                         SEQUENCE LISTING

<110>  Institute of Genetics and Developmental Biology, Chinese 
       Academy of Sciences
 
<120>  Base editing system and method based on CPF1 protein

<130>  P20182839

<150>  201711403490.X
<151>  2017-12-22

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  227
<212>  PRT
<213>  Rattus norvegicus

<400>  1

Ser Ser Glu Thr Gly Pro Val Ala Val Asp Pro Thr Leu Arg Arg Arg 
1               5                   10                  15      


Ile Glu Pro His Glu Phe Glu Val Phe Phe Asp Pro Arg Glu Leu Arg 
            20                  25                  30          


Lys Glu Thr Cys Leu Leu Tyr Glu Ile Asn Trp Gly Gly Arg His Ser 
        35                  40                  45              


Ile Trp Arg His Thr Ser Gln Asn Thr Asn Lys His Val Glu Val Asn 
    50                  55                  60                  


Phe Ile Glu Lys Phe Thr Thr Glu Arg Tyr Phe Cys Pro Asn Thr Arg 
65                  70                  75                  80  


Cys Ser Ile Thr Trp Phe Leu Ser Trp Ser Pro Cys Gly Glu Cys Ser 
                85                  90                  95      


Arg Ala Ile Thr Glu Phe Leu Ser Arg Tyr Pro His Val Thr Leu Phe 
            100                 105                 110         


Ile Tyr Ile Ala Arg Leu Tyr His His Ala Asp Pro Arg Asn Arg Gln 
        115                 120                 125             


Gly Leu Arg Asp Leu Ile Ser Ser Gly Val Thr Ile Gln Ile Met Thr 
    130                 135                 140                 


Glu Gln Glu Ser Gly Tyr Cys Trp Arg Asn Phe Val Asn Tyr Ser Pro 
145                 150                 155                 160 


Ser Asn Glu Ala His Trp Pro Arg Tyr Pro His Leu Trp Val Arg Leu 
                165                 170                 175     


Tyr Val Leu Glu Leu Tyr Cys Ile Ile Leu Gly Leu Pro Pro Cys Leu 
            180                 185                 190         


Asn Ile Leu Arg Arg Lys Gln Pro Gln Leu Thr Phe Phe Thr Ile Ala 
        195                 200                 205             


Leu Gln Ser Cys His Tyr Gln Arg Leu Pro Pro His Ile Leu Trp Ala 
    210                 215                 220                 


Thr Gly Leu 
225         


<210>  2
<211>  87
<212>  PRT
<213>  Bacillus phage

<400>  2

Thr Asn Leu Ser Asp Ile Ile Glu Lys Glu Thr Gly Lys Gln Leu Val 
1               5                   10                  15      


Ile Gln Glu Ser Ile Leu Met Leu Pro Glu Glu Val Glu Glu Val Ile 
            20                  25                  30          


Gly Asn Lys Pro Glu Ser Asp Ile Leu Val His Thr Ala Tyr Asp Glu 
        35                  40                  45              


Ser Thr Asp Glu Asn Val Met Leu Leu Thr Ser Asp Ala Pro Glu Tyr 
    50                  55                  60                  


Lys Pro Trp Ala Leu Val Ile Gln Asp Ser Asn Gly Glu Asn Lys Ile 
65                  70                  75                  80  


Lys Met Leu Ser Gly Gly Ser 
                85          


<210>  3
<211>  167
<212>  PRT
<213>  Escherichia coli

<400>  3

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp 
                165         


<210>  4
<211>  167
<212>  PRT
<213>  Escherichia coli

<400>  4

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala 
        35                  40                  45              


Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp 
                165         


<210>  5
<211>  3990
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ASCPF1-2NLS

<400>  5
atgacgcagt tcgaggggtt caccaacctc taccaggtca gcaagacgct gcggttcgag       60

ctgattccgc agggcaagac cctcaagcac atccaggagc agggctttat cgaggaggac      120

aaagcgcgga acgaccacta caaggagctc aagccgatca tcgaccggat ctacaagacc      180

tacgcggacc agtgcctgca gctcgtgcag ctcgactggg agaacctctc ggccgccatc      240

gactcctacc gcaaggagaa gacggaggag acacgcaacg cgctcatcga agaacaggct      300

acgtatcgca acgctatcca cgactacttc atcgggcgca cagataatct caccgacgcc      360

atcaacaagc gccacgccga aatctataag gggctgttta aggccgagct gttcaatggc      420

aaagtgctga agcaactggg caccgtcacg accacagagc atgagaacgc cctcctccgg      480

tcgttcgaca agtttacgac atactttagc ggcttttacg agaaccgcaa aaacgtgttc      540

agcgccgagg acattagcac cgccatcccg cataggatcg tgcaagacaa cttcccgaag      600

ttcaaggaga actgccacat cttcacccgc ctcatcacgg ccgtgccgtc cctccgcgag      660

cacttcgaga acgtgaagaa ggccatcggg atcttcgtgt ccacctcgat cgaagaggtg      720

ttctccttcc ccttctacaa tcagctgctg acgcagaccc agatcgacct ctacaaccag      780

ctcctcggcg gcatctcccg cgaggccggc accgagaaga tcaagggcct gaacgaggtg      840

ctcaatctcg ccatccagaa gaacgacgaa accgcgcaca tcattgcctc actcccacat      900

aggtttatcc ccctgtttaa gcagatcctc tccgaccgca acacgttgtc cttcatcctc      960

gaggagttca agagcgacga ggaggtcatc cagtccttct gcaagtacaa gaccctcctc     1020

cgcaacgaga atgtgctcga aaccgccgag gcgctgttca atgagctcaa tagcatcgat     1080

ctcacccaca tcttcatctc ccataagaag ctggaaacca tctccagcgc cctgtgcgac     1140

cactgggaca ccctccgcaa cgccctctac gagcggcgca tcagcgagct caccggcaag     1200

atcacgaagt cggcgaaaga gaaagtgcaa aggagcctca agcacgagga cattaacctg     1260

caggagatca tctccgccgc gggcaaggag ctgtccgagg ctttcaagca gaagacctcg     1320

gagatcctct ctcacgccca cgcggccctg gaccagccgc tgccgacgac cctgaaaaag     1380

caagaggaaa aggaaatcct caagtcccag ctggacagcc tcctggggct gtaccacctt     1440

ctcgactggt tcgccgtgga cgagtccaac gaggtcgatc cggagtttag cgcccgcctc     1500

accgggatca agcttgagat ggaacctagc ttgagcttct ataataaggc gcgcaattac     1560

gcgaccaaga agccgtattc cgtggagaag ttcaagctga acttccaaat gcccaccctg     1620

gccagcgggt gggacgttaa caaagagaag aacaacggag ccattctttt cgtgaaaaat     1680

gggttgtatt atttgggaat tatgccgaaa caaaaaggca ggtacaaggc gctcagcttc     1740

gagccaactg agaagacctc cgagggcttc gacaagatgt actacgatta ttttcctgac     1800

gctgcaaaga tgataccgaa gtgcagcact cagcttaagg cggtgacggc gcactttcag     1860

acccatacca cccccatcct cctctccaac aacttcatcg agccgctcga gatcaccaag     1920

gagatatacg atctgaataa tccagaaaag gaacccaaga agttccagac cgcctacgcc     1980

aagaagacgg gcgatcaaaa ggggtataga gaggcgctct gcaagtggat cgacttcacg     2040

cgcgatttcc tcagcaagta caccaagaca acctccatcg atctctcttc cctccgcccc     2100

tcttcccagt acaaggacct cggggagtac tacgccgaac tcaacccact cctgtatcac     2160

atctcgtttc agcgtatcgc ggaaaaggag atcatggacg ccgtcgaaac cggcaagttg     2220

tatcttttcc aaatctataa caaggacttc gcgaagggcc accacgggaa gccaaacctg     2280

cacaccctct actggacagg cctcttcagc ccggaaaatc tcgcgaagac gagcataaag     2340

ctgaacggcc aggcagaact cttctacagg ccgaagtcca ggatgaagcg catggctcat     2400

cgcctcggtg agaagatgct gaacaagaag ctgaaagatc aaaagacgcc aatccctgat     2460

acactgtatc aggagctgta cgattacgtg aaccaccgcc tctcacacga cctcagcgac     2520

gaggcccgcg cgctcctgcc aaacgtcatc acgaaggagg tcagccacga gatcataaag     2580

gatcggcggt ttacctctga caagttcttt ttccatgtcc ccatcacgct gaactaccag     2640

gccgcgaata gcccgtccaa gttcaaccag cgggtcaacg cgtatctcaa ggagcaccca     2700

gagacaccca taatcgggat tgaccggggg gagcggaacc tcatctacat caccgtcatc     2760

gactccaccg gaaagattct cgagcaacgg tcgctcaata ccatccagca gttcgactac     2820

cagaagaagc tcgacaaccg ggagaaggaa cgcgtcgccg cgaggcaggc ctggtccgta     2880

gtgggcacga tcaaagacct gaagcagggc tatctcagcc aggtcatcca tgagatagtg     2940

gatctcatga tccactacca agccgtcgtg gtcctcgaga atctcaattt cggattcaaa     3000

tccaagcgca caggcatcgc cgagaaggcg gtgtaccaac agttcgagaa aatgcttatc     3060

gacaagctca attgcctggt gctcaaggac tatccggcgg agaaggtcgg gggggtcctc     3120

aatccgtatc agctgaccga ccagtttacg tcatttgcga agatgggcac ccagagcggc     3180

ttccttttct atgtcccggc cccatatacc tcaaagattg atcccttgac cggattcgtg     3240

gacccgtttg tctggaagac catcaagaac catgagtcgc gtaagcattt cctggagggt     3300

ttcgacttcc tgcactatga tgtaaaaacc ggagacttca tcctgcattt caagatgaat     3360

cggaacctct ccttccagcg gggactccct ggcttcatgc ccgcttggga tatcgttttt     3420

gagaaaaatg aaacccaatt cgacgccaaa ggcacgcctt tcatcgcggg caagaggatt     3480

gtccctgtaa ttgagaacca tagattcacc gggcgttacc gtgacctgta ccccgcaaac     3540

gaactcatcg ccctcctgga ggagaaaggc atcgttttcc gcgacgggtc aaatatcctc     3600

cccaaactgc tcgagaacga tgatagccac gctattgaca cgatggtagc gctcatcaga     3660

tccgtgctgc aaatgagaaa ttcaaatgct gccactgggg aggattacat caactcccct     3720

gtgcgtgatc tcaatggcgt gtgcttcgat tctagatttc agaatcctga gtggccgatg     3780

gatgccgatg ctaacggcgc ataccacata gcattgaaag gacaactgtt gttgaaccat     3840

ctcaaggaga gcaaggacct taagctgcag aacggcatca gcaaccagga ttggcttgcc     3900

tatatccaag agctccgcaa ttccggcggc agcccaaaga agaagaggaa ggtgagcggc     3960

ggcagcccaa agaagaagcg caaggtctag                                      3990


<210>  6
<211>  3969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>   FNCPF1-2NLS

<400>  6
atgtccatct accaggagtt cgtcaataag tactcactct ctaagaccct gcggttcgag       60

ctgatcccgc agggcaagac actcgagaac atcaaggcgc gcggcctgat tctcgacgat      120

gagaagcggg ccaaggacta caagaaggcg aagcagatca ttgataagta ccaccagttc      180

ttcatcgagg agattctgtc cagcgtgtgc atctctgagg atctcctgca gaattactcc      240

gacgtctact tcaagctcaa gaagtctgac gatgacaacc tgcagaagga tttcaagtcc      300

gccaaggaca ccatcaagaa gcagatttct gagtacatca aggattccga gaagttcaag      360

aatctcttca accagaatct gattgatgcg aagaagggcc aggagtctga cctgatcctc      420

tggctgaagc agtccaagga caatggcatt gagctgttca aggccaacag cgatatcacc      480

gatattgacg aggcgctgga gatcattaag tcattcaagg gctggaccac atacttcaag      540

ggcttccatg agaaccggaa gaatgtgtac tcatctaacg acattccgac ctccatcatc      600

tacaggatcg tcgatgacaa tctgccaaag ttcctcgaga acaaggccaa gtacgagtcc      660

ctcaaggaca aggccccgga ggcgattaat tacgagcaga tcaagaagga tctggcggag      720

gagctgacct tcgatatcga ctacaagaca agcgaggtga accagagggt gttctccctc      780

gatgaggtgt tcgagatcgc caatttcaac aattacctga accagtccgg cattaccaag      840

ttcaatacaa tcattggcgg caagttcgtc aacggcgaga ataccaagcg caagggcatt      900

aacgagtaca tcaatctcta ctcccagcag atcaacgaca agaccctgaa gaagtacaag      960

atgtctgtgc tcttcaagca gatcctgtcc gatacagagt ccaagagctt cgtcattgat     1020

aagctcgagg acgacagcga cgtggtcacc acaatgcagt cattctacga gcagatcgcc     1080

gcgttcaaga ccgtggagga gaagagcatt aaggagacac tctcactcct gttcgatgac     1140

ctgaaggccc agaagctcga cctgagcaag atctacttca agaacgataa gagcctcaca     1200

gacctgtcac agcaggtgtt cgatgactac tcagtgattg gcaccgccgt cctcgagtac     1260

attacacagc agatcgcgcc aaagaacctc gataatcctt ctaagaagga gcaggagctg     1320

atcgccaaga aaaccgagaa ggcgaagtac ctctccctgg agacaattaa gctcgccctg     1380

gaggagttca ataagcacag ggatattgac aagcagtgcc gcttcgagga gatcctcgcg     1440

aacttcgccg cgatcccaat gattttcgat gagatcgccc agaacaagga caatctggcg     1500

cagatctcta ttaagtacca gaaccagggc aagaaggacc tcctgcaggc ctccgcagag     1560

gacgacgtga aggccatcaa ggatctcctg gaccagacca acaatctcct gcacaagctc     1620

aagatcttcc atatttcaca gtctgaggat aaggccaata tcctcgataa ggacgagcat     1680

ttctacctgg tgttcgagga gtgctacttc gagctggcga acattgtccc tctgtacaac     1740

aagattagga attacatcac acagaagccg tacagcgacg agaagttcaa gctcaacttc     1800

gagaattcaa ccctggccaa cggctgggat aagaataagg agcctgacaa cacagcgatc     1860

ctcttcatca aggacgacaa gtactacctg ggcgtgatga ataagaagaa caataagatc     1920

ttcgatgaca aggccattaa ggagaacaag ggcgagggct acaagaagat cgtgtacaag     1980

ctcctgcctg gcgccaataa gatgctcccg aaggtgttct tctccgcgaa gtccattaag     2040

ttctacaacc caagcgagga tatcctcagg atcaggaacc actctaccca tacaaagaac     2100

ggctcccctc agaagggcta cgagaagttc gagttcaata tcgaggattg ccggaagttc     2160

attgacttct acaagcagtc catcagcaag caccctgagt ggaaggattt cggcttccgc     2220

ttcagcgaca cccagcggta caactcaatc gatgagttct acagggaggt ggagaatcag     2280

ggctacaagc tcacattcga gaacatttca gagtcttaca tcgactccgt ggtcaatcag     2340

ggcaagctct acctgttcca gatctacaac aaggatttca gcgcctactc aaagggcagg     2400

ccgaacctcc ataccctgta ctggaaggcg ctcttcgatg agcgcaatct gcaggacgtg     2460

gtctacaagc tcaacggcga ggccgagctg ttctaccgca agcagtctat tccgaagaag     2520

atcacacacc cagcgaagga ggccatcgcg aacaagaata aggacaatcc gaagaaggag     2580

tccgtgttcg agtacgatct cattaaggac aagcggttca ccgaggataa gttcttcttc     2640

cattgcccaa tcacaattaa cttcaagtcc agcggcgcca acaagttcaa tgacgagatc     2700

aatctcctgc tcaaggagaa ggcgaacgat gtgcatatcc tctccattga ccgcggcgag     2760

cggcatctcg cctactacac cctggtcgat ggcaagggca atatcattaa gcaggatacc     2820

ttcaacatca ttggcaatga ccgcatgaaa accaactacc acgataagct cgccgcgatc     2880

gagaaggata gggacagcgc gcgcaaggac tggaagaaga tcaacaatat taaggagatg     2940

aaggagggct acctctcaca ggtggtccat gagattgcca agctcgtgat cgagtacaat     3000

gcgattgtgg tgttcgagga cctcaacttc ggcttcaagc ggggcaggtt caaggtggag     3060

aagcaggtct accagaagct ggagaagatg ctcatcgaga agctcaatta cctggtgttc     3120

aaggataacg agttcgacaa gaccggagga gtcctcaggg cataccagct gaccgcgcca     3180

ttcgagacat tcaagaagat gggcaagcag acaggcatca tctactacgt gccagccggc     3240

ttcacctcca agatctgccc tgtgacaggc ttcgtcaacc agctctaccc taagtacgag     3300

tccgtcagca agtcacagga gttcttcagc aagttcgata agatttgcta caatctggac     3360

aagggctact tcgagttctc attcgattac aagaacttcg gcgacaaggc cgcgaagggc     3420

aagtggacca ttgcgtcttt cggctcccgg ctcatcaact tcaggaatag cgataagaac     3480

cacaattggg acaccaggga ggtgtacccg acaaaggagc tggagaagct gctcaaggac     3540

tactcaatcg agtacggcca tggcgagtgc attaaggccg cgatctgcgg cgagagcgat     3600

aagaagttct tcgccaagct gacctcagtc ctcaatacaa tcctgcagat gaggaactct     3660

aagaccggca cagagctgga ctacctgatt tccccagtgg ccgatgtcaa cggcaatttc     3720

ttcgacagcc gccaggcgcc gaagaatatg ccacaggacg ccgacgccaa cggcgcatac     3780

cacatcggcc tcaagggcct gatgctgctc ggacgcatta agaacaatca ggagggcaag     3840

aagctcaacc tcgtgatcaa gaacgaggag tacttcgagt tcgtccaaaa ccggaacaat     3900

tccggcggca gcccaaagaa gaagaggaag gtgagcggcg gcagcccaaa gaagaagcgc     3960

aaggtctag                                                             3969


<210>  7
<211>  3753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LBCPF1-2NLS

<400>  7
atgtcaaagc tcgagaaatt caccaactgt tattcgttga gcaaaacact gcggtttaaa       60

gcgattccag tcggcaagac tcaagagaat atagacaata agcggctgtt ggtggaagat      120

gaaaagcgcg cggaagacta caaaggggtg aagaagttgt tggacagata ctacctctct      180

tttatcaatg atgtcttgca ctcaatcaaa ttgaagaatc tgaacaacta catctccctc      240

ttcagaaaga aaacaaggac agaaaaggag aataaggaac ttgaaaattt ggagatcaat      300

ctgaggaaag agatcgcgaa agcctttaaa ggcaacgaag gatacaaaag tctgttcaag      360

aaggatataa ttgagacaat tttgccagag ttcctcgatg acaaggacga gattgcgctg      420

gtcaattcgt tcaacggatt cacaacagca ttcacaggct tctttgataa tcgggaaaat      480

atgttctctg aggaggcaaa gtccacttct attgcgttca ggtgtatcaa tgagaatctc      540

actaggtaca tttccaacat ggatatcttt gagaaggttg acgcaatttt tgacaagcac      600

gaagttcagg agattaagga gaagatcctc aattccgatt atgacgttga ggacttcttc      660

gaaggtgagt tttttaattt cgtgctcact caagagggta tcgacgtgta taatgcgatc      720

atcggtgggt tcgtgactga gtccggtgaa aagattaagg gattgaacga gtatatcaac      780

ctttacaacc aaaagacgaa acagaagctg ccaaagttca agcctcttta caaacaggtt      840

ctttcagacc gcgagtcact ctcgttctat ggggagggct acacttcgga tgaggaagtc      900

ctggaggtgt tcaggaatac tctcaataag aattcggaga ttttctcttc tataaaaaaa      960

ctggaaaagt tgtttaagaa ttttgacgaa tactctagcg ccggcatatt tgtgaaaaac     1020

ggcccggcca tatcaacgat aagtaaagat atcttcggcg aatggaacgt gatcagagac     1080

aaatggaacg cggagtatga cgatattcac ctgaagaaga aggctgtcgt aacggagaag     1140

tacgaggatg atcgcaggaa aagcttcaaa aagatcggaa gtttcagcct ggaacagttg     1200

caggagtatg ctgacgccga tcttagcgtc gtcgagaagt tgaaggagat aatcatccaa     1260

aaggtcgacg agatatataa agtctatgga tcaagtgaaa aactgttcga cgccgacttc     1320

gttttggaga agtccctgaa gaagaacgac gctgttgttg ccattatgaa ggatctgctc     1380

gacagcgtga agagtttcga gaactatatt aaggcttttt tcggggaggg gaaggagact     1440

aacagagatg agtccttcta cggagacttc gtcctcgcgt acgatatact ccttaaggta     1500

gaccacatct acgacgcaat cagaaattac gtgacacaaa agccgtacag caaggacaag     1560

ttcaaactct acttccagaa cccccagttc atgggcggct gggacaagga caaggaaacg     1620

gattacaggg ctacgatcct gaggtatggt tcaaaatact acttggcgat tatggacaag     1680

aagtacgcca agtgtctcca gaagattgac aaagacgatg tcaatggcaa ttatgagaag     1740

atcaactaca agctgcttcc gggtccgaac aagatgctcc caaaggtttt cttcagcaag     1800

aaatggatgg cctactataa cccaagcgag gacatccaga agatttataa gaacggtacg     1860

ttcaagaagg gcgacatgtt caatcttaac gactgtcaca agctgatcga cttcttcaaa     1920

gactcaatta gccggtaccc aaagtggtct aacgcctatg acttcaactt ttcggaaacc     1980

gagaagtaca aggatatagc cggattttat agagaggtgg aagagcaggg ctacaaggtg     2040

tcattcgagt ccgccagcaa gaaggaagtg gacaagctcg tggaagaggg taagctctac     2100

atgttccaga tttataataa agactttagc gataagagcc acgggacacc taatctccac     2160

acaatgtatt tcaagctgct cttcgacgag aataaccacg gccaaatcag gttgtcagga     2220

ggggctgaac tcttcatgcg gcgcgctagc cttaagaagg aggagcttgt agtccaccct     2280

gcgaatagtc caattgcgaa taagaacccg gacaatccta aaaagactac aacattgagc     2340

tacgacgtgt acaaggataa gaggttttcc gaggatcagt acgagctcca catcccgatt     2400

gcgatcaaca agtgcccaaa gaatattttc aagataaaca cagaggtgcg tgtactcctg     2460

aagcatgacg acaatcctta cgtcattggg attgatcggg gcgagaggaa cctcctctat     2520

attgtggtgg tggacgggaa ggggaacata gtcgaacagt actcccttaa cgaaataatt     2580

aacaatttca acggcatccg tatcaagacc gactaccatt cgttgctgga caagaaggag     2640

aaggagagat ttgaggcgcg gcaaaattgg acaagtatcg agaacatcaa ggaactcaaa     2700

gcaggttata tctctcaagt tgtgcataag atatgcgagc tggttgagaa gtatgacgca     2760

gtgatcgctc ttgaggacct caactcgggc tttaagaatt ctagagttaa agtggagaag     2820

caggtctatc aaaagttcga gaagatgctt atagataagc tcaactacat ggtcgataag     2880

aaatcgaacc catgtgccac cggcggcgca ctcaaaggtt accaaataac aaacaaattc     2940

gagtccttca aatcgatgag tactcagaat gggttcatat tttatatacc ggcgtggctt     3000

acgtctaaga tcgacccgtc aactggtttt gtcaacctgt tgaagacgaa atacacgtcc     3060

attgccgatt cgaaaaagtt catatctagt tttgatcgta ttatgtacgt cccagaggaa     3120

gatcttttcg agtttgctct cgactacaaa aacttttcgc ggaccgatgc ggattacatt     3180

aaaaaatgga aactctattc gtacggcaac agaatcagga tttttcgcaa ccctaagaag     3240

aataacgtct ttgattggga ggaagtttgc ttgactagcg cgtacaagga gctctttaat     3300

aagtatggca ttaactacca acagggtgat atcagagcac tgctttgcga acaatctgac     3360

aaggctttct actcatcctt catggctttg atgagcctga tgctccagat gagaaattca     3420

attacaggca gaaccgacgt ggatttcttg atctccccgg ttaaaaattc tgatggcatc     3480

ttttacgata gcaggaacta tgaagcgcaa gagaatgcga ttctgccaaa aaatgcagac     3540

gccaacggtg cctataacat cgccaggaaa gtcctgtggg cgatcggcca gttcaaaaag     3600

gccgaagacg aaaaattgga caaggtcaaa atcgctatca gcaacaaaga gtggctggag     3660

tatgctcaga catccgtaaa gcattccggc ggcagcccaa agaagaagag gaaggtgagc     3720

ggcggcagcc caaagaagaa gcgcaaggtc tag                                  3753


<210>  8
<211>  4995
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dFNCPF1-PBE-2NLS

