                         SEQUENCE LISTING

<110>  Pepperprint GmbH
 
<120>  NS2b as marker for Zika virus infections

<130>  U30830WO

<150>  EP 17 209 651.3
<151>  2017-12-21

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Flavivirus Zika

<400>  1

Gly Asp Ile Thr Trp Glu Lys Asp Ala Glu Val Thr Gly Asn Ser Pro 
1               5                   10                  15      


Arg Leu Asp Val Ala 
            20      


<210>  2
<211>  15
<212>  PRT
<213>  Flavivirus Zika

<400>  2

Gly Asp Ile Thr Trp Glu Lys Asp Ala Glu Val Thr Gly Asn Ser 
1               5                   10                  15  


<210>  3
<211>  15
<212>  PRT
<213>  Flavivirus Zika

<400>  3

Gly Asp Ile Thr Trp Glu Lys Asp Ala Glu Ile Thr Gly Asn Ser 
1               5                   10                  15  


<210>  4
<211>  15
<212>  PRT
<213>  Flavivirus Zika

<400>  4

Thr Trp Glu Lys Asp Ala Glu Val Thr Gly Asn Ser Pro Arg Leu 
1               5                   10                  15  


<210>  5
<211>  15
<212>  PRT
<213>  Flavivirus Zika

<400>  5

Thr Trp Glu Lys Asp Ala Glu Ile Thr Gly Asn Ser Pro Arg Leu 
1               5                   10                  15  


<210>  6
<211>  15
<212>  PRT
<213>  Flavivirus Zika

<400>  6

Lys Asp Ala Glu Val Thr Gly Asn Ser Pro Arg Leu Asp Val Ala 
1               5                   10                  15  


<210>  7
<211>  15
<212>  PRT
<213>  Flavivirus Zika

<400>  7

Lys Asp Ala Glu Ile Thr Gly Asn Ser Pro Arg Leu Asp Val Ala 
1               5                   10                  15  


<210>  8
<211>  21
<212>  PRT
<213>  Flavivirus Zika

<400>  8

Gly Asp Ile Thr Trp Glu Lys Asp Ala Glu Ile Thr Gly Asn Ser Pro 
1               5                   10                  15      


Arg Leu Asp Val Ala 
            20      


<210>  9
<211>  15
<212>  PRT
<213>  Flavivirus Zika

<400>  9

Trp Glu Lys Asp Ala Glu Val Thr Gly Asn Ser Pro Arg Leu Asp 
1               5                   10                  15  


<210>  10
<211>  9
<212>  PRT
<213>  Flavivirus Zika

<400>  10

Lys Asp Ala Glu Val Thr Gly Asn Ser 
1               5                   


<210>  11
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide with SEQ ID NO.9 substituted in position 9 and 11

<400>  11

Trp Glu Lys Asp Pro Glu Asp Thr Gly Asn Ser Pro Arg Leu Asp 
1               5                   10                  15  


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide with SEQ ID NO.9 substituted in position 9

<400>  12

Trp Glu Lys Asp Ala Glu Asp Thr Gly Asn Ser Pro Arg Leu Asp 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide with SEQ ID NO.9 substituted in position 9, 11 and 15

<400>  13

Trp Glu Lys Asp Pro Glu Asp Thr Gly Asn Lys Pro Arg Leu Asp 
1               5                   10                  15  


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide with SEQ ID NO. 10 substituted in position 9 and 11

<400>  14

Lys Asp Pro Glu Asp Thr Gly Asn Ser 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide with SEQ ID NO. 10 substituted in position 9

<400>  15

Lys Asp Ala Glu Asp Thr Gly Asn Ser 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide with SEQ ID NO. 10 substituted in position 9, 11 and 15

<400>  16

Lys Asp Pro Glu Asp Thr Gly Asn Lys 
1               5                   


<210>  17
<211>  130
<212>  PRT
<213>  Flavivirus Zika

<400>  17

Ser Trp Pro Pro Ser Glu Val Leu Thr Ala Val Gly Leu Ile Cys Ala 
1               5                   10                  15      


