                         SEQUENCE LISTING

<110>  CIC NANOGUNE - ASOCIACIN CENTRO DE INVESTIGACIN 
       COOPERATIVA EN NANOCIENCIAS
       UNIVERSIDAD DEL PAIS VASCO
 
<120>  ANCESTRAL CELLULASES AND USES THEREOF

<130>  P15507PC00

<150>  EP17382862.5
<151>  2017-12-19

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ancestral exoglucanase catalytic domain

<400>  1

Asp Asn Ala Tyr Glu Gln Arg Phe Leu Asp Met Tyr Asn Lys Ile Lys 
1               5                   10                  15      


Asp Pro Ala Asn Gly Tyr Phe Ser Pro Glu Gly Ile Pro Tyr His Ser 
            20                  25                  30          


Val Glu Thr Leu Ile Val Glu Ala Pro Asp Tyr Gly His Glu Thr Thr 
        35                  40                  45              


Ser Glu Ala Phe Ser Tyr Tyr Leu Trp Leu Glu Ala Met Tyr Gly Arg 
    50                  55                  60                  


Phe Thr Gly Asp Trp Ser Gly Phe Asn Asn Ala Trp Asp Thr Met Glu 
65                  70                  75                  80  


Lys Tyr Ile Ile Pro Ser His Ala Asp Gln Pro Thr Thr Ser Ser Tyr 
                85                  90                  95      


Asn Pro Asn Lys Pro Ala Thr Tyr Ala Pro Glu His Pro Asp Pro Ser 
            100                 105                 110         


Gln Tyr Pro Ser Gln Leu Asp Ser Ser Ala Pro Val Gly Lys Asp Pro 
        115                 120                 125             


Ile Asp Asn Glu Leu Lys Ser Thr Tyr Gly Thr Asn Gln Ile Tyr Gly 
    130                 135                 140                 


Met His Trp Leu Leu Asp Val Asp Asn Trp Tyr Gly Phe Gly Asn Ser 
145                 150                 155                 160 


Pro Gly Arg Cys Glu Asp Gly Asp Ser Thr Thr Arg Pro Ala Tyr Ile 
                165                 170                 175     


Asn Thr Phe Gln Arg Gly Glu Gln Glu Ser Val Trp Glu Thr Ile Pro 
            180                 185                 190         


Gln Pro Ser Arg Asp Glu Met Lys Tyr Gly Gly Pro Asn Gly Phe Leu 
        195                 200                 205             


Asp Leu Phe Thr Gly Asp Ser Gln Tyr Pro Ala Lys Gln Trp Lys Tyr 
    210                 215                 220                 


Thr Asn Ala Pro Asp Ala Asp Ala Arg Ala Val Gln Ala Thr Tyr Trp 
225                 230                 235                 240 


Ala His Glu Trp Ala Lys Glu Gln Gly Val Ala Ser Asn Val Ser Ala 
                245                 250                 255     


Tyr Val Ala Lys Ala Thr Lys Met Gly Asp Tyr Leu Arg Tyr Ser Met 
            260                 265                 270         


Phe Asp Lys Tyr Phe Arg Lys Ile Gly Asn Cys Val Gly Ala Ser Ser 
        275                 280                 285             


Thr Pro Ala Gly Thr Gly Lys Asp Ser Ala His Tyr Leu Leu Ser Trp 
    290                 295                 300                 


Tyr Tyr Ala Trp Gly Gly Gly Ile Asp Thr Ser Ala Asn Trp Ala Trp 
305                 310                 315                 320 


Arg Ile Gly Ser Ser His Ser His Phe Gly Tyr Gln Asn Pro Met Ala 
                325                 330                 335     


Ala Trp Ala Leu Ser Asn Ala Ser Glu Leu Lys Pro Lys Ser Pro Thr 
            340                 345                 350         


Gly Ala Ser Asp Trp Ala Lys Ser Leu Lys Arg Gln Leu Glu Phe Tyr 
        355                 360                 365             


Gln Trp Leu Gln Ser Ser Glu Gly Ala Ile Ala Gly Gly Ala Thr Asn 
    370                 375                 380                 


Ser Trp Asn Gly Ser Tyr Ala Thr Trp Pro Ala Gly Thr Ser Thr Phe 
385                 390                 395                 400 


Tyr Gly Met Gly Tyr Glu Glu Gln Pro Val Tyr His Asp Pro Pro Ser 
                405                 410                 415     


Asn Gln Trp Phe Gly Met Gln Ala Trp Ser Met Glu Arg Val Ala Glu 
            420                 425                 430         


Tyr Tyr Tyr Lys Thr Gly Asp Thr Arg Ala Lys Ser Val Leu Asp Lys 
        435                 440                 445             


Trp Val Lys Trp Ala Lys Ala Asn Val Thr Ile Asn Ala Asp Gly Thr 
    450                 455                 460                 


Phe Gln Ile Pro Gly Asn Leu Glu Trp Ser Gly Gln Pro Asp Thr Trp 
465                 470                 475                 480 


Thr Ala Ser Tyr Thr Gly Ala Asn Pro Asn Leu His Val Thr Val Lys 
                485                 490                 495     


Asn Tyr Gly Gln Asp Val Gly Val Ala Gly Ser Leu Ala Lys Ala Leu 
            500                 505                 510         


Thr Tyr Tyr Ala Ala Lys Ser Gly Asn Thr Thr Ala Lys Asp Thr Ala 
        515                 520                 525             


Lys Lys Leu Leu Asp Ala Leu Asn Asn Tyr Gln Asp Ser Lys Gly Ile 
    530                 535                 540                 


Ala Val Pro Glu Thr Arg Ala Asp Tyr Asn Arg Phe Phe Asp Glu Val 
545                 550                 555                 560 


Tyr Val Pro Ser Gly Trp Thr Gly Thr Met Pro Asn Gly Asp Val Ile 
                565                 570                 575     


Lys Ser Gly Ala Thr Phe Leu Asp Ile Arg Ser Lys Tyr Lys Gln Asp 
            580                 585                 590         


Pro Asp Trp Pro Lys Val Glu Ala Ala Leu Gln Ser Gly Pro Ala Pro 
        595                 600                 605             


Thr Phe Thr Tyr His Arg Phe Trp Ala Gln Val Asp Ile Ala Thr Ala 
    610                 615                 620                 


Tyr Ala 
625     


<210>  2
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ancestral exoglucanase catalytic domain

<400>  2

Asp Asn Ala Tyr Asp Gln Arg Phe Leu Thr Met Tyr Asn Lys Ile Lys 
1               5                   10                  15      


Asp Pro Ala Asn Gly Tyr Phe Ser Pro Glu Gly Val Pro Tyr His Ser 
            20                  25                  30          


Val Glu Thr Leu Ile Val Glu Ala Pro Asp His Gly His Glu Thr Thr 
        35                  40                  45              


Ser Glu Ala Phe Ser Tyr Tyr Leu Trp Leu Glu Ala Met Tyr Gly Arg 
    50                  55                  60                  


Val Thr Gly Asp Trp Ser Pro Phe Asn Asn Ala Trp Asp Thr Met Glu 
65                  70                  75                  80  


Lys Tyr Ile Ile Pro Ser His Ala Asp Gln Pro Thr Asn Ser Ser Tyr 
                85                  90                  95      


Asn Pro Ser Lys Pro Ala Thr Tyr Ala Pro Glu His Pro Asp Pro Ser 
            100                 105                 110         


Gln Tyr Pro Ser Gln Leu Asp Ser Ser Val Pro Val Gly Gln Asp Pro 
        115                 120                 125             


Ile Ala Asn Glu Leu Lys Ser Thr Tyr Gly Thr Asn Asp Ile Tyr Gly 
    130                 135                 140                 


Met His Trp Leu Leu Asp Val Asp Asn Val Tyr Gly Phe Gly Asn Ser 
145                 150                 155                 160 


Pro Gly Arg Cys Glu Asp Gly Asp Ser Thr Thr Arg Pro Ala Tyr Ile 
                165                 170                 175     


Asn Thr Phe Gln Arg Gly Pro Gln Glu Ser Val Trp Glu Thr Val Pro 
            180                 185                 190         


Gln Pro Ser Cys Asp Thr Phe Lys Tyr Gly Gly Pro Asn Gly Tyr Leu 
        195                 200                 205             


Asp Leu Phe Thr Gly Asp Ser Ser Tyr Pro Ala Lys Gln Trp Lys Tyr 
    210                 215                 220                 


Thr Asn Ala Pro Asp Ala Asp Ala Arg Ala Val Gln Ala Ala Tyr Trp 
225                 230                 235                 240 


Ala His Glu Trp Ala Lys Glu Gln Gly Lys Ala Ser Glu Val Ala Ala 
                245                 250                 255     


Thr Val Ala Lys Ala Ala Lys Met Gly Asp Tyr Leu Arg Tyr Ser Met 
            260                 265                 270         


Phe Asp Lys Tyr Phe Lys Lys Ile Gly Asn Cys Val Gly Ala Ser Ser 
        275                 280                 285             


Cys Pro Ala Gly Thr Gly Lys Asp Ser Ala His Tyr Leu Leu Ser Trp 
    290                 295                 300                 


Tyr Tyr Ala Trp Gly Gly Ala Thr Asp Thr Ser Ala Gly Trp Ala Trp 
305                 310                 315                 320 


Arg Ile Gly Ser Ser His Ser His Phe Gly Tyr Gln Asn Pro Met Ala 
                325                 330                 335     


Ala Trp Ala Leu Ser Asn Val Ala Glu Leu Lys Pro Lys Ser Pro Thr 
            340                 345                 350         


Gly Ala Ser Asp Trp Ala Thr Ser Leu Lys Arg Gln Leu Glu Phe Tyr 
        355                 360                 365             


Gln Trp Leu Gln Ser Ser Glu Gly Gly Ile Ala Gly Gly Ala Thr Asn 
    370                 375                 380                 


Ser Trp Asn Gly Ser Tyr Ala Thr Pro Pro Ala Gly Thr Pro Thr Phe 
385                 390                 395                 400 


Tyr Gly Met Ser Tyr Asp Glu Gln Pro Val Tyr His Asp Pro Pro Ser 
                405                 410                 415     


Asn Gln Trp Phe Gly Met Gln Ala Trp Ser Met Glu Arg Val Ala Glu 
            420                 425                 430         


Tyr Tyr Tyr Ala Thr Gly Asp Ala Arg Ala Lys Ala Val Leu Asp Lys 
        435                 440                 445             


Trp Val Pro Trp Ala Ile Ala Asn Thr Thr Ile Asn Ala Asp Gly Ser 
    450                 455                 460                 


Phe Gln Ile Pro Ser Asp Leu Glu Trp Ser Gly Gln Pro Asp Thr Trp 
465                 470                 475                 480 


Asn Ala Ser Ser Pro Gly Ala Asn Thr Asn Leu His Val Thr Val Thr 
                485                 490                 495     


Asn Tyr Gly Gln Asp Val Gly Val Ala Gly Ser Leu Ala Lys Thr Leu 
            500                 505                 510         


Thr Tyr Tyr Ala Ala Lys Ser Gly Asn Thr Thr Ala Lys Asp Thr Ala 
        515                 520                 525             


Lys Gly Leu Leu Asp Ala Leu Asn Asn Tyr Gln Asp Ser Lys Gly Ile 
    530                 535                 540                 


Ser Val Pro Glu Thr Arg Ala Asp Tyr Asn Arg Phe Asp Asp Gly Val 
545                 550                 555                 560 


Tyr Val Pro Pro Gly Trp Thr Gly Thr Met Pro Asn Gly Asp Val Ile 
                565                 570                 575     


Lys Ser Gly Ala Thr Phe Leu Asp Ile Arg Ser Phe Tyr Lys Asn Asp 
            580                 585                 590         