<400>  8
atgccaaaga agaagaggaa ggtttcatcg gagaccggcc ctgttgctgt tgaccccacc       60

ctgcggcgga gaatcgagcc acacgagttc gaggtgttct tcgacccaag ggagctccgc      120

aaggagacgt gcctcctgta cgagatcaac tggggcggca ggcactccat ctggaggcac      180

accagccaaa acaccaacaa gcacgtggag gtcaacttca tcgagaagtt caccaccgag      240

aggtacttct gcccaaacac ccgctgctcc atcacctggt tcctgtcctg gagcccatgc      300

ggcgagtgct ccagggccat caccgagttc ctcagccgct acccacacgt caccctgttc      360

atctacatcg ccaggctcta ccaccacgcc gacccaagga acaggcaggg cctccgcgac      420

ctgatctcca gcggcgtgac catccaaatc atgaccgagc aggagtccgg ctactgctgg      480

aggaacttcg tcaactactc cccaagcaac gaggcccact ggccaaggta cccacacctc      540

tgggtgcgcc tctacgtgct cgagctgtac tgcatcatcc tcggcctgcc accatgcctc      600

aacatcctga ggcgcaagca accacagctg accttcttca ccatcgccct ccaaagctgc      660

cactaccaga ggctcccacc acacatcctg tgggctaccg gcctcaagtc cggcagcgag      720

acgccaggca cctccgagag cgctacgcct gaacttaagt ccatctacca ggagttcgtc      780

aataagtact cactctctaa gaccctgcgg ttcgagctga tcccgcaggg caagacactc      840

gagaacatca aggcgcgcgg cctgattctc gacgatgaga agcgggccaa ggactacaag      900

aaggcgaagc agatcattga taagtaccac cagttcttca tcgaggagat tctgtccagc      960

gtgtgcatct ctgaggatct cctgcagaat tactccgacg tctacttcaa gctcaagaag     1020

tctgacgatg acaacctgca gaaggatttc aagtccgcca aggacaccat caagaagcag     1080

atttctgagt acatcaagga ttccgagaag ttcaagaatc tcttcaacca gaatctgatt     1140

gatgcgaaga agggccagga gtctgacctg atcctctggc tgaagcagtc caaggacaat     1200

ggcattgagc tgttcaaggc caacagcgat atcaccgata ttgacgaggc gctggagatc     1260

attaagtcat tcaagggctg gaccacatac ttcaagggct tccatgagaa ccggaagaat     1320

gtgtactcat ctaacgacat tccgacctcc atcatctaca ggatcgtcga tgacaatctg     1380

ccaaagttcc tcgagaacaa ggccaagtac gagtccctca aggacaaggc cccggaggcg     1440

attaattacg agcagatcaa gaaggatctg gcggaggagc tgaccttcga tatcgactac     1500

aagacaagcg aggtgaacca gagggtgttc tccctcgatg aggtgttcga gatcgccaat     1560

ttcaacaatt acctgaacca gtccggcatt accaagttca atacaatcat tggcggcaag     1620

ttcgtcaacg gcgagaatac caagcgcaag ggcattaacg agtacatcaa tctctactcc     1680

cagcagatca acgacaagac cctgaagaag tacaagatgt ctgtgctctt caagcagatc     1740

ctgtccgata cagagtccaa gagcttcgtc attgataagc tcgaggacga cagcgacgtg     1800

gtcaccacaa tgcagtcatt ctacgagcag atcgccgcgt tcaagaccgt ggaggagaag     1860

agcattaagg agacactctc actcctgttc gatgacctga aggcccagaa gctcgacctg     1920

agcaagatct acttcaagaa cgataagagc ctcacagacc tgtcacagca ggtgttcgat     1980

gactactcag tgattggcac cgccgtcctc gagtacatta cacagcagat cgcgccaaag     2040

aacctcgata atccttctaa gaaggagcag gagctgatcg ccaagaaaac cgagaaggcg     2100

aagtacctct ccctggagac aattaagctc gccctggagg agttcaataa gcacagggat     2160

attgacaagc agtgccgctt cgaggagatc ctcgcgaact tcgccgcgat cccaatgatt     2220

ttcgatgaga tcgcccagaa caaggacaat ctggcgcaga tctctattaa gtaccagaac     2280

cagggcaaga aggacctcct gcaggcctcc gcagaggacg acgtgaaggc catcaaggat     2340

ctcctggacc agaccaacaa tctcctgcac aagctcaaga tcttccatat ttcacagtct     2400

gaggataagg ccaatatcct cgataaggac gagcatttct acctggtgtt cgaggagtgc     2460

tacttcgagc tggcgaacat tgtccctctg tacaacaaga ttaggaatta catcacacag     2520

aagccgtaca gcgacgagaa gttcaagctc aacttcgaga attcaaccct ggccaacggc     2580

tgggataaga ataaggagcc tgacaacaca gcgatcctct tcatcaagga cgacaagtac     2640

tacctgggcg tgatgaataa gaagaacaat aagatcttcg atgacaaggc cattaaggag     2700

aacaagggcg agggctacaa gaagatcgtg tacaagctcc tgcctggcgc caataagatg     2760

ctcccgaagg tgttcttctc cgcgaagtcc attaagttct acaacccaag cgaggatatc     2820

ctcaggatca ggaaccactc tacccataca aagaacggct cccctcagaa gggctacgag     2880

aagttcgagt tcaatatcga ggattgccgg aagttcattg acttctacaa gcagtccatc     2940

agcaagcacc ctgagtggaa ggatttcggc ttccgcttca gcgacaccca gcggtacaac     3000

tcaatcgatg agttctacag ggaggtggag aatcagggct acaagctcac attcgagaac     3060

atttcagagt cttacatcga ctccgtggtc aatcagggca agctctacct gttccagatc     3120

tacaacaagg atttcagcgc ctactcaaag ggcaggccga acctccatac cctgtactgg     3180

aaggcgctct tcgatgagcg caatctgcag gacgtggtct acaagctcaa cggcgaggcc     3240

gagctgttct accgcaagca gtctattccg aagaagatca cacacccagc gaaggaggcc     3300

atcgcgaaca agaataagga caatccgaag aaggagtccg tgttcgagta cgatctcatt     3360

aaggacaagc ggttcaccga ggataagttc ttcttccatt gcccaatcac aattaacttc     3420

aagtccagcg gcgccaacaa gttcaatgac gagatcaatc tcctgctcaa ggagaaggcg     3480

aacgatgtgc atatcctctc cattgcccgc ggcgagcggc atctcgccta ctacaccctg     3540

gtcgatggca agggcaatat cattaagcag gataccttca acatcattgg caatgaccgc     3600

atgaaaacca actaccacga taagctcgcc gcgatcgaga aggataggga cagcgcgcgc     3660

aaggactgga agaagatcaa caatattaag gagatgaagg agggctacct ctcacaggtg     3720

gtccatgaga ttgccaagct cgtgatcgag tacaatgcga ttgtggtgtt cgaggacctc     3780

aacttcggct tcaagcgggg caggttcaag gtggagaagc aggtctacca gaagctggag     3840

aagatgctca tcgagaagct caattacctg gtgttcaagg ataacgagtt cgacaagacc     3900

ggaggagtcc tcagggcata ccagctgacc gcgccattcg agacattcaa gaagatgggc     3960

aagcagacag gcatcatcta ctacgtgcca gccggcttca cctccaagat ctgccctgtg     4020

acaggcttcg tcaaccagct ctaccctaag tacgagtccg tcagcaagtc acaggagttc     4080

ttcagcaagt tcgataagat ttgctacaat ctggacaagg gctacttcga gttctcattc     4140

gattacaaga acttcggcga caaggccgcg aagggcaagt ggaccattgc gtctttcggc     4200

tcccggctca tcaacttcag gaatagcgat aagaaccaca attgggacac cagggaggtg     4260

tacccgacaa aggagctgga gaagctgctc aaggactact caatcgagta cggccatggc     4320

gagtgcatta aggccgcgat ctgcggcgag agcgataaga agttcttcgc caagctgacc     4380

tcagtcctca atacaatcct gcagatgagg aactctaaga ccggcacaga gctggactac     4440

ctgatttccc cagtggccga tgtcaacggc aatttcttcg acagccgcca ggcgccgaag     4500

aatatgccac aggacgccga cgccaacggc gcataccaca tcggcctcaa gggcctgatg     4560

ctgctcggac gcattaagaa caatcaggag ggcaagaagc tcaacctcgt gatcaagaac     4620

gaggagtact tcgagttcgt ccaaaaccgg aacaatacgc gtgactccgg cggcagcacc     4680

aacctgtccg acatcatcga gaaggagacg ggcaagcaac tcgtgatcca ggagagcatc     4740

ctcatgctgc cagaggaggt ggaggaggtc atcggcaaca agccagagtc cgacatcctg     4800

gtgcacaccg cctacgacga gtccaccgac gagaacgtca tgctcctgac cagcgacgcc     4860

ccagagtaca agccatgggc cctcgtcatc caggacagca acggggagaa caagatcaag     4920

atgctgtcgg gggggagccc aaagaagaag cggaaggtga gcggcggcag cccaaagaag     4980

aagcgcaagg tctag                                                      4995


<210>  9
<211>  4779
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dLBCPF1-PBE-2NLS

<400>  9
atgccaaaga agaagaggaa ggtttcatcg gagaccggcc ctgttgctgt tgaccccacc       60

ctgcggcgga gaatcgagcc acacgagttc gaggtgttct tcgacccaag ggagctccgc      120

aaggagacgt gcctcctgta cgagatcaac tggggcggca ggcactccat ctggaggcac      180

accagccaaa acaccaacaa gcacgtggag gtcaacttca tcgagaagtt caccaccgag      240

aggtacttct gcccaaacac ccgctgctcc atcacctggt tcctgtcctg gagcccatgc      300

ggcgagtgct ccagggccat caccgagttc ctcagccgct acccacacgt caccctgttc      360

atctacatcg ccaggctcta ccaccacgcc gacccaagga acaggcaggg cctccgcgac      420

ctgatctcca gcggcgtgac catccaaatc atgaccgagc aggagtccgg ctactgctgg      480

aggaacttcg tcaactactc cccaagcaac gaggcccact ggccaaggta cccacacctc      540

tgggtgcgcc tctacgtgct cgagctgtac tgcatcatcc tcggcctgcc accatgcctc      600

aacatcctga ggcgcaagca accacagctg accttcttca ccatcgccct ccaaagctgc      660

cactaccaga ggctcccacc acacatcctg tgggctaccg gcctcaagtc cggcagcgag      720

acgccaggca cctccgagag cgctacgcct gaacttaagt caaagctcga gaaattcacc      780

aactgttatt cgttgagcaa aacactgcgg tttaaagcga ttccagtcgg caagactcaa      840

gagaatatag acaataagcg gctgttggtg gaagatgaaa agcgcgcgga agactacaaa      900

ggggtgaaga agttgttgga cagatactac ctctctttta tcaatgatgt cttgcactca      960

atcaaattga agaatctgaa caactacatc tccctcttca gaaagaaaac aaggacagaa     1020

aaggagaata aggaacttga aaatttggag atcaatctga ggaaagagat cgcgaaagcc     1080

tttaaaggca acgaaggata caaaagtctg ttcaagaagg atataattga gacaattttg     1140

ccagagttcc tcgatgacaa ggacgagatt gcgctggtca attcgttcaa cggattcaca     1200

acagcattca caggcttctt tgataatcgg gaaaatatgt tctctgagga ggcaaagtcc     1260

acttctattg cgttcaggtg tatcaatgag aatctcacta ggtacatttc caacatggat     1320

atctttgaga aggttgacgc aatttttgac aagcacgaag ttcaggagat taaggagaag     1380

atcctcaatt ccgattatga cgttgaggac ttcttcgaag gtgagttttt taatttcgtg     1440

ctcactcaag agggtatcga cgtgtataat gcgatcatcg gtgggttcgt gactgagtcc     1500

ggtgaaaaga ttaagggatt gaacgagtat atcaaccttt acaaccaaaa gacgaaacag     1560

aagctgccaa agttcaagcc tctttacaaa caggttcttt cagaccgcga gtcactctcg     1620

ttctatgggg agggctacac ttcggatgag gaagtcctgg aggtgttcag gaatactctc     1680

aataagaatt cggagatttt ctcttctata aaaaaactgg aaaagttgtt taagaatttt     1740

gacgaatact ctagcgccgg catatttgtg aaaaacggcc cggccatatc aacgataagt     1800

aaagatatct tcggcgaatg gaacgtgatc agagacaaat ggaacgcgga gtatgacgat     1860

attcacctga agaagaaggc tgtcgtaacg gagaagtacg aggatgatcg caggaaaagc     1920

ttcaaaaaga tcggaagttt cagcctggaa cagttgcagg agtatgctga cgccgatctt     1980

agcgtcgtcg agaagttgaa ggagataatc atccaaaagg tcgacgagat atataaagtc     2040

tatggatcaa gtgaaaaact gttcgacgcc gacttcgttt tggagaagtc cctgaagaag     2100

aacgacgctg ttgttgccat tatgaaggat ctgctcgaca gcgtgaagag tttcgagaac     2160

tatattaagg cttttttcgg ggaggggaag gagactaaca gagatgagtc cttctacgga     2220

gacttcgtcc tcgcgtacga tatactcctt aaggtagacc acatctacga cgcaatcaga     2280

aattacgtga cacaaaagcc gtacagcaag gacaagttca aactctactt ccagaacccc     2340

cagttcatgg gcggctggga caaggacaag gaaacggatt acagggctac gatcctgagg     2400

tatggttcaa aatactactt ggcgattatg gacaagaagt acgccaagtg tctccagaag     2460

attgacaaag acgatgtcaa tggcaattat gagaagatca actacaagct gcttccgggt     2520

ccgaacaaga tgctcccaaa ggttttcttc agcaagaaat ggatggccta ctataaccca     2580

agcgaggaca tccagaagat ttataagaac ggtacgttca agaagggcga catgttcaat     2640

cttaacgact gtcacaagct gatcgacttc ttcaaagact caattagccg gtacccaaag     2700

tggtctaacg cctatgactt caacttttcg gaaaccgaga agtacaagga tatagccgga     2760

ttttatagag aggtggaaga gcagggctac aaggtgtcat tcgagtccgc cagcaagaag     2820

gaagtggaca agctcgtgga agagggtaag ctctacatgt tccagattta taataaagac     2880

tttagcgata agagccacgg gacacctaat ctccacacaa tgtatttcaa gctgctcttc     2940

gacgagaata accacggcca aatcaggttg tcaggagggg ctgaactctt catgcggcgc     3000

gctagcctta agaaggagga gcttgtagtc caccctgcga atagtccaat tgcgaataag     3060

aacccggaca atcctaaaaa gactacaaca ttgagctacg acgtgtacaa ggataagagg     3120

ttttccgagg atcagtacga gctccacatc ccgattgcga tcaacaagtg cccaaagaat     3180

attttcaaga taaacacaga ggtgcgtgta ctcctgaagc atgacgacaa tccttacgtc     3240

attgggattg ctcggggcga gaggaacctc ctctatattg tggtggtgga cgggaagggg     3300

aacatagtcg aacagtactc ccttaacgaa ataattaaca atttcaacgg catccgtatc     3360

aagaccgact accattcgtt gctggacaag aaggagaagg agagatttga ggcgcggcaa     3420

aattggacaa gtatcgagaa catcaaggaa ctcaaagcag gttatatctc tcaagttgtg     3480

cataagatat gcgagctggt tgagaagtat gacgcagtga tcgctcttga ggacctcaac     3540

tcgggcttta agaattctag agttaaagtg gagaagcagg tctatcaaaa gttcgagaag     3600

atgcttatag ataagctcaa ctacatggtc gataagaaat cgaacccatg tgccaccggc     3660

ggcgcactca aaggttacca aataacaaac aaattcgagt ccttcaaatc gatgagtact     3720

cagaatgggt tcatatttta tataccggcg tggcttacgt ctaagatcga cccgtcaact     3780

ggttttgtca acctgttgaa gacgaaatac acgtccattg ccgattcgaa aaagttcata     3840

tctagttttg atcgtattat gtacgtccca gaggaagatc ttttcgagtt tgctctcgac     3900

tacaaaaact tttcgcggac cgatgcggat tacattaaaa aatggaaact ctattcgtac     3960

ggcaacagaa tcaggatttt tcgcaaccct aagaagaata acgtctttga ttgggaggaa     4020

gtttgcttga ctagcgcgta caaggagctc tttaataagt atggcattaa ctaccaacag     4080

ggtgatatca gagcactgct ttgcgaacaa tctgacaagg ctttctactc atccttcatg     4140

gctttgatga gcctgatgct ccagatgaga aattcaatta caggcagaac cgacgtggat     4200

ttcttgatct ccccggttaa aaattctgat ggcatctttt acgatagcag gaactatgaa     4260

gcgcaagaga atgcgattct gccaaaaaat gcagacgcca acggtgccta taacatcgcc     4320

aggaaagtcc tgtgggcgat cggccagttc aaaaaggccg aagacgaaaa attggacaag     4380

gtcaaaatcg ctatcagcaa caaagagtgg ctggagtatg ctcagacatc cgtaaagcat     4440

acgcgtgact ccggcggcag caccaacctg tccgacatca tcgagaagga gacgggcaag     4500

caactcgtga tccaggagag catcctcatg ctgccagagg aggtggagga ggtcatcggc     4560

aacaagccag agtccgacat cctggtgcac accgcctacg acgagtccac cgacgagaac     4620

gtcatgctcc tgaccagcga cgccccagag tacaagccat gggccctcgt catccaggac     4680

agcaacgggg agaacaagat caagatgctg tcggggggga gcccaaagaa gaagcggaag     4740

gtgagcggcg gcagcccaaa gaagaagcgc aaggtctag                            4779


<210>  10
<211>  6305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BDUBI10-dLBCPF1-PBE-2NLS