Leu Ala Gly Gly Phe Ala Lys Ala Asp Ile Glu Met Ala Gly Pro Met 
            20                  25                  30          


Ala Ala Val Gly Leu Leu Ile Val Ser Tyr Val Val Ser Gly Lys Ser 
        35                  40                  45              


Val Asp Met Tyr Ile Glu Arg Ala Gly Asp Ile Thr Trp Glu Lys Asp 
    50                  55                  60                  


Ala Glu Val Thr Gly Asn Ser Pro Arg Leu Asp Val Ala Leu Asp Glu 
65                  70                  75                  80  


Ser Gly Asp Phe Ser Leu Val Glu Glu Asp Gly Pro Pro Met Arg Glu 
                85                  90                  95      


Ile Ile Leu Lys Val Val Leu Met Ala Ile Cys Gly Met Asn Pro Ile 
            100                 105                 110         


Ala Ile Pro Phe Ala Ala Gly Ala Trp Tyr Val Tyr Val Lys Thr Gly 
        115                 120                 125             


Lys Arg 
    130 


<210>  18
<211>  21
<212>  PRT
<213>  West Nile virus

<400>  18

Ala Asp Ile Thr Trp Glu Ser Asp Ala Glu Ile Thr Gly Ser Ser Glu 
1               5                   10                  15      


Arg Val Asp Val Arg 
            20      


<210>  19
<211>  131
<212>  PRT
<213>  West Nile virus

<400>  19

Gly Trp Pro Ala Thr Glu Val Met Thr Ala Val Gly Leu Met Phe Ala 
1               5                   10                  15      


Ile Val Gly Gly Leu Ala Glu Leu Asp Ile Asp Ser Met Ala Ile Pro 
            20                  25                  30          


Met Thr Ile Ala Gly Leu Met Phe Ala Ala Phe Val Ile Ser Gly Lys 
        35                  40                  45              


Ser Thr Asp Met Trp Ile Glu Arg Thr Ala Asp Ile Thr Trp Glu Ser 
    50                  55                  60                  


Asp Ala Glu Ile Thr Gly Ser Ser Glu Arg Val Asp Val Arg Leu Asp 
65                  70                  75                  80  


Asp Asp Gly Asn Phe Gln Leu Met Asn Asp Pro Gly Ala Pro Trp Lys 
                85                  90                  95      


Ile Trp Met Leu Arg Met Ala Cys Leu Ala Ile Ser Ala Tyr Thr Pro 
            100                 105                 110         


Trp Ala Ile Leu Pro Ser Val Ile Gly Phe Trp Ile Thr Leu Gln Tyr 
        115                 120                 125             


Thr Lys Arg 
    130     


<210>  20
<211>  21
<212>  PRT
<213>  Dengue virus type 1

<400>  20

Ala Glu Val Ser Trp Glu Glu Glu Ala Glu His Ser Gly Ala Ser His 
1               5                   10                  15      


Asn Ile Leu Val Glu 
            20      


<210>  21
<211>  130
<212>  PRT
<213>  Dengue virus type 1

<400>  21

Ser Trp Pro Leu Asn Glu Gly Ile Met Ala Val Gly Ile Val Ser Ile 
1               5                   10                  15      


Leu Leu Ser Ser Leu Leu Lys Asn Asp Val Pro Leu Ala Gly Pro Leu 
            20                  25                  30          


Ile Ala Gly Gly Met Leu Ile Ala Cys Tyr Val Ile Ser Gly Ser Ser 
        35                  40                  45              


Ala Asp Leu Ser Leu Glu Lys Ala Ala Glu Val Ser Trp Glu Glu Glu 
    50                  55                  60                  


Ala Glu His Ser Gly Ala Ser His Asn Ile Leu Val Glu Val Gln Asp 
65                  70                  75                  80  


Asp Gly Thr Met Lys Ile Lys Asp Glu Glu Arg Asp Asp Thr Leu Thr 
                85                  90                  95      