Pro Asp Trp Pro Lys Val Glu Ala Tyr Leu Asn Gly Gly Pro Ala Pro 
        595                 600                 605             


Thr Phe Thr Tyr His Arg Phe Trp Ala Gln Val Asp Ile Ala Thr Ala 
    610                 615                 620                 


Tyr Ala 
625     


<210>  3
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ancestral exoglucanase catalytic domain

<400>  3

Asp Asn Ala Tyr Asp Gln Arg Phe Leu Thr Met Tyr Asn Lys Ile Lys 
1               5                   10                  15      


Asp Pro Ala Asn Gly Tyr Phe Ser Pro Glu Gly Val Pro Tyr His Ser 
            20                  25                  30          


Val Glu Thr Leu Ile Val Glu Ala Pro Asp His Gly His Glu Thr Thr 
        35                  40                  45              


Ser Glu Ala Phe Ser Tyr Tyr Leu Trp Leu Glu Ala Met Tyr Gly Arg 
    50                  55                  60                  


Val Thr Gly Asp Trp Ser Pro Phe Asn Asn Ala Trp Asp Thr Met Glu 
65                  70                  75                  80  


Lys Tyr Ile Ile Pro Ser His Ala Asp Gln Pro Thr Asn Ser Ser Tyr 
                85                  90                  95      


Asn Pro Ser Lys Pro Ala Thr Tyr Ala Pro Glu His Pro Asp Pro Ser 
            100                 105                 110         


Gln Tyr Pro Ser Gln Leu Asp Ser Ser Val Pro Val Gly Gln Asp Pro 
        115                 120                 125             


Ile Ala Asn Glu Leu Lys Ser Thr Tyr Gly Thr Asn Asp Ile Tyr Gly 
    130                 135                 140                 


Met His Trp Leu Leu Asp Val Asp Asn Val Tyr Gly Phe Gly Asn Ser 
145                 150                 155                 160 


Pro Gly Arg Cys Glu Asp Gly Asp Ser Thr Thr Arg Pro Ala Tyr Ile 
                165                 170                 175     


Asn Thr Phe Gln Arg Gly Pro Gln Glu Ser Val Trp Glu Thr Val Pro 
            180                 185                 190         


Gln Pro Ser Cys Asp Thr Phe Lys Tyr Gly Gly Lys Asn Gly Tyr Leu 
        195                 200                 205             


Asp Leu Phe Thr Gly Asp Ser Ser Tyr Pro Ala Lys Gln Trp Lys Tyr 
    210                 215                 220                 


Thr Asn Ala Pro Asp Ala Asp Ala Arg Ala Val Gln Ala Ala Tyr Trp 
225                 230                 235                 240 


Ala His Glu Trp Ala Lys Glu Gln Gly Lys Ala Ser Glu Val Ala Ala 
                245                 250                 255     


Thr Val Ala Lys Ala Ala Lys Met Gly Asp Tyr Leu Arg Tyr Ser Met 
            260                 265                 270         


Phe Asp Lys Tyr Phe Lys Lys Ile Gly Asn Cys Val Gly Ala Ser Ser 
        275                 280                 285             


Cys Pro Ala Gly Thr Gly Lys Asp Ser Ala His Tyr Leu Leu Ser Trp 
    290                 295                 300                 


Tyr Tyr Ala Trp Gly Gly Ala Thr Asp Thr Ser Ala Gly Trp Ala Trp 
305                 310                 315                 320 


Arg Ile Gly Ser Ser His Ser His Ser Gly Tyr Gln Asn Pro Met Ala 
                325                 330                 335     


Ala Trp Ala Leu Ser Asn Val Ala Glu Leu Lys Pro Lys Ser Pro Thr 
            340                 345                 350         


Gly Ala Ser Asp Trp Ala Thr Ser Leu Lys Arg Gln Leu Glu Phe Tyr 
        355                 360                 365             


Gln Trp Leu Gln Ser Ser Glu Gly Gly Ile Ala Gly Gly Ala Thr Asn 
    370                 375                 380                 


Ser Trp Asn Gly Ser Tyr Ala Thr Pro Pro Ala Gly Thr Pro Thr Phe 
385                 390                 395                 400 


Tyr Gly Met Tyr Tyr Asp Glu Gln Pro Val Tyr His Asp Pro Pro Ser 
                405                 410                 415     


Asn Gln Trp Phe Gly Phe Gln Ala Trp Ser Met Glu Arg Val Ala Glu 
            420                 425                 430         


Tyr Tyr Tyr Ala Thr Gly Asp Ala Arg Ala Lys Ala Val Leu Asp Lys 
        435                 440                 445             


Trp Val Pro Trp Ala Ile Ala Asn Thr Thr Ile Asn Ala Asp Gly Ser 
    450                 455                 460                 


Phe Gln Ile Pro Ser Asp Leu Glu Trp Ser Gly Gln Pro Asp Thr Trp 
465                 470                 475                 480 


Asn Ala Ser Ser Pro Gly Ala Asn Thr Asn Leu His Val Thr Val Thr 
                485                 490                 495     


Asn Tyr Ser Gln Asp Val Gly Val Ala Gly Ser Leu Ala Lys Thr Leu 
            500                 505                 510         


Thr Tyr Tyr Ala Ala Lys Ser Gly Asn Thr Thr Ala Lys Ala Thr Ala 
        515                 520                 525             


Lys Gly Leu Leu Asp Ala Leu Asn Asn Tyr Gln Asp Ser Lys Gly Ile 
    530                 535                 540                 


Ala Val Pro Glu Thr Arg Ala Asp Tyr Asn Arg Phe Asp Asp Gly Val 
545                 550                 555                 560 


Tyr Val Pro Pro Gly Trp Thr Gly Thr Met Pro Asn Gly Asp Val Ile 
                565                 570                 575     


Asp Ser Gly Ser Thr Phe Leu Ser Ile Arg Ser Phe Tyr Lys Asn Asp 
            580                 585                 590         


Pro Asp Trp Pro Lys Val Glu Ala Tyr Leu Asn Gly Gly Pro Ala Pro 
        595                 600                 605             


Thr Phe Thr Tyr His Arg Phe Trp Ala Gln Val Asp Ile Ala Thr Ala 
    610                 615                 620                 


Phe Ala 
625     


<210>  4
<211>  626
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence for variants of the ancestral exoglucosidases


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (126)..(126)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (141)..(141)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (154)..(154)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (183)..(183)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (191)..(191)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (196)..(196)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (198)..(199)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (204)..(204)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (207)..(207)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (216)..(216)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (238)..(238)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (250)..(250)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (253)..(253)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (255)..(255)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (257)..(257)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (262)..(262)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (278)..(278)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (289)..(289)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (311)..(312)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (317)..(317)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (329)..(329)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (343)..(344)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (359)..(359)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (377)..(377)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (393)..(393)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (398)..(398)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (404)..(404)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (422)..(422)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (436)..(436)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (440)..(440)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (444)..(444)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (451)..(451)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (454)..(454)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (457)..(457)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (464)..(464)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (469)..(470)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (481)..(481)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (484)..(485)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (489)..(489)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (496)..(496)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (499)..(499)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (511)..(511)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (526)..(526)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (530)..(530)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (545)..(545)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (557)..(557)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (559)..(559)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (564)..(564)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (577)..(577)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (580)..(580)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (584)..(584)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (588)..(588)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (591)..(591)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (601)..(601)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (603)..(604)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (625)..(625)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Asp Asn Ala Tyr Xaa Gln Arg Phe Leu Xaa Met Tyr Asn Lys Ile Lys 
1               5                   10                  15      


Asp Pro Ala Asn Gly Tyr Phe Ser Pro Glu Gly Xaa Pro Tyr His Ser 
            20                  25                  30          


Val Glu Thr Leu Ile Val Glu Ala Pro Asp Xaa Gly His Glu Thr Thr 
        35                  40                  45              


Ser Glu Ala Phe Ser Tyr Tyr Leu Trp Leu Glu Ala Met Tyr Gly Arg 
    50                  55                  60                  


Xaa Thr Gly Asp Trp Ser Xaa Phe Asn Asn Ala Trp Asp Thr Met Glu 
65                  70                  75                  80  


Lys Tyr Ile Ile Pro Ser His Ala Asp Gln Pro Thr Xaa Ser Ser Tyr 
                85                  90                  95      


Asn Pro Xaa Lys Pro Ala Thr Tyr Ala Pro Glu His Pro Asp Pro Ser 
            100                 105                 110         


Gln Tyr Pro Ser Gln Leu Asp Ser Ser Xaa Pro Val Gly Xaa Asp Pro 
        115                 120                 125             


Ile Xaa Asn Glu Leu Lys Ser Thr Tyr Gly Thr Asn Xaa Ile Tyr Gly 
    130                 135                 140                 


Met His Trp Leu Leu Asp Val Asp Asn Xaa Tyr Gly Phe Gly Asn Ser 
145                 150                 155                 160 


Pro Gly Arg Cys Glu Asp Gly Asp Ser Thr Thr Arg Pro Ala Tyr Ile 
                165                 170                 175     


Asn Thr Phe Gln Arg Gly Xaa Gln Glu Ser Val Trp Glu Thr Xaa Pro 
            180                 185                 190         


Gln Pro Ser Xaa Asp Xaa Xaa Lys Tyr Gly Gly Xaa Asn Gly Xaa Leu 
        195                 200                 205             


Asp Leu Phe Thr Gly Asp Ser Xaa Tyr Pro Ala Lys Gln Trp Lys Tyr 
    210                 215                 220                 


Thr Asn Ala Pro Asp Ala Asp Ala Arg Ala Val Gln Ala Xaa Tyr Trp 
225                 230                 235                 240 


Ala His Glu Trp Ala Lys Glu Gln Gly Xaa Ala Ser Xaa Val Xaa Ala 
                245                 250                 255     


Xaa Val Ala Lys Ala Xaa Lys Met Gly Asp Tyr Leu Arg Tyr Ser Met 
            260                 265                 270         


Phe Asp Lys Tyr Phe Xaa Lys Ile Gly Asn Cys Val Gly Ala Ser Ser 
        275                 280                 285             


Xaa Pro Ala Gly Thr Gly Lys Asp Ser Ala His Tyr Leu Leu Ser Trp 
    290                 295                 300                 


Tyr Tyr Ala Trp Gly Gly Xaa Xaa Asp Thr Ser Ala Xaa Trp Ala Trp 
305                 310                 315                 320 


Arg Ile Gly Ser Ser His Ser His Xaa Gly Tyr Gln Asn Pro Met Ala 
                325                 330                 335     


Ala Trp Ala Leu Ser Asn Xaa Xaa Glu Leu Lys Pro Lys Ser Pro Thr 
            340                 345                 350         


Gly Ala Ser Asp Trp Ala Xaa Ser Leu Lys Arg Gln Leu Glu Phe Tyr 
        355                 360                 365             


Gln Trp Leu Gln Ser Ser Glu Gly Xaa Ile Ala Gly Gly Ala Thr Asn 
    370                 375                 380                 


Ser Trp Asn Gly Ser Tyr Ala Thr Xaa Pro Ala Gly Thr Xaa Thr Phe 
385                 390                 395                 400 


Tyr Gly Met Xaa Tyr Asp Glu Gln Pro Val Tyr His Asp Pro Pro Ser 
                405                 410                 415     


Asn Gln Trp Phe Gly Xaa Gln Ala Trp Ser Met Glu Arg Val Ala Glu 
            420                 425                 430         


Tyr Tyr Tyr Xaa Thr Gly Asp Xaa Arg Ala Lys Xaa Val Leu Asp Lys 
        435                 440                 445             


Trp Val Xaa Trp Ala Xaa Ala Asn Xaa Thr Ile Asn Ala Asp Gly Xaa 
    450                 455                 460                 


Phe Gln Ile Pro Xaa Xaa Leu Glu Trp Ser Gly Gln Pro Asp Thr Trp 
465                 470                 475                 480 


