                         SEQUENCE LISTING

<110>  Harbour Biomed (Shanghai) Co., Ltd
 
<120>  ANTI-CTLA-4 ANTIBODIES AND USES THEREOF

<130>  55543 00001

<150>  US62/607917
<151>  2017-12-20

<160>  200     

<170>  PatentIn version 3.5

<210>  1
<211>  1113
<212>  DNA
<213>  Homo Sapiens

<400>  1
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gattggagga ggcgagatcc agccgggggg gtccctgaga      120

ctctcgtgtg cagcctctgg gttcaacgtc agtaagaact acatgagttg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gtaatctata gtggtggtgg tacagaatac      240

gcagcctccg tgaagggccg atttaacatc tccagagaca gttccaagaa tatgttgtat      300

cttcaaatga acaacctgag agccgaggac acggccgtgt attattgtgc gagggccgtc      360

cccaggcccc atgggactga tatctggggc caagggacaa tggtcaccgt ctcttcagag      420

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      480

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      540

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      600

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      660

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      720

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc      780

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag      840

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac      900

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      960

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1020

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1080

acgcagaaga gcctctccct gtctccgggt aaa                                  1113


<210>  2
<211>  371
<212>  PRT
<213>  Homo Sapiens

<400>  2

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Ile Gly Gly Gly Glu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Val Ser Lys Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Gly Thr Glu Tyr 
65                  70                  75                  80  


Ala Ala Ser Val Lys Gly Arg Phe Asn Ile Ser Arg Asp Ser Ser Lys 
                85                  90                  95      


Asn Met Leu Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro Arg Pro His Gly Thr Asp Ile 
        115                 120                 125             


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys 
    130                 135                 140                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
145                 150                 155                 160 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                165                 170                 175     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            180                 185                 190         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        195                 200                 205             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    210                 215                 220                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                245                 250                 255     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            260                 265                 270         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        275                 280                 285             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    290                 295                 300                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                325                 330                 335     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            340                 345                 350         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        355                 360                 365             


Pro Gly Lys 
    370     


<210>  3
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  3

Glu Val Gln Leu Val Glu Ile Gly Gly Gly Glu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Val Ser Lys Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Gly Thr Glu Tyr Ala Ala Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Asn Ile Ser Arg Asp Ser Ser Lys Asn Met Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro Arg Pro His Gly Thr Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  4
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  4

Gly Phe Asn Val Ser Lys Asn Tyr Met Ser 
1               5                   10  


<210>  5
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  5

Val Ile Tyr Ser Gly Gly Gly Thr Glu Tyr Ala Ala Ser Val Lys Gly 
1               5                   10                  15      


<210>  6
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  6

Ala Val Pro Arg Pro His Gly Thr Asp Ile 
1               5                   10  


<210>  7
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  7
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggcgga gactggagga ggcttgatcc agcctggggg gtccctgaga      120

ctctcctgtg cagtctctgg gttcaatgtc agtaagaatt acatgagctg ggtccgccag      180

gttccaggga aggggctgga gtgggtcgca gttgtttata gcggtggtag caaaacctac      240

gcagactccg tgaagggccg attcatcctc tccagagaca attccgacaa cacactgtat      300

cttcaaatga acaacctgag agccgaggac acggccgtgt attactgtgc gagagccgtt      360

cctcattccc ccagttcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  8
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  8

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Ala Glu Thr Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe 
        35                  40                  45              


Asn Val Ser Lys Asn Tyr Met Ser Trp Val Arg Gln Val Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Ile Leu Ser Arg Asp Asn Ser Asp 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  9
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  9

Glu Val Gln Leu Ala Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asn Val Ser Lys Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Leu Ser Arg Asp Asn Ser Asp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  10
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  10

Gly Phe Asn Val Ser Lys Asn Tyr Met Ser 
1               5                   10  


<210>  11
<211>  16
<212>  PRT
<213>  Homo Sapiens)

<400>  11

Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  12
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  12

Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  13
<211>  1116
<212>  DNA
<213>  Homo Sapiens)

<400>  13
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggagga gactggagga gacttgatcc agccgggggg gtccctgaga      120

ctctcctgta cagcctctgg gtttaacgtc agtagaatct acatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gtgatttata gcggtggaag tatatattac      240

gcagattccg tgaggggccg atttaccatc tccagagaca gttccacgaa cacggtgttt      300

cttcaaatga acagcctgag agccgaggac tcggccgtgt attactgtgc gagagccgtc      360

ccaagtgccc ctagttcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  14
<211>  372
<212>  PRT
<213>  Homo Sapiens)