<400>  10
ctgcagtgca gcgtgacccg gtcgtgcccc tctctagaga taatgagcat tgcatgtcta       60

agttataaaa aattaccaca tatttttttt gtcacacttg tttgaagtgc agtttatcta      120

tctttataca tatatttaaa ctttactcta cgaataatat aatctatagt actacaataa      180

tatcagtgtt ttagagaatc atataaatga acagttagac atggtctaaa ggacaattga      240

gtattttgac aacaggactc tacagtttta tctttttagt gtgcatgtgt tctccttttt      300

ttttgcaaat agcttcacct atataatact tcatccattt tattagtaca tccatttagg      360

gtttagggtt aatggttttt atagactaat ttttttagta catctatttt attctatttt      420

agcctctaaa ttaagaaaac taaaactcta ttttagtttt tttatttaat aatttagata      480

taaaatagaa taaaataaag tgactaaaaa ttaaacaaat accctttaag aaattaaaaa      540

aactaaggaa acatttttct tgtttcgagt agataatgcc agcctgttaa acgccgtcga      600

tcgacgagtc taacggacac caaccagcga accagcagcg tcgcgtcggg ccaagcgaag      660

cagacggcac ggcatctctg tcgctgcctc tggacccctc tcgagagttc cgctccaccg      720

ttggacttgc tccgctgtcg gcatccagaa attgcgtggc ggagcggcag acgtgagccg      780

gcacggcagg cggcctcctc ctcctctcac ggcaccggca gctacggggg attcctttcc      840

caccgctcct tcgctttccc ttcctcgccc gccgtaataa atagacaccc cctccacacc      900

ctctttcccc aacctcgtgt tgttcggagc gcacacacac acaaccagat ctcccccaaa      960

tccacccgtc ggcacctccg cttcaaggta cgccgctcgt cctccccccc cccccctctc     1020

taccttctct agatcggcgt tccggtccat ggttagggcc cggtagttct acttctgttc     1080

atgtttgtgt tagatccgtg tttgtgttag atccgtgctg ctagcgttcg tacacggatg     1140

cgacctgtac gtcagacacg ttctgattgc taacttgcca gtgtttctct ttggggaatc     1200

ctgggatggc tctagccgtt ccgcagacgg gatcgatcta ggataggtat acatgttgat     1260

gtgggtttta ctgatgcata tacatgatgg catatgcagc atctattcat atgctctaac     1320

cttgagtacc tatctattat aataaacaag tatgttttat aattattttg atcttgatat     1380

acttggatga tggcatatgc agcagctata tgtggatttt tttagccctg ccttcatacg     1440

ctatttattt gcttggtact gtttcttttg tcgatgctca ccctgttgtt tggtgttact     1500

tctgcaggtc gaagcttgaa gcaaacatgc caaagaagaa gaggaaggtt tcatcggaga     1560

ccggccctgt tgctgttgac cccaccctgc ggcggagaat cgagccacac gagttcgagg     1620

tgttcttcga cccaagggag ctccgcaagg agacgtgcct cctgtacgag atcaactggg     1680

gcggcaggca ctccatctgg aggcacacca gccaaaacac caacaagcac gtggaggtca     1740

acttcatcga gaagttcacc accgagaggt acttctgccc aaacacccgc tgctccatca     1800

cctggttcct gtcctggagc ccatgcggcg agtgctccag ggccatcacc gagttcctca     1860

gccgctaccc acacgtcacc ctgttcatct acatcgccag gctctaccac cacgccgacc     1920

caaggaacag gcagggcctc cgcgacctga tctccagcgg cgtgaccatc caaatcatga     1980

ccgagcagga gtccggctac tgctggagga acttcgtcaa ctactcccca agcaacgagg     2040

cccactggcc aaggtaccca cacctctggg tgcgcctcta cgtgctcgag ctgtactgca     2100

tcatcctcgg cctgccacca tgcctcaaca tcctgaggcg caagcaacca cagctgacct     2160

tcttcaccat cgccctccaa agctgccact accagaggct cccaccacac atcctgtggg     2220

ctaccggcct caagtccggc agcgagacgc caggcacctc cgagagcgct acgcctgaac     2280

ttaagtcaaa gctcgagaaa ttcaccaact gttattcgtt gagcaaaaca ctgcggttta     2340

aagcgattcc agtcggcaag actcaagaga atatagacaa taagcggctg ttggtggaag     2400

atgaaaagcg cgcggaagac tacaaagggg tgaagaagtt gttggacaga tactacctct     2460

cttttatcaa tgatgtcttg cactcaatca aattgaagaa tctgaacaac tacatctccc     2520

tcttcagaaa gaaaacaagg acagaaaagg agaataagga acttgaaaat ttggagatca     2580

atctgaggaa agagatcgcg aaagccttta aaggcaacga aggatacaaa agtctgttca     2640

agaaggatat aattgagaca attttgccag agttcctcga tgacaaggac gagattgcgc     2700

tggtcaattc gttcaacgga ttcacaacag cattcacagg cttctttgat aatcgggaaa     2760

atatgttctc tgaggaggca aagtccactt ctattgcgtt caggtgtatc aatgagaatc     2820

tcactaggta catttccaac atggatatct ttgagaaggt tgacgcaatt tttgacaagc     2880

acgaagttca ggagattaag gagaagatcc tcaattccga ttatgacgtt gaggacttct     2940

tcgaaggtga gttttttaat ttcgtgctca ctcaagaggg tatcgacgtg tataatgcga     3000

tcatcggtgg gttcgtgact gagtccggtg aaaagattaa gggattgaac gagtatatca     3060

acctttacaa ccaaaagacg aaacagaagc tgccaaagtt caagcctctt tacaaacagg     3120

ttctttcaga ccgcgagtca ctctcgttct atggggaggg ctacacttcg gatgaggaag     3180

tcctggaggt gttcaggaat actctcaata agaattcgga gattttctct tctataaaaa     3240

aactggaaaa gttgtttaag aattttgacg aatactctag cgccggcata tttgtgaaaa     3300

acggcccggc catatcaacg ataagtaaag atatcttcgg cgaatggaac gtgatcagag     3360

acaaatggaa cgcggagtat gacgatattc acctgaagaa gaaggctgtc gtaacggaga     3420

agtacgagga tgatcgcagg aaaagcttca aaaagatcgg aagtttcagc ctggaacagt     3480

tgcaggagta tgctgacgcc gatcttagcg tcgtcgagaa gttgaaggag ataatcatcc     3540

aaaaggtcga cgagatatat aaagtctatg gatcaagtga aaaactgttc gacgccgact     3600

tcgttttgga gaagtccctg aagaagaacg acgctgttgt tgccattatg aaggatctgc     3660

tcgacagcgt gaagagtttc gagaactata ttaaggcttt tttcggggag gggaaggaga     3720

ctaacagaga tgagtccttc tacggagact tcgtcctcgc gtacgatata ctccttaagg     3780

tagaccacat ctacgacgca atcagaaatt acgtgacaca aaagccgtac agcaaggaca     3840

agttcaaact ctacttccag aacccccagt tcatgggcgg ctgggacaag gacaaggaaa     3900

cggattacag ggctacgatc ctgaggtatg gttcaaaata ctacttggcg attatggaca     3960

agaagtacgc caagtgtctc cagaagattg acaaagacga tgtcaatggc aattatgaga     4020

agatcaacta caagctgctt ccgggtccga acaagatgct cccaaaggtt ttcttcagca     4080

agaaatggat ggcctactat aacccaagcg aggacatcca gaagatttat aagaacggta     4140

cgttcaagaa gggcgacatg ttcaatctta acgactgtca caagctgatc gacttcttca     4200

aagactcaat tagccggtac ccaaagtggt ctaacgccta tgacttcaac ttttcggaaa     4260

ccgagaagta caaggatata gccggatttt atagagaggt ggaagagcag ggctacaagg     4320

tgtcattcga gtccgccagc aagaaggaag tggacaagct cgtggaagag ggtaagctct     4380

acatgttcca gatttataat aaagacttta gcgataagag ccacgggaca cctaatctcc     4440

acacaatgta tttcaagctg ctcttcgacg agaataacca cggccaaatc aggttgtcag     4500

gaggggctga actcttcatg cggcgcgcta gccttaagaa ggaggagctt gtagtccacc     4560

ctgcgaatag tccaattgcg aataagaacc cggacaatcc taaaaagact acaacattga     4620

gctacgacgt gtacaaggat aagaggtttt ccgaggatca gtacgagctc cacatcccga     4680

ttgcgatcaa caagtgccca aagaatattt tcaagataaa cacagaggtg cgtgtactcc     4740

tgaagcatga cgacaatcct tacgtcattg ggattgctcg gggcgagagg aacctcctct     4800

atattgtggt ggtggacggg aaggggaaca tagtcgaaca gtactccctt aacgaaataa     4860

ttaacaattt caacggcatc cgtatcaaga ccgactacca ttcgttgctg gacaagaagg     4920

agaaggagag atttgaggcg cggcaaaatt ggacaagtat cgagaacatc aaggaactca     4980

aagcaggtta tatctctcaa gttgtgcata agatatgcga gctggttgag aagtatgacg     5040

cagtgatcgc tcttgaggac ctcaactcgg gctttaagaa ttctagagtt aaagtggaga     5100

agcaggtcta tcaaaagttc gagaagatgc ttatagataa gctcaactac atggtcgata     5160

agaaatcgaa cccatgtgcc accggcggcg cactcaaagg ttaccaaata acaaacaaat     5220

tcgagtcctt caaatcgatg agtactcaga atgggttcat attttatata ccggcgtggc     5280

ttacgtctaa gatcgacccg tcaactggtt ttgtcaacct gttgaagacg aaatacacgt     5340

ccattgccga ttcgaaaaag ttcatatcta gttttgatcg tattatgtac gtcccagagg     5400

aagatctttt cgagtttgct ctcgactaca aaaacttttc gcggaccgat gcggattaca     5460

ttaaaaaatg gaaactctat tcgtacggca acagaatcag gatttttcgc aaccctaaga     5520

agaataacgt ctttgattgg gaggaagttt gcttgactag cgcgtacaag gagctcttta     5580

ataagtatgg cattaactac caacagggtg atatcagagc actgctttgc gaacaatctg     5640

acaaggcttt ctactcatcc ttcatggctt tgatgagcct gatgctccag atgagaaatt     5700

caattacagg cagaaccgac gtggatttct tgatctcccc ggttaaaaat tctgatggca     5760

tcttttacga tagcaggaac tatgaagcgc aagagaatgc gattctgcca aaaaatgcag     5820

acgccaacgg tgcctataac atcgccagga aagtcctgtg ggcgatcggc cagttcaaaa     5880

aggccgaaga cgaaaaattg gacaaggtca aaatcgctat cagcaacaaa gagtggctgg     5940

agtatgctca gacatccgta aagcatacgc gtgactccgg cggcagcacc aacctgtccg     6000

acatcatcga gaaggagacg ggcaagcaac tcgtgatcca ggagagcatc ctcatgctgc     6060

cagaggaggt ggaggaggtc atcggcaaca agccagagtc cgacatcctg gtgcacaccg     6120

cctacgacga gtccaccgac gagaacgtca tgctcctgac cagcgacgcc ccagagtaca     6180

agccatgggc cctcgtcatc caggacagca acggggagaa caagatcaag atgctgtcgg     6240

gggggagccc aaagaagaag cggaaggtga gcggcggcag cccaaagaag aagcgcaagg     6300

tctag                                                                 6305


<210>  11
<211>  5196
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dFNCPF1-ABE7.10-2NLS

<400>  11
atgccaaaaa agaagagaaa ggtttcaggc ggctcctccg aggtggagtt ctctcacgag       60

tattggatga ggcacgctct tacacttgct aagagagctt gggacgaaag agaagtgcca      120

gttggcgccg ttcttgtgca taataatagg gtgatcggcg agggttggaa tagaccaatt      180

ggaaggcatg atccaacagc tcacgcagag attatggctc tcagacaagg cggcctcgtt      240

atgcagaact acaggctcat tgacgctaca ctctacgtga cactcgaacc ttgcgttatg      300

tgcgccggag ctatgattca ttctaggatt ggcagggtcg tgtttggagc tagggacgct      360

aaaacaggag ccgccggatc tcttatggac gtgttgcatc atccaggcat gaaccatagg      420

gtggagatta cagagggcat tcttgcagac gagtgcgctg ctcttctttc cgatttcttc      480

aggatgagaa ggcaggagat taaggcccag aagaaggctc agtcttctac agatagcgga      540

ggatcttccg gaggatctag cggctccgag acaccaggaa catccgaaag cgctacacca      600

gaatctagcg gaggctcttc cggaggatct tctgaagtgg agttctccca cgagtattgg      660

atgaggcacg ctcttacact tgctaaaagg gctagggacg aaagggaagt tccagttgga      720

gctgttctcg tgctcaataa cagggtgatt ggcgagggtt ggaatagagc cattggactc      780

catgatccaa cagctcacgc agagattatg gctcttagac aaggcggcct cgttatgcag      840

aattacagac tcatcgacgc cacactctac gttaccttcg aaccttgcgt tatgtgcgcc      900

ggagctatga tccattctag gattggcagg gtcgtgttcg gcgttagaaa cgctaagaca      960

ggagctgcag gctctcttat ggacgttctt cattacccag gcatgaatca tagagtggag     1020

atcacagaag gcattcttgc agacgagtgc gcagctctcc tttgctattt cttcaggatg     1080

ccgaggcaag ttttcaacgc tcagaagaag gcccagtctt ctacagattc cggcggatct     1140

tctggaggat ctagcggctc cgagacacca ggaacatccg aatccgctac accagagtct     1200

tctggaggat ctagcggagg atctcttaag tccatctacc aggagttcgt caataagtac     1260

tcactctcta agaccctgcg gttcgagctg atcccgcagg gcaagacact cgagaacatc     1320

aaggcgcgcg gcctgattct cgacgatgag aagcgggcca aggactacaa gaaggcgaag     1380

cagatcattg ataagtacca ccagttcttc atcgaggaga ttctgtccag cgtgtgcatc     1440

tctgaggatc tcctgcagaa ttactccgac gtctacttca agctcaagaa gtctgacgat     1500

gacaacctgc agaaggattt caagtccgcc aaggacacca tcaagaagca gatttctgag     1560

tacatcaagg attccgagaa gttcaagaat ctcttcaacc agaatctgat tgatgcgaag     1620

aagggccagg agtctgacct gatcctctgg ctgaagcagt ccaaggacaa tggcattgag     1680

ctgttcaagg ccaacagcga tatcaccgat attgacgagg cgctggagat cattaagtca     1740

ttcaagggct ggaccacata cttcaagggc ttccatgaga accggaagaa tgtgtactca     1800

tctaacgaca ttccgacctc catcatctac aggatcgtcg atgacaatct gccaaagttc     1860

ctcgagaaca aggccaagta cgagtccctc aaggacaagg ccccggaggc gattaattac     1920

gagcagatca agaaggatct ggcggaggag ctgaccttcg atatcgacta caagacaagc     1980

gaggtgaacc agagggtgtt ctccctcgat gaggtgttcg agatcgccaa tttcaacaat     2040

tacctgaacc agtccggcat taccaagttc aatacaatca ttggcggcaa gttcgtcaac     2100

ggcgagaata ccaagcgcaa gggcattaac gagtacatca atctctactc ccagcagatc     2160

aacgacaaga ccctgaagaa gtacaagatg tctgtgctct tcaagcagat cctgtccgat     2220

acagagtcca agagcttcgt cattgataag ctcgaggacg acagcgacgt ggtcaccaca     2280

atgcagtcat tctacgagca gatcgccgcg ttcaagaccg tggaggagaa gagcattaag     2340

gagacactct cactcctgtt cgatgacctg aaggcccaga agctcgacct gagcaagatc     2400

tacttcaaga acgataagag cctcacagac ctgtcacagc aggtgttcga tgactactca     2460

gtgattggca ccgccgtcct cgagtacatt acacagcaga tcgcgccaaa gaacctcgat     2520

aatccttcta agaaggagca ggagctgatc gccaagaaaa ccgagaaggc gaagtacctc     2580

tccctggaga caattaagct cgccctggag gagttcaata agcacaggga tattgacaag     2640

cagtgccgct tcgaggagat cctcgcgaac ttcgccgcga tcccaatgat tttcgatgag     2700

atcgcccaga acaaggacaa tctggcgcag atctctatta agtaccagaa ccagggcaag     2760

aaggacctcc tgcaggcctc cgcagaggac gacgtgaagg ccatcaagga tctcctggac     2820

cagaccaaca atctcctgca caagctcaag atcttccata tttcacagtc tgaggataag     2880

gccaatatcc tcgataagga cgagcatttc tacctggtgt tcgaggagtg ctacttcgag     2940

ctggcgaaca ttgtccctct gtacaacaag attaggaatt acatcacaca gaagccgtac     3000

agcgacgaga agttcaagct caacttcgag aattcaaccc tggccaacgg ctgggataag     3060

aataaggagc ctgacaacac agcgatcctc ttcatcaagg acgacaagta ctacctgggc     3120

gtgatgaata agaagaacaa taagatcttc gatgacaagg ccattaagga gaacaagggc     3180

gagggctaca agaagatcgt gtacaagctc ctgcctggcg ccaataagat gctcccgaag     3240

gtgttcttct ccgcgaagtc cattaagttc tacaacccaa gcgaggatat cctcaggatc     3300

aggaaccact ctacccatac aaagaacggc tcccctcaga agggctacga gaagttcgag     3360

ttcaatatcg aggattgccg gaagttcatt gacttctaca agcagtccat cagcaagcac     3420

cctgagtgga aggatttcgg cttccgcttc agcgacaccc agcggtacaa ctcaatcgat     3480

gagttctaca gggaggtgga gaatcagggc tacaagctca cattcgagaa catttcagag     3540

tcttacatcg actccgtggt caatcagggc aagctctacc tgttccagat ctacaacaag     3600

gatttcagcg cctactcaaa gggcaggccg aacctccata ccctgtactg gaaggcgctc     3660

ttcgatgagc gcaatctgca ggacgtggtc tacaagctca acggcgaggc cgagctgttc     3720

taccgcaagc agtctattcc gaagaagatc acacacccag cgaaggaggc catcgcgaac     3780

aagaataagg acaatccgaa gaaggagtcc gtgttcgagt acgatctcat taaggacaag     3840

cggttcaccg aggataagtt cttcttccat tgcccaatca caattaactt caagtccagc     3900

ggcgccaaca agttcaatga cgagatcaat ctcctgctca aggagaaggc gaacgatgtg     3960

catatcctct ccattgcccg cggcgagcgg catctcgcct actacaccct ggtcgatggc     4020

aagggcaata tcattaagca ggataccttc aacatcattg gcaatgaccg catgaaaacc     4080

aactaccacg ataagctcgc cgcgatcgag aaggataggg acagcgcgcg caaggactgg     4140

aagaagatca acaatattaa ggagatgaag gagggctacc tctcacaggt ggtccatgag     4200

attgccaagc tcgtgatcga gtacaatgcg attgtggtgt tcgaggacct caacttcggc     4260

ttcaagcggg gcaggttcaa ggtggagaag caggtctacc agaagctgga gaagatgctc     4320

atcgagaagc tcaattacct ggtgttcaag gataacgagt tcgacaagac cggaggagtc     4380

ctcagggcat accagctgac cgcgccattc gagacattca agaagatggg caagcagaca     4440

ggcatcatct actacgtgcc agccggcttc acctccaaga tctgccctgt gacaggcttc     4500

gtcaaccagc tctaccctaa gtacgagtcc gtcagcaagt cacaggagtt cttcagcaag     4560

ttcgataaga tttgctacaa tctggacaag ggctacttcg agttctcatt cgattacaag     4620

aacttcggcg acaaggccgc gaagggcaag tggaccattg cgtctttcgg ctcccggctc     4680

atcaacttca ggaatagcga taagaaccac aattgggaca ccagggaggt gtacccgaca     4740

aaggagctgg agaagctgct caaggactac tcaatcgagt acggccatgg cgagtgcatt     4800

aaggccgcga tctgcggcga gagcgataag aagttcttcg ccaagctgac ctcagtcctc     4860

aatacaatcc tgcagatgag gaactctaag accggcacag agctggacta cctgatttcc     4920

ccagtggccg atgtcaacgg caatttcttc gacagccgcc aggcgccgaa gaatatgcca     4980

caggacgccg acgccaacgg cgcataccac atcggcctca agggcctgat gctgctcgga     5040

cgcattaaga acaatcagga gggcaagaag ctcaacctcg tgatcaagaa cgaggagtac     5100

ttcgagttcg tccaaaaccg gaacaattcc ggcggcagcc caaagaagaa gaggaaggtg     5160

agcggcggca gcccaaagaa gaagcgcaag gtctag                               5196


<210>  12
<211>  4980
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dLBCPF1-ABE7.10-2NLS