Xaa Ala Ser Xaa Xaa Gly Ala Asn Xaa Asn Leu His Val Thr Val Xaa 
                485                 490                 495     


Asn Tyr Xaa Gln Asp Val Gly Val Ala Gly Ser Leu Ala Lys Xaa Leu 
            500                 505                 510         


Thr Tyr Tyr Ala Ala Lys Ser Gly Asn Thr Thr Ala Lys Xaa Thr Ala 
        515                 520                 525             


Lys Xaa Leu Leu Asp Ala Leu Asn Asn Tyr Gln Asp Ser Lys Gly Ile 
    530                 535                 540                 


Xaa Val Pro Glu Thr Arg Ala Asp Tyr Asn Arg Phe Xaa Asp Xaa Val 
545                 550                 555                 560 


Tyr Val Pro Xaa Gly Trp Thr Gly Thr Met Pro Asn Gly Asp Val Ile 
                565                 570                 575     


Xaa Ser Gly Xaa Thr Phe Leu Xaa Ile Arg Ser Xaa Tyr Lys Xaa Asp 
            580                 585                 590         


Pro Asp Trp Pro Lys Val Glu Ala Xaa Leu Xaa Xaa Gly Pro Ala Pro 
        595                 600                 605             


Thr Phe Thr Tyr His Arg Phe Trp Ala Gln Val Asp Ile Ala Thr Ala 
    610                 615                 620                 


Xaa Ala 
625     


<210>  5
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  5

Ala Cys Ser Val Asp Tyr Lys Thr Asn Asp Trp Gly Ser Gly Phe Thr 
1               5                   10                  15      


Ala Glu Val Thr Ile Thr Asn Arg Gly Thr Asp Pro Ile Asp Gly Trp 
            20                  25                  30          


Thr Leu Gly Tyr Thr Phe Pro Gly Asn Gln Lys Ile Thr Asn Gly Trp 
        35                  40                  45              


Asn Gly Thr Trp Ser Gln Ser Gly Ala Asn Val Thr Val Lys Asn Ala 
    50                  55                  60                  


Ser Trp Asn Gly Asn Ile Ala Ala Gly Ala Thr Val Ser Ile Gly Phe 
65                  70                  75                  80  


Gln Gly Thr Tyr Ser Gly Thr Asn Ala Ala Pro Thr Ser Phe Thr Val 
                85                  90                  95      


Asn Gly Val Thr Cys Ala Arg Ser 
            100                 


<210>  6
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ancestral beta glucosidase

<400>  6

Thr Asp Asn Ile Lys Glu Leu Val Asn Glu Met Thr Leu Glu Glu Lys 
1               5                   10                  15      


Ala Ser Leu Cys Ser Gly Ser Asp Phe Trp His Thr Gln Ser Ile Glu 
            20                  25                  30          


Arg Leu Gly Ile Pro Ser Ile Met Val Thr Asp Gly Pro His Gly Leu 
        35                  40                  45              


Arg Lys Gln Ala Ala Gly Ala Asp His Leu Gly Leu Asn Glu Ser Val 
    50                  55                  60                  


Pro Ala Thr Cys Phe Pro Thr Ala Ala Ala Leu Ala Ser Ser Trp Asp 
65                  70                  75                  80  


Pro Glu Leu Leu His Glu Val Gly Glu Ala Leu Gly Glu Glu Cys Arg 
                85                  90                  95      


Ala Glu Asn Val Ser Val Leu Leu Gly Pro Gly Val Asn Ile Lys Arg 
            100                 105                 110         


Ser Pro Leu Cys Gly Arg Asn Phe Glu Tyr Phe Ser Glu Asp Pro Tyr 
        115                 120                 125             


Leu Ala Gly Glu Met Ala Ala Ala Trp Ile Ser Gly Val Gln Ser Lys 
    130                 135                 140                 


Gly Val Gly Thr Ser Leu Lys His Phe Ala Ala Asn Asn Gln Glu His 
145                 150                 155                 160 


Arg Arg Met Thr Val Asp Ala Val Val Asp Glu Arg Thr Leu Arg Glu 
                165                 170                 175     


Ile Tyr Leu Ala Ala Phe Glu His Ala Val Lys Gln Ala Gln Pro Trp 
            180                 185                 190         


Thr Val Met Cys Ser Tyr Asn Arg Ile Asn Gly Val Tyr Ser Ser Glu 
        195                 200                 205             


Asn Arg Trp Leu Leu Thr Glu Val Leu Arg Asp Glu Trp Gly Phe Glu 
    210                 215                 220                 


Gly Leu Val Val Ser Asp Trp Gly Ala Val Asn Asp Arg Val Lys Ala 
225                 230                 235                 240 


Leu Lys Ala Gly Leu Asp Leu Glu Met Pro Ser Ser Gly Gly Leu Asn 
                245                 250                 255     


Asp Lys Gln Ile Val Glu Ala Val Arg Ser Gly Glu Leu Asp Glu Ala 
            260                 265                 270         


Val Leu Asp Arg Ala Ala Glu Arg Val Leu Thr Leu Ile Ala Arg Thr 
        275                 280                 285             


Ala Ala Ala Arg Thr Glu Asn His Ser Tyr Asp Val Glu Ala His His 
    290                 295                 300                 


Ala Leu Ala Arg Arg Ala Ala Ala Glu Ser Ala Val Leu Leu Lys Asn 
305                 310                 315                 320 


Asp Asp Gly Ile Leu Pro Leu Thr Ala Glu Ala Lys Ile Ala Val Ile 
                325                 330                 335     


Gly Glu Phe Ala Lys Thr Pro Arg Tyr Gln Gly Ala Gly Ser Ser Gln 
            340                 345                 350         


Ile Asn Pro Thr Lys Leu Asp Asn Ala Leu Asp Glu Leu Arg Glu Arg 
        355                 360                 365             


Gly Gly Asp Asp Val Thr Tyr Ala Pro Gly Tyr Glu Leu Asp Gly Asp 
    370                 375                 380                 


Arg Thr Asp Ala Ala Leu Leu Glu Glu Ala Val Glu Val Ala Lys Asn 
385                 390                 395                 400 


Ala Asp Val Val Val Val Phe Ala Gly Leu Pro Asp Ser Tyr Glu Ser 
                405                 410                 415     


Glu Gly Phe Asp Arg Thr His Leu Asn Leu Pro Glu Asn His Asn Ala 
            420                 425                 430         


Leu Ile Glu Ala Val Ala Glu Val Asn Pro Asn Val Val Val Val Leu 
        435                 440                 445             


Ser Asn Gly Ser Pro Val Thr Met Pro Trp Arg Asp Arg Val Lys Ala 
    450                 455                 460                 


Ile Leu Glu Ser Tyr Leu Gly Gly Gln Ala Gly Gly Ser Ala Ile Ala 
465                 470                 475                 480 


Asp Ile Leu Thr Gly Glu Val Asn Pro Ser Gly Arg Leu Ala Glu Thr 
                485                 490                 495     


Phe Pro Leu Arg Leu Glu Asp Asn Pro Ser Tyr Leu Asn Phe Pro Gly 
            500                 505                 510         


Glu Pro Gln His Val Glu Tyr Arg Glu Ser Ile Phe Val Gly Tyr Arg 
        515                 520                 525             


Tyr Tyr Asp Thr Ala Glu Arg Asp Val Ala Tyr Pro Phe Gly Tyr Gly 
    530                 535                 540                 


Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asp Leu Lys Val Ser Lys Ala 
545                 550                 555                 560 


Ala Asp Asp Asn Glu Thr Val Glu Val Ser Val Thr Val Thr Asn Thr 
                565                 570                 575     


Gly Asp Arg Ala Gly Ser Glu Val Val Gln Val Tyr Val Gly Asp Ala 
            580                 585                 590         


Glu Ser Thr Val Phe Arg Pro Val Gln Glu Leu Lys Gly Phe Ala Lys 
        595                 600                 605             


Val Phe Leu Glu Pro Gly Glu Ser Arg Glu Val Thr Ile Asp Leu Asp 
    610                 615                 620                 


Arg Arg Ala Phe Ser Tyr Trp Asn Val Lys Ile Asn Asp Trp Thr Val 
625                 630                 635                 640 


Glu Ser Gly Asp Phe Glu Ile Arg Val Gly Ser Ser Ser Arg Asp Ile 
                645                 650                 655     


Arg Leu Thr Ala Thr Val Thr Leu Asn Ser Asn Thr Pro Leu Pro Gln 
            660                 665                 670         


Thr Phe Thr Val Asn Thr Thr Ile Gly Asp Ile Met Ala His Pro Ala 
        675                 680                 685             


Gly Arg Ala Leu Leu Gly Ala Leu Val Gln Ala Val Ala Ala Gly Ser 
    690                 695                 700                 


Ala Ala Lys Asp Ser Val Ser Arg Met Met Met Ala Met Leu Gln Asp 
705                 710                 715                 720 


Met Pro Leu Arg Ser Leu Pro Met Phe Thr Gly Gly Ala Ile Thr Pro 
                725                 730                 735     


Glu Met Leu Glu Glu Leu Val Glu Met Leu Asn Gly 
            740                 745             


<210>  7
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ancestral beta glucosidase

<400>  7

Thr Asp Asn Ile Lys Glu Leu Val Asn Gln Met Thr Leu Glu Glu Lys 
1               5                   10                  15      


Ala Ser Leu Cys Ser Gly Lys Asp Phe Trp His Thr Gln Ser Ile Glu 
            20                  25                  30          


Arg Leu Gly Ile Pro Ser Ile Met Val Thr Asp Gly Pro His Gly Leu 
        35                  40                  45              


Arg Lys Gln Ala Ala Glu Ala Asp His Leu Gly Leu Asn Glu Ser Val 
    50                  55                  60                  


Pro Ala Thr Cys Phe Pro Thr Ala Ala Ala Leu Ala Ser Ser Trp Asp 
65                  70                  75                  80  


Pro Glu Leu Leu His Glu Val Gly Glu Ala Leu Gly Glu Glu Cys Arg 
                85                  90                  95      


Ala Glu Asn Val Ser Val Leu Leu Gly Pro Gly Val Asn Ile Lys Arg 
            100                 105                 110         


Ser Pro Leu Cys Gly Arg Asn Phe Glu Tyr Phe Ser Glu Asp Pro Tyr 
        115                 120                 125             


Leu Ala Gly Glu Met Ala Ala Ala Trp Ile Ser Gly Val Gln Ser Lys 
    130                 135                 140                 


Gly Val Gly Thr Ser Leu Lys His Phe Ala Ala Asn Asn Gln Glu His 
145                 150                 155                 160 


Arg Arg Met Thr Val Asp Ala Val Val Asp Glu Arg Thr Leu Arg Glu 
                165                 170                 175     


Ile Tyr Leu Ala Ala Phe Glu Asn Ala Val Lys Gln Ala Gln Pro Trp 
            180                 185                 190         


Thr Val Met Cys Ser Tyr Asn Arg Ile Asn Gly Val Tyr Ser Ser Glu 
        195                 200                 205             


Asn Lys Trp Leu Leu Thr Glu Val Leu Arg Asp Glu Trp Gly Phe Glu 
    210                 215                 220                 


Gly Leu Val Val Ser Asp Trp Gly Ala Val Asn Asp Arg Val Lys Gly 
225                 230                 235                 240 


Leu Lys Ala Gly Leu Asp Leu Glu Met Pro Ser Ser Gly Gly Leu Asn 
                245                 250                 255     


Asp Lys Gln Ile Val Glu Ala Val Arg Asn Gly Glu Leu Asp Glu Ala 
            260                 265                 270         


Val Leu Asp Arg Ala Ala Glu Arg Ile Leu Thr Leu Ile Ala Arg Ala 
        275                 280                 285             


Ala Ala Ala Arg Lys Gln Asn His Thr Tyr Asp Val Glu Ala His His 
    290                 295                 300                 


