct aaaaaacttt accggagaag aaattaaata tatgctatgg     4800

ctatcagcag atctgaaatt taggataaaa cagaaaggag agtatttgcc tttattgcaa     4860

gggaagtcct taggcatgat ttttgagaaa agaagtactc gaacaagatt gtctacagaa     4920

acaggcttag cacttctggg aggacatcct tgttttctta ccacacaaga tattcatttg     4980

ggtgtgaatg aaagtctcac ggacacggcc cgtgtattgt ctagcatggc agatgcagta     5040

ttggctcgag tgtataaaca atcagatttg gacaccctgg ctaaagaagc atccatccca     5100

attatcaatg ggctgtcaga tttgtaccat cctatccaga tcctggctga ttacctcacg     5160

ctccaggaac actatagctc tctgaaaggt cttaccctca gctggatcgg ggatgggaac     5220

aatatcctgc actccatcat gatgagcgca gcgaaattcg gaatgcacct tcaggcagct     5280

actccaaagg gttatgagcc ggatgctagt gtaaccaagt tggcagagca gtatgccaaa     5340

gagaatggta ccaagctgtt gctgacaaat gatccattgg aagcagcgca tggaggcaat     5400

gtattaatta cagacacttg gataagcatg ggacaagaag aggagaagaa aaagcggctc     5460

caggctttcc aaggttacca ggttacaatg aagactgcta aagttgctgc ctctgactgg     5520

acatttttac actgcttgcc cagaaagcca gaagaagtgg atgatgaagt cttttattct     5580

cctcgatcac tagtgttccc agaggcagaa aacagaaagt ggacaatcat ggctgtcatg     5640

gtgtccctgc tgacagatta ctcacctcag ctccagaagc ctaaatttta a              5691


<210>  38
<211>  4566
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding exemplary CAR of GD2 ASS1 without MP71 vector

<400>  38
atgcctcgcg gctggacagc cctgtgcctg ctgtctctgc tgccatccgg cttcatgagc       60