<400>  12
atgccaaaaa agaagagaaa ggtttcaggc ggctcctccg aggtggagtt ctctcacgag       60

tattggatga ggcacgctct tacacttgct aagagagctt gggacgaaag agaagtgcca      120

gttggcgccg ttcttgtgca taataatagg gtgatcggcg agggttggaa tagaccaatt      180

ggaaggcatg atccaacagc tcacgcagag attatggctc tcagacaagg cggcctcgtt      240

atgcagaact acaggctcat tgacgctaca ctctacgtga cactcgaacc ttgcgttatg      300

tgcgccggag ctatgattca ttctaggatt ggcagggtcg tgtttggagc tagggacgct      360

aaaacaggag ccgccggatc tcttatggac gtgttgcatc atccaggcat gaaccatagg      420

gtggagatta cagagggcat tcttgcagac gagtgcgctg ctcttctttc cgatttcttc      480

aggatgagaa ggcaggagat taaggcccag aagaaggctc agtcttctac agatagcgga      540

ggatcttccg gaggatctag cggctccgag acaccaggaa catccgaaag cgctacacca      600

gaatctagcg gaggctcttc cggaggatct tctgaagtgg agttctccca cgagtattgg      660

atgaggcacg ctcttacact tgctaaaagg gctagggacg aaagggaagt tccagttgga      720

gctgttctcg tgctcaataa cagggtgatt ggcgagggtt ggaatagagc cattggactc      780

catgatccaa cagctcacgc agagattatg gctcttagac aaggcggcct cgttatgcag      840

aattacagac tcatcgacgc cacactctac gttaccttcg aaccttgcgt tatgtgcgcc      900

ggagctatga tccattctag gattggcagg gtcgtgttcg gcgttagaaa cgctaagaca      960

ggagctgcag gctctcttat ggacgttctt cattacccag gcatgaatca tagagtggag     1020

atcacagaag gcattcttgc agacgagtgc gcagctctcc tttgctattt cttcaggatg     1080

ccgaggcaag ttttcaacgc tcagaagaag gcccagtctt ctacagattc cggcggatct     1140

tctggaggat ctagcggctc cgagacacca ggaacatccg aatccgctac accagagtct     1200

tctggaggat ctagcggagg atctcttaag tcaaagctcg agaaattcac caactgttat     1260

tcgttgagca aaacactgcg gtttaaagcg attccagtcg gcaagactca agagaatata     1320

gacaataagc ggctgttggt ggaagatgaa aagcgcgcgg aagactacaa aggggtgaag     1380

aagttgttgg acagatacta cctctctttt atcaatgatg tcttgcactc aatcaaattg     1440

aagaatctga acaactacat ctccctcttc agaaagaaaa caaggacaga aaaggagaat     1500

aaggaacttg aaaatttgga gatcaatctg aggaaagaga tcgcgaaagc ctttaaaggc     1560

aacgaaggat acaaaagtct gttcaagaag gatataattg agacaatttt gccagagttc     1620

ctcgatgaca aggacgagat tgcgctggtc aattcgttca acggattcac aacagcattc     1680

acaggcttct ttgataatcg ggaaaatatg ttctctgagg aggcaaagtc cacttctatt     1740

gcgttcaggt gtatcaatga gaatctcact aggtacattt ccaacatgga tatctttgag     1800

aaggttgacg caatttttga caagcacgaa gttcaggaga ttaaggagaa gatcctcaat     1860

tccgattatg acgttgagga cttcttcgaa ggtgagtttt ttaatttcgt gctcactcaa     1920

gagggtatcg acgtgtataa tgcgatcatc ggtgggttcg tgactgagtc cggtgaaaag     1980

attaagggat tgaacgagta tatcaacctt tacaaccaaa agacgaaaca gaagctgcca     2040

aagttcaagc ctctttacaa acaggttctt tcagaccgcg agtcactctc gttctatggg     2100

gagggctaca cttcggatga ggaagtcctg gaggtgttca ggaatactct caataagaat     2160

tcggagattt tctcttctat aaaaaaactg gaaaagttgt ttaagaattt tgacgaatac     2220

tctagcgccg gcatatttgt gaaaaacggc ccggccatat caacgataag taaagatatc     2280

ttcggcgaat ggaacgtgat cagagacaaa tggaacgcgg agtatgacga tattcacctg     2340

aagaagaagg ctgtcgtaac ggagaagtac gaggatgatc gcaggaaaag cttcaaaaag     2400

atcggaagtt tcagcctgga acagttgcag gagtatgctg acgccgatct tagcgtcgtc     2460

gagaagttga aggagataat catccaaaag gtcgacgaga tatataaagt ctatggatca     2520

agtgaaaaac tgttcgacgc cgacttcgtt ttggagaagt ccctgaagaa gaacgacgct     2580

gttgttgcca ttatgaagga tctgctcgac agcgtgaaga gtttcgagaa ctatattaag     2640

gcttttttcg gggaggggaa ggagactaac agagatgagt ccttctacgg agacttcgtc     2700

ctcgcgtacg atatactcct taaggtagac cacatctacg acgcaatcag aaattacgtg     2760

acacaaaagc cgtacagcaa ggacaagttc aaactctact tccagaaccc ccagttcatg     2820

ggcggctggg acaaggacaa ggaaacggat tacagggcta cgatcctgag gtatggttca     2880

aaatactact tggcgattat ggacaagaag tacgccaagt gtctccagaa gattgacaaa     2940

gacgatgtca atggcaatta tgagaagatc aactacaagc tgcttccggg tccgaacaag     3000

atgctcccaa aggttttctt cagcaagaaa tggatggcct actataaccc aagcgaggac     3060

atccagaaga tttataagaa cggtacgttc aagaagggcg acatgttcaa tcttaacgac     3120

tgtcacaagc tgatcgactt cttcaaagac tcaattagcc ggtacccaaa gtggtctaac     3180

gcctatgact tcaacttttc ggaaaccgag aagtacaagg atatagccgg attttataga     3240

gaggtggaag agcagggcta caaggtgtca ttcgagtccg ccagcaagaa ggaagtggac     3300

aagctcgtgg aagagggtaa gctctacatg ttccagattt ataataaaga ctttagcgat     3360

aagagccacg ggacacctaa tctccacaca atgtatttca agctgctctt cgacgagaat     3420

aaccacggcc aaatcaggtt gtcaggaggg gctgaactct tcatgcggcg cgctagcctt     3480

aagaaggagg agcttgtagt ccaccctgcg aatagtccaa ttgcgaataa gaacccggac     3540

aatcctaaaa agactacaac attgagctac gacgtgtaca aggataagag gttttccgag     3600

gatcagtacg agctccacat cccgattgcg atcaacaagt gcccaaagaa tattttcaag     3660

ataaacacag aggtgcgtgt actcctgaag catgacgaca atccttacgt cattgggatt     3720

gctcggggcg agaggaacct cctctatatt gtggtggtgg acgggaaggg gaacatagtc     3780

gaacagtact cccttaacga aataattaac aatttcaacg gcatccgtat caagaccgac     3840

taccattcgt tgctggacaa gaaggagaag gagagatttg aggcgcggca aaattggaca     3900

agtatcgaga acatcaagga actcaaagca ggttatatct ctcaagttgt gcataagata     3960

tgcgagctgg ttgagaagta tgacgcagtg atcgctcttg aggacctcaa ctcgggcttt     4020

aagaattcta gagttaaagt ggagaagcag gtctatcaaa agttcgagaa gatgcttata     4080

gataagctca actacatggt cgataagaaa tcgaacccat gtgccaccgg cggcgcactc     4140

aaaggttacc aaataacaaa caaattcgag tccttcaaat cgatgagtac tcagaatggg     4200

ttcatatttt atataccggc gtggcttacg tctaagatcg acccgtcaac tggttttgtc     4260

aacctgttga agacgaaata cacgtccatt gccgattcga aaaagttcat atctagtttt     4320

gatcgtatta tgtacgtccc agaggaagat cttttcgagt ttgctctcga ctacaaaaac     4380

ttttcgcgga ccgatgcgga ttacattaaa aaatggaaac tctattcgta cggcaacaga     4440

atcaggattt ttcgcaaccc taagaagaat aacgtctttg attgggagga agtttgcttg     4500

actagcgcgt acaaggagct ctttaataag tatggcatta actaccaaca gggtgatatc     4560

agagcactgc tttgcgaaca atctgacaag gctttctact catccttcat ggctttgatg     4620

agcctgatgc tccagatgag aaattcaatt acaggcagaa ccgacgtgga tttcttgatc     4680

tccccggtta aaaattctga tggcatcttt tacgatagca ggaactatga agcgcaagag     4740

aatgcgattc tgccaaaaaa tgcagacgcc aacggtgcct ataacatcgc caggaaagtc     4800

ctgtgggcga tcggccagtt caaaaaggcc gaagacgaaa aattggacaa ggtcaaaatc     4860

gctatcagca acaaagagtg gctggagtat gctcagacat ccgtaaagca ttccggcggc     4920

agcccaaaga agaagaggaa ggtgagcggc ggcagcccaa agaagaagcg caaggtctag     4980


<210>  13
<211>  6506
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  dLBCPF1-ABE2-X

<400>  13
ctgcagtgca gcgtgacccg gtcgtgcccc tctctagaga taatgagcat tgcatgtcta       60

agttataaaa aattaccaca tatttttttt gtcacacttg tttgaagtgc agtttatcta      120

tctttataca tatatttaaa ctttactcta cgaataatat aatctatagt actacaataa      180

tatcagtgtt ttagagaatc atataaatga acagttagac atggtctaaa ggacaattga      240

gtattttgac aacaggactc tacagtttta tctttttagt gtgcatgtgt tctccttttt      300

ttttgcaaat agcttcacct atataatact tcatccattt tattagtaca tccatttagg      360

gtttagggtt aatggttttt atagactaat ttttttagta catctatttt attctatttt      420

agcctctaaa ttaagaaaac taaaactcta ttttagtttt tttatttaat aatttagata      480

taaaatagaa taaaataaag tgactaaaaa ttaaacaaat accctttaag aaattaaaaa      540

aactaaggaa acatttttct tgtttcgagt agataatgcc agcctgttaa acgccgtcga      600

tcgacgagtc taacggacac caaccagcga accagcagcg tcgcgtcggg ccaagcgaag      660

cagacggcac ggcatctctg tcgctgcctc tggacccctc tcgagagttc cgctccaccg      720

ttggacttgc tccgctgtcg gcatccagaa attgcgtggc ggagcggcag acgtgagccg      780

gcacggcagg cggcctcctc ctcctctcac ggcaccggca gctacggggg attcctttcc      840

caccgctcct tcgctttccc ttcctcgccc gccgtaataa atagacaccc cctccacacc      900

ctctttcccc aacctcgtgt tgttcggagc gcacacacac acaaccagat ctcccccaaa      960

tccacccgtc ggcacctccg cttcaaggta cgccgctcgt cctccccccc cccccctctc     1020

taccttctct agatcggcgt tccggtccat ggttagggcc cggtagttct acttctgttc     1080

atgtttgtgt tagatccgtg tttgtgttag atccgtgctg ctagcgttcg tacacggatg     1140

cgacctgtac gtcagacacg ttctgattgc taacttgcca gtgtttctct ttggggaatc     1200

ctgggatggc tctagccgtt ccgcagacgg gatcgatcta ggataggtat acatgttgat     1260

gtgggtttta ctgatgcata tacatgatgg catatgcagc atctattcat atgctctaac     1320

cttgagtacc tatctattat aataaacaag tatgttttat aattattttg atcttgatat     1380

acttggatga tggcatatgc agcagctata tgtggatttt tttagccctg ccttcatacg     1440

ctatttattt gcttggtact gtttcttttg tcgatgctca ccctgttgtt tggtgttact     1500

tctgcaggtc gaagcttgaa gcaaacatgc caaaaaagaa gagaaaggtt tcaggcggct     1560

cctccgaggt ggagttctct cacgagtatt ggatgaggca cgctcttaca cttgctaaga     1620

gagcttggga cgaaagagaa gtgccagttg gcgccgttct tgtgcataat aatagggtga     1680

tcggcgaggg ttggaataga ccaattggaa ggcatgatcc aacagctcac gcagagatta     1740

tggctctcag acaaggcggc ctcgttatgc agaactacag gctcattgac gctacactct     1800

acgtgacact cgaaccttgc gttatgtgcg ccggagctat gattcattct aggattggca     1860

gggtcgtgtt tggagctagg gacgctaaaa caggagccgc cggatctctt atggacgtgt     1920

tgcatcatcc aggcatgaac catagggtgg agattacaga gggcattctt gcagacgagt     1980

gcgctgctct tctttccgat ttcttcagga tgagaaggca ggagattaag gcccagaaga     2040

aggctcagtc ttctacagat agcggaggat cttccggagg atctagcggc tccgagacac     2100

caggaacatc cgaaagcgct acaccagaat ctagcggagg ctcttccgga ggatcttctg     2160

aagtggagtt ctcccacgag tattggatga ggcacgctct tacacttgct aaaagggcta     2220

gggacgaaag ggaagttcca gttggagctg ttctcgtgct caataacagg gtgattggcg     2280

agggttggaa tagagccatt ggactccatg atccaacagc tcacgcagag attatggctc     2340

ttagacaagg cggcctcgtt atgcagaatt acagactcat cgacgccaca ctctacgtta     2400

ccttcgaacc ttgcgttatg tgcgccggag ctatgatcca ttctaggatt ggcagggtcg     2460

tgttcggcgt tagaaacgct aagacaggag ctgcaggctc tcttatggac gttcttcatt     2520

acccaggcat gaatcataga gtggagatca cagaaggcat tcttgcagac gagtgcgcag     2580

ctctcctttg ctatttcttc aggatgccga ggcaagtttt caacgctcag aagaaggccc     2640

agtcttctac agattccggc ggatcttctg gaggatctag cggctccgag acaccaggaa     2700

catccgaatc cgctacacca gagtcttctg gaggatctag cggaggatct cttaagtcaa     2760

agctcgagaa attcaccaac tgttattcgt tgagcaaaac actgcggttt aaagcgattc     2820

cagtcggcaa gactcaagag aatatagaca ataagcggct gttggtggaa gatgaaaagc     2880

gcgcggaaga ctacaaaggg gtgaagaagt tgttggacag atactacctc tcttttatca     2940

atgatgtctt gcactcaatc aaattgaaga atctgaacaa ctacatctcc ctcttcagaa     3000

agaaaacaag gacagaaaag gagaataagg aacttgaaaa tttggagatc aatctgagga     3060

aagagatcgc gaaagccttt aaaggcaacg aaggatacaa aagtctgttc aagaaggata     3120

taattgagac aattttgcca gagttcctcg atgacaagga cgagattgcg ctggtcaatt     3180

cgttcaacgg attcacaaca gcattcacag gcttctttga taatcgggaa aatatgttct     3240

ctgaggaggc aaagtccact tctattgcgt tcaggtgtat caatgagaat ctcactaggt     3300

acatttccaa catggatatc tttgagaagg ttgacgcaat ttttgacaag cacgaagttc     3360

aggagattaa ggagaagatc ctcaattccg attatgacgt tgaggacttc ttcgaaggtg     3420

agttttttaa tttcgtgctc actcaagagg gtatcgacgt gtataatgcg atcatcggtg     3480

ggttcgtgac tgagtccggt gaaaagatta agggattgaa cgagtatatc aacctttaca     3540

accaaaagac gaaacagaag ctgccaaagt tcaagcctct ttacaaacag gttctttcag     3600

accgcgagtc actctcgttc tatggggagg gctacacttc ggatgaggaa gtcctggagg     3660

tgttcaggaa tactctcaat aagaattcgg agattttctc ttctataaaa aaactggaaa     3720

agttgtttaa gaattttgac gaatactcta gcgccggcat atttgtgaaa aacggcccgg     3780

ccatatcaac gataagtaaa gatatcttcg gcgaatggaa cgtgatcaga gacaaatgga     3840

acgcggagta tgacgatatt cacctgaaga agaaggctgt cgtaacggag aagtacgagg     3900

atgatcgcag gaaaagcttc aaaaagatcg gaagtttcag cctggaacag ttgcaggagt     3960

atgctgacgc cgatcttagc gtcgtcgaga agttgaagga gataatcatc caaaaggtcg     4020

acgagatata taaagtctat ggatcaagtg aaaaactgtt cgacgccgac ttcgttttgg     4080

agaagtccct gaagaagaac gacgctgttg ttgccattat gaaggatctg ctcgacagcg     4140

tgaagagttt cgagaactat attaaggctt ttttcgggga ggggaaggag actaacagag     4200

atgagtcctt ctacggagac ttcgtcctcg cgtacgatat actccttaag gtagaccaca     4260

tctacgacgc aatcagaaat tacgtgacac aaaagccgta cagcaaggac aagttcaaac     4320

tctacttcca gaacccccag ttcatgggcg gctgggacaa ggacaaggaa acggattaca     4380

gggctacgat cctgaggtat ggttcaaaat actacttggc gattatggac aagaagtacg     4440

ccaagtgtct ccagaagatt gacaaagacg atgtcaatgg caattatgag aagatcaact     4500

acaagctgct tccgggtccg aacaagatgc tcccaaaggt tttcttcagc aagaaatgga     4560

tggcctacta taacccaagc gaggacatcc agaagattta taagaacggt acgttcaaga     4620

agggcgacat gttcaatctt aacgactgtc acaagctgat cgacttcttc aaagactcaa     4680

ttagccggta cccaaagtgg tctaacgcct atgacttcaa cttttcggaa accgagaagt     4740

acaaggatat agccggattt tatagagagg tggaagagca gggctacaag gtgtcattcg     4800

agtccgccag caagaaggaa gtggacaagc tcgtggaaga gggtaagctc tacatgttcc     4860

agatttataa taaagacttt agcgataaga gccacgggac acctaatctc cacacaatgt     4920

atttcaagct gctcttcgac gagaataacc acggccaaat caggttgtca ggaggggctg     4980

aactcttcat gcggcgcgct agccttaaga aggaggagct tgtagtccac cctgcgaata     5040

gtccaattgc gaataagaac ccggacaatc ctaaaaagac tacaacattg agctacgacg     5100

tgtacaagga taagaggttt tccgaggatc agtacgagct ccacatcccg attgcgatca     5160

acaagtgccc aaagaatatt ttcaagataa acacagaggt gcgtgtactc ctgaagcatg     5220

acgacaatcc ttacgtcatt gggattgctc ggggcgagag gaacctcctc tatattgtgg     5280

tggtggacgg gaaggggaac atagtcgaac agtactccct taacgaaata attaacaatt     5340

tcaacggcat ccgtatcaag accgactacc attcgttgct ggacaagaag gagaaggaga     5400

gatttgaggc gcggcaaaat tggacaagta tcgagaacat caaggaactc aaagcaggtt     5460

atatctctca agttgtgcat aagatatgcg agctggttga gaagtatgac gcagtgatcg     5520

ctcttgagga cctcaactcg ggctttaaga attctagagt taaagtggag aagcaggtct     5580

atcaaaagtt cgagaagatg cttatagata agctcaacta catggtcgat aagaaatcga     5640

acccatgtgc caccggcggc gcactcaaag gttaccaaat aacaaacaaa ttcgagtcct     5700

tcaaatcgat gagtactcag aatgggttca tattttatat accggcgtgg cttacgtcta     5760

agatcgaccc gtcaactggt tttgtcaacc tgttgaagac gaaatacacg tccattgccg     5820

attcgaaaaa gttcatatct agttttgatc gtattatgta cgtcccagag gaagatcttt     5880

tcgagtttgc tctcgactac aaaaactttt cgcggaccga tgcggattac attaaaaaat     5940

ggaaactcta ttcgtacggc aacagaatca ggatttttcg caaccctaag aagaataacg     6000

tctttgattg ggaggaagtt tgcttgacta gcgcgtacaa ggagctcttt aataagtatg     6060

gcattaacta ccaacagggt gatatcagag cactgctttg cgaacaatct gacaaggctt     6120

tctactcatc cttcatggct ttgatgagcc tgatgctcca gatgagaaat tcaattacag     6180

gcagaaccga cgtggatttc ttgatctccc cggttaaaaa ttctgatggc atcttttacg     6240

atagcaggaa ctatgaagcg caagagaatg cgattctgcc aaaaaatgca gacgccaacg     6300

gtgcctataa catcgccagg aaagtcctgt gggcgatcgg ccagttcaaa aaggccgaag     6360

acgaaaaatt ggacaaggtc aaaatcgcta tcagcaacaa agagtggctg gagtatgctc     6420

agacatccgt aaagcattcc ggcggcagcc caaagaagaa gaggaaggtg agcggcggca     6480

gcccaaagaa gaagcgcaag gtctag                                          6506


<210>  14
<211>  4971
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LBCPF1-ABE2-X2