<400>  14

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Glu Glu Thr Gly Gly Asp Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Asn Val Ser Arg Ile Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Thr 
                85                  90                  95      


Asn Thr Val Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro Ser Ala Pro Ser Ser Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  15
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  15

Glu Val Gln Leu Glu Glu Thr Gly Gly Asp Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Asn Val Ser Arg Ile 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Thr Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro Ser Ala Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  16
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  16

Gly Phe Asn Val Ser Arg Ile Tyr Met Ser 
1               5                   10  


<210>  17
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  17

Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Arg Gly 
1               5                   10                  15      


<210>  18
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  18

Ala Val Pro Ser Ala Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  19
<211>  1119
<212>  DNA
<213>  Homo Sapiens

<400>  19
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gtccggggga ggcttagttc agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg attcaccttc agtaactact ggatgcactg ggtccgccaa      180

gctccaggga aggggctggt gtgggtctca cgtattaata gtgatgggag taacacaacc      240

tacgcggact ccgtgaaggg ccgattcacc atctccagag acaacgccaa gaacacgctg      300

tatctgcaaa tgaacagtct gagagccgag gacacggctg tgtattactg tgcaagatgg      360

ttcggggagc actactacgg aatggacgtc tggggccaag ggaccacggt caccgtctct      420

tcagagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc      480

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      540

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      600

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      660

cagtacaaca gcacgtaccg ggtggtcagc gtcctcaccg tcctgcacca ggactggctg      720

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa      780

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc      840

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc      900

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg      960

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1020

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1080

cactacacgc agaagagcct ctccctgtct ccgggtaaa                            1119


<210>  20
<211>  373
<212>  PRT
<213>  Homo Sapiens

<400>  20

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Val Trp Val Ser Arg Ile Asn Ser Asp Gly Ser Asn Thr Thr 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Trp Phe Gly Glu His Tyr Tyr Gly Met 
        115                 120                 125             


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu Pro Lys 
    130                 135                 140                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                165                 170                 175     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            180                 185                 190         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        195                 200                 205             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    210                 215                 220                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
225                 230                 235                 240 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                245                 250                 255     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            260                 265                 270         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        275                 280                 285             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    290                 295                 300                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
305                 310                 315                 320 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                325                 330                 335     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            340                 345                 350         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        355                 360                 365             


Leu Ser Pro Gly Lys 
    370             


<210>  21
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Asn Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Phe Gly Glu His Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  22
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  22

Gly Phe Thr Phe Ser Asn Tyr Trp Met His 
1               5                   10  


<210>  23
<211>  17
<212>  PRT
<213>  Homo Sapiens

<400>  23

Arg Ile Asn Ser Asp Gly Ser Asn Thr Thr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  24

Trp Phe Gly Glu His Tyr Tyr Gly Met Asp Val 
1               5                   10      


<210>  25
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  25
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gactggagga gggctgatcc agccgggggg gtccctgaga      120

ctctcctgtg cagtctctgg gttcaccgtc agaaacaact acatgagctg ggcccgccag      180

gttccaggga agggactgga gtgggtctca gttatttata gcggtgggag tataacctac      240

gcagactccg tgaagggccg attcatcatc tccagagaca attccaacaa cacgctatat      300

cttcaaatga acggtctgag agccgaggac acggccgtat attactgtgc gagagccgtc      360

ccacatgccc caagtgcttt tgacatctgg ggccagggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  26
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  26

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe 
        35                  40                  45              


Thr Val Arg Asn Asn Tyr Met Ser Trp Ala Arg Gln Val Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Ile Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Asn 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ala Pro Ser Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  27
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  27

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Arg Asn Asn 
            20                  25                  30          


Tyr Met Ser Trp Ala Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ile Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Asn Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ala Pro Ser Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  28
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  28

Gly Phe Thr Val Arg Asn Asn Tyr Met Ser 
1               5                   10  


<210>  29
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  29

Val Ile Tyr Ser Gly Gly Ser Ile Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  30
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  30

Ala Val Pro His Ala Pro Ser Ala Phe Asp Ile 
1               5                   10      