ctggataata acggcacagc caccccagag ctgcctacac agggcacctt cagcaatgtg      120

tccacaaacg tgagctatca ggagaccaca accccttcta ccctgggatc cacaagcctg      180

caccccgtgt ctcagcacgg caacgaagcc accaccaaca tcaccgagac cacagtgaag      240

tttacctcca cctctgtgat tacctctgtg tacggaaata caaactccag cgtgcagtct      300

cagacatctg tgatctccac agtgtttaca acacctgcca atgtgtccac cccagagaca      360

accctgaagc ccagcctgtc tcctggaaat gtgtccgatc tgtctaccac ctccaccagc      420

ctggccacct ctcccaccaa gccctatacc tcctcttctc ccatcctgag cgatatcaaa      480

gccgagatca aatgcagcgg gattcgggaa gtgaaactga cacagggcat ctgcctggaa      540

cagaataaga catccagctg cgccgagttt aagaaagata gaggagaggg actggccagg      600

gtgctgtgtg gcgaagagca ggccgacgcc gatgccggcg cccaggtgtg ttccctgctg      660

ctggcccagt ctgaggtgcg cccccagtgc ctgctgctgg tgctggccaa tcggacagaa      720

attagcagca agctgcagct gatgaaaaaa caccagagcg atctgaaaaa gctgggcatc      780

ctggacttta ccgagcagga cgtggcctct caccagagct acagccagaa aacactgatc      840

gccctggtga ccagcggagc cctgctggcc gtgctgggca tcaccggata tttcctgatg      900

aataggcgca gctggagccc caccggcgaa cggctggagc tggagcctgt cgaccgagtg      960

aagcagaccc tgaactttga tctgctgaag ctggccggcg acgtggagtc caaccccggg     1020

ccagggaata tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac     1080

gccgccaggc cggatattct gctcacacag accccactct ccctgcccgt gtcactcggg     1140

gatcaggcta gcatttcttg ccgctcatct cagtctctgg tccaccggaa tgggaacaca     1200

tacctccatt ggtacctcca gaaacctgga cagagcccta aactgctcat ccacaaagtc     1260

tcaaatcggt tctccggcgt gcccgatcgc tttagcggat ccggatctgg gaccgacttc     1320

acactgaaaa tctcacgagt ggaggctgag gatctcggcg tctacttctg tagtcagagt     1380

acccacgtcc cacccctcac ctttggcgct ggaacaaaac tggagctgaa acgagccgat     1440

gctgctccta ccgtgtccat ctttcctggc tccgggggag gcgggagcgg aggcgaagtg     1500

aaactccagc agtctggccc ttctctcgtg gaacctggcg cttctgtgat gatctcctgt     1560

aaggcctctg gatcttcctt taccggctac aacatgaact gggtccggca gaacattggc     1620

aaatccctgg aatggattgg cgccatcgat ccttactacg gcggcacatc atacaatcag     1680

aaattcaagg ggcgagcaac actcactgtc gacaaatctt catccaccgc ctacatgcac     1740

ctgaaatctc tcacatccga ggatagtgct gtctactact gtgtctctgg catggaatac     1800

tggggacagg gaacttctgt caccgtgtct agtgccaaaa ccacacctcc ctccgtgtac     1860

ggacgagtca ctgtctcatc tgctgaacca aaatcctgtg acaaaacaca cacatgccca     1920

ccttgtcctg cccctgaact gctcggcgga ccttccgtct ttctgtttcc ccccaaaccc     1980

aaggatacac tcatgatttc taggaccccc gaagtcactt gtgtcgtggt cgatgtgtct     2040

cacgaggatc ctgaagtgaa attcaactgg tacgtggacg gagtcgaggt ccacaatgcc     2100

aaaacaaaac cccgggagga acagtacaat agcacctacc gagtcgtgtc cgtgctcacc     2160

gtcctccatc aggattggct gaacggcaaa gagtacaagt gtaaagtgag taacaaggct     2220

ctccccgctc ctattgaaaa aaccatctca aaagcaaaag gccagcctag ggagcctcag     2280

gtctacacac tgccaccctc acgggacgaa ctcaccaaaa atcaggtgtc cctcacttgc     2340

ctggtgaaag gcttctaccc ttccgatatc gctgtggaat gggagtcaaa tgggcagccc     2400

gaaaacaact acaaaacaac cccccctgtg ctcgattccg atggctcttt tttcctgtac     2460

tccaaactca ccgtggacaa atcacgctgg cagcagggga atgtcttttc ttgctccgtg     2520

atgcacgagg ccctccacaa tcattacacc cagaaatccc tctcactctc acccggcaaa     2580

aaggacccta aaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     2640

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     2700

acgagggggc tggacttcgc ctgtgatatc tacatctggg cgcccttggc cgggacttgt     2760

ggggtccttc tcctgtcact ggttatcacc ctttactgca aacggggcag aaagaaactc     2820

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc     2880

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgagagt gaagttcagc     2940

aggagcgcag acgcccccgc gtacaagcag ggccagaacc agctctataa cgagctcaat     3000

ctaggacgaa gagaggagta cgatgttttg gacaagagac gtggccggga ccctgagatg     3060

gggggaaagc cgagaaggaa gaaccctcag gaaggcctgt acaatgaact gcagaaagat     3120

aagatggcgg aggcctacag tgagattggg atgaaaggcg agcgccggag gggcaagggg     3180

cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac     3240

atgcaggccc tgccccctcg cggcagcggc gccaccaact tcagcctgct gaagcaggcc     3300

ggcgacgtgg aggaaaaccc tggccccatg tccagcaaag gctccgtggt tctggcctac     3360

agtggcggcc tggacacctc gtgcatcctc gtgtggctga aggaacaagg ctatgacgtc     3420

attgcctatc tggccaacat tggccagaag gaagacttcg aggaagccag gaagaaggca     3480

ctgaaacttg gggccaaaaa ggtgttcatt gaggatgtca gcagggagtt tgtggaggag     3540

ttcatctggc cggccatcca gtccagcgca ctgtatgagg accgctacct cctgggcacc     3600

tctcttgcca ggccctgcat cgcccgcaaa caagtggaaa tcgcccagcg ggagggggcc     3660

aagtatgtgt cccacggcgc cacaggaaag gggaacgatc aggtccggtt tgagctcagc     3720

tgctactcac tggcccccca gataaaggtc attgctccct ggaggatgcc tgaattctac     3780

aaccggttca agggccgcaa tgacctgatg gagtacgcaa agcaacacgg gattcccatc     3840

ccggtcactc ccaagaaccc gtggagcatg gatgagaacc tcatgcacat cagctacgag     3900

gctggaatcc tggagaaccc caagaaccaa gcgcctccag gtctctacac gaagacccag     3960

gacccagcca aagcccccaa cacccctgac attctcgaga tcgagttcaa aaaaggggtc     4020

cctgtgaagg tgaccaacgt caaggatggc accacccacc agacctcctt ggagctcttc     4080

atgtacctga acgaagtcgc gggcaagcat ggcgtgggcc gtattgacat cgtggagaac     4140

cgcttcattg gaatgaagtc ccgaggtatc tacgagaccc cagcaggcac catcctttac     4200

catgctcatt tagacatcga ggccttcacc atggaccggg aagtgcgcaa aatcaaacaa     4260

ggcctgggct tgaaatttgc tgagctggtg tataccggtt tctggcacag ccctgagtgt     4320

gaatttgtcc gccactgcat cgccaagtcc caggagcgag tggaagggaa agtgcaggtg     4380

tccgtcctca agggccaggt gtacatcctc ggccgggagt ccccactgtc tctctacaat     4440

gaggagctgg tgagcatgaa cgtgcagggt gattatgagc caactgatgc caccgggttc     4500

atcaacatca attccctcag gctgaaggaa tatcatcgtc tccagagcaa ggtcactgcc     4560

aaataa                                                                4566


<210>  39
<211>  4398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding exemplary CAR of GD2 OTC without MP71 vector

<400>  39
atgcctcgcg gctggacagc cctgtgcctg ctgtctctgc tgccatccgg cttcatgagc       60

