                         SEQUENCE LISTING

<110>  Institute of Genetics and Developmental Biology, Chinese
 
<120>  Method for base editing in plants

<130>  P20182838

<150>  201711393160.7
<151>  2017-12-21

<150>  201810402244.0
<151>  2018-04-28

<160>  139   

<170>  PatentIn version 3.5

<210>  1
<211>  166
<212>  PRT
<213>  Escherichia coli

<400>  1

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile 
        35                  40                  45              


Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  2
<211>  166
<212>  PRT
<213>  artificial sequence

<220>
<223>  mu-ecTadA (7.10)

<400>  2

Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr 
1               5                   10                  15      


Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala Val 
            20                  25                  30          


Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala Ile 
        35                  40                  45              


Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln 
    50                  55                  60                  


Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr 
65                  70                  75                  80  


Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser 
                85                  90                  95      


Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly Ala 
            100                 105                 110         


Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His Arg 
        115                 120                 125             


Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu 
    130                 135                 140                 


Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys Lys 
145                 150                 155                 160 


Ala Gln Ser Ser Thr Asp 
                165     


<210>  3
<211>  1367
<212>  PRT
<213>  artificial sequence

<220>
<223>  SPnCas9 

<400>  3

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  4
<211>  1792
<212>  PRT
<213>  artificial sequence

<220>
<223>  SPnCas9-ABE

<400>  4

Pro Lys Lys Lys Arg Lys Val Ser Gly Gly Ser Ser Glu Val Glu Phe 
1               5                   10                  15      


Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala 
            20                  25                  30          


Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn Asn 
        35                  40                  45              


Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp Pro 
    50                  55                  60                  


Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met 
65                  70                  75                  80  


Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Leu Glu Pro 
                85                  90                  95      


Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val 
            100                 105                 110         


Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu Met 
        115                 120                 125             


Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu 
    130                 135                 140                 


Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe Arg 
145                 150                 155                 160 


Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser Thr 
                165                 170                 175     


Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly 
            180                 185                 190         


Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly 
        195                 200                 205             


Ser Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
    210                 215                 220                 


Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala 
225                 230                 235                 240 


Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala 
                245                 250                 255     


Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
            260                 265                 270         


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
        275                 280                 285             


Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
    290                 295                 300                 


Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly 
305                 310                 315                 320 


Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His 
                325                 330                 335     


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
            340                 345                 350         


Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys 
        355                 360                 365             


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
    370                 375                 380                 


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
385                 390                 395                 400 


Gly Gly Ser Ser Gly Gly Ser Leu Lys Asp Lys Lys Tyr Ser Ile Gly 
                405                 410                 415     


Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
            420                 425                 430         


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
        435                 440                 445             


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
    450                 455                 460                 


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
465                 470                 475                 480 


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
                485                 490                 495     


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
            500                 505                 510         


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
        515                 520                 525             


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
    530                 535                 540                 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
545                 550                 555                 560 


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
                565                 570                 575     


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
            580                 585                 590         


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
        595                 600                 605             


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
    610                 615                 620                 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
625                 630                 635                 640 


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
                645                 650                 655     


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
            660                 665                 670         


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
        675                 680                 685             


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
    690                 695                 700                 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
705                 710                 715                 720 


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
                725                 730                 735     


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
            740                 745                 750         


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
        755                 760                 765             


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
    770                 775                 780                 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
785                 790                 795                 800 


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                805                 810                 815     


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
            820                 825                 830         


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
        835                 840                 845             


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
    850                 855                 860                 


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
865                 870                 875                 880 


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
                885                 890                 895     


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
            900                 905                 910         


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
        915                 920                 925             


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
    930                 935                 940                 


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
945                 950                 955                 960 


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
                965                 970                 975     


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
            980                 985                 990         


Asp Arg Phe Asn Ala Ser Leu Gly  Thr Tyr His Asp Leu  Leu Lys Ile 
        995                 1000                 1005             


Ile Lys  Asp Lys Asp Phe Leu  Asp Asn Glu Glu Asn  Glu Asp Ile 
    1010                 1015                 1020             


Leu Glu  Asp Ile Val Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu 
    1025                 1030                 1035             


Met Ile  Glu Glu Arg Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp 
    1040                 1045                 1050             


Lys Val  Met Lys Gln Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly 
    1055                 1060                 1065             


Arg Leu  Ser Arg Lys Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser 
    1070                 1075                 1080             


Gly Lys  Thr Ile Leu Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn 
    1085                 1090                 1095             


Arg Asn  Phe Met Gln Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys 
    1100                 1105                 1110             


Glu Asp  Ile Gln Lys Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu 
    1115                 1120                 1125             


His Glu  His Ile Ala Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys 
    1130                 1135                 1140             


Gly Ile  Leu Gln Thr Val Lys  Val Val Asp Glu Leu  Val Lys Val 
    1145                 1150                 1155             


Met Gly  Arg His Lys Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg 
    1160                 1165                 1170             


Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg 
    1175                 1180                 1185             


Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile 
    1190                 1195                 1200             


Leu Lys  Glu His Pro Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys 
    1205                 1210                 1215             


Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp 
    1220                 1225                 1230             


Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His 
    1235                 1240                 1245             


Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys 
    1250                 1255                 1260             


Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val 
    1265                 1270                 1275             


Pro Ser  Glu Glu Val Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln 
    1280                 1285                 1290             


Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu 
    1295                 1300                 1305             


Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly 
    1310                 1315                 1320             


Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg Gln Ile  Thr Lys His 
    1325                 1330                 1335             


Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu 
    1340                 1345                 1350             


Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser 
    1355                 1360                 1365             


Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val 
    1370                 1375                 1380             


Arg Glu  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    1385                 1390                 1395             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1400                 1405                 1410             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1415                 1420                 1425             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1430                 1435                 1440             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1445                 1450                 1455             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1460                 1465                 1470             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    1475                 1480                 1485             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    1490                 1495                 1500             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1505                 1510                 1515             


Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp 
    1520                 1525                 1530             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala 
    1535                 1540                 1545             


Tyr Ser  Val Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys 
    1550                 1555                 1560             


Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu 
    1565                 1570                 1575             


Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys 
    1580                 1585                 1590             


Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys 
    1595                 1600                 1605             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala 
    1610                 1615                 1620             


Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser 
    1625                 1630                 1635             


Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu 
    1640                 1645                 1650             


Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu 
    1655                 1660                 1665             


Gln His  Lys His Tyr Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu 
    1670                 1675                 1680             


Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val 
    1685                 1690                 1695             


Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln 
    1700                 1705                 1710             


Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala 
    1715                 1720                 1725             


Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg 
    1730                 1735                 1740             


Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala Thr Leu  Ile His Gln 
    1745                 1750                 1755             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1760                 1765                 1770             


Gly Gly  Asp Lys Arg Pro Ala  Ala Thr Lys Lys Ala  Gly Gln Ala 
    1775                 1780                 1785             


Lys Lys  Lys Lys 
    1790         


<210>  5
<211>  1777
<212>  PRT
<213>  artificial sequence

<220>
<223>  SPnCas9-ABE-1

<400>  5

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Leu Lys Asp 
385                 390                 395                 400 


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
                405                 410                 415     


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
            420                 425                 430         


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
        435                 440                 445             


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
    450                 455                 460                 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
465                 470                 475                 480 


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
                485                 490                 495     


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
            500                 505                 510         


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
        515                 520                 525             


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
    530                 535                 540                 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
545                 550                 555                 560 


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
                565                 570                 575     


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
            580                 585                 590         


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
        595                 600                 605             


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
    610                 615                 620                 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
625                 630                 635                 640 


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
                645                 650                 655     


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
            660                 665                 670         


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
        675                 680                 685             


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
    690                 695                 700                 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
705                 710                 715                 720 


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
                725                 730                 735     


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
            740                 745                 750         


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
        755                 760                 765             


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
    770                 775                 780                 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
785                 790                 795                 800 


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
                805                 810                 815     


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
            820                 825                 830         


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
        835                 840                 845             


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
    850                 855                 860                 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
865                 870                 875                 880 


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
                885                 890                 895     


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
            900                 905                 910         


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
        915                 920                 925             


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
    930                 935                 940                 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
945                 950                 955                 960 


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
                965                 970                 975     


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
            980                 985                 990         


His Asp Leu Leu Lys Ile Ile Lys  Asp Lys Asp Phe Leu  Asp Asn Glu 
        995                 1000                 1005             


Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val Leu Thr  Leu Thr Leu 
    1010                 1015                 1020             


Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg Leu Lys  Thr Tyr Ala 
    1025                 1030                 1035             


His Leu  Phe Asp Asp Lys Val  Met Lys Gln Leu Lys  Arg Arg Arg 
    1040                 1045                 1050             


Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys Leu Ile  Asn Gly Ile 
    1055                 1060                 1065             


Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu Asp Phe  Leu Lys Ser 
    1070                 1075                 1080             


Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln Leu Ile  His Asp Asp 
    1085                 1090                 1095             


Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys Ala Gln  Val Ser Gly 
    1100                 1105                 1110             


Gln Gly  Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
    1115                 1120                 1125             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1145                 1150                 1155             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1160                 1165                 1170             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1175                 1180                 1185             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1190                 1195                 1200             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1205                 1210                 1215             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1220                 1225                 1230             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1235                 1240                 1245             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1250                 1255                 1260             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1265                 1270                 1275             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1280                 1285                 1290             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1295                 1300                 1305             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1310                 1315                 1320             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1325                 1330                 1335             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1340                 1345                 1350             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1355                 1360                 1365             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1370                 1375                 1380             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1385                 1390                 1395             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1400                 1405                 1410             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1415                 1420                 1425             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1430                 1435                 1440             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1445                 1450                 1455             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1460                 1465                 1470             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1475                 1480                 1485             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1490                 1495                 1500             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1505                 1510                 1515             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1520                 1525                 1530             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1535                 1540                 1545             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1550                 1555                 1560             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1565                 1570                 1575             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1580                 1585                 1590             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1595                 1600                 1605             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1610                 1615                 1620             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1625                 1630                 1635             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1640                 1645                 1650             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1655                 1660                 1665             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1670                 1675                 1680             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1685                 1690                 1695             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1700                 1705                 1710             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1715                 1720                 1725             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1730                 1735                 1740             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1745                 1750                 1755             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Pro Lys Lys 
    1760                 1765                 1770             


Lys Arg  Lys Val 
    1775         


<210>  6
<211>  5379
<212>  DNA
<213>  artificial sequence

<220>
<223>   nCas9-ABE

<400>  6
atgccaaaaa agaagagaaa ggtttcaggc ggctcctccg aggtggagtt ctctcacgag       60

tattggatga ggcacgctct tacacttgct aagagagctt gggacgaaag agaagtgcca      120

gttggcgccg ttcttgtgca taataatagg gtgatcggcg agggttggaa tagaccaatt      180

ggaaggcatg atccaacagc tcacgcagag attatggctc tcagacaagg cggcctcgtt      240

atgcagaact acaggctcat tgacgctaca ctctacgtga cactcgaacc ttgcgttatg      300

tgcgccggag ctatgattca ttctaggatt ggcagggtcg tgtttggagc tagggacgct      360

aaaacaggag ccgccggatc tcttatggac gtgttgcatc atccaggcat gaaccatagg      420

gtggagatta cagagggcat tcttgcagac gagtgcgctg ctcttctttc cgatttcttc      480

aggatgagaa ggcaggagat taaggcccag aagaaggctc agtcttctac agatagcgga      540

ggatcttccg gaggatctag cggctccgag acaccaggaa catccgaaag cgctacacca      600

gaatctagcg gaggctcttc cggaggatct tctgaagtgg agttctccca cgagtattgg      660

atgaggcacg ctcttacact tgctaaaagg gctagggacg aaagggaagt tccagttgga      720

gctgttctcg tgctcaataa cagggtgatt ggcgagggtt ggaatagagc cattggactc      780

catgatccaa cagctcacgc agagattatg gctcttagac aaggcggcct cgttatgcag      840

aattacagac tcatcgacgc cacactctac gttaccttcg aaccttgcgt tatgtgcgcc      900

ggagctatga tccattctag gattggcagg gtcgtgttcg gcgttagaaa cgctaagaca      960

ggagctgcag gctctcttat ggacgttctt cattacccag gcatgaatca tagagtggag     1020

atcacagaag gcattcttgc agacgagtgc gcagctctcc tttgctattt cttcaggatg     1080

ccgaggcaag ttttcaacgc tcagaagaag gcccagtctt ctacagattc cggcggatct     1140

tctggaggat ctagcggctc cgagacacca ggaacatccg aatccgctac accagagtct     1200

tctggaggat ctagcggagg atctcttaag gacaagaagt actcgatcgg cctcgccatt     1260

gggactaact ctgttggctg ggccgtgatc accgacgagt acaaggtgcc ctcaaagaag     1320

ttcaaggtcc tgggcaacac cgatcggcat tccatcaaga agaatctcat tggcgctctc     1380

ctgttcgaca gcggcgagac ggctgaggct acgcggctca agcgcaccgc ccgcaggcgg     1440

tacacgcgca ggaagaatcg catctgctac ctgcaggaga ttttctccaa cgagatggcg     1500

aaggttgacg attctttctt ccacaggctg gaggagtcat tcctcgtgga ggaggataag     1560

aagcacgagc ggcatccaat cttcggcaac attgtcgacg aggttgccta ccacgagaag     1620

taccctacga tctaccatct gcggaagaag ctcgtggact ccacagataa ggcggacctc     1680

cgcctgatct acctcgctct ggcccacatg attaagttca ggggccattt cctgatcgag     1740

ggggatctca acccggacaa tagcgatgtt gacaagctgt tcatccagct cgtgcagacg     1800

tacaaccagc tcttcgagga gaaccccatt aatgcgtcag gcgtcgacgc gaaggctatc     1860

ctgtccgcta ggctctcgaa gtctcggcgc ctcgagaacc tgatcgccca gctgccgggc     1920

gagaagaaga acggcctgtt cgggaatctc attgcgctca gcctggggct cacgcccaac     1980

ttcaagtcga atttcgatct cgctgaggac gccaagctgc agctctccaa ggacacatac     2040

gacgatgacc tggataacct cctggcccag atcggcgatc agtacgcgga cctgttcctc     2100

gctgccaaga atctgtcgga cgccatcctc ctgtctgata ttctcagggt gaacaccgag     2160

attacgaagg ctccgctctc agcctccatg atcaagcgct acgacgagca ccatcaggat     2220

ctgaccctcc tgaaggcgct ggtcaggcag cagctccccg agaagtacaa ggagatcttc     2280

ttcgatcagt cgaagaacgg ctacgctggg tacattgacg gcggggcctc tcaggaggag     2340

ttctacaagt tcatcaagcc gattctggag aagatggacg gcacggagga gctgctggtg     2400

aagctcaatc gcgaggacct cctgaggaag cagcggacat tcgataacgg cagcatccca     2460

caccagattc atctcgggga gctgcacgct atcctgagga ggcaggagga cttctaccct     2520

ttcctcaagg ataaccgcga gaagatcgag aagattctga ctttcaggat cccgtactac     2580

gtcggcccac tcgctagggg caactcccgc ttcgcttgga tgacccgcaa gtcagaggag     2640

acgatcacgc cgtggaactt cgaggaggtg gtcgacaagg gcgctagcgc tcagtcgttc     2700

atcgagagga tgacgaattt cgacaagaac ctgccaaatg agaaggtgct ccctaagcac     2760

tcgctcctgt acgagtactt cacagtctac aacgagctga ctaaggtgaa gtatgtgacc     2820

gagggcatga ggaagccggc tttcctgtct ggggagcaga agaaggccat cgtggacctc     2880

ctgttcaaga ccaaccggaa ggtcacggtt aagcagctca aggaggacta cttcaagaag     2940

attgagtgct tcgattcggt cgagatctct ggcgttgagg accgcttcaa cgcctccctg     3000

gggacctacc acgatctcct gaagatcatt aaggataagg acttcctgga caacgaggag     3060

aatgaggata tcctcgagga cattgtgctg acactcactc tgttcgagga ccgggagatg     3120

atcgaggagc gcctgaagac ttacgcccat ctcttcgatg acaaggtcat gaagcagctc     3180

aagaggagga ggtacaccgg ctgggggagg ctgagcagga agctcatcaa cggcattcgg     3240

gacaagcagt ccgggaagac gatcctcgac ttcctgaaga gcgatggctt cgcgaaccgc     3300

aatttcatgc agctgattca cgatgacagc ctcacattca aggaggatat ccagaaggct     3360

caggtgagcg gccaggggga ctcgctgcac gagcatatcg cgaacctcgc tggctcgcca     3420

gctatcaaga aggggattct gcagaccgtg aaggttgtgg acgagctggt gaaggtcatg     3480

ggcaggcaca agcctgagaa catcgtcatt gagatggccc gggagaatca gaccacgcag     3540

aagggccaga agaactcacg cgagaggatg aagaggatcg aggagggcat taaggagctg     3600

gggtcccaga tcctcaagga gcacccggtg gagaacacgc agctgcagaa tgagaagctc     3660

tacctgtact acctccagaa tggccgcgat atgtatgtgg accaggagct ggatattaac     3720

aggctcagcg attacgacgt cgatcatatc gttccacagt cattcctgaa ggatgactcc     3780

attgacaaca aggtcctcac caggtcggac aagaaccggg gcaagtctga taatgttcct     3840

tcagaggagg tcgttaagaa gatgaagaac tactggcgcc agctcctgaa tgccaagctg     3900

atcacgcagc ggaagttcga taacctcaca aaggctgaga ggggcgggct ctctgagctg     3960

gacaaggcgg gcttcatcaa gaggcagctg gtcgagacac ggcagatcac taagcacgtt     4020

gcgcagattc tcgactcacg gatgaacact aagtacgatg agaatgacaa gctgatccgc     4080

gaggtgaagg tcatcaccct gaagtcaaag ctcgtctccg acttcaggaa ggatttccag     4140

ttctacaagg ttcgggagat caacaattac caccatgccc atgacgcgta cctgaacgcg     4200

gtggtcggca cagctctgat caagaagtac ccaaagctcg agagcgagtt cgtgtacggg     4260

gactacaagg tttacgatgt gaggaagatg atcgccaagt cggagcagga gattggcaag     4320

gctaccgcca agtacttctt ctactctaac attatgaatt tcttcaagac agagatcact     4380

ctggccaatg gcgagatccg gaagcgcccc ctcatcgaga cgaacggcga gacgggggag     4440

atcgtgtggg acaagggcag ggatttcgcg accgtcagga aggttctctc catgccacaa     4500

gtgaatatcg tcaagaagac agaggtccag actggcgggt tctctaagga gtcaattctg     4560

cctaagcgga acagcgacaa gctcatcgcc cgcaagaagg actgggatcc gaagaagtac     4620

ggcgggttcg acagccccac tgtggcctac tcggtcctgg ttgtggcgaa ggttgagaag     4680

ggcaagtcca agaagctcaa gagcgtgaag gagctgctgg ggatcacgat tatggagcgc     4740

tccagcttcg agaagaaccc gatcgatttc ctggaggcga agggctacaa ggaggtgaag     4800

aaggacctga tcattaagct ccccaagtac tcactcttcg agctggagaa cggcaggaag     4860

cggatgctgg cttccgctgg cgagctgcag aaggggaacg agctggctct gccgtccaag     4920

tatgtgaact tcctctacct ggcctcccac tacgagaagc tcaagggcag ccccgaggac     4980

aacgagcaga agcagctgtt cgtcgagcag cacaagcatt acctcgacga gatcattgag     5040

cagatttccg agttctccaa gcgcgtgatc ctggccgacg cgaatctgga taaggtcctc     5100

tccgcgtaca acaagcaccg cgacaagcca atcagggagc aggctgagaa tatcattcat     5160

ctcttcaccc tgacgaacct cggcgcccct gctgctttca agtacttcga cacaactatc     5220

gatcgcaaga ggtacacaag cactaaggag gtcctggacg cgaccctcat ccaccagtcg     5280

attaccggcc tctacgagac gcgcatcgac ctgtctcagc tcgggggcga caagcggcca     5340

gcggcgacga agaaggcggg gcaggcgaag aagaagaag                            5379


<210>  7
<211>  5334
<212>  DNA
<213>  artificial sequence

<220>
<223>  SpnCas9-ABE-1

<400>  7
atgtccgagg tggagttctc tcacgagtat tggatgaggc acgctcttac acttgctaag       60

agagcttggg acgaaagaga agtgccagtt ggcgccgttc ttgtgcataa taatagggtg      120

atcggcgagg gttggaatag accaattgga aggcatgatc caacagctca cgcagagatt      180

atggctctca gacaaggcgg cctcgttatg cagaactaca ggctcattga cgctacactc      240

tacgtgacac tcgaaccttg cgttatgtgc gccggagcta tgattcattc taggattggc      300

agggtcgtgt ttggagctag ggacgctaaa acaggagccg ccggatctct tatggacgtg      360

ttgcatcatc caggcatgaa ccatagggtg gagattacag agggcattct tgcagacgag      420

tgcgctgctc ttctttccga tttcttcagg atgagaaggc aggagattaa ggcccagaag      480

aaggctcagt cttctacaga tagcggagga tcttccggag gatctagcgg ctccgagaca      540

ccaggaacat ccgaaagcgc tacaccagaa tctagcggag gctcttccgg aggatcttct      600

gaagtggagt tctcccacga gtattggatg aggcacgctc ttacacttgc taaaagggct      660

agggacgaaa gggaagttcc agttggagct gttctcgtgc tcaataacag ggtgattggc      720

gagggttgga atagagccat tggactccat gatccaacag ctcacgcaga gattatggct      780

cttagacaag gcggcctcgt tatgcagaat tacagactca tcgacgccac actctacgtt      840

accttcgaac cttgcgttat gtgcgccgga gctatgatcc attctaggat tggcagggtc      900

gtgttcggcg ttagaaacgc taagacagga gctgcaggct ctcttatgga cgttcttcat      960

tacccaggca tgaatcatag agtggagatc acagaaggca ttcttgcaga cgagtgcgca     1020

gctctccttt gctatttctt caggatgccg aggcaagttt tcaacgctca gaagaaggcc     1080

cagtcttcta cagattccgg cggatcttct ggaggatcta gcggctccga gacaccagga     1140

acatccgaat ccgctacacc agagtcttct ggaggatcta gcggaggatc tcttaaggac     1200

aagaagtact cgatcggcct cgccattggg actaactctg ttggctgggc cgtgatcacc     1260

gacgagtaca aggtgccctc aaagaagttc aaggtcctgg gcaacaccga tcggcattcc     1320

atcaagaaga atctcattgg cgctctcctg ttcgacagcg gcgagacggc tgaggctacg     1380

cggctcaagc gcaccgcccg caggcggtac acgcgcagga agaatcgcat ctgctacctg     1440

caggagattt tctccaacga gatggcgaag gttgacgatt ctttcttcca caggctggag     1500

gagtcattcc tcgtggagga ggataagaag cacgagcggc atccaatctt cggcaacatt     1560

gtcgacgagg ttgcctacca cgagaagtac cctacgatct accatctgcg gaagaagctc     1620

gtggactcca cagataaggc ggacctccgc ctgatctacc tcgctctggc ccacatgatt     1680

aagttcaggg gccatttcct gatcgagggg gatctcaacc cggacaatag cgatgttgac     1740

aagctgttca tccagctcgt gcagacgtac aaccagctct tcgaggagaa ccccattaat     1800

gcgtcaggcg tcgacgcgaa ggctatcctg tccgctaggc tctcgaagtc tcggcgcctc     1860

gagaacctga tcgcccagct gccgggcgag aagaagaacg gcctgttcgg gaatctcatt     1920

gcgctcagcc tggggctcac gcccaacttc aagtcgaatt tcgatctcgc tgaggacgcc     1980

aagctgcagc tctccaagga cacatacgac gatgacctgg ataacctcct ggcccagatc     2040

ggcgatcagt acgcggacct gttcctcgct gccaagaatc tgtcggacgc catcctcctg     2100

tctgatattc tcagggtgaa caccgagatt acgaaggctc cgctctcagc ctccatgatc     2160

aagcgctacg acgagcacca tcaggatctg accctcctga aggcgctggt caggcagcag     2220

ctccccgaga agtacaagga gatcttcttc gatcagtcga agaacggcta cgctgggtac     2280

attgacggcg gggcctctca ggaggagttc tacaagttca tcaagccgat tctggagaag     2340

atggacggca cggaggagct gctggtgaag ctcaatcgcg aggacctcct gaggaagcag     2400

cggacattcg ataacggcag catcccacac cagattcatc tcggggagct gcacgctatc     2460

ctgaggaggc aggaggactt ctaccctttc ctcaaggata accgcgagaa gatcgagaag     2520

attctgactt tcaggatccc gtactacgtc ggcccactcg ctaggggcaa ctcccgcttc     2580

gcttggatga cccgcaagtc agaggagacg atcacgccgt ggaacttcga ggaggtggtc     2640

gacaagggcg ctagcgctca gtcgttcatc gagaggatga cgaatttcga caagaacctg     2700

ccaaatgaga aggtgctccc taagcactcg ctcctgtacg agtacttcac agtctacaac     2760

gagctgacta aggtgaagta tgtgaccgag ggcatgagga agccggcttt cctgtctggg     2820

gagcagaaga aggccatcgt ggacctcctg ttcaagacca accggaaggt cacggttaag     2880

cagctcaagg aggactactt caagaagatt gagtgcttcg attcggtcga gatctctggc     2940

gttgaggacc gcttcaacgc ctccctgggg acctaccacg atctcctgaa gatcattaag     3000

gataaggact tcctggacaa cgaggagaat gaggatatcc tcgaggacat tgtgctgaca     3060

ctcactctgt tcgaggaccg ggagatgatc gaggagcgcc tgaagactta cgcccatctc     3120

ttcgatgaca aggtcatgaa gcagctcaag aggaggaggt acaccggctg ggggaggctg     3180

agcaggaagc tcatcaacgg cattcgggac aagcagtccg ggaagacgat cctcgacttc     3240

ctgaagagcg atggcttcgc gaaccgcaat ttcatgcagc tgattcacga tgacagcctc     3300

acattcaagg aggatatcca gaaggctcag gtgagcggcc agggggactc gctgcacgag     3360

catatcgcga acctcgctgg ctcgccagct atcaagaagg ggattctgca gaccgtgaag     3420

gttgtggacg agctggtgaa ggtcatgggc aggcacaagc ctgagaacat cgtcattgag     3480

atggcccggg agaatcagac cacgcagaag ggccagaaga actcacgcga gaggatgaag     3540

aggatcgagg agggcattaa ggagctgggg tcccagatcc tcaaggagca cccggtggag     3600

aacacgcagc tgcagaatga gaagctctac ctgtactacc tccagaatgg ccgcgatatg     3660

tatgtggacc aggagctgga tattaacagg ctcagcgatt acgacgtcga tcatatcgtt     3720

ccacagtcat tcctgaagga tgactccatt gacaacaagg tcctcaccag gtcggacaag     3780

aaccggggca agtctgataa tgttccttca gaggaggtcg ttaagaagat gaagaactac     3840

tggcgccagc tcctgaatgc caagctgatc acgcagcgga agttcgataa cctcacaaag     3900

gctgagaggg gcgggctctc tgagctggac aaggcgggct tcatcaagag gcagctggtc     3960

gagacacggc agatcactaa gcacgttgcg cagattctcg actcacggat gaacactaag     4020

tacgatgaga atgacaagct gatccgcgag gtgaaggtca tcaccctgaa gtcaaagctc     4080

gtctccgact tcaggaagga tttccagttc tacaaggttc gggagatcaa caattaccac     4140

catgcccatg acgcgtacct gaacgcggtg gtcggcacag ctctgatcaa gaagtaccca     4200

aagctcgaga gcgagttcgt gtacggggac tacaaggttt acgatgtgag gaagatgatc     4260

gccaagtcgg agcaggagat tggcaaggct accgccaagt acttcttcta ctctaacatt     4320

atgaatttct tcaagacaga gatcactctg gccaatggcg agatccggaa gcgccccctc     4380

atcgagacga acggcgagac gggggagatc gtgtgggaca agggcaggga tttcgcgacc     4440

gtcaggaagg ttctctccat gccacaagtg aatatcgtca agaagacaga ggtccagact     4500

ggcgggttct ctaaggagtc aattctgcct aagcggaaca gcgacaagct catcgcccgc     4560

aagaaggact gggatccgaa gaagtacggc gggttcgaca gccccactgt ggcctactcg     4620

gtcctggttg tggcgaaggt tgagaagggc aagtccaaga agctcaagag cgtgaaggag     4680

ctgctgggga tcacgattat ggagcgctcc agcttcgaga agaacccgat cgatttcctg     4740

gaggcgaagg gctacaagga ggtgaagaag gacctgatca ttaagctccc caagtactca     4800

ctcttcgagc tggagaacgg caggaagcgg atgctggctt ccgctggcga gctgcagaag     4860

gggaacgagc tggctctgcc gtccaagtat gtgaacttcc tctacctggc ctcccactac     4920

gagaagctca agggcagccc cgaggacaac gagcagaagc agctgttcgt cgagcagcac     4980

aagcattacc tcgacgagat cattgagcag atttccgagt tctccaagcg cgtgatcctg     5040

gccgacgcga atctggataa ggtcctctcc gcgtacaaca agcaccgcga caagccaatc     5100

agggagcagg ctgagaatat cattcatctc ttcaccctga cgaacctcgg cgcccctgct     5160

gctttcaagt acttcgacac aactatcgat cgcaagaggt acacaagcac taaggaggtc     5220

ctggacgcga ccctcatcca ccagtcgatt accggcctct acgagacgcg catcgacctg     5280

tctcagctcg ggggcgactc cggcggcagc ccaaagaaga agcggaaggt gtag           5334


<210>  8
<211>  5686
<212>  DNA
<213>  artificial sequence

<220>
<223>  pJIT163-GFP

<400>  8
gagctcggta cctgacccgg tcgtgcccct ctctagagat aatgagcatt gcatgtctaa       60

gttataaaaa attaccacat attttttttg tcacacttgt ttgaagtgca gtttatctat      120

ctttatacat atatttaaac tttactctac gaataatata atctatagta ctacaataat      180

atcagtgttt tagagaatca tataaatgaa cagttagaca tggtctaaag gacaattgag      240

tattttgaca acaggactct acagttttat ctttttagtg tgcatgtgtt ctcctttttt      300

tttgcaaata gcttcaccta tataatactt catccatttt attagtacat ccatttaggg      360

tttagggtta atggttttta tagactaatt tttttagtac atctatttta ttctatttta      420

gcctctaaat taagaaaact aaaactctat tttagttttt ttatttaata atttagatat      480

aaaatagaat aaaataaagt gactaaaaat taaacaaata ccctttaaga aattaaaaaa      540

actaaggaaa catttttctt gtttcgagta gataatgcca gcctgttaaa cgccgtcgac      600

gagtctaacg gacaccaacc agcgaaccag cagcgtcgcg tcgggccaag cgaagcagac      660

ggcacggcat ctctgtcgct gcctctggac ccctctcgat cgagagttcc gctccaccgt      720

tggacttgct ccgctgtcgg catccagaaa ttgcgtggcg gagcggcaga cgtgagccgg      780

cacggcaggc ggcctcctcc tcctctcacg gcaccggcag ctacggggga ttcctttccc      840

accgctcctt cgctttccct tcctcgcccg ccgtaataaa tagacacccc ctccacaccc      900

tctttcccca acctcgtgtt gttcggagcg cacacacaca caaccagatc tcccccaaat      960

ccacccgtcg gcacctccgc ttcaaggtac gccgctcgtc ctcccccccc ccccctctct     1020

accttctcta gatcggcgtt ccggtccatg gttagggccc ggtagttcta cttctgttca     1080

tgtttgtgtt agatccgtgt ttgtgttaga tccgtgctgc tagcgttcgt acacggatgc     1140

gacctgtacg tcagacacgt tctgattgct aacttgccag tgtttctctt tggggaatcc     1200

tgggatggct ctagccgttc cgcagacggg atcgatttca tgattttttt tgtttcgttg     1260

catagggttt ggtttgccct tttcctttat ttcaatatat gccgtgcact tgtttgtcgg     1320

gtcatctttt catgcttttt tttgtcttgg ttgtgatgat gtggtctggt tgggcggtcg     1380

ttctagatcg gagtagaatt aattctgttt caaactacct ggtggattta ttaattttgg     1440

atctgtatgt gtgtgccata catattcata gttacgaatt gaagatgatg gatggaaata     1500

tcgatctagg ataggtatac atgttgatgc gggttttact gatgcatata cagagatgct     1560

ttttgttcgc ttggttgtga tgatgtggtg tggttgggcg gtcgttcatt cgttctagat     1620

cggagtagaa tactgtttca aactacctgg tgtatttatt aattttggaa ctgtatgtgt     1680

gtgtcataca tcttcatagt tacgagttta agatggatgg aaatatcgat ctaggatagg     1740

tatacatgtt gatgtgggtt ttactgatgc atatacatga tggcatatgc agcatctatt     1800

catatgctct aaccttgagt acctatctat tataataaac aagtatgttt tataattatt     1860

ttgatcttga tatacttgga tgatggcata tgcagcagct atatgtggat ttttttagcc     1920

ctgccttcat acgctattta tttgcttggt actgtttctt ttgtcgatgc tcaccctgtt     1980

gtttggtgtt acttctgcaa agcttgtcga cggatccatg gtgagcaagg gcgaggagct     2040

gttcaccggg gtggtgccca tcctggtcga gctggacggc gacgtaaacg gccacaagtt     2100

cagcgtgtcc ggcgagggcg agggcgatgc cacctacggc aagctgaccc tgaagttcat     2160

ctgcaccacc ggcaagctgc ccgtgccctg gcccaccctc gtgaccacct tcacctacgg     2220

cgtgcagtgc ttcagccgct accccgacca catgaagcag cacgacttct tcaagtccgc     2280

catgcccgaa ggctacgtcc aggagcgcac catcttcttc aaggacgacg gcaactacaa     2340

gacccgcgcc gaggtgaagt tcgagggcga caccctggtg aaccgcatcg agctgaaggg     2400

catcgacttc aaggaggacg gcaacatcct ggggcacaag ctggagtaca actacaacag     2460

ccacaacgtc tatatcatgg ccgacaagca gaagaacggc atcaaggtga acttcaagat     2520

ccgccacaac atcgaggacg gcagcgtgca gctcgccgac cactaccagc agaacacccc     2580

catcggcgac ggccccgtgc tgctgcccga caaccactac ctgagcaccc agtccgccct     2640

gagcaaagac cccaacgaga agcgcgatca catggtcctg ctggagttcg tgaccgccgc     2700

cgggatcact cacggcatgg acgagctgta caagtaaccc gggaattcgg tacgctgaaa     2760

tcaccagtct ctctctacaa atctatctct ctctattttc tccataaata atgtgtgagt     2820

agtttcccga taagggaaat tagggttctt atagggtttc gctcatgtgt tgagcatata     2880

agaaaccctt agtatgtatt tgtatttgta aaatacttct atcaataaaa tttctaattc     2940

ctaaaaccaa aatccagtac taaaatccag atctcctaaa gtccctatag atctttgtcg     3000

tgaatataaa ccagacacga gacgactaaa cctggagccc agacgccgtt cgaagctaga     3060

agtaccgctt aggcaggagg ccgttaggga aaagatgcta aggcagggtt ggttacgttg     3120

actcccccgt aggtttggtt taaatatgat gaagtggacg gaaggaagga ggaagacaag     3180

gaaggataag gttgcaggcc ctgtgcaagg taagaagatg gaaatttgat agaggtacgc     3240

tactatactt atactatacg ctaagggaat gcttgtattt ataccctata ccccctaata     3300

accccttatc aatttaagaa ataatccgca taagcccccg cttaaaaatt ggtatcagag     3360

ccatgaatag gtctatgacc aaaactcaag aggataaaac ctcaccaaaa tacgaaagag     3420

ttcttaactc taaagataaa agatctttca agatcaaaac tagttccctc acaccggagc     3480

atgcgatatc ctcgagagat ctaggcgtaa tcatggtcat agctgtttcc tgtgtgaaat     3540

tgttatccgc tcacaattcc acacaacata cgagccggaa gcataaagtg taaagcctgg     3600

ggtgcctaat gagtgagcta actcacatta attgcgttgc gctcactgcc cgctttccag     3660

tcgggaaacc tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt     3720

ttgcgtattg ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg     3780

ctgcggcgag cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg     3840

gataacgcag gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag     3900

gccgcgttgc tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga     3960

cgctcaagtc agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct     4020

ggaagctccc tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc     4080

tttctccctt cgggaagcgt ggcgctttct caatgctcac gctgtaggta tctcagttcg     4140

gtgtaggtcg ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc     4200

tgcgccttat ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca     4260

ctggcagcag ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag     4320

ttcttgaagt ggtggcctaa ctacggctac actagaagga cagtatttgg tatctgcgct     4380

ctgctgaagc cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc     4440

accgctggta gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga     4500

tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca     4560

cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat     4620

taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac     4680

caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt     4740

gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt     4800

gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag     4860

ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct     4920

attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt     4980

gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc     5040

tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt     5100

agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg     5160

gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg     5220

actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct     5280

tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc     5340

attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt     5400

tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt     5460

tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg     5520

aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta tcagggttat     5580

tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg     5640

cgcacatttc cccgaaaagt gccacctgcc agtgccaagc taattc                    5686


<210>  9
<211>  720
<212>  DNA
<213>  artificial sequence

<220>
<223>  pBUI-mGFP

<400>  9
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccttcaccta cggcgtgtag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actcacggca tggacgagct gtacaagtaa      720