<210>  31
<211>  1113
<212>  DNA
<213>  Homo Sapiens

<400>  31
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gactggagga ggcttaatcc agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg gctcaatgtc agtaggcact acttaagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtcgca gtaatttata gcggtggtgg tatagagtac      240

gtagactccg tgaagggccg attcaccatc tccagagaca atgccaacaa cacgctgtat      300

cttcaaatga gaagcctgag aaccgaagac tcggccgtat attactgtgc gcgggccatt      360

cccagacccc atggttcgga tatctggggc caagggacaa tggtcaccgt ctcttcagag      420

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      480

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      540

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      600

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      660

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      720

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc      780

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag      840

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac      900

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      960

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1020

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1080

acgcagaaga gcctctccct gtctccgggt aaa                                  1113


<210>  32
<211>  371
<212>  PRT
<213>  Homo Sapiens

<400>  32

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu 
        35                  40                  45              


Asn Val Ser Arg His Tyr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Val Ile Tyr Ser Gly Gly Gly Ile Glu Tyr 
65                  70                  75                  80  


Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Arg Ser Leu Arg Thr Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Ile Pro Arg Pro His Gly Ser Asp Ile 
        115                 120                 125             


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys 
    130                 135                 140                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
145                 150                 155                 160 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                165                 170                 175     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            180                 185                 190         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        195                 200                 205             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    210                 215                 220                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                245                 250                 255     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            260                 265                 270         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        275                 280                 285             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    290                 295                 300                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                325                 330                 335     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            340                 345                 350         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        355                 360                 365             


Pro Gly Lys 
    370     


<210>  33
<211>  118
<212>  PRT
<213>  Homo Sapiens

<400>  33

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Asn Val Ser Arg His 
            20                  25                  30          


Tyr Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Tyr Ser Gly Gly Gly Ile Glu Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Arg Ser Leu Arg Thr Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Ile Pro Arg Pro His Gly Ser Asp Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  34
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  34

Gly Leu Asn Val Ser Arg His Tyr Leu Ser 
1               5                   10  


<210>  35
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  35

Val Ile Tyr Ser Gly Gly Gly Ile Glu Tyr Val Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  36
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  36

Ala Ile Pro Arg Pro His Gly Ser Asp Ile 
1               5                   10  


<210>  37
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  37
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gactggagga ggcttgatcc agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg gttcaccgtc agtagcaact acatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gttatttata gcggtggtag cacatactac      240

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      300

cttcaaatga gcaacctgac cgccgaggac acggccgtgt attactgtgc gagagccgtt      360

ccccactccc ccagtgcttt tgataggtgg ggccagggaa ccctggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  38
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  38

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Val Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Ser Asn Leu Thr Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ser Pro Ser Ala Phe Asp 
        115                 120                 125             


Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  39
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  39

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Asn Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ser Pro Ser Ala Phe Asp Arg Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  40
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  40

Gly Phe Thr Val Ser Ser Asn Tyr Met Ser 
1               5                   10  


<210>  41
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  41

Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  42
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  42

Ala Val Pro His Ser Pro Ser Ala Phe Asp Arg 
1               5                   10      


<210>  43
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  43
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggagga gactggagga gacttgatcc agccgggggg gtccctgaga      120

ctctcctgta cagcctctgg gtttaacgtc agtagaatct acatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gtgatttata gcggtggaag tatatattac      240

gcagattccg tgaggggccg atttaccatc tccagagaca gttccacgaa cacggtgtat      300

cttcaaatga acagcctgag agccgaggac tcggccgtgt attactgtgc gagagccgtc      360

ccacatgccc ctagtaattt tgataaatgg ggccaaggga caagggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  44
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  44

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Glu Glu Thr Gly Gly Asp Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Asn Val Ser Arg Ile Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Thr 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ala Pro Ser Asn Phe Asp 
        115                 120                 125             


Lys Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  45
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  45

Glu Val Gln Leu Glu Glu Thr Gly Gly Asp Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Asn Val Ser Arg Ile 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Thr Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ala Pro Ser Asn Phe Asp Lys Trp Gly Gln Gly 
            100                 105                 110         


Thr Arg Val Thr Val Ser Ser 
        115                 


<210>  46
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  46

Gly Phe Asn Val Ser Arg Ile Tyr Met Ser 
1               5                   10  


<210>  47
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  47

Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Arg Gly 
1               5                   10                  15      


<210>  48
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  48

Ala Val Pro His Ala Pro Ser Asn Phe Asp Lys 
1               5                   10      