ctggataata acggcacagc caccccagag ctgcctacac agggcacctt cagcaatgtg      120

tccacaaacg tgagctatca ggagaccaca accccttcta ccctgggatc cacaagcctg      180

caccccgtgt ctcagcacgg caacgaagcc accaccaaca tcaccgagac cacagtgaag      240

tttacctcca cctctgtgat tacctctgtg tacggaaata caaactccag cgtgcagtct      300

cagacatctg tgatctccac agtgtttaca acacctgcca atgtgtccac cccagagaca      360

accctgaagc ccagcctgtc tcctggaaat gtgtccgatc tgtctaccac ctccaccagc      420

ctggccacct ctcccaccaa gccctatacc tcctcttctc ccatcctgag cgatatcaaa      480

gccgagatca aatgcagcgg gattcgggaa gtgaaactga cacagggcat ctgcctggaa      540

cagaataaga catccagctg cgccgagttt aagaaagata gaggagaggg actggccagg      600

gtgctgtgtg gcgaagagca ggccgacgcc gatgccggcg cccaggtgtg ttccctgctg      660

ctggcccagt ctgaggtgcg cccccagtgc ctgctgctgg tgctggccaa tcggacagaa      720

attagcagca agctgcagct gatgaaaaaa caccagagcg atctgaaaaa gctgggcatc      780

ctggacttta ccgagcagga cgtggcctct caccagagct acagccagaa aacactgatc      840

gccctggtga ccagcggagc cctgctggcc gtgctgggca tcaccggata tttcctgatg      900

aataggcgca gctggagccc caccggcgaa cggctggagc tggagcctgt cgaccgagtg      960

aagcagaccc tgaactttga tctgctgaag ctggccggcg acgtggagtc caaccccggg     1020

ccagggaata tggccttacc agtgaccgcc ttgctcctgc cgctggcctt gctgctccac     1080

gccgccaggc cggatattct gctcacacag accccactct ccctgcccgt gtcactcggg     1140

gatcaggcta gcatttcttg ccgctcatct cagtctctgg tccaccggaa tgggaacaca     1200

tacctccatt ggtacctcca gaaacctgga cagagcccta aactgctcat ccacaaagtc     1260

tcaaatcggt tctccggcgt gcccgatcgc tttagcggat ccggatctgg gaccgacttc     1320

acactgaaaa tctcacgagt ggaggctgag gatctcggcg tctacttctg tagtcagagt     1380

acccacgtcc cacccctcac ctttggcgct ggaacaaaac tggagctgaa acgagccgat     1440

gctgctccta ccgtgtccat ctttcctggc tccgggggag gcgggagcgg aggcgaagtg     1500

aaactccagc agtctggccc ttctctcgtg gaacctggcg cttctgtgat gatctcctgt     1560

aaggcctctg gatcttcctt taccggctac aacatgaact gggtccggca gaacattggc     1620

aaatccctgg aatggattgg cgccatcgat ccttactacg gcggcacatc atacaatcag     1680

aaattcaagg ggcgagcaac actcactgtc gacaaatctt catccaccgc ctacatgcac     1740

ctgaaatctc tcacatccga ggatagtgct gtctactact gtgtctctgg catggaatac     1800

tggggacagg gaacttctgt caccgtgtct agtgccaaaa ccacacctcc ctccgtgtac     1860

ggacgagtca ctgtctcatc tgctgaacca aaatcctgtg acaaaacaca cacatgccca     1920

ccttgtcctg cccctgaact gctcggcgga ccttccgtct ttctgtttcc ccccaaaccc     1980

aaggatacac tcatgatttc taggaccccc gaagtcactt gtgtcgtggt cgatgtgtct     2040

cacgaggatc ctgaagtgaa attcaactgg tacgtggacg gagtcgaggt ccacaatgcc     2100

aaaacaaaac cccgggagga acagtacaat agcacctacc gagtcgtgtc cgtgctcacc     2160

gtcctccatc aggattggct gaacggcaaa gagtacaagt gtaaagtgag taacaaggct     2220

ctccccgctc ctattgaaaa aaccatctca aaagcaaaag gccagcctag ggagcctcag     2280

gtctacacac tgccaccctc acgggacgaa ctcaccaaaa atcaggtgtc cctcacttgc     2340

ctggtgaaag gcttctaccc ttccgatatc gctgtggaat gggagtcaaa tgggcagccc     2400

gaaaacaact acaaaacaac cccccctgtg ctcgattccg atggctcttt tttcctgtac     2460

tccaaactca ccgtggacaa atcacgctgg cagcagggga atgtcttttc ttgctccgtg     2520

atgcacgagg ccctccacaa tcattacacc cagaaatccc tctcactctc acccggcaaa     2580

aaggacccta aaaccacgac gccagcgccg cgaccaccaa caccggcgcc caccatcgcg     2640

tcgcagcccc tgtccctgcg cccagaggcg tgccggccag cggcgggggg cgcagtgcac     2700

acgagggggc tggacttcgc ctgtgatttt tgggtgctgg tggtggttgg tggagtcctg     2760

gcttgctata gcttgctagt aacagtggcc tttattattt tctgggtgag gagtaagagg     2820

agcaggctcc tgcacagtga ctacatgaac atgactcccc gccgccccgg gcccacccgc     2880

aagcattacc agccctatgc cccacctcgc gacttcgcag cctatcgctc cagagtgaag     2940

ttcagcagga gcgcagacgc ccccgcgtac aagcagggcc agaaccagct ctataacgag     3000

ctcaatctag gacgaagaga ggagtacgat gttttggaca agagacgtgg ccgggaccct     3060

gagatggggg gaaagccgag aaggaagaac cctcaggaag gcctgtacaa tgaactgcag     3120

aaagataaga tggcggaggc ctacagtgag attgggatga aaggcgagcg ccggaggggc     3180

aaggggcacg atggccttta ccagggtctc agtacagcca ccaaggacac ctacgacgcc     3240

cttcacatgc aggccctgcc ccctcgcggc agcggcgcca ccaacttcag cctgctgaag     3300

caggccggcg acgtggagga aaaccctggc cccatgctgt ttaatctgag gatcctgtta     3360

aacaatgcag cttttagaaa tggtcacaac ttcatggttc gaaattttcg gtgtggacaa     3420

ccactacaaa ataaagtgca gctgaagggc cgtgaccttc tcactctaaa aaactttacc     3480

ggagaagaaa ttaaatatat gctatggcta tcagcagatc tgaaatttag gataaaacag     3540

aaaggagagt atttgccttt attgcaaggg aagtccttag gcatgatttt tgagaaaaga     3600

agtactcgaa caagattgtc tacagaaaca ggcttagcac ttctgggagg acatccttgt     3660

tttcttacca cacaagatat tcatttgggt gtgaatgaaa gtctcacgga cacggcccgt     3720

gtattgtcta gcatggcaga tgcagtattg gctcgagtgt ataaacaatc agatttggac     3780

accctggcta aagaagcatc catcccaatt atcaatgggc tgtcagattt gtaccatcct     3840

atccagatcc tggctgatta cctcacgctc caggaacact atagctctct gaaaggtctt     3900

accctcagct ggatcgggga tgggaacaat atcctgcact ccatcatgat gagcgcagcg     3960

aaattcggaa tgcaccttca ggcagctact ccaaagggtt atgagccgga tgctagtgta     4020

accaagttgg cagagcagta tgccaaagag aatggtacca agctgttgct gacaaatgat     4080

ccattggaag cagcgcatgg aggcaatgta ttaattacag acacttggat aagcatggga     4140

caagaagagg agaagaaaaa gcggctccag gctttccaag gttaccaggt tacaatgaag     4200

actgctaaag ttgctgcctc tgactggaca tttttacact gcttgcccag aaagccagaa     4260

gaagtggatg atgaagtctt ttattctcct cgatcactag tgttcccaga ggcagaaaac     4320

agaaagtgga caatcatggc tgtcatggtg tccctgctga cagattactc acctcagctc     4380

cagaagccta aattttaa                                                   4398


<210>  40
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding an alternative CD3z

<400>  40
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgcag agaaggaaga accctcagga aggcctgtac      180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag      240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac      300

acctacgacg cccttcacat gcaggccctg ccccctcgct aa                         342