<210>  10
<211>  5406
<212>  DNA
<213>  artificial sequence

<220>
<223>  SpnCas9-VQR-ABE

<400>  10
atgccaaaaa agaagagaaa ggtttcaggc ggctcctccg aggtggagtt ctctcacgag       60

tattggatga ggcacgctct tacacttgct aagagagctt gggacgaaag agaagtgcca      120

gttggcgccg ttcttgtgca taataatagg gtgatcggcg agggttggaa tagaccaatt      180

ggaaggcatg atccaacagc tcacgcagag attatggctc tcagacaagg cggcctcgtt      240

atgcagaact acaggctcat tgacgctaca ctctacgtga cactcgaacc ttgcgttatg      300

tgcgccggag ctatgattca ttctaggatt ggcagggtcg tgtttggagc tagggacgct      360

aaaacaggag ccgccggatc tcttatggac gtgttgcatc atccaggcat gaaccatagg      420

gtggagatta cagagggcat tcttgcagac gagtgcgctg ctcttctttc cgatttcttc      480

aggatgagaa ggcaggagat taaggcccag aagaaggctc agtcttctac agatagcgga      540

ggatcttccg gaggatctag cggctccgag acaccaggaa catccgaaag cgctacacca      600

gaatctagcg gaggctcttc cggaggatct tctgaagtgg agttctccca cgagtattgg      660

atgaggcacg ctcttacact tgctaaaagg gctagggacg aaagggaagt tccagttgga      720

gctgttctcg tgctcaataa cagggtgatt ggcgagggtt ggaatagagc cattggactc      780

catgatccaa cagctcacgc agagattatg gctcttagac aaggcggcct cgttatgcag      840

aattacagac tcatcgacgc cacactctac gttaccttcg aaccttgcgt tatgtgcgcc      900

ggagctatga tccattctag gattggcagg gtcgtgttcg gcgttagaaa cgctaagaca      960

ggagctgcag gctctcttat ggacgttctt cattacccag gcatgaatca tagagtggag     1020

atcacagaag gcattcttgc agacgagtgc gcagctctcc tttgctattt cttcaggatg     1080

ccgaggcaag ttttcaacgc tcagaagaag gcccagtctt ctacagattc cggcggatct     1140

tctggaggat ctagcggctc cgagacacca ggaacatccg aatccgctac accagagtct     1200

tctggaggat ctagcggagg atctcttaag ggcatccacg gggtgccagc tgctgacaag     1260

aagtactcga tcggcctcga tattgggact aactctgttg gctgggccgt gatcaccgac     1320

gagtacaagg tgccctcaaa gaagttcaag gtcctgggca acaccgatcg gcattccatc     1380

aagaagaatc tcattggcgc tctcctgttc gacagcggcg agacggctga ggctacgcgg     1440

ctcaagcgca ccgcccgcag gcggtacacg cgcaggaaga atcgcatctg ctacctgcag     1500

gagattttct ccaacgagat ggcgaaggtt gacgattctt tcttccacag gctggaggag     1560

tcattcctcg tggaggagga taagaagcac gagcggcatc caatcttcgg caacattgtc     1620

gacgaggttg cctaccacga gaagtaccct acgatctacc atctgcggaa gaagctcgtg     1680

gactccacag ataaggcgga cctccgcctg atctacctcg ctctggccca catgattaag     1740

ttcaggggcc atttcctgat cgagggggat ctcaacccgg acaatagcga tgttgacaag     1800

ctgttcatcc agctcgtgca gacgtacaac cagctcttcg aggagaaccc cattaatgcg     1860

tcaggcgtcg acgcgaaggc tatcctgtcc gctaggctct cgaagtctcg gcgcctcgag     1920

aacctgatcg cccagctgcc gggcgagaag aagaacggcc tgttcgggaa tctcattgcg     1980

ctcagcctgg ggctcacgcc caacttcaag tcgaatttcg atctcgctga ggacgccaag     2040

ctgcagctct ccaaggacac atacgacgat gacctggata acctcctggc ccagatcggc     2100

gatcagtacg cggacctgtt cctcgctgcc aagaatctgt cggacgccat cctcctgtct     2160

gatattctca gggtgaacac cgagattacg aaggctccgc tctcagcctc catgatcaag     2220

cgctacgacg agcaccatca ggatctgacc ctcctgaagg cgctggtcag gcagcagctc     2280

cccgagaagt acaaggagat cttcttcgat cagtcgaaga acggctacgc tgggtacatt     2340

gacggcgggg cctctcagga ggagttctac aagttcatca agccgattct ggagaagatg     2400

gacggcacgg aggagctgct ggtgaagctc aatcgcgagg acctcctgag gaagcagcgg     2460

acattcgata acggcagcat cccacaccag attcatctcg gggagctgca cgctatcctg     2520

aggaggcagg aggacttcta ccctttcctc aaggataacc gcgagaagat cgagaagatt     2580

ctgactttca ggatcccgta ctacgtcggc ccactcgcta ggggcaactc ccgcttcgct     2640

tggatgaccc gcaagtcaga ggagacgatc acgccgtgga acttcgagga ggtggtcgac     2700

aagggcgcta gcgctcagtc gttcatcgag aggatgacga atttcgacaa gaacctgcca     2760

aatgagaagg tgctccctaa gcactcgctc ctgtacgagt acttcacagt ctacaacgag     2820

ctgactaagg tgaagtatgt gaccgagggc atgaggaagc cggctttcct gtctggggag     2880

cagaagaagg ccatcgtgga cctcctgttc aagaccaacc ggaaggtcac ggttaagcag     2940

ctcaaggagg actacttcaa gaagattgag tgcttcgatt cggtcgagat ctctggcgtt     3000

gaggaccgct tcaacgcctc cctggggacc taccacgatc tcctgaagat cattaaggat     3060

aaggacttcc tggacaacga ggagaatgag gatatcctcg aggacattgt gctgacactc     3120

actctgttcg aggaccggga gatgatcgag gagcgcctga agacttacgc ccatctcttc     3180

gatgacaagg tcatgaagca gctcaagagg aggaggtaca ccggctgggg gaggctgagc     3240

aggaagctca tcaacggcat tcgggacaag cagtccggga agacgatcct cgacttcctg     3300

aagagcgatg gcttcgcgaa ccgcaatttc atgcagctga ttcacgatga cagcctcaca     3360

ttcaaggagg atatccagaa ggctcaggtg agcggccagg gggactcgct gcacgagcat     3420

atcgcgaacc tcgctggctc gccagctatc aagaagggga ttctgcagac cgtgaaggtt     3480

gtggacgagc tggtgaaggt catgggcagg cacaagcctg agaacatcgt cattgagatg     3540

gcccgggaga atcagaccac gcagaagggc cagaagaact cacgcgagag gatgaagagg     3600

atcgaggagg gcattaagga gctggggtcc cagatcctca aggagcaccc ggtggagaac     3660

acgcagctgc agaatgagaa gctctacctg tactacctcc agaatggccg cgatatgtat     3720

gtggaccagg agctggatat taacaggctc agcgattacg acgtcgatca tatcgttcca     3780

cagtcattcc tgaaggatga ctccattgac aacaaggtcc tcaccaggtc ggacaagaac     3840

cggggcaagt ctgataatgt tccttcagag gaggtcgtta agaagatgaa gaactactgg     3900

cgccagctcc tgaatgccaa gctgatcacg cagcggaagt tcgataacct cacaaaggct     3960

gagaggggcg ggctctctga gctggacaag gcgggcttca tcaagaggca gctggtcgag     4020

acacggcaga tcactaagca cgttgcgcag attctcgact cacggatgaa cactaagtac     4080

gatgagaatg acaagctgat ccgcgaggtg aaggtcatca ccctgaagtc aaagctcgtc     4140

tccgacttca ggaaggattt ccagttctac aaggttcggg agatcaacaa ttaccaccat     4200

gcccatgacg cgtacctgaa cgcggtggtc ggcacagctc tgatcaagaa gtacccaaag     4260

ctcgagagcg agttcgtgta cggggactac aaggtttacg atgtgaggaa gatgatcgcc     4320

aagtcggagc aggagattgg caaggctacc gccaagtact tcttctactc taacattatg     4380

aatttcttca agacagagat cactctggcc aatggcgaga tccggaagcg ccccctcatc     4440

gagacgaacg gcgagacggg ggagatcgtg tgggacaagg gcagggattt cgcgaccgtc     4500

aggaaggttc tctccatgcc acaagtgaat atcgtcaaga agacagaggt ccagactggc     4560

gggttctcta aggagtcaat tctgcctaag cggaacagcg acaagctcat cgcccgcaag     4620

aaggactggg atccgaagaa gtacggcggg ttcgtcagcc ccactgtggc ctactcggtc     4680

ctggttgtgg cgaaggttga gaagggcaag tccaagaagc tcaagagcgt gaaggagctg     4740

ctggggatca cgattatgga gcgctccagc ttcgagaaga acccgatcga tttcctggag     4800

gcgaagggct acaaggaggt gaagaaggac ctgatcatta agctccccaa gtactcactc     4860

ttcgagctgg agaacggcag gaagcggatg ctggcttccg ctggcgagct gcagaagggg     4920

aacgagctgg ctctgccgtc caagtatgtg aacttcctct acctggcctc ccactacgag     4980

aagctcaagg gcagccccga ggacaacgag cagaagcagc tgttcgtcga gcagcacaag     5040

cattacctcg acgagatcat tgagcagatt tccgagttct ccaagcgcgt gatcctggcc     5100

gacgcgaatc tggataaggt cctctccgcg tacaacaagc accgcgacaa gccaatcagg     5160

gagcaggctg agaatatcat tcatctcttc accctgacga acctcggcgc ccctgctgct     5220

ttcaagtact tcgacacaac tatcgatcgc aagcagtaca gaagcactaa ggaggtcctg     5280

gacgcgaccc tcatccacca gtcgattacc ggcctctacg agacgcgcat cgacctgtct     5340

cagctcgggg gcgacaagcg gccagcggcg acgaagaagg cggggcaggc gaagaagaag     5400

aagtag                                                                5406


<210>  11
<211>  5406
<212>  DNA
<213>  artificial sequence

<220>
<223>  SpnCas9-VRER-ABE

<400>  11
atgccaaaaa agaagagaaa ggtttcaggc ggctcctccg aggtggagtt ctctcacgag       60

tattggatga ggcacgctct tacacttgct aagagagctt gggacgaaag agaagtgcca      120

gttggcgccg ttcttgtgca taataatagg gtgatcggcg agggttggaa tagaccaatt      180

ggaaggcatg atccaacagc tcacgcagag attatggctc tcagacaagg cggcctcgtt      240

atgcagaact acaggctcat tgacgctaca ctctacgtga cactcgaacc ttgcgttatg      300

tgcgccggag ctatgattca ttctaggatt ggcagggtcg tgtttggagc tagggacgct      360

aaaacaggag ccgccggatc tcttatggac gtgttgcatc atccaggcat gaaccatagg      420

gtggagatta cagagggcat tcttgcagac gagtgcgctg ctcttctttc cgatttcttc      480

aggatgagaa ggcaggagat taaggcccag aagaaggctc agtcttctac agatagcgga      540

ggatcttccg gaggatctag cggctccgag acaccaggaa catccgaaag cgctacacca      600

gaatctagcg gaggctcttc cggaggatct tctgaagtgg agttctccca cgagtattgg      660

atgaggcacg ctcttacact tgctaaaagg gctagggacg aaagggaagt tccagttgga      720

gctgttctcg tgctcaataa cagggtgatt ggcgagggtt ggaatagagc cattggactc      780

catgatccaa cagctcacgc agagattatg gctcttagac aaggcggcct cgttatgcag      840

aattacagac tcatcgacgc cacactctac gttaccttcg aaccttgcgt tatgtgcgcc      900

ggagctatga tccattctag gattggcagg gtcgtgttcg gcgttagaaa cgctaagaca      960

ggagctgcag gctctcttat ggacgttctt cattacccag gcatgaatca tagagtggag     1020

atcacagaag gcattcttgc agacgagtgc gcagctctcc tttgctattt cttcaggatg     1080

ccgaggcaag ttttcaacgc tcagaagaag gcccagtctt ctacagattc cggcggatct     1140

tctggaggat ctagcggctc cgagacacca ggaacatccg aatccgctac accagagtct     1200

tctggaggat ctagcggagg atctcttaag ggcatccacg gggtgccagc tgctgacaag     1260

aagtactcga tcggcctcga tattgggact aactctgttg gctgggccgt gatcaccgac     1320

gagtacaagg tgccctcaaa gaagttcaag gtcctgggca acaccgatcg gcattccatc     1380

aagaagaatc tcattggcgc tctcctgttc gacagcggcg agacggctga ggctacgcgg     1440

ctcaagcgca ccgcccgcag gcggtacacg cgcaggaaga atcgcatctg ctacctgcag     1500

gagattttct ccaacgagat ggcgaaggtt gacgattctt tcttccacag gctggaggag     1560

tcattcctcg tggaggagga taagaagcac gagcggcatc caatcttcgg caacattgtc     1620

gacgaggttg cctaccacga gaagtaccct acgatctacc atctgcggaa gaagctcgtg     1680

gactccacag ataaggcgga cctccgcctg atctacctcg ctctggccca catgattaag     1740

ttcaggggcc atttcctgat cgagggggat ctcaacccgg acaatagcga tgttgacaag     1800

ctgttcatcc agctcgtgca gacgtacaac cagctcttcg aggagaaccc cattaatgcg     1860

tcaggcgtcg acgcgaaggc tatcctgtcc gctaggctct cgaagtctcg gcgcctcgag     1920

aacctgatcg cccagctgcc gggcgagaag aagaacggcc tgttcgggaa tctcattgcg     1980

ctcagcctgg ggctcacgcc caacttcaag tcgaatttcg atctcgctga ggacgccaag     2040

ctgcagctct ccaaggacac atacgacgat gacctggata acctcctggc ccagatcggc     2100

gatcagtacg cggacctgtt cctcgctgcc aagaatctgt cggacgccat cctcctgtct     2160

gatattctca gggtgaacac cgagattacg aaggctccgc tctcagcctc catgatcaag     2220

cgctacgacg agcaccatca ggatctgacc ctcctgaagg cgctggtcag gcagcagctc     2280

cccgagaagt acaaggagat cttcttcgat cagtcgaaga acggctacgc tgggtacatt     2340

gacggcgggg cctctcagga ggagttctac aagttcatca agccgattct ggagaagatg     2400

gacggcacgg aggagctgct ggtgaagctc aatcgcgagg acctcctgag gaagcagcgg     2460

acattcgata acggcagcat cccacaccag attcatctcg gggagctgca cgctatcctg     2520

aggaggcagg aggacttcta ccctttcctc aaggataacc gcgagaagat cgagaagatt     2580

ctgactttca ggatcccgta ctacgtcggc ccactcgcta ggggcaactc ccgcttcgct     2640

tggatgaccc gcaagtcaga ggagacgatc acgccgtgga acttcgagga ggtggtcgac     2700

aagggcgcta gcgctcagtc gttcatcgag aggatgacga atttcgacaa gaacctgcca     2760

aatgagaagg tgctccctaa gcactcgctc ctgtacgagt acttcacagt ctacaacgag     2820

ctgactaagg tgaagtatgt gaccgagggc atgaggaagc cggctttcct gtctggggag     2880

cagaagaagg ccatcgtgga cctcctgttc aagaccaacc ggaaggtcac ggttaagcag     2940

ctcaaggagg actacttcaa gaagattgag tgcttcgatt cggtcgagat ctctggcgtt     3000

gaggaccgct tcaacgcctc cctggggacc taccacgatc tcctgaagat cattaaggat     3060

aaggacttcc tggacaacga ggagaatgag gatatcctcg aggacattgt gctgacactc     3120

actctgttcg aggaccggga gatgatcgag gagcgcctga agacttacgc ccatctcttc     3180

gatgacaagg tcatgaagca gctcaagagg aggaggtaca ccggctgggg gaggctgagc     3240

aggaagctca tcaacggcat tcgggacaag cagtccggga agacgatcct cgacttcctg     3300

aagagcgatg gcttcgcgaa ccgcaatttc atgcagctga ttcacgatga cagcctcaca     3360

ttcaaggagg atatccagaa ggctcaggtg agcggccagg gggactcgct gcacgagcat     3420

atcgcgaacc tcgctggctc gccagctatc aagaagggga ttctgcagac cgtgaaggtt     3480

gtggacgagc tggtgaaggt catgggcagg cacaagcctg agaacatcgt cattgagatg     3540

gcccgggaga atcagaccac gcagaagggc cagaagaact cacgcgagag gatgaagagg     3600

atcgaggagg gcattaagga gctggggtcc cagatcctca aggagcaccc ggtggagaac     3660

acgcagctgc agaatgagaa gctctacctg tactacctcc agaatggccg cgatatgtat     3720

gtggaccagg agctggatat taacaggctc agcgattacg acgtcgatca tatcgttcca     3780

cagtcattcc tgaaggatga ctccattgac aacaaggtcc tcaccaggtc ggacaagaac     3840

cggggcaagt ctgataatgt tccttcagag gaggtcgtta agaagatgaa gaactactgg     3900

cgccagctcc tgaatgccaa gctgatcacg cagcggaagt tcgataacct cacaaaggct     3960

gagaggggcg ggctctctga gctggacaag gcgggcttca tcaagaggca gctggtcgag     4020

acacggcaga tcactaagca cgttgcgcag attctcgact cacggatgaa cactaagtac     4080

gatgagaatg acaagctgat ccgcgaggtg aaggtcatca ccctgaagtc aaagctcgtc     4140

tccgacttca ggaaggattt ccagttctac aaggttcggg agatcaacaa ttaccaccat     4200

gcccatgacg cgtacctgaa cgcggtggtc ggcacagctc tgatcaagaa gtacccaaag     4260

ctcgagagcg agttcgtgta cggggactac aaggtttacg atgtgaggaa gatgatcgcc     4320

aagtcggagc aggagattgg caaggctacc gccaagtact tcttctactc taacattatg     4380

aatttcttca agacagagat cactctggcc aatggcgaga tccggaagcg ccccctcatc     4440

gagacgaacg gcgagacggg ggagatcgtg tgggacaagg gcagggattt cgcgaccgtc     4500

aggaaggttc tctccatgcc acaagtgaat atcgtcaaga agacagaggt ccagactggc     4560

gggttctcta aggagtcaat tctgcctaag cggaacagcg acaagctcat cgcccgcaag     4620

aaggactggg atccgaagaa gtacggcggg ttcgtcagcc ccactgtggc ctactcggtc     4680

ctggttgtgg cgaaggttga gaagggcaag tccaagaagc tcaagagcgt gaaggagctg     4740

ctggggatca cgattatgga gcgctccagc ttcgagaaga acccgatcga tttcctggag     4800

gcgaagggct acaaggaggt gaagaaggac ctgatcatta agctccccaa gtactcactc     4860

ttcgagctgg agaacggcag gaagcggatg ctggcttccg ctcgcgagct gcagaagggg     4920

aacgagctgg ctctgccgtc caagtatgtg aacttcctct acctggcctc ccactacgag     4980

aagctcaagg gcagccccga ggacaacgag cagaagcagc tgttcgtcga gcagcacaag     5040

cattacctcg acgagatcat tgagcagatt tccgagttct ccaagcgcgt gatcctggcc     5100

gacgcgaatc tggataaggt cctctccgcg tacaacaagc accgcgacaa gccaatcagg     5160

gagcaggctg agaatatcat tcatctcttc accctgacga acctcggcgc ccctgctgct     5220

ttcaagtact tcgacacaac tatcgatcgc aaggagtaca gaagcactaa ggaggtcctg     5280

gacgcgaccc tcatccacca gtcgattacc ggcctctacg agacgcgcat cgacctgtct     5340

cagctcgggg gcgacaagcg gccagcggcg acgaagaagg cggggcaggc gaagaagaag     5400

aagtag                                                                5406


<210>  12
<211>  4437
<212>  DNA
<213>  artificial sequence

<220>
<223>  SanCas9-ABE

<400>  12
atgccaaaaa agaagagaaa ggtttcaggc ggctcctccg aggtggagtt ctctcacgag       60

tattggatga ggcacgctct tacacttgct aagagagctt gggacgaaag agaagtgcca      120

gttggcgccg ttcttgtgca taataatagg gtgatcggcg agggttggaa tagaccaatt      180

ggaaggcatg atccaacagc tcacgcagag attatggctc tcagacaagg cggcctcgtt      240

atgcagaact acaggctcat tgacgctaca ctctacgtga cactcgaacc ttgcgttatg      300

tgcgccggag ctatgattca ttctaggatt ggcagggtcg tgtttggagc tagggacgct      360

aaaacaggag ccgccggatc tcttatggac gtgttgcatc atccaggcat gaaccatagg      420

gtggagatta cagagggcat tcttgcagac gagtgcgctg ctcttctttc cgatttcttc      480

aggatgagaa ggcaggagat taaggcccag aagaaggctc agtcttctac agatagcgga      540

ggatcttccg gaggatctag cggctccgag acaccaggaa catccgaaag cgctacacca      600

gaatctagcg gaggctcttc cggaggatct tctgaagtgg agttctccca cgagtattgg      660

atgaggcacg ctcttacact tgctaaaagg gctagggacg aaagggaagt tccagttgga      720

gctgttctcg tgctcaataa cagggtgatt ggcgagggtt ggaatagagc cattggactc      780

catgatccaa cagctcacgc agagattatg gctcttagac aaggcggcct cgttatgcag      840

aattacagac tcatcgacgc cacactctac gttaccttcg aaccttgcgt tatgtgcgcc      900

ggagctatga tccattctag gattggcagg gtcgtgttcg gcgttagaaa cgctaagaca      960

ggagctgcag gctctcttat ggacgttctt cattacccag gcatgaatca tagagtggag     1020

atcacagaag gcattcttgc agacgagtgc gcagctctcc tttgctattt cttcaggatg     1080

ccgaggcaag ttttcaacgc tcagaagaag gcccagtctt ctacagattc cggcggatct     1140

tctggaggat ctagcggctc cgagacacca ggaacatccg aatccgctac accagagtct     1200

tctggaggat ctagcggagg atctcttaag aagaggaact acatcctcgg gctggatatt     1260

ggcatcacct ctgtgggcta cgggatcatt gactacgaga cgcgggatgt catcgacgct     1320

ggcgttcgcc tgttcaagga ggccaacgtc gagaacaatg aggggaggag gtccaagagg     1380

ggcgcccgca ggctcaagag gaggaggagg cacaggatcc agagggtgaa gaagctcctg     1440

ttcgattaca acctcctgac cgaccattcg gagctgtctg ggatcaatcc gtacgaggcc     1500

cgcgtcaagg gcctgtctca gaagctctca gaggaggagt tcagcgctgc cctcctgcac     1560

ctcgctaagc gcaggggcgt ccataacgtt aatgaggtgg aggaggacac aggcaacgag     1620

ctgtcgacta aggagcagat ctcccgcaac tccaaggcgc tggaggagaa gtatgtggct     1680

gagctgcagc tggagcgcct caagaaggat ggggaggtcc ggggctcaat caaccgcttc     1740

aagacatccg actacgtcaa ggaggccaag cagctcctga aggttcagaa ggcgtaccac     1800

cagctggacc agtcattcat tgatacttac atcgacctcc tcgagacgag gcggacgtac     1860

tacgagggcc caggggaggg ctcccccttc gggtggaagg acatcaagga gtggtacgag     1920

atgctgatgg gccattgcac gtacttcccg gaggagctga ggagcgttaa gtacgcttac     1980

aacgccgatc tgtacaacgc gctcaatgac ctgaacaatc tcgtcatcac ccgggacgag     2040

aacgagaagc tcgagtacta cgagaagttc cagatcattg agaatgtgtt caagcagaag     2100

aagaagccaa cgctgaagca gattgcgaag gagatcctcg ttaacgagga ggacatcaag     2160

gggtacaggg tgacctcgac gggcaagcct gagttcacaa acctgaaggt ctaccacgat     2220

attaaggaca tcactgccag gaaggagatc attgagaacg ccgagctgct cgaccagatt     2280

gcgaagatcc tcacgatcta ccagtccagc gaggacatcc aggaggagct gaccaacctc     2340

aattcggagc tgacgcagga ggagatcgag cagatttcta acctgaaggg gtacacaggc     2400

actcacaacc tcagcctgaa ggcgatcaat ctcattctgg atgagctgtg gcatacaaac     2460

gacaatcaga ttgctatctt caacaggctc aagctggtgc caaagaaggt cgacctctct     2520

cagcagaagg agatcccgac cacgctggtg gacgatttca ttctctcacc cgtggtcaag     2580

aggtccttca tccagagcat taaggtcatc aacgccatca ttaagaagta cggcctgccc     2640

aatgatatca ttatcgagct ggcgcgcgag aagaactcca aggacgctca gaagatgatc     2700

aatgagatgc agaagcggaa ccgccagacc aatgagagga tcgaggagat tatccggaca     2760

actggcaagg agaacgctaa gtacctgatt gagaagatca agctccacga tatgcaggag     2820

ggcaagtgcc tgtactccct cgaggccatc ccactggagg acctcctgaa caatcctttc     2880

aactacgagg ttgatcatat tatcccgagg tccgtgagct tcgacaatag cttcaacaat     2940

aaggtcctgg ttaagcaaga ggagaactcg aagaagggca atcgcacccc cttccagtac     3000

ctctcgtctt cagacagcaa gatctcgtac gagacgttca agaagcacat tctcaacctg     3060

gcgaagggga agggcaggat ctccaagacc aagaaggagt acctcctgga ggagcgggac     3120

atcaaccgct tcagcgtcca gaaggatttc attaaccgga atctggttga cacacgctac     3180

gccactcggg gcctcatgaa cctcctgcgc tcctacttca gggtgaacaa tctggacgtg     3240

aaggtcaaga gcatcaacgg cgggttcacg tcgttcctcc gcaggaagtg gaagttcaag     3300

aaggagagga acaagggcta caagcaccat gcggaggatg ctctgattat cgccaatgcg     3360

gacttcatct tcaaggagtg gaagaagctc gacaaggcca agaaggtcat ggagaaccag     3420

atgttcgagg agaagcaggc cgagagcatg ccagagatcg agacagagca ggagtacaag     3480

gagattttca tcactcctca ccagattaag catatcaagg atttcaagga ctacaagtac     3540

tcgcaccgcg tggataagaa gccgaacagg gagctgatca atgacaccct ctactctacg     3600

cgcaaggacg ataaggggaa cacactcatc gtcaacaatc tgaacggcct ctacgacaag     3660

gataatgaca agctgaagaa gctcatcaac aagagcccag agaagctcct gatgtaccac     3720

catgatcctc agacttacca gaagctcaag ctgatcatgg agcagtacgg cgacgagaag     3780

aacccgctct acaagtacta cgaggagaca ggcaactacc tgactaagta ctcgaagaag     3840

gataatgggc ccgtgattaa gaagatcaag tactacggca acaagctgaa tgcgcatctc     3900

gacatcaccg acgattaccc gaactctcgc aataaggttg tgaagctctc actgaagccc     3960

tacaggttcg atgtgtacct ggacaacggc gtctacaagt tcgttacggt gaagaatctc     4020

gacgtgatca agaaggagaa ctactacgag gtcaattcca agtgctacga ggaggccaag     4080

aagctgaaga agatttccaa ccaggctgag ttcatcgcca gcttctacaa caatgacctg     4140

attaagatca acggggagct gtacagggtc atcggcgtta acaatgatct cctgaaccgg     4200

attgaagtga atatgattga catcacctac cgcgagtacc tcgagaacat gaatgataag     4260

cgcccgccca ggattatcaa gaccattgcc tcgaagacgc agtctatcaa gaagtactca     4320

acagacattc tgggcaacct ctacgaggtc aagtccaaga agcacccgca gattatcaag     4380

aagggcaagc gcccggccgc cactaagaag gctgggcagg ccaagaagaa gaagtag        4437


<210>  13
<211>  4431
<212>  DNA
<213>  artificial sequence

<220>
<223>  SanCas9-KKH-ABE

<400>  13
atgccaaaaa agaagagaaa ggtttcaggc ggctcctccg aggtggagtt ctctcacgag       60