<210>  49
<211>  1125
<212>  DNA
<213>  Homo Sapiens

<400>  49
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gtctggggga ggcttggttc agccgggggg gtccctgcga      120

ctctcctgtg tagcctctgg attcaccttc agtaactatt ggatgcactg ggtccgccaa      180

attccaggga aggggatggt gtggatctca gaaattaaca gtgacgggaa taggacaggc      240

tatgcggact ccgtaaaggg ccgattcacc atctccagag acaacgccaa gaagatgttg      300

tatctgcaaa tgaacagtct gagagccgag gacacggctg tttattattg tgcaagaaac      360

tggggatcgg gcccccatca taccgctttt gatggttggg gccaagggac aatggtcacc      420

gtctcttcag agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      480

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      540

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      600

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      660

gaggagcagt acaacagcac gtaccgggtg gtcagcgtcc tcaccgtcct gcaccaggac      720

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      780

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc      840

ccatcccggg aggagatgac caagaaccag gtcagcctga cctgcctggt caaaggcttc      900

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag      960

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1020

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1080

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1125


<210>  50
<211>  375
<212>  PRT
<213>  Homo Sapiens

<400>  50

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Asn Tyr Trp Met His Trp Val Arg Gln Ile Pro Gly Lys 
    50                  55                  60                  


Gly Met Val Trp Ile Ser Glu Ile Asn Ser Asp Gly Asn Arg Thr Gly 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Lys Met Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Arg Asn Trp Gly Ser Gly Pro His His Thr 
        115                 120                 125             


Ala Phe Asp Gly Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu 
    130                 135                 140                 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
145                 150                 155                 160 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                165                 170                 175     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            180                 185                 190         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        195                 200                 205             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    210                 215                 220                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
225                 230                 235                 240 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                245                 250                 255     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            260                 265                 270         


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
        275                 280                 285             


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
    290                 295                 300                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
305                 310                 315                 320 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
                325                 330                 335     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            340                 345                 350         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        355                 360                 365             


Leu Ser Leu Ser Pro Gly Lys 
    370                 375 


<210>  51
<211>  122
<212>  PRT
<213>  Homo Sapiens

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ile Pro Gly Lys Gly Met Val Trp Ile 
        35                  40                  45              


Ser Glu Ile Asn Ser Asp Gly Asn Arg Thr Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Trp Gly Ser Gly Pro His His Thr Ala Phe Asp Gly Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  52
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  52

Gly Phe Thr Phe Ser Asn Tyr Trp Met His 
1               5                   10  


<210>  53
<211>  17
<212>  PRT
<213>  Homo Sapiens

<400>  53

Glu Ile Asn Ser Asp Gly Asn Arg Thr Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  54
<211>  13
<212>  PRT
<213>  Homo Sapiens

<400>  54

Asn Trp Gly Ser Gly Pro His His Thr Ala Phe Asp Gly 
1               5                   10              


<210>  55
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  55
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggagga gactggagga gacttgatcc agccgggggg gtccctgaga      120

ctctcctgta cagcctctgg gtttaccgtc agtagaatct acatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gtgatttata gcggtggaag tatatattac      240

gcagattccg tgaggggccg atttaccatc tccagagaca gttccacgaa cacggtgttt      300

cttcaaatga acagcctgag agccgaggac tcggccgtgt attactgtgc gagagccgtc      360

ccaagtgccc ctagttcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  56
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  56

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Glu Glu Thr Gly Gly Asp Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Thr Val Ser Arg Ile Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Thr 
                85                  90                  95      


Asn Thr Val Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro Ser Ala Pro Ser Ser Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  57
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  57

Glu Val Gln Leu Glu Glu Thr Gly Gly Asp Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Val Ser Arg Ile 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Thr Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro Ser Ala Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  58
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  58

Gly Phe Thr Val Ser Arg Ile Tyr Met Ser 
1               5                   10  


<210>  59
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  59

Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Arg Gly 
1               5                   10                  15      


<210>  60
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  60

Ala Val Pro Ser Ala Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  61
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  61
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gagcggagga ggcttgatcc agccgggggg gtccctgaga      120

ctctcctgtg ccgcctctgg gtttaccgtc agtagaatct acatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gtgatttata gcggtggaag tatatattac      240

gcagattccg tgaagggccg atttaccatc tccagagaca gttccaagaa cacggtgtac      300

cttcaaatga acagcctgag agccgaggac accgccgtgt attactgtgc gagagccgtc      360

ccaagtgccc ctagttcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  62
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  62

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Val Ser Arg Ile Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro Ser Ala Pro Ser Ser Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  63
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  63

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Arg Ile 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro Ser Ala Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  64
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  64