<210>  41
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  sequence encoding an alternative EGFRvIII target binding moiety 
       (EGFRvIII scFv sequence derived from MR1 antibody)

<400>  41
atggactgga tttggcgcat ccttttcctt gtcggcgctg ctaccggcgc gcattctcag       60

gtacaactcc agcagtctgg gggaggctta gtgaagcctg gagcgtctct gaaactctcc      120

tgtgtaacct ctggattcac tttcagaaaa tttggcatgt cttgggttcg ccagactagt      180

gacaagaggc tggaatgggt cgcatccatt agtactggcg gttataacac gtactattca      240

gacaatgtaa agggccgatt caccatctcc agagagaatg ccaagaacac cctgtacctg      300

caaatgagta gtctgaagtc tgaggacacg gccttgtatt actgtacaag aggctattct      360

agtacctctt atgctatgga ctactggggc caagggacca cggtcaccgt ctcctcaagt      420

ggaggcggtt caggcggagg tggctctggc ggtggcggat cggacatcga gctcactcag      480

tctccagcat ccctgtccgt ggctacagga gaaaaagtca ctatcagatg catgaccagc      540

actgatattg atgatgatat gaactggtac cagcagaagc caggggaacc ccctaagttc      600

cttatttcag aaggcaatac tcttcggccg ggagtcccat cccgattttc cagcagtggc      660

actggcacag attttgtttt tacaattgaa aacacactct cggaagatgt tggagattac      720

tactgtttgc aaagctttaa cgtgcctctt acattcggtg atggcaccaa gcttgaaaaa      780

gctcta                                                                 786


<210>  42
<211>  1283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of an exemplary CAR of EGFRvIII (employing 
       the alternative EGFRvIII target binding moiety encoded by SEQ ID 
       NO: 41) including an ASS-1 domain

<400>  42

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Met Asp Trp Ile 
        355                 360                 365             


Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly Ala His Ser Gln 
    370                 375                 380                 


Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser 
385                 390                 395                 400 


Leu Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly 
                405                 410                 415     


Met Ser Trp Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala 
            420                 425                 430         


Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys 
        435                 440                 445             


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu 
    450                 455                 460                 


Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
465                 470                 475                 480 


Arg Gly Tyr Ser Ser Thr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                485                 490                 495     


Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser 
        515                 520                 525             


Leu Ser Val Ala Thr Gly Glu Lys Val Thr Ile Arg Cys Met Thr Ser 
    530                 535                 540                 


Thr Asp Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu 
545                 550                 555                 560 


Pro Pro Lys Phe Leu Ile Ser Glu Gly Asn Thr Leu Arg Pro Gly Val 
                565                 570                 575     


Pro Ser Arg Phe Ser Ser Ser Gly Thr Gly Thr Asp Phe Val Phe Thr 
            580                 585                 590         


Ile Glu Asn Thr Leu Ser Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln 
        595                 600                 605             


Ser Phe Asn Val Pro Leu Thr Phe Gly Asp Gly Thr Lys Leu Glu Lys 
    610                 615                 620                 


Ala Leu Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
625                 630                 635                 640 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                645                 650                 655     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            660                 665                 670         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        675                 680                 685             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    690                 695                 700                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
705                 710                 715                 720 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                725                 730                 735     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            740                 745                 750         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        755                 760                 765             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    770                 775                 780                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
785                 790                 795                 800 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                805                 810                 815     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            820                 825                 830         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        835                 840                 845             


Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
    850                 855                 860                 


Val Glu Glu Asn Pro Gly Pro Met Ser Ser Lys Gly Ser Val Val Leu 
865                 870                 875                 880 


Ala Tyr Ser Gly Gly Leu Asp Thr Ser Cys Ile Leu Val Trp Leu Lys 
                885                 890                 895     


Glu Gln Gly Tyr Asp Val Ile Ala Tyr Leu Ala Asn Ile Gly Gln Lys 
            900                 905                 910         


Glu Asp Phe Glu Glu Ala Arg Lys Lys Ala Leu Lys Leu Gly Ala Lys 
        915                 920                 925             