tattggatga ggcacgctct tacacttgct aagagagctt gggacgaaag agaagtgcca      120

gttggcgccg ttcttgtgca taataatagg gtgatcggcg agggttggaa tagaccaatt      180

ggaaggcatg atccaacagc tcacgcagag attatggctc tcagacaagg cggcctcgtt      240

atgcagaact acaggctcat tgacgctaca ctctacgtga cactcgaacc ttgcgttatg      300

tgcgccggag ctatgattca ttctaggatt ggcagggtcg tgtttggagc tagggacgct      360

aaaacaggag ccgccggatc tcttatggac gtgttgcatc atccaggcat gaaccatagg      420

gtggagatta cagagggcat tcttgcagac gagtgcgctg ctcttctttc cgatttcttc      480

aggatgagaa ggcaggagat taaggcccag aagaaggctc agtcttctac agatagcgga      540

ggatcttccg gaggatctag cggctccgag acaccaggaa catccgaaag cgctacacca      600

gaatctagcg gaggctcttc cggaggatct tctgaagtgg agttctccca cgagtattgg      660

atgaggcacg ctcttacact tgctaaaagg gctagggacg aaagggaagt tccagttgga      720

gctgttctcg tgctcaataa cagggtgatt ggcgagggtt ggaatagagc cattggactc      780

catgatccaa cagctcacgc agagattatg gctcttagac aaggcggcct cgttatgcag      840

aattacagac tcatcgacgc cacactctac gttaccttcg aaccttgcgt tatgtgcgcc      900

ggagctatga tccattctag gattggcagg gtcgtgttcg gcgttagaaa cgctaagaca      960

ggagctgcag gctctcttat ggacgttctt cattacccag gcatgaatca tagagtggag     1020

atcacagaag gcattcttgc agacgagtgc gcagctctcc tttgctattt cttcaggatg     1080

ccgaggcaag ttttcaacgc tcagaagaag gcccagtctt ctacagattc cggcggatct     1140

tctggaggat ctagcggctc cgagacacca ggaacatccg aatccgctac accagagtct     1200

tctggaggat ctagcggagg atctaagagg aactacatcc tcgggctgga tattggcatc     1260

acctctgtgg gctacgggat cattgactac gagacgcggg atgtcatcga cgctggcgtt     1320

cgcctgttca aggaggccaa cgtcgagaac aatgagggga ggaggtccaa gaggggcgcc     1380

cgcaggctca agaggaggag gaggcacagg atccagaggg tgaagaagct cctgttcgat     1440

tacaacctcc tgaccgacca ttcggagctg tctgggatca atccgtacga ggcccgcgtc     1500

aagggcctgt ctcagaagct ctcagaggag gagttcagcg ctgccctcct gcacctcgct     1560

aagcgcaggg gcgtccataa cgttaatgag gtggaggagg acacaggcaa cgagctgtcg     1620

actaaggagc agatctcccg caactccaag gcgctggagg agaagtatgt ggctgagctg     1680

cagctggagc gcctcaagaa ggatggggag gtccggggct caatcaaccg cttcaagaca     1740

tccgactacg tcaaggaggc caagcagctc ctgaaggttc agaaggcgta ccaccagctg     1800

gaccagtcat tcattgatac ttacatcgac ctcctcgaga cgaggcggac gtactacgag     1860

ggcccagggg agggctcccc cttcgggtgg aaggacatca aggagtggta cgagatgctg     1920

atgggccatt gcacgtactt cccggaggag ctgaggagcg ttaagtacgc ttacaacgcc     1980

gatctgtaca acgcgctcaa tgacctgaac aatctcgtca tcacccggga cgagaacgag     2040

aagctcgagt actacgagaa gttccagatc attgagaatg tgttcaagca gaagaagaag     2100

ccaacgctga agcagattgc gaaggagatc ctcgttaacg aggaggacat caaggggtac     2160

agggtgacct cgacgggcaa gcctgagttc acaaacctga aggtctacca cgatattaag     2220

gacatcactg ccaggaagga gatcattgag aacgccgagc tgctcgacca gattgcgaag     2280

atcctcacga tctaccagtc cagcgaggac atccaggagg agctgaccaa cctcaattcg     2340

gagctgacgc aggaggagat cgagcagatt tctaacctga aggggtacac aggcactcac     2400

aacctcagcc tgaaggcgat caatctcatt ctggatgagc tgtggcatac aaacgacaat     2460

cagattgcta tcttcaacag gctcaagctg gtgccaaaga aggtcgacct ctctcagcag     2520

aaggagatcc cgaccacgct ggtggacgat ttcattctct cacccgtggt caagaggtcc     2580

ttcatccaga gcattaaggt catcaacgcc atcattaaga agtacggcct gcccaatgat     2640

atcattatcg agctggcgcg cgagaagaac tccaaggacg ctcagaagat gatcaatgag     2700

atgcagaagc ggaaccgcca gaccaatgag aggatcgagg agattatccg gacaactggc     2760

aaggagaacg ctaagtacct gattgagaag atcaagctcc acgatatgca ggagggcaag     2820

tgcctgtact ccctcgaggc catcccactg gaggacctcc tgaacaatcc tttcaactac     2880

gaggttgatc atattatccc gaggtccgtg agcttcgaca atagcttcaa caataaggtc     2940

ctggttaagc aagaggagaa ctcgaagaag ggcaatcgca cccccttcca gtacctctcg     3000

tcttcagaca gcaagatctc gtacgagacg ttcaagaagc acattctcaa cctggcgaag     3060

gggaagggca ggatctccaa gaccaagaag gagtacctcc tggaggagcg ggacatcaac     3120

cgcttcagcg tccagaagga tttcattaac cggaatctgg ttgacacacg ctacgccact     3180

cggggcctca tgaacctcct gcgctcctac ttcagggtga acaatctgga cgtgaaggtc     3240

aagagcatca acggcgggtt cacgtcgttc ctccgcagga agtggaagtt caagaaggag     3300

aggaacaagg gctacaagca ccatgcggag gatgctctga ttatcgccaa tgcggacttc     3360

atcttcaagg agtggaagaa gctcgacaag gccaagaagg tcatggagaa ccagatgttc     3420

gaggagaagc aggccgagag catgccagag atcgagacag agcaggagta caaggagatt     3480

ttcatcactc ctcaccagat taagcatatc aaggatttca aggactacaa gtactcgcac     3540

cgcgtggata agaagccgaa caggaagctg atcaatgaca ccctctactc tacgcgcaag     3600

gacgataagg ggaacacact catcgtcaac aatctgaacg gcctctacga caaggataat     3660

gacaagctga agaagctcat caacaagagc ccagagaagc tcctgatgta ccaccatgat     3720

cctcagactt accagaagct caagctgatc atggagcagt acggcgacga gaagaacccg     3780

ctctacaagt actacgagga gacaggcaac tacctgacta agtactcgaa gaaggataat     3840

gggcccgtga ttaagaagat caagtactac ggcaacaagc tgaatgcgca tctcgacatc     3900

accgacgatt acccgaactc tcgcaataag gttgtgaagc tctcactgaa gccctacagg     3960

ttcgatgtgt acctggacaa cggcgtctac aagttcgtta cggtgaagaa tctcgacgtg     4020

atcaagaagg agaactacta cgaggtcaat tccaagtgct acgaggaggc caagaagctg     4080

aagaagattt ccaaccaggc tgagttcatc gccagcttct acaagaatga cctgattaag     4140

atcaacgggg agctgtacag ggtcatcggc gttaacaatg atctcctgaa ccggattgaa     4200

gtgaatatga ttgacatcac ctaccgcgag tacctcgaga acatgaatga taagcgcccg     4260

ccccacatta tcaagaccat tgcctcgaag acgcagtcta tcaagaagta ctcaacagac     4320

attctgggca acctctacga ggtcaagtcc aagaagcacc cgcagattat caagaagggc     4380

aagcgcccgg ccgccactaa gaaggctggg caggccaaga agaagaagta g              4431


<210>  14
<211>  5373
<212>  DNA
<213>  artificial sequence

<220>
<223>  SpnCas9-VQR-ABE-1

<400>  14
atgtccgagg tggagttctc tcacgagtat tggatgaggc acgctcttac acttgctaag       60

agagcttggg acgaaagaga agtgccagtt ggcgccgttc ttgtgcataa taatagggtg      120

atcggcgagg gttggaatag accaattgga aggcatgatc caacagctca cgcagagatt      180

atggctctca gacaaggcgg cctcgttatg cagaactaca ggctcattga cgctacactc      240

tacgtgacac tcgaaccttg cgttatgtgc gccggagcta tgattcattc taggattggc      300

agggtcgtgt ttggagctag ggacgctaaa acaggagccg ccggatctct tatggacgtg      360

ttgcatcatc caggcatgaa ccatagggtg gagattacag agggcattct tgcagacgag      420

tgcgctgctc ttctttccga tttcttcagg atgagaaggc aggagattaa ggcccagaag      480

aaggctcagt cttctacaga tagcggagga tcttccggag gatctagcgg ctccgagaca      540

ccaggaacat ccgaaagcgc tacaccagaa tctagcggag gctcttccgg aggatcttct      600

gaagtggagt tctcccacga gtattggatg aggcacgctc ttacacttgc taaaagggct      660

agggacgaaa gggaagttcc agttggagct gttctcgtgc tcaataacag ggtgattggc      720

gagggttgga atagagccat tggactccat gatccaacag ctcacgcaga gattatggct      780

cttagacaag gcggcctcgt tatgcagaat tacagactca tcgacgccac actctacgtt      840

accttcgaac cttgcgttat gtgcgccgga gctatgatcc attctaggat tggcagggtc      900

gtgttcggcg ttagaaacgc taagacagga gctgcaggct ctcttatgga cgttcttcat      960

tacccaggca tgaatcatag agtggagatc acagaaggca ttcttgcaga cgagtgcgca     1020

gctctccttt gctatttctt caggatgccg aggcaagttt tcaacgctca gaagaaggcc     1080

cagtcttcta cagattccgg cggatcttct ggaggatcta gcggctccga gacaccagga     1140

acatccgaat ccgctacacc agagtcttct ggaggatcta gcggaggatc tcttaagggc     1200

atccacgggg tgccagctgc tgacaagaag tactcgatcg gcctcgatat tgggactaac     1260

tctgttggct gggccgtgat caccgacgag tacaaggtgc cctcaaagaa gttcaaggtc     1320

ctgggcaaca ccgatcggca ttccatcaag aagaatctca ttggcgctct cctgttcgac     1380

agcggcgaga cggctgaggc tacgcggctc aagcgcaccg cccgcaggcg gtacacgcgc     1440

aggaagaatc gcatctgcta cctgcaggag attttctcca acgagatggc gaaggttgac     1500

gattctttct tccacaggct ggaggagtca ttcctcgtgg aggaggataa gaagcacgag     1560

cggcatccaa tcttcggcaa cattgtcgac gaggttgcct accacgagaa gtaccctacg     1620

atctaccatc tgcggaagaa gctcgtggac tccacagata aggcggacct ccgcctgatc     1680

tacctcgctc tggcccacat gattaagttc aggggccatt tcctgatcga gggggatctc     1740

aacccggaca atagcgatgt tgacaagctg ttcatccagc tcgtgcagac gtacaaccag     1800

ctcttcgagg agaaccccat taatgcgtca ggcgtcgacg cgaaggctat cctgtccgct     1860

aggctctcga agtctcggcg cctcgagaac ctgatcgccc agctgccggg cgagaagaag     1920

aacggcctgt tcgggaatct cattgcgctc agcctggggc tcacgcccaa cttcaagtcg     1980

aatttcgatc tcgctgagga cgccaagctg cagctctcca aggacacata cgacgatgac     2040

ctggataacc tcctggccca gatcggcgat cagtacgcgg acctgttcct cgctgccaag     2100

aatctgtcgg acgccatcct cctgtctgat attctcaggg tgaacaccga gattacgaag     2160

gctccgctct cagcctccat gatcaagcgc tacgacgagc accatcagga tctgaccctc     2220

ctgaaggcgc tggtcaggca gcagctcccc gagaagtaca aggagatctt cttcgatcag     2280

tcgaagaacg gctacgctgg gtacattgac ggcggggcct ctcaggagga gttctacaag     2340

ttcatcaagc cgattctgga gaagatggac ggcacggagg agctgctggt gaagctcaat     2400

cgcgaggacc tcctgaggaa gcagcggaca ttcgataacg gcagcatccc acaccagatt     2460

catctcgggg agctgcacgc tatcctgagg aggcaggagg acttctaccc tttcctcaag     2520

gataaccgcg agaagatcga gaagattctg actttcagga tcccgtacta cgtcggccca     2580

ctcgctaggg gcaactcccg cttcgcttgg atgacccgca agtcagagga gacgatcacg     2640

ccgtggaact tcgaggaggt ggtcgacaag ggcgctagcg ctcagtcgtt catcgagagg     2700

atgacgaatt tcgacaagaa cctgccaaat gagaaggtgc tccctaagca ctcgctcctg     2760

tacgagtact tcacagtcta caacgagctg actaaggtga agtatgtgac cgagggcatg     2820

aggaagccgg ctttcctgtc tggggagcag aagaaggcca tcgtggacct cctgttcaag     2880

accaaccgga aggtcacggt taagcagctc aaggaggact acttcaagaa gattgagtgc     2940

ttcgattcgg tcgagatctc tggcgttgag gaccgcttca acgcctccct ggggacctac     3000

cacgatctcc tgaagatcat taaggataag gacttcctgg acaacgagga gaatgaggat     3060

atcctcgagg acattgtgct gacactcact ctgttcgagg accgggagat gatcgaggag     3120

cgcctgaaga cttacgccca tctcttcgat gacaaggtca tgaagcagct caagaggagg     3180

aggtacaccg gctgggggag gctgagcagg aagctcatca acggcattcg ggacaagcag     3240

tccgggaaga cgatcctcga cttcctgaag agcgatggct tcgcgaaccg caatttcatg     3300

cagctgattc acgatgacag cctcacattc aaggaggata tccagaaggc tcaggtgagc     3360

ggccaggggg actcgctgca cgagcatatc gcgaacctcg ctggctcgcc agctatcaag     3420

aaggggattc tgcagaccgt gaaggttgtg gacgagctgg tgaaggtcat gggcaggcac     3480

aagcctgaga acatcgtcat tgagatggcc cgggagaatc agaccacgca gaagggccag     3540

aagaactcac gcgagaggat gaagaggatc gaggagggca ttaaggagct ggggtcccag     3600

atcctcaagg agcacccggt ggagaacacg cagctgcaga atgagaagct ctacctgtac     3660

tacctccaga atggccgcga tatgtatgtg gaccaggagc tggatattaa caggctcagc     3720

gattacgacg tcgatcatat cgttccacag tcattcctga aggatgactc cattgacaac     3780

aaggtcctca ccaggtcgga caagaaccgg ggcaagtctg ataatgttcc ttcagaggag     3840

gtcgttaaga agatgaagaa ctactggcgc cagctcctga atgccaagct gatcacgcag     3900

cggaagttcg ataacctcac aaaggctgag aggggcgggc tctctgagct ggacaaggcg     3960

ggcttcatca agaggcagct ggtcgagaca cggcagatca ctaagcacgt tgcgcagatt     4020

ctcgactcac ggatgaacac taagtacgat gagaatgaca agctgatccg cgaggtgaag     4080

gtcatcaccc tgaagtcaaa gctcgtctcc gacttcagga aggatttcca gttctacaag     4140

gttcgggaga tcaacaatta ccaccatgcc catgacgcgt acctgaacgc ggtggtcggc     4200

acagctctga tcaagaagta cccaaagctc gagagcgagt tcgtgtacgg ggactacaag     4260

gtttacgatg tgaggaagat gatcgccaag tcggagcagg agattggcaa ggctaccgcc     4320

aagtacttct tctactctaa cattatgaat ttcttcaaga cagagatcac tctggccaat     4380

ggcgagatcc ggaagcgccc cctcatcgag acgaacggcg agacggggga gatcgtgtgg     4440

gacaagggca gggatttcgc gaccgtcagg aaggttctct ccatgccaca agtgaatatc     4500

gtcaagaaga cagaggtcca gactggcggg ttctctaagg agtcaattct gcctaagcgg     4560

aacagcgaca agctcatcgc ccgcaagaag gactgggatc cgaagaagta cggcgggttc     4620

gtcagcccca ctgtggccta ctcggtcctg gttgtggcga aggttgagaa gggcaagtcc     4680

aagaagctca agagcgtgaa ggagctgctg gggatcacga ttatggagcg ctccagcttc     4740

gagaagaacc cgatcgattt cctggaggcg aagggctaca aggaggtgaa gaaggacctg     4800

atcattaagc tccccaagta ctcactcttc gagctggaga acggcaggaa gcggatgctg     4860

gcttccgctg gcgagctgca gaaggggaac gagctggctc tgccgtccaa gtatgtgaac     4920

ttcctctacc tggcctccca ctacgagaag ctcaagggca gccccgagga caacgagcag     4980

aagcagctgt tcgtcgagca gcacaagcat tacctcgacg agatcattga gcagatttcc     5040

gagttctcca agcgcgtgat cctggccgac gcgaatctgg ataaggtcct ctccgcgtac     5100

aacaagcacc gcgacaagcc aatcagggag caggctgaga atatcattca tctcttcacc     5160

ctgacgaacc tcggcgcccc tgctgctttc aagtacttcg acacaactat cgatcgcaag     5220

cagtacagaa gcactaagga ggtcctggac gcgaccctca tccaccagtc gattaccggc     5280

ctctacgaga cgcgcatcga cctgtctcag ctcgggggcg acaagcggcc agcggcgacg     5340

aagaaggcgg ggcaggcgaa gaagaagaag tag                                  5373


<210>  15
<211>  5373
<212>  DNA
<213>  artificial sequence

<220>
<223>  SpnCas9-VRER-ABE-1

<400>  15
atgtccgagg tggagttctc tcacgagtat tggatgaggc acgctcttac acttgctaag       60

agagcttggg acgaaagaga agtgccagtt ggcgccgttc ttgtgcataa taatagggtg      120

atcggcgagg gttggaatag accaattgga aggcatgatc caacagctca cgcagagatt      180

atggctctca gacaaggcgg cctcgttatg cagaactaca ggctcattga cgctacactc      240

tacgtgacac tcgaaccttg cgttatgtgc gccggagcta tgattcattc taggattggc      300

agggtcgtgt ttggagctag ggacgctaaa acaggagccg ccggatctct tatggacgtg      360

ttgcatcatc caggcatgaa ccatagggtg gagattacag agggcattct tgcagacgag      420

tgcgctgctc ttctttccga tttcttcagg atgagaaggc aggagattaa ggcccagaag      480

aaggctcagt cttctacaga tagcggagga tcttccggag gatctagcgg ctccgagaca      540

ccaggaacat ccgaaagcgc tacaccagaa tctagcggag gctcttccgg aggatcttct      600

gaagtggagt tctcccacga gtattggatg aggcacgctc ttacacttgc taaaagggct      660

agggacgaaa gggaagttcc agttggagct gttctcgtgc tcaataacag ggtgattggc      720

gagggttgga atagagccat tggactccat gatccaacag ctcacgcaga gattatggct      780

cttagacaag gcggcctcgt tatgcagaat tacagactca tcgacgccac actctacgtt      840

accttcgaac cttgcgttat gtgcgccgga gctatgatcc attctaggat tggcagggtc      900

gtgttcggcg ttagaaacgc taagacagga gctgcaggct ctcttatgga cgttcttcat      960

tacccaggca tgaatcatag agtggagatc acagaaggca ttcttgcaga cgagtgcgca     1020

gctctccttt gctatttctt caggatgccg aggcaagttt tcaacgctca gaagaaggcc     1080

cagtcttcta cagattccgg cggatcttct ggaggatcta gcggctccga gacaccagga     1140

acatccgaat ccgctacacc agagtcttct ggaggatcta gcggaggatc tcttaagggc     1200

atccacgggg tgccagctgc tgacaagaag tactcgatcg gcctcgatat tgggactaac     1260

tctgttggct gggccgtgat caccgacgag tacaaggtgc cctcaaagaa gttcaaggtc     1320

ctgggcaaca ccgatcggca ttccatcaag aagaatctca ttggcgctct cctgttcgac     1380

agcggcgaga cggctgaggc tacgcggctc aagcgcaccg cccgcaggcg gtacacgcgc     1440

aggaagaatc gcatctgcta cctgcaggag attttctcca acgagatggc gaaggttgac     1500

gattctttct tccacaggct ggaggagtca ttcctcgtgg aggaggataa gaagcacgag     1560

cggcatccaa tcttcggcaa cattgtcgac gaggttgcct accacgagaa gtaccctacg     1620

atctaccatc tgcggaagaa gctcgtggac tccacagata aggcggacct ccgcctgatc     1680

tacctcgctc tggcccacat gattaagttc aggggccatt tcctgatcga gggggatctc     1740

aacccggaca atagcgatgt tgacaagctg ttcatccagc tcgtgcagac gtacaaccag     1800

ctcttcgagg agaaccccat taatgcgtca ggcgtcgacg cgaaggctat cctgtccgct     1860

aggctctcga agtctcggcg cctcgagaac ctgatcgccc agctgccggg cgagaagaag     1920

aacggcctgt tcgggaatct cattgcgctc agcctggggc tcacgcccaa cttcaagtcg     1980

aatttcgatc tcgctgagga cgccaagctg cagctctcca aggacacata cgacgatgac     2040

ctggataacc tcctggccca gatcggcgat cagtacgcgg acctgttcct cgctgccaag     2100

aatctgtcgg acgccatcct cctgtctgat attctcaggg tgaacaccga gattacgaag     2160

gctccgctct cagcctccat gatcaagcgc tacgacgagc accatcagga tctgaccctc     2220

ctgaaggcgc tggtcaggca gcagctcccc gagaagtaca aggagatctt cttcgatcag     2280

tcgaagaacg gctacgctgg gtacattgac ggcggggcct ctcaggagga gttctacaag     2340

ttcatcaagc cgattctgga gaagatggac ggcacggagg agctgctggt gaagctcaat     2400

cgcgaggacc tcctgaggaa gcagcggaca ttcgataacg gcagcatccc acaccagatt     2460

catctcgggg agctgcacgc tatcctgagg aggcaggagg acttctaccc tttcctcaag     2520

gataaccgcg agaagatcga gaagattctg actttcagga tcccgtacta cgtcggccca     2580

ctcgctaggg gcaactcccg cttcgcttgg atgacccgca agtcagagga gacgatcacg     2640

ccgtggaact tcgaggaggt ggtcgacaag ggcgctagcg ctcagtcgtt catcgagagg     2700

atgacgaatt tcgacaagaa cctgccaaat gagaaggtgc tccctaagca ctcgctcctg     2760

tacgagtact tcacagtcta caacgagctg actaaggtga agtatgtgac cgagggcatg     2820

aggaagccgg ctttcctgtc tggggagcag aagaaggcca tcgtggacct cctgttcaag     2880

accaaccgga aggtcacggt taagcagctc aaggaggact acttcaagaa gattgagtgc     2940

ttcgattcgg tcgagatctc tggcgttgag gaccgcttca acgcctccct ggggacctac     3000

cacgatctcc tgaagatcat taaggataag gacttcctgg acaacgagga gaatgaggat     3060

atcctcgagg acattgtgct gacactcact ctgttcgagg accgggagat gatcgaggag     3120

cgcctgaaga cttacgccca tctcttcgat gacaaggtca tgaagcagct caagaggagg     3180

aggtacaccg gctgggggag gctgagcagg aagctcatca acggcattcg ggacaagcag     3240

tccgggaaga cgatcctcga cttcctgaag agcgatggct tcgcgaaccg caatttcatg     3300

cagctgattc acgatgacag cctcacattc aaggaggata tccagaaggc tcaggtgagc     3360

ggccaggggg actcgctgca cgagcatatc gcgaacctcg ctggctcgcc agctatcaag     3420

aaggggattc tgcagaccgt gaaggttgtg gacgagctgg tgaaggtcat gggcaggcac     3480

aagcctgaga acatcgtcat tgagatggcc cgggagaatc agaccacgca gaagggccag     3540

aagaactcac gcgagaggat gaagaggatc gaggagggca ttaaggagct ggggtcccag     3600

atcctcaagg agcacccggt ggagaacacg cagctgcaga atgagaagct ctacctgtac     3660

tacctccaga atggccgcga tatgtatgtg gaccaggagc tggatattaa caggctcagc     3720

gattacgacg tcgatcatat cgttccacag tcattcctga aggatgactc cattgacaac     3780

aaggtcctca ccaggtcgga caagaaccgg ggcaagtctg ataatgttcc ttcagaggag     3840

gtcgttaaga agatgaagaa ctactggcgc cagctcctga atgccaagct gatcacgcag     3900

cggaagttcg ataacctcac aaaggctgag aggggcgggc tctctgagct ggacaaggcg     3960

ggcttcatca agaggcagct ggtcgagaca cggcagatca ctaagcacgt tgcgcagatt     4020

ctcgactcac ggatgaacac taagtacgat gagaatgaca agctgatccg cgaggtgaag     4080

gtcatcaccc tgaagtcaaa gctcgtctcc gacttcagga aggatttcca gttctacaag     4140

gttcgggaga tcaacaatta ccaccatgcc catgacgcgt acctgaacgc ggtggtcggc     4200

acagctctga tcaagaagta cccaaagctc gagagcgagt tcgtgtacgg ggactacaag     4260

gtttacgatg tgaggaagat gatcgccaag tcggagcagg agattggcaa ggctaccgcc     4320

aagtacttct tctactctaa cattatgaat ttcttcaaga cagagatcac tctggccaat     4380

ggcgagatcc ggaagcgccc cctcatcgag acgaacggcg agacggggga gatcgtgtgg     4440

gacaagggca gggatttcgc gaccgtcagg aaggttctct ccatgccaca agtgaatatc     4500

gtcaagaaga cagaggtcca gactggcggg ttctctaagg agtcaattct gcctaagcgg     4560

aacagcgaca agctcatcgc ccgcaagaag gactgggatc cgaagaagta cggcgggttc     4620

gtcagcccca ctgtggccta ctcggtcctg gttgtggcga aggttgagaa gggcaagtcc     4680

aagaagctca agagcgtgaa ggagctgctg gggatcacga ttatggagcg ctccagcttc     4740

gagaagaacc cgatcgattt cctggaggcg aagggctaca aggaggtgaa gaaggacctg     4800

atcattaagc tccccaagta ctcactcttc gagctggaga acggcaggaa gcggatgctg     4860

gcttccgctc gcgagctgca gaaggggaac gagctggctc tgccgtccaa gtatgtgaac     4920

ttcctctacc tggcctccca ctacgagaag ctcaagggca gccccgagga caacgagcag     4980

aagcagctgt tcgtcgagca gcacaagcat tacctcgacg agatcattga gcagatttcc     5040

gagttctcca agcgcgtgat cctggccgac gcgaatctgg ataaggtcct ctccgcgtac     5100

aacaagcacc gcgacaagcc aatcagggag caggctgaga atatcattca tctcttcacc     5160

ctgacgaacc tcggcgcccc tgctgctttc aagtacttcg acacaactat cgatcgcaag     5220

gagtacagaa gcactaagga ggtcctggac gcgaccctca tccaccagtc gattaccggc     5280

ctctacgaga cgcgcatcga cctgtctcag ctcgggggcg acaagcggcc agcggcgacg     5340

aagaaggcgg ggcaggcgaa gaagaagaag tag                                  5373


<210>  16
<211>  2427
<212>  DNA
<213>  artificial sequence

<220>
<223>  SanCas9-ABE-1

<400>  16
atgtccgagg tggagttctc tcacgagtat tggatgaggc acgctcttac acttgctaag       60

agagcttggg acgaaagaga agtgccagtt ggcgccgttc ttgtgcataa taatagggtg      120

atcggcgagg gttggaatag accaattgga aggcatgatc caacagctca cgcagagatt      180

atggctctca gacaaggcgg cctcgttatg cagaactaca ggctcattga cgctacactc      240

tacgtgacac tcgaaccttg cgttatgtgc gccggagcta tgattcattc taggattggc      300

agggtcgtgt ttggagctag ggacgctaaa acaggagccg ccggatctct tatggacgtg      360

ttgcatcatc caggcatgaa ccatagggtg gagattacag agggcattct tgcagacgag      420

tgcgctgctc ttctttccga tttcttcagg atgagaaggc aggagattaa ggcccagaag      480

aaggctcagt cttctacaga tagcggagga tcttccggag gatctagcgg ctccgagaca      540

ccaggaacat ccgaaagcgc tacaccagaa tctagcggag gctcttccgg aggatcttct      600

gaagtggagt tctcccacga gtattggatg aggcacgctc ttacacttgc taaaagggct      660

agggacgaaa gggaagttcc agttggagct gttctcgtgc tcaataacag ggtgattggc      720

gagggttgga atagagccat tggactccat gatccaacag ctcacgcaga gattatggct      780

cttagacaag gcggcctcgt tatgcagaat tacagactca tcgacgccac actctacgtt      840

accttcgaac cttgcgttat gtgcgccgga gctatgatcc attctaggat tggcagggtc      900

gtgttcggcg ttagaaacgc taagacagga gctgcaggct ctcttatgga cgttcttcat      960

tacccaggca tgaatcatag agtggagatc acagaaggca ttcttgcaga cgagtgcgca     1020

gctctccttt gctatttctt caggatgccg aggcaagttt tcaacgctca gaagaaggcc     1080

cagtcttcta cagattccgg cggatcttct ggaggatcta gcggctccga gacaccagga     1140

acatccgaat ccgctacacc agagtcttct ggaggatcta gcggaggatc tcttaagatg     1200

ccaaaaaaga agagaaaggt ttcaggcggc tcctccgagg tggagttctc tcacgagtat     1260

tggatgaggc acgctcttac acttgctaag agagcttggg acgaaagaga agtgccagtt     1320

ggcgccgttc ttgtgcataa taatagggtg atcggcgagg gttggaatag accaattgga     1380

aggcatgatc caacagctca cgcagagatt atggctctca gacaaggcgg cctcgttatg     1440

cagaactaca ggctcattga cgctacactc tacgtgacac tcgaaccttg cgttatgtgc     1500

gccggagcta tgattcattc taggattggc agggtcgtgt ttggagctag ggacgctaaa     1560

acaggagccg ccggatctct tatggacgtg ttgcatcatc caggcatgaa ccatagggtg     1620

gagattacag agggcattct tgcagacgag tgcgctgctc ttctttccga tttcttcagg     1680

atgagaaggc aggagattaa ggcccagaag aaggctcagt cttctacaga tagcggagga     1740

tcttccggag gatctagcgg ctccgagaca ccaggaacat ccgaaagcgc tacaccagaa     1800

tctagcggag gctcttccgg aggatcttct gaagtggagt tctcccacga gtattggatg     1860

aggcacgctc ttacacttgc taaaagggct agggacgaaa gggaagttcc agttggagct     1920

gttctcgtgc tcaataacag ggtgattggc gagggttgga atagagccat tggactccat     1980

gatccaacag ctcacgcaga gattatggct cttagacaag gcggcctcgt tatgcagaat     2040

tacagactca tcgacgccac actctacgtt accttcgaac cttgcgttat gtgcgccgga     2100

gctatgatcc attctaggat tggcagggtc gtgttcggcg ttagaaacgc taagacagga     2160

gctgcaggct ctcttatgga cgttcttcat tacccaggca tgaatcatag agtggagatc     2220

acagaaggca ttcttgcaga cgagtgcgca gctctccttt gctatttctt caggatgccg     2280

aggcaagttt tcaacgctca gaagaaggcc cagtcttcta cagattccgg cggatcttct     2340

ggaggatcta gcggctccga gacaccagga acatccgaat ccgctacacc agagtcttct     2400

ggaggatcta gcggaggatc tcttaag                                         2427


<210>  17
<211>  4398
<212>  DNA
<213>  artificial sequence

<220>
<223>  SanCas9-KKH-ABE -1

<400>  17
atgtccgagg tggagttctc tcacgagtat tggatgaggc acgctcttac acttgctaag       60

agagcttggg acgaaagaga agtgccagtt ggcgccgttc ttgtgcataa taatagggtg      120

atcggcgagg gttggaatag accaattgga aggcatgatc caacagctca cgcagagatt      180

atggctctca gacaaggcgg cctcgttatg cagaactaca ggctcattga cgctacactc      240

tacgtgacac tcgaaccttg cgttatgtgc gccggagcta tgattcattc taggattggc      300

agggtcgtgt ttggagctag ggacgctaaa acaggagccg ccggatctct tatggacgtg      360

ttgcatcatc caggcatgaa ccatagggtg gagattacag agggcattct tgcagacgag      420

tgcgctgctc ttctttccga tttcttcagg atgagaaggc aggagattaa ggcccagaag      480

aaggctcagt cttctacaga tagcggagga tcttccggag gatctagcgg ctccgagaca      540

ccaggaacat ccgaaagcgc tacaccagaa tctagcggag gctcttccgg aggatcttct      600

gaagtggagt tctcccacga gtattggatg aggcacgctc ttacacttgc taaaagggct      660

agggacgaaa gggaagttcc agttggagct gttctcgtgc tcaataacag ggtgattggc      720

gagggttgga atagagccat tggactccat gatccaacag ctcacgcaga gattatggct      780

cttagacaag gcggcctcgt tatgcagaat tacagactca tcgacgccac actctacgtt      840

accttcgaac cttgcgttat gtgcgccgga gctatgatcc attctaggat tggcagggtc      900

gtgttcggcg ttagaaacgc taagacagga gctgcaggct ctcttatgga cgttcttcat      960

tacccaggca tgaatcatag agtggagatc acagaaggca ttcttgcaga cgagtgcgca     1020

gctctccttt gctatttctt caggatgccg aggcaagttt tcaacgctca gaagaaggcc     1080

cagtcttcta cagattccgg cggatcttct ggaggatcta gcggctccga gacaccagga     1140

acatccgaat ccgctacacc agagtcttct ggaggatcta gcggaggatc taagaggaac     1200

tacatcctcg ggctggatat tggcatcacc tctgtgggct acgggatcat tgactacgag     1260

acgcgggatg tcatcgacgc tggcgttcgc ctgttcaagg aggccaacgt cgagaacaat     1320

gaggggagga ggtccaagag gggcgcccgc aggctcaaga ggaggaggag gcacaggatc     1380

cagagggtga agaagctcct gttcgattac aacctcctga ccgaccattc ggagctgtct     1440

gggatcaatc cgtacgaggc ccgcgtcaag ggcctgtctc agaagctctc agaggaggag     1500

ttcagcgctg ccctcctgca cctcgctaag cgcaggggcg tccataacgt taatgaggtg     1560

gaggaggaca caggcaacga gctgtcgact aaggagcaga tctcccgcaa ctccaaggcg     1620

ctggaggaga agtatgtggc tgagctgcag ctggagcgcc tcaagaagga tggggaggtc     1680

cggggctcaa tcaaccgctt caagacatcc gactacgtca aggaggccaa gcagctcctg     1740

aaggttcaga aggcgtacca ccagctggac cagtcattca ttgatactta catcgacctc     1800

ctcgagacga ggcggacgta ctacgagggc ccaggggagg gctccccctt cgggtggaag     1860

gacatcaagg agtggtacga gatgctgatg ggccattgca cgtacttccc ggaggagctg     1920

aggagcgtta agtacgctta caacgccgat ctgtacaacg cgctcaatga cctgaacaat     1980

ctcgtcatca cccgggacga gaacgagaag ctcgagtact acgagaagtt ccagatcatt     2040

gagaatgtgt tcaagcagaa gaagaagcca acgctgaagc agattgcgaa ggagatcctc     2100

gttaacgagg aggacatcaa ggggtacagg gtgacctcga cgggcaagcc tgagttcaca     2160

aacctgaagg tctaccacga tattaaggac atcactgcca ggaaggagat cattgagaac     2220

gccgagctgc tcgaccagat tgcgaagatc ctcacgatct accagtccag cgaggacatc     2280

caggaggagc tgaccaacct caattcggag ctgacgcagg aggagatcga gcagatttct     2340

aacctgaagg ggtacacagg cactcacaac ctcagcctga aggcgatcaa tctcattctg     2400

gatgagctgt ggcatacaaa cgacaatcag attgctatct tcaacaggct caagctggtg     2460

ccaaagaagg tcgacctctc tcagcagaag gagatcccga ccacgctggt ggacgatttc     2520

attctctcac ccgtggtcaa gaggtccttc atccagagca ttaaggtcat caacgccatc     2580

attaagaagt acggcctgcc caatgatatc attatcgagc tggcgcgcga gaagaactcc     2640

aaggacgctc agaagatgat caatgagatg cagaagcgga accgccagac caatgagagg     2700

atcgaggaga ttatccggac aactggcaag gagaacgcta agtacctgat tgagaagatc     2760

aagctccacg atatgcagga gggcaagtgc ctgtactccc tcgaggccat cccactggag     2820

gacctcctga acaatccttt caactacgag gttgatcata ttatcccgag gtccgtgagc     2880

ttcgacaata gcttcaacaa taaggtcctg gttaagcaag aggagaactc gaagaagggc     2940

aatcgcaccc ccttccagta cctctcgtct tcagacagca agatctcgta cgagacgttc     3000

aagaagcaca ttctcaacct ggcgaagggg aagggcagga tctccaagac caagaaggag     3060

tacctcctgg aggagcggga catcaaccgc ttcagcgtcc agaaggattt cattaaccgg     3120

aatctggttg acacacgcta cgccactcgg ggcctcatga acctcctgcg ctcctacttc     3180

agggtgaaca atctggacgt gaaggtcaag agcatcaacg gcgggttcac gtcgttcctc     3240

cgcaggaagt ggaagttcaa gaaggagagg aacaagggct acaagcacca tgcggaggat     3300

gctctgatta tcgccaatgc ggacttcatc ttcaaggagt ggaagaagct cgacaaggcc     3360

aagaaggtca tggagaacca gatgttcgag gagaagcagg ccgagagcat gccagagatc     3420

gagacagagc aggagtacaa ggagattttc atcactcctc accagattaa gcatatcaag     3480

gatttcaagg actacaagta ctcgcaccgc gtggataaga agccgaacag gaagctgatc     3540

aatgacaccc tctactctac gcgcaaggac gataagggga acacactcat cgtcaacaat     3600

ctgaacggcc tctacgacaa ggataatgac aagctgaaga agctcatcaa caagagccca     3660

gagaagctcc tgatgtacca ccatgatcct cagacttacc agaagctcaa gctgatcatg     3720

gagcagtacg gcgacgagaa gaacccgctc tacaagtact acgaggagac aggcaactac     3780

ctgactaagt actcgaagaa ggataatggg cccgtgatta agaagatcaa gtactacggc     3840

aacaagctga atgcgcatct cgacatcacc gacgattacc cgaactctcg caataaggtt     3900

gtgaagctct cactgaagcc ctacaggttc gatgtgtacc tggacaacgg cgtctacaag     3960

ttcgttacgg tgaagaatct cgacgtgatc aagaaggaga actactacga ggtcaattcc     4020

aagtgctacg aggaggccaa gaagctgaag aagatttcca accaggctga gttcatcgcc     4080

agcttctaca agaatgacct gattaagatc aacggggagc tgtacagggt catcggcgtt     4140

aacaatgatc tcctgaaccg gattgaagtg aatatgattg acatcaccta ccgcgagtac     4200

ctcgagaaca tgaatgataa gcgcccgccc cacattatca agaccattgc ctcgaagacg     4260

cagtctatca agaagtactc aacagacatt ctgggcaacc tctacgaggt caagtccaag     4320

aagcacccgc agattatcaa gaagggcaag cgcccggccg ccactaagaa ggctgggcag     4380

gccaagaaga agaagtag                                                   4398


<210>  18
<211>  1801
<212>  PRT
<213>  artificial sequence

<220>
<223>  SpnCas9-VQR-ABE

<400>  18

Met Pro Lys Lys Lys Arg Lys Val Ser Gly Gly Ser Ser Glu Val Glu 
1               5                   10                  15      


Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg 
            20                  25                  30          


Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn 
        35                  40                  45              


Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp 
    50                  55                  60                  


Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val 
65                  70                  75                  80  


Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Leu Glu 
                85                  90                  95      


Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg 
            100                 105                 110         


Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu 
        115                 120                 125             


Met Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr 
    130                 135                 140                 


Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe 
145                 150                 155                 160 


Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser 
                165                 170                 175     


Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro 
            180                 185                 190         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly 
        195                 200                 205             


Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala 
    210                 215                 220                 


Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly 
225                 230                 235                 240 


Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg 
                245                 250                 255     


Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu 
            260                 265                 270         


Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr 
        275                 280                 285             


Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile 
    290                 295                 300                 


His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr 
305                 310                 315                 320 


Gly Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn 
                325                 330                 335     


His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala 
            340                 345                 350         


Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln 
        355                 360                 365             


Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser 
    370                 375                 380                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Leu Lys Gly Ile His Gly Val Pro 
                405                 410                 415     


Ala Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
            420                 425                 430         


Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys 
        435                 440                 445             


Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu 
    450                 455                 460                 


Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
465                 470                 475                 480 


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile 
                485                 490                 495     


Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp 
            500                 505                 510         


Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys 
        515                 520                 525             


Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala 
    530                 535                 540                 


Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val 
545                 550                 555                 560 


Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
                565                 570                 575     


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn 
            580                 585                 590         


Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr 
        595                 600                 605             


Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp 
    610                 615                 620                 


Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu 
625                 630                 635                 640 


Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly 
                645                 650                 655     


Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn 
            660                 665                 670         


Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr 
        675                 680                 685             


Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala 
    690                 695                 700                 


Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser 
705                 710                 715                 720 


Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala 
                725                 730                 735     


Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu 
            740                 745                 750         


Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe 
        755                 760                 765             


Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala 
    770                 775                 780                 


Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met 
785                 790                 795                 800 


Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu 
                805                 810                 815     


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
            820                 825                 830         


Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro 
        835                 840                 845             


Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
    850                 855                 860                 


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala 
865                 870                 875                 880 


Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu 
                885                 890                 895     


Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met 
            900                 905                 910         


Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His 
        915                 920                 925             


Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
    930                 935                 940                 


Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu 
945                 950                 955                 960 


Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val 
                965                 970                 975     


Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe 
            980                 985                 990         


Asp Ser Val Glu Ile Ser Gly Val  Glu Asp Arg Phe Asn  Ala Ser Leu 
        995                 1000                 1005             


Gly Thr  Tyr His Asp Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe 
    1010                 1015                 1020             


Leu Asp  Asn Glu Glu Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu 
    1025                 1030                 1035             


Thr Leu  Thr Leu Phe Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu 
    1040                 1045                 1050             


Lys Thr  Tyr Ala His Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu 
    1055                 1060                 1065             


Lys Arg  Arg Arg Tyr Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu 
    1070                 1075                 1080             


Ile Asn  Gly Ile Arg Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp 
    1085                 1090                 1095             


Phe Leu  Lys Ser Asp Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu 
    1100                 1105                 1110             


Ile His  Asp Asp Ser Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala 
    1115                 1120                 1125             


Gln Val  Ser Gly Gln Gly Asp  Ser Leu His Glu His  Ile Ala Asn 
    1130                 1135                 1140             


Leu Ala  Gly Ser Pro Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val 
    1145                 1150                 1155             


Lys Val  Val Asp Glu Leu Val  Lys Val Met Gly Arg  His Lys Pro 
    1160                 1165                 1170             


Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln 
    1175                 1180                 1185             


Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu 
    1190                 1195                 1200             


Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu Lys Glu  His Pro Val 
    1205                 1210                 1215             


Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu 
    1220                 1225                 1230             


Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn 
    1235                 1240                 1245             


Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile Val Pro  Gln Ser Phe 
    1250                 1255                 1260             


Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp 
    1265                 1270                 1275             


Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro Ser Glu  Glu Val Val 
    1280                 1285                 1290             


Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu 
    1295                 1300                 1305             


Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly 
    1310                 1315                 1320             


Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu 
    1325                 1330                 1335             


Val Glu  Thr Arg Gln Ile Thr  Lys His Val Ala Gln  Ile Leu Asp 
    1340                 1345                 1350             


Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
    1355                 1360                 1365             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1370                 1375                 1380             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1385                 1390                 1395             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1400                 1405                 1410             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1415                 1420                 1425             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1430                 1435                 1440             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1445                 1450                 1455             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1460                 1465                 1470             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1475                 1480                 1485             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1490                 1495                 1500             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1505                 1510                 1515             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1520                 1525                 1530             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1535                 1540                 1545             


Gly Gly  Phe Val Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1550                 1555                 1560             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1565                 1570                 1575             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1580                 1585                 1590             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1595                 1600                 1605             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1610                 1615                 1620             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Gly  Glu Leu Gln 
    1625                 1630                 1635             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1640                 1645                 1650             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1655                 1660                 1665             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1670                 1675                 1680             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1685                 1690                 1695             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1700                 1705                 1710             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1715                 1720                 1725             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1730                 1735                 1740             


Phe Asp  Thr Thr Ile Asp Arg  Lys Gln Tyr Arg Ser  Thr Lys Glu 
    1745                 1750                 1755             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1760                 1765                 1770             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Lys Arg Pro 
    1775                 1780                 1785             


Ala Ala  Thr Lys Lys Ala Gly  Gln Ala Lys Lys Lys  Lys 
    1790                 1795                 1800     


<210>  19
<211>  1801
<212>  PRT
<213>  artificial sequence

<220>
<223>  SpnCas9-VRER-ABE

<400>  19

Met Pro Lys Lys Lys Arg Lys Val Ser Gly Gly Ser Ser Glu Val Glu 
1               5                   10                  15      


Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg 
            20                  25                  30          


Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn 
        35                  40                  45              


Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp 
    50                  55                  60                  


Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val 
65                  70                  75                  80  


Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Leu Glu 
                85                  90                  95      


Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg 
            100                 105                 110         


Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu 
        115                 120                 125             


Met Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr 
    130                 135                 140                 


Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe 
145                 150                 155                 160 


Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser 
                165                 170                 175     


Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro 
            180                 185                 190         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly 
        195                 200                 205             


Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala 
    210                 215                 220                 


Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly 
225                 230                 235                 240 


Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg 
                245                 250                 255     


Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu 
            260                 265                 270         


Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr 
        275                 280                 285             


Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile 
    290                 295                 300                 


His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr 
305                 310                 315                 320 


Gly Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn 
                325                 330                 335     


His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala 
            340                 345                 350         


Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln 
        355                 360                 365             


Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser 
    370                 375                 380                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Leu Lys Gly Ile His Gly Val Pro 
                405                 410                 415     


Ala Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
            420                 425                 430         


Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys 
        435                 440                 445             


Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu 
    450                 455                 460                 


Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
465                 470                 475                 480 


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile 
                485                 490                 495     


Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp 
            500                 505                 510         


Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys 
        515                 520                 525             


Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala 
    530                 535                 540                 


Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val 
545                 550                 555                 560 


Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
                565                 570                 575     


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn 
            580                 585                 590         


Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr 
        595                 600                 605             


Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp 
    610                 615                 620                 


Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu 
625                 630                 635                 640 


Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly 
                645                 650                 655     


Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn 
            660                 665                 670         


Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr 
        675                 680                 685             


Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala 
    690                 695                 700                 


Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser 
705                 710                 715                 720 


Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala 
                725                 730                 735     


Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu 
            740                 745                 750         


Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe 
        755                 760                 765             


Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala 
    770                 775                 780                 


Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met 
785                 790                 795                 800 


Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu 
                805                 810                 815     


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
            820                 825                 830         


Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro 
        835                 840                 845             


Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
    850                 855                 860                 


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala 
865                 870                 875                 880 


Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu 
                885                 890                 895     


Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met 
            900                 905                 910         


Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His 
        915                 920                 925             


Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
    930                 935                 940                 


Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu 
945                 950                 955                 960 


Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val 
                965                 970                 975     


Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe 
            980                 985                 990         


Asp Ser Val Glu Ile Ser Gly Val  Glu Asp Arg Phe Asn  Ala Ser Leu 
        995                 1000                 1005             


Gly Thr  Tyr His Asp Leu Leu  Lys Ile Ile Lys Asp  Lys Asp Phe 
    1010                 1015                 1020             


Leu Asp  Asn Glu Glu Asn Glu  Asp Ile Leu Glu Asp  Ile Val Leu 
    1025                 1030                 1035             


Thr Leu  Thr Leu Phe Glu Asp  Arg Glu Met Ile Glu  Glu Arg Leu 
    1040                 1045                 1050             


Lys Thr  Tyr Ala His Leu Phe  Asp Asp Lys Val Met  Lys Gln Leu 
    1055                 1060                 1065             


Lys Arg  Arg Arg Tyr Thr Gly  Trp Gly Arg Leu Ser  Arg Lys Leu 
    1070                 1075                 1080             


Ile Asn  Gly Ile Arg Asp Lys  Gln Ser Gly Lys Thr  Ile Leu Asp 
    1085                 1090                 1095             


Phe Leu  Lys Ser Asp Gly Phe  Ala Asn Arg Asn Phe  Met Gln Leu 
    1100                 1105                 1110             


Ile His  Asp Asp Ser Leu Thr  Phe Lys Glu Asp Ile  Gln Lys Ala 
    1115                 1120                 1125             


Gln Val  Ser Gly Gln Gly Asp  Ser Leu His Glu His  Ile Ala Asn 
    1130                 1135                 1140             


Leu Ala  Gly Ser Pro Ala Ile  Lys Lys Gly Ile Leu  Gln Thr Val 
    1145                 1150                 1155             


Lys Val  Val Asp Glu Leu Val  Lys Val Met Gly Arg  His Lys Pro 
    1160                 1165                 1170             


Glu Asn  Ile Val Ile Glu Met  Ala Arg Glu Asn Gln  Thr Thr Gln 
    1175                 1180                 1185             


Lys Gly  Gln Lys Asn Ser Arg  Glu Arg Met Lys Arg  Ile Glu Glu 
    1190                 1195                 1200             


Gly Ile  Lys Glu Leu Gly Ser  Gln Ile Leu Lys Glu  His Pro Val 
    1205                 1210                 1215             


Glu Asn  Thr Gln Leu Gln Asn  Glu Lys Leu Tyr Leu  Tyr Tyr Leu 
    1220                 1225                 1230             


Gln Asn  Gly Arg Asp Met Tyr  Val Asp Gln Glu Leu  Asp Ile Asn 
    1235                 1240                 1245             


Arg Leu  Ser Asp Tyr Asp Val  Asp His Ile Val Pro  Gln Ser Phe 
    1250                 1255                 1260             


Leu Lys  Asp Asp Ser Ile Asp  Asn Lys Val Leu Thr  Arg Ser Asp 
    1265                 1270                 1275             


Lys Asn  Arg Gly Lys Ser Asp  Asn Val Pro Ser Glu  Glu Val Val 
    1280                 1285                 1290             


Lys Lys  Met Lys Asn Tyr Trp  Arg Gln Leu Leu Asn  Ala Lys Leu 
    1295                 1300                 1305             


Ile Thr  Gln Arg Lys Phe Asp  Asn Leu Thr Lys Ala  Glu Arg Gly 
    1310                 1315                 1320             


Gly Leu  Ser Glu Leu Asp Lys  Ala Gly Phe Ile Lys  Arg Gln Leu 
    1325                 1330                 1335             


Val Glu  Thr Arg Gln Ile Thr  Lys His Val Ala Gln  Ile Leu Asp 
    1340                 1345                 1350             


Ser Arg  Met Asn Thr Lys Tyr  Asp Glu Asn Asp Lys  Leu Ile Arg 
    1355                 1360                 1365             


Glu Val  Lys Val Ile Thr Leu  Lys Ser Lys Leu Val  Ser Asp Phe 
    1370                 1375                 1380             


Arg Lys  Asp Phe Gln Phe Tyr  Lys Val Arg Glu Ile  Asn Asn Tyr 
    1385                 1390                 1395             


His His  Ala His Asp Ala Tyr  Leu Asn Ala Val Val  Gly Thr Ala 
    1400                 1405                 1410             


Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser Glu Phe  Val Tyr Gly 
    1415                 1420                 1425             


Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met Ile Ala  Lys Ser Glu 
    1430                 1435                 1440             


Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr Phe Phe  Tyr Ser Asn 
    1445                 1450                 1455             


Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr Leu Ala  Asn Gly Glu 
    1460                 1465                 1470             


Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn Gly Glu  Thr Gly Glu 
    1475                 1480                 1485             


Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala Thr Val  Arg Lys Val 
    1490                 1495                 1500             


Leu Ser  Met Pro Gln Val Asn  Ile Val Lys Lys Thr  Glu Val Gln 
    1505                 1510                 1515             


Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu Pro Lys  Arg Asn Ser 
    1520                 1525                 1530             


Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp Asp Pro  Lys Lys Tyr 
    1535                 1540                 1545             


Gly Gly  Phe Val Ser Pro Thr  Val Ala Tyr Ser Val  Leu Val Val 
    1550                 1555                 1560             


Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys Leu Lys  Ser Val Lys 
    1565                 1570                 1575             


Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg Ser Ser  Phe Glu Lys 
    1580                 1585                 1590             


Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly Tyr Lys  Glu Val Lys 
    1595                 1600                 1605             


Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr Ser Leu  Phe Glu Leu 
    1610                 1615                 1620             


Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser Ala Arg  Glu Leu Gln 
    1625                 1630                 1635             


Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys Tyr Val  Asn Phe Leu 
    1640                 1645                 1650             


Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys Gly Ser  Pro Glu Asp 
    1655                 1660                 1665             


Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln His Lys  His Tyr Leu 
    1670                 1675                 1680             


Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe Ser Lys  Arg Val Ile 
    1685                 1690                 1695             


Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu Ser Ala  Tyr Asn Lys 
    1700                 1705                 1710             


His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala Glu Asn  Ile Ile His 
    1715                 1720                 1725             


Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro Ala Ala  Phe Lys Tyr 
    1730                 1735                 1740             


Phe Asp  Thr Thr Ile Asp Arg  Lys Glu Tyr Arg Ser  Thr Lys Glu 
    1745                 1750                 1755             


Val Leu  Asp Ala Thr Leu Ile  His Gln Ser Ile Thr  Gly Leu Tyr 
    1760                 1765                 1770             


Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly Gly Asp  Lys Arg Pro 
    1775                 1780                 1785             


Ala Ala  Thr Lys Lys Ala Gly  Gln Ala Lys Lys Lys  Lys 
    1790                 1795                 1800     


<210>  20
<211>  1478
<212>  PRT
<213>  artificial sequence

<220>
<223>  SanCas9-ABE

<400>  20

Met Pro Lys Lys Lys Arg Lys Val Ser Gly Gly Ser Ser Glu Val Glu 
1               5                   10                  15      


Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg 
            20                  25                  30          


Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn 
        35                  40                  45              


Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp 
    50                  55                  60                  


Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val 
65                  70                  75                  80  


Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Leu Glu 
                85                  90                  95      


Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg 
            100                 105                 110         


Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu 
        115                 120                 125             


Met Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr 
    130                 135                 140                 


Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe 
145                 150                 155                 160 


Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser 
                165                 170                 175     


Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro 
            180                 185                 190         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly 
        195                 200                 205             


Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala 
    210                 215                 220                 


Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly 
225                 230                 235                 240 


Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg 
                245                 250                 255     


Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu 
            260                 265                 270         


Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr 
        275                 280                 285             


Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile 
    290                 295                 300                 


His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr 
305                 310                 315                 320 


Gly Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn 
                325                 330                 335     


His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala 
            340                 345                 350         


Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln 
        355                 360                 365             


Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser 
    370                 375                 380                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Leu Lys Lys Arg Asn Tyr Ile Leu 
                405                 410                 415     


Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr 
            420                 425                 430         


Glu Thr Arg Asp Val Ile Asp Ala Gly Val Arg Leu Phe Lys Glu Ala 
        435                 440                 445             


Asn Val Glu Asn Asn Glu Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg 
    450                 455                 460                 


Leu Lys Arg Arg Arg Arg His Arg Ile Gln Arg Val Lys Lys Leu Leu 
465                 470                 475                 480 


Phe Asp Tyr Asn Leu Leu Thr Asp His Ser Glu Leu Ser Gly Ile Asn 
                485                 490                 495     


Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu 
            500                 505                 510         


Glu Phe Ser Ala Ala Leu Leu His Leu Ala Lys Arg Arg Gly Val His 
        515                 520                 525             


Asn Val Asn Glu Val Glu Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys 
    530                 535                 540                 


Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala 
545                 550                 555                 560 


Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp Gly Glu Val Arg Gly Ser 
                565                 570                 575     


Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu 
            580                 585                 590         


Leu Lys Val Gln Lys Ala Tyr His Gln Leu Asp Gln Ser Phe Ile Asp 
        595                 600                 605             


Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro 
    610                 615                 620                 


Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu 
625                 630                 635                 640 


Met Leu Met Gly His Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val 
                645                 650                 655     


Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn 
            660                 665                 670         


Asn Leu Val Ile Thr Arg Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu 
        675                 680                 685             


Lys Phe Gln Ile Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr 
    690                 695                 700                 


Leu Lys Gln Ile Ala Lys Glu Ile Leu Val Asn Glu Glu Asp Ile Lys 
705                 710                 715                 720 


Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys 
                725                 730                 735     


Val Tyr His Asp Ile Lys Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu 
            740                 745                 750         


Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln 
        755                 760                 765             


Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu 
    770                 775                 780                 


Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly 
785                 790                 795                 800 


Thr His Asn Leu Ser Leu Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu 
                805                 810                 815     


Trp His Thr Asn Asp Asn Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu 
            820                 825                 830         


Val Pro Lys Lys Val Asp Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr 
        835                 840                 845             


Leu Val Asp Asp Phe Ile Leu Ser Pro Val Val Lys Arg Ser Phe Ile 
    850                 855                 860                 


Gln Ser Ile Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro 
865                 870                 875                 880 


Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala 
                885                 890                 895     


Gln Lys Met Ile Asn Glu Met Gln Lys Arg Asn Arg Gln Thr Asn Glu 
            900                 905                 910         


Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr 
        915                 920                 925             


Leu Ile Glu Lys Ile Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu 
    930                 935                 940                 


Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe 
945                 950                 955                 960 


Asn Tyr Glu Val Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn 
                965                 970                 975     


Ser Phe Asn Asn Lys Val Leu Val Lys Gln Glu Glu Asn Ser Lys Lys 
            980                 985                 990         


Gly Asn Arg Thr Pro Phe Gln Tyr  Leu Ser Ser Ser Asp  Ser Lys Ile 
        995                 1000                 1005             


Ser Tyr  Glu Thr Phe Lys Lys  His Ile Leu Asn Leu  Ala Lys Gly 
    1010                 1015                 1020             


Lys Gly  Arg Ile Ser Lys Thr  Lys Lys Glu Tyr Leu  Leu Glu Glu 
    1025                 1030                 1035             


Arg Asp  Ile Asn Arg Phe Ser  Val Gln Lys Asp Phe  Ile Asn Arg 
    1040                 1045                 1050             


Asn Leu  Val Asp Thr Arg Tyr  Ala Thr Arg Gly Leu  Met Asn Leu 
    1055                 1060                 1065             


Leu Arg  Ser Tyr Phe Arg Val  Asn Asn Leu Asp Val  Lys Val Lys 
    1070                 1075                 1080             


Ser Ile  Asn Gly Gly Phe Thr  Ser Phe Leu Arg Arg  Lys Trp Lys 
    1085                 1090                 1095             


Phe Lys  Lys Glu Arg Asn Lys  Gly Tyr Lys His His  Ala Glu Asp 
    1100                 1105                 1110             


Ala Leu  Ile Ile Ala Asn Ala  Asp Phe Ile Phe Lys  Glu Trp Lys 
    1115                 1120                 1125             


Lys Leu  Asp Lys Ala Lys Lys  Val Met Glu Asn Gln  Met Phe Glu 
    1130                 1135                 1140             


Glu Lys  Gln Ala Glu Ser Met  Pro Glu Ile Glu Thr  Glu Gln Glu 
    1145                 1150                 1155             


Tyr Lys  Glu Ile Phe Ile Thr  Pro His Gln Ile Lys  His Ile Lys 
    1160                 1165                 1170             


Asp Phe  Lys Asp Tyr Lys Tyr  Ser His Arg Val Asp  Lys Lys Pro 
    1175                 1180                 1185             


Asn Arg  Glu Leu Ile Asn Asp  Thr Leu Tyr Ser Thr  Arg Lys Asp 
    1190                 1195                 1200             


Asp Lys  Gly Asn Thr Leu Ile  Val Asn Asn Leu Asn  Gly Leu Tyr 
    1205                 1210                 1215             


Asp Lys  Asp Asn Asp Lys Leu  Lys Lys Leu Ile Asn  Lys Ser Pro 
    1220                 1225                 1230             


Glu Lys  Leu Leu Met Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys 
    1235                 1240                 1245             


Leu Lys  Leu Ile Met Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu 
    1250                 1255                 1260             


Tyr Lys  Tyr Tyr Glu Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser 
    1265                 1270                 1275             


Lys Lys  Asp Asn Gly Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly 
    1280                 1285                 1290             


Asn Lys  Leu Asn Ala His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn 
    1295                 1300                 1305             


Ser Arg  Asn Lys Val Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe 
    1310                 1315                 1320             


Asp Val  Tyr Leu Asp Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys 
    1325                 1330                 1335             


Asn Leu  Asp Val Ile Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser 
    1340                 1345                 1350             


Lys Cys  Tyr Glu Glu Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln 
    1355                 1360                 1365             


Ala Glu  Phe Ile Ala Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile 
    1370                 1375                 1380             


Asn Gly  Glu Leu Tyr Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu 
    1385                 1390                 1395             


Asn Arg  Ile Glu Val Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr 
    1400                 1405                 1410             


Leu Glu  Asn Met Asn Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr 
    1415                 1420                 1425             


Ile Ala  Ser Lys Thr Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile 
    1430                 1435                 1440             


Leu Gly  Asn Leu Tyr Glu Val  Lys Ser Lys Lys His  Pro Gln Ile 
    1445                 1450                 1455             


Ile Lys  Lys Gly Lys Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln 
    1460                 1465                 1470             


Ala Lys  Lys Lys Lys 
    1475             


<210>  21
<211>  1476
<212>  PRT
<213>  artificial sequence

<220>
<223>  SanCas9-KKH-ABE

<400>  21

Met Pro Lys Lys Lys Arg Lys Val Ser Gly Gly Ser Ser Glu Val Glu 
1               5                   10                  15      


Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg 
            20                  25                  30          


Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn 
        35                  40                  45              


Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp 
    50                  55                  60                  


Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val 
65                  70                  75                  80  


Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Leu Glu 
                85                  90                  95      


Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg 
            100                 105                 110         


Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu 
        115                 120                 125             


Met Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr 
    130                 135                 140                 


Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe 
145                 150                 155                 160 


Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser 
                165                 170                 175     


Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro 
            180                 185                 190         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly 
        195                 200                 205             


Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala 
    210                 215                 220                 


Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly 
225                 230                 235                 240 


Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg 
                245                 250                 255     


Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu 
            260                 265                 270         


Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr 
        275                 280                 285             


Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile 
    290                 295                 300                 


His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr 
305                 310                 315                 320 


Gly Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn 
                325                 330                 335     


His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala 
            340                 345                 350         


Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln 
        355                 360                 365             


Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser 
    370                 375                 380                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Lys Arg Asn Tyr Ile Leu Gly Leu 
                405                 410                 415     


Asp Ile Gly Ile Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr 
            420                 425                 430         


Arg Asp Val Ile Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val 
        435                 440                 445             


Glu Asn Asn Glu Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys 
    450                 455                 460                 


Arg Arg Arg Arg His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp 
465                 470                 475                 480 


Tyr Asn Leu Leu Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr 
                485                 490                 495     


Glu Ala Arg Val Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe 
            500                 505                 510         


Ser Ala Ala Leu Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val 
        515                 520                 525             


Asn Glu Val Glu Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln 
    530                 535                 540                 


Ile Ser Arg Asn Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu 
545                 550                 555                 560 


Gln Leu Glu Arg Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn 
                565                 570                 575     


Arg Phe Lys Thr Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys 
            580                 585                 590         


Val Gln Lys Ala Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr 
        595                 600                 605             


Ile Asp Leu Leu Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu 
    610                 615                 620                 


Gly Ser Pro Phe Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu 
625                 630                 635                 640 


Met Gly His Cys Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr 
                645                 650                 655     


Ala Tyr Asn Ala Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu 
            660                 665                 670         


Val Ile Thr Arg Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe 
        675                 680                 685             


Gln Ile Ile Glu Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys 
    690                 695                 700                 


Gln Ile Ala Lys Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr 
705                 710                 715                 720 


Arg Val Thr Ser Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr 
                725                 730                 735     


His Asp Ile Lys Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala 
            740                 745                 750         


Glu Leu Leu Asp Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser 
        755                 760                 765             


Glu Asp Ile Gln Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln 
    770                 775                 780                 


Glu Glu Ile Glu Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His 
785                 790                 795                 800 


Asn Leu Ser Leu Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His 
                805                 810                 815     


Thr Asn Asp Asn Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro 
            820                 825                 830         


Lys Lys Val Asp Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val 
        835                 840                 845             


Asp Asp Phe Ile Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser 
    850                 855                 860                 


Ile Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp 
865                 870                 875                 880 


Ile Ile Ile Glu Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys 
                885                 890                 895     


Met Ile Asn Glu Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile 
            900                 905                 910         


Glu Glu Ile Ile Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile 
        915                 920                 925             


Glu Lys Ile Lys Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser 
    930                 935                 940                 


Leu Glu Ala Ile Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr 
945                 950                 955                 960 


Glu Val Asp His Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe 
                965                 970                 975     


Asn Asn Lys Val Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn 
            980                 985                 990         


Arg Thr Pro Phe Gln Tyr Leu Ser  Ser Ser Asp Ser Lys  Ile Ser Tyr 
        995                 1000                 1005             


Glu Thr  Phe Lys Lys His Ile  Leu Asn Leu Ala Lys  Gly Lys Gly 
    1010                 1015                 1020             


Arg Ile  Ser Lys Thr Lys Lys  Glu Tyr Leu Leu Glu  Glu Arg Asp 
    1025                 1030                 1035             


Ile Asn  Arg Phe Ser Val Gln  Lys Asp Phe Ile Asn  Arg Asn Leu 
    1040                 1045                 1050             


Val Asp  Thr Arg Tyr Ala Thr  Arg Gly Leu Met Asn  Leu Leu Arg 
    1055                 1060                 1065             


Ser Tyr  Phe Arg Val Asn Asn  Leu Asp Val Lys Val  Lys Ser Ile 
    1070                 1075                 1080             


Asn Gly  Gly Phe Thr Ser Phe  Leu Arg Arg Lys Trp  Lys Phe Lys 
    1085                 1090                 1095             


Lys Glu  Arg Asn Lys Gly Tyr  Lys His His Ala Glu  Asp Ala Leu 
    1100                 1105                 1110             


Ile Ile  Ala Asn Ala Asp Phe  Ile Phe Lys Glu Trp  Lys Lys Leu 
    1115                 1120                 1125             


Asp Lys  Ala Lys Lys Val Met  Glu Asn Gln Met Phe  Glu Glu Lys 
    1130                 1135                 1140             


Gln Ala  Glu Ser Met Pro Glu  Ile Glu Thr Glu Gln  Glu Tyr Lys 
    1145                 1150                 1155             


Glu Ile  Phe Ile Thr Pro His  Gln Ile Lys His Ile  Lys Asp Phe 
    1160                 1165                 1170             


Lys Asp  Tyr Lys Tyr Ser His  Arg Val Asp Lys Lys  Pro Asn Arg 
    1175                 1180                 1185             


Lys Leu  Ile Asn Asp Thr Leu  Tyr Ser Thr Arg Lys  Asp Asp Lys 
    1190                 1195                 1200             


Gly Asn  Thr Leu Ile Val Asn  Asn Leu Asn Gly Leu  Tyr Asp Lys 
    1205                 1210                 1215             


Asp Asn  Asp Lys Leu Lys Lys  Leu Ile Asn Lys Ser  Pro Glu Lys 
    1220                 1225                 1230             


Leu Leu  Met Tyr His His Asp  Pro Gln Thr Tyr Gln  Lys Leu Lys 
    1235                 1240                 1245             


Leu Ile  Met Glu Gln Tyr Gly  Asp Glu Lys Asn Pro  Leu Tyr Lys 
    1250                 1255                 1260             


Tyr Tyr  Glu Glu Thr Gly Asn  Tyr Leu Thr Lys Tyr  Ser Lys Lys 
    1265                 1270                 1275             


Asp Asn  Gly Pro Val Ile Lys  Lys Ile Lys Tyr Tyr  Gly Asn Lys 
    1280                 1285                 1290             


Leu Asn  Ala His Leu Asp Ile  Thr Asp Asp Tyr Pro  Asn Ser Arg 
    1295                 1300                 1305             


Asn Lys  Val Val Lys Leu Ser  Leu Lys Pro Tyr Arg  Phe Asp Val 
    1310                 1315                 1320             


Tyr Leu  Asp Asn Gly Val Tyr  Lys Phe Val Thr Val  Lys Asn Leu 
    1325                 1330                 1335             


Asp Val  Ile Lys Lys Glu Asn  Tyr Tyr Glu Val Asn  Ser Lys Cys 
    1340                 1345                 1350             


Tyr Glu  Glu Ala Lys Lys Leu  Lys Lys Ile Ser Asn  Gln Ala Glu 
    1355                 1360                 1365             


Phe Ile  Ala Ser Phe Tyr Lys  Asn Asp Leu Ile Lys  Ile Asn Gly 
    1370                 1375                 1380             


Glu Leu  Tyr Arg Val Ile Gly  Val Asn Asn Asp Leu  Leu Asn Arg 
    1385                 1390                 1395             


Ile Glu  Val Asn Met Ile Asp  Ile Thr Tyr Arg Glu  Tyr Leu Glu 
    1400                 1405                 1410             


Asn Met  Asn Asp Lys Arg Pro  Pro His Ile Ile Lys  Thr Ile Ala 
    1415                 1420                 1425             


Ser Lys  Thr Gln Ser Ile Lys  Lys Tyr Ser Thr Asp  Ile Leu Gly 
    1430                 1435                 1440             


Asn Leu  Tyr Glu Val Lys Ser  Lys Lys His Pro Gln  Ile Ile Lys 
    1445                 1450                 1455             


Lys Gly  Lys Arg Pro Ala Ala  Thr Lys Lys Ala Gly  Gln Ala Lys 
    1460                 1465                 1470             


Lys Lys  Lys 
    1475     


<210>  22
<211>  1790
<212>  PRT
<213>  artificial sequence

<220>
<223>  SpnCas9-VQR-ABE-1

<400>  22

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Leu Lys Gly 
385                 390                 395                 400 


Ile His Gly Val Pro Ala Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp 
                405                 410                 415     


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
            420                 425                 430         


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
        435                 440                 445             


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
    450                 455                 460                 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
465                 470                 475                 480 


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
                485                 490                 495     


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
            500                 505                 510         


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
        515                 520                 525             


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
    530                 535                 540                 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
545                 550                 555                 560 


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
                565                 570                 575     


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
            580                 585                 590         


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
        595                 600                 605             


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
    610                 615                 620                 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
625                 630                 635                 640 


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
                645                 650                 655     


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
            660                 665                 670         


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
        675                 680                 685             


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
    690                 695                 700                 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
705                 710                 715                 720 


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
                725                 730                 735     


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
            740                 745                 750         


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
        755                 760                 765             


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
    770                 775                 780                 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
785                 790                 795                 800 


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
                805                 810                 815     


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
            820                 825                 830         


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
        835                 840                 845             


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
    850                 855                 860                 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
865                 870                 875                 880 


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
                885                 890                 895     


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
            900                 905                 910         


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
        915                 920                 925             


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
    930                 935                 940                 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
945                 950                 955                 960 


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
                965                 970                 975     


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
            980                 985                 990         


Phe Asn Ala Ser Leu Gly Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys 
        995                 1000                 1005             


Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu 
    1010                 1015                 1020             


Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile 
    1025                 1030                 1035             


Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val 
    1040                 1045                 1050             


Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu 
    1055                 1060                 1065             


Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys 
    1070                 1075                 1080             


Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn 
    1085                 1090                 1095             


Phe Met  Gln Leu Ile His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp 
    1100                 1105                 1110             


Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly Asp Ser  Leu His Glu 
    1115                 1120                 1125             


His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile 
    1130                 1135                 1140             


Leu Gln  Thr Val Lys Val Val  Asp Glu Leu Val Lys  Val Met Gly 
    1145                 1150                 1155             


Arg His  Lys Pro Glu Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn 
    1160                 1165                 1170             


Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys 
    1175                 1180                 1185             


Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys 
    1190                 1195                 1200             


Glu His  Pro Val Glu Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr 
    1205                 1210                 1215             


Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu 
    1220                 1225                 1230             


Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp Val Asp  His Ile Val 
    1235                 1240                 1245             


Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
    1250                 1255                 1260             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1265                 1270                 1275             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1280                 1285                 1290             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1295                 1300                 1305             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1310                 1315                 1320             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1325                 1330                 1335             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1340                 1345                 1350             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1355                 1360                 1365             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1370                 1375                 1380             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1385                 1390                 1395             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1400                 1405                 1410             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1415                 1420                 1425             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1430                 1435                 1440             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1445                 1450                 1455             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1460                 1465                 1470             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1475                 1480                 1485             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1490                 1495                 1500             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1505                 1510                 1515             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1520                 1525                 1530             


Pro Lys  Lys Tyr Gly Gly Phe  Val Ser Pro Thr Val  Ala Tyr Ser 
    1535                 1540                 1545             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1550                 1555                 1560             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1565                 1570                 1575             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1580                 1585                 1590             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1595                 1600                 1605             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1610                 1615                 1620             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1625                 1630                 1635             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1640                 1645                 1650             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1655                 1660                 1665             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1670                 1675                 1680             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1685                 1690                 1695             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1700                 1705                 1710             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1715                 1720                 1725             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Gln Tyr Arg 
    1730                 1735                 1740             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1745                 1750                 1755             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1760                 1765                 1770             


Asp Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1775                 1780                 1785             


Lys Lys  
    1790 


<210>  23
<211>  1790
<212>  PRT
<213>  artificial sequence

<220>
<223>  SpnCas9-VRER-ABE-1

<400>  23

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Leu Lys Gly 
385                 390                 395                 400 


Ile His Gly Val Pro Ala Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp 
                405                 410                 415     


Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys 
            420                 425                 430         


Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser 
        435                 440                 445             


Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr 
    450                 455                 460                 


Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg 
465                 470                 475                 480 


Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met 
                485                 490                 495     


Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu 
            500                 505                 510         


Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile 
        515                 520                 525             


Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu 
    530                 535                 540                 


Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile 
545                 550                 555                 560 


Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile 
                565                 570                 575     


Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile 
            580                 585                 590         


Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn 
        595                 600                 605             


Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys 
    610                 615                 620                 


Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys 
625                 630                 635                 640 


Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro 
                645                 650                 655     


Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu 
            660                 665                 670         


Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile 
        675                 680                 685             


Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp 
    690                 695                 700                 


Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys 
705                 710                 715                 720 


Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln 
                725                 730                 735     


Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys 
            740                 745                 750         


Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr 
        755                 760                 765             


Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro 
    770                 775                 780                 


Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn 
785                 790                 795                 800 


Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile 
                805                 810                 815     


Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln 
            820                 825                 830         


Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys 
        835                 840                 845             


Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly 
    850                 855                 860                 


Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr 
865                 870                 875                 880 


Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser 
                885                 890                 895     


Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys 
            900                 905                 910         


Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn 
        915                 920                 925             


Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala 
    930                 935                 940                 


Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys 
945                 950                 955                 960 


Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys 
                965                 970                 975     


Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg 
            980                 985                 990         


Phe Asn Ala Ser Leu Gly Thr Tyr  His Asp Leu Leu Lys  Ile Ile Lys 
        995                 1000                 1005             


Asp Lys  Asp Phe Leu Asp Asn  Glu Glu Asn Glu Asp  Ile Leu Glu 
    1010                 1015                 1020             


Asp Ile  Val Leu Thr Leu Thr  Leu Phe Glu Asp Arg  Glu Met Ile 
    1025                 1030                 1035             


Glu Glu  Arg Leu Lys Thr Tyr  Ala His Leu Phe Asp  Asp Lys Val 
    1040                 1045                 1050             


Met Lys  Gln Leu Lys Arg Arg  Arg Tyr Thr Gly Trp  Gly Arg Leu 
    1055                 1060                 1065             


Ser Arg  Lys Leu Ile Asn Gly  Ile Arg Asp Lys Gln  Ser Gly Lys 
    1070                 1075                 1080             


Thr Ile  Leu Asp Phe Leu Lys  Ser Asp Gly Phe Ala  Asn Arg Asn 
    1085                 1090                 1095             


Phe Met  Gln Leu Ile His Asp  Asp Ser Leu Thr Phe  Lys Glu Asp 
    1100                 1105                 1110             


Ile Gln  Lys Ala Gln Val Ser  Gly Gln Gly Asp Ser  Leu His Glu 
    1115                 1120                 1125             


His Ile  Ala Asn Leu Ala Gly  Ser Pro Ala Ile Lys  Lys Gly Ile 
    1130                 1135                 1140             


Leu Gln  Thr Val Lys Val Val  Asp Glu Leu Val Lys  Val Met Gly 
    1145                 1150                 1155             


Arg His  Lys Pro Glu Asn Ile  Val Ile Glu Met Ala  Arg Glu Asn 
    1160                 1165                 1170             


Gln Thr  Thr Gln Lys Gly Gln  Lys Asn Ser Arg Glu  Arg Met Lys 
    1175                 1180                 1185             


Arg Ile  Glu Glu Gly Ile Lys  Glu Leu Gly Ser Gln  Ile Leu Lys 
    1190                 1195                 1200             


Glu His  Pro Val Glu Asn Thr  Gln Leu Gln Asn Glu  Lys Leu Tyr 
    1205                 1210                 1215             


Leu Tyr  Tyr Leu Gln Asn Gly  Arg Asp Met Tyr Val  Asp Gln Glu 
    1220                 1225                 1230             


Leu Asp  Ile Asn Arg Leu Ser  Asp Tyr Asp Val Asp  His Ile Val 
    1235                 1240                 1245             


Pro Gln  Ser Phe Leu Lys Asp  Asp Ser Ile Asp Asn  Lys Val Leu 
    1250                 1255                 1260             


Thr Arg  Ser Asp Lys Asn Arg  Gly Lys Ser Asp Asn  Val Pro Ser 
    1265                 1270                 1275             


Glu Glu  Val Val Lys Lys Met  Lys Asn Tyr Trp Arg  Gln Leu Leu 
    1280                 1285                 1290             


Asn Ala  Lys Leu Ile Thr Gln  Arg Lys Phe Asp Asn  Leu Thr Lys 
    1295                 1300                 1305             


Ala Glu  Arg Gly Gly Leu Ser  Glu Leu Asp Lys Ala  Gly Phe Ile 
    1310                 1315                 1320             


Lys Arg  Gln Leu Val Glu Thr  Arg Gln Ile Thr Lys  His Val Ala 
    1325                 1330                 1335             


Gln Ile  Leu Asp Ser Arg Met  Asn Thr Lys Tyr Asp  Glu Asn Asp 
    1340                 1345                 1350             


Lys Leu  Ile Arg Glu Val Lys  Val Ile Thr Leu Lys  Ser Lys Leu 
    1355                 1360                 1365             


Val Ser  Asp Phe Arg Lys Asp  Phe Gln Phe Tyr Lys  Val Arg Glu 
    1370                 1375                 1380             


Ile Asn  Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
    1385                 1390                 1395             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1400                 1405                 1410             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1415                 1420                 1425             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1430                 1435                 1440             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1445                 1450                 1455             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1460                 1465                 1470             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1475                 1480                 1485             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1490                 1495                 1500             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1505                 1510                 1515             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1520                 1525                 1530             


Pro Lys  Lys Tyr Gly Gly Phe  Val Ser Pro Thr Val  Ala Tyr Ser 
    1535                 1540                 1545             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1550                 1555                 1560             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1565                 1570                 1575             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1580                 1585                 1590             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1595                 1600                 1605             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1610                 1615                 1620             


Arg Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1625                 1630                 1635             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1640                 1645                 1650             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1655                 1660                 1665             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1670                 1675                 1680             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1685                 1690                 1695             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1700                 1705                 1710             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1715                 1720                 1725             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Glu Tyr Arg 
    1730                 1735                 1740             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1745                 1750                 1755             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1760                 1765                 1770             


Asp Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1775                 1780                 1785             


Lys Lys  
    1790 


<210>  24
<211>  809
<212>  PRT
<213>  artificial sequence

<220>
<223>  SanCas9-ABE-1

<400>  24

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Leu Lys Met 
385                 390                 395                 400 


Pro Lys Lys Lys Arg Lys Val Ser Gly Gly Ser Ser Glu Val Glu Phe 
                405                 410                 415     


Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala 
            420                 425                 430         


Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn Asn 
        435                 440                 445             


Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp Pro 
    450                 455                 460                 


Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met 
465                 470                 475                 480 


Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Leu Glu Pro 
                485                 490                 495     


Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val 
            500                 505                 510         


Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu Met 
        515                 520                 525             


Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu 
    530                 535                 540                 


Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe Arg 
545                 550                 555                 560 


Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser Thr 
                565                 570                 575     


Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly 
            580                 585                 590         


Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly 
        595                 600                 605             


Ser Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
    610                 615                 620                 


Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly Ala 
625                 630                 635                 640 


Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Ala 
                645                 650                 655     


Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
            660                 665                 670         


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
        675                 680                 685             


Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
    690                 695                 700                 


Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr Gly 
705                 710                 715                 720 


Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn His 
                725                 730                 735     


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
            740                 745                 750         


Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln Lys 
        755                 760                 765             


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
    770                 775                 780                 


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
785                 790                 795                 800 


Gly Gly Ser Ser Gly Gly Ser Leu Lys 
                805                 


<210>  25
<211>  1465
<212>  PRT
<213>  artificial sequence

<220>
<223>  SanCas9-KKH-ABE-1

<400>  25

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Lys Arg Asn 
385                 390                 395                 400 


Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly Tyr Gly Ile 
                405                 410                 415     


Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly Val Arg Leu Phe 
            420                 425                 430         


Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser Lys Arg Gly 
        435                 440                 445             


Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile Gln Arg Val Lys 
    450                 455                 460                 


Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His Ser Glu Leu Ser 
465                 470                 475                 480 


Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser Gln Lys Leu 
                485                 490                 495     


Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu Ala Lys Arg Arg 
            500                 505                 510         


Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr Gly Asn Glu Leu 
        515                 520                 525             


Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu Glu Glu Lys 
    530                 535                 540                 


Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp Gly Glu Val 
545                 550                 555                 560 


Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val Lys Glu Ala 
                565                 570                 575     


Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln Leu Asp Gln Ser 
            580                 585                 590         


Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg Thr Tyr Tyr 
        595                 600                 605             


Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp Ile Lys Glu 
    610                 615                 620                 


Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe Pro Glu Glu Leu 
625                 630                 635                 640 


Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn Ala Leu Asn 
                645                 650                 655     


Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn Glu Lys Leu Glu 
            660                 665                 670         


Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe Lys Gln Lys Lys 
        675                 680                 685             


Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu Val Asn Glu Glu 
    690                 695                 700                 


Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro Glu Phe Thr 
705                 710                 715                 720 


Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr Ala Arg Lys Glu 
                725                 730                 735     


Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys Ile Leu Thr 
            740                 745                 750         


Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr Asn Leu Asn 
        755                 760                 765             


Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn Leu Lys Gly 
    770                 775                 780                 


Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile Asn Leu Ile Leu 
785                 790                 795                 800 


Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala Ile Phe Asn Arg 
                805                 810                 815     


Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln Gln Lys Glu Ile 
            820                 825                 830         


Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro Val Val Lys Arg 
        835                 840                 845             


Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile Ile Lys Lys Tyr 
    850                 855                 860                 


Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu Lys Asn Ser 
865                 870                 875                 880 


Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys Arg Asn Arg Gln 
                885                 890                 895     


Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly Lys Glu Asn 
            900                 905                 910         


Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp Met Gln Glu Gly 
        915                 920                 925             


Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp Leu Leu Asn 
    930                 935                 940                 


Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro Arg Ser Val Ser 
945                 950                 955                 960 


Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys Gln Glu Glu Asn 
                965                 970                 975     


Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu Ser Ser Ser Asp 
            980                 985                 990         


Ser Lys Ile Ser Tyr Glu Thr Phe  Lys Lys His Ile Leu  Asn Leu Ala 
        995                 1000                 1005             


Lys Gly  Lys Gly Arg Ile Ser  Lys Thr Lys Lys Glu  Tyr Leu Leu 
    1010                 1015                 1020             


Glu Glu  Arg Asp Ile Asn Arg  Phe Ser Val Gln Lys  Asp Phe Ile 
    1025                 1030                 1035             


Asn Arg  Asn Leu Val Asp Thr  Arg Tyr Ala Thr Arg  Gly Leu Met 
    1040                 1045                 1050             


Asn Leu  Leu Arg Ser Tyr Phe  Arg Val Asn Asn Leu  Asp Val Lys 
    1055                 1060                 1065             


Val Lys  Ser Ile Asn Gly Gly  Phe Thr Ser Phe Leu  Arg Arg Lys 
    1070                 1075                 1080             


Trp Lys  Phe Lys Lys Glu Arg  Asn Lys Gly Tyr Lys  His His Ala 
    1085                 1090                 1095             


Glu Asp  Ala Leu Ile Ile Ala  Asn Ala Asp Phe Ile  Phe Lys Glu 
    1100                 1105                 1110             


Trp Lys  Lys Leu Asp Lys Ala  Lys Lys Val Met Glu  Asn Gln Met 
    1115                 1120                 1125             


Phe Glu  Glu Lys Gln Ala Glu  Ser Met Pro Glu Ile  Glu Thr Glu 
    1130                 1135                 1140             


Gln Glu  Tyr Lys Glu Ile Phe  Ile Thr Pro His Gln  Ile Lys His 
    1145                 1150                 1155             


Ile Lys  Asp Phe Lys Asp Tyr  Lys Tyr Ser His Arg  Val Asp Lys 
    1160                 1165                 1170             


Lys Pro  Asn Arg Lys Leu Ile  Asn Asp Thr Leu Tyr  Ser Thr Arg 
    1175                 1180                 1185             


Lys Asp  Asp Lys Gly Asn Thr  Leu Ile Val Asn Asn  Leu Asn Gly 
    1190                 1195                 1200             


Leu Tyr  Asp Lys Asp Asn Asp  Lys Leu Lys Lys Leu  Ile Asn Lys 
    1205                 1210                 1215             


Ser Pro  Glu Lys Leu Leu Met  Tyr His His Asp Pro  Gln Thr Tyr 
    1220                 1225                 1230             


Gln Lys  Leu Lys Leu Ile Met  Glu Gln Tyr Gly Asp  Glu Lys Asn 
    1235                 1240                 1245             


Pro Leu  Tyr Lys Tyr Tyr Glu  Glu Thr Gly Asn Tyr  Leu Thr Lys 
    1250                 1255                 1260             


Tyr Ser  Lys Lys Asp Asn Gly  Pro Val Ile Lys Lys  Ile Lys Tyr 
    1265                 1270                 1275             


Tyr Gly  Asn Lys Leu Asn Ala  His Leu Asp Ile Thr  Asp Asp Tyr 
    1280                 1285                 1290             


Pro Asn  Ser Arg Asn Lys Val  Val Lys Leu Ser Leu  Lys Pro Tyr 
    1295                 1300                 1305             


Arg Phe  Asp Val Tyr Leu Asp  Asn Gly Val Tyr Lys  Phe Val Thr 
    1310                 1315                 1320             


Val Lys  Asn Leu Asp Val Ile  Lys Lys Glu Asn Tyr  Tyr Glu Val 
    1325                 1330                 1335             


Asn Ser  Lys Cys Tyr Glu Glu  Ala Lys Lys Leu Lys  Lys Ile Ser 
    1340                 1345                 1350             


Asn Gln  Ala Glu Phe Ile Ala  Ser Phe Tyr Lys Asn  Asp Leu Ile 
    1355                 1360                 1365             


Lys Ile  Asn Gly Glu Leu Tyr  Arg Val Ile Gly Val  Asn Asn Asp 
    1370                 1375                 1380             


Leu Leu  Asn Arg Ile Glu Val  Asn Met Ile Asp Ile  Thr Tyr Arg 
    1385                 1390                 1395             


Glu Tyr  Leu Glu Asn Met Asn  Asp Lys Arg Pro Pro  His Ile Ile 
    1400                 1405                 1410             


Lys Thr  Ile Ala Ser Lys Thr  Gln Ser Ile Lys Lys  Tyr Ser Thr 
    1415                 1420                 1425             


Asp Ile  Leu Gly Asn Leu Tyr  Glu Val Lys Ser Lys  Lys His Pro 
    1430                 1435                 1440             


Gln Ile  Ile Lys Lys Gly Lys  Arg Pro Ala Ala Thr  Lys Lys Ala 
    1445                 1450                 1455             


Gly Gln  Ala Lys Lys Lys Lys  
    1460                 1465 


<210>  26
<211>  5382
<212>  DNA
<213>  artificial sequence

<220>
<223>  PABE-1 DNA

<400>  26
atgccaaaaa agaagagaaa ggtttcaggc ggctcctccg aggtggagtt ctctcacgag       60

tattggatga ggcacgctct tacacttgct aagagagctt gggacgaaag agaagtgcca      120

gttggcgccg ttcttgtgca taataatagg gtgatcggcg agggttggaa tagaccaatt      180

ggaaggcatg atccaacagc tcacgcagag attatggctc tcagacaagg cggcctcgtt      240

atgcagaact acaggctcat tgacgctaca ctctacgtga cactcgaacc ttgcgttatg      300

tgcgccggag ctatgattca ttctaggatt ggcagggtcg tgtttggagc tagggacgct      360

aaaacaggag ccgccggatc tcttatggac gtgttgcatc atccaggcat gaaccatagg      420

gtggagatta cagagggcat tcttgcagac gagtgcgctg ctcttctttc cgatttcttc      480

aggatgagaa ggcaggagat taaggcccag aagaaggctc agtcttctac agatagcgga      540

ggatcttccg gaggatctag cggctccgag acaccaggaa catccgaaag cgctacacca      600

gaatctagcg gaggctcttc cggaggatct tctgaagtgg agttctccca cgagtattgg      660

atgaggcacg ctcttacact tgctaaaagg cctagggacg aaagggaagt tccagttgga      720

gctgttctcg tgctcaataa cagggtgatt ggcgacggtt ggaatagagc cattggactc      780

catgatccaa cagctcacgc agagattatg gctcttagac aaggcggcct cgttatgcag      840

aattacagac tcatcgacgc cacactctac gttaccttcg aaccttgcgt tatgtgcgcc      900

ggagctatga tccattctag gattggcagg gtcgtgttcg gcgttagaaa cgctaagaca      960

ggagctgcag gctctcttat ggacgttctt cattacccag gcatgaatca tagagtggag     1020

atcacagaag gcattcttgc agacgagtgc gcagctctcc tttgctattt cttcaggatg     1080

ccgaggcaag ttttcaacgc tcagaagaag gcccagtctt ctacagattc cggcggatct     1140

tctggaggat ctagcggctc cgagacacca ggaacatccg aatccgctac accagagtct     1200

tctggaggat ctagcggagg atctcttaag gacaagaagt actcgatcgg cctcgccatt     1260

gggactaact ctgttggctg ggccgtgatc accgacgagt acaaggtgcc ctcaaagaag     1320

ttcaaggtcc tgggcaacac cgatcggcat tccatcaaga agaatctcat tggcgctctc     1380

ctgttcgaca gcggcgagac ggctgaggct acgcggctca agcgcaccgc ccgcaggcgg     1440

tacacgcgca ggaagaatcg catctgctac ctgcaggaga ttttctccaa cgagatggcg     1500

aaggttgacg attctttctt ccacaggctg gaggagtcat tcctcgtgga ggaggataag     1560

aagcacgagc ggcatccaat cttcggcaac attgtcgacg aggttgccta ccacgagaag     1620

taccctacga tctaccatct gcggaagaag ctcgtggact ccacagataa ggcggacctc     1680

cgcctgatct acctcgctct ggcccacatg attaagttca ggggccattt cctgatcgag     1740

ggggatctca acccggacaa tagcgatgtt gacaagctgt tcatccagct cgtgcagacg     1800

tacaaccagc tcttcgagga gaaccccatt aatgcgtcag gcgtcgacgc gaaggctatc     1860

ctgtccgcta ggctctcgaa gtctcggcgc ctcgagaacc tgatcgccca gctgccgggc     1920

gagaagaaga acggcctgtt cgggaatctc attgcgctca gcctggggct cacgcccaac     1980

ttcaagtcga atttcgatct cgctgaggac gccaagctgc agctctccaa ggacacatac     2040

gacgatgacc tggataacct cctggcccag atcggcgatc agtacgcgga cctgttcctc     2100

gctgccaaga atctgtcgga cgccatcctc ctgtctgata ttctcagggt gaacaccgag     2160

attacgaagg ctccgctctc agcctccatg atcaagcgct acgacgagca ccatcaggat     2220

ctgaccctcc tgaaggcgct ggtcaggcag cagctccccg agaagtacaa ggagatcttc     2280

ttcgatcagt cgaagaacgg ctacgctggg tacattgacg gcggggcctc tcaggaggag     2340

ttctacaagt tcatcaagcc gattctggag aagatggacg gcacggagga gctgctggtg     2400

aagctcaatc gcgaggacct cctgaggaag cagcggacat tcgataacgg cagcatccca     2460

caccagattc atctcgggga gctgcacgct atcctgagga ggcaggagga cttctaccct     2520

ttcctcaagg ataaccgcga gaagatcgag aagattctga ctttcaggat cccgtactac     2580

gtcggcccac tcgctagggg caactcccgc ttcgcttgga tgacccgcaa gtcagaggag     2640

acgatcacgc cgtggaactt cgaggaggtg gtcgacaagg gcgctagcgc tcagtcgttc     2700

atcgagagga tgacgaattt cgacaagaac ctgccaaatg agaaggtgct ccctaagcac     2760

tcgctcctgt acgagtactt cacagtctac aacgagctga ctaaggtgaa gtatgtgacc     2820

gagggcatga ggaagccggc tttcctgtct ggggagcaga agaaggccat cgtggacctc     2880

ctgttcaaga ccaaccggaa ggtcacggtt aagcagctca aggaggacta cttcaagaag     2940

attgagtgct tcgattcggt cgagatctct ggcgttgagg accgcttcaa cgcctccctg     3000

gggacctacc acgatctcct gaagatcatt aaggataagg acttcctgga caacgaggag     3060

aatgaggata tcctcgagga cattgtgctg acactcactc tgttcgagga ccgggagatg     3120

atcgaggagc gcctgaagac ttacgcccat ctcttcgatg acaaggtcat gaagcagctc     3180

aagaggagga ggtacaccgg ctgggggagg ctgagcagga agctcatcaa cggcattcgg     3240

gacaagcagt ccgggaagac gatcctcgac ttcctgaaga gcgatggctt cgcgaaccgc     3300

aatttcatgc agctgattca cgatgacagc ctcacattca aggaggatat ccagaaggct     3360

caggtgagcg gccaggggga ctcgctgcac gagcatatcg cgaacctcgc tggctcgcca     3420

gctatcaaga aggggattct gcagaccgtg aaggttgtgg acgagctggt gaaggtcatg     3480

ggcaggcaca agcctgagaa catcgtcatt gagatggccc gggagaatca gaccacgcag     3540

aagggccaga agaactcacg cgagaggatg aagaggatcg aggagggcat taaggagctg     3600

gggtcccaga tcctcaagga gcacccggtg gagaacacgc agctgcagaa tgagaagctc     3660

tacctgtact acctccagaa tggccgcgat atgtatgtgg accaggagct ggatattaac     3720

aggctcagcg attacgacgt cgatcatatc gttccacagt cattcctgaa ggatgactcc     3780

attgacaaca aggtcctcac caggtcggac aagaaccggg gcaagtctga taatgttcct     3840

tcagaggagg tcgttaagaa gatgaagaac tactggcgcc agctcctgaa tgccaagctg     3900

atcacgcagc ggaagttcga taacctcaca aaggctgaga ggggcgggct ctctgagctg     3960

gacaaggcgg gcttcatcaa gaggcagctg gtcgagacac ggcagatcac taagcacgtt     4020

gcgcagattc tcgactcacg gatgaacact aagtacgatg agaatgacaa gctgatccgc     4080

gaggtgaagg tcatcaccct gaagtcaaag ctcgtctccg acttcaggaa ggatttccag     4140

ttctacaagg ttcgggagat caacaattac caccatgccc atgacgcgta cctgaacgcg     4200

gtggtcggca cagctctgat caagaagtac ccaaagctcg agagcgagtt cgtgtacggg     4260

gactacaagg tttacgatgt gaggaagatg atcgccaagt cggagcagga gattggcaag     4320

gctaccgcca agtacttctt ctactctaac attatgaatt tcttcaagac agagatcact     4380

ctggccaatg gcgagatccg gaagcgcccc ctcatcgaga cgaacggcga gacgggggag     4440

atcgtgtggg acaagggcag ggatttcgcg accgtcagga aggttctctc catgccacaa     4500

gtgaatatcg tcaagaagac agaggtccag actggcgggt tctctaagga gtcaattctg     4560

cctaagcgga acagcgacaa gctcatcgcc cgcaagaagg actgggatcc gaagaagtac     4620

ggcgggttcg acagccccac tgtggcctac tcggtcctgg ttgtggcgaa ggttgagaag     4680

ggcaagtcca agaagctcaa gagcgtgaag gagctgctgg ggatcacgat tatggagcgc     4740

tccagcttcg agaagaaccc gatcgatttc ctggaggcga agggctacaa ggaggtgaag     4800

aaggacctga tcattaagct ccccaagtac tcactcttcg agctggagaa cggcaggaag     4860

cggatgctgg cttccgctgg cgagctgcag aaggggaacg agctggctct gccgtccaag     4920

tatgtgaact tcctctacct ggcctcccac tacgagaagc tcaagggcag ccccgaggac     4980

aacgagcaga agcagctgtt cgtcgagcag cacaagcatt acctcgacga gatcattgag     5040

cagatttccg agttctccaa gcgcgtgatc ctggccgacg cgaatctgga taaggtcctc     5100

tccgcgtaca acaagcaccg cgacaagcca atcagggagc aggctgagaa tatcattcat     5160

ctcttcaccc tgacgaacct cggcgcccct gctgctttca agtacttcga cacaactatc     5220

gatcgcaaga ggtacacaag cactaaggag gtcctggacg cgaccctcat ccaccagtcg     5280

attaccggcc tctacgagac gcgcatcgac ctgtctcagc tcgggggcga caagcggcca     5340

gcggcgacga agaaggcggg gcaggcgaag aagaagaagt ag                        5382


<210>  27
<211>  5349
<212>  DNA
<213>  artificial sequence

<220>
<223>  PABE-2

<400>  27
atgtccgagg tggagttctc tcacgagtat tggatgaggc acgctcttac acttgctaag       60

agagcttggg acgaaagaga agtcccagtt ggcgccgttc ttgtgcataa taatagggtg      120

atcggcgagg gttggaatag accaattgga aggcatgatc caacagctca cgcagacatt      180

atggctctca gacaaggcgg cctcgttatg cagaactaca ggctcattga cgctacactc      240

tacgtgacac tcgaaccttg cgttatgtgc gccggagcta tgattcattc taggattggc      300

agggtcgtgt ttggagctag ggacgctaaa acaggagccg ccggatctct tatggacgtg      360

ttgcatcatc caggcatgaa ccatagggtg cagattacag agggcattct tgcagacgag      420

tgcgctcctc ttctttccga tttcttcagg atgagaaggc aggagattaa ggcccagaag      480

aaggctcagt cttctacaga tagcggagca tcttccggag catctagcgg ctccgagaca      540

ccaggaacat ccgaaagcgc tacaccagaa tctagccgag gctcttccgg aggatcttct      600

gaagtggagt tctcccacga gtattggatg acgcaccctc ttacacttgc taaaagggct      660

agggacgaaa gggaagttcc agttggagct gttctcgtgc tcaataacag ggtgattggc      720

gagggttgga atagagccat tggactccat gatccaacag ctcacgcaga gattatggct      780

cttagacaag gcggcctcgt tatgcagaat tacagactca tcgacgccac actctacgtt      840

accttcgaac cttgcgttat gtgcgccgga gctatgatcc attctaggat tggcagggtc      900

gtgttcggcg ttagaaacgc taagacagga gctgcaggct ctcttatgga cgttcttcat      960

tacccaggca tgaatcatag agtggagatc acagaaggca ttcttgcaga cgagtgcgca     1020

gctctccttt gctatttctt caggatgccg aggcaagttt tcaacgctca gaagaaggcc     1080

cagtcttcta cagattccgg cggatcttct ggaggatcta gcggctccga gacaccagga     1140

acatrcgaat ccgctacacc agagtcttct ggaggatcta gcggaggatc tcttaaggac     1200

aagaagtact cgatcggcct cgccattggg actaactctg ttggctgggc cgtgatcacc     1260

gacgagtaca aggtgccctc aaagaagttc aaggtcctgg gcaacaccga tcggcattcc     1320

atcaagaaga atctcattgg cgctctcctg ttcgacagcg gcgagacggc tgaggctacg     1380

cggctcaagc gcaccgcccg caggcggtac acgcgcagga agaatcgcat ctgctacctg     1440

caggagattt tctccaacga gatggcgaag gttgacgatt ctttcttcca caggctggag     1500

gagtcattcc tcgtggagga ggataagaag cacgagcggc atccaatctt cggcaacatt     1560

gtcgacgagg ttgcctacca cgagaagtac cctacgatct accatctgcg gaagaagctc     1620

gtggactcca cagataaggc ggacctccgc ctgatctacc tcgctctggc ccacatgatt     1680

aagttcaggg gccatttcct gatcgagggg gatctcaacc cggacaatag cgatgttgac     1740

aagctgttca tccagctcgt gcagacgtac aaccagctct tcgaggagaa ccccattaat     1800

gcgtcaggcg tcgacgcgaa ggctatcctg tccgctaggc tctcgaagtc tcggcgcctc     1860

gagaacctga tcgcccagct gccgggcgag aagaagaacg gcctgttcgg gaatctcatt     1920

gcgctcagcc tggggctcac gcccaacttc aagtcgaatt tcgatctcgc tgaggacgcc     1980

aagctgcagc tctccaagga cacatacgac gatgacctgg ataacctcct ggcccagatc     2040

ggcgatcagt acgcggacct gttcctcgct gccaagaatc tgtcggacgc catcctcctg     2100

tctgatattc tcagggtgaa caccgagatt acgaaggctc cgctctcagc ctccatgatc     2160

aagcgctacg acgagcacca tcaggatctg accctcctga aggcgctggt caggcagcag     2220

ctccccgaga agtacaagga gatcttcttc gatcagtcga agaacggcta cgctgggtac     2280

attgacggcg gggcctctca ggaggagttc tacaagttca tcaagccgat tctggagaag     2340

atggacggca cggaggagct gctggtgaag ctcaatcgcg aggacctcct gaggaagcag     2400

cggacattcg ataacggcag catcccacac cagattcatc tcggggagct gcacgctatc     2460

ctgaggaggc aggaggactt ctaccctttc ctcaaggata accgcgagaa gatcgagaag     2520

attctgactt tcaggatccc gtactacgtc ggcccactcg ctaggggcaa ctcccgcttc     2580

gcttggatga cccgcaagtc agaggagacg atcacgccgt ggaacttcga ggaggtggtc     2640

gacaagggcg ctagcgctca gtcgttcatc gagaggatga cgaatttcga caagaacctg     2700

ccaaatgaga aggtgctccc taagcactcg ctcctgtacg agtacttcac agtctacaac     2760

gagctgacta aggtgaagta tgtgaccgag ggcatgagga agccggcttt cctgtctggg     2820

gagcagaaga aggccatcgt ggacctcctg ttcaagacca accggaaggt cacggttaag     2880

cagctcaagg aggactactt caagaagatt gagtgcttcg attcggtcga gatctctggc     2940

gttgaggacc gcttcaacgc ctccctgggg acctaccacg atctcctgaa gatcattaag     3000

gataaggact tcctggacaa cgaggagaat gaggatatcc tcgaggacat tgtgctgaca     3060

ctcactctgt tcgaggaccg ggagatgatc gaggagcgcc tgaagactta cgcccatctc     3120

ttcgatgaca aggtcatgaa gcagctcaag aggaggaggt acaccggctg ggggaggctg     3180

agcaggaagc tcatcaacgg cattcgggac aagcagtccg ggaagacgat cctcgacttc     3240

ctgaagagcg atggcttcgc gaaccgcaat ttcatgcagc tgattcacga tgacagcctc     3300

acattcaagg aggatatcca gaaggctcag gtgagcggcc agggggactc gctgcacgag     3360

catatcgcga acctcgctgg ctcgccagct atcaagaagg ggattctgca gaccgtgaag     3420

gttgtggacg agctggtgaa ggtcatgggc aggcacaagc ctgagaacat cgtcattgag     3480

atggcccggg agaatcagac cacgcagaag ggccagaaga actcacgcga gaggatgaag     3540

aggatcgagg agggcattaa ggagctgggg tcccagatcc tcaaggagca cccggtggag     3600

aacacgcagc tgcagaatga gaagctctac ctgtactacc tccagaatgg ccgcgatatg     3660

tatgtggacc aggagctgga tattaacagg ctcagcgatt acgacgtcga tcatatcgtt     3720

ccacagtcat tcctgaagga tgactccatt gacaacaagg tcctcaccag gtcggacaag     3780

aaccggggca agtctgataa tgttccttca gaggaggtcg ttaagaagat gaagaactac     3840

tggcgccagc tcctgaatgc caagctgatc acgcagcgga agttcgataa cctcacaaag     3900

gctgagaggg gcgggctctc tgagctggac aaggcgggct tcatcaagag gcagctggtc     3960

gagacacggc agatcactaa gcacgttgcg cagattctcg actcacggat gaacactaag     4020

tacgatgaga atgacaagct gatccgcgag gtgaaggtca tcaccctgaa gtcaaagctc     4080

gtctccgact tcaggaagga tttccagttc tacaaggttc gggagatcaa caattaccac     4140

catgcccatg acgcgtacct gaacgcggtg gtcggcacag ctctgatcaa gaagtaccca     4200

aagctcgaga gcgagttcgt gtacggggac tacaaggttt acgatgtgag gaagatgatc     4260

gccaagtcgg agcaggagat tggcaaggct accgccaagt acttcttcta ctctaacatt     4320

atgaatttct tcaagacaga gatcactctg gccaatggcg agatccggaa gcgccccctc     4380

atcgagacga acggcgagac gggggagatc gtgtgggaca agggcaggga tttcgcgacc     4440

gtcaggaagg ttctctccat gccacaagtg aatatcgtca agaagacaga ggtccagact     4500

ggcgggttct ctaaggagtc aattctgcct aagcggaaca gcgacaagct catcgcccgc     4560

aagaaggact gggatccgaa gaagtacggc gggttcgaca gccccactgt ggcctactcg     4620

gtcctggttg tggcgaaggt tgagaagggc aagtccaaga agctcaagag cgtgaaggag     4680

ctgctgggga tcacgattat ggagcgctcc agcttcgaga agaacccgat cgatttcctg     4740

gaggcgaagg gctacaagga ggtgaagaag gacctgatca ttaagctccc caagtactca     4800

ctcttcgagc tggagaacgg caggaagcgg atgctggctt ccgctggcga gctgcagaag     4860

gggaacgagc tggctctgcc gtccaagtat gtgaacttcc tctacctggc ctcccactac     4920

gagaagctca agggcagccc cgaggacaac gagcagaagc agctgttcgt cgagcagcac     4980

aagcattacc tcgacgagat cattgagcag atttccgagt tctccaagcg cgtgatcctg     5040

gccgacgcga atctggataa ggtcctctcc gcgtacaaca agcaccgcga caagccaatc     5100

agggagcagg ctgagaatat cattcatctc ttcaccctga cgaacctcgg cgcccctgct     5160

gctttcaagt acttcgacac aactatcgat cgcaagaggt acacaagcac taaggaggtc     5220

ctggacgcga ccctcatcca ccagtcgatt accggcctct acgagacgcg catcgacctg     5280

tctcagctcg ggggcgacaa gcggccagcg gcgacgaaga aggcggggca ggcgaagaag     5340

aagaagtag                                                             5349


<210>  28
<211>  5382
<212>  DNA
<213>  artificial sequence

<220>
<223>  PABE-3

<400>  28
atgtccgagg tggagttctc tcacgagtat tggatgaggc acgctcttac acttgctaag       60