Ala Leu Ala Arg Arg Ile Ala Ala Glu Ser Ala Val Leu Leu Lys Asn 
305                 310                 315                 320 


Asp Asp Gly Ile Leu Pro Leu Lys Lys Glu Ala Lys Ile Ala Val Ile 
                325                 330                 335     


Gly Glu Phe Ala Lys Thr Pro Arg Tyr Gln Gly Ala Gly Ser Ser Gln 
            340                 345                 350         


Ile Asn Pro Thr Lys Leu Asp Asn Ala Leu Asp Glu Leu Arg Glu Arg 
        355                 360                 365             


Gly Gly Ala Asp Val Thr Tyr Ala Pro Gly Tyr Glu Leu Asp Gly Asp 
    370                 375                 380                 


Arg Thr Asp Ala Ala Leu Leu Glu Glu Ala Val Glu Val Ala Lys Asn 
385                 390                 395                 400 


Ala Asp Val Val Val Val Phe Ala Gly Leu Pro Asp Ser Tyr Glu Ser 
                405                 410                 415     


Glu Gly Phe Asp Arg Thr His Leu Asn Leu Pro Glu Asn His Asn Ala 
            420                 425                 430         


Leu Ile Glu Ala Val Ala Glu Val Asn Pro Asn Val Val Val Val Leu 
        435                 440                 445             


Ser Asn Gly Ser Pro Val Thr Met Pro Trp Arg Asp Lys Val Lys Ala 
    450                 455                 460                 


Ile Leu Glu Ser Tyr Leu Gly Gly Gln Ala Gly Gly Ser Ala Ile Ala 
465                 470                 475                 480 


Asp Ile Leu Thr Gly Glu Val Asn Pro Ser Gly Arg Leu Ala Glu Thr 
                485                 490                 495     


Phe Pro Leu Arg Leu Glu Asp Asn Pro Ser Tyr Leu Asn Phe Pro Gly 
            500                 505                 510         


Glu Pro Gln His Val Glu Tyr Arg Glu Ser Ile Phe Val Gly Tyr Arg 
        515                 520                 525             


Tyr Tyr Asp Thr Ala Glu Lys Asp Val Ala Phe Pro Phe Gly Tyr Gly 
    530                 535                 540                 


Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asp Leu Lys Ile Ser Lys Ala 
545                 550                 555                 560 


Ala Asp Asp Asn Glu Thr Val Glu Val Ser Val Thr Val Thr Asn Thr 
                565                 570                 575     


Gly Asp Arg Ala Gly Ser Glu Val Val Gln Val Tyr Val Gly Asp Ala 
            580                 585                 590         


Glu Ser Thr Val Phe Arg Pro Val Gln Glu Leu Lys Gly Phe Ala Lys 
        595                 600                 605             


Val Phe Leu Glu Pro Gly Glu Ser Arg Glu Val Thr Ile Thr Leu Asp 
    610                 615                 620                 


Arg Arg Ala Phe Ser Tyr Tyr Asn Val Lys Ile Asn Asp Trp Thr Val 
625                 630                 635                 640 


Glu Ser Gly Asp Phe Glu Ile Arg Val Gly Ser Ser Ser Arg Asp Ile 
                645                 650                 655     


Arg Leu Lys Ala Thr Val Thr Leu Asn Ser Thr Thr Pro Leu Pro Ala 
            660                 665                 670         


Thr Phe Thr Val Asn Thr Thr Ile Gly Asp Ile Met Ala Ser Pro Ala 
        675                 680                 685             


Gly Lys Ala Leu Leu Gly Ala Leu Val Gln Ala Val Ser Ala Gly Ser 
    690                 695                 700                 


Gly Ala Lys Asp Ser Val Ser Arg Met Met Met Ala Met Leu Gln Asp 
705                 710                 715                 720 


Met Pro Leu Arg Ser Leu Ala Met Phe Thr Gly Gly Ala Ile Thr Pro 
                725                 730                 735     


Glu Met Leu Glu Glu Leu Val Glu Met Leu Asn Gly 
            740                 745             


<210>  8
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ancestral beta glucosidase

<400>  8

Met Met Asn Ile Lys Glu Ile Ile Asn Gln Met Thr Leu Glu Glu Lys 
1               5                   10                  15      


Ala Ser Leu Cys Ser Gly Lys Asp Phe Trp His Thr Lys Ser Ile Glu 
            20                  25                  30          


Arg Leu Gly Ile Pro Ser Ile Met Met Thr Asp Gly Pro His Gly Leu 
        35                  40                  45              


Arg Lys Gln Lys Ala Asp Ala Asp His Leu Gly Leu Asn Glu Ser Val 
    50                  55                  60                  


Pro Ala Thr Cys Phe Pro Thr Ala Ala Ala Leu Ala Ser Ser Trp Asp 
65                  70                  75                  80  


Pro Asp Leu Leu Glu Glu Val Gly Lys Ala Leu Gly Glu Glu Cys Gln 
                85                  90                  95      


Ala Glu Asn Val Ser Val Leu Leu Gly Pro Gly Val Asn Ile Lys Arg 
            100                 105                 110         


Ser Pro Leu Cys Gly Arg Asn Phe Glu Tyr Phe Ser Glu Asp Pro Tyr 
        115                 120                 125             


Leu Ala Gly Glu Met Ala Ala Ser Trp Ile Lys Gly Val Gln Ser Gln 
    130                 135                 140                 


Gly Val Gly Thr Ser Leu Lys His Phe Ala Ala Asn Asn Gln Glu His 
145                 150                 155                 160 


Arg Arg Met Thr Val Asp Ala Val Val Asp Glu Arg Thr Leu Arg Glu 
                165                 170                 175     


Ile Tyr Leu Ala Ala Phe Glu Asn Ala Val Lys Gln Ala Gln Pro Trp 
            180                 185                 190         


Thr Val Met Cys Ser Tyr Asn Lys Ile Asn Gly Val Tyr Ala Ser Glu 
        195                 200                 205             


Asn Lys Arg Leu Leu Thr Glu Ile Leu Arg Asp Glu Trp Gly Phe Glu 
    210                 215                 220                 


Gly Leu Val Val Ser Asp Trp Gly Ala Val Asn Asp Arg Val Lys Gly 
225                 230                 235                 240 


Leu Lys Ala Gly Leu Asp Leu Glu Met Pro Ser Ser Gly Gly Ile Asn 
                245                 250                 255     


Asp Lys Gln Ile Val Glu Ala Val Lys Asn Gly Glu Leu Asp Glu Ala 
            260                 265                 270         


Val Leu Asp Arg Ala Val Glu Arg Ile Leu Asn Leu Ile Phe Lys Ala 
        275                 280                 285             


Ala Ala Ala Arg Lys Gln Asn His Thr Tyr Asp Val Glu Ala His His 
    290                 295                 300                 


Ala Leu Ala Arg Lys Ile Ala Ala Glu Ser Met Val Leu Leu Lys Asn 
305                 310                 315                 320 


Asp Asp Gly Ile Leu Pro Leu Lys Lys Glu Ala Lys Ile Ala Val Ile 
                325                 330                 335     


Gly Glu Phe Ala Lys Thr Pro Arg Tyr Gln Gly Ala Gly Ser Ser His 
            340                 345                 350         


Ile Asn Pro Thr Lys Leu Asp Asn Ala Leu Asp Glu Leu Lys Glu Leu 
        355                 360                 365             


Gly Gly Ala Asp Val Thr Tyr Ala Gln Gly Tyr Glu Leu Asp Gly Asp 
    370                 375                 380                 


Arg Thr Asp Ala Ala Leu Ile Glu Glu Ala Val Glu Leu Ala Lys Asn 
385                 390                 395                 400 


Ala Asp Val Val Val Ile Phe Ala Gly Leu Pro Asp Ser Tyr Glu Ser 
                405                 410                 415     


Glu Gly Phe Asp Arg Thr His Met Asn Met Pro Glu Asn His Asn Glu 
            420                 425                 430         


Leu Ile Glu Ala Val Ala Lys Val Asn Pro Asn Val Val Val Val Leu 
        435                 440                 445             


Ser Asn Gly Ser Pro Val Glu Met Pro Trp Ile Asp Lys Val Lys Gly 
    450                 455                 460                 


Ile Leu Glu Ser Tyr Leu Gly Gly Gln Ala Gly Gly Ser Ala Ile Ala 
465                 470                 475                 480 


Asp Ile Leu Thr Gly Glu Val Asn Pro Ser Gly Lys Leu Ala Glu Thr 
                485                 490                 495     


Phe Pro Leu Arg Leu Glu Asp Asn Pro Ser Tyr Leu Asn Phe Pro Gly 
            500                 505                 510         


Glu Pro Asp Arg Val Glu Tyr Arg Glu Ser Ile Phe Val Gly Tyr Arg 
        515                 520                 525             


Tyr Tyr Asp Thr Ala Asn Lys Asp Val Leu Phe Pro Phe Gly Tyr Gly 
    530                 535                 540                 


Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asp Leu Lys Ile Ser Lys Glu 
545                 550                 555                 560 


Ile Asn Asp Thr Glu Thr Val Glu Val Ser Val Lys Val Lys Asn Thr 
                565                 570                 575     


Gly Asp Val Ala Gly Ser Glu Val Val Gln Val Tyr Val Ser Asp Lys 
            580                 585                 590         


Glu Ser Thr Val Phe Arg Pro Val Lys Glu Leu Lys Gly Phe Glu Lys 
        595                 600                 605             


Val Phe Leu Glu Pro Gly Glu Ser Lys Glu Val Thr Ile Thr Leu Asp 
    610                 615                 620                 


Lys Arg Ala Phe Ala Tyr Tyr Asn Val Lys Ile Asn Asp Trp His Val 
625                 630                 635                 640 


Glu Ser Gly Glu Phe Glu Ile Leu Val Gly Ser Ser Ser Arg Asp Ile 
                645                 650                 655     


Arg Leu Lys Ala Thr Val Thr Val Asn Ser Thr Thr Pro Leu Pro Ala 
            660                 665                 670         


Thr Phe Thr Val Asn Thr Thr Ile Gly Asp Val Met Ser Thr Pro Ala 
        675                 680                 685             


Gly Lys Ala Leu Leu Asn Ala Leu Ile Gln Lys Val Ser Val Gly Ser 
    690                 695                 700                 


Gly Ala Lys Asp Ser Glu Ser Asp Met Met Met Ala Met Val Gln Asp 
705                 710                 715                 720 


Met Pro Leu Arg Ser Leu Val Thr Phe Thr Gly Gly Ala Ile Thr Ala 
                725                 730                 735     


Glu Met Leu Glu Glu Leu Ile Glu Met Leu Asn Gly 
            740                 745             


<210>  9
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linking domain

<400>  9

Pro Arg Phe Val Lys Pro Val Glu Tyr Val Leu Pro Gln Pro Asp Val 
1               5                   10                  15      


Arg Val Asn Gln Val Gly Tyr Leu Pro Phe Ala Lys Lys Tyr Ala Thr 
            20                  25                  30          


Val Val Ser Ser Ser Thr Ser Pro Leu Lys Arg Ser 
        35                  40                  


<210>  10
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus sequence of the ancestral beta glucosidases