Lys Val Phe Ile Glu Asp Val Ser Arg Glu Phe Val Glu Glu Phe Ile 
    930                 935                 940                 


Trp Pro Ala Ile Gln Ser Ser Ala Leu Tyr Glu Asp Arg Tyr Leu Leu 
945                 950                 955                 960 


Gly Thr Ser Leu Ala Arg Pro Cys Ile Ala Arg Lys Gln Val Glu Ile 
                965                 970                 975     


Ala Gln Arg Glu Gly Ala Lys Tyr Val Ser His Gly Ala Thr Gly Lys 
            980                 985                 990         


Gly Asn Asp Gln Val Arg Phe Glu  Leu Ser Cys Tyr Ser  Leu Ala Pro 
        995                 1000                 1005             


Gln Ile  Lys Val Ile Ala Pro  Trp Arg Met Pro Glu  Phe Tyr Asn 
    1010                 1015                 1020             


Arg Phe  Lys Gly Arg Asn Asp  Leu Met Glu Tyr Ala  Lys Gln His 
    1025                 1030                 1035             


Gly Ile  Pro Ile Pro Val Thr  Pro Lys Asn Pro Trp  Ser Met Asp 
    1040                 1045                 1050             


Glu Asn  Leu Met His Ile Ser  Tyr Glu Ala Gly Ile  Leu Glu Asn 
    1055                 1060                 1065             


Pro Lys  Asn Gln Ala Pro Pro  Gly Leu Tyr Thr Lys  Thr Gln Asp 
    1070                 1075                 1080             


Pro Ala  Lys Ala Pro Asn Thr  Pro Asp Ile Leu Glu  Ile Glu Phe 
    1085                 1090                 1095             


Lys Lys  Gly Val Pro Val Lys  Val Thr Asn Val Lys  Asp Gly Thr 
    1100                 1105                 1110             


Thr His  Gln Thr Ser Leu Glu  Leu Phe Met Tyr Leu  Asn Glu Val 
    1115                 1120                 1125             


Ala Gly  Lys His Gly Val Gly  Arg Ile Asp Ile Val  Glu Asn Arg 
    1130                 1135                 1140             


Phe Ile  Gly Met Lys Ser Arg  Gly Ile Tyr Glu Thr  Pro Ala Gly 
    1145                 1150                 1155             


Thr Ile  Leu Tyr His Ala His  Leu Asp Ile Glu Ala  Phe Thr Met 
    1160                 1165                 1170             


Asp Arg  Glu Val Arg Lys Ile  Lys Gln Gly Leu Gly  Leu Lys Phe 
    1175                 1180                 1185             


Ala Glu  Leu Val Tyr Thr Gly  Phe Trp His Ser Pro  Glu Cys Glu 
    1190                 1195                 1200             


Phe Val  Arg His Cys Ile Ala  Lys Ser Gln Glu Arg  Val Glu Gly 
    1205                 1210                 1215             


Lys Val  Gln Val Ser Val Leu  Lys Gly Gln Val Tyr  Ile Leu Gly 
    1220                 1225                 1230             


Arg Glu  Ser Pro Leu Ser Leu  Tyr Asn Glu Glu Leu  Val Ser Met 
    1235                 1240                 1245             


Asn Val  Gln Gly Asp Tyr Glu  Pro Thr Asp Ala Thr  Gly Phe Ile 
    1250                 1255                 1260             


Asn Ile  Asn Ser Leu Arg Leu  Lys Glu Tyr His Arg  Leu Gln Ser 
    1265                 1270                 1275             


Lys Val  Thr Ala Lys 
    1280             


<210>  43
<211>  1225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of an exemplary CAR of EGFRvIII (employing 
       the alternative EGFRvIII target binding moiety encoded by SEQ ID 
       NO: 41) including an OTC domain

<400>  43

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Met Asp Trp Ile 
        355                 360                 365             


Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly Ala His Ser Gln 
    370                 375                 380                 


Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser 
385                 390                 395                 400 


Leu Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly 
                405                 410                 415     


Met Ser Trp Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala 
            420                 425                 430         


Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys 
        435                 440                 445             


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu 
    450                 455                 460                 


Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
465                 470                 475                 480 


Arg Gly Tyr Ser Ser Thr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                485                 490                 495     


Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser 
        515                 520                 525             


Leu Ser Val Ala Thr Gly Glu Lys Val Thr Ile Arg Cys Met Thr Ser 
    530                 535                 540                 


Thr Asp Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu 
545                 550                 555                 560 


Pro Pro Lys Phe Leu Ile Ser Glu Gly Asn Thr Leu Arg Pro Gly Val 
                565                 570                 575     


Pro Ser Arg Phe Ser Ser Ser Gly Thr Gly Thr Asp Phe Val Phe Thr 
            580                 585                 590         


Ile Glu Asn Thr Leu Ser Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln 
        595                 600                 605             


Ser Phe Asn Val Pro Leu Thr Phe Gly Asp Gly Thr Lys Leu Glu Lys 
    610                 615                 620                 


Ala Leu Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
625                 630                 635                 640 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                645                 650                 655     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            660                 665                 670         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        675                 680                 685             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    690                 695                 700                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
705                 710                 715                 720 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                725                 730                 735     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            740                 745                 750         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        755                 760                 765             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    770                 775                 780                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
785                 790                 795                 800 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                805                 810                 815     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            820                 825                 830         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        835                 840                 845             


Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
    850                 855                 860                 


Val Glu Glu Asn Pro Gly Pro Met Leu Phe Asn Leu Arg Ile Leu Leu 
865                 870                 875                 880 


Asn Asn Ala Ala Phe Arg Asn Gly His Asn Phe Met Val Arg Asn Phe 
                885                 890                 895     