Ile Leu Leu Lys Ala Thr Leu Leu Ala Ile Ser Gly Val Tyr Pro Met 
            100                 105                 110         


Ser Ile Pro Ala Thr Leu Phe Val Trp Tyr Phe Trp Gln Lys Lys Lys 
        115                 120                 125             


Gln Arg 
    130 


<210>  22
<211>  21
<212>  PRT
<213>  Dengue virus type 2

<400>  22

Ala Asp Val Lys Trp Glu Asp Gln Ala Glu Ile Ser Gly Ser Ser Pro 
1               5                   10                  15      


Ile Leu Ser Ile Thr 
            20      


<210>  23
<211>  130
<212>  PRT
<213>  Dengue virus type 2

<400>  23

Ser Trp Pro Leu Asn Glu Ala Ile Met Ala Val Gly Met Val Ser Ile 
1               5                   10                  15      


Leu Ala Ser Ser Leu Leu Lys Asn Asp Ile Pro Met Thr Gly Pro Leu 
            20                  25                  30          


Val Ala Gly Gly Pro Leu Thr Val Cys Tyr Val Leu Thr Gly Arg Ser 
        35                  40                  45              


Ala Asp Leu Glu Leu Glu Arg Ala Ala Asp Val Lys Trp Glu Asp Gln 
    50                  55                  60                  


Ala Glu Ile Ser Gly Ser Ser Pro Ile Leu Ser Ile Thr Ile Ser Glu 
65                  70                  75                  80  


Asp Gly Ser Met Ser Ile Lys Asn Glu Glu Glu Glu Gln Thr Leu Thr 
                85                  90                  95      


Ile Leu Ile Arg Thr Gly Leu Leu Val Ile Ser Gly Leu Phe Pro Val 
            100                 105                 110         


Ser Ile Pro Ile Thr Ala Ala Ala Trp Tyr Leu Trp Glu Val Lys Lys 
        115                 120                 125             


Gln Arg 
    130 


<210>  24
<211>  21
<212>  PRT
<213>  Dengue virus type 3

<400>  24

Pro Asp Val Thr Trp Glu Glu Glu Ala Glu Gln Thr Gly Val Ser His 
1               5                   10                  15      


Asn Leu Met Ile Thr 
            20      


<210>  25
<211>  130
<212>  PRT
<213>  Dengue virus type 3

<400>  25

Ser Trp Pro Leu Asn Glu Gly Val Met Ala Val Gly Leu Val Ser Ile 
1               5                   10                  15      


Leu Ala Ser Ser Leu Leu Arg Asn Asp Val Pro Met Ala Gly Pro Leu 
            20                  25                  30          


Val Ala Gly Gly Leu Leu Ile Ala Cys Tyr Val Ile Thr Gly Thr Ser 
        35                  40                  45              


Ala Asp Leu Thr Val Glu Lys Ala Pro Asp Val Thr Trp Glu Glu Glu 
    50                  55                  60                  


Ala Glu Gln Thr Gly Val Ser His Asn Leu Met Ile Thr Val Asp Asp 
65                  70                  75                  80  


Asp Gly Thr Met Arg Ile Lys Asp Asp Glu Thr Glu Asn Ile Leu Thr 
                85                  90                  95      


Val Leu Leu Lys Thr Ala Leu Leu Ile Val Ser Gly Ile Phe Pro Tyr 
            100                 105                 110         


Ser Ile Pro Ala Thr Leu Leu Val Trp His Thr Trp Gln Lys Gln Thr 
        115                 120                 125             


Gln Arg 
    130 


<210>  26
<211>  21
<212>  PRT
<213>  Yellow fever virus

<400>  26

Gly Glu Val Ser Trp Glu Glu Glu Ala Glu Ile Ser Gly Ser Ser Ala 
1               5                   10                  15      


Arg Tyr Asp Val Ala 
            20      


<210>  27
<211>  130
<212>  PRT
<213>  Yellow fever virus

<400>  27

Ser Ile Pro Val Asn Glu Ala Leu Ala Ala Ala Gly Leu Val Gly Val 
1               5                   10                  15      