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (42)..(50)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (136)..(136)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (139)..(139)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (144)..(144)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (184)..(184)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (200)..(200)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (206)..(206)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (210)..(211)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (216)..(216)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (240)..(240)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (255)..(255)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (265)..(266)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (278)..(278)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (281)..(281)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (283)..(283)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (286)..(288)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (293)..(294)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (297)..(297)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (309)..(310)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (315)..(315)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (328)..(329)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (352)..(352)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (366)..(366)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (368)..(368)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (371)..(371)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (377)..(377)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (391)..(391)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (397)..(397)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (406)..(406)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (424)..(424)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (426)..(426)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (432)..(432)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (439)..(439)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (455)..(455)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (459)..(459)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (461)..(461)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (464)..(464)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (492)..(492)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (515)..(516)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (534)..(535)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (538)..(539)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (557)..(557)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (560)..(562)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (564)..(564)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (572)..(572)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (574)..(574)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (579)..(579)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (590)..(590)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (592)..(592)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (601)..(601)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (607)..(607)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (617)..(617)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (622)..(622)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (625)..(625)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (629)..(629)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (631)..(631)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (639)..(639)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (644)..(644)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (648)..(648)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (659)..(659)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (664)..(664)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (667)..(667)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (672)..(672)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (683)..(683)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (685)..(686)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (694)..(694)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (697)..(697)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (699)..(699)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (701)..(702)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (705)..(705)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (710)..(710)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (712)..(712)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (718)..(718)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (727)..(728)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (736)..(736)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (743)..(743)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Xaa Xaa Asn Ile Lys Glu Xaa Xaa Asn Xaa Met Thr Leu Glu Glu Lys 
1               5                   10                  15      


Ala Ser Leu Cys Ser Gly Xaa Asp Phe Trp His Thr Xaa Ser Ile Glu 
            20                  25                  30          


Arg Leu Gly Ile Pro Ser Ile Met Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Gln Xaa Ala Xaa Ala Asp His Leu Gly Leu Asn Glu Ser Val 
    50                  55                  60                  


Pro Ala Thr Cys Phe Pro Thr Ala Ala Ala Leu Ala Ser Ser Trp Asp 
65                  70                  75                  80  


Pro Xaa Leu Leu Xaa Glu Val Gly Xaa Ala Leu Gly Glu Glu Cys Xaa 
                85                  90                  95      


Ala Glu Asn Val Ser Val Leu Leu Gly Pro Gly Val Asn Ile Lys Arg 
            100                 105                 110         


Ser Pro Leu Cys Gly Arg Asn Phe Glu Tyr Phe Ser Glu Asp Pro Tyr 
        115                 120                 125             


Leu Ala Gly Glu Met Ala Ala Xaa Trp Ile Xaa Gly Val Gln Ser Xaa 
    130                 135                 140                 


Gly Val Gly Thr Ser Leu Lys His Phe Ala Ala Asn Asn Gln Glu His 
145                 150                 155                 160 


Arg Arg Met Thr Val Asp Ala Val Val Asp Glu Arg Thr Leu Arg Glu 
                165                 170                 175     


Ile Tyr Leu Ala Ala Phe Glu Xaa Ala Val Lys Gln Ala Gln Pro Trp 
            180                 185                 190         


Thr Val Met Cys Ser Tyr Asn Xaa Ile Asn Gly Val Tyr Xaa Ser Glu 
        195                 200                 205             


Asn Xaa Xaa Leu Leu Thr Glu Xaa Leu Arg Asp Glu Trp Gly Phe Glu 
    210                 215                 220                 


Gly Leu Val Val Ser Asp Trp Gly Ala Val Asn Asp Arg Val Lys Xaa 
225                 230                 235                 240 


Leu Lys Ala Gly Leu Asp Leu Glu Met Pro Ser Ser Gly Gly Xaa Asn 
                245                 250                 255     


Asp Lys Gln Ile Val Glu Ala Val Xaa Xaa Gly Glu Leu Asp Glu Ala 
            260                 265                 270         


Val Leu Asp Arg Ala Xaa Glu Arg Xaa Leu Xaa Leu Ile Xaa Xaa Xaa 
        275                 280                 285             


Ala Ala Ala Arg Xaa Xaa Asn His Xaa Tyr Asp Val Glu Ala His His 
    290                 295                 300                 


Ala Leu Ala Arg Xaa Xaa Ala Ala Glu Ser Xaa Val Leu Leu Lys Asn 
305                 310                 315                 320 


Asp Asp Gly Ile Leu Pro Leu Xaa Xaa Glu Ala Lys Ile Ala Val Ile 
                325                 330                 335     


Gly Glu Phe Ala Lys Thr Pro Arg Tyr Gln Gly Ala Gly Ser Ser Xaa 
            340                 345                 350         


Ile Asn Pro Thr Lys Leu Asp Asn Ala Leu Asp Glu Leu Xaa Glu Xaa 
        355                 360                 365             


Gly Gly Xaa Asp Val Thr Tyr Ala Xaa Gly Tyr Glu Leu Asp Gly Asp 
    370                 375                 380                 


Arg Thr Asp Ala Ala Leu Xaa Glu Glu Ala Val Glu Xaa Ala Lys Asn 
385                 390                 395                 400 


Ala Asp Val Val Val Xaa Phe Ala Gly Leu Pro Asp Ser Tyr Glu Ser 
                405                 410                 415     


Glu Gly Phe Asp Arg Thr His Xaa Asn Xaa Pro Glu Asn His Asn Xaa 
            420                 425                 430         


Leu Ile Glu Ala Val Ala Xaa Val Asn Pro Asn Val Val Val Val Leu 
        435                 440                 445             


Ser Asn Gly Ser Pro Val Xaa Met Pro Trp Xaa Asp Xaa Val Lys Xaa 
    450                 455                 460                 


Ile Leu Glu Ser Tyr Leu Gly Gly Gln Ala Gly Gly Ser Ala Ile Ala 
465                 470                 475                 480 


Asp Ile Leu Thr Gly Glu Val Asn Pro Ser Gly Xaa Leu Ala Glu Thr 
                485                 490                 495     


Phe Pro Leu Arg Leu Glu Asp Asn Pro Ser Tyr Leu Asn Phe Pro Gly 
            500                 505                 510         


Glu Pro Xaa Xaa Val Glu Tyr Arg Glu Ser Ile Phe Val Gly Tyr Arg 
        515                 520                 525             


Tyr Tyr Asp Thr Ala Xaa Xaa Asp Val Xaa Xaa Pro Phe Gly Tyr Gly 
    530                 535                 540                 


Leu Ser Tyr Thr Thr Phe Glu Tyr Ser Asp Leu Lys Xaa Ser Lys Xaa 
545                 550                 555                 560 


Xaa Xaa Asp Xaa Glu Thr Val Glu Val Ser Val Xaa Val Xaa Asn Thr 
                565                 570                 575     


Gly Asp Xaa Ala Gly Ser Glu Val Val Gln Val Tyr Val Xaa Asp Xaa 
            580                 585                 590         


Glu Ser Thr Val Phe Arg Pro Val Xaa Glu Leu Lys Gly Phe Xaa Lys 
        595                 600                 605             


Val Phe Leu Glu Pro Gly Glu Ser Xaa Glu Val Thr Ile Xaa Leu Asp 
    610                 615                 620                 


Xaa Arg Ala Phe Xaa Tyr Xaa Asn Val Lys Ile Asn Asp Trp Xaa Val 
625                 630                 635                 640 


Glu Ser Gly Xaa Phe Glu Ile Xaa Val Gly Ser Ser Ser Arg Asp Ile 
                645                 650                 655     


Arg Leu Xaa Ala Thr Val Thr Xaa Asn Ser Xaa Thr Pro Leu Pro Xaa 
            660                 665                 670         


Thr Phe Thr Val Asn Thr Thr Ile Gly Asp Xaa Met Xaa Xaa Pro Ala 
        675                 680                 685             


Gly Lys Ala Leu Leu Xaa Ala Leu Xaa Gln Xaa Val Xaa Xaa Gly Ser 
    690                 695                 700                 


Xaa Ala Lys Asp Ser Xaa Ser Xaa Met Met Met Ala Met Xaa Gln Asp 
705                 710                 715                 720 


Met Pro Leu Arg Ser Leu Xaa Xaa Phe Thr Gly Gly Ala Ile Thr Xaa 
                725                 730                 735     


Glu Met Leu Glu Glu Leu Xaa Glu Met Leu Asn Gly 
            740                 745             


<210>  11
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ancestral endocellulase

<400>  11

Thr Pro Val Glu Thr His Gly Gln Leu Ser Val Lys Gly Gly Gln Leu 
1               5                   10                  15      


Val Asp Glu Asn Gly Lys Pro Val Gln Leu Arg Gly Met Ser Ser His 
            20                  25                  30          


Gly Leu Gln Trp Phe Gly Asp Phe Val Asn Lys Asp Ser Met Lys Trp 
        35                  40                  45              


Leu Arg Asp Asp Trp Gly Ile Asn Val Phe Arg Val Ala Met Tyr Thr 
    50                  55                  60                  


Ala Glu Gly Gly Tyr Ile Thr Asn Pro Ser Val Lys Asn Lys Val Lys 
65                  70                  75                  80  


Glu Ala Val Glu Ala Ala Ile Asp Leu Gly Met Tyr Val Ile Ile Asp 
                85                  90                  95      


Trp His Ile Leu Ser Asp Asn Asp Pro Asn Thr Tyr Lys Glu Gln Ala 
            100                 105                 110         


Lys Ala Phe Phe Gln Glu Met Ala Ala Lys Tyr Gly Asn Tyr Pro Asn 
        115                 120                 125             


Val Ile Tyr Glu Ile Cys Asn Glu Pro Asn Gly Gly Val Thr Trp Ser 
    130                 135                 140                 


Asn Gln Ile Lys Pro Tyr Ala Glu Glu Val Ile Pro Ala Ile Arg Ala 
145                 150                 155                 160 


Asn Asp Pro Asp Asn Ile Ile Ile Val Gly Thr Pro Thr Trp Ser Gln 
                165                 170                 175     


Asp Val His Asp Ala Ala Asp Asn Pro Leu Pro Tyr Ser Asn Ile Met 
            180                 185                 190         


Tyr Ala Leu His Phe Tyr Ala Gly Thr His Gly Gln Ser Leu Arg Asp 
        195                 200                 205             


Lys Ile Asp Tyr Ala Leu Ser Lys Gly Val Ala Ile Phe Val Thr Glu 
    210                 215                 220                 


Trp Gly Thr Ser Asp Ala Ser Gly Asn Gly Gly Pro Phe Leu Asn Glu 
225                 230                 235                 240 


Ser Gln Lys Trp Ile Asp Phe Met Asn Ser Arg Asn Ile Ser Trp Ala 
                245                 250                 255     


Asn Trp Ser Leu Ser Asp Lys Ser Glu Thr Ser Ala Ala Leu Met Pro 
            260                 265                 270         


Gly Ala Ser Pro Thr Gly Gly Trp Thr Asp Ser Asn Leu Ser Ala Ser 
        275                 280                 285             


Gly Lys Phe Val Arg Glu Gln Ile Arg 
    290                 295         


<210>  12
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ancestral endocelullase

<400>  12

Thr Pro Val Glu Ile Asn Gly Gln Leu Gln Val Cys Gly Val Gln Leu 
1               5                   10                  15      


Cys Asn Gln Tyr Gly Lys Pro Ile Gln Leu Arg Gly Met Ser Thr His 
            20                  25                  30          


Gly Ile Gln Trp Phe Gly Asn Cys Val Asn Asn Ala Ser Leu Asp Ala 
        35                  40                  45              


Leu Ala Asn Asp Trp Arg Ala Asp Ile Phe Arg Ile Ala Met Tyr Ile 
    50                  55                  60                  


Gln Glu Asp Gly Tyr Glu Thr Asn Pro Ala Gly Thr Asn Arg Val Asn 
65                  70                  75                  80  


Asn Leu Val Glu Glu Ala Thr Ala Arg Gly Met Tyr Val Leu Ile Asp 
                85                  90                  95      


Trp His Ile Leu Thr Pro Gly Asp Pro Asn Tyr Asn Leu Asp Arg Ala 
            100                 105                 110         


Lys Thr Phe Phe Ala Glu Ile Ala Ala Arg His Ala Ser Lys Thr Asn 
        115                 120                 125             