Arg Cys Gly Gln Pro Leu Gln Asn Lys Val Gln Leu Lys Gly Arg Asp 
            900                 905                 910         


Leu Leu Thr Leu Lys Asn Phe Thr Gly Glu Glu Ile Lys Tyr Met Leu 
        915                 920                 925             


Trp Leu Ser Ala Asp Leu Lys Phe Arg Ile Lys Gln Lys Gly Glu Tyr 
    930                 935                 940                 


Leu Pro Leu Leu Gln Gly Lys Ser Leu Gly Met Ile Phe Glu Lys Arg 
945                 950                 955                 960 


Ser Thr Arg Thr Arg Leu Ser Thr Glu Thr Gly Leu Ala Leu Leu Gly 
                965                 970                 975     


Gly His Pro Cys Phe Leu Thr Thr Gln Asp Ile His Leu Gly Val Asn 
            980                 985                 990         


Glu Ser Leu Thr Asp Thr Ala Arg  Val Leu Ser Ser Met  Ala Asp Ala 
        995                 1000                 1005             


Val Leu  Ala Arg Val Tyr Lys  Gln Ser Asp Leu Asp  Thr Leu Ala 
    1010                 1015                 1020             


Lys Glu  Ala Ser Ile Pro Ile  Ile Asn Gly Leu Ser  Asp Leu Tyr 
    1025                 1030                 1035             


His Pro  Ile Gln Ile Leu Ala  Asp Tyr Leu Thr Leu  Gln Glu His 
    1040                 1045                 1050             


Tyr Ser  Ser Leu Lys Gly Leu  Thr Leu Ser Trp Ile  Gly Asp Gly 
    1055                 1060                 1065             


Asn Asn  Ile Leu His Ser Ile  Met Met Ser Ala Ala  Lys Phe Gly 
    1070                 1075                 1080             


Met His  Leu Gln Ala Ala Thr  Pro Lys Gly Tyr Glu  Pro Asp Ala 
    1085                 1090                 1095             


Ser Val  Thr Lys Leu Ala Glu  Gln Tyr Ala Lys Glu  Asn Gly Thr 
    1100                 1105                 1110             


Lys Leu  Leu Leu Thr Asn Asp  Pro Leu Glu Ala Ala  His Gly Gly 
    1115                 1120                 1125             


Asn Val  Leu Ile Thr Asp Thr  Trp Ile Ser Met Gly  Gln Glu Glu 
    1130                 1135                 1140             


Glu Lys  Lys Lys Arg Leu Gln  Ala Phe Gln Gly Tyr  Gln Val Thr 
    1145                 1150                 1155             


Met Lys  Thr Ala Lys Val Ala  Ala Ser Asp Trp Thr  Phe Leu His 
    1160                 1165                 1170             


Cys Leu  Pro Arg Lys Pro Glu  Glu Val Asp Asp Glu  Val Phe Tyr 
    1175                 1180                 1185             


Ser Pro  Arg Ser Leu Val Phe  Pro Glu Ala Glu Asn  Arg Lys Trp 
    1190                 1195                 1200             


Thr Ile  Met Ala Val Met Val  Ser Leu Leu Thr Asp  Tyr Ser Pro 
    1205                 1210                 1215             


Gln Leu  Gln Lys Pro Lys Phe  
    1220                 1225 


<210>  44
<211>  1658
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of an exemplary CAR of EGFRvIII (employing 
       the alternative EGFRvIII target binding moiety encoded by SEQ ID 
       NO: 41) including an ASS-1 domain and an OTC domain

<400>  44

Met Pro Arg Gly Trp Thr Ala Leu Cys Leu Leu Ser Leu Leu Pro Ser 
1               5                   10                  15      


Gly Phe Met Ser Leu Asp Asn Asn Gly Thr Ala Thr Pro Glu Leu Pro 
            20                  25                  30          


Thr Gln Gly Thr Phe Ser Asn Val Ser Thr Asn Val Ser Tyr Gln Glu 
        35                  40                  45              


Thr Thr Thr Pro Ser Thr Leu Gly Ser Thr Ser Leu His Pro Val Ser 
    50                  55                  60                  


Gln His Gly Asn Glu Ala Thr Thr Asn Ile Thr Glu Thr Thr Val Lys 
65                  70                  75                  80  


Phe Thr Ser Thr Ser Val Ile Thr Ser Val Tyr Gly Asn Thr Asn Ser 
                85                  90                  95      


Ser Val Gln Ser Gln Thr Ser Val Ile Ser Thr Val Phe Thr Thr Pro 
            100                 105                 110         


Ala Asn Val Ser Thr Pro Glu Thr Thr Leu Lys Pro Ser Leu Ser Pro 
        115                 120                 125             


Gly Asn Val Ser Asp Leu Ser Thr Thr Ser Thr Ser Leu Ala Thr Ser 
    130                 135                 140                 


Pro Thr Lys Pro Tyr Thr Ser Ser Ser Pro Ile Leu Ser Asp Ile Lys 
145                 150                 155                 160 


Ala Glu Ile Lys Cys Ser Gly Ile Arg Glu Val Lys Leu Thr Gln Gly 
                165                 170                 175     


Ile Cys Leu Glu Gln Asn Lys Thr Ser Ser Cys Ala Glu Phe Lys Lys 
            180                 185                 190         


Asp Arg Gly Glu Gly Leu Ala Arg Val Leu Cys Gly Glu Glu Gln Ala 
        195                 200                 205             


Asp Ala Asp Ala Gly Ala Gln Val Cys Ser Leu Leu Leu Ala Gln Ser 
    210                 215                 220                 