Gly Phe Thr Val Ser Arg Ile Tyr Met Ser 
1               5                   10  


<210>  65
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  65

Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  66
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  66

Ala Val Pro Ser Ala Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  67
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  67
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gactggagga gggctgatcc agccgggggg gtccctgaga      120

ctctcctgtg cagtctctgg gttcaccgtc agaaacaact acatgagctg ggcccgccag      180

gttccaggga agggactgga gtgggtctca gttatttata gcggtgggag tataacctac      240

gcagactccg tgaagggccg attcatcatc tccagagaca attccaagaa cacgctatat      300

cttcaaatga acggtctgag agccgaggac acggccgtat attactgtgc gagagccgtc      360

ccacatgccc caagtgcttt tgacatctgg ggccagggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  68
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  68

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe 
        35                  40                  45              


Thr Val Arg Asn Asn Tyr Met Ser Trp Ala Arg Gln Val Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Ile Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ala Pro Ser Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  69
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  69

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Arg Asn Asn 
            20                  25                  30          


Tyr Met Ser Trp Ala Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ile Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ala Pro Ser Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  70
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  70

Gly Phe Thr Val Arg Asn Asn Tyr Met Ser 
1               5                   10  


<210>  71
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  71

Val Ile Tyr Ser Gly Gly Ser Ile Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  72
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  72

Ala Val Pro His Ala Pro Ser Ala Phe Asp Ile 
1               5                   10      


<210>  73
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  73
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gagcggagga gggctgatcc agccgggggg gtccctgaga      120

ctctcctgtg cagcctctgg gttcaccgtc agaaacaact acatgagctg ggtgcgccag      180

gccccaggga agggactgga gtgggtctca gttatttata gcggtgggag tataacctac      240

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctatat      300

cttcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gagagccgtc      360

ccacatgccc caagtgcttt tgacatctgg ggccagggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  74
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  74

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Val Arg Asn Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Ile Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ala Pro Ser Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  75
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  75

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Arg Asn Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ile Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ala Pro Ser Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  76
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  76

Gly Phe Thr Val Arg Asn Asn Tyr Met Ser 
1               5                   10  


<210>  77
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  77

Val Ile Tyr Ser Gly Gly Ser Ile Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  78
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  78

Ala Val Pro His Ala Pro Ser Ala Phe Asp Ile 
1               5                   10      


<210>  79
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  79
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gactggagga ggcttgatcc agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg gttcaccgtc agtagcaact acatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gttatttata gcggtggtag cacatactac      240

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      300

cttcaaatga gcagcctgag ggccgaggac acggccgtgt attactgtgc gagagccgtt      360

ccccactccc ccagtgcttt tgataggtgg ggccagggaa ccctggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  80
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  80

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Val Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ser Pro Ser Ala Phe Asp 
        115                 120                 125             


Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  81
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  81

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ser Pro Ser Ala Phe Asp Arg Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  82
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  82

Gly Phe Thr Val Ser Ser Asn Tyr Met Ser 
1               5                   10  


<210>  83
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  83

Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  84
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  84

Ala Val Pro His Ser Pro Ser Ala Phe Asp Arg 
1               5                   10      


<210>  85
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  85
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gagcggagga ggcttgatcc agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg gttcaccgtc agtagcaact acatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gttatttata gcggtggtag cacatactac      240

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      300

cttcaaatga acagcctgag ggccgaggac acggccgtgt attactgtgc gagagccgtt      360

ccccactccc ccagtgcttt tgataggtgg ggccagggaa ccctggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  86
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  86

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Val Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ser Pro Ser Ala Phe Asp 
        115                 120                 125             


Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  87
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ser Pro Ser Ala Phe Asp Arg Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  88
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  88

Gly Phe Thr Val Ser Ser Asn Tyr Met Ser 
1               5                   10  


<210>  89
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  89

Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  90
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  90

Ala Val Pro His Ser Pro Ser Ala Phe Asp Arg 
1               5                   10      


<210>  91
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  91
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggagga gactggagga gacttgatcc agccgggggg gtccctgaga      120

ctctcctgta cagcctctgg gtttaccgtc agtagaatct acatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gtgatttata gcggtggaag tatatattac      240

gcagattccg tgaggggccg atttaccatc tccagagaca gttccacgaa cacggtgtat      300

cttcaaatga acagcctgag agccgaggac tcggccgtgt attactgtgc gagagccgtc      360

ccacatgccc ctagtaattt tgataaatgg ggccaaggga caagggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  92
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  92