Val Ile Tyr Glu Ile Ala Asn Glu Pro Asn Gly Gly Val Ser Trp Ser 
    130                 135                 140                 


Asn Thr Ile Lys Ser Tyr Ala Glu Glu Val Ile Pro Val Ile Arg Ala 
145                 150                 155                 160 


Asn Asp Pro Asp Ser Val Val Ile Val Gly Thr Arg Gly Trp Ser Ser 
                165                 170                 175     


Asp Ser Thr Glu Ile Val Asn Asn Pro Val Asn Ala Ser Asn Ile Met 
            180                 185                 190         


Tyr Ala Phe His Phe Tyr Ala Ala Ser His Arg Asp Asn Tyr Arg Asp 
        195                 200                 205             


Glu Val Glu Arg Ala Ala Ala Arg Gly Leu Pro Val Phe Val Thr Glu 
    210                 215                 220                 


Phe Gly Thr Val Thr Tyr Thr Gly Asp Gly Gly Asn Asp Leu Ala Ser 
225                 230                 235                 240 


Ser Gln Lys Trp Leu Asp Leu Leu Asp Ala Arg Lys Ile Gly Trp Ala 
                245                 250                 255     


Asn Trp Asn Phe Ser Asp Lys Ala Glu Ser Ser Ala Ala Leu Arg Pro 
            260                 265                 270         


Gly Thr Cys Ala Gly Gly Ser Trp Thr Gly Thr Ser Leu Thr Pro Ser 
        275                 280                 285             


Gly Val Phe Val Arg Glu Arg Ile Arg 
    290                 295         


<210>  13
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ancestral endocellulase

<400>  13

Thr Pro Val Glu Thr His Gly Gln Leu Ser Val Lys Gly Gly Gln Leu 
1               5                   10                  15      


Val Asp Glu Asn Gly Lys Pro Val Gln Leu Arg Gly Met Ser Ser His 
            20                  25                  30          


Gly Leu Gln Trp Phe Gly Asp Phe Val Asn Lys Asp Ser Met Lys Trp 
        35                  40                  45              


Leu Arg Asp Asp Trp Gly Ile Asn Val Phe Arg Val Ala Met Tyr Thr 
    50                  55                  60                  


Ala Glu Asp Gly Tyr Ile Thr Asn Pro Ser Val Lys Asn Lys Val Lys 
65                  70                  75                  80  


Glu Ala Val Glu Ala Ala Ile Asp Leu Gly Met Tyr Val Ile Ile Asp 
                85                  90                  95      


Trp His Ile Leu Ser Asp Asn Asp Pro Asn Thr Tyr Lys Ala Gln Ala 
            100                 105                 110         


Lys Ala Phe Phe Gln Glu Met Ala Ala Leu Tyr Gly Asn Tyr Pro Asn 
        115                 120                 125             


Val Ile Tyr Glu Ile Ala Asn Glu Pro Asn Gly Asn Val Thr Trp Asn 
    130                 135                 140                 


Asn Gln Ile Lys Pro Tyr Ala Glu Glu Val Ile Pro Val Ile Arg Ala 
145                 150                 155                 160 


Lys Asp Pro Asp Asn Ile Ile Ile Val Gly Thr Gly Thr Trp Ser Gln 
                165                 170                 175     


Asp Val His Asp Ala Ala Asp Asn Pro Leu Pro Asp Ser Asn Ile Met 
            180                 185                 190         


Tyr Ala Leu His Phe Tyr Ala Gly Thr His Gly Gln Phe Leu Arg Asp 
        195                 200                 205             


Arg Ile Asp Tyr Ala Leu Ser Lys Gly Ala Ala Ile Phe Val Thr Glu 
    210                 215                 220                 


Trp Gly Thr Ser Asp Ala Ser Gly Asn Gly Gly Pro Phe Leu Pro Glu 
225                 230                 235                 240 


Ser Gln Glu Trp Ile Asp Phe Met Asn Ser Arg Lys Ile Ser Trp Ala 
                245                 250                 255     


Asn Trp Ser Leu Ser Asp Lys Ser Glu Thr Ser Ala Ala Leu Met Pro 
            260                 265                 270         


Gly Ala Ser Pro Thr Gly Gly Trp Thr Glu Ser Gln Leu Ser Ala Ser 
        275                 280                 285             


Gly Lys Phe Val Arg Glu Gln Ile Arg 
    290                 295         


<210>  14
<211>  163
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  14

Met Thr Pro Gly Glu Glu Phe Tyr Val Glu Ala Ala Val Asn Ala Ala 
1               5                   10                  15      


Gly Pro Gly Phe Val Asn Ile Lys Ala Ser Ile Ile Asn Lys Ser Gly 
            20                  25                  30          


Trp Pro Ala Arg Gly Ser Asp Lys Leu Ser Ala Lys Tyr Phe Val Asp 
        35                  40                  45              


Ile Ser Glu Ala Val Ala Lys Gly Ile Thr Leu Asp Gln Ile Thr Val 
    50                  55                  60                  


Gln Ser Thr Thr Asn Gly Gly Ala Lys Val Ser Gln Leu Leu Pro Trp 
65                  70                  75                  80  


Asp Pro Asp Asn His Ile Tyr Tyr Val Asn Ile Asp Phe Thr Gly Ile 
                85                  90                  95      


Asn Ile Phe Pro Gly Gly Ile Asn Glu Tyr Lys Arg Asp Val Tyr Phe 
            100                 105                 110         


Thr Ile Thr Ala Pro Tyr Gly Glu Gly Asn Trp Asp Asn Thr Asn Asp 
        115                 120                 125             


Phe Ser Phe Gln Gly Leu Glu Gln Gly Phe Thr Ser Lys Lys Thr Glu 
    130                 135                 140                 


Tyr Ile Pro Leu Tyr Asp Gly Asn Val Arg Val Trp Gly Lys Val Pro 
145                 150                 155                 160 


Asp Arg Ser 
            


<210>  15
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  15

Phe Thr Val Gln Trp Lys Lys Ser Ser Ser Trp Glu Glu Gly Gly Lys 
1               5                   10                  15      


Lys Cys Gly Gly Tyr Glu Ile Val Ile Thr Asn Asn Gly Asp Thr Val 
            20                  25                  30          


Asn Ser Trp Thr Ala Lys Val Thr Val Pro Gly Asn Thr Lys Leu Met 
        35                  40                  45              


Ser Gln Trp Asn Gly Ile Phe Ser Ile Ser Gly Asn Thr Met Thr Val 
    50                  55                  60                  


Lys Asn Glu Ser Tyr Asn Gly Thr Ile Glu Lys Gly Lys Ser Ile Ser 
65                  70                  75                  80  


Phe Gly Phe Asn Tyr Ser Ala 
                85          


<210>  16
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  16

Tyr Gln Leu Lys Val Thr Val Ser Ser Ser Trp Glu Ser Gly Asp Gly 
1               5                   10                  15      


Tyr Gly Gly Thr Tyr Ser Leu Ser Phe Thr Asn Arg Ser Ala Ala Val 
            20                  25                  30          


Lys Ala Trp Asp Ala Gln Ile Glu Val Pro Glu Gly Ser Lys Val Thr 
        35                  40                  45              


Glu Ala Trp Gly Cys Glu Thr Gly Ile Asp Gly Thr Ile Leu Thr Val 
    50                  55                  60                  


Thr Ala Lys Asp Trp Gly Ala Ala Val Ala Lys Gly Ser Thr Val Glu 
65                  70                  75                  80  


Ile Gly Phe Asn Met Asp Thr 
                85          


<210>  17
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  17

Tyr Lys Ala Asp Phe Lys Val Val Asn Ser Trp Glu Glu Gly Gly Lys 
1               5                   10                  15      


Lys Cys Tyr Gln Leu Ser Gly Thr Leu Thr Asn Leu Ser Ser Ser Ile 
            20                  25                  30          


Ser Ser Trp Thr Val Val Phe Asp Ala Gly Asn Gly Ala Glu Ile Lys 
        35                  40                  45              


Gln Phe Trp Asn Ser Lys Cys Thr Ile Ser Gly Asn Lys Ile Thr Val 
    50                  55                  60                  


Gly Pro Ala Asp Tyr Asn Ser Arg Ile Gly Thr Gly Ala Ser Val Ser 
65                  70                  75                  80  


Asp Val Gly Met 
                


<210>  18
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  18

Phe Tyr Ala Glu Ile Gly His Asp Ser Thr Trp Glu Ala Ser Gly Lys 
1               5                   10                  15      


Thr Cys Ala Thr Glu Asn Ile Asn Ile Tyr Asn Lys Thr Ser Ser Val 
            20                  25                  30          


Ser Gly Trp Lys Leu Asp Val Ile Tyr Lys Gly Lys Pro Ala Ile Glu 
        35                  40                  45              


Asp Ile Trp Asn Gly Glu Lys Lys Ile Asn Glu Tyr Thr Val Ser Ile 
    50                  55                  60                  


Thr Pro Ala Asp Tyr Asn Gln Asp Ile Pro Ala Gly Gly Ser Val Asn 
65                  70                  75                  80  


Val Gly Tyr Asn Ile Ala Ser 
                85          


<210>  19
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  19

Tyr Tyr Ala Ser Ile Ser Asp Asn Ser Ser Trp Gln Glu Asn Gly Lys 
1               5                   10                  15      


Asn Ala Ala Thr Lys Asn Val Ile Ile Tyr Asn Lys Asp Lys Lys Val 
            20                  25                  30          


Thr Gly Trp Lys Ile Glu Leu Val Phe Ala Ser Glu Pro Glu Leu Ala 
        35                  40                  45              


Asp Ile Trp Gly Gly Lys Ala Glu Val Asn Gly Asp Thr Ile Thr Val 
    50                  55                  60                  


Val Gly Tyr Asp Tyr Thr Ala Glu Leu Lys Ala Gly Gly Asn Val Asn 
65                  70                  75                  80  


Phe Gly Phe Asn Val Lys Ala 
                85          


<210>  20
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  20

Trp Ala Glu Gln Asn Gln Thr Ala Phe Gln Tyr Glu Leu Leu Phe Ser 
1               5                   10                  15      


Asn Gln Ser Glu Ala Phe Gly Thr Trp Lys Val Ile Leu Asp Thr Gly 
            20                  25                  30          


Lys Glu Val Lys Val Gln Asn Ser Trp Asn Cys Ser Leu Glu Ala Asp 
        35                  40                  45              


Gly Asn Leu Leu Thr Phe Thr Pro Ala Asp Tyr Asn Ala Lys Leu Ala 
    50                  55                  60                  


Lys Gly Ala Glu Met Ala Asp Val Gly Met Ile Leu Val 
65                  70                  75          


<210>  21
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  21

Met Gln Phe Lys Gln Ser Asn Ser Trp Glu Gly Asn Gly Arg Phe Tyr 
1               5                   10                  15      


Ala Gln Tyr Asp Leu Ile Ile Asp Asn Lys Glu Asp Val Ile Ser Asp 
            20                  25                  30          


Trp Thr Phe Lys Ile Asn Thr Thr Asn Gly Thr Thr Leu Glu Gln Ser 
        35                  40                  45              


Trp Asn Cys Thr Val Asp Thr Ser Asp Leu Gln Trp Ser Val Val Pro 
    50                  55                  60                  


Val Asp Tyr Asn Lys Ile Ile Glu Ser Gln Ala Gln Met Asn Asn Val 
65                  70                  75                  80  


Gly Phe Ile Ile Ser 
                85  


<210>  22
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  22

Asn Gly Ile Ser Val Gln Tyr Arg Ala Gly Asp Gly Ser Met Asn Ser 
1               5                   10                  15      


Asn Gln Ile Arg Pro Gln Leu Gln Ile Lys Asn Asn Gly Asn Thr Thr 
            20                  25                  30          