<400>  14
atgtcaaagc tcgagaaatt caccaactgt tattcgttga gcaaaacact gcggtttaaa       60

gcgattccag tcggcaagac tcaagagaat atagacaata agcggctgtt ggtggaagat      120

gaaaagcgcg cggaagacta caaaggggtg aagaagttgt tggacagata ctacctctct      180

tttatcaatg atgtcttgca ctcaatcaaa ttgaagaatc tgaacaacta catctccctc      240

ttcagaaaga aaacaaggac agaaaaggag aataaggaac ttgaaaattt ggagatcaat      300

ctgaggaaag agatcgcgaa agcctttaaa ggcaacgaag gatacaaaag tctgttcaag      360

aaggatataa ttgagacaat tttgccagag ttcctcgatg acaaggacga gattgcgctg      420

gtcaattcgt tcaacggatt cacaacagca ttcacaggct tctttgataa tcgggaaaat      480

atgttctctg aggaggcaaa gtccacttct attgcgttca ggtgtatcaa tgagaatctc      540

actaggtaca tttccaacat ggatatcttt gagaaggttg acgcaatttt tgacaagcac      600

gaagttcagg agattaagga gaagatcctc aattccgatt atgacgttga ggacttcttc      660

gaaggtgagt tttttaattt cgtgctcact caagagggta tcgacgtgta taatgcgatc      720

atcggtgggt tcgtgactga gtccggtgaa aagattaagg gattgaacga gtatatcaac      780

ctttacaacc aaaagacgaa acagaagctg ccaaagttca agcctcttta caaacaggtt      840

ctttcagacc gcgagtcact ctcgttctat ggggagggct acacttcgga tgaggaagtc      900

ctggaggtgt tcaggaatac tctcaataag aattcggaga ttttctcttc tataaaaaaa      960

ctggaaaagt tgtttaagaa ttttgacgaa tactctagcg ccggcatatt tgtgaaaaac     1020

ggcccggcca tatcaacgat aagtaaagat atcttcggcg aatggaacgt gatcagagac     1080

aaatggaacg cggagtatga cgatattcac ctgaagaaga aggctgtcgt aacggagaag     1140

tacgaggatg atcgcaggaa aagcttcaaa aagatcggaa gtttcagcct ggaacagttg     1200

caggagtatg ctgacgccga tcttagcgtc gtcgagaagt tgaaggagat aatcatccaa     1260

aaggtcgacg agatatataa agtctatgga tcaagtgaaa aactgttcga cgccgacttc     1320

gttttggaga agtccctgaa gaagaacgac gctgttgttg ccattatgaa ggatctgctc     1380

gacagcgtga agagtttcga gaactatatt aaggcttttt tcggggaggg gaaggagact     1440

aacagagatg agtccttcta cggagacttc gtcctcgcgt acgatatact ccttaaggta     1500

gaccacatct acgacgcaat cagaaattac gtgacacaaa agccgtacag caaggacaag     1560

ttcaaactct acttccagaa cccccagttc atgggcggct gggacaagga caaggaaacg     1620

gattacaggg ctacgatcct gaggtatggt tcaaaatact acttggcgat tatggacaag     1680

aagtacgcca agtgtctcca gaagattgac aaagacgatg tcaatggcaa ttatgagaag     1740

atcaactaca agctgcttcc gggtccgaac aagatgctcc caaaggtttt cttcagcaag     1800

aaatggatgg cctactataa cccaagcgag gacatccaga agatttataa gaacggtacg     1860

ttcaagaagg gcgacatgtt caatcttaac gactgtcaca agctgatcga cttcttcaaa     1920

gactcaatta gccggtaccc aaagtggtct aacgcctatg acttcaactt ttcggaaacc     1980

gagaagtaca aggatatagc cggattttat agagaggtgg aagagcaggg ctacaaggtg     2040

tcattcgagt ccgccagcaa gaaggaagtg gacaagctcg tggaagaggg taagctctac     2100

atgttccaga tttataataa agactttagc gataagagcc acgggacacc taatctccac     2160

acaatgtatt tcaagctgct cttcgacgag aataaccacg gccaaatcag gttgtcagga     2220

ggggctgaac tcttcatgcg gcgcgctagc cttaagaagg aggagcttgt agtccaccct     2280

gcgaatagtc caattgcgaa taagaacccg gacaatccta aaaagactac aacattgagc     2340

tacgacgtgt acaaggataa gaggttttcc gaggatcagt acgagctcca catcccgatt     2400

gcgatcaaca agtgcccaaa gaatattttc aagataaaca cagaggtgcg tgtactcctg     2460

aagcatgacg acaatcctta cgtcattggg attgctcggg gcgagaggaa cctcctctat     2520

attgtggtgg tggacgggaa ggggaacata gtcgaacagt actcccttaa cgaaataatt     2580

aacaatttca acggcatccg tatcaagacc gactaccatt cgttgctgga caagaaggag     2640

aaggagagat ttgaggcgcg gcaaaattgg acaagtatcg agaacatcaa ggaactcaaa     2700

gcaggttata tctctcaagt tgtgcataag atatgcgagc tggttgagaa gtatgacgca     2760

gtgatcgctc ttgaggacct caactcgggc tttaagaatt ctagagttaa agtggagaag     2820

caggtctatc aaaagttcga gaagatgctt atagataagc tcaactacat ggtcgataag     2880

aaatcgaacc catgtgccac cggcggcgca ctcaaaggtt accaaataac aaacaaattc     2940

gagtccttca aatcgatgag tactcagaat gggttcatat tttatatacc ggcgtggctt     3000

acgtctaaga tcgacccgtc aactggtttt gtcaacctgt tgaagacgaa atacacgtcc     3060

attgccgatt cgaaaaagtt catatctagt tttgatcgta ttatgtacgt cccagaggaa     3120

gatcttttcg agtttgctct cgactacaaa aacttttcgc ggaccgatgc ggattacatt     3180

aaaaaatgga aactctattc gtacggcaac agaatcagga tttttcgcaa ccctaagaag     3240

aataacgtct ttgattggga ggaagtttgc ttgactagcg cgtacaagga gctctttaat     3300

aagtatggca ttaactacca acagggtgat atcagagcac tgctttgcga acaatctgac     3360

aaggctttct actcatcctt catggctttg atgagcctga tgctccagat gagaaattca     3420

attacaggca gaaccgacgt ggatttcttg atctccccgg ttaaaaattc tgatggcatc     3480

ttttacgata gcaggaacta tgaagcgcaa gagaatgcga ttctgccaaa aaatgcagac     3540

gccaacggtg cctataacat cgccaggaaa gtcctgtggg cgatcggcca gttcaaaaag     3600

gccgaagacg aaaaattgga caaggtcaaa atcgctatca gcaacaaaga gtggctggag     3660

tatgctcaga catccgtaaa gcataagctt atgccaaaaa agaagagaaa ggtttcaggc     3720

ggctcctccg aggtggagtt ctctcacgag tattggatga ggcacgctct tacacttgct     3780

aagagagctt gggacgaaag agaagtgcca gttggcgccg ttcttgtgca taataatagg     3840

gtgatcggcg agggttggaa tagaccaatt ggaaggcatg atccaacagc tcacgcagag     3900

attatggctc tcagacaagg cggcctcgtt atgcagaact acaggctcat tgacgctaca     3960

ctctacgtga cactcgaacc ttgcgttatg tgcgccggag ctatgattca ttctaggatt     4020

ggcagggtcg tgtttggagc tagggacgct aaaacaggag ccgccggatc tcttatggac     4080

gtgttgcatc atccaggcat gaaccatagg gtggagatta cagagggcat tcttgcagac     4140

gagtgcgctg ctcttctttc cgatttcttc aggatgagaa ggcaggagat taaggcccag     4200

aagaaggctc agtcttctac agatagcgga ggatcttccg gaggatctag cggctccgag     4260

acaccaggaa catccgaaag cgctacacca gaatctagcg gaggctcttc cggaggatct     4320

tctgaagtgg agttctccca cgagtattgg atgaggcacg ctcttacact tgctaaaagg     4380

gctagggacg aaagggaagt tccagttgga gctgttctcg tgctcaataa cagggtgatt     4440

ggcgagggtt ggaatagagc cattggactc catgatccaa cagctcacgc agagattatg     4500

gctcttagac aaggcggcct cgttatgcag aattacagac tcatcgacgc cacactctac     4560

gttaccttcg aaccttgcgt tatgtgcgcc ggagctatga tccattctag gattggcagg     4620

gtcgtgttcg gcgttagaaa cgctaagaca ggagctgcag gctctcttat ggacgttctt     4680

cattacccag gcatgaatca tagagtggag atcacagaag gcattcttgc agacgagtgc     4740

gcagctctcc tttgctattt cttcaggatg ccgaggcaag ttttcaacgc tcagaagaag     4800

gcccagtctt ctacagattc cggcggatct tctggaggat ctagcggctc cgagacacca     4860

ggaacatccg aatccgctac accagagtct tctggaggat ctagcggagg atctcttaag     4920

aagagaccag cagctacaaa gaaggccgga caagctaaga agaagaagta g              4971


<210>  15
<211>  4992
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LBCPF1-ABE2-X3

<400>  15
atgccaaaaa agaagagaaa ggtttcaaag ctcgagaaat tcaccaactg ttattcgttg       60

agcaaaacac tgcggtttaa agcgattcca gtcggcaaga ctcaagagaa tatagacaat      120

aagcggctgt tggtggaaga tgaaaagcgc gcggaagact acaaaggggt gaagaagttg      180

ttggacagat actacctctc ttttatcaat gatgtcttgc actcaatcaa attgaagaat      240

ctgaacaact acatctccct cttcagaaag aaaacaagga cagaaaagga gaataaggaa      300

cttgaaaatt tggagatcaa tctgaggaaa gagatcgcga aagcctttaa aggcaacgaa      360

ggatacaaaa gtctgttcaa gaaggatata attgagacaa ttttgccaga gttcctcgat      420

gacaaggacg agattgcgct ggtcaattcg ttcaacggat tcacaacagc attcacaggc      480

ttctttgata atcgggaaaa tatgttctct gaggaggcaa agtccacttc tattgcgttc      540

aggtgtatca atgagaatct cactaggtac atttccaaca tggatatctt tgagaaggtt      600

gacgcaattt ttgacaagca cgaagttcag gagattaagg agaagatcct caattccgat      660

tatgacgttg aggacttctt cgaaggtgag ttttttaatt tcgtgctcac tcaagagggt      720

atcgacgtgt ataatgcgat catcggtggg ttcgtgactg agtccggtga aaagattaag      780

ggattgaacg agtatatcaa cctttacaac caaaagacga aacagaagct gccaaagttc      840

aagcctcttt acaaacaggt tctttcagac cgcgagtcac tctcgttcta tggggagggc      900

tacacttcgg atgaggaagt cctggaggtg ttcaggaata ctctcaataa gaattcggag      960

attttctctt ctataaaaaa actggaaaag ttgtttaaga attttgacga atactctagc     1020

gccggcatat ttgtgaaaaa cggcccggcc atatcaacga taagtaaaga tatcttcggc     1080

gaatggaacg tgatcagaga caaatggaac gcggagtatg acgatattca cctgaagaag     1140

aaggctgtcg taacggagaa gtacgaggat gatcgcagga aaagcttcaa aaagatcgga     1200

agtttcagcc tggaacagtt gcaggagtat gctgacgccg atcttagcgt cgtcgagaag     1260

ttgaaggaga taatcatcca aaaggtcgac gagatatata aagtctatgg atcaagtgaa     1320

aaactgttcg acgccgactt cgttttggag aagtccctga agaagaacga cgctgttgtt     1380

gccattatga aggatctgct cgacagcgtg aagagtttcg agaactatat taaggctttt     1440

ttcggggagg ggaaggagac taacagagat gagtccttct acggagactt cgtcctcgcg     1500

tacgatatac tccttaaggt agaccacatc tacgacgcaa tcagaaatta cgtgacacaa     1560

aagccgtaca gcaaggacaa gttcaaactc tacttccaga acccccagtt catgggcggc     1620

tgggacaagg acaaggaaac ggattacagg gctacgatcc tgaggtatgg ttcaaaatac     1680

tacttggcga ttatggacaa gaagtacgcc aagtgtctcc agaagattga caaagacgat     1740

gtcaatggca attatgagaa gatcaactac aagctgcttc cgggtccgaa caagatgctc     1800

ccaaaggttt tcttcagcaa gaaatggatg gcctactata acccaagcga ggacatccag     1860

aagatttata agaacggtac gttcaagaag ggcgacatgt tcaatcttaa cgactgtcac     1920

aagctgatcg acttcttcaa agactcaatt agccggtacc caaagtggtc taacgcctat     1980

gacttcaact tttcggaaac cgagaagtac aaggatatag ccggatttta tagagaggtg     2040

gaagagcagg gctacaaggt gtcattcgag tccgccagca agaaggaagt ggacaagctc     2100

gtggaagagg gtaagctcta catgttccag atttataata aagactttag cgataagagc     2160

cacgggacac ctaatctcca cacaatgtat ttcaagctgc tcttcgacga gaataaccac     2220

ggccaaatca ggttgtcagg aggggctgaa ctcttcatgc ggcgcgctag ccttaagaag     2280

gaggagcttg tagtccaccc tgcgaatagt ccaattgcga ataagaaccc ggacaatcct     2340

aaaaagacta caacattgag ctacgacgtg tacaaggata agaggttttc cgaggatcag     2400

tacgagctcc acatcccgat tgcgatcaac aagtgcccaa agaatatttt caagataaac     2460

acagaggtgc gtgtactcct gaagcatgac gacaatcctt acgtcattgg gattgctcgg     2520

ggcgagagga acctcctcta tattgtggtg gtggacggga aggggaacat agtcgaacag     2580

tactccctta acgaaataat taacaatttc aacggcatcc gtatcaagac cgactaccat     2640

tcgttgctgg acaagaagga gaaggagaga tttgaggcgc ggcaaaattg gacaagtatc     2700

gagaacatca aggaactcaa agcaggttat atctctcaag ttgtgcataa gatatgcgag     2760

ctggttgaga agtatgacgc agtgatcgct cttgaggacc tcaactcggg ctttaagaat     2820

tctagagtta aagtggagaa gcaggtctat caaaagttcg agaagatgct tatagataag     2880

ctcaactaca tggtcgataa gaaatcgaac ccatgtgcca ccggcggcgc actcaaaggt     2940

taccaaataa caaacaaatt cgagtccttc aaatcgatga gtactcagaa tgggttcata     3000

ttttatatac cggcgtggct tacgtctaag atcgacccgt caactggttt tgtcaacctg     3060

ttgaagacga aatacacgtc cattgccgat tcgaaaaagt tcatatctag ttttgatcgt     3120

attatgtacg tcccagagga agatcttttc gagtttgctc tcgactacaa aaacttttcg     3180

cggaccgatg cggattacat taaaaaatgg aaactctatt cgtacggcaa cagaatcagg     3240

atttttcgca accctaagaa gaataacgtc tttgattggg aggaagtttg cttgactagc     3300

gcgtacaagg agctctttaa taagtatggc attaactacc aacagggtga tatcagagca     3360

ctgctttgcg aacaatctga caaggctttc tactcatcct tcatggcttt gatgagcctg     3420

atgctccaga tgagaaattc aattacaggc agaaccgacg tggatttctt gatctccccg     3480

gttaaaaatt ctgatggcat cttttacgat agcaggaact atgaagcgca agagaatgcg     3540

attctgccaa aaaatgcaga cgccaacggt gcctataaca tcgccaggaa agtcctgtgg     3600

gcgatcggcc agttcaaaaa ggccgaagac gaaaaattgg acaaggtcaa aatcgctatc     3660

agcaacaaag agtggctgga gtatgctcag acatccgtaa agcataagct tatgccaaaa     3720

aagaagagaa aggtttcagg cggctcctcc gaggtggagt tctctcacga gtattggatg     3780

aggcacgctc ttacacttgc taagagagct tgggacgaaa gagaagtgcc agttggcgcc     3840

gttcttgtgc ataataatag ggtgatcggc gagggttgga atagaccaat tggaaggcat     3900

gatccaacag ctcacgcaga gattatggct ctcagacaag gcggcctcgt tatgcagaac     3960

tacaggctca ttgacgctac actctacgtg acactcgaac cttgcgttat gtgcgccgga     4020

gctatgattc attctaggat tggcagggtc gtgtttggag ctagggacgc taaaacagga     4080

gccgccggat ctcttatgga cgtgttgcat catccaggca tgaaccatag ggtggagatt     4140

acagagggca ttcttgcaga cgagtgcgct gctcttcttt ccgatttctt caggatgaga     4200

aggcaggaga ttaaggccca gaagaaggct cagtcttcta cagatagcgg aggatcttcc     4260

ggaggatcta gcggctccga gacaccagga acatccgaaa gcgctacacc agaatctagc     4320

ggaggctctt ccggaggatc ttctgaagtg gagttctccc acgagtattg gatgaggcac     4380

gctcttacac ttgctaaaag ggctagggac gaaagggaag ttccagttgg agctgttctc     4440

gtgctcaata acagggtgat tggcgagggt tggaatagag ccattggact ccatgatcca     4500

acagctcacg cagagattat ggctcttaga caaggcggcc tcgttatgca gaattacaga     4560

ctcatcgacg ccacactcta cgttaccttc gaaccttgcg ttatgtgcgc cggagctatg     4620

atccattcta ggattggcag ggtcgtgttc ggcgttagaa acgctaagac aggagctgca     4680

ggctctctta tggacgttct tcattaccca ggcatgaatc atagagtgga gatcacagaa     4740

ggcattcttg cagacgagtg cgcagctctc ctttgctatt tcttcaggat gccgaggcaa     4800

gttttcaacg ctcagaagaa ggcccagtct tctacagatt ccggcggatc ttctggagga     4860

tctagcggct ccgagacacc aggaacatcc gaatccgcta caccagagtc ttctggagga     4920

tctagcggag gatctcttaa gaagagacca gcagctacaa agaaggccgg acaagctaag     4980

aagaagaagt ag                                                         4992


<210>  16
<211>  5686
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PJIT163-GFP

<400>  16
gagctcggta cctgacccgg tcgtgcccct ctctagagat aatgagcatt gcatgtctaa       60

gttataaaaa attaccacat attttttttg tcacacttgt ttgaagtgca gtttatctat      120

ctttatacat atatttaaac tttactctac gaataatata atctatagta ctacaataat      180

atcagtgttt tagagaatca tataaatgaa cagttagaca tggtctaaag gacaattgag      240

tattttgaca acaggactct acagttttat ctttttagtg tgcatgtgtt ctcctttttt      300

tttgcaaata gcttcaccta tataatactt catccatttt attagtacat ccatttaggg      360

tttagggtta atggttttta tagactaatt tttttagtac atctatttta ttctatttta      420

gcctctaaat taagaaaact aaaactctat tttagttttt ttatttaata atttagatat      480

aaaatagaat aaaataaagt gactaaaaat taaacaaata ccctttaaga aattaaaaaa      540

actaaggaaa catttttctt gtttcgagta gataatgcca gcctgttaaa cgccgtcgac      600

gagtctaacg gacaccaacc agcgaaccag cagcgtcgcg tcgggccaag cgaagcagac      660

ggcacggcat ctctgtcgct gcctctggac ccctctcgat cgagagttcc gctccaccgt      720

tggacttgct ccgctgtcgg catccagaaa ttgcgtggcg gagcggcaga cgtgagccgg      780

cacggcaggc ggcctcctcc tcctctcacg gcaccggcag ctacggggga ttcctttccc      840

accgctcctt cgctttccct tcctcgcccg ccgtaataaa tagacacccc ctccacaccc      900

tctttcccca acctcgtgtt gttcggagcg cacacacaca caaccagatc tcccccaaat      960

ccacccgtcg gcacctccgc ttcaaggtac gccgctcgtc ctcccccccc ccccctctct     1020

accttctcta gatcggcgtt ccggtccatg gttagggccc ggtagttcta cttctgttca     1080

tgtttgtgtt agatccgtgt ttgtgttaga tccgtgctgc tagcgttcgt acacggatgc     1140

gacctgtacg tcagacacgt tctgattgct aacttgccag tgtttctctt tggggaatcc     1200

tgggatggct ctagccgttc cgcagacggg atcgatttca tgattttttt tgtttcgttg     1260

catagggttt ggtttgccct tttcctttat ttcaatatat gccgtgcact tgtttgtcgg     1320

gtcatctttt catgcttttt tttgtcttgg ttgtgatgat gtggtctggt tgggcggtcg     1380

ttctagatcg gagtagaatt aattctgttt caaactacct ggtggattta ttaattttgg     1440

atctgtatgt gtgtgccata catattcata gttacgaatt gaagatgatg gatggaaata     1500

tcgatctagg ataggtatac atgttgatgc gggttttact gatgcatata cagagatgct     1560

ttttgttcgc ttggttgtga tgatgtggtg tggttgggcg gtcgttcatt cgttctagat     1620

cggagtagaa tactgtttca aactacctgg tgtatttatt aattttggaa ctgtatgtgt     1680

gtgtcataca tcttcatagt tacgagttta agatggatgg aaatatcgat ctaggatagg     1740

tatacatgtt gatgtgggtt ttactgatgc atatacatga tggcatatgc agcatctatt     1800

catatgctct aaccttgagt acctatctat tataataaac aagtatgttt tataattatt     1860

ttgatcttga tatacttgga tgatggcata tgcagcagct atatgtggat ttttttagcc     1920

ctgccttcat acgctattta tttgcttggt actgtttctt ttgtcgatgc tcaccctgtt     1980

gtttggtgtt acttctgcaa agcttgtcga cggatccatg gtgagcaagg gcgaggagct     2040

gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt     2100

cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat     2160

ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccacct tcacctacgg     2220

cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc     2280

catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa     2340

gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg     2400

catcgacttc aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag     2460

ccacaacgtc tatatcatgg ccgacaagca gaagaacggc atcaaggtga acttcaagat     2520

ccgccacaac atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc     2580

catcggcgac ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccgccct     2640

gagcaaagac cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc     2700

cgggatcact cacggcatgg acgagctgta caagtaaccc gggaattcgg tacgctgaaa     2760

tcaccagtct ctctctacaa atctatctct ctctattttc tccataaata atgtgtgagt     2820

agtttcccga taagggaaat tagggttctt atagggtttc gctcatgtgt tgagcatata     2880

agaaaccctt agtatgtatt tgtatttgta aaatacttct atcaataaaa tttctaattc     2940

ctaaaaccaa aatccagtac taaaatccag atctcctaaa gtccctatag atctttgtcg     3000

tgaatataaa ccagacacga gacgactaaa cctggagccc agacgccgtt cgaagctaga     3060

agtaccgctt aggcaggagg ccgttaggga aaagatgcta aggcagggtt ggttacgttg     3120

actcccccgt aggtttggtt taaatatgat gaagtggacg gaaggaagga ggaagacaag     3180

gaaggataag gttgcaggcc ctgtgcaagg taagaagatg gaaatttgat agaggtacgc     3240

tactatactt atactatacg ctaagggaat gcttgtattt ataccctata ccccctaata     3300

accccttatc aatttaagaa ataatccgca taagcccccg cttaaaaatt ggtatcagag     3360

ccatgaatag gtctatgacc aaaactcaag aggataaaac ctcaccaaaa tacgaaagag     3420

ttcttaactc taaagataaa agatctttca agatcaaaac tagttccctc acaccggagc     3480

atgcgatatc ctcgagagat ctaggcgtaa tcatggtcat agctgtttcc tgtgtgaaat     3540

tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg     3600

ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag     3660

tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt     3720

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg     3780

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg     3840

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag     3900

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga     3960

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct     4020

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc     4080

tttctccctt cgggaagcgt ggcgctttct caatgctcac gctgtaggta tctcagttcg     4140

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc     4200

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca     4260

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag     4320

ttcttgaagt ggtggcctaa ctacggctac actagaagga cagtatttgg tatctgcgct     4380

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc     4440

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga     4500

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca     4560

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat     4620

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     4680

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt     4740

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt     4800

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag     4860

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct     4920

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt     4980

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc     5040

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt     5100

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg     5160

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg     5220

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct     5280

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc     5340

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt     5400

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt     5460

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg     5520

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat     5580

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg     5640

cgcacatttc cccgaaaagt gccacctgcc agtgccaagc taattc                    5686


<210>  17
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pBUI-mGFP

<400>  17
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccttcaccta cggcgtgtag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actcacggca tggacgagct gtacaagtaa      720

                      
<210>  18
<211>  1307
<212>  PRT
<213>  Acidaminococcus sp.