agagcttggg acgaaagaga agtgccagtt ggcgccgttc ttgtgcataa taatagggtg      120

atcggcgagg gttggaatag accaattgga aggcatgatc caacagctca cgcagagatt      180

atggctctca gacaaggcgg cctcgttatg cagaactaca ggctcattga cgctacactc      240

tacgtgacac tcgaaccttg cgttatgtgc gccggagcta tgattcattc taggattggc      300

agggtcgtgt ttggagctag ggacgctaaa acaggagccg ccggatctct tatggacgtg      360

ttgcatcatc caggcatgaa ccatagggtg gagattacag agggcatctt tgcagacgag      420

tccgctgctc ttctttccga tttcttcagg atgagaaggc aggagattaa ggcccagaag      480

aaggctcagt cttctacaga tagcggagga tcttccggag gatctagcgg ctccgagaca      540

ccaggaacat ccgaaagcgc tacaccagaa tctagcggag gctcttccgg aggatcttct      600

gaagtggagt tctcccacga gtattggatg aggcacgctc ttacacttgc taaaagggct      660

agggacgaaa cggaagttcc agttggagct gttctcgtgc tcaataacag ggtgattggc      720

gagggttgga atagagccat tggactccat gatccaacag ctcacgcaga gattatggct      780

cttagacaag gcggcctcgt tatgcagaat tacagactca tcgacgccac actctacgtt      840

accttcgaac cttgcgttat gtgcgccgga gctatgatcc attctaggat tggcagggtc      900

gtgttcggcg ttagaaacgc taagacagga gctgcaggct ctcttatgga cgttcttcat      960

tacccaggca tgaatcatag agtggagatc acagaaggca ttcttgcaga cgagtgcgca     1020

gctctccttt gctatttctt caggatgccg aggcaagttt tcaacgctca gaacaaggcc     1080

cagtcttcta cagattccgg cggatcttct ggaggatcta gcggctccga gacaccagga     1140

acatccgaat ccgctacacc agagtcttct ggaggatcta gcggaggatc tcttaagcca     1200

aaaaagaaga gaaaggtttc aggcggctcc gacaagaagt actcgatcgg cctcgccatt     1260

gggactaact ctgttggctg ggccgtgatc accgacgagt acaaggtgcc ctcaaagaag     1320

ttcaaggtcc tgggcaacac cgatcggcat tccatcaaga agaatctcat tggcgctctc     1380

ctgttcgaca gcggcgagac ggctgaggct acgcggctca agcgcaccgc ccgcaggcgg     1440

tacacgcgca ggaagaatcg catctgctac ctgcaggaga ttttctccaa cgagatggcg     1500

aaggttgacg attctttctt ccacaggctg gaggagtcat tcctcgtgga ggaggataag     1560

aagcacgagc ggcatccaat cttcggcaac attgtcgacg aggttgccta ccacgagaag     1620

taccctacga tctaccatct gcggaagaag ctcgtggact ccacagataa ggcggacctc     1680

cgcctgatct acctcgctct ggcccacatg attaagttca ggggccattt cctgatcgag     1740

ggggatctca acccggacaa tagcgatgtt gacaagctgt tcatccagct cgtgcagacg     1800

tacaaccagc tcttcgagga gaaccccatt aatgcgtcag gcgtcgacgc gaaggctatc     1860

ctgtccgcta ggctctcgaa gtctcggcgc ctcgagaacc tgatcgccca gctgccgggc     1920

gagaagaaga acggcctgtt cgggaatctc attgcgctca gcctggggct cacgcccaac     1980

ttcaagtcga atttcgatct cgctgaggac gccaagctgc agctctccaa ggacacatac     2040

gacgatgacc tggataacct cctggcccag atcggcgatc agtacgcgga cctgttcctc     2100

gctgccaaga atctgtcgga cgccatcctc ctgtctgata ttctcagggt gaacaccgag     2160

attacgaagg ctccgctctc agcctccatg atcaagcgct acgacgagca ccatcaggat     2220

ctgaccctcc tgaaggcgct ggtcaggcag cagctccccg agaagtacaa ggagatcttc     2280

ttcgatcagt cgaagaacgg ctacgctggg tacattgacg gcggggcctc tcaggaggag     2340

ttctacaagt tcatcaagcc gattctggag aagatggacg gcacggagga gctgctggtg     2400

aagctcaatc gcgaggacct cctgaggaag cagcggacat tcgataacgg cagcatccca     2460

caccagattc atctcgggga gctgcacgct atcctgagga ggcaggagga cttctaccct     2520

ttcctcaagg ataaccgcga gaagatcgag aagattctga ctttcaggat cccgtactac     2580

gtcggcccac tcgctagggg caactcccgc ttcgcttgga tgacccgcaa gtcagaggag     2640

acgatcacgc cgtggaactt cgaggaggtg gtcgacaagg gcgctagcgc tcagtcgttc     2700

atcgagagga tgacgaattt cgacaagaac ctgccaaatg agaaggtgct ccctaagcac     2760

tcgctcctgt acgagtactt cacagtctac aacgagctga ctaaggtgaa gtatgtgacc     2820

gagggcatga ggaagccggc tttcctgtct ggggagcaga agaaggccat cgtggacctc     2880

ctgttcaaga ccaaccggaa ggtcacggtt aagcagctca aggaggacta cttcaagaag     2940

attgagtgct tcgattcggt cgagatctct ggcgttgagg accgcttcaa cgcctccctg     3000

gggacctacc acgatctcct gaagatcatt aaggataagg acttcctgga caacgaggag     3060

aatgaggata tcctcgagga cattgtgctg acactcactc tgttcgagga ccgggagatg     3120

atcgaggagc gcctgaagac ttacgcccat ctcttcgatg acaaggtcat gaagcagctc     3180

aagaggagga ggtacaccgg ctgggggagg ctgagcagga agctcatcaa cggcattcgg     3240

gacaagcagt ccgggaagac gatcctcgac ttcctgaaga gcgatggctt cgcgaaccgc     3300

aatttcatgc agctgattca cgatgacagc ctcacattca aggaggatat ccagaaggct     3360

caggtgagcg gccaggggga ctcgctgcac gagcatatcg cgaacctcgc tggctcgcca     3420

gctatcaaga aggggattct gcagaccgtg aaggttgtgg acgagctggt gaaggtcatg     3480

ggcaggcaca agcctgagaa catcgtcatt gagatggccc gggagaatca gaccacgcag     3540

aagggccaga agaactcacg cgagaggatg aagaggatcg aggagggcat taaggagctg     3600

gggtcccaga tcctcaagga gcacccggtg gagaacacgc agctgcagaa tgagaagctc     3660

tacctgtact acctccagaa tggccgcgat atgtatgtgg accaggagct ggatattaac     3720

aggctcagcg attacgacgt cgatcatatc gttccacagt cattcctgaa ggatgactcc     3780

attgacaaca aggtcctcac caggtcggac aagaaccggg gcaagtctga taatgttcct     3840

tcagaggagg tcgttaagaa gatgaagaac tactggcgcc agctcctgaa tgccaagctg     3900

atcacgcagc ggaagttcga taacctcaca aaggctgaga ggggcgggct ctctgagctg     3960

gacaaggcgg gcttcatcaa gaggcagctg gtcgagacac ggcagatcac taagcacgtt     4020

gcgcagattc tcgactcacg gatgaacact aagtacgatg agaatgacaa gctgatccgc     4080

gaggtgaagg tcatcaccct gaagtcaaag ctcgtctccg acttcaggaa ggatttccag     4140

ttctacaagg ttcgggagat caacaattac caccatgccc atgacgcgta cctgaacgcg     4200

gtggtcggca cagctctgat caagaagtac ccaaagctcg agagcgagtt cgtgtacggg     4260

gactacaagg tttacgatgt gaggaagatg atcgccaagt cggagcagga gattggcaag     4320

gctaccgcca agtacttctt ctactctaac attatgaatt tcttcaagac agagatcact     4380

ctggccaatg gcgagatccg gaagcgcccc ctcatcgaga cgaacggcga gacgggggag     4440

atcgtgtggg acaagggcag ggatttcgcg accgtcagga aggttctctc catgccacaa     4500

gtgaatatcg tcaagaagac agaggtccag actggcgggt tctctaagga gtcaattctg     4560

cctaagcgga acagcgacaa gctcatcgcc cgcaagaagg actgggatcc gaagaagtac     4620

ggcgggttcg acagccccac tgtggcctac tcggtcctgg ttgtggcgaa ggttgagaag     4680

ggcaagtcca agaagctcaa gagcgtgaag gagctgctgg ggatcacgat tatggagcgc     4740

tccagcttcg agaagaaccc gatcgatttc ctggaggcga agggctacaa ggaggtgaag     4800

aaggacctga tcattaagct ccccaagtac tcactcttcg agctggagaa cggcaggaag     4860

cggatgctgg cttccgctgg cgagctgcag aaggggaacg agctggctct gccgtccaag     4920

tatgtgaact tcctctacct ggcctcccac tacgagaagc tcaagggcag ccccgaggac     4980

aacgagcaga agcagctgtt cgtcgagcag cacaagcatt acctcgacga gatcattgag     5040

cagatttccg agttctccaa gcgcgtgatc ctggccgacg cgaatctgga taaggtcctc     5100

tccgcgtaca acaagcaccg cgacaagcca atcagggagc aggctgagaa tatcattcat     5160

ctcttcaccc tgacgaacct cggcgcccct gctgctttca agtacttcga cacaactatc     5220

gatcgcaaga ggtacacaag cactaaggag gtcctggacg cgaccctcat ccaccagtcg     5280

attaccggcc tctacgagac gcgcatcgac ctgtctcagc tcgggggcga caagcggcca     5340

gcggcgacga agaaggcggg gcaggcgaag aagaagaagt ag                        5382


<210>  29
<211>  5382
<212>  DNA
<213>  artificial sequence

<220>
<223>  PABE-4

<400>  29
atgccaaaaa agaagagaaa ggtttcaggc ggctccgaca agaagtactc gatcggcctc       60

gccattggga ctaactctgt tggctgggcc gtgatcaccg acgagtacaa ggtgccctca      120

aagaagttca aggtcctggg caacaccgat cggcattcca tcaagaagaa tctcattggc      180

gctctcctgt tcgacagcgg cgagacggct gaggctacgc ggctcaagcg caccgcccgc      240

aggcggtaca cgcgcaggaa gaatcgcatc tgctacctgc aggagatttt ctccaacgag      300

atggcgaagg ttgacgattc tttcttccac aggctggagg agtcattcct cgtggaggag      360

gataagaagc acgagcggca tccaatcttc ggcaacattg tcgacgaggt tgcctaccac      420

gagaagtacc ctacgatcta ccatctgcgg aagaagctcg tggactccac agataaggcg      480

gacctccgcc tgatctacct cgctctggcc cacatgatta agttcagggg ccatttcctg      540

atcgaggggg atctcaaccc ggacaatagc gatgttgaca agctgttcat ccagctcgtg      600

cagacgtaca accagctctt cgaggagaac cccattaatg cgtcaggcgt cgacgcgaag      660

gctatcctgt ccgctaggct ctcgaagtct cggcgcctcg agaacctgat cgcccagctg      720

ccgggcgaga agaagaacgg cctgttcggg aatctcattg cgctcagcct ggggctcacg      780

cccaacttca agtcgaattt cgatctcgct gaggacgcca agctgcagct ctccaaggac      840

acatacgacg atgacctgga taacctcctg gcccagatcg gcgatcagta cgcggacctg      900

ttcctcgctg ccaagaatct gtcggacgcc atcctcctgt ctgatattct cagggtgaac      960

accgagatta cgaaggctcc gctctcagcc tccatgatca agcgctacga cgagcaccat     1020

caggatctga ccctcctgaa ggcgctggtc aggcagcagc tccccgagaa gtacaaggag     1080

atcttcttcg atcagtcgaa gaacggctac gctgggtaca ttgacggcgg ggcctctcag     1140

gaggagttct acaagttcat caagccgatt ctggagaaga tggacggcac ggaggagctg     1200

ctggtgaagc tcaatcgcga ggacctcctg aggaagcagc ggacattcga taacggcagc     1260

atcccacacc agattcatct cggggagctg cacgctatcc tgaggaggca ggaggacttc     1320

taccctttcc tcaaggataa ccgcgagaag atcgagaaga ttctgacttt caggatcccg     1380

tactacgtcg gcccactcgc taggggcaac tcccgcttcg cttggatgac ccgcaagtca     1440

gaggagacga tcacgccgtg gaacttcgag gaggtggtcg acaagggcgc tagcgctcag     1500

tcgttcatcg agaggatgac gaatttcgac aagaacctgc caaatgagaa ggtgctccct     1560

aagcactcgc tcctgtacga gtacttcaca gtctacaacg agctgactaa ggtgaagtat     1620

gtgaccgagg gcatgaggaa gccggctttc ctgtctgggg agcagaagaa ggccatcgtg     1680

gacctcctgt tcaagaccaa ccggaaggtc acggttaagc agctcaagga ggactacttc     1740

aagaagattg agtgcttcga ttcggtcgag atctctggcg ttgaggaccg cttcaacgcc     1800

tccctgggga cctaccacga tctcctgaag atcattaagg ataaggactt cctggacaac     1860

gaggagaatg aggatatcct cgaggacatt gtgctgacac tcactctgtt cgaggaccgg     1920

gagatgatcg aggagcgcct gaagacttac gcccatctct tcgatgacaa ggtcatgaag     1980

cagctcaaga ggaggaggta caccggctgg gggaggctga gcaggaagct catcaacggc     2040

attcgggaca agcagtccgg gaagacgatc ctcgacttcc tgaagagcga tggcttcgcg     2100

aaccgcaatt tcatgcagct gattcacgat gacagcctca cattcaagga ggatatccag     2160

aaggctcagg tgagcggcca gggggactcg ctgcacgagc atatcgcgaa cctcgctggc     2220

tcgccagcta tcaagaaggg gattctgcag accgtgaagg ttgtggacga gctggtgaag     2280

gtcatgggca ggcacaagcc tgagaacatc gtcattgaga tggcccggga gaatcagacc     2340

acgcagaagg gccagaagaa ctcacgcgag aggatgaaga ggatcgagga gggcattaag     2400

gagctggggt cccagatcct caaggagcac ccggtggaga acacgcagct gcagaatgag     2460

aagctctacc tgtactacct ccagaatggc cgcgatatgt atgtggacca ggagctggat     2520

attaacaggc tcagcgatta cgacgtcgat catatcgttc cacagtcatt cctgaaggat     2580

gactccattg acaacaaggt cctcaccagg tcggacaaga accggggcaa gtctgataat     2640

gttccttcag aggaggtcgt taagaagatg aagaactact ggcgccagct cctgaatgcc     2700

aagctgatca cgcagcggaa gttcgataac ctcacaaagg ctgagagggg cgggctctct     2760

gagctggaca aggcgggctt catcaagagg cagctggtcg agacacggca gatcactaag     2820

cacgttgcgc agattctcga ctcacggatg aacactaagt acgatgagaa tgacaagctg     2880

atccgcgagg tgaaggtcat caccctgaag tcaaagctcg tctccgactt caggaaggat     2940

ttccagttct acaaggttcg ggagatcaac aattaccacc atgcccatga cgcgtacctg     3000

aacgcggtgg tcggcacagc tctgatcaag aagtacccaa agctcgagag cgagttcgtg     3060

tacggggact acaaggttta cgatgtgagg aagatgatcg ccaagtcgga gcaggagatt     3120

ggcaaggcta ccgccaagta cttcttctac tctaacatta tgaatttctt caagacagag     3180

atcactctgg ccaatggcga gatccggaag cgccccctca tcgagacgaa cggcgagacg     3240

ggggagatcg tgtgggacaa gggcagggat ttcgcgaccg tcaggaaggt tctctccatg     3300

ccacaagtga atatcgtcaa gaagacagag gtccagactg gcgggttctc taaggagtca     3360

attctgccta agcggaacag cgacaagctc atcgcccgca agaaggactg ggatccgaag     3420

aagtacggcg ggttcgacag ccccactgtg gcctactcgg tcctggttgt ggcgaaggtt     3480

gagaagggca agtccaagaa gctcaagagc gtgaaggagc tgctggggat cacgattatg     3540

gagcgctcca gcttcgagaa gaacccgatc gatttcctgg aggcgaaggg ctacaaggag     3600

gtgaagaagg acctgatcat taagctcccc aagtactcac tcttcgagct ggagaacggc     3660

aggaagcgga tgctggcttc cgctggcgag ctgcagaagg ggaacgagct ggctctgccg     3720

tccaagtatg tgaacttcct ctacctggcc tcccactacg agaagctcaa gggcagcccc     3780

gaggacaacg agcagaagca gctgttcgtc gagcagcaca agcattacct cgacgagatc     3840

attgagcaga tttccgagtt ctccaagcgc gtgatcctgg ccgacgcgaa tctggataag     3900

gtcctctccg cgtacaacaa gcaccgcgac aagccaatca gggagcaggc tgagaatatc     3960

attcatctct tcaccctgac gaacctcggc gcccctgctg ctttcaagta cttcgacaca     4020

actatcgatc gcaagaggta cacaagcact aaggaggtcc tggacgcgac cctcatccac     4080

cagtcgatta ccggcctcta cgagacgcgc atcgacctgt ctcagctcgg gggcgacgaa     4140

ttctccggcg gatcttctgg aggatctagc ggctccgaga caccaggaac atccgaatcc     4200

gctacaccag agtcttctgg aggatctagc ggaggatctt ccgaggtgga gttctctcac     4260

gagtattgga tgaggcacgc tcttacactt gctaagagag cttgggacga aagagaagtg     4320

ccagttggcg ccgttcttgt gcataataat agggtgatcg gcgagggttg gaatagacca     4380

attggaaggc atgatccaac agctcacgca gagattatgg ctctcagaca aggcggcctc     4440

gttatgcaga actacaggct cattgacgct acactctacg tgacactcga accttgcgtt     4500

atgtgcgccg gagctatgat tcattctagg attggcaggg tcgtgtttgg agctagggac     4560

gctaaaacag gagccgccgg atctcttatg gacgtgttgc atcatccagg catgaaccat     4620

agggtggaga ttacagaggg cattcttgca gacgagtgcg ctgctcttct ttccgatttc     4680

ttcaggatga gaaggcagga gattaaggcc cagaagaagg ctcagtcttc tacagatagc     4740

ggaggatctt ccggaggatc tagcggctcc gagacaccag gaacatccga aagcgctaca     4800

ccagaatcta gcggaggctc ttccggagga tcttctgaag tggagttctc ccacgagtat     4860

tggatgaggc acgctcttac acttgctaaa agggctaggg acgaaaggga agttccagtt     4920

ggagctgttc tcgtgctcaa taacagggtg attggcgagg gttggaatag agccattgga     4980

ctccatgatc caacagctca cgcagagatt atggctctta gacaaggcgg cctcgttatg     5040

cagaattaca gactcatcga cgccacactc tacgttacct tcgaaccttg cgttatgtgc     5100

gccggagcta tgatccattc taggattggc agggtcgtgt tcggcgttag aaacgctaag     5160

acaggagctg caggctctct tatggacgtt cttcattacc caggcatgaa tcatagagtg     5220

gagatcacag aaggcattct tgcagacgag tgcgcagctc tcctttgcta tttcttcagg     5280

atgccgaggc aagttttcaa cgctcagaag aaggcccagt cttctacaga taagagacca     5340

gcagctacaa agaaggccgg acaagctaag aagaagaagt ag                        5382


<210>  30
<211>  5403
<212>  DNA
<213>  artificial sequence

<220>
<223>  PABE-5

<400>  30
atgccaaaaa agaagagaaa ggtttcaggc ggctccgaca agaagtactc gatcggcctc       60

gccattggga ctaactctgt tggctgggcc gtgatcaccg acgagtacaa ggtgccctca      120

aagaagttca aggtcctggg caacaccgat cggcattcca tcaagaagaa tctcattggc      180

gctctcctgt tcgacagcgg cgagacggct gaggctacgc ggctcaagcg caccgcccgc      240

aggcggtaca cgcgcaggaa gaatcgcatc tgctacctgc aggagatttt ctccaacgag      300

atggcgaagg ttgacgattc tttcttccac aggctggagg agtcattcct cgtggaggag      360

gataagaagc acgagcggca tccaatcttc ggcaacattg tcgacgaggt tgcctaccac      420

gagaagtacc ctacgatcta ccatctgcgg aagaagctcg tggactccac agataaggcg      480

gacctccgcc tgatctacct cgctctggcc cacatgatta agttcagggg ccatttcctg      540

atcgaggggg atctcaaccc ggacaatagc gatgttgaca agctgttcat ccagctcgtg      600

cagacgtaca accagctctt cgaggagaac cccattaatg cgtcaggcgt cgacgcgaag      660

gctatcctgt ccgctaggct ctcgaagtct cggcgcctcg agaacctgat cgcccagctg      720

ccgggcgaga agaagaacgg cctgttcggg aatctcattg cgctcagcct ggggctcacg      780

cccaacttca agtcgaattt cgatctcgct gaggacgcca agctgcagct ctccaaggac      840

acatacgacg atgacctgga taacctcctg gcccagatcg gcgatcagta cgcggacctg      900

ttcctcgctg ccaagaatct gtcggacgcc atcctcctgt ctgatattct cagggtgaac      960

accgagatta cgaaggctcc gctctcagcc tccatgatca agcgctacga cgagcaccat     1020

caggatctga ccctcctgaa ggcgctggtc aggcagcagc tccccgagaa gtacaaggag     1080

atcttcttcg atcagtcgaa gaacggctac gctgggtaca ttgacggcgg ggcctctcag     1140

gaggagttct acaagttcat caagccgatt ctggagaaga tggacggcac ggaggagctg     1200

ctggtgaagc tcaatcgcga ggacctcctg aggaagcagc ggacattcga taacggcagc     1260

atcccacacc agattcatct cggggagctg cacgctatcc tgaggaggca ggaggacttc     1320

taccctttcc tcaaggataa ccgcgagaag atcgagaaga ttctgacttt caggatcccg     1380

tactacgtcg gcccactcgc taggggcaac tcccgcttcg cttggatgac ccgcaagtca     1440

gaggagacga tcacgccgtg gaacttcgag gaggtggtcg acaagggcgc tagcgctcag     1500

tcgttcatcg agaggatgac gaatttcgac aagaacctgc caaatgagaa ggtgctccct     1560

aagcactcgc tcctgtacga gtacttcaca gtctacaacg agctgactaa ggtgaagtat     1620

gtgaccgagg gcatgaggaa gccggctttc ctgtctgggg agcagaagaa ggccatcgtg     1680

gacctcctgt tcaagaccaa ccggaaggtc acggttaagc agctcaagga ggactacttc     1740

aagaagattg agtgcttcga ttcggtcgag atctctggcg ttgaggaccg cttcaacgcc     1800

tccctgggga cctaccacga tctcctgaag atcattaagg ataaggactt cctggacaac     1860

gaggagaatg aggatatcct cgaggacatt gtgctgacac tcactctgtt cgaggaccgg     1920

gagatgatcg aggagcgcct gaagacttac gcccatctct tcgatgacaa ggtcatgaag     1980

cagctcaaga ggaggaggta caccggctgg gggaggctga gcaggaagct catcaacggc     2040

attcgggaca agcagtccgg gaagacgatc ctcgacttcc tgaagagcga tggcttcgcg     2100

aaccgcaatt tcatgcagct gattcacgat gacagcctca cattcaagga ggatatccag     2160

aaggctcagg tgagcggcca gggggactcg ctgcacgagc atatcgcgaa cctcgctggc     2220

tcgccagcta tcaagaaggg gattctgcag accgtgaagg ttgtggacga gctggtgaag     2280

gtcatgggca ggcacaagcc tgagaacatc gtcattgaga tggcccggga gaatcagacc     2340

acgcagaagg gccagaagaa ctcacgcgag aggatgaaga ggatcgagga gggcattaag     2400

gagctggggt cccagatcct caaggagcac ccggtggaga acacgcagct gcagaatgag     2460

aagctctacc tgtactacct ccagaatggc cgcgatatgt atgtggacca ggagctggat     2520

attaacaggc tcagcgatta cgacgtcgat catatcgttc cacagtcatt cctgaaggat     2580

gactccattg acaacaaggt cctcaccagg tcggacaaga accggggcaa gtctgataat     2640

gttccttcag aggaggtcgt taagaagatg aagaactact ggcgccagct cctgaatgcc     2700

aagctgatca cgcagcggaa gttcgataac ctcacaaagg ctgagagggg cgggctctct     2760

gagctggaca aggcgggctt catcaagagg cagctggtcg agacacggca gatcactaag     2820

cacgttgcgc agattctcga ctcacggatg aacactaagt acgatgagaa tgacaagctg     2880

atccgcgagg tgaaggtcat caccctgaag tcaaagctcg tctccgactt caggaaggat     2940

ttccagttct acaaggttcg ggagatcaac aattaccacc atgcccatga cgcgtacctg     3000

aacgcggtgg tcggcacagc tctgatcaag aagtacccaa agctcgagag cgagttcgtg     3060

tacggggact acaaggttta cgatgtgagg aagatgatcg ccaagtcgga gcaggagatt     3120

ggcaaggcta ccgccaagta cttcttctac tctaacatta tgaatttctt caagacagag     3180

atcactctgg ccaatggcga gatccggaag cgccccctca tcgagacgaa cggcgagacg     3240

ggggagatcg tgtgggacaa gggcagggat ttcgcgaccg tcaggaaggt tctctccatg     3300

ccacaagtga atatcgtcaa gaagacagag gtccagactg gcgggttctc taaggagtca     3360

attctgccta agcggaacag cgacaagctc atcgcccgca agaaggactg ggatccgaag     3420

aagtacggcg ggttcgacag ccccactgtg gcctactcgg tcctggttgt ggcgaaggtt     3480

gagaagggca agtccaagaa gctcaagagc gtgaaggagc tgctggggat cacgattatg     3540

gagcgctcca gcttcgagaa gaacccgatc gatttcctgg aggcgaaggg ctacaaggag     3600

gtgaagaagg acctgatcat taagctcccc aagtactcac tcttcgagct ggagaacggc     3660

aggaagcgga tgctggcttc cgctggcgag ctgcagaagg ggaacgagct ggctctgccg     3720

tccaagtatg tgaacttcct ctacctggcc tcccactacg agaagctcaa gggcagcccc     3780

gaggacaacg agcagaagca gctgttcgtc gagcagcaca agcattacct cgacgagatc     3840

attgagcaga tttccgagtt ctccaagcgc gtgatcctgg ccgacgcgaa tctggataag     3900

gtcctctccg cgtacaacaa gcaccgcgac aagccaatca gggagcaggc tgagaatatc     3960

attcatctct tcaccctgac gaacctcggc gcccctgctg ctttcaagta cttcgacaca     4020

actatcgatc gcaagaggta cacaagcact aaggaggtcc tggacgcgac cctcatccac     4080

cagtcgatta ccggcctcta cgagacgcgc atcgacctgt ctcagctcgg gggcgacgaa     4140

ttcccaaaga agaagcgcaa ggtctccggc ggatcttctg gaggatctag cggctccgag     4200

acaccaggaa catccgaatc cgctacacca gagtcttctg gaggatctag cggaggatct     4260

tccgaggtgg agttctctca cgagtattgg atgaggcacg ctcttacact tgctaagaga     4320

gcttgggacg aaagagaagt gccagttggc gccgttcttg tgcataataa tagggtgatc     4380

ggcgagggtt ggaatagacc aattggaagg catgatccaa cagctcacgc agagattatg     4440

gctctcagac aaggcggcct cgttatgcag aactacaggc tcattgacgc tacactctac     4500

gtgacactcg aaccttgcgt tatgtgcgcc ggagctatga ttcattctag gattggcagg     4560

gtcgtgtttg gagctaggga cgctaaaaca ggagccgccg gatctcttat ggacgtgttg     4620

catcatccag gcatgaacca tagggtggag attacagagg gcattcttgc agacgagtgc     4680

gctgctcttc tttccgattt cttcaggatg agaaggcagg agattaaggc ccagaagaag     4740

gctcagtctt ctacagatag cggaggatct tccggaggat ctagcggctc cgagacacca     4800

ggaacatccg aaagcgctac accagaatct agcggaggct cttccggagg atcttctgaa     4860

gtggagttct cccacgagta ttggatgagg cacgctctta cacttgctaa aagggctagg     4920

gacgaaaggg aagttccagt tggagctgtt ctcgtgctca ataacagggt gattggcgag     4980

ggttggaata gagccattgg actccatgat ccaacagctc acgcagagat tatggctctt     5040

agacaaggcg gcctcgttat gcagaattac agactcatcg acgccacact ctacgttacc     5100

ttcgaacctt gcgttatgtg cgccggagct atgatccatt ctaggattgg cagggtcgtg     5160

ttcggcgtta gaaacgctaa gacaggagct gcaggctctc ttatggacgt tcttcattac     5220

ccaggcatga atcatagagt ggagatcaca gaaggcattc ttgcagacga gtgcgcagct     5280

ctcctttgct atttcttcag gatgccgagg caagttttca acgctcagaa gaaggcccag     5340

tcttctacag ataagagacc agcagctaca aagaaggccg gacaagctaa gaagaagaag     5400

tag                                                                   5403


<210>  31
<211>  5367
<212>  DNA
<213>  artificial sequence

<220>
<223>  PABE-6

<400>  31
atgtccgagg tggagttctc tcacgagtat tggatgaggc acgctcttac acttgctaag       60