Val Asp Leu Lys Asp Val Thr Ala Arg Tyr Trp Tyr Asn Ala Lys Asn 
        35                  40                  45              


Lys Gly Gln Asn Val Asp Cys Asp Tyr Ala Gln Leu Gly Cys Gly Asn 
    50                  55                  60                  


Val Thr Tyr Lys Phe Val Thr Leu His Lys Pro Lys Gln Gly Ala Asp 
65                  70                  75                  80  


Thr Tyr Leu Glu Leu Gly Phe Lys Asn Gly Thr Leu Ala Pro Gly Ala 
                85                  90                  95      


Ser Thr Gly Asn Ile Gln Leu Arg Leu His Asn Asp Asp Trp Ser Asn 
            100                 105                 110         


Tyr Ala Gln Ser Gly Asp Tyr Ser Phe Phe Lys Ser Asn Thr Phe Lys 
        115                 120                 125             


Thr Thr Lys Lys Ile Thr Leu Tyr Asp Gln Gly Lys Leu Ile Trp Gly 
    130                 135                 140                 


Thr Glu Pro 
145         


<210>  23
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  23

Asn Gly Ile Ser Val Gln Tyr Arg Ala Gly Asp Gly Ser Met Asn Ser 
1               5                   10                  15      


Asn Gln Ile Arg Pro Gln Leu Gln Ile Lys Asn Asn Gly Asn Thr Thr 
            20                  25                  30          


Val Asp Leu Lys Asp Val Thr Ala Arg Tyr Trp Tyr Lys Ala Lys Asn 
        35                  40                  45              


Lys Gly Gln Asn Val Asp Cys Asp Tyr Ala Gln Ile Gly Cys Gly Asn 
    50                  55                  60                  


Val Thr Tyr Lys Phe Val Thr Leu His Lys Pro Lys Gln Gly Ala Asp 
65                  70                  75                  80  


Thr Tyr Leu Glu Leu Gly Phe Lys Asn Gly Thr Leu Ala Pro Gly Ala 
                85                  90                  95      


Ser Thr Gly Asn Ile Gln Leu Arg Leu His Asn Asp Asp Trp Ser Asn 
            100                 105                 110         


Tyr Ala Gln Ser Gly Asp Tyr Ser Phe Phe Lys Ser Asn Thr Phe Lys 
        115                 120                 125             


Thr Thr Lys Lys Ile Thr Leu Tyr Asp 
    130                 135         


<210>  24
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  24

Asn Gly Ile Ser Val Gln Tyr Lys Ala Gly Asp Gly Gly Val Asn Ser 
1               5                   10                  15      


Asn Gln Ile Arg Pro Gln Leu His Ile Lys Asn Asn Gly Asn Ala Thr 
            20                  25                  30          


Val Asp Leu Lys Asp Val Thr Ala Arg Tyr Trp Tyr Asn Ala Lys Asn 
        35                  40                  45              


Lys Gly Gln Asn Phe Asp Cys Asp Tyr Ala Gln Ile Gly Cys Gly Asn 
    50                  55                  60                  


Leu Thr His Lys Phe Val Thr Leu His Lys Pro Lys Gln Gly Ala Asp 
65                  70                  75                  80  


Thr Tyr Leu Glu Leu Gly Phe Lys Thr Gly Thr Leu Ser Pro Gly Ala 
                85                  90                  95      


Ser Thr Gly Asn Ile Gln Leu Arg Leu His Asn Asp Asp Trp Ser Asn 
            100                 105                 110         


Tyr Ala Gln Ser Asp Asp Tyr Ser Phe Phe Gln Ser Asn Thr Phe Lys 
        115                 120                 125             


Thr Thr Lys Lys Ile Thr Leu Tyr His Gln Gly Lys Leu Ile Trp Gly 
    130                 135                 140                 


Thr Glu Pro 
145         


<210>  25
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  25

Pro Gly Glu Pro Glu Pro Asp Pro Gly Glu Pro Asp Pro Thr Pro Pro 
1               5                   10                  15      


Ser Asp Gly Asp Tyr Pro Ala Trp Asp Pro Asn Thr Ile Tyr Thr Asp 
            20                  25                  30          


Glu Ile Val Tyr His Asn Gly Gln Leu Trp Gln Ala Lys Trp Trp Thr 
        35                  40                  45              


Gln Asn Gln Glu Pro Gly Asp Tyr Gly Pro Trp Glu Pro Leu Asn 
    50                  55                  60              


<210>  26
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  26

Gly Asn Leu Val Val Gln Tyr Lys Val Gly Asp Thr Ser Ala Thr Asp 
1               5                   10                  15      


Asn Gln Met Lys Pro Ser Phe Asn Ile Lys Asn Asn Gly Thr Thr Pro 
            20                  25                  30          


Val Asn Leu Ser Gly Leu Lys Leu Arg Tyr Tyr Phe Thr Lys Asp Gly 
        35                  40                  45              


Thr Asp Met Ser Ala Ser Ile Asp Trp Ala Gln Ile Gly Ala Ser Asn 
    50                  55                  60                  


Ile Ser Ala Ala Phe Ala Asp Phe Thr Gly Ser Asn Thr Asp Thr Tyr 
65                  70                  75                  80  


Val Glu Leu Ser Phe Ser Ala Gly Ser Ile Pro Ala Gly Gly Gln Thr 
                85                  90                  95      


Gly Asp Ile Gln Leu Arg Met Tyr Lys Thr Asp Trp Ser Asn Phe Asn 
            100                 105                 110         


Glu Ala Asn Asp Tyr Ser Tyr Asp Gly Ala Lys Thr Tyr Ala Asp Trp 
        115                 120                 125             


Asn Arg Val Thr Leu His Gln Asn Gly Thr Leu Val Trp Gly Thr Thr 
    130                 135                 140                 


Pro 
145 


<210>  27
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  27

Asp Pro Gly Glu Pro Asp Pro Thr Pro Pro Ser Asp Gly Glu Tyr Pro 
1               5                   10                  15      


Ala Trp Asp Pro Asn Gln Ile Tyr Thr Asn Glu Ile Val Tyr His Asn 
            20                  25                  30          


Gly Gln Leu Trp Gln Ala Lys Trp Trp Thr Gln Asn Gln Glu Pro Gly 
        35                  40                  45              


Asp Tyr Gly Pro Trp Glu Pro Leu Asn 
    50                  55          


<210>  28
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  28

Gly Ser Leu Val Leu Gln Tyr Arg Ala Ala Asp Thr Asn Ala Gly Asp 
1               5                   10                  15      


Asn Ala Ile Lys Pro His Phe Asn Ile Arg Asn Thr Gly Ala Ser Pro 
            20                  25                  30          


Val Asp Leu Ser Gly Val Lys Leu Arg Tyr Tyr Phe Thr Lys Asp Gly 
        35                  40                  45              


Ile Pro Leu Ser Phe Ala Val Asp Trp Ala Gln Val Gly Ser Pro Asn 
    50                  55                  60                  


Val Lys Gly Thr Phe Gly Ser Ala Ser Gly Ala Gly Ala Asp Thr Tyr 
65                  70                  75                  80  


Leu Glu Val Ser Phe Thr Gly Ser Ile Pro Ala Gly Gly Gln Thr Gly 
                85                  90                  95      


Glu Ile Gln Thr Arg Ile His Lys Ser Asp Trp Ser Ser Phe Gln Glu 
            100                 105                 110         


Ser Gly Asp Tyr Ser Tyr Asp Pro Gly Lys Thr Tyr Ala Asp Trp Ser 
        115                 120                 125             


Lys Val Thr Leu Tyr Arg Asp Gly Thr Arg Val Trp Gly Val Glu Pro 
    130                 135                 140                 


<210>  29
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  29

Asn Ile Thr Ser Ala Val Tyr Thr Ile Ser Asn Thr Asp Pro Val Lys 
1               5                   10                  15      


Gln Val Ser Ala Pro Thr Phe Ser Leu Gln Ser Ala Gln Thr Val Thr 
            20                  25                  30          


Leu Thr Ser Ser Asp Asn Asp Ser Val Ile His Tyr Thr Thr Asp Gly 
        35                  40                  45              


Thr Pro Thr Ser Ser Ser Pro Val Tyr Thr Asn Met Thr Asp Ser Ser 
    50                  55                  60                  


Val Val Thr Asn Thr Tyr Thr Ile Thr Asn Glu Thr Ser Asn Ser Pro 
65                  70                  75                  80  


Val Glu Val Glu Val Glu Tyr Lys Thr Thr Val Lys Val Thr Leu Thr 
                85                  90                  95      


Asn Asn Ser Ser Thr Pro Ile Asn Gly Trp Lys Leu Ser Trp Ile Asn 
            100                 105                 110         


Asn Met Trp Thr Ala Asn Tyr Ser Ile Lys Asp Ser Ala Ile Val Lys 
        115                 120                 125             


Asp Tyr Asn Asn Ile Ile Pro Ala Asn Gly Gly Thr Gln Ile Phe Gly 
    130                 135                 140                 


Phe Ser Ile 
145         


<210>  30
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  30

Gln Gly Ile Val Leu Gln Tyr Arg Thr Gly Asp Thr Asn Thr Lys Asp 
1               5                   10                  15      


Asn Ala Ile Arg Pro Glu Phe Asn Ile Lys Asn Thr Gly Asn Thr Ala 
            20                  25                  30          


Val Lys Leu Ser Asp Leu Lys Ile Arg Tyr Tyr Tyr Thr Asp Glu Ser 
        35                  40                  45              


Lys Gly Gln Gln Leu Phe Val Asp Trp Ala Lys Val Gly Asn Glu Lys 
    50                  55                  60                  


Val Lys Ala Thr Phe Val Ala Leu Pro Glu Pro Lys Ala Lys Ala Asp 
65                  70                  75                  80  


Lys Tyr Val Glu Ile Ser Phe Thr Asp Gly Thr Ile Gln Pro Gly Gly 
                85                  90                  95      


Glu Ser Gly Glu Ile Gln Pro Arg Ile His Ala Ala Asn Trp Ser Asn 
            100                 105                 110         


Phe Asp Glu Thr Asn Asp Tyr Ser Tyr Gly Ala Ser Gln Thr Phe Ala 
        115                 120                 125             


Asn Trp Asp His Ala Thr Val Tyr Gln Gln Gly Lys Leu Val Trp Gly 
    130                 135                 140                 


Ile Glu Pro 
145         


<210>  31
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  31

Glu Gly Ile Val Leu Gln Tyr Arg Thr Asp Asp Thr Asn Ala Lys Asp 
1               5                   10                  15      


Asn Ala Ile Arg Pro Gln Phe Asn Ile Lys Asn Thr Gly Lys Thr Ala 
            20                  25                  30          


Val Lys Leu Ser Asp Leu Lys Ile Arg Tyr Tyr Tyr Thr Asp Glu Ser 
        35                  40                  45              


Lys Ala Gln Gln Phe Phe Val Asp Trp Ala Lys Ile Gly Asn Glu Lys 
    50                  55                  60                  


Val Lys Ala Thr Phe Val Thr Leu Pro Asn Pro Lys Ser Lys Ala Asp 
65                  70                  75                  80  


Lys Tyr Val Glu Ile Ser Phe Thr Asp Gly Thr Ile Gln Pro Gly Gly 
                85                  90                  95      


Glu Thr Gly Glu Ile Gln Ser Arg Ile His Ala Ala Asn Trp Ser Asn 
            100                 105                 110         


Phe Asp Glu Thr Asn Asp Tyr Ser Tyr Gly Ala Ala Gln Thr Phe Ala 
        115                 120                 125             


Asp Trp Asp His Gly Thr Val Tyr Gln Gln Gly Lys Leu Val Trp Gly 
    130                 135                 140                 


Ile Glu Pro 
145         


<210>  32
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  32

Gln Ala Ala Gly Leu Thr Ala Thr Val Thr Lys Glu Ser Ser Trp Asp 
1               5                   10                  15      