<400>  18

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  19
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  19

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  20
<211>  1228
<212>  PRT
<213>  Lachnospiraceae bacterium

<400>  20

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  21
<211>  1329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ASCPF1-2NLS

<400>  21

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn Ser 
    1295                 1300                 1305             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val Ser Gly  Gly Ser Pro 
    1310                 1315                 1320             


Lys Lys  Lys Arg Lys Val 
    1325                 


<210>  22
<211>  1322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FNCPF1-2NLS

<400>  22

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  Ser Gly Gly Ser Pro  Lys Lys Lys 
    1295                 1300                 1305             


Arg Lys  Val Ser Gly Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1310                 1315                 1320         


<210>  23
<211>  1252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LBCPF1-2NLS

<400>  23

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Glu Thr Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
                165                 170                 175     


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
            180                 185                 190         


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
        195                 200                 205             


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
    210                 215                 220                 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
225                 230                 235                 240 


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
                245                 250                 255     


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
            260                 265                 270         


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
        275                 280                 285             


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
    290                 295                 300                 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
305                 310                 315                 320 


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
                325                 330                 335     


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
            340                 345                 350         


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
        355                 360                 365             


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
    370                 375                 380                 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
385                 390                 395                 400 


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
                405                 410                 415     


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
            420                 425                 430         


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
        435                 440                 445             


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
    450                 455                 460                 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
465                 470                 475                 480 


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
                485                 490                 495     


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
            500                 505                 510         


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
        515                 520                 525             


Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr 
    530                 535                 540                 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
545                 550                 555                 560 


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
                565                 570                 575     


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
            580                 585                 590         


Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
        595                 600                 605             


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
    610                 615                 620                 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
625                 630                 635                 640 


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
                645                 650                 655     


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
            660                 665                 670         


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
        675                 680                 685             


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
    690                 695                 700                 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
705                 710                 715                 720 


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
                725                 730                 735     


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
            740                 745                 750         


Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala 
        755                 760                 765             


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
    770                 775                 780                 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
785                 790                 795                 800 


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
                805                 810                 815     


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
            820                 825                 830         


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
        835                 840                 845             


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
    850                 855                 860                 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
865                 870                 875                 880 


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
                885                 890                 895     


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
            900                 905                 910         


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
        915                 920                 925             


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
    930                 935                 940                 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
945                 950                 955                 960 


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
                965                 970                 975     


Gln Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn 
            980                 985                 990         


Gly Phe Ile Phe Tyr Ile Pro Ala  Trp Leu Thr Ser Lys  Ile Asp Pro 
        995                 1000                 1005             


Ser Thr  Gly Phe Val Asn Leu  Leu Lys Thr Lys Tyr  Thr Ser Ile 
    1010                 1015                 1020             


Ala Asp  Ser Lys Lys Phe Ile  Ser Ser Phe Asp Arg  Ile Met Tyr 
    1025                 1030                 1035             


Val Pro  Glu Glu Asp Leu Phe  Glu Phe Ala Leu Asp  Tyr Lys Asn 
    1040                 1045                 1050             


Phe Ser  Arg Thr Asp Ala Asp  Tyr Ile Lys Lys Trp  Lys Leu Tyr 
    1055                 1060                 1065             


Ser Tyr  Gly Asn Arg Ile Arg  Ile Phe Arg Asn Pro  Lys Lys Asn 
    1070                 1075                 1080             


Asn Val  Phe Asp Trp Glu Glu  Val Cys Leu Thr Ser  Ala Tyr Lys 
    1085                 1090                 1095             


Glu Leu  Phe Asn Lys Tyr Gly  Ile Asn Tyr Gln Gln  Gly Asp Ile 
    1100                 1105                 1110             


Arg Ala  Leu Leu Cys Glu Gln  Ser Asp Lys Ala Phe  Tyr Ser Ser 
    1115                 1120                 1125             


Phe Met  Ala Leu Met Ser Leu  Met Leu Gln Met Arg  Asn Ser Ile 
    1130                 1135                 1140             


Thr Gly  Arg Thr Asp Val Asp  Phe Leu Ile Ser Pro  Val Lys Asn 
    1145                 1150                 1155             


Ser Asp  Gly Ile Phe Tyr Asp  Ser Arg Asn Tyr Glu  Ala Gln Glu 
    1160                 1165                 1170             


Asn Ala  Ile Leu Pro Lys Asn  Ala Asp Ala Asn Gly  Ala Tyr Asn 
    1175                 1180                 1185             


Ile Ala  Arg Lys Val Leu Trp  Ala Ile Gly Gln Phe  Lys Lys Ala 
    1190                 1195                 1200             


Glu Asp  Glu Lys Leu Asp Lys  Val Lys Ile Ala Ile  Ser Asn Lys 
    1205                 1210                 1215             


Glu Trp  Leu Glu Tyr Ala Gln  Thr Ser Val Lys His  Ser Gly Gly 
    1220                 1225                 1230             


Ser Pro  Lys Lys Lys Arg Lys  Val Ser Gly Gly Ser  Pro Lys Lys 
    1235                 1240                 1245             


Lys Arg  Lys Val 
    1250         


<210>  24
<211>  1664
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dFNCPF1-PBE-2NLS

<400>  24

Met Pro Lys Lys Lys Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala 
1               5                   10                  15      


Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val 
            20                  25                  30          


Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu 
        35                  40                  45              


Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln Asn 
    50                  55                  60                  


Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu 
65                  70                  75                  80  


Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser 
                85                  90                  95      


Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser 
            100                 105                 110         


Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His 
        115                 120                 125             


His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser 
    130                 135                 140                 


Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp 
145                 150                 155                 160 


Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg 
                165                 170                 175     


Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile 
            180                 185                 190         


Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro 
        195                 200                 205             


Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg 
    210                 215                 220                 


Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Leu Lys Ser Ile Tyr 
                245                 250                 255     


Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Glu 
            260                 265                 270         


Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys Ala Arg Gly Leu 
        275                 280                 285             


Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys Lys Ala Lys Gln 
    290                 295                 300                 


Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu Ile Leu Ser Ser 
305                 310                 315                 320 


Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser Asp Val Tyr Phe 
                325                 330                 335     


Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys Asp Phe Lys Ser 
            340                 345                 350         


Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr Ile Lys Asp Ser 
        355                 360                 365             


Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile Asp Ala Lys Lys 
    370                 375                 380                 


Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln Ser Lys Asp Asn 
385                 390                 395                 400 


Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr Asp Ile Asp Glu 
                405                 410                 415     


Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr Thr Tyr Phe Lys 
            420                 425                 430         


Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser Asn Asp Ile Pro 
        435                 440                 445             


Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu Pro Lys Phe Leu 
    450                 455                 460                 


Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys Ala Pro Glu Ala 
465                 470                 475                 480 


Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu Glu Leu Thr Phe 
                485                 490                 495     


Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg Val Phe Ser Leu 
            500                 505                 510         


Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr Leu Asn Gln Ser 
        515                 520                 525             


Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys Phe Val Asn Gly 
    530                 535                 540                 


Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile Asn Leu Tyr Ser 
545                 550                 555                 560 


Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys Met Ser Val Leu 
                565                 570                 575     


Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser Phe Val Ile Asp 
            580                 585                 590         


Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met Gln Ser Phe Tyr 
        595                 600                 605             


Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys Ser Ile Lys Glu 
    610                 615                 620                 


Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln Lys Leu Asp Leu 
625                 630                 635                 640 


Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr Asp Leu Ser Gln 
                645                 650                 655     


Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala Val Leu Glu Tyr 
            660                 665                 670         


Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn Pro Ser Lys Lys 
        675                 680                 685             


Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala Lys Tyr Leu Ser 
    690                 695                 700                 


Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn Lys His Arg Asp 
705                 710                 715                 720 


Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala Asn Phe Ala Ala 
                725                 730                 735     


Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys Asp Asn Leu Ala 
            740                 745                 750         


Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys Asp Leu Leu Gln 
        755                 760                 765             


Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp Leu Leu Asp Gln 
    770                 775                 780                 


Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His Ile Ser Gln Ser 
785                 790                 795                 800 


Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His Phe Tyr Leu Val 
                805                 810                 815     


Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val Pro Leu Tyr Asn 
            820                 825                 830         


Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser Asp Glu Lys Phe 
        835                 840                 845             


Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly Trp Asp Lys Asn 
    850                 855                 860                 


Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys Asp Asp Lys Tyr 
865                 870                 875                 880 


Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile Phe Asp Asp Lys 
                885                 890                 895     


Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys Ile Val Tyr Lys 
            900                 905                 910         


Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val Phe Phe Ser Ala 
        915                 920                 925             


Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile Leu Arg Ile Arg 
    930                 935                 940                 


Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln Lys Gly Tyr Glu 
945                 950                 955                 960 


Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe Ile Asp Phe Tyr 
                965                 970                 975     


Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp Phe Gly Phe Arg 
            980                 985                 990         


Phe Ser Asp Thr Gln Arg Tyr Asn  Ser Ile Asp Glu Phe  Tyr Arg Glu 
        995                 1000                 1005             


Val Glu  Asn Gln Gly Tyr Lys  Leu Thr Phe Glu Asn  Ile Ser Glu 
    1010                 1015                 1020             


Ser Tyr  Ile Asp Ser Val Val  Asn Gln Gly Lys Leu  Tyr Leu Phe 
    1025                 1030                 1035             


Gln Ile  Tyr Asn Lys Asp Phe  Ser Ala Tyr Ser Lys  Gly Arg Pro 
    1040                 1045                 1050             


Asn Leu  His Thr Leu Tyr Trp  Lys Ala Leu Phe Asp  Glu Arg Asn 
    1055                 1060                 1065             


Leu Gln  Asp Val Val Tyr Lys  Leu Asn Gly Glu Ala  Glu Leu Phe 
    1070                 1075                 1080             


Tyr Arg  Lys Gln Ser Ile Pro  Lys Lys Ile Thr His  Pro Ala Lys 
    1085                 1090                 1095             


Glu Ala  Ile Ala Asn Lys Asn  Lys Asp Asn Pro Lys  Lys Glu Ser 
    1100                 1105                 1110             


Val Phe  Glu Tyr Asp Leu Ile  Lys Asp Lys Arg Phe  Thr Glu Asp 
    1115                 1120                 1125             


Lys Phe  Phe Phe His Cys Pro  Ile Thr Ile Asn Phe  Lys Ser Ser 
    1130                 1135                 1140             


Gly Ala  Asn Lys Phe Asn Asp  Glu Ile Asn Leu Leu  Leu Lys Glu 
    1145                 1150                 1155             


Lys Ala  Asn Asp Val His Ile  Leu Ser Ile Ala Arg  Gly Glu Arg 
    1160                 1165                 1170             


His Leu  Ala Tyr Tyr Thr Leu  Val Asp Gly Lys Gly  Asn Ile Ile 
    1175                 1180                 1185             


Lys Gln  Asp Thr Phe Asn Ile  Ile Gly Asn Asp Arg  Met Lys Thr 
    1190                 1195                 1200             


Asn Tyr  His Asp Lys Leu Ala  Ala Ile Glu Lys Asp  Arg Asp Ser 
    1205                 1210                 1215             


Ala Arg  Lys Asp Trp Lys Lys  Ile Asn Asn Ile Lys  Glu Met Lys 
    1220                 1225                 1230             


Glu Gly  Tyr Leu Ser Gln Val  Val His Glu Ile Ala  Lys Leu Val 
    1235                 1240                 1245             


Ile Glu  Tyr Asn Ala Ile Val  Val Phe Glu Asp Leu  Asn Phe Gly 
    1250                 1255                 1260             


Phe Lys  Arg Gly Arg Phe Lys  Val Glu Lys Gln Val  Tyr Gln Lys 
    1265                 1270                 1275             


Leu Glu  Lys Met Leu Ile Glu  Lys Leu Asn Tyr Leu  Val Phe Lys 
    1280                 1285                 1290             


Asp Asn  Glu Phe Asp Lys Thr  Gly Gly Val Leu Arg  Ala Tyr Gln 
    1295                 1300                 1305             


Leu Thr  Ala Pro Phe Glu Thr  Phe Lys Lys Met Gly  Lys Gln Thr 
    1310                 1315                 1320             


Gly Ile  Ile Tyr Tyr Val Pro  Ala Gly Phe Thr Ser  Lys Ile Cys 
    1325                 1330                 1335             


Pro Val  Thr Gly Phe Val Asn  Gln Leu Tyr Pro Lys  Tyr Glu Ser 
    1340                 1345                 1350             


Val Ser  Lys Ser Gln Glu Phe  Phe Ser Lys Phe Asp  Lys Ile Cys 
    1355                 1360                 1365             


Tyr Asn  Leu Asp Lys Gly Tyr  Phe Glu Phe Ser Phe  Asp Tyr Lys 
    1370                 1375                 1380             


Asn Phe  Gly Asp Lys Ala Ala  Lys Gly Lys Trp Thr  Ile Ala Ser 
    1385                 1390                 1395             


Phe Gly  Ser Arg Leu Ile Asn  Phe Arg Asn Ser Asp  Lys Asn His 
    1400                 1405                 1410             


Asn Trp  Asp Thr Arg Glu Val  Tyr Pro Thr Lys Glu  Leu Glu Lys 
    1415                 1420                 1425             


Leu Leu  Lys Asp Tyr Ser Ile  Glu Tyr Gly His Gly  Glu Cys Ile 
    1430                 1435                 1440             


Lys Ala  Ala Ile Cys Gly Glu  Ser Asp Lys Lys Phe  Phe Ala Lys 
    1445                 1450                 1455             


Leu Thr  Ser Val Leu Asn Thr  Ile Leu Gln Met Arg  Asn Ser Lys 
    1460                 1465                 1470             


Thr Gly  Thr Glu Leu Asp Tyr  Leu Ile Ser Pro Val  Ala Asp Val 
    1475                 1480                 1485             


Asn Gly  Asn Phe Phe Asp Ser  Arg Gln Ala Pro Lys  Asn Met Pro 
    1490                 1495                 1500             


Gln Asp  Ala Asp Ala Asn Gly  Ala Tyr His Ile Gly  Leu Lys Gly 
    1505                 1510                 1515             


Leu Met  Leu Leu Gly Arg Ile  Lys Asn Asn Gln Glu  Gly Lys Lys 
    1520                 1525                 1530             


Leu Asn  Leu Val Ile Lys Asn  Glu Glu Tyr Phe Glu  Phe Val Gln 
    1535                 1540                 1545             


Asn Arg  Asn Asn Thr Arg Asp  Ser Gly Gly Ser Thr  Asn Leu Ser 
    1550                 1555                 1560             


Asp Ile  Ile Glu Lys Glu Thr  Gly Lys Gln Leu Val  Ile Gln Glu 
    1565                 1570                 1575             


Ser Ile  Leu Met Leu Pro Glu  Glu Val Glu Glu Val  Ile Gly Asn 
    1580                 1585                 1590             


Lys Pro  Glu Ser Asp Ile Leu  Val His Thr Ala Tyr  Asp Glu Ser 
    1595                 1600                 1605             


Thr Asp  Glu Asn Val Met Leu  Leu Thr Ser Asp Ala  Pro Glu Tyr 
    1610                 1615                 1620             


Lys Pro  Trp Ala Leu Val Ile  Gln Asp Ser Asn Gly  Glu Asn Lys 
    1625                 1630                 1635             


Ile Lys  Met Leu Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1640                 1645                 1650             


Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys Val 
    1655                 1660                 


<210>  25
<211>  1592
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dLBCPF1-PBE-2NLS

<400>  25

Met Pro Lys Lys Lys Arg Lys Val Ser Ser Glu Thr Gly Pro Val Ala 
1               5                   10                  15      


Val Asp Pro Thr Leu Arg Arg Arg Ile Glu Pro His Glu Phe Glu Val 
            20                  25                  30          


Phe Phe Asp Pro Arg Glu Leu Arg Lys Glu Thr Cys Leu Leu Tyr Glu 
        35                  40                  45              


Ile Asn Trp Gly Gly Arg His Ser Ile Trp Arg His Thr Ser Gln Asn 
    50                  55                  60                  


Thr Asn Lys His Val Glu Val Asn Phe Ile Glu Lys Phe Thr Thr Glu 
65                  70                  75                  80  


Arg Tyr Phe Cys Pro Asn Thr Arg Cys Ser Ile Thr Trp Phe Leu Ser 
                85                  90                  95      


Trp Ser Pro Cys Gly Glu Cys Ser Arg Ala Ile Thr Glu Phe Leu Ser 
            100                 105                 110         


Arg Tyr Pro His Val Thr Leu Phe Ile Tyr Ile Ala Arg Leu Tyr His 
        115                 120                 125             


His Ala Asp Pro Arg Asn Arg Gln Gly Leu Arg Asp Leu Ile Ser Ser 
    130                 135                 140                 


Gly Val Thr Ile Gln Ile Met Thr Glu Gln Glu Ser Gly Tyr Cys Trp 
145                 150                 155                 160 


Arg Asn Phe Val Asn Tyr Ser Pro Ser Asn Glu Ala His Trp Pro Arg 
                165                 170                 175     


Tyr Pro His Leu Trp Val Arg Leu Tyr Val Leu Glu Leu Tyr Cys Ile 
            180                 185                 190         


Ile Leu Gly Leu Pro Pro Cys Leu Asn Ile Leu Arg Arg Lys Gln Pro 
        195                 200                 205             


Gln Leu Thr Phe Phe Thr Ile Ala Leu Gln Ser Cys His Tyr Gln Arg 
    210                 215                 220                 


Leu Pro Pro His Ile Leu Trp Ala Thr Gly Leu Lys Ser Gly Ser Glu 
225                 230                 235                 240 


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Leu Lys Ser Lys Leu 
                245                 250                 255     


Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys 
            260                 265                 270         


Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu 
        275                 280                 285             


Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys 
    290                 295                 300                 


Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser 
305                 310                 315                 320 


Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys 
                325                 330                 335     


Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn 
            340                 345                 350         


Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys 
        355                 360                 365             


Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu 
    370                 375                 380                 


Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr 
385                 390                 395                 400 


Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu 
                405                 410                 415     


Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu 
            420                 425                 430         


Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile 
        435                 440                 445             


Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser 
    450                 455                 460                 


Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val 
465                 470                 475                 480 


Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe 
                485                 490                 495     


Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn 
            500                 505                 510         


Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu 
        515                 520                 525             


Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu 
    530                 535                 540                 


Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr Leu 
545                 550                 555                 560 


Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu 
                565                 570                 575     


Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn 
            580                 585                 590         


Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn 
        595                 600                 605             


Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu Lys 
    610                 615                 620                 


Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser 
625                 630                 635                 640 


Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala 
                645                 650                 655     


Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile Gln 
            660                 665                 670         


Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe 
        675                 680                 685             


Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala Val 
    690                 695                 700                 


Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu Asn 
705                 710                 715                 720 


Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu 
                725                 730                 735     


Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys Val 
            740                 745                 750         


Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr 
        755                 760                 765             


Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly 
    770                 775                 780                 


Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg 
785                 790                 795                 800 


Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys 
                805                 810                 815     


Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys 
            820                 825                 830         


Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val 
        835                 840                 845             


Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile 
    850                 855                 860                 


Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp Met Phe Asn 
865                 870                 875                 880 


Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser 
                885                 890                 895     


Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr 
            900                 905                 910         


Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln 
        915                 920                 925             


Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu Val Asp Lys 
    930                 935                 940                 


Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp 
945                 950                 955                 960 


Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr Met Tyr Phe 
                965                 970                 975     


Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg Leu Ser Gly 
            980                 985                 990         


Gly Ala Glu Leu Phe Met Arg Arg  Ala Ser Leu Lys Lys  Glu Glu Leu 
        995                 1000                 1005             


Val Val  His Pro Ala Asn Ser  Pro Ile Ala Asn Lys  Asn Pro Asp 
    1010                 1015                 1020             


Asn Pro  Lys Lys Thr Thr Thr  Leu Ser Tyr Asp Val  Tyr Lys Asp 
    1025                 1030                 1035             


Lys Arg  Phe Ser Glu Asp Gln  Tyr Glu Leu His Ile  Pro Ile Ala 
    1040                 1045                 1050             


Ile Asn  Lys Cys Pro Lys Asn  Ile Phe Lys Ile Asn  Thr Glu Val 
    1055                 1060                 1065             


Arg Val  Leu Leu Lys His Asp  Asp Asn Pro Tyr Val  Ile Gly Ile 
    1070                 1075                 1080             


Ala Arg  Gly Glu Arg Asn Leu  Leu Tyr Ile Val Val  Val Asp Gly 
    1085                 1090                 1095             


Lys Gly  Asn Ile Val Glu Gln  Tyr Ser Leu Asn Glu  Ile Ile Asn 
    1100                 1105                 1110             


Asn Phe  Asn Gly Ile Arg Ile  Lys Thr Asp Tyr His  Ser Leu Leu 
    1115                 1120                 1125             


Asp Lys  Lys Glu Lys Glu Arg  Phe Glu Ala Arg Gln  Asn Trp Thr 
    1130                 1135                 1140             


Ser Ile  Glu Asn Ile Lys Glu  Leu Lys Ala Gly Tyr  Ile Ser Gln 
    1145                 1150                 1155             


Val Val  His Lys Ile Cys Glu  Leu Val Glu Lys Tyr  Asp Ala Val 
    1160                 1165                 1170             


Ile Ala  Leu Glu Asp Leu Asn  Ser Gly Phe Lys Asn  Ser Arg Val 
    1175                 1180                 1185             


Lys Val  Glu Lys Gln Val Tyr  Gln Lys Phe Glu Lys  Met Leu Ile 
    1190                 1195                 1200             


Asp Lys  Leu Asn Tyr Met Val  Asp Lys Lys Ser Asn  Pro Cys Ala 
    1205                 1210                 1215             


Thr Gly  Gly Ala Leu Lys Gly  Tyr Gln Ile Thr Asn  Lys Phe Glu 
    1220                 1225                 1230             


Ser Phe  Lys Ser Met Ser Thr  Gln Asn Gly Phe Ile  Phe Tyr Ile 
    1235                 1240                 1245             


Pro Ala  Trp Leu Thr Ser Lys  Ile Asp Pro Ser Thr  Gly Phe Val 
    1250                 1255                 1260             


Asn Leu  Leu Lys Thr Lys Tyr  Thr Ser Ile Ala Asp  Ser Lys Lys 
    1265                 1270                 1275             


Phe Ile  Ser Ser Phe Asp Arg  Ile Met Tyr Val Pro  Glu Glu Asp 
    1280                 1285                 1290             