Glu Val Arg Pro Gln Cys Leu Leu Leu Val Leu Ala Asn Arg Thr Glu 
225                 230                 235                 240 


Ile Ser Ser Lys Leu Gln Leu Met Lys Lys His Gln Ser Asp Leu Lys 
                245                 250                 255     


Lys Leu Gly Ile Leu Asp Phe Thr Glu Gln Asp Val Ala Ser His Gln 
            260                 265                 270         


Ser Tyr Ser Gln Lys Thr Leu Ile Ala Leu Val Thr Ser Gly Ala Leu 
        275                 280                 285             


Leu Ala Val Leu Gly Ile Thr Gly Tyr Phe Leu Met Asn Arg Arg Ser 
    290                 295                 300                 


Trp Ser Pro Thr Gly Glu Arg Leu Glu Leu Glu Pro Val Asp Arg Val 
305                 310                 315                 320 


Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu 
                325                 330                 335     


Ser Asn Pro Gly Pro Gly Asn Met Ala Leu Pro Val Thr Ala Leu Leu 
            340                 345                 350         


Leu Pro Leu Ala Leu Leu Leu His Ala Ala Arg Pro Met Asp Trp Ile 
        355                 360                 365             


Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly Ala His Ser Gln 
    370                 375                 380                 


Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Ala Ser 
385                 390                 395                 400 


Leu Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe Arg Lys Phe Gly 
                405                 410                 415     


Met Ser Trp Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val Ala 
            420                 425                 430         


Ser Ile Ser Thr Gly Gly Tyr Asn Thr Tyr Tyr Ser Asp Asn Val Lys 
        435                 440                 445             


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Thr Leu Tyr Leu 
    450                 455                 460                 


Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Thr 
465                 470                 475                 480 


Arg Gly Tyr Ser Ser Thr Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
                485                 490                 495     


Thr Thr Val Thr Val Ser Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly 
            500                 505                 510         


Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Ser Pro Ala Ser 
        515                 520                 525             


Leu Ser Val Ala Thr Gly Glu Lys Val Thr Ile Arg Cys Met Thr Ser 
    530                 535                 540                 


Thr Asp Ile Asp Asp Asp Met Asn Trp Tyr Gln Gln Lys Pro Gly Glu 
545                 550                 555                 560 


Pro Pro Lys Phe Leu Ile Ser Glu Gly Asn Thr Leu Arg Pro Gly Val 
                565                 570                 575     


Pro Ser Arg Phe Ser Ser Ser Gly Thr Gly Thr Asp Phe Val Phe Thr 
            580                 585                 590         


Ile Glu Asn Thr Leu Ser Glu Asp Val Gly Asp Tyr Tyr Cys Leu Gln 
        595                 600                 605             


Ser Phe Asn Val Pro Leu Thr Phe Gly Asp Gly Thr Lys Leu Glu Lys 
    610                 615                 620                 


Ala Leu Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
625                 630                 635                 640 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
                645                 650                 655     


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
            660                 665                 670         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        675                 680                 685             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    690                 695                 700                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
705                 710                 715                 720 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                725                 730                 735     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln 
            740                 745                 750         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        755                 760                 765             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    770                 775                 780                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
785                 790                 795                 800 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                805                 810                 815     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            820                 825                 830         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        835                 840                 845             


Arg Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
    850                 855                 860                 


Val Glu Glu Asn Pro Gly Pro Met Ser Ser Lys Gly Ser Val Val Leu 
865                 870                 875                 880 


Ala Tyr Ser Gly Gly Leu Asp Thr Ser Cys Ile Leu Val Trp Leu Lys 
                885                 890                 895     


Glu Gln Gly Tyr Asp Val Ile Ala Tyr Leu Ala Asn Ile Gly Gln Lys 
            900                 905                 910         


Glu Asp Phe Glu Glu Ala Arg Lys Lys Ala Leu Lys Leu Gly Ala Lys 
        915                 920                 925             


Lys Val Phe Ile Glu Asp Val Ser Arg Glu Phe Val Glu Glu Phe Ile 
    930                 935                 940                 


Trp Pro Ala Ile Gln Ser Ser Ala Leu Tyr Glu Asp Arg Tyr Leu Leu 
945                 950                 955                 960 


Gly Thr Ser Leu Ala Arg Pro Cys Ile Ala Arg Lys Gln Val Glu Ile 
                965                 970                 975     


Ala Gln Arg Glu Gly Ala Lys Tyr Val Ser His Gly Ala Thr Gly Lys 
            980                 985                 990         


Gly Asn Asp Gln Val Arg Phe Glu  Leu Ser Cys Tyr Ser  Leu Ala Pro 
        995                 1000                 1005             


Gln Ile  Lys Val Ile Ala Pro  Trp Arg Met Pro Glu  Phe Tyr Asn 
    1010                 1015                 1020             


Arg Phe  Lys Gly Arg Asn Asp  Leu Met Glu Tyr Ala  Lys Gln His 
    1025                 1030                 1035             


Gly Ile  Pro Ile Pro Val Thr  Pro Lys Asn Pro Trp  Ser Met Asp 
    1040                 1045                 1050             


Glu Asn  Leu Met His Ile Ser  Tyr Glu Ala Gly Ile  Leu Glu Asn 
    1055                 1060                 1065             


Pro Lys  Asn Gln Ala Pro Pro  Gly Leu Tyr Thr Lys  Thr Gln Asp 
    1070                 1075                 1080             


Pro Ala  Lys Ala Pro Asn Thr  Pro Asp Ile Leu Glu  Ile Glu Phe 
    1085                 1090                 1095             


Lys Lys  Gly Val Pro Val Lys  Val Thr Asn Val Lys  Asp Gly Thr 
    1100                 1105                 1110             