Asn Gly Tyr Ser Ala Ser Val Thr Val Arg Asn Asp Thr Ser Ser Val 
            20                  25                  30          


Ser Gln Trp Glu Val Val Leu Thr Leu Pro Gly Gly Thr Thr Val Ala 
        35                  40                  45              


Gln Val Trp Asn Ala Gln His Thr Ser Ser Gly Asn Ser His Thr Phe 
    50                  55                  60                  


Thr Gly Val Ser Trp Asn Ser Thr Ile Pro Pro Gly Gly Thr Ala Ser 
65                  70                  75                  80  


Phe Gly Phe Ile Ala Ser Gly Ser Gly Glu Pro Thr His Cys Thr Ile 
                85                  90                  95      


Asn Gly Ala Pro Cys Asp Glu Gly Ser Glu Pro 
            100                 105         


<210>  33
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  33

Ala Ala Thr Gly Cys Ser Val Thr Tyr Thr Thr Asn Ser Trp Ser Asn 
1               5                   10                  15      


Gly Phe Thr Ala Asn Val Thr Val Thr Asn Leu Gly Asp Ala Ile Gly 
            20                  25                  30          


Asn Trp Thr Leu Gly Phe Ser Phe Pro Ser Gly Gln Arg Val Thr Gln 
        35                  40                  45              


Gly Trp Ser Ala Ile Trp Ser Gln Ser Gly Asn Ala Val Thr Ala Arg 
    50                  55                  60                  


Ser Glu Ser Trp Asn Gly Asn Leu Ala Thr Gly Ala Ser Thr Ser Ile 
65                  70                  75                  80  


Gly Phe Asn Gly Ser Phe Thr Gly Ser Pro Thr Ser Phe Thr Leu Asn 
                85                  90                  95      


Gly Val Pro Cys Thr Gly Ser Thr Thr Thr 
            100                 105     


<210>  34
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  34

Glu Ala Ala Ser Phe Thr Val Thr Asn Ser Trp Ser Thr Gly Tyr Gln 
1               5                   10                  15      


Gly Glu Val Thr Val Ser Asn Pro Ala Ser Ser Ile Asn Thr Trp Lys 
            20                  25                  30          


Val Gln Leu Thr Leu Pro Ala Gly Ser Thr Ile Gly Gln Ala Trp Asn 
        35                  40                  45              


Ala Thr Leu Ala Thr Gly Gly Gln Thr Phe Thr Phe Thr Pro Ala Gly 
    50                  55                  60                  


Trp Asn Gly Thr Ile Ala Gly Gly Ser Ala Thr Ser Phe Gly Phe Val 
65                  70                  75                  80  


Val Thr Gly Thr Gly Arg Pro Thr Ser Cys Thr Val Asn Gly Gln Ala 
                85                  90                  95      


Cys Thr Gly Leu Thr Gly Ala 
            100             


<210>  35
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  35

Ala Ala Thr Gly Cys His Val Asp Tyr Thr Val Thr Asn Gln Trp Gln 
1               5                   10                  15      


Gly Gly Phe Gln Ala Ala Val Lys Val Thr Asn Leu Gly Asp Ala Ile 
            20                  25                  30          


Thr Gly Trp Leu Leu Arg Phe Thr Phe Pro Ala Gly Gln Lys Val Ala 
        35                  40                  45              


Gln Gly Trp Asn Ala Thr Trp Ala Gln Ser Gly Ala Thr Ala Thr Ala 
    50                  55                  60                  


Ala Asn Ala Asp Trp Asn Arg Thr Leu Thr Thr Gly Ala Thr Thr Glu 
65                  70                  75                  80  


Leu Gly Phe Thr Gly Thr Thr Thr Gly Val Pro Ala Ser Phe Thr Leu 
                85                  90                  95      


Asn Gly Val Thr Cys Thr Gly Ser Thr Thr Thr 
            100                 105         


<210>  36
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  36

Ala Ala Thr Gly Cys Ala Val Thr Tyr Thr Thr Asn Ser Trp Gln Gly 
1               5                   10                  15      


Gly Phe Thr Ala Thr Val Ala Val Arg Asn Leu Gly Asp Pro Val Ser 
            20                  25                  30          


Asn Trp Thr Leu Gly Phe Thr Phe Pro Gly Gly Gln Arg Val Val Gln 
        35                  40                  45              


Gly Trp Ser Ala Thr Trp Gln Gln Ser Gly Ser Ala Val Thr Ala Arg 
    50                  55                  60                  


Ser Leu Asp Tyr Asn Gly Ala Leu Gly Thr Gly Ala Ser Thr Thr Ile 
65                  70                  75                  80  


Gly Phe Asn Gly Ser Trp Thr Gly Ser Pro Thr Ser Phe Thr Leu Asn 
                85                  90                  95      


Gly Thr Val Cys Thr Gly Gly Thr Ser Thr 
            100                 105     


<210>  37
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  37

Ala Ala Thr Gly Cys Ala Val Thr Tyr Thr Thr Asn Ser Trp Gln Gly 
1               5                   10                  15      


Gly Phe Thr Ala Thr Val Ala Val Arg Asn Leu Gly Asp Pro Val Ser 
            20                  25                  30          


Asn Trp Thr Leu Gly Phe Thr Phe Pro Gly Gly Gln Arg Val Val Gln 
        35                  40                  45              


Gly Trp Ser Ala Thr Trp Gln Gln Ser Gly Ser Ala Val Thr Ala Arg 
    50                  55                  60                  


Ser Leu Asp Tyr Asn Gly Ala Leu Gly Thr Gly Ala Ser Thr Thr Ile 
65                  70                  75                  80  


Gly Phe Asn Gly Ser Trp Thr Gly Ser Pro Thr Ser Phe Thr Leu Asn 
                85                  90                  95      


Gly Thr Val Cys Thr Gly Gly Thr Ser Thr 
            100                 105     


<210>  38
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  38

Glu Ser Glu Asn Ala Thr Ile Ser Arg Gly Val Val Glu Ala Asn His 
1               5                   10                  15      


Thr Gly Phe Thr Gly Ser Gly Phe Val Asn Tyr Asp Asn Val Thr Gly 
            20                  25                  30          


Ser Tyr Val Glu Tyr Thr Val Asn Ala Ala Gln Ala Gly Pro His Thr 
        35                  40                  45              


Leu Thr Phe Arg Tyr Ala Asn Gly Thr Thr Ala Asn Arg Pro Leu Asp 
    50                  55                  60                  


Ile Thr Val Asn Gly Ser Ile Ala Val Asp Asp Leu Gly Phe Ala Gly 
65                  70                  75                  80  


Thr Gly Ala Trp Ser Thr Val Thr Thr Thr Val Asn Leu Ala Ala Gly 
                85                  90                  95      


Ser Asn Lys Ile 
            100 


<210>  39
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  39

Asn Ala Ala Gly Cys Arg Val Asp Tyr Thr Val Thr Asn Gln Trp Gln 
1               5                   10                  15      


Gly Gly Phe Gln Ala Gly Val Lys Ile Thr Asn Leu Gly Asp Thr Val 
            20                  25                  30          


Arg Gly Trp Thr Leu Lys Phe Thr Leu Pro Thr Gly Gln Lys Val Val 
        35                  40                  45              


Gln Gly Trp Ser Ala Ala Trp Ser Gln Ser Gly Ser Thr Val Thr Val 
    50                  55                  60                  


Ala Gly Ala Asp Trp Asn Gly Thr Leu Ala Thr Gly Ala Ser Ala Asp 
65                  70                  75                  80  


Thr Gly Phe Val Gly Ser Phe Thr Gly Lys Pro Thr Ala Phe Thr Leu 
                85                  90                  95      


Asn Gly Val Ala Cys Thr Gly Ser Val Asp Asp 
            100                 105         


<210>  40
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  40

Ala Ala Thr Gly Cys Lys Ala Glu Tyr Thr Ile Thr Ser Gln Trp Glu 
1               5                   10                  15      


Gly Gly Phe Gln Ala Gly Val Lys Ile Thr Asn Leu Gly Asp Pro Val 
            20                  25                  30          


Ser Gly Trp Thr Leu Gly Phe Thr Met Pro Ala Gly Gln Arg Leu Val 
        35                  40                  45              


Gln Gly Trp Asn Ala Thr Trp Ser Gln Ser Gly Ser Ala Val Thr Ala 
    50                  55                  60                  


Gly Gly Val Asp Trp Asn Arg Thr Leu Ala Thr Gly Ala Ser Ala Asp 
65                  70                  75                  80  


Leu Gly Phe Val Gly Ser Phe Thr Gly Ala Pro Thr Ser Phe Thr Leu 
                85                  90                  95      


Asn Gly Ala Thr Cys Ser Gly Ser Val 
            100                 105 


<210>  41
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  41

Asp Gly Ile Gln Thr Glu Ser Thr Thr Asp Thr Gly Gly Gly Leu Asn 
1               5                   10                  15      


Ile Gly Trp Thr Asp Ala Gly Asp Trp Thr Ser Pro Ala Ala Gly Arg 
            20                  25                  30          


Tyr Lys Val Ser Tyr Arg Asn Ser Gly Met Leu Gln Leu Glu Ala Ala 
        35                  40                  45              


Gly Gly Phe Pro Thr Tyr Gly Ser Ile Thr Gly Gly Trp Gln Ser Trp 
    50                  55                  60                  


Gln Thr Ile Ser His Glu Val Asn Leu Asn Trp Ile Lys Val Glu Pro 
65                  70                  75                  80  


Ala 
    


<210>  42
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  42

Pro Thr Glu Pro Thr Asn Pro Gly Asn Gly Thr Thr Gly Asp Val Val 
1               5                   10                  15      


Leu Gln Tyr Arg Asn Val Asp Asn Asn Pro Ser Asp Asp Ala Ile Arg 
            20                  25                  30          


Met Ala Val Asn Ile Lys Asn Thr Gly Ser Thr Pro Ile Lys Leu Ser 
        35                  40                  45              


Asp Leu Gln Val Arg Tyr Tyr Phe His Asp Asp Gly Lys Pro Gly Ala 
    50                  55                  60                  


Asn Leu Phe Val Asp Trp Ala Asn Val Gly Pro Asn Asn Ile Val Thr 
65                  70                  75                  80  


Ser 
    


<210>  43
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  43

Pro Thr Glu Pro Thr Asn Pro Gly Asn Gly Thr Thr Gly Asp Ile Val 
1               5                   10                  15      


Leu Gln Tyr Arg Asn Val Asp Asn Asn Pro Ser Asp Asp Ala Ile Arg 
            20                  25                  30          


Met Ala Phe Asn Ile Lys Asn Thr Gly Ser Thr Pro Ile Lys Leu Ser 
        35                  40                  45              


Asp Leu Gln Val Arg Tyr Tyr Phe His Asp Asp Gly Lys Pro Gly Ala 
    50                  55                  60                  


Asn Leu Phe Val Asp Trp Ala Asn Val Gly Pro Asn Asn Ile Val Thr 
65                  70                  75                  80  


Ser 
    


<210>  44
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Carbohydrate binding domain

<400>  44

Ser Ser Ser Ser Ala Val Ser Ser Gln Thr Gln Val Ser Ser Ser Ser 
1               5                   10                  15      


Gln Ala Pro Val Val Ser Ser Ser Ser Ser Thr Ala Ser Ser Val Val 
            20                  25                  30          


Ser Ser Ala Val Ser Gly Tyr Gly Thr Leu Tyr Pro Leu Cys Ser Thr 
        35                  40                  45              


Thr Thr Asn Gly Trp Gly Trp Glu Asn Asn Ala Ser Cys Ile Ala Arg 
    50                  55                  60                  


Ala Thr Cys Ser Gly Gln Pro Ser Ser Ser Val Arg Ser Ser 
65                  70                  75              