agagcttggg acgaaagaga agtgccagtt ggcgccgttc ttgtgcataa taatagggtg      120

atcggcgagg gttggaatag accaattgga aggcatgatc caacagctca cgcagagatt      180

atggctctca gacaaggcgg cctcgttatg cagaactaca ggctcattga cgctacactc      240

tacgtgacac tcgaaccttg cgttatgtgc gccggagcta tgattcattc taggattggc      300

agggtcgtgt ttggagctag ggacgctaaa acaggagccg ccggatctct tatggacgtg      360

ttgcatcatc caggcatgaa ccatagggtg gagattacag agggcattct tgcagacgag      420

tgcgctgctc ttctttccga tttcttcagg atgagaaggc aggagattaa ggcccagaag      480

aaggctcagt cttctacaga tagcggagga tcttccggag gatctagcgg ctccgagaca      540

ccaggaacat ccgaaagcgc tacaccagaa tctagcggag gctcttccgg aggatcttct      600

gaagtggagt tctcccacga gtattggatg aggcacgctc ttacacttgc taaaagggct      660

agggacgaaa gggaagttcc agttggagct gttctcgtgc tcaataacag ggtgattggc      720

gagggttgga atagagccat tggactccat gatccaacag ctcacgcaga gattatggct      780

cttagacaag gcggcctcgt tatgcagaat tacagactca tcgacgccac actctacgtt      840

accttcgaac cttgcgttat gtgcgccgga gctatgatcc attctaggat tggcagggtc      900

gtgttcggcg ttagaaacgc taagacagga gctgcaggct ctcttatgga cgttcttcat      960

tacccaggca tgaatcatag agtggagatc acagaaggca ttcttgcaga cgagtgcgca     1020

gctctccttt gctatttctt caggatgccg aggcaagttt tcaacgctca gaagaaggcc     1080

cagtcttcta cagattccgg cggatcttct ggaggatcta gcggctccca gacaccagga     1140

acatccgaat ccgctacacc agagtcttct ggaggatcta gcggaggatc tcttaaggac     1200

aagaagtact cgatcggcct cgccattggg actaactctg ttggctgggc cgtgatcacc     1260

gacgagtaca aggtgccctc aaagaagttc aaggtcctgg gcaacaccga tcggcattcc     1320

atcaagaaga atctcattgg cgctctcctg ttcgacagcg gcgagacggc tgaggctacg     1380

cggctcaagc gcaccgcccg caggcggtac acgcgcagga agaatcgcat ctgctacctg     1440

caggagattt tctccaacga gatggcgaag gttgacgatt ctttcttcca caggctggag     1500

gagtcattcc tcgtggagga ggataagaag cacgagcggc atccaatctt cggcaacatt     1560

gtcgacgagg ttgcctacca cgagaagtac cctacgatct accatctgcg gaagaagctc     1620

gtggactcca cagataaggc ggacctccgc ctgatctacc tcgctctggc ccacatgatt     1680

aagttcaggg gccatttcct gatcgagggg gatctcaacc cggacaatag cgatgttgac     1740

aagctgttca tccagctcgt gcagacgtac aaccagctct tcgaggagaa ccccattaat     1800

gcgtcaggcg tcgacgcgaa ggctatcctg tccgctaggc tctcgaagtc tcggcgcctc     1860

gagaacctga tcgcccagct gccgggcgag aagaagaacg gcctgttcgg gaatctcatt     1920

gcgctcagcc tggggctcac gcccaacttc aagtcgaatt tcgatctcgc tgaggacgcc     1980

aagctgcagc tctccaagga cacatacgac gatgacctgg ataacctcct ggcccagatc     2040

ggcgatcagt acgcggacct gttcctcgct gccaagaatc tgtcggacgc catcctcctg     2100

tctgatattc tcagggtgaa caccgagatt acgaaggctc cgctctcagc ctccatgatc     2160

aagcgctacg acgagcacca tcaggatctg accctcctga aggcgctggt caggcagcag     2220

ctccccgaga agtacaagga gatcttcttc gatcagtcga agaacggcta cgctgggtac     2280

attgacggcg gggcctctca ggaggagttc tacaagttca tcaagccgat tctggagaag     2340

atggacggca cggaggagct gctggtgaag ctcaatcgcg aggacctcct gaggaagcag     2400

cggacattcg ataacggcag catcccacac cagattcatc tcggggagct gcacgctatc     2460

ctgaggaggc aggaggactt ctaccctttc ctcaaggata accgcgagaa gatcgagaag     2520

attctgactt tcaggatccc gtactacgtc ggcccactcg ctaggggcaa ctcccgcttc     2580

gcttggatga cccgcaagtc agaggagacg atcacgccgt ggaacttcga ggaggtggtc     2640

gacaagggcg ctagcgctca gtcgttcatc gagaggatga cgaatttcga caagaacctg     2700

ccaaatgaga aggtgctccc taagcactcg ctcctgtacg agtacttcac agtctacaac     2760

gagctgacta aggtgaagta tgtgaccgag ggcatgagga agccggcttt cctgtctggg     2820

gagcagaaga aggccatcgt ggacctcctg ttcaagacca accggaaggt cacggttaag     2880

cagctcaagg aggactactt caagaagatt gagtgcttcg attcggtcga gatctctggc     2940

gttgaggacc gcttcaacgc ctccctgggg acctaccacg atctcctgaa gatcattaag     3000

gataaggact tcctggacaa cgaggagaat gaggatatcc tcgaggacat tgtgctgaca     3060

ctcactctgt tcgaggaccg ggagatgatc gaggagcgcc tgaagactta cgcccatctc     3120

ttcgatgaca aggtcatgaa gcagctcaag aggaggaggt acaccggctg ggggaggctg     3180

agcaggaagc tcatcaacgg cattcgggac aagcagtccg ggaagacgat cctcgacttc     3240

ctgaagagcg atggcttcgc gaaccgcaat ttcatgcagc tgattcacga tgacagcctc     3300

acattcaagg aggatatcca gaaggctcag gtgagcggcc agggggactc gctgcacgag     3360

catatcgcga acctcgctgg ctcgccagct atcaagaagg ggattctgca gaccgtgaag     3420

gttgtggacg agctggtgaa ggtcatgggc aggcacaagc ctgagaacat cgtcattgag     3480

atggcccggg agaatcagac cacgcagaag ggccagaaga actcacgcga gaggatgaag     3540

aggatcgagg agggcattaa ggagctgggg tcccagatcc tcaaggagca cccggtggag     3600

aacacgcagc tgcagaatga gaagctctac ctgtactacc tccagaatgg ccgcgatatg     3660

tatgtggacc aggagctgga tattaacagg ctcagcgatt acgacgtcga tcatatcgtt     3720

ccacagtcat tcctgaagga tgactccatt gacaacaagg tcctcaccag gtcggacaag     3780

aaccggggca agtctgataa tgttccttca gaggaggtcg ttaagaagat gaagaactac     3840

tggcgccagc tcctgaatgc caagctgatc acgcagcgga agttcgataa cctcacaaag     3900

gctgagaggg gcgggctctc tgagctggac aaggcgggct tcatcaagag gcagctggtc     3960

gagacacggc agatcactaa gcacgttgcg cagattctcg actcacggat gaacactaag     4020

tacgatgaga atgacaagct gatccgcgag gtgaaggtca tcaccctgaa gtcaaagctc     4080

gtctccgact tcaggaagga tttccagttc tacaaggttc gggagatcaa caattaccac     4140

catgcccatg acgcgtacct gaacgcggtg gtcggcacag ctctgatcaa gaagtaccca     4200

aagctcgaga gcgagttcgt gtacggggac tacaaggttt acgatgtgag gaagatgatc     4260

gccaagtcgg agcaggagat tggcaaggct accgccaagt acttcttcta ctctaacatt     4320

atgaatttct tcaagacaga gatcactctg gccaatggcg agatccggaa gcgccccctc     4380

atcgagacga acggcgagac gggggagatc gtgtgggaca agggcaggga tttcgcgacc     4440

gtcaggaagg ttctctccat gccacaagtg aatatcgtca agaagacaga ggtccagact     4500

ggcgggttct ctaaggagtc aattctgcct aagcggaaca gcgacaagct catcgcccgc     4560

aagaaggact gggatccgaa gaagtacggc gggttcgaca gccccactgt ggcctactcg     4620

gtcctggttg tggcgaaggt tgagaagggc aagtccaaga agctcaagag cgtgaaggag     4680

ctgctgggga tcacgattat ggagcgctcc agcttcgaga agaacccgat cgatttcctg     4740

gaggcgaagg gctacaagga ggtgaagaag gacctgatca ttaagctccc caagtactca     4800

ctcttcgagc tggagaacgg caggaagcgg atgctggctt ccgctggcga gctgcagaag     4860

gggaacgagc tggctctgcc gtccaagtat gtgaacttcc tctacctggc ctcccactac     4920

gagaagctca agggcagccc cgaggacaac gagcagaagc agctgttcgt cgagcagcac     4980

aagcattacc tcgacgagat cattgagcag atttccgagt tctccaagcg cgtgatcctg     5040

gccgacgcga atctggataa ggtcctctcc gcgtacaaca agcaccgcga caagccaatc     5100

agggagcagg ctgagaatat cattcatctc ttcaccctga cgaacctcgg cgcccctgct     5160

gctttcaagt acttcgacac aactatcgat cgcaagaggt acacaagcac taaggaggtc     5220

ctggacgcga ccctcatcca ccagtcgatt accggcctct acgagacgcg catcgacctg     5280

tctcagctcg ggggcgactc cggcggcagc ccaaagaaga agcggaaggt gtctggaggt     5340

tctcctaaga aaaagagaaa agtgtag                                         5367


<210>  32
<211>  5400
<212>  DNA
<213>  artificial sequence

<220>
<223>  PABE-7

<400>  32
atgtccgagg tggagttctc tcacgagtat tggatgaggc acgctcttac acttgctaag       60

agagcttggg acgaaagaga agtgccagtt ggcgccgttc ttgtgcataa taatagggtg      120

atcggcgagg gttggaatag accaattgga aggcatgatc caacagctca cgcagagatt      180

atggctctca gacaaggcgg cctcgttatg cagaactaca ggctcattga cgctacactc      240

tacgtgacac tcgaaccttg cgttatgtgc gccggagcta tgattcattc taggattggc      300

agggtcgtgt ttggagctag ggacgctaaa acaggagccg ccggatctct tatggacgtg      360

ttgcatcatc caggcatgaa ccatagggtg gagattacag agggcattct tgcagacgag      420

tgcgctgctc ttctttccga tttcttcagg atgagaaggc aggagattaa ggcccagaag      480

aaggctcagt cttctacaga tagcggagga tcttccggag gatctagcgg ctccgagaca      540

ccaggaacat ccgaaagcgc tacaccagaa tctagcggag gctcttccgg aggatcttct      600

gaagtggagt tctcccacga gtattggatg aggcacgctc ttacacttgc taaaagggct      660

agggacgaaa gggaagttcc agttggagct gttctcgtgc tcaataacag ggtgattggc      720

gagggttgga atagagccat tggactccat gatccaacag ctcacgcaga gattatggct      780

cttagacaag gcggcctcgt tatgcagaat tacagactca tcgacgccac actctacgtt      840

accttcgaac cttgcgttat gtgcgccgga gctatgatcc attctaggat tggcagggtc      900

gtgttcggcg ttagaaacgc taagacagga gctgcaggct ctcttatgga cgttcttcat      960

tacccaggca tgaatcatag agtggagatc acagaaggca ttcttgcaga cgagtgcgca     1020

gctctccttt gctatttctt caggatgccg aggcaagttt tcaacgctca gaagaaggcc     1080

cagtcttcta cagattccgg cggatcttct ggaggatcta gcggctccga gacaccagga     1140

acatccgaat ccgctacacc agagtcttct ggaggatcta gcggaggatc tcttaaggac     1200

aagaagtact cgatcggcct cgccattggg actaactctg ttggctgggc cgtgatcacc     1260

gacgagtaca aggtgccctc aaagaagttc aaggtcctgg gcaacaccga tcggcattcc     1320

atcaagaaga atctcattgg cgctctcctg ttcgacagcg gcgagacggc tgaggctacg     1380

cggctcaagc gcaccgcccg caggcggtac acgcgcagga agaatcgcat ctgctacctg     1440

caggagattt tctccaacga gatggcgaag gttgacgatt ctttcttcca caggctggag     1500

gagtcattcc tcgtggagga ggataagaag cacgagcggc atccaatctt cggcaacatt     1560

gtcgacgagg ttgcctacca cgagaagtac cctacgatct accatctgcg gaagaagctc     1620

gtggactcca cagataaggc ggacctccgc ctgatctacc tcgctctggc ccacatgatt     1680

aagttcaggg gccatttcct gatcgagggg gatctcaacc cggacaatag cgatgttgac     1740

aagctgttca tccagctcgt gcagacgtac aaccagctct tcgaggagaa ccccattaat     1800

gcgtcaggcg tcgacgcgaa ggctatcctg tccgctaggc tctcgaagtc tcggcgcctc     1860

gagaacctga tcgcccagct gccgggcgag aagaagaacg gcctgttcgg gaatctcatt     1920

gcgctcagcc tggggctcac gcccaacttc aagtcgaatt tcgatctcgc tgaggacgcc     1980

aagctgcagc tctccaagga cacatacgac gatgacctgg ataacctcct ggcccagatc     2040

ggcgatcagt acgcggacct gttcctcgct gccaagaatc tgtcggacgc catcctcctg     2100

tctgatattc tcagggtgaa caccgagatt acgaaggctc cgctctcagc ctccatgatc     2160

aagcgctacg acgagcacca tcaggatctg accctcctga aggcgctggt caggcagcag     2220

ctccccgaga agtacaagga gatcttcttc gatcagtcga agaacggcta cgctgggtac     2280

attgacggcg gggcctctca ggaggagttc tacaagttca tcaagccgat tctggagaag     2340

atggacggca cggaggagct gctggtgaag ctcaatcgcg aggacctcct gaggaagcag     2400

cggacattcg ataacggcag catcccacac cagattcatc tcggggagct gcacgctatc     2460

ctgaggaggc aggaggactt ctaccctttc ctcaaggata accgcgagaa gatcgagaag     2520

attctgactt tcaggatccc gtactacgtc ggcccactcg ctaggggcaa ctcccgcttc     2580

gcttggatga cccgcaagtc agaggagacg atcacgccgt ggaacttcga ggaggtggtc     2640

gacaagggcg ctagcgctca gtcgttcatc gagaggatga cgaatttcga caagaacctg     2700

ccaaatgaga aggtgctccc taagcactcg ctcctgtacg agtacttcac agtctacaac     2760

gagctgacta aggtgaagta tgtgaccgag ggcatgagga agccggcttt cctgtctggg     2820

gagcagaaga aggccatcgt ggacctcctg ttcaagacca accggaaggt cacggttaag     2880

cagctcaagg aggactactt caagaagatt gagtgcttcg attcggtcga gatctctggc     2940

gttgaggacc gcttcaacgc ctccctgggg acctaccacg atctcctgaa gatcattaag     3000

gataaggact tcctggacaa cgaggagaat gaggatatcc tcgaggacat tgtgctgaca     3060

ctcactctgt tcgaggaccg ggagatgatc gaggagcgcc tgaagactta cgcccatctc     3120

ttcgatgaca aggtcatgaa gcagctcaag aggaggaggt acaccggctg ggggaggctg     3180

agcaggaagc tcatcaacgg cattcgggac aagcagtccg ggaagacgat cctcgacttc     3240

ctgaagagcg atggcttcgc gaaccgcaat ttcatgcagc tgattcacga tgacagcctc     3300

acattcaagg aggatatcca gaaggctcag gtgagcggcc agggggactc gctgcacgag     3360

catatcgcga acctcgctgg ctcgccagct atcaagaagg ggattctgca gaccgtgaag     3420

gttgtggacg agctggtgaa ggtcatgggc aggcacaagc ctgagaacat cgtcattgag     3480

atggcccggg agaatcagac cacgcagaag ggccagaaga actcacgcga gaggatgaag     3540

aggatcgagg agggcattaa ggagctgggg tcccagatcc tcaaggagca cccggtggag     3600

aacacgcagc tgcagaatga gaagctctac ctgtactacc tccagaatgg ccgcgatatg     3660

tatgtggacc aggagctgga tattaacagg ctcagcgatt acgacgtcga tcatatcgtt     3720

ccacagtcat tcctgaagga tgactccatt gacaacaagg tcctcaccag gtcggacaag     3780

aaccggggca agtctgataa tgttccttca gaggaggtcg ttaagaagat gaagaactac     3840

tggcgccagc tcctgaatgc caagctgatc acgcagcgga agttcgataa cctcacaaag     3900

gctgagaggg gcgggctctc tgagctggac aaggcgggct tcatcaagag gcagctggtc     3960

gagacacggc agatcactaa gcacgttgcg cagattctcg actcacggat gaacactaag     4020

tacgatgaga atgacaagct gatccgcgag gtgaaggtca tcaccctgaa gtcaaagctc     4080

gtctccgact tcaggaagga tttccagttc tacaaggttc gggagatcaa caattaccac     4140

catgcccatg acgcgtacct gaacgcggtg gtcggcacag ctctgatcaa gaagtaccca     4200

aagctcgaga gcgagttcgt gtacggggac tacaaggttt acgatgtgag gaagatgatc     4260

gccaagtcgg agcaggagat tggcaaggct accgccaagt acttcttcta ctctaacatt     4320

atgaatttct tcaagacaga gatcactctg gccaatggcg agatccggaa gcgccccctc     4380

atcgagacga acggcgagac gggggagatc gtgtgggaca agggcaggga tttcgcgacc     4440

gtcaggaagg ttctctccat gccacaagtg aatatcgtca agaagacaga ggtccagact     4500

ggcgggttct ctaaggagtc aattctgcct aagcggaaca gcgacaagct catcgcccgc     4560

aagaaggact gggatccgaa gaagtacggc gggttcgaca gccccactgt ggcctactcg     4620

gtcctggttg tggcgaaggt tgagaagggc aagtccaaga agctcaagag cgtgaaggag     4680

ctgctgggga tcacgattat ggagcgctcc agcttcgaga agaacccgat cgatttcctg     4740

gaggcgaagg gctacaagga ggtgaagaag gacctgatca ttaagctccc caagtactca     4800

ctcttcgagc tggagaacgg caggaagcgg atgctggctt ccgctggcga gctgcagaag     4860

gggaacgagc tggctctgcc gtccaagtat gtgaacttcc tctacctggc ctcccactac     4920

gagaagctca agggcagccc cgaggacaac gagcagaagc agctgttcgt cgagcagcac     4980

aagcattacc tcgacgagat cattgagcag atttccgagt tctccaagcg cgtgatcctg     5040

gccgacgcga atctggataa ggtcctctcc gcgtacaaca agcaccgcga caagccaatc     5100

agggagcagg ctgagaatat cattcatctc ttcaccctga cgaacctcgg cgcccctgct     5160

gctttcaagt acttcgacac aactatcgat cgcaagaggt acacaagcac taaggaggtc     5220

ctggacgcga ccctcatcca ccagtcgatt accggcctct acgagacgcg catcgacctg     5280

tctcagctcg ggggcgactc cggcggcagc ccaaagaaga agcggaaggt gtctggaggt     5340

tctcctaaga aaaagagaaa agtgtccggc ggctccccga agaagaagcg caaggtgtag     5400


<210>  33
<211>  1793
<212>  PRT
<213>  artificial sequence

<220>
<223>  PABE-1

<400>  33

Met Pro Lys Lys Lys Arg Lys Val Ser Gly Gly Ser Ser Glu Val Glu 
1               5                   10                  15      


Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg 
            20                  25                  30          


Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn 
        35                  40                  45              


Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp 
    50                  55                  60                  


Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val 
65                  70                  75                  80  


Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Leu Glu 
                85                  90                  95      


Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg 
            100                 105                 110         


Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu 
        115                 120                 125             


Met Asp Val Leu His His Pro Gly Met Asn His Arg Val Glu Ile Thr 
    130                 135                 140                 


Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe 
145                 150                 155                 160 


Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys Lys Ala Gln Ser Ser 
                165                 170                 175     


Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro 
            180                 185                 190         


Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly 
        195                 200                 205             


Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala 
    210                 215                 220                 


Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg Glu Val Pro Val Gly 
225                 230                 235                 240 


Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg 
                245                 250                 255     


Ala Ile Gly Leu His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu 
            260                 265                 270         


Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr 
        275                 280                 285             


Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile 
    290                 295                 300                 


His Ser Arg Ile Gly Arg Val Val Phe Gly Val Arg Asn Ala Lys Thr 
305                 310                 315                 320 


Gly Ala Ala Gly Ser Leu Met Asp Val Leu His Tyr Pro Gly Met Asn 
                325                 330                 335     


His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala 
            340                 345                 350         


Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln Val Phe Asn Ala Gln 
        355                 360                 365             


Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser 
    370                 375                 380                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
385                 390                 395                 400 


Ser Gly Gly Ser Ser Gly Gly Ser Leu Lys Asp Lys Lys Tyr Ser Ile 
                405                 410                 415     


Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
            420                 425                 430         


Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp 
        435                 440                 445             


Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser 
    450                 455                 460                 


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
465                 470                 475                 480 


Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser 
                485                 490                 495     


Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu 
            500                 505                 510         


Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe 
        515                 520                 525             


Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile 
    530                 535                 540                 


Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu 
545                 550                 555                 560 


Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His 
                565                 570                 575     


Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys 
            580                 585                 590         


Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn 
        595                 600                 605             


Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg 
    610                 615                 620                 


Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly 
625                 630                 635                 640 


Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly 
                645                 650                 655     


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys 
            660                 665                 670         


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu 
        675                 680                 685             


Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn 
    690                 695                 700                 


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu 
705                 710                 715                 720 


Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu 
                725                 730                 735     


His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu 
            740                 745                 750         


Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr 
        755                 760                 765             


Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe 
    770                 775                 780                 


Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val 
785                 790                 795                 800 


Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn 
                805                 810                 815     


Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu 
            820                 825                 830         


Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys 
        835                 840                 845             


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
    850                 855                 860                 


Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu 
865                 870                 875                 880 


Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser 
                885                 890                 895     


Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro 
            900                 905                 910         


Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr 
        915                 920                 925             


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg 
    930                 935                 940                 


Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu 
945                 950                 955                 960 


Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp 
                965                 970                 975     


Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val 
            980                 985                 990         


Glu Asp Arg Phe Asn Ala Ser Leu  Gly Thr Tyr His Asp  Leu Leu Lys 
        995                 1000                 1005             


Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn Glu Glu  Asn Glu Asp 
    1010                 1015                 1020             


Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr Leu Phe  Glu Asp Arg 
    1025                 1030                 1035             


Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr Ala His  Leu Phe Asp 
    1040                 1045                 1050             


Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg Arg Tyr  Thr Gly Trp 
    1055                 1060                 1065             


Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly Ile Arg  Asp Lys Gln 
    1070                 1075                 1080             


Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys Ser Asp  Gly Phe Ala 
    1085                 1090                 1095             


Asn Arg  Asn Phe Met Gln Leu  Ile His Asp Asp Ser  Leu Thr Phe 
    1100                 1105                 1110             


Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser Gly Gln  Gly Asp Ser 
    1115                 1120                 1125             


Leu His  Glu His Ile Ala Asn  Leu Ala Gly Ser Pro  Ala Ile Lys 
    1130                 1135                 1140             


Lys Gly  Ile Leu Gln Thr Val  Lys Val Val Asp Glu  Leu Val Lys 
    1145                 1150                 1155             


Val Met  Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
    1160                 1165                 1170             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1175                 1180                 1185             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1190                 1195                 1200             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1205                 1210                 1215             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1220                 1225                 1230             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1235                 1240                 1245             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1250                 1255                 1260             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1265                 1270                 1275             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1280                 1285                 1290             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1295                 1300                 1305             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1310                 1315                 1320             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1325                 1330                 1335             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1340                 1345                 1350             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1355                 1360                 1365             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1370                 1375                 1380             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1385                 1390                 1395             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1400                 1405                 1410             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1415                 1420                 1425             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1430                 1435                 1440             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1445                 1450                 1455             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1460                 1465                 1470             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1475                 1480                 1485             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1490                 1495                 1500             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1505                 1510                 1515             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1520                 1525                 1530             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1535                 1540                 1545             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1550                 1555                 1560             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1565                 1570                 1575             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1580                 1585                 1590             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1595                 1600                 1605             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1610                 1615                 1620             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1625                 1630                 1635             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1640                 1645                 1650             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1655                 1660                 1665             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1670                 1675                 1680             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1685                 1690                 1695             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1700                 1705                 1710             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1715                 1720                 1725             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1730                 1735                 1740             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1745                 1750                 1755             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1760                 1765                 1770             


Leu Gly  Gly Asp Lys Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln 
    1775                 1780                 1785             


Ala Lys  Lys Lys Lys 
    1790             


<210>  34
<211>  1777
<212>  PRT
<213>  artificial sequence

<220>
<223>  PABE-2

<400>  34

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Leu Lys Asp 
385                 390                 395                 400 


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
                405                 410                 415     


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
            420                 425                 430         


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
        435                 440                 445             


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
    450                 455                 460                 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
465                 470                 475                 480 


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
                485                 490                 495     


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
            500                 505                 510         


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
        515                 520                 525             


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
    530                 535                 540                 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
545                 550                 555                 560 


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
                565                 570                 575     


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
            580                 585                 590         


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
        595                 600                 605             


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
    610                 615                 620                 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
625                 630                 635                 640 


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
                645                 650                 655     


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
            660                 665                 670         


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
        675                 680                 685             


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
    690                 695                 700                 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
705                 710                 715                 720 


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
                725                 730                 735     


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
            740                 745                 750         


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
        755                 760                 765             


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
    770                 775                 780                 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
785                 790                 795                 800 


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
                805                 810                 815     


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
            820                 825                 830         


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
        835                 840                 845             


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
    850                 855                 860                 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
865                 870                 875                 880 


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
                885                 890                 895     


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
            900                 905                 910         


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
        915                 920                 925             


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
    930                 935                 940                 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
945                 950                 955                 960 


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
                965                 970                 975     


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
            980                 985                 990         


His Asp Leu Leu Lys Ile Ile Lys  Asp Lys Asp Phe Leu  Asp Asn Glu 
        995                 1000                 1005             


Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val Leu Thr  Leu Thr Leu 
    1010                 1015                 1020             


Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg Leu Lys  Thr Tyr Ala 
    1025                 1030                 1035             


His Leu  Phe Asp Asp Lys Val  Met Lys Gln Leu Lys  Arg Arg Arg 
    1040                 1045                 1050             


Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys Leu Ile  Asn Gly Ile 
    1055                 1060                 1065             


Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu Asp Phe  Leu Lys Ser 
    1070                 1075                 1080             


Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln Leu Ile  His Asp Asp 
    1085                 1090                 1095             


Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys Ala Gln  Val Ser Gly 
    1100                 1105                 1110             


Gln Gly  Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
    1115                 1120                 1125             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1145                 1150                 1155             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1160                 1165                 1170             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1175                 1180                 1185             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1190                 1195                 1200             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1205                 1210                 1215             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1220                 1225                 1230             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1235                 1240                 1245             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1250                 1255                 1260             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1265                 1270                 1275             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1280                 1285                 1290             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1295                 1300                 1305             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1310                 1315                 1320             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1325                 1330                 1335             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1340                 1345                 1350             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1355                 1360                 1365             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1370                 1375                 1380             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1385                 1390                 1395             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1400                 1405                 1410             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1415                 1420                 1425             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1430                 1435                 1440             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1445                 1450                 1455             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1460                 1465                 1470             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1475                 1480                 1485             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1490                 1495                 1500             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1505                 1510                 1515             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1520                 1525                 1530             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1535                 1540                 1545             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1550                 1555                 1560             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1565                 1570                 1575             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1580                 1585                 1590             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1595                 1600                 1605             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1610                 1615                 1620             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1625                 1630                 1635             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1640                 1645                 1650             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1655                 1660                 1665             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1670                 1675                 1680             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1685                 1690                 1695             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1700                 1705                 1710             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1715                 1720                 1725             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1730                 1735                 1740             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1745                 1750                 1755             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Pro Lys Lys 
    1760                 1765                 1770             


Lys Arg  Lys Val 
    1775         


<210>  35
<211>  1793
<212>  PRT
<213>  artificial sequence

<220>
<223>  PABE-3

<400>  35

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Leu Lys Pro 
385                 390                 395                 400 


Lys Lys Lys Arg Lys Val Ser Gly Gly Ser Asp Lys Lys Tyr Ser Ile 
                405                 410                 415     


Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp 
            420                 425                 430         


Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp 
        435                 440                 445             


Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser 
    450                 455                 460                 


Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg 
465                 470                 475                 480 


Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser 
                485                 490                 495     


Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu 
            500                 505                 510         


Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe 
        515                 520                 525             


Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile 
    530                 535                 540                 


Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu 
545                 550                 555                 560 


Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His 
                565                 570                 575     


Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys 
            580                 585                 590         


Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn 
        595                 600                 605             


Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg 
    610                 615                 620                 


Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly 
625                 630                 635                 640 


Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly 
                645                 650                 655     


Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys 
            660                 665                 670         


Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu 
        675                 680                 685             


Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn 
    690                 695                 700                 


Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu 
705                 710                 715                 720 


Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu 
                725                 730                 735     


His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu 
            740                 745                 750         


Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr 
        755                 760                 765             


Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe 
    770                 775                 780                 


Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val 
785                 790                 795                 800 


Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn 
                805                 810                 815     


Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu 
            820                 825                 830         


Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys 
        835                 840                 845             


Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu 
    850                 855                 860                 


Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu 
865                 870                 875                 880 


Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser 
                885                 890                 895     


Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro 
            900                 905                 910         


Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr 
        915                 920                 925             


Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg 
    930                 935                 940                 


Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu 
945                 950                 955                 960 


Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp 
                965                 970                 975     


Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val 
            980                 985                 990         


Glu Asp Arg Phe Asn Ala Ser Leu  Gly Thr Tyr His Asp  Leu Leu Lys 
        995                 1000                 1005             


Ile Ile  Lys Asp Lys Asp Phe  Leu Asp Asn Glu Glu  Asn Glu Asp 
    1010                 1015                 1020             


Ile Leu  Glu Asp Ile Val Leu  Thr Leu Thr Leu Phe  Glu Asp Arg 
    1025                 1030                 1035             


Glu Met  Ile Glu Glu Arg Leu  Lys Thr Tyr Ala His  Leu Phe Asp 
    1040                 1045                 1050             


Asp Lys  Val Met Lys Gln Leu  Lys Arg Arg Arg Tyr  Thr Gly Trp 
    1055                 1060                 1065             


Gly Arg  Leu Ser Arg Lys Leu  Ile Asn Gly Ile Arg  Asp Lys Gln 
    1070                 1075                 1080             


Ser Gly  Lys Thr Ile Leu Asp  Phe Leu Lys Ser Asp  Gly Phe Ala 
    1085                 1090                 1095             


Asn Arg  Asn Phe Met Gln Leu  Ile His Asp Asp Ser  Leu Thr Phe 
    1100                 1105                 1110             


Lys Glu  Asp Ile Gln Lys Ala  Gln Val Ser Gly Gln  Gly Asp Ser 
    1115                 1120                 1125             


Leu His  Glu His Ile Ala Asn  Leu Ala Gly Ser Pro  Ala Ile Lys 
    1130                 1135                 1140             


Lys Gly  Ile Leu Gln Thr Val  Lys Val Val Asp Glu  Leu Val Lys 
    1145                 1150                 1155             


Val Met  Gly Arg His Lys Pro  Glu Asn Ile Val Ile  Glu Met Ala 
    1160                 1165                 1170             


Arg Glu  Asn Gln Thr Thr Gln  Lys Gly Gln Lys Asn  Ser Arg Glu 
    1175                 1180                 1185             


Arg Met  Lys Arg Ile Glu Glu  Gly Ile Lys Glu Leu  Gly Ser Gln 
    1190                 1195                 1200             


Ile Leu  Lys Glu His Pro Val  Glu Asn Thr Gln Leu  Gln Asn Glu 
    1205                 1210                 1215             


Lys Leu  Tyr Leu Tyr Tyr Leu  Gln Asn Gly Arg Asp  Met Tyr Val 
    1220                 1225                 1230             


Asp Gln  Glu Leu Asp Ile Asn  Arg Leu Ser Asp Tyr  Asp Val Asp 
    1235                 1240                 1245             


His Ile  Val Pro Gln Ser Phe  Leu Lys Asp Asp Ser  Ile Asp Asn 
    1250                 1255                 1260             


Lys Val  Leu Thr Arg Ser Asp  Lys Asn Arg Gly Lys  Ser Asp Asn 
    1265                 1270                 1275             


Val Pro  Ser Glu Glu Val Val  Lys Lys Met Lys Asn  Tyr Trp Arg 
    1280                 1285                 1290             


Gln Leu  Leu Asn Ala Lys Leu  Ile Thr Gln Arg Lys  Phe Asp Asn 
    1295                 1300                 1305             


Leu Thr  Lys Ala Glu Arg Gly  Gly Leu Ser Glu Leu  Asp Lys Ala 
    1310                 1315                 1320             


Gly Phe  Ile Lys Arg Gln Leu  Val Glu Thr Arg Gln  Ile Thr Lys 
    1325                 1330                 1335             


His Val  Ala Gln Ile Leu Asp  Ser Arg Met Asn Thr  Lys Tyr Asp 
    1340                 1345                 1350             


Glu Asn  Asp Lys Leu Ile Arg  Glu Val Lys Val Ile  Thr Leu Lys 
    1355                 1360                 1365             


Ser Lys  Leu Val Ser Asp Phe  Arg Lys Asp Phe Gln  Phe Tyr Lys 
    1370                 1375                 1380             


Val Arg  Glu Ile Asn Asn Tyr  His His Ala His Asp  Ala Tyr Leu 
    1385                 1390                 1395             


Asn Ala  Val Val Gly Thr Ala  Leu Ile Lys Lys Tyr  Pro Lys Leu 
    1400                 1405                 1410             


Glu Ser  Glu Phe Val Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg 
    1415                 1420                 1425             


Lys Met  Ile Ala Lys Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala 
    1430                 1435                 1440             


Lys Tyr  Phe Phe Tyr Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu 
    1445                 1450                 1455             


Ile Thr  Leu Ala Asn Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu 
    1460                 1465                 1470             


Thr Asn  Gly Glu Thr Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp 
    1475                 1480                 1485             


Phe Ala  Thr Val Arg Lys Val  Leu Ser Met Pro Gln  Val Asn Ile 
    1490                 1495                 1500             


Val Lys  Lys Thr Glu Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser 
    1505                 1510                 1515             


Ile Leu  Pro Lys Arg Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys 
    1520                 1525                 1530             


Asp Trp  Asp Pro Lys Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val 
    1535                 1540                 1545             


Ala Tyr  Ser Val Leu Val Val  Ala Lys Val Glu Lys  Gly Lys Ser 
    1550                 1555                 1560             


Lys Lys  Leu Lys Ser Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met 
    1565                 1570                 1575             


Glu Arg  Ser Ser Phe Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala 
    1580                 1585                 1590             


Lys Gly  Tyr Lys Glu Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro 
    1595                 1600                 1605             


Lys Tyr  Ser Leu Phe Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu 
    1610                 1615                 1620             


Ala Ser  Ala Gly Glu Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro 
    1625                 1630                 1635             


Ser Lys  Tyr Val Asn Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys 
    1640                 1645                 1650             


Leu Lys  Gly Ser Pro Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val 
    1655                 1660                 1665             


Glu Gln  His Lys His Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser 
    1670                 1675                 1680             


Glu Phe  Ser Lys Arg Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys 
    1685                 1690                 1695             


Val Leu  Ser Ala Tyr Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu 
    1700                 1705                 1710             


Gln Ala  Glu Asn Ile Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly 
    1715                 1720                 1725             


Ala Pro  Ala Ala Phe Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys 
    1730                 1735                 1740             


Arg Tyr  Thr Ser Thr Lys Glu  Val Leu Asp Ala Thr  Leu Ile His 
    1745                 1750                 1755             


Gln Ser  Ile Thr Gly Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln 
    1760                 1765                 1770             


Leu Gly  Gly Asp Lys Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln 
    1775                 1780                 1785             


Ala Lys  Lys Lys Lys 
    1790             


<210>  36
<211>  1793
<212>  PRT
<213>  artificial sequence

<220>
<223>  PABE-4

<400>  36

Met Pro Lys Lys Lys Arg Lys Val Ser Gly Gly Ser Asp Lys Lys Tyr 
1               5                   10                  15      


Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile 
            20                  25                  30          


Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn 
        35                  40                  45              


Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe 
    50                  55                  60                  


Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg 
65                  70                  75                  80  


Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile 
                85                  90                  95      


Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu 
            100                 105                 110         


Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro 
        115                 120                 125             


Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro 
    130                 135                 140                 


Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala 
145                 150                 155                 160 


Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg 
                165                 170                 175     


Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val 
            180                 185                 190         


Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu 
        195                 200                 205             


Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser 
    210                 215                 220                 


Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu 
225                 230                 235                 240 


Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser 
                245                 250                 255     


Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp 
            260                 265                 270         


Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn 
        275                 280                 285             


Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala 
    290                 295                 300                 


Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn 
305                 310                 315                 320 


Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr 
                325                 330                 335     


Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln 
            340                 345                 350         


Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn 
        355                 360                 365             


Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr 
    370                 375                 380                 


Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu 
385                 390                 395                 400 


Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe 
                405                 410                 415     


Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala 
            420                 425                 430         


Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg 
        435                 440                 445             


Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly 
    450                 455                 460                 


Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser 
465                 470                 475                 480 


Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly 
                485                 490                 495     


Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn 
            500                 505                 510         


Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr 
        515                 520                 525             


Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly 
    530                 535                 540                 


Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val 
545                 550                 555                 560 


Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys 
                565                 570                 575     


Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser 
            580                 585                 590         


Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu 
        595                 600                 605             


Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu 
    610                 615                 620                 


Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg 
625                 630                 635                 640 


Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp 
                645                 650                 655     


Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg 
            660                 665                 670         


Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys 
        675                 680                 685             


Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe 
    690                 695                 700                 


Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln 
705                 710                 715                 720 


Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala 
                725                 730                 735     


Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val 
            740                 745                 750         


Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu 
        755                 760                 765             


Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly 
    770                 775                 780                 


Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys 
785                 790                 795                 800 


Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln 
                805                 810                 815     


Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp 
            820                 825                 830         


Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp 
        835                 840                 845             


Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp 
    850                 855                 860                 


Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn 
865                 870                 875                 880 


Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln 
                885                 890                 895     


Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr 
            900                 905                 910         


Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile 
        915                 920                 925             


Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln 
    930                 935                 940                 


Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu 
945                 950                 955                 960 


Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp 
                965                 970                 975     


Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr 
            980                 985                 990         


His His Ala His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
        995                 1000                 1005             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1010                 1015                 1020             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1025                 1030                 1035             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1040                 1045                 1050             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1055                 1060                 1065             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1070                 1075                 1080             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1085                 1090                 1095             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1100                 1105                 1110             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp 
    1115                 1120                 1125             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser Val Leu  Val Val Ala 
    1145                 1150                 1155             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    1160                 1165                 1170             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    1175                 1180                 1185             


Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    1190                 1195                 1200             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    1205                 1210                 1215             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys 
    1220                 1225                 1230             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    1235                 1240                 1245             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn 
    1250                 1255                 1260             


Glu Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    1265                 1270                 1275             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    1280                 1285                 1290             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    1295                 1300                 1305             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    1310                 1315                 1320             


Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe 
    1325                 1330                 1335             


Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val 
    1340                 1345                 1350             


Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    1355                 1360                 1365             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Glu  Phe Ser Gly 
    1370                 1375                 1380             


Gly Ser  Ser Gly Gly Ser Ser  Gly Ser Glu Thr Pro  Gly Thr Ser 
    1385                 1390                 1395             


Glu Ser  Ala Thr Pro Glu Ser  Ser Gly Gly Ser Ser  Gly Gly Ser 
    1400                 1405                 1410             


Ser Glu  Val Glu Phe Ser His  Glu Tyr Trp Met Arg  His Ala Leu 
    1415                 1420                 1425             


Thr Leu  Ala Lys Arg Ala Trp  Asp Glu Arg Glu Val  Pro Val Gly 
    1430                 1435                 1440             


Ala Val  Leu Val His Asn Asn  Arg Val Ile Gly Glu  Gly Trp Asn 
    1445                 1450                 1455             


Arg Pro  Ile Gly Arg His Asp  Pro Thr Ala His Ala  Glu Ile Met 
    1460                 1465                 1470             


Ala Leu  Arg Gln Gly Gly Leu  Val Met Gln Asn Tyr  Arg Leu Ile 
    1475                 1480                 1485             


Asp Ala  Thr Leu Tyr Val Thr  Leu Glu Pro Cys Val  Met Cys Ala 
    1490                 1495                 1500             


Gly Ala  Met Ile His Ser Arg  Ile Gly Arg Val Val  Phe Gly Ala 
    1505                 1510                 1515             


Arg Asp  Ala Lys Thr Gly Ala  Ala Gly Ser Leu Met  Asp Val Leu 
    1520                 1525                 1530             


His His  Pro Gly Met Asn His  Arg Val Glu Ile Thr  Glu Gly Ile 
    1535                 1540                 1545             


Leu Ala  Asp Glu Cys Ala Ala  Leu Leu Ser Asp Phe  Phe Arg Met 
    1550                 1555                 1560             


Arg Arg  Gln Glu Ile Lys Ala  Gln Lys Lys Ala Gln  Ser Ser Thr 
    1565                 1570                 1575             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1580                 1585                 1590             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1595                 1600                 1605             


Gly Gly  Ser Ser Glu Val Glu  Phe Ser His Glu Tyr  Trp Met Arg 
    1610                 1615                 1620             


His Ala  Leu Thr Leu Ala Lys  Arg Ala Arg Asp Glu  Arg Glu Val 
    1625                 1630                 1635             


Pro Val  Gly Ala Val Leu Val  Leu Asn Asn Arg Val  Ile Gly Glu 
    1640                 1645                 1650             


Gly Trp  Asn Arg Ala Ile Gly  Leu His Asp Pro Thr  Ala His Ala 
    1655                 1660                 1665             


Glu Ile  Met Ala Leu Arg Gln  Gly Gly Leu Val Met  Gln Asn Tyr 
    1670                 1675                 1680             


Arg Leu  Ile Asp Ala Thr Leu  Tyr Val Thr Phe Glu  Pro Cys Val 
    1685                 1690                 1695             


Met Cys  Ala Gly Ala Met Ile  His Ser Arg Ile Gly  Arg Val Val 
    1700                 1705                 1710             


Phe Gly  Val Arg Asn Ala Lys  Thr Gly Ala Ala Gly  Ser Leu Met 
    1715                 1720                 1725             


Asp Val  Leu His Tyr Pro Gly  Met Asn His Arg Val  Glu Ile Thr 
    1730                 1735                 1740             


Glu Gly  Ile Leu Ala Asp Glu  Cys Ala Ala Leu Leu  Cys Tyr Phe 
    1745                 1750                 1755             


Phe Arg  Met Pro Arg Gln Val  Phe Asn Ala Gln Lys  Lys Ala Gln 
    1760                 1765                 1770             


Ser Ser  Thr Asp Lys Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln 
    1775                 1780                 1785             


Ala Lys  Lys Lys Lys 
    1790             


<210>  37
<211>  1802
<212>  PRT
<213>  artificial sequence

<220>
<223>  PABE-5

<400>  37

Met Pro Lys Lys Lys Arg Lys Val Ser Gly Gly Ser Asp Lys Lys Tyr 
1               5                   10                  15      


Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile 
            20                  25                  30          


Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn 
        35                  40                  45              


Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe 
    50                  55                  60                  


Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg 
65                  70                  75                  80  


Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile 
                85                  90                  95      


Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu 
            100                 105                 110         


Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro 
        115                 120                 125             


Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro 
    130                 135                 140                 


Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala 
145                 150                 155                 160 


Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg 
                165                 170                 175     


Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val 
            180                 185                 190         


Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu 
        195                 200                 205             


Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser 
    210                 215                 220                 


Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu 
225                 230                 235                 240 


Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser 
                245                 250                 255     


Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp 
            260                 265                 270         


Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn 
        275                 280                 285             


Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala 
    290                 295                 300                 


Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn 
305                 310                 315                 320 


Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr 
                325                 330                 335     


Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln 
            340                 345                 350         


Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn 
        355                 360                 365             


Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr 
    370                 375                 380                 


Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu 
385                 390                 395                 400 


Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe 
                405                 410                 415     


Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala 
            420                 425                 430         


Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg 
        435                 440                 445             


Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly 
    450                 455                 460                 


Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser 
465                 470                 475                 480 


Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly 
                485                 490                 495     


Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn 
            500                 505                 510         


Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr 
        515                 520                 525             


Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly 
    530                 535                 540                 


Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val 
545                 550                 555                 560 


Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys 
                565                 570                 575     


Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser 
            580                 585                 590         


Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu 
        595                 600                 605             


Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu 
    610                 615                 620                 


Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg 
625                 630                 635                 640 


Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp 
                645                 650                 655     


Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg 
            660                 665                 670         


Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys 
        675                 680                 685             


Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe 
    690                 695                 700                 


Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln 
705                 710                 715                 720 


Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala 
                725                 730                 735     


Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val 
            740                 745                 750         


Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu 
        755                 760                 765             


Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly 
    770                 775                 780                 


Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys 
785                 790                 795                 800 


Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln 
                805                 810                 815     


Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp 
            820                 825                 830         


Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp 
        835                 840                 845             


Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp 
    850                 855                 860                 


Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn 
865                 870                 875                 880 


Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln 
                885                 890                 895     


Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr 
            900                 905                 910         


Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile 
        915                 920                 925             


Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln 
    930                 935                 940                 


Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu 
945                 950                 955                 960 


Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp 
                965                 970                 975     


Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr 
            980                 985                 990         


His His Ala His Asp Ala Tyr Leu  Asn Ala Val Val Gly  Thr Ala Leu 
        995                 1000                 1005             


Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu Phe Val  Tyr Gly Asp 
    1010                 1015                 1020             


Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile Ala Lys  Ser Glu Gln 
    1025                 1030                 1035             


Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe Phe Tyr  Ser Asn Ile 
    1040                 1045                 1050             


Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu Ala Asn  Gly Glu Ile 
    1055                 1060                 1065             


Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly Glu Thr  Gly Glu Ile 
    1070                 1075                 1080             


Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr Val Arg  Lys Val Leu 
    1085                 1090                 1095             


Ser Met  Pro Gln Val Asn Ile  Val Lys Lys Thr Glu  Val Gln Thr 
    1100                 1105                 1110             


Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro Lys Arg  Asn Ser Asp 
    1115                 1120                 1125             


Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp Pro Lys  Lys Tyr Gly 
    1130                 1135                 1140             


Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser Val Leu  Val Val Ala 
    1145                 1150                 1155             


Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu Lys Ser  Val Lys Glu 
    1160                 1165                 1170             


Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser Ser Phe  Glu Lys Asn 
    1175                 1180                 1185             


Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr Lys Glu  Val Lys Lys 
    1190                 1195                 1200             


Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser Leu Phe  Glu Leu Glu 
    1205                 1210                 1215             


Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala Gly Glu  Leu Gln Lys 
    1220                 1225                 1230             


Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr Val Asn  Phe Leu Tyr 
    1235                 1240                 1245             


Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly Ser Pro  Glu Asp Asn 
    1250                 1255                 1260             


Glu Gln  Lys Gln Leu Phe Val  Glu Gln His Lys His  Tyr Leu Asp 
    1265                 1270                 1275             


Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser Lys Arg  Val Ile Leu 
    1280                 1285                 1290             


Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser Ala Tyr  Asn Lys His 
    1295                 1300                 1305             


Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu Asn Ile  Ile His Leu 
    1310                 1315                 1320             


Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala Ala Phe  Lys Tyr Phe 
    1325                 1330                 1335             


Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr Ser Thr  Lys Glu Val 
    1340                 1345                 1350             


Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile Thr Gly  Leu Tyr Glu 
    1355                 1360                 1365             


Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly Asp Glu  Phe Pro Lys 
    1370                 1375                 1380             


Lys Lys  Arg Lys Val Glu Phe  Ser Gly Gly Ser Ser  Gly Gly Ser 
    1385                 1390                 1395             


Ser Gly  Ser Glu Thr Pro Gly  Thr Ser Glu Ser Ala  Thr Pro Glu 
    1400                 1405                 1410             


Ser Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Glu Val  Glu Phe Ser 
    1415                 1420                 1425             


His Glu  Tyr Trp Met Arg His  Ala Leu Thr Leu Ala  Lys Arg Ala 
    1430                 1435                 1440             


Trp Asp  Glu Arg Glu Val Pro  Val Gly Ala Val Leu  Val His Asn 
    1445                 1450                 1455             


Asn Arg  Val Ile Gly Glu Gly  Trp Asn Arg Pro Ile  Gly Arg His 
    1460                 1465                 1470             


Asp Pro  Thr Ala His Ala Glu  Ile Met Ala Leu Arg  Gln Gly Gly 
    1475                 1480                 1485             


Leu Val  Met Gln Asn Tyr Arg  Leu Ile Asp Ala Thr  Leu Tyr Val 
    1490                 1495                 1500             


Thr Leu  Glu Pro Cys Val Met  Cys Ala Gly Ala Met  Ile His Ser 
    1505                 1510                 1515             


Arg Ile  Gly Arg Val Val Phe  Gly Ala Arg Asp Ala  Lys Thr Gly 
    1520                 1525                 1530             


Ala Ala  Gly Ser Leu Met Asp  Val Leu His His Pro  Gly Met Asn 
    1535                 1540                 1545             


His Arg  Val Glu Ile Thr Glu  Gly Ile Leu Ala Asp  Glu Cys Ala 
    1550                 1555                 1560             


Ala Leu  Leu Ser Asp Phe Phe  Arg Met Arg Arg Gln  Glu Ile Lys 
    1565                 1570                 1575             


Ala Gln  Lys Lys Ala Gln Ser  Ser Thr Asp Ser Gly  Gly Ser Ser 
    1580                 1585                 1590             


Gly Gly  Ser Ser Gly Ser Glu  Thr Pro Gly Thr Ser  Glu Ser Ala 
    1595                 1600                 1605             


Thr Pro  Glu Ser Ser Gly Gly  Ser Ser Gly Gly Ser  Ser Glu Val 
    1610                 1615                 1620             


Glu Phe  Ser His Glu Tyr Trp  Met Arg His Ala Leu  Thr Leu Ala 
    1625                 1630                 1635             


Lys Arg  Ala Arg Asp Glu Arg  Glu Val Pro Val Gly  Ala Val Leu 
    1640                 1645                 1650             


Val Leu  Asn Asn Arg Val Ile  Gly Glu Gly Trp Asn  Arg Ala Ile 
    1655                 1660                 1665             


Gly Leu  His Asp Pro Thr Ala  His Ala Glu Ile Met  Ala Leu Arg 
    1670                 1675                 1680             


Gln Gly  Gly Leu Val Met Gln  Asn Tyr Arg Leu Ile  Asp Ala Thr 
    1685                 1690                 1695             


Leu Tyr  Val Thr Phe Glu Pro  Cys Val Met Cys Ala  Gly Ala Met 
    1700                 1705                 1710             


Ile His  Ser Arg Ile Gly Arg  Val Val Phe Gly Val  Arg Asn Ala 
    1715                 1720                 1725             


Lys Thr  Gly Ala Ala Gly Ser  Leu Met Asp Val Leu  His Tyr Pro 
    1730                 1735                 1740             


Gly Met  Asn His Arg Val Glu  Ile Thr Glu Gly Ile  Leu Ala Asp 
    1745                 1750                 1755             


Glu Cys  Ala Ala Leu Leu Cys  Tyr Phe Phe Arg Met  Pro Arg Gln 
    1760                 1765                 1770             


Val Phe  Asn Ala Gln Lys Lys  Ala Gln Ser Ser Thr  Asp Lys Arg 
    1775                 1780                 1785             


Pro Ala  Ala Thr Lys Lys Ala  Gly Gln Ala Lys Lys  Lys Lys 
    1790                 1795                 1800         


<210>  38
<211>  1788
<212>  PRT
<213>  artificial sequence

<220>
<223>  PABE-6

<400>  38

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Leu Lys Asp 
385                 390                 395                 400 


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
                405                 410                 415     


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
            420                 425                 430         


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
        435                 440                 445             


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
    450                 455                 460                 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
465                 470                 475                 480 


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
                485                 490                 495     


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
            500                 505                 510         


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
        515                 520                 525             


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
    530                 535                 540                 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
545                 550                 555                 560 


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
                565                 570                 575     


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
            580                 585                 590         


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
        595                 600                 605             


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
    610                 615                 620                 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
625                 630                 635                 640 


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
                645                 650                 655     


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
            660                 665                 670         


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
        675                 680                 685             


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
    690                 695                 700                 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
705                 710                 715                 720 


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
                725                 730                 735     


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
            740                 745                 750         


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
        755                 760                 765             


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
    770                 775                 780                 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
785                 790                 795                 800 


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
                805                 810                 815     


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
            820                 825                 830         


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
        835                 840                 845             


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
    850                 855                 860                 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
865                 870                 875                 880 


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
                885                 890                 895     


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
            900                 905                 910         


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
        915                 920                 925             


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
    930                 935                 940                 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
945                 950                 955                 960 


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
                965                 970                 975     


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
            980                 985                 990         


His Asp Leu Leu Lys Ile Ile Lys  Asp Lys Asp Phe Leu  Asp Asn Glu 
        995                 1000                 1005             


Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val Leu Thr  Leu Thr Leu 
    1010                 1015                 1020             


Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg Leu Lys  Thr Tyr Ala 
    1025                 1030                 1035             


His Leu  Phe Asp Asp Lys Val  Met Lys Gln Leu Lys  Arg Arg Arg 
    1040                 1045                 1050             


Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys Leu Ile  Asn Gly Ile 
    1055                 1060                 1065             


Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu Asp Phe  Leu Lys Ser 
    1070                 1075                 1080             


Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln Leu Ile  His Asp Asp 
    1085                 1090                 1095             


Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys Ala Gln  Val Ser Gly 
    1100                 1105                 1110             


Gln Gly  Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
    1115                 1120                 1125             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1145                 1150                 1155             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1160                 1165                 1170             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1175                 1180                 1185             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1190                 1195                 1200             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1205                 1210                 1215             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1220                 1225                 1230             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1235                 1240                 1245             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1250                 1255                 1260             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1265                 1270                 1275             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1280                 1285                 1290             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1295                 1300                 1305             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1310                 1315                 1320             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1325                 1330                 1335             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1340                 1345                 1350             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1355                 1360                 1365             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1370                 1375                 1380             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1385                 1390                 1395             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1400                 1405                 1410             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1415                 1420                 1425             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1430                 1435                 1440             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1445                 1450                 1455             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1460                 1465                 1470             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1475                 1480                 1485             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1490                 1495                 1500             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1505                 1510                 1515             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1520                 1525                 1530             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1535                 1540                 1545             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1550                 1555                 1560             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1565                 1570                 1575             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1580                 1585                 1590             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1595                 1600                 1605             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1610                 1615                 1620             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1625                 1630                 1635             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1640                 1645                 1650             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1655                 1660                 1665             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1670                 1675                 1680             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1685                 1690                 1695             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1700                 1705                 1710             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1715                 1720                 1725             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1730                 1735                 1740             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1745                 1750                 1755             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Pro Lys Lys 
    1760                 1765                 1770             


Lys Arg  Lys Val Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1775                 1780                 1785             


<210>  39
<211>  1799
<212>  PRT
<213>  artificial sequence

<220>
<223>  PABE-7

<400>  39

Met Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu 
1               5                   10                  15      


Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala 
            20                  25                  30          


Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro 
        35                  40                  45              


Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg 
    50                  55                  60                  


Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu 
65                  70                  75                  80  


Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His 
                85                  90                  95      


Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly 
            100                 105                 110         


Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His 
        115                 120                 125             


Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu 
    130                 135                 140                 


Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln Lys 
145                 150                 155                 160 


Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                165                 170                 175     


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
            180                 185                 190         


Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu Tyr 
        195                 200                 205             


Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu Arg 
    210                 215                 220                 


Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile Gly 
225                 230                 235                 240 


Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His Ala 
                245                 250                 255     


Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg 
            260                 265                 270         


Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met Cys 
        275                 280                 285             


Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Val 
    290                 295                 300                 


Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His 
305                 310                 315                 320 


Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala 
                325                 330                 335     


Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg Gln 
            340                 345                 350         


Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
    370                 375                 380                 


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Leu Lys Asp 
385                 390                 395                 400 


Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly Trp 
                405                 410                 415     


Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val 
            420                 425                 430         


Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala 
        435                 440                 445             


Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg 
    450                 455                 460                 


Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu 
465                 470                 475                 480 


Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe 
                485                 490                 495     


His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu 
            500                 505                 510         


Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu 
        515                 520                 525             


Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr 
    530                 535                 540                 


Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile 
545                 550                 555                 560 


Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn 
                565                 570                 575     


Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln 
            580                 585                 590         


Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala 
        595                 600                 605             


Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile 
    610                 615                 620                 


Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile 
625                 630                 635                 640 


Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu 
                645                 650                 655     


Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp 
            660                 665                 670         


Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe 
        675                 680                 685             


Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu 
    690                 695                 700                 


Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile 
705                 710                 715                 720 


Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu 
                725                 730                 735     


Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln 
            740                 745                 750         


Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu 
        755                 760                 765             


Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr 
    770                 775                 780                 


Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln 
785                 790                 795                 800 


Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu 
                805                 810                 815     


Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys 
            820                 825                 830         


Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr 
        835                 840                 845             


Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr 
    850                 855                 860                 


Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val 
865                 870                 875                 880 


Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe 
                885                 890                 895     


Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu 
            900                 905                 910         


Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val 
        915                 920                 925             


Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys 
    930                 935                 940                 


Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys 
945                 950                 955                 960 


Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val 
                965                 970                 975     


Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr 
            980                 985                 990         


His Asp Leu Leu Lys Ile Ile Lys  Asp Lys Asp Phe Leu  Asp Asn Glu 
        995                 1000                 1005             


Glu Asn  Glu Asp Ile Leu Glu  Asp Ile Val Leu Thr  Leu Thr Leu 
    1010                 1015                 1020             


Phe Glu  Asp Arg Glu Met Ile  Glu Glu Arg Leu Lys  Thr Tyr Ala 
    1025                 1030                 1035             


His Leu  Phe Asp Asp Lys Val  Met Lys Gln Leu Lys  Arg Arg Arg 
    1040                 1045                 1050             


Tyr Thr  Gly Trp Gly Arg Leu  Ser Arg Lys Leu Ile  Asn Gly Ile 
    1055                 1060                 1065             


Arg Asp  Lys Gln Ser Gly Lys  Thr Ile Leu Asp Phe  Leu Lys Ser 
    1070                 1075                 1080             


Asp Gly  Phe Ala Asn Arg Asn  Phe Met Gln Leu Ile  His Asp Asp 
    1085                 1090                 1095             


Ser Leu  Thr Phe Lys Glu Asp  Ile Gln Lys Ala Gln  Val Ser Gly 
    1100                 1105                 1110             


Gln Gly  Asp Ser Leu His Glu  His Ile Ala Asn Leu  Ala Gly Ser 
    1115                 1120                 1125             


Pro Ala  Ile Lys Lys Gly Ile  Leu Gln Thr Val Lys  Val Val Asp 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Gly  Arg His Lys Pro Glu  Asn Ile Val 
    1145                 1150                 1155             


Ile Glu  Met Ala Arg Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys 
    1160                 1165                 1170             


Asn Ser  Arg Glu Arg Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu 
    1175                 1180                 1185             


Leu Gly  Ser Gln Ile Leu Lys  Glu His Pro Val Glu  Asn Thr Gln 
    1190                 1195                 1200             


Leu Gln  Asn Glu Lys Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg 
    1205                 1210                 1215             


Asp Met  Tyr Val Asp Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp 
    1220                 1225                 1230             


Tyr Asp  Val Asp His Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp 
    1235                 1240                 1245             


Ser Ile  Asp Asn Lys Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly 
    1250                 1255                 1260             


Lys Ser  Asp Asn Val Pro Ser  Glu Glu Val Val Lys  Lys Met Lys 
    1265                 1270                 1275             


Asn Tyr  Trp Arg Gln Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg 
    1280                 1285                 1290             


Lys Phe  Asp Asn Leu Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu 
    1295                 1300                 1305             


Leu Asp  Lys Ala Gly Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg 
    1310                 1315                 1320             


Gln Ile  Thr Lys His Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn 
    1325                 1330                 1335             


Thr Lys  Tyr Asp Glu Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val 
    1340                 1345                 1350             


Ile Thr  Leu Lys Ser Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe 
    1355                 1360                 1365             


Gln Phe  Tyr Lys Val Arg Glu  Ile Asn Asn Tyr His  His Ala His 
    1370                 1375                 1380             


Asp Ala  Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
    1385                 1390                 1395             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1400                 1405                 1410             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1415                 1420                 1425             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1430                 1435                 1440             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1445                 1450                 1455             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1460                 1465                 1470             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1475                 1480                 1485             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1490                 1495                 1500             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1505                 1510                 1515             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1520                 1525                 1530             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1535                 1540                 1545             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1550                 1555                 1560             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1565                 1570                 1575             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1580                 1585                 1590             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1595                 1600                 1605             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1610                 1615                 1620             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1625                 1630                 1635             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1640                 1645                 1650             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1655                 1660                 1665             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1670                 1675                 1680             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1685                 1690                 1695             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1700                 1705                 1710             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1715                 1720                 1725             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1730                 1735                 1740             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1745                 1750                 1755             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Gly Gly Ser  Pro Lys Lys 
    1760                 1765                 1770             


Lys Arg  Lys Val Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    1775                 1780                 1785             


Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys Val 
    1790                 1795                 


<210>  40
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  mGFP target sequence

<400>  40
ccttcaccta cggcgtgtag tgc                                               23


<210>  41
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  41
ggcggcacta cacgccgtag gtga                                              24


<210>  42
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  42
aaactcacct acggcgtgta gtgc                                              24


<210>  43
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsALS-T1 target sequence

<400>  43
cccaagtggg ggcgcattca agg                                               23


<210>  44
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  44
ggcgcccaag tgggggcgca ttca                                              24


<210>  45
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  45
aaactgaatg cgcccccact tggg                                              24


<210>  46
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  46
tgcacccaag tgggggcgca ttca                                              24


<210>  47
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  47
aaactgaatg cgcccccact tggg                                              24


<210>  48
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsALS-T2 target sequence

<400>  48
cctcatgaac attcaggagc tgg                                               23


<210>  49
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  49
ggcgcctcat gaacattcag gagc                                              24


<210>  50
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  50
aaacgctcct gaatgttcat gagg                                              24


<210>  51
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  51
tgcacctcat gaacattcag gagc                                              24


<210>  52
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  52
aaacgctcct gaatgttcat gagg                                              24


<210>  53
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsCDC48-T1 target sequence

<400>  53
gctagctttg acataatctc cgg                                               23


<210>  54
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  54
ggcggctagc tttgacataa tctc                                              24


<210>  55
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  55
aaacgagatt atgtcaaagc tagc                                              24


<210>  56
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsCDC48-T2 target sequence

<400>  56
ccaatgcatc cgtgagaaga tgg                                               23


<210>  57
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  57
ggcgccaatg catccgtgag aaga                                              24


<210>  58
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  58
aaactcttct cacggatgca ttgg                                              24


<210>  59
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsCDC48-T3 target sequence

<400>  59
tagcacccat gacaatgaca tgg                                               23


<210>  60
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  60
ggcgtagcac ccatgacaat gaca                                              24


<210>  61
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  61
aaactgtcat tgtcatgggt gcta                                              24


<210>  62
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  62
tgcatagcac ccatgacaat gaca                                              24


<210>  63
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  63
aaactgtcat tgtcatgggt gcta                                              24


<210>  64
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsAAT target sequence

<400>  64
caaggatccc agccccgtga agg                                               23


<210>  65
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  65
ggcgcaagga tcccagcccc gtga                                              24


<210>  66
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  66
aaactcacgg ggctgggatc cttg                                              24


<210>  67
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  67
tgcacaagga tcccagcccc gtga                                              24


<210>  68
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  68
aaactcacgg ggctgggatc cttg                                              24


<210>  69
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsDEP1-T1 target sequence

<400>  69
agcacatgag agaacaatat tgg                                               23


<210>  70
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  70
ggcgagcaca tgagagaaca atat                                              24


<210>  71
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  71
aaacatattg ttctctcatg tgct                                              24


<210>  72
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  72
tgcaagcaca tgagagaaca atat                                              24


<210>  73
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  73
aaacatattg ttctctcatg tgct                                              24


<210>  74
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsDEP1-T2 target sequence

<400>  74
agacaagctt ggccctcttt ggg                                               23


<210>  75
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  75
ggcgagacaa gcttggccct cttt                                              24


<210>  76
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  76
aaacaaagag ggccaagctt gtct                                              24


<210>  77
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  77
tgcaagacaa gcttggccct cttt                                              24


<210>  78
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  78
aaacaaagag ggccaagctt gtct                                              24


<210>  79
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsDEP1-T3 target sequence

<400>  79
atttcaaatg gatctaaaca ggg                                               23


<210>  80
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  80
ggcgatttca aatggatcta aaca                                              24


<210>  81
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  81
aaactgttta gatccatttg aaat                                              24


<210>  82
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsDEP1-T4 target sequence

<400>  82
acagatcttg ccgtcttttt cgg                                               23


<210>  83
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  83
ggcgacagat cttgccgtct tttt                                              24


<210>  84
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  84
aaacaaaaag acggcaagat ctgt                                              24


<210>  85
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsACC-T1 target sequence

<400>  85
cccagaccgc attgagtgct atg                                               23


<210>  86
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  86
ggcgcatagc actcaatgcg gtct                                              24


<210>  87
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  87
aaacagaccg cattgagtgc tatg                                              24


<210>  88
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  88
tgcacatagc actcaatgcg gtct                                              24


<210>  89
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  89
aaacagaccg cattgagtgc tatg                                              24


<210>  90
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsACC-T2 target sequence

<400>  90
tactagtcac acttgcactg tgg                                               23


<210>  91
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  91
ggcgtactag tcacacttgc actg                                              24


<210>  92
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  92
aaaccagtgc aagtgtgact agta                                              24


<210>  93
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsNRT1.1B-T1 target sequence

<400>  93
actagatatc taaaccatta agg                                               23


<210>  94
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  94
ggcgactaga tatctaaacc atta                                              24


<210>  95
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  95
aaactaatgg tttagatatc tagt                                              24


<210>  96
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  96
tgcaactaga tatctaaacc atta                                              24


<210>  97
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  97
aaactaatgg tttagatatc tagt                                              24


<210>  98
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsNRT1.1B-T2 target sequence

<400>  98
ggccatggcg cccgcggcgg cgg                                               23


<210>  99
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  99
ggcgggccat ggcgcccgcg gcgg                                              24


<210>  100
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  100
aaacccgccg cgggcgccat ggcc                                              24


<210>  101
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsEV target sequence

<400>  101
cacacacaca ctagtacctc tgg                                               23


<210>  102
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  102
ggcgcacaca cacactagta cctc                                              24


<210>  103
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  103
aaacgaggta ctagtgtgtg tgtg                                              24


<210>  104
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  104
tgcacacaca cacactagta cctc                                              24


<210>  105
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  105
aaacgaggta ctagtgtgtg tgtg                                              24


<210>  106
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  OsOD target sequence

<400>  106
acacacacac tagtacctct ggg                                               23


<210>  107
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  107
ggcgacacac acactagtac ctct                                              24


<210>  108
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  108
aaacagaggt actagtgtgt gtgt                                              24


<210>  109
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  109
tgcaacacac acactagtac ctct                                              24


<210>  110
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  110
aaacagaggt actagtgtgt gtgt                                              24


<210>  111
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  TaDEP1 target sequence

<400>  111
acgagctaca tttacttgaa ggg                                               23


<210>  112
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  112
cttgacgagc tacatttact tgaa                                              24


<210>  113
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  113
aaacttcaag taaatgtagc tcgt                                              24


<210>  114
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  114
tgcaacgagc tacatttact tgaa                                              24


<210>  115
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  115
aaacttcaag taaatgtagc tcgt                                              24


<210>  116
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  TaEPSPS target sequence

<400>  116
gaggaagtaa agctcttctt ggg                                               23


<210>  117
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  117
cttggaggaa gtaaagctct tctt                                              24


<210>  118
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  118
aaacaagaag agctttactt cctc                                              24


<210>  119
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  119
tgcagaggaa gtaaagctct tctt                                              24


<210>  120
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  120
aaacaagaag agctttactt cctc                                              24


<210>  121
<211>  23
<212>  DNA
<213>  artificial sequence

<220>
<223>  TaGW2 target sequence

<400>  121
cacaagaaaa tccaccagga tgg                                               23


<210>  122
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  122
cttgcacaag aaaatccacc agga                                              24


<210>  123
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  123
aaactcctgg tggattttct tgtg                                              24


<210>  124
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  F

<400>  124
tgcacacaag aaaatccacc agga                                              24


<210>  125
<211>  24
<212>  DNA
<213>  artificial sequence

<220>
<223>  R

<400>  125
aaactcctgg tggattttct tgtg                                              24


<210>  126
<211>  29
<212>  DNA
<213>  artificial sequence

<220>
<223>  F1

<400>  126
atgctcaccc tgttgtttgg tgttacttc                                         29


<210>  127
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  R1

<400>  127
cttctgggcc ttaatctcct gccttct                                           27


<210>  128
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  F2

<400>  128
tccgctacac cagagtcttc tggaggatct ag                                     32


<210>  129
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  R2

<400>  129
gcagatggta gatcgtaggg tacttctcgt gg                                     32


<210>  130
<211>  29
<212>  DNA
<213>  artificial sequence

<220>
<223>  F3

<400>  130
gaagaactac tggcgccagc tcctgaatg                                         29


<210>  131
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  R3

<400>  131
ggcgatcatc ttcctcacat cgtaaacc                                          28


<210>  132
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  F4

<400>  132
tcgacagccc cactgtggcc tactc                                             25


<210>  133
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  R4

<400>  133
ttatatgctc aacacatgag cgaaaccc                                          28


<210>  134
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  F5

<400>  134
gaccaagccc gttattctga c                                                 21


<210>  135
<211>  26
<212>  DNA
<213>  artificial sequence

<220>
<223>  R5

<400>  135
tgaccatgat tacgccaagc ttagac                                            26


<210>  136
<211>  25
<212>  DNA
<213>  artificial sequence

<220>
<223>  F6

<400>  136
tgaaaaagtg gcaccgagtc ggtgc                                             25


<210>  137
<211>  18
<212>  DNA
<213>  artificial sequence

<220>
<223>  R6

<400>  137
ggcgcagcgg tcgggctg                                                     18


<210>  138
<211>  76
<212>  DNA
<213>  artificial sequence

<220>
<223>  sgRNA

<400>  138
gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt       60

ggcaccgagt cggtgc                                                       76


<210>  139
<211>  86
<212>  DNA
<213>  artificial sequence

<220>
<223>  esgRNA

<400>  139
gtttaagagc tatgctggaa acagcatagc aagtttaaat aaggctagtc cgttatcaac       60

ttgaaaaagt ggcaccgagt cggtgc                                            86