Thr His  Gln Thr Ser Leu Glu  Leu Phe Met Tyr Leu  Asn Glu Val 
    1115                 1120                 1125             


Ala Gly  Lys His Gly Val Gly  Arg Ile Asp Ile Val  Glu Asn Arg 
    1130                 1135                 1140             


Phe Ile  Gly Met Lys Ser Arg  Gly Ile Tyr Glu Thr  Pro Ala Gly 
    1145                 1150                 1155             


Thr Ile  Leu Tyr His Ala His  Leu Asp Ile Glu Ala  Phe Thr Met 
    1160                 1165                 1170             


Asp Arg  Glu Val Arg Lys Ile  Lys Gln Gly Leu Gly  Leu Lys Phe 
    1175                 1180                 1185             


Ala Glu  Leu Val Tyr Thr Gly  Phe Trp His Ser Pro  Glu Cys Glu 
    1190                 1195                 1200             


Phe Val  Arg His Cys Ile Ala  Lys Ser Gln Glu Arg  Val Glu Gly 
    1205                 1210                 1215             


Lys Val  Gln Val Ser Val Leu  Lys Gly Gln Val Tyr  Ile Leu Gly 
    1220                 1225                 1230             


Arg Glu  Ser Pro Leu Ser Leu  Tyr Asn Glu Glu Leu  Val Ser Met 
    1235                 1240                 1245             


Asn Val  Gln Gly Asp Tyr Glu  Pro Thr Asp Ala Thr  Gly Phe Ile 
    1250                 1255                 1260             


Asn Ile  Asn Ser Leu Arg Leu  Lys Glu Tyr His Arg  Leu Gln Ser 
    1265                 1270                 1275             


Lys Val  Thr Ala Lys Gly Ser  Gly Glu Gly Arg Gly  Ser Leu Leu 
    1280                 1285                 1290             


Thr Cys  Gly Asp Val Glu Glu  Asn Pro Gly Pro Met  Leu Phe Asn 
    1295                 1300                 1305             


Leu Arg  Ile Leu Leu Asn Asn  Ala Ala Phe Arg Asn  Gly His Asn 
    1310                 1315                 1320             


Phe Met  Val Arg Asn Phe Arg  Cys Gly Gln Pro Leu  Gln Asn Lys 
    1325                 1330                 1335             


Val Gln  Leu Lys Gly Arg Asp  Leu Leu Thr Leu Lys  Asn Phe Thr 
    1340                 1345                 1350             


Gly Glu  Glu Ile Lys Tyr Met  Leu Trp Leu Ser Ala  Asp Leu Lys 
    1355                 1360                 1365             


Phe Arg  Ile Lys Gln Lys Gly  Glu Tyr Leu Pro Leu  Leu Gln Gly 
    1370                 1375                 1380             


Lys Ser  Leu Gly Met Ile Phe  Glu Lys Arg Ser Thr  Arg Thr Arg 
    1385                 1390                 1395             


Leu Ser  Thr Glu Thr Gly Leu  Ala Leu Leu Gly Gly  His Pro Cys 
    1400                 1405                 1410             


Phe Leu  Thr Thr Gln Asp Ile  His Leu Gly Val Asn  Glu Ser Leu 
    1415                 1420                 1425             


Thr Asp  Thr Ala Arg Val Leu  Ser Ser Met Ala Asp  Ala Val Leu 
    1430                 1435                 1440             


Ala Arg  Val Tyr Lys Gln Ser  Asp Leu Asp Thr Leu  Ala Lys Glu 
    1445                 1450                 1455             


Ala Ser  Ile Pro Ile Ile Asn  Gly Leu Ser Asp Leu  Tyr His Pro 
    1460                 1465                 1470             


Ile Gln  Ile Leu Ala Asp Tyr  Leu Thr Leu Gln Glu  His Tyr Ser 
    1475                 1480                 1485             


Ser Leu  Lys Gly Leu Thr Leu  Ser Trp Ile Gly Asp  Gly Asn Asn 
    1490                 1495                 1500             


Ile Leu  His Ser Ile Met Met  Ser Ala Ala Lys Phe  Gly Met His 
    1505                 1510                 1515             


Leu Gln  Ala Ala Thr Pro Lys  Gly Tyr Glu Pro Asp  Ala Ser Val 
    1520                 1525                 1530             


Thr Lys  Leu Ala Glu Gln Tyr  Ala Lys Glu Asn Gly  Thr Lys Leu 
    1535                 1540                 1545             


Leu Leu  Thr Asn Asp Pro Leu  Glu Ala Ala His Gly  Gly Asn Val 
    1550                 1555                 1560             


Leu Ile  Thr Asp Thr Trp Ile  Ser Met Gly Gln Glu  Glu Glu Lys 
    1565                 1570                 1575             


Lys Lys  Arg Leu Gln Ala Phe  Gln Gly Tyr Gln Val  Thr Met Lys 
    1580                 1585                 1590             


Thr Ala  Lys Val Ala Ala Ser  Asp Trp Thr Phe Leu  His Cys Leu 
    1595                 1600                 1605             


Pro Arg  Lys Pro Glu Glu Val  Asp Asp Glu Val Phe  Tyr Ser Pro 
    1610                 1615                 1620             


Arg Ser  Leu Val Phe Pro Glu  Ala Glu Asn Arg Lys  Trp Thr Ile 
    1625                 1630                 1635             


Met Ala  Val Met Val Ser Leu  Leu Thr Asp Tyr Ser  Pro Gln Leu 
    1640                 1645                 1650             


Gln Lys  Pro Lys Phe 
    1655             