Leu Phe  Glu Phe Ala Leu Asp  Tyr Lys Asn Phe Ser  Arg Thr Asp 
    1295                 1300                 1305             


Ala Asp  Tyr Ile Lys Lys Trp  Lys Leu Tyr Ser Tyr  Gly Asn Arg 
    1310                 1315                 1320             


Ile Arg  Ile Phe Arg Asn Pro  Lys Lys Asn Asn Val  Phe Asp Trp 
    1325                 1330                 1335             


Glu Glu  Val Cys Leu Thr Ser  Ala Tyr Lys Glu Leu  Phe Asn Lys 
    1340                 1345                 1350             


Tyr Gly  Ile Asn Tyr Gln Gln  Gly Asp Ile Arg Ala  Leu Leu Cys 
    1355                 1360                 1365             


Glu Gln  Ser Asp Lys Ala Phe  Tyr Ser Ser Phe Met  Ala Leu Met 
    1370                 1375                 1380             


Ser Leu  Met Leu Gln Met Arg  Asn Ser Ile Thr Gly  Arg Thr Asp 
    1385                 1390                 1395             


Val Asp  Phe Leu Ile Ser Pro  Val Lys Asn Ser Asp  Gly Ile Phe 
    1400                 1405                 1410             


Tyr Asp  Ser Arg Asn Tyr Glu  Ala Gln Glu Asn Ala  Ile Leu Pro 
    1415                 1420                 1425             


Lys Asn  Ala Asp Ala Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val 
    1430                 1435                 1440             


Leu Trp  Ala Ile Gly Gln Phe  Lys Lys Ala Glu Asp  Glu Lys Leu 
    1445                 1450                 1455             


Asp Lys  Val Lys Ile Ala Ile  Ser Asn Lys Glu Trp  Leu Glu Tyr 
    1460                 1465                 1470             


Ala Gln  Thr Ser Val Lys His  Thr Arg Asp Ser Gly  Gly Ser Thr 
    1475                 1480                 1485             


Asn Leu  Ser Asp Ile Ile Glu  Lys Glu Thr Gly Lys  Gln Leu Val 
    1490                 1495                 1500             


Ile Gln  Glu Ser Ile Leu Met  Leu Pro Glu Glu Val  Glu Glu Val 
    1505                 1510                 1515             


Ile Gly  Asn Lys Pro Glu Ser  Asp Ile Leu Val His  Thr Ala Tyr 
    1520                 1525                 1530             


Asp Glu  Ser Thr Asp Glu Asn  Val Met Leu Leu Thr  Ser Asp Ala 
    1535                 1540                 1545             


Pro Glu  Tyr Lys Pro Trp Ala  Leu Val Ile Gln Asp  Ser Asn Gly 
    1550                 1555                 1560             


Glu Asn  Lys Ile Lys Met Leu  Ser Gly Gly Ser Pro  Lys Lys Lys 
    1565                 1570                 1575             


Arg Lys  Val Ser Gly Gly Ser  Pro Lys Lys Lys Arg  Lys Val 
    1580                 1585                 1590         


<210>  26
<211>  1731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dFNCPF1-ABE7.10-2NLS

<400>  26

Met Pro Lys Lys Lys Arg Lys Val Ser Gly Gly Ser Ser Glu Val Glu 
1               5                   10                  15      


Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg 
            20                  25                  30          


Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn 
        35                  40                  45              


Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp 
    50                  55                  60                  


Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val 
65                  70                  75                  80  


Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Leu Glu 
                85                  90                  95      


Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg 
            100                 105                 110         


Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu 
        115                 120                 125             


Met Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr 
    130                 135                 140                 


Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe 
145                 150                 155                 160 


Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser 
                165                 170                 175     


Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro 
            180                 185                 190         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly 
        195                 200                 205             


Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala 
    210                 215                 220                 


Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly 
225                 230                 235                 240 


Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg 
                245                 250                 255     


Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu 
            260                 265                 270         


Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr 
        275                 280                 285             


Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile 
    290                 295                 300                 


His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr 
305                 310                 315                 320 


Gly Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn 
                325                 330                 335     


His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala 
            340                 345                 350         


Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln 
        355                 360                 365             


Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser 
    370                 375                 380                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Leu Lys Ser Ile Tyr Gln Glu Phe 
                405                 410                 415     


Val Asn Lys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro 
            420                 425                 430         


Gln Gly Lys Thr Leu Glu Asn Ile Lys Ala Arg Gly Leu Ile Leu Asp 
        435                 440                 445             


Asp Glu Lys Arg Ala Lys Asp Tyr Lys Lys Ala Lys Gln Ile Ile Asp 
    450                 455                 460                 


Lys Tyr His Gln Phe Phe Ile Glu Glu Ile Leu Ser Ser Val Cys Ile 
465                 470                 475                 480 


Ser Glu Asp Leu Leu Gln Asn Tyr Ser Asp Val Tyr Phe Lys Leu Lys 
                485                 490                 495     


Lys Ser Asp Asp Asp Asn Leu Gln Lys Asp Phe Lys Ser Ala Lys Asp 
            500                 505                 510         


Thr Ile Lys Lys Gln Ile Ser Glu Tyr Ile Lys Asp Ser Glu Lys Phe 
        515                 520                 525             


Lys Asn Leu Phe Asn Gln Asn Leu Ile Asp Ala Lys Lys Gly Gln Glu 
    530                 535                 540                 


Ser Asp Leu Ile Leu Trp Leu Lys Gln Ser Lys Asp Asn Gly Ile Glu 
545                 550                 555                 560 


Leu Phe Lys Ala Asn Ser Asp Ile Thr Asp Ile Asp Glu Ala Leu Glu 
                565                 570                 575     


Ile Ile Lys Ser Phe Lys Gly Trp Thr Thr Tyr Phe Lys Gly Phe His 
            580                 585                 590         


Glu Asn Arg Lys Asn Val Tyr Ser Ser Asn Asp Ile Pro Thr Ser Ile 
        595                 600                 605             


Ile Tyr Arg Ile Val Asp Asp Asn Leu Pro Lys Phe Leu Glu Asn Lys 
    610                 615                 620                 


Ala Lys Tyr Glu Ser Leu Lys Asp Lys Ala Pro Glu Ala Ile Asn Tyr 
625                 630                 635                 640 


Glu Gln Ile Lys Lys Asp Leu Ala Glu Glu Leu Thr Phe Asp Ile Asp 
                645                 650                 655     


Tyr Lys Thr Ser Glu Val Asn Gln Arg Val Phe Ser Leu Asp Glu Val 
            660                 665                 670         


Phe Glu Ile Ala Asn Phe Asn Asn Tyr Leu Asn Gln Ser Gly Ile Thr 
        675                 680                 685             


Lys Phe Asn Thr Ile Ile Gly Gly Lys Phe Val Asn Gly Glu Asn Thr 
    690                 695                 700                 


Lys Arg Lys Gly Ile Asn Glu Tyr Ile Asn Leu Tyr Ser Gln Gln Ile 
705                 710                 715                 720 


Asn Asp Lys Thr Leu Lys Lys Tyr Lys Met Ser Val Leu Phe Lys Gln 
                725                 730                 735     


Ile Leu Ser Asp Thr Glu Ser Lys Ser Phe Val Ile Asp Lys Leu Glu 
            740                 745                 750         


Asp Asp Ser Asp Val Val Thr Thr Met Gln Ser Phe Tyr Glu Gln Ile 
        755                 760                 765             


Ala Ala Phe Lys Thr Val Glu Glu Lys Ser Ile Lys Glu Thr Leu Ser 
    770                 775                 780                 


Leu Leu Phe Asp Asp Leu Lys Ala Gln Lys Leu Asp Leu Ser Lys Ile 
785                 790                 795                 800 


Tyr Phe Lys Asn Asp Lys Ser Leu Thr Asp Leu Ser Gln Gln Val Phe 
                805                 810                 815     


Asp Asp Tyr Ser Val Ile Gly Thr Ala Val Leu Glu Tyr Ile Thr Gln 
            820                 825                 830         


Gln Ile Ala Pro Lys Asn Leu Asp Asn Pro Ser Lys Lys Glu Gln Glu 
        835                 840                 845             


Leu Ile Ala Lys Lys Thr Glu Lys Ala Lys Tyr Leu Ser Leu Glu Thr 
    850                 855                 860                 


Ile Lys Leu Ala Leu Glu Glu Phe Asn Lys His Arg Asp Ile Asp Lys 
865                 870                 875                 880 


Gln Cys Arg Phe Glu Glu Ile Leu Ala Asn Phe Ala Ala Ile Pro Met 
                885                 890                 895     


Ile Phe Asp Glu Ile Ala Gln Asn Lys Asp Asn Leu Ala Gln Ile Ser 
            900                 905                 910         


Ile Lys Tyr Gln Asn Gln Gly Lys Lys Asp Leu Leu Gln Ala Ser Ala 
        915                 920                 925             


Glu Asp Asp Val Lys Ala Ile Lys Asp Leu Leu Asp Gln Thr Asn Asn 
    930                 935                 940                 


Leu Leu His Lys Leu Lys Ile Phe His Ile Ser Gln Ser Glu Asp Lys 
945                 950                 955                 960 


Ala Asn Ile Leu Asp Lys Asp Glu His Phe Tyr Leu Val Phe Glu Glu 
                965                 970                 975     


Cys Tyr Phe Glu Leu Ala Asn Ile Val Pro Leu Tyr Asn Lys Ile Arg 
            980                 985                 990         


Asn Tyr Ile Thr Gln Lys Pro Tyr  Ser Asp Glu Lys Phe  Lys Leu Asn 
        995                 1000                 1005             


Phe Glu  Asn Ser Thr Leu Ala  Asn Gly Trp Asp Lys  Asn Lys Glu 
    1010                 1015                 1020             


Pro Asp  Asn Thr Ala Ile Leu  Phe Ile Lys Asp Asp  Lys Tyr Tyr 
    1025                 1030                 1035             


Leu Gly  Val Met Asn Lys Lys  Asn Asn Lys Ile Phe  Asp Asp Lys 
    1040                 1045                 1050             


Ala Ile  Lys Glu Asn Lys Gly  Glu Gly Tyr Lys Lys  Ile Val Tyr 
    1055                 1060                 1065             


Lys Leu  Leu Pro Gly Ala Asn  Lys Met Leu Pro Lys  Val Phe Phe 
    1070                 1075                 1080             


Ser Ala  Lys Ser Ile Lys Phe  Tyr Asn Pro Ser Glu  Asp Ile Leu 
    1085                 1090                 1095             


Arg Ile  Arg Asn His Ser Thr  His Thr Lys Asn Gly  Ser Pro Gln 
    1100                 1105                 1110             


Lys Gly  Tyr Glu Lys Phe Glu  Phe Asn Ile Glu Asp  Cys Arg Lys 
    1115                 1120                 1125             


Phe Ile  Asp Phe Tyr Lys Gln  Ser Ile Ser Lys His  Pro Glu Trp 
    1130                 1135                 1140             


Lys Asp  Phe Gly Phe Arg Phe  Ser Asp Thr Gln Arg  Tyr Asn Ser 
    1145                 1150                 1155             


Ile Asp  Glu Phe Tyr Arg Glu  Val Glu Asn Gln Gly  Tyr Lys Leu 
    1160                 1165                 1170             


Thr Phe  Glu Asn Ile Ser Glu  Ser Tyr Ile Asp Ser  Val Val Asn 
    1175                 1180                 1185             


Gln Gly  Lys Leu Tyr Leu Phe  Gln Ile Tyr Asn Lys  Asp Phe Ser 
    1190                 1195                 1200             


Ala Tyr  Ser Lys Gly Arg Pro  Asn Leu His Thr Leu  Tyr Trp Lys 
    1205                 1210                 1215             


Ala Leu  Phe Asp Glu Arg Asn  Leu Gln Asp Val Val  Tyr Lys Leu 
    1220                 1225                 1230             


Asn Gly  Glu Ala Glu Leu Phe  Tyr Arg Lys Gln Ser  Ile Pro Lys 
    1235                 1240                 1245             


Lys Ile  Thr His Pro Ala Lys  Glu Ala Ile Ala Asn  Lys Asn Lys 
    1250                 1255                 1260             


Asp Asn  Pro Lys Lys Glu Ser  Val Phe Glu Tyr Asp  Leu Ile Lys 
    1265                 1270                 1275             


Asp Lys  Arg Phe Thr Glu Asp  Lys Phe Phe Phe His  Cys Pro Ile 
    1280                 1285                 1290             


Thr Ile  Asn Phe Lys Ser Ser  Gly Ala Asn Lys Phe  Asn Asp Glu 
    1295                 1300                 1305             


Ile Asn  Leu Leu Leu Lys Glu  Lys Ala Asn Asp Val  His Ile Leu 
    1310                 1315                 1320             


Ser Ile  Ala Arg Gly Glu Arg  His Leu Ala Tyr Tyr  Thr Leu Val 
    1325                 1330                 1335             


Asp Gly  Lys Gly Asn Ile Ile  Lys Gln Asp Thr Phe  Asn Ile Ile 
    1340                 1345                 1350             


Gly Asn  Asp Arg Met Lys Thr  Asn Tyr His Asp Lys  Leu Ala Ala 
    1355                 1360                 1365             


Ile Glu  Lys Asp Arg Asp Ser  Ala Arg Lys Asp Trp  Lys Lys Ile 
    1370                 1375                 1380             


Asn Asn  Ile Lys Glu Met Lys  Glu Gly Tyr Leu Ser  Gln Val Val 
    1385                 1390                 1395             


His Glu  Ile Ala Lys Leu Val  Ile Glu Tyr Asn Ala  Ile Val Val 
    1400                 1405                 1410             


Phe Glu  Asp Leu Asn Phe Gly  Phe Lys Arg Gly Arg  Phe Lys Val 
    1415                 1420                 1425             


Glu Lys  Gln Val Tyr Gln Lys  Leu Glu Lys Met Leu  Ile Glu Lys 
    1430                 1435                 1440             


Leu Asn  Tyr Leu Val Phe Lys  Asp Asn Glu Phe Asp  Lys Thr Gly 
    1445                 1450                 1455             


Gly Val  Leu Arg Ala Tyr Gln  Leu Thr Ala Pro Phe  Glu Thr Phe 
    1460                 1465                 1470             


Lys Lys  Met Gly Lys Gln Thr  Gly Ile Ile Tyr Tyr  Val Pro Ala 
    1475                 1480                 1485             


Gly Phe  Thr Ser Lys Ile Cys  Pro Val Thr Gly Phe  Val Asn Gln 
    1490                 1495                 1500             


Leu Tyr  Pro Lys Tyr Glu Ser  Val Ser Lys Ser Gln  Glu Phe Phe 
    1505                 1510                 1515             


Ser Lys  Phe Asp Lys Ile Cys  Tyr Asn Leu Asp Lys  Gly Tyr Phe 
    1520                 1525                 1530             


Glu Phe  Ser Phe Asp Tyr Lys  Asn Phe Gly Asp Lys  Ala Ala Lys 
    1535                 1540                 1545             


Gly Lys  Trp Thr Ile Ala Ser  Phe Gly Ser Arg Leu  Ile Asn Phe 
    1550                 1555                 1560             


Arg Asn  Ser Asp Lys Asn His  Asn Trp Asp Thr Arg  Glu Val Tyr 
    1565                 1570                 1575             


Pro Thr  Lys Glu Leu Glu Lys  Leu Leu Lys Asp Tyr  Ser Ile Glu 
    1580                 1585                 1590             


Tyr Gly  His Gly Glu Cys Ile  Lys Ala Ala Ile Cys  Gly Glu Ser 
    1595                 1600                 1605             


Asp Lys  Lys Phe Phe Ala Lys  Leu Thr Ser Val Leu  Asn Thr Ile 
    1610                 1615                 1620             


Leu Gln  Met Arg Asn Ser Lys  Thr Gly Thr Glu Leu  Asp Tyr Leu 
    1625                 1630                 1635             


Ile Ser  Pro Val Ala Asp Val  Asn Gly Asn Phe Phe  Asp Ser Arg 
    1640                 1645                 1650             


Gln Ala  Pro Lys Asn Met Pro  Gln Asp Ala Asp Ala  Asn Gly Ala 
    1655                 1660                 1665             


Tyr His  Ile Gly Leu Lys Gly  Leu Met Leu Leu Gly  Arg Ile Lys 
    1670                 1675                 1680             


Asn Asn  Gln Glu Gly Lys Lys  Leu Asn Leu Val Ile  Lys Asn Glu 
    1685                 1690                 1695             


Glu Tyr  Phe Glu Phe Val Gln  Asn Arg Asn Asn Ser  Gly Gly Ser 
    1700                 1705                 1710             


Pro Lys  Lys Lys Arg Lys Val  Ser Gly Gly Ser Pro  Lys Lys Lys 
    1715                 1720                 1725             


Arg Lys  Val 
    1730     


<210>  27
<211>  1659
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  dLBCPF1-ABE7.10-2NLS

<400>  27

Met Pro Lys Lys Lys Arg Lys Val Ser Gly Gly Ser Ser Glu Val Glu 
1               5                   10                  15      


Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg 
            20                  25                  30          


Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn 
        35                  40                  45              


Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp 
    50                  55                  60                  


Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val 
65                  70                  75                  80  


Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Leu Glu 
                85                  90                  95      


Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg 
            100                 105                 110         


Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu 
        115                 120                 125             


Met Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr 
    130                 135                 140                 


Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe 
145                 150                 155                 160 


Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser 
                165                 170                 175     


Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro 
            180                 185                 190         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly 
        195                 200                 205             


Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala 
    210                 215                 220                 


Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly 
225                 230                 235                 240 


Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg 
                245                 250                 255     


Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu 
            260                 265                 270         


Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr 
        275                 280                 285             


Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile 
    290                 295                 300                 


His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr 
305                 310                 315                 320 


Gly Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn 
                325                 330                 335     


His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala 
            340                 345                 350         


Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln 
        355                 360                 365             


Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser 
    370                 375                 380                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Leu Lys Ser Lys Leu Glu Lys Phe 
                405                 410                 415     


Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro 
            420                 425                 430         


Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu 
        435                 440                 445             


Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp 
    450                 455                 460                 


Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu 
465                 470                 475                 480 


Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr 
                485                 490                 495     


Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys 
            500                 505                 510         


Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe 
        515                 520                 525             


Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys 
    530                 535                 540                 


Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe 
545                 550                 555                 560 


Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys 
                565                 570                 575     


Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr 
            580                 585                 590         


Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys 
        595                 600                 605             


His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp 
    610                 615                 620                 


Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln 
625                 630                 635                 640 


Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu 
                645                 650                 655     


Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn 
            660                 665                 670         


Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln 
        675                 680                 685             


Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr 
    690                 695                 700                 


Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn Lys Asn 
705                 710                 715                 720 


Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn 
                725                 730                 735     


Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly Pro Ala 
            740                 745                 750         


Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val Ile Arg 
        755                 760                 765             


Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys Lys Ala 
    770                 775                 780                 


Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys 
785                 790                 795                 800 


Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp 
                805                 810                 815     


Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys Val Asp 
            820                 825                 830         


Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp 
        835                 840                 845             


Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val Ala Ile 
    850                 855                 860                 


Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys 
865                 870                 875                 880 


Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr 
                885                 890                 895     


Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp His Ile 
            900                 905                 910         


Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp 
        915                 920                 925             


Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly Trp Asp 
    930                 935                 940                 


Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr Gly Ser 
945                 950                 955                 960 


Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys Leu Gln 
                965                 970                 975     


Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile Asn Tyr 
            980                 985                 990         


Lys Leu Leu Pro Gly Pro Asn Lys  Met Leu Pro Lys Val  Phe Phe Ser 
        995                 1000                 1005             


Lys Lys  Trp Met Ala Tyr Tyr  Asn Pro Ser Glu Asp  Ile Gln Lys 
    1010                 1015                 1020             


Ile Tyr  Lys Asn Gly Thr Phe  Lys Lys Gly Asp Met  Phe Asn Leu 
    1025                 1030                 1035             


Asn Asp  Cys His Lys Leu Ile  Asp Phe Phe Lys Asp  Ser Ile Ser 
    1040                 1045                 1050             


Arg Tyr  Pro Lys Trp Ser Asn  Ala Tyr Asp Phe Asn  Phe Ser Glu 
    1055                 1060                 1065             


Thr Glu  Lys Tyr Lys Asp Ile  Ala Gly Phe Tyr Arg  Glu Val Glu 
    1070                 1075                 1080             


Glu Gln  Gly Tyr Lys Val Ser  Phe Glu Ser Ala Ser  Lys Lys Glu 
    1085                 1090                 1095             


Val Asp  Lys Leu Val Glu Glu  Gly Lys Leu Tyr Met  Phe Gln Ile 
    1100                 1105                 1110             


Tyr Asn  Lys Asp Phe Ser Asp  Lys Ser His Gly Thr  Pro Asn Leu 
    1115                 1120                 1125             


His Thr  Met Tyr Phe Lys Leu  Leu Phe Asp Glu Asn  Asn His Gly 
    1130                 1135                 1140             


Gln Ile  Arg Leu Ser Gly Gly  Ala Glu Leu Phe Met  Arg Arg Ala 
    1145                 1150                 1155             


Ser Leu  Lys Lys Glu Glu Leu  Val Val His Pro Ala  Asn Ser Pro 
    1160                 1165                 1170             


Ile Ala  Asn Lys Asn Pro Asp  Asn Pro Lys Lys Thr  Thr Thr Leu 
    1175                 1180                 1185             


Ser Tyr  Asp Val Tyr Lys Asp  Lys Arg Phe Ser Glu  Asp Gln Tyr 
    1190                 1195                 1200             


Glu Leu  His Ile Pro Ile Ala  Ile Asn Lys Cys Pro  Lys Asn Ile 
    1205                 1210                 1215             


Phe Lys  Ile Asn Thr Glu Val  Arg Val Leu Leu Lys  His Asp Asp 
    1220                 1225                 1230             