Leu Ala Gly Leu Ala Phe Gln Glu Met Glu Asn Phe Leu Gly Pro Ile 
            20                  25                  30          


Ala Val Gly Gly Leu Leu Met Met Leu Val Ser Val Ala Gly Arg Val 
        35                  40                  45              


Asp Gly Leu Glu Leu Lys Lys Leu Gly Glu Val Ser Trp Glu Glu Glu 
    50                  55                  60                  


Ala Glu Ile Ser Gly Ser Ser Ala Arg Tyr Asp Val Ala Leu Ser Glu 
65                  70                  75                  80  


Gln Gly Glu Phe Lys Leu Leu Ser Glu Glu Lys Val Pro Trp Asp Gln 
                85                  90                  95      


Val Val Met Thr Ser Leu Ala Leu Val Gly Ala Ala Leu His Pro Phe 
            100                 105                 110         


Ala Leu Leu Leu Val Leu Ala Gly Trp Leu Phe His Val Arg Gly Ala 
        115                 120                 125             


Arg Arg 
    130 


<210>  28
<211>  21
<212>  PRT
<213>  Dengue virus type 4

<400>  28

Ala Asn Val Gln Trp Asp Glu Met Ala Asp Ile Thr Gly Ser Ser Pro 
1               5                   10                  15      


Ile Ile Glu Val Lys 
            20      


<210>  29
<211>  130
<212>  PRT
<213>  Dengue virus type 4

<400>  29

Ser Trp Pro Leu Asn Glu Gly Ile Met Ala Val Gly Leu Val Ser Leu 
1               5                   10                  15      


Leu Gly Ser Ala Leu Leu Lys Asn Asp Val Pro Leu Ala Gly Pro Met 
            20                  25                  30          


Val Ala Gly Gly Leu Leu Leu Ala Ala Tyr Val Met Ser Gly Ser Ser 
        35                  40                  45              


Ala Asp Leu Ser Leu Glu Lys Ala Ala Asn Val Gln Trp Asp Glu Met 
    50                  55                  60                  


Ala Asp Ile Thr Gly Ser Ser Pro Ile Ile Glu Val Lys Gln Asp Glu 
65                  70                  75                  80  


Asp Gly Ser Phe Ser Ile Arg Asp Val Glu Glu Thr Asn Met Ile Thr 
                85                  90                  95      


Leu Leu Val Lys Leu Ala Leu Ile Thr Val Ser Gly Leu Tyr Pro Leu 
            100                 105                 110         


Ala Ile Pro Val Thr Met Thr Leu Trp Tyr Met Trp Gln Val Lys Thr 
        115                 120                 125             


Gln Arg 
    130 


<210>  30
<211>  21
<212>  PRT
<213>  Tick-borne encephalitis virus

<400>  30

Gly Cys Val Glu Trp Tyr Pro Glu Leu Val Asn Glu Gly Gly Glu Val 
1               5                   10                  15      


Ser Leu Arg Val Arg 
            20      


<210>  31
<211>  131
<212>  PRT
<213>  Tick-borne encephalitis virus

<400>  31

Ser Phe Ser Glu Pro Leu Thr Val Val Gly Val Met Leu Thr Leu Ala 
1               5                   10                  15      


Ser Gly Met Met Arg His Thr Ser Gln Glu Ala Leu Cys Ala Leu Ala 
            20                  25                  30          


Val Ala Ser Phe Leu Leu Leu Met Leu Val Leu Gly Thr Arg Lys Met 
        35                  40                  45              


Gln Leu Val Ala Glu Trp Ser Gly Cys Val Glu Trp Tyr Pro Glu Leu 
    50                  55                  60                  


Val Asn Glu Gly Gly Glu Val Ser Leu Arg Val Arg Gln Asp Ala Met 
65                  70                  75                  80  