Asn Pro  Tyr Val Ile Gly Ile  Ala Arg Gly Glu Arg  Asn Leu Leu 
    1235                 1240                 1245             


Tyr Ile  Val Val Val Asp Gly  Lys Gly Asn Ile Val  Glu Gln Tyr 
    1250                 1255                 1260             


Ser Leu  Asn Glu Ile Ile Asn  Asn Phe Asn Gly Ile  Arg Ile Lys 
    1265                 1270                 1275             


Thr Asp  Tyr His Ser Leu Leu  Asp Lys Lys Glu Lys  Glu Arg Phe 
    1280                 1285                 1290             


Glu Ala  Arg Gln Asn Trp Thr  Ser Ile Glu Asn Ile  Lys Glu Leu 
    1295                 1300                 1305             


Lys Ala  Gly Tyr Ile Ser Gln  Val Val His Lys Ile  Cys Glu Leu 
    1310                 1315                 1320             


Val Glu  Lys Tyr Asp Ala Val  Ile Ala Leu Glu Asp  Leu Asn Ser 
    1325                 1330                 1335             


Gly Phe  Lys Asn Ser Arg Val  Lys Val Glu Lys Gln  Val Tyr Gln 
    1340                 1345                 1350             


Lys Phe  Glu Lys Met Leu Ile  Asp Lys Leu Asn Tyr  Met Val Asp 
    1355                 1360                 1365             


Lys Lys  Ser Asn Pro Cys Ala  Thr Gly Gly Ala Leu  Lys Gly Tyr 
    1370                 1375                 1380             


Gln Ile  Thr Asn Lys Phe Glu  Ser Phe Lys Ser Met  Ser Thr Gln 
    1385                 1390                 1395             


Asn Gly  Phe Ile Phe Tyr Ile  Pro Ala Trp Leu Thr  Ser Lys Ile 
    1400                 1405                 1410             


Asp Pro  Ser Thr Gly Phe Val  Asn Leu Leu Lys Thr  Lys Tyr Thr 
    1415                 1420                 1425             


Ser Ile  Ala Asp Ser Lys Lys  Phe Ile Ser Ser Phe  Asp Arg Ile 
    1430                 1435                 1440             


Met Tyr  Val Pro Glu Glu Asp  Leu Phe Glu Phe Ala  Leu Asp Tyr 
    1445                 1450                 1455             


Lys Asn  Phe Ser Arg Thr Asp  Ala Asp Tyr Ile Lys  Lys Trp Lys 
    1460                 1465                 1470             


Leu Tyr  Ser Tyr Gly Asn Arg  Ile Arg Ile Phe Arg  Asn Pro Lys 
    1475                 1480                 1485             


Lys Asn  Asn Val Phe Asp Trp  Glu Glu Val Cys Leu  Thr Ser Ala 
    1490                 1495                 1500             


Tyr Lys  Glu Leu Phe Asn Lys  Tyr Gly Ile Asn Tyr  Gln Gln Gly 
    1505                 1510                 1515             


Asp Ile  Arg Ala Leu Leu Cys  Glu Gln Ser Asp Lys  Ala Phe Tyr 
    1520                 1525                 1530             


Ser Ser  Phe Met Ala Leu Met  Ser Leu Met Leu Gln  Met Arg Asn 
    1535                 1540                 1545             


Ser Ile  Thr Gly Arg Thr Asp  Val Asp Phe Leu Ile  Ser Pro Val 
    1550                 1555                 1560             


Lys Asn  Ser Asp Gly Ile Phe  Tyr Asp Ser Arg Asn  Tyr Glu Ala 
    1565                 1570                 1575             


Gln Glu  Asn Ala Ile Leu Pro  Lys Asn Ala Asp Ala  Asn Gly Ala 
    1580                 1585                 1590             


Tyr Asn  Ile Ala Arg Lys Val  Leu Trp Ala Ile Gly  Gln Phe Lys 
    1595                 1600                 1605             


Lys Ala  Glu Asp Glu Lys Leu  Asp Lys Val Lys Ile  Ala Ile Ser 
    1610                 1615                 1620             


Asn Lys  Glu Trp Leu Glu Tyr  Ala Gln Thr Ser Val  Lys His Ser 
    1625                 1630                 1635             


Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val Ser Gly  Gly Ser Pro 
    1640                 1645                 1650             


Lys Lys  Lys Arg Lys Val 
    1655                 


<210>  28
<211>  1656
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   LBCPF1-ABE2-X2

<400>  28

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Ala 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His Lys Leu  Met Pro Lys 
    1220                 1225                 1230             


Lys Lys  Arg Lys Val Ser Gly  Gly Ser Ser Glu Val  Glu Phe Ser 
    1235                 1240                 1245             


His Glu  Tyr Trp Met Arg His  Ala Leu Thr Leu Ala  Lys Arg Ala 
    1250                 1255                 1260             


Trp Asp  Glu Arg Glu Val Pro  Val Gly Ala Val Leu  Val His Asn 
    1265                 1270                 1275             


Asn Arg  Val Ile Gly Glu Gly  Trp Asn Arg Pro Ile  Gly Arg His 
    1280                 1285                 1290             


Asp Pro  Thr Ala His Ala Glu  Ile Met Ala Leu Arg  Gln Gly Gly 
    1295                 1300                 1305             


Leu Val  Met Gln Asn Tyr Arg  Leu Ile Asp Ala Thr  Leu Tyr Val 
    1310                 1315                 1320             


Thr Leu  Glu Pro Cys Val Met  Cys Ala Gly Ala Met  Ile His Ser 
    1325                 1330                 1335             


Arg Ile  Gly Arg Val Val Phe  Gly Ala Arg Asp Ala  Lys Thr Gly 
    1340                 1345                 1350             


Ala Ala  Gly Ser Leu Met Asp  Val Leu His His Pro  Gly Met Asn 
    1355                 1360                 1365             


His Arg  Val Glu Ile Thr Glu  Gly Ile Leu Ala Asp  Glu Cys Ala 
    1370                 1375                 1380             


Ala Leu  Leu Ser Asp Phe Phe  Arg Met Arg Arg Gln  Glu Ile Lys 
    1385                 1390                 1395             


Ala Gln  Lys Lys Ala Gln Ser  Ser Thr Asp Ser Gly  Gly Ser Ser 
    1400                 1405                 1410             


Gly Gly  Ser Ser Gly Ser Glu  Thr Pro Gly Thr Ser  Glu Ser Ala 
    1415                 1420                 1425             


Thr Pro  Glu Ser Ser Gly Gly  Ser Ser Gly Gly Ser  Ser Glu Val 
    1430                 1435                 1440             


Glu Phe  Ser His Glu Tyr Trp  Met Arg His Ala Leu  Thr Leu Ala 
    1445                 1450                 1455             


Lys Arg  Ala Arg Asp Glu Arg  Glu Val Pro Val Gly  Ala Val Leu 
    1460                 1465                 1470             


Val Leu  Asn Asn Arg Val Ile  Gly Glu Gly Trp Asn  Arg Ala Ile 
    1475                 1480                 1485             


Gly Leu  His Asp Pro Thr Ala  His Ala Glu Ile Met  Ala Leu Arg 
    1490                 1495                 1500             


Gln Gly  Gly Leu Val Met Gln  Asn Tyr Arg Leu Ile  Asp Ala Thr 
    1505                 1510                 1515             


Leu Tyr  Val Thr Phe Glu Pro  Cys Val Met Cys Ala  Gly Ala Met 
    1520                 1525                 1530             


Ile His  Ser Arg Ile Gly Arg  Val Val Phe Gly Val  Arg Asn Ala 
    1535                 1540                 1545             


Lys Thr  Gly Ala Ala Gly Ser  Leu Met Asp Val Leu  His Tyr Pro 
    1550                 1555                 1560             


Gly Met  Asn His Arg Val Glu  Ile Thr Glu Gly Ile  Leu Ala Asp 
    1565                 1570                 1575             


Glu Cys  Ala Ala Leu Leu Cys  Tyr Phe Phe Arg Met  Pro Arg Gln 
    1580                 1585                 1590             


Val Phe  Asn Ala Gln Lys Lys  Ala Gln Ser Ser Thr  Asp Ser Gly 
    1595                 1600                 1605             


Gly Ser  Ser Gly Gly Ser Ser  Gly Ser Glu Thr Pro  Gly Thr Ser 
    1610                 1615                 1620             


Glu Ser  Ala Thr Pro Glu Ser  Ser Gly Gly Ser Ser  Gly Gly Ser 
    1625                 1630                 1635             


Leu Lys  Lys Arg Pro Ala Ala  Thr Lys Lys Ala Gly  Gln Ala Lys 
    1640                 1645                 1650             


Lys Lys  Lys 
    1655     


<210>  29
<211>  1663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LBCPF1-ABE2-X3

<400>  29

Met Pro Lys Lys Lys Arg Lys Val Ser Lys Leu Glu Lys Phe Thr Asn 
1               5                   10                  15      


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
            20                  25                  30          


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
        35                  40                  45              


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
    50                  55                  60                  


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
65                  70                  75                  80  


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
                85                  90                  95      


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
            100                 105                 110         


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
        115                 120                 125             


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
    130                 135                 140                 


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
145                 150                 155                 160 


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
                165                 170                 175     


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
            180                 185                 190         


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
        195                 200                 205             


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
    210                 215                 220                 


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
225                 230                 235                 240 


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
                245                 250                 255     


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
            260                 265                 270         


Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu 
        275                 280                 285             


Ser Asp Arg Glu Ser Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp 
    290                 295                 300                 


Glu Glu Val Leu Glu Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu 
305                 310                 315                 320 


Ile Phe Ser Ser Ile Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp 
                325                 330                 335     


Glu Tyr Ser Ser Ala Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser 
            340                 345                 350         


Thr Ile Ser Lys Asp Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys 
        355                 360                 365             


Trp Asn Ala Glu Tyr Asp Asp Ile His Leu Lys Lys Lys Ala Val Val 
    370                 375                 380                 


Thr Glu Lys Tyr Glu Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly 
385                 390                 395                 400 


Ser Phe Ser Leu Glu Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser 
                405                 410                 415     


Val Val Glu Lys Leu Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile 
            420                 425                 430         


Tyr Lys Val Tyr Gly Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val 
        435                 440                 445             


Leu Glu Lys Ser Leu Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys 
    450                 455                 460                 


Asp Leu Leu Asp Ser Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe 
465                 470                 475                 480 


Phe Gly Glu Gly Lys Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp 
                485                 490                 495     


Phe Val Leu Ala Tyr Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp 
            500                 505                 510         


Ala Ile Arg Asn Tyr Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe 
        515                 520                 525             


Lys Leu Tyr Phe Gln Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp 
    530                 535                 540                 


Lys Glu Thr Asp Tyr Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr 
545                 550                 555                 560 


Tyr Leu Ala Ile Met Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile 
                565                 570                 575     


Asp Lys Asp Asp Val Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu 
            580                 585                 590         


Leu Pro Gly Pro Asn Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys 
        595                 600                 605             


Trp Met Ala Tyr Tyr Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys 
    610                 615                 620                 


Asn Gly Thr Phe Lys Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His 
625                 630                 635                 640 


Lys Leu Ile Asp Phe Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp 
                645                 650                 655     


Ser Asn Ala Tyr Asp Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp 
            660                 665                 670         


Ile Ala Gly Phe Tyr Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser 
        675                 680                 685             


Phe Glu Ser Ala Ser Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly 
    690                 695                 700                 


Lys Leu Tyr Met Phe Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser 
705                 710                 715                 720 


His Gly Thr Pro Asn Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp 
                725                 730                 735     


Glu Asn Asn His Gly Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe 
            740                 745                 750         


Met Arg Arg Ala Ser Leu Lys Lys Glu Glu Leu Val Val His Pro Ala 
        755                 760                 765             


Asn Ser Pro Ile Ala Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr 
    770                 775                 780                 


Thr Leu Ser Tyr Asp Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln 
785                 790                 795                 800 


Tyr Glu Leu His Ile Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile 
                805                 810                 815     


Phe Lys Ile Asn Thr Glu Val Arg Val Leu Leu Lys His Asp Asp Asn 
            820                 825                 830         


Pro Tyr Val Ile Gly Ile Ala Arg Gly Glu Arg Asn Leu Leu Tyr Ile 
        835                 840                 845             


Val Val Val Asp Gly Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn 
    850                 855                 860                 


Glu Ile Ile Asn Asn Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His 
865                 870                 875                 880 


Ser Leu Leu Asp Lys Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn 
                885                 890                 895     


Trp Thr Ser Ile Glu Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser 
            900                 905                 910         


Gln Val Val His Lys Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val 
        915                 920                 925             


Ile Ala Leu Glu Asp Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys 
    930                 935                 940                 


Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys 
945                 950                 955                 960 


Leu Asn Tyr Met Val Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly 
                965                 970                 975     


Ala Leu Lys Gly Tyr Gln Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser 
            980                 985                 990         


Met Ser Thr Gln Asn Gly Phe Ile  Phe Tyr Ile Pro Ala  Trp Leu Thr 
        995                 1000                 1005             


Ser Lys  Ile Asp Pro Ser Thr  Gly Phe Val Asn Leu  Leu Lys Thr 
    1010                 1015                 1020             


Lys Tyr  Thr Ser Ile Ala Asp  Ser Lys Lys Phe Ile  Ser Ser Phe 
    1025                 1030                 1035             


Asp Arg  Ile Met Tyr Val Pro  Glu Glu Asp Leu Phe  Glu Phe Ala 
    1040                 1045                 1050             


Leu Asp  Tyr Lys Asn Phe Ser  Arg Thr Asp Ala Asp  Tyr Ile Lys 
    1055                 1060                 1065             


Lys Trp  Lys Leu Tyr Ser Tyr  Gly Asn Arg Ile Arg  Ile Phe Arg 
    1070                 1075                 1080             


Asn Pro  Lys Lys Asn Asn Val  Phe Asp Trp Glu Glu  Val Cys Leu 
    1085                 1090                 1095             


Thr Ser  Ala Tyr Lys Glu Leu  Phe Asn Lys Tyr Gly  Ile Asn Tyr 
    1100                 1105                 1110             


Gln Gln  Gly Asp Ile Arg Ala  Leu Leu Cys Glu Gln  Ser Asp Lys 
    1115                 1120                 1125             


Ala Phe  Tyr Ser Ser Phe Met  Ala Leu Met Ser Leu  Met Leu Gln 
    1130                 1135                 1140             


Met Arg  Asn Ser Ile Thr Gly  Arg Thr Asp Val Asp  Phe Leu Ile 
    1145                 1150                 1155             


Ser Pro  Val Lys Asn Ser Asp  Gly Ile Phe Tyr Asp  Ser Arg Asn 
    1160                 1165                 1170             


Tyr Glu  Ala Gln Glu Asn Ala  Ile Leu Pro Lys Asn  Ala Asp Ala 
    1175                 1180                 1185             


Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val Leu Trp  Ala Ile Gly 
    1190                 1195                 1200             


Gln Phe  Lys Lys Ala Glu Asp  Glu Lys Leu Asp Lys  Val Lys Ile 
    1205                 1210                 1215             


Ala Ile  Ser Asn Lys Glu Trp  Leu Glu Tyr Ala Gln  Thr Ser Val 
    1220                 1225                 1230             


Lys His  Lys Leu Met Pro Lys  Lys Lys Arg Lys Val  Ser Gly Gly 
    1235                 1240                 1245             


Ser Ser  Glu Val Glu Phe Ser  His Glu Tyr Trp Met  Arg His Ala 
    1250                 1255                 1260             


Leu Thr  Leu Ala Lys Arg Ala  Trp Asp Glu Arg Glu  Val Pro Val 
    1265                 1270                 1275             


Gly Ala  Val Leu Val His Asn  Asn Arg Val Ile Gly  Glu Gly Trp 
    1280                 1285                 1290             


Asn Arg  Pro Ile Gly Arg His  Asp Pro Thr Ala His  Ala Glu Ile 
    1295                 1300                 1305             


Met Ala  Leu Arg Gln Gly Gly  Leu Val Met Gln Asn  Tyr Arg Leu 
    1310                 1315                 1320             


Ile Asp  Ala Thr Leu Tyr Val  Thr Leu Glu Pro Cys  Val Met Cys 
    1325                 1330                 1335             


Ala Gly  Ala Met Ile His Ser  Arg Ile Gly Arg Val  Val Phe Gly 
    1340                 1345                 1350             


Ala Arg  Asp Ala Lys Thr Gly  Ala Ala Gly Ser Leu  Met Asp Val 
    1355                 1360                 1365             


Leu His  His Pro Gly Met Asn  His Arg Val Glu Ile  Thr Glu Gly 
    1370                 1375                 1380             


Ile Leu  Ala Asp Glu Cys Ala  Ala Leu Leu Ser Asp  Phe Phe Arg 
    1385                 1390                 1395             


Met Arg  Arg Gln Glu Ile Lys  Ala Gln Lys Lys Ala  Gln Ser Ser 
    1400                 1405                 1410             


Thr Asp  Ser Gly Gly Ser Ser  Gly Gly Ser Ser Gly  Ser Glu Thr 
    1415                 1420                 1425             


Pro Gly  Thr Ser Glu Ser Ala  Thr Pro Glu Ser Ser  Gly Gly Ser 
    1430                 1435                 1440             


Ser Gly  Gly Ser Ser Glu Val  Glu Phe Ser His Glu  Tyr Trp Met 
    1445                 1450                 1455             


Arg His  Ala Leu Thr Leu Ala  Lys Arg Ala Arg Asp  Glu Arg Glu 
    1460                 1465                 1470             


Val Pro  Val Gly Ala Val Leu  Val Leu Asn Asn Arg  Val Ile Gly 
    1475                 1480                 1485             


Glu Gly  Trp Asn Arg Ala Ile  Gly Leu His Asp Pro  Thr Ala His 
    1490                 1495                 1500             


Ala Glu  Ile Met Ala Leu Arg  Gln Gly Gly Leu Val  Met Gln Asn 
    1505                 1510                 1515             


Tyr Arg  Leu Ile Asp Ala Thr  Leu Tyr Val Thr Phe  Glu Pro Cys 
    1520                 1525                 1530             


Val Met  Cys Ala Gly Ala Met  Ile His Ser Arg Ile  Gly Arg Val 
    1535                 1540                 1545             


Val Phe  Gly Val Arg Asn Ala  Lys Thr Gly Ala Ala  Gly Ser Leu 
    1550                 1555                 1560             


Met Asp  Val Leu His Tyr Pro  Gly Met Asn His Arg  Val Glu Ile 
    1565                 1570                 1575             


Thr Glu  Gly Ile Leu Ala Asp  Glu Cys Ala Ala Leu  Leu Cys Tyr 
    1580                 1585                 1590             


Phe Phe  Arg Met Pro Arg Gln  Val Phe Asn Ala Gln  Lys Lys Ala 
    1595                 1600                 1605             


Gln Ser  Ser Thr Asp Ser Gly  Gly Ser Ser Gly Gly  Ser Ser Gly 
    1610                 1615                 1620             


Ser Glu  Thr Pro Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Ser 
    1625                 1630                 1635             


Gly Gly  Ser Ser Gly Gly Ser  Leu Lys Lys Arg Pro  Ala Ala Thr 
    1640                 1645                 1650             


Lys Lys  Ala Gly Gln Ala Lys  Lys Lys Lys 
    1655                 1660             


<210>  30
<211>  1526
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  30
ctgcagtgca gcgtgacccg gtcgtgcccc tctctagaga taatgagcat tgcatgtcta       60

agttataaaa aattaccaca tatttttttt gtcacacttg tttgaagtgc agtttatcta      120

tctttataca tatatttaaa ctttactcta cgaataatat aatctatagt actacaataa      180

tatcagtgtt ttagagaatc atataaatga acagttagac atggtctaaa ggacaattga      240

gtattttgac aacaggactc tacagtttta tctttttagt gtgcatgtgt tctccttttt      300

ttttgcaaat agcttcacct atataatact tcatccattt tattagtaca tccatttagg      360

gtttagggtt aatggttttt atagactaat ttttttagta catctatttt attctatttt      420

agcctctaaa ttaagaaaac taaaactcta ttttagtttt tttatttaat aatttagata      480

taaaatagaa taaaataaag tgactaaaaa ttaaacaaat accctttaag aaattaaaaa      540

aactaaggaa acatttttct tgtttcgagt agataatgcc agcctgttaa acgccgtcga      600

tcgacgagtc taacggacac caaccagcga accagcagcg tcgcgtcggg ccaagcgaag      660

cagacggcac ggcatctctg tcgctgcctc tggacccctc tcgagagttc cgctccaccg      720

ttggacttgc tccgctgtcg gcatccagaa attgcgtggc ggagcggcag acgtgagccg      780

gcacggcagg cggcctcctc ctcctctcac ggcaccggca gctacggggg attcctttcc      840

caccgctcct tcgctttccc ttcctcgccc gccgtaataa atagacaccc cctccacacc      900

ctctttcccc aacctcgtgt tgttcggagc gcacacacac acaaccagat ctcccccaaa      960

tccacccgtc ggcacctccg cttcaaggta cgccgctcgt cctccccccc cccccctctc     1020

taccttctct agatcggcgt tccggtccat ggttagggcc cggtagttct acttctgttc     1080

atgtttgtgt tagatccgtg tttgtgttag atccgtgctg ctagcgttcg tacacggatg     1140

cgacctgtac gtcagacacg ttctgattgc taacttgcca gtgtttctct ttggggaatc     1200

ctgggatggc tctagccgtt ccgcagacgg gatcgatcta ggataggtat acatgttgat     1260

gtgggtttta ctgatgcata tacatgatgg catatgcagc atctattcat atgctctaac     1320

cttgagtacc tatctattat aataaacaag tatgttttat aattattttg atcttgatat     1380

acttggatga tggcatatgc agcagctata tgtggatttt tttagccctg ccttcatacg     1440

ctatttattt gcttggtact gtttcttttg tcgatgctca ccctgttgtt tggtgttact     1500

tctgcaggtc gaagcttgaa gcaaac                                          1526