Gly Asn Phe His Leu Thr Glu Leu Glu Lys Glu Glu Arg Met Met Ala 
                85                  90                  95      


Phe Trp Leu Ile Ala Gly Leu Ala Ala Ser Ala Ile His Trp Ser Gly 
            100                 105                 110         


Ile Leu Gly Val Met Gly Leu Trp Thr Leu Thr Glu Met Leu Arg Ser 
        115                 120                 125             


Ser Arg Arg 
    130     


<210>  32
<211>  21
<212>  PRT
<213>  Japanese encephalitis virus

<400>  32

Ala Thr Asp Met Trp Leu Glu Arg Ala Ala Asp Ile Ser Trp Glu Met 
1               5                   10                  15      


Asp Ala Ala Ile Thr 
            20      


<210>  33
<211>  131
<212>  PRT
<213>  Japanese encephalitis virus

<400>  33

Gly Trp Pro Ala Thr Glu Phe Leu Ser Ala Val Gly Leu Met Phe Ala 
1               5                   10                  15      


Ile Val Gly Gly Leu Ala Glu Leu Asp Ile Glu Ser Met Ser Ile Pro 
            20                  25                  30          


Phe Met Leu Ala Gly Leu Met Ala Val Ser Tyr Val Val Ser Gly Lys 
        35                  40                  45              


Ala Thr Asp Met Trp Leu Glu Arg Ala Ala Asp Ile Ser Trp Glu Met 
    50                  55                  60                  


Asp Ala Ala Ile Thr Gly Ser Ser Arg Arg Leu Asp Val Lys Leu Asp 
65                  70                  75                  80  


Asp Asp Gly Asp Phe His Leu Ile Asp Asp Pro Gly Val Pro Trp Lys 
                85                  90                  95      


Val Trp Val Leu Arg Met Ser Cys Ile Gly Leu Ala Ala Leu Thr Pro 
            100                 105                 110         


Trp Ala Ile Val Pro Ala Ala Phe Gly Tyr Trp Leu Thr Leu Lys Thr 
        115                 120                 125             


Thr Lys Arg 
    130     


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, derived from SEQ ID NO. 9, with K7 substitution, wherein
       X is any amino acid except K (lysine)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  34

Trp Glu Xaa Asp Ala Glu Val Thr Gly Asn Ser Pro Arg Leu Asp 
1               5                   10                  15  


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, derived from SEQ ID NO. 10, with K7 substitution, 
       wherein X is any amino acid except K (lysine)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  35

Xaa Asp Ala Glu Val Thr Gly Asn Ser 
1               5                   


<210>  36
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, derived from SEQ ID NO. 11, with K7 substitution, 
       wherein X is any amino acid except K (lysine)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  36

Trp Glu Xaa Asp Pro Glu Asp Thr Gly Asn Ser Pro Arg Leu Asp 
1               5                   10                  15  


<210>  37
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, derived from SEQ ID NO. 12, with K7 substitution, 
       wherein X is any amino acid except K (lysine)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  37

Trp Glu Xaa Asp Ala Glu Asp Thr Gly Asn Ser Pro Arg Leu Asp 
1               5                   10                  15  


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, derived from SEQ ID NO. 13, with K7 substitution, 
       wherein X is any amino acid except K (lysine)


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  38

Trp Glu Xaa Asp Pro Glu Asp Thr Gly Asn Lys Pro Arg Leu Asp 
1               5                   10                  15  


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, derived from SEQ ID NO. 14, with K7 substitution, 
       wherein X is any amino acid except K (lysine)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  39

Xaa Asp Pro Glu Asp Thr Gly Asn Ser 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, derived from SEQ ID NO. 15, with K7 substitution, 
       wherein X is any amino acid except K (lysine)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  40

Xaa Asp Ala Glu Asp Thr Gly Asn Ser 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide, derived from SEQ ID NO. 16, with K7 substitution, 
       wherein X is any amino acid except K (lysine)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  41

Xaa Asp Pro Glu Asp Thr Gly Asn Lys 
1               5                   