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Glu Glu Thr Gly Gly Asp Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Thr Val Ser Arg Ile Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Thr 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ala Pro Ser Asn Phe Asp 
        115                 120                 125             


Lys Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  93
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  93

Glu Val Gln Leu Glu Glu Thr Gly Gly Asp Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Val Ser Arg Ile 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Thr Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ala Pro Ser Asn Phe Asp Lys Trp Gly Gln Gly 
            100                 105                 110         


Thr Arg Val Thr Val Ser Ser 
        115                 


<210>  94
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  94

Gly Phe Thr Val Ser Arg Ile Tyr Met Ser 
1               5                   10  


<210>  95
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  95

Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Arg Gly 
1               5                   10                  15      


<210>  96
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  96

Ala Val Pro His Ala Pro Ser Asn Phe Asp Lys 
1               5                   10      


<210>  97
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  97
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggcgga gactggagga ggcttgatcc agcctggggg gtccctgaga      120

ctctcctgtg cagtctctgg gttcaccgtc agtaagaatt acatgagctg ggtccgccag      180

gttccaggga aggggctgga gtgggtcgca gttgtttata gcggtggtag caaaacctac      240

gcagactccg tgaagggccg attcatcctc tccagagaca attccgacaa cacactgtat      300

cttcaaatga acaacctgag agccgaggac acggccgtgt attactgtgc gagagccgtt      360

cctcattccc ccagttcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  98
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  98

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Val Ser Arg Ile Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ala Pro Ser Asn Phe Asp 
        115                 120                 125             


Lys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  99
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  99

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Arg Ile 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ala Pro Ser Asn Phe Asp Lys Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  100
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  100

Gly Phe Thr Val Ser Arg Ile Tyr Met Ser 
1               5                   10  


<210>  101
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  101

Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  102
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  102

Ala Val Pro His Ala Pro Ser Asn Phe Asp Lys 
1               5                   10      


<210>  103
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  103
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggcgga gactggagga ggcttgatcc agcctggggg gtccctgaga      120

ctctcctgtg cagtctctgg gttcaccgtc agtaagaatt acatgagctg ggtccgccag      180

gttccaggga aggggctgga gtgggtcgca gttgtttata gcggtggtag caaaacctac      240

gcagactccg tgaagggccg attcatcctc tccagagaca attccgacaa cacactgtat      300

cttcaaatga acaacctgag agccgaggac acggccgtgt attactgtgc gagagccgtt      360

cctcattccc ccagttcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  104
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  104

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Ala Glu Thr Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe 
        35                  40                  45              


Thr Val Ser Lys Asn Tyr Met Ser Trp Val Arg Gln Val Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Ile Leu Ser Arg Asp Asn Ser Asp 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  105
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  105

Glu Val Gln Leu Ala Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Ser Lys Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Leu Ser Arg Asp Asn Ser Asp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  106
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  106

Gly Phe Thr Val Ser Lys Asn Tyr Met Ser 
1               5                   10  


<210>  107
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  107

Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  108
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  108

Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  109
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  109
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gagcggagga ggcttgatcc agcctggggg gtccctgaga      120

ctctcctgtg cagtctctgg gttcaccgtc agtaagaatt acatgagctg ggtccgccag      180

gccccaggga aggggctgga gtgggtcagc gttgtttata gcggtggtag caaaacctac      240

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacactgtat      300

cttcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagccgtt      360

cctcattccc ccagttcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  110
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  110

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe 
        35                  40                  45              


Thr Val Ser Lys Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  111
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  111

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Ser Lys Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  112
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  112

Gly Phe Thr Val Ser Lys Asn Tyr Met Ser 
1               5                   10  


<210>  113
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  113

Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  114
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  114

Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  115
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  115
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggagga gactggagga gacttgatcc agccgggggg gtccctgaga      120

ctctcctgta cagcctctgg gtttaacgtc agtagaatct acatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gtgatttata gcggtggaag tatatattac      240

gcagattccg tgaggggccg atttaccatc tccagagaca gttccacgaa cacggtgttt      300

cttcaaatga acagcctgag agccgaggac tcggccgtgt attactgtgc gagagccgtc      360

ccaagtgccc ctagttcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgg acgtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccga ggagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  116
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  116

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Glu Glu Thr Gly Gly Asp Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Asn Val Ser Arg Ile Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Thr 
                85                  90                  95      


Asn Thr Val Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro Ser Ala Pro Ser Ser Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  117
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  117

Glu Val Gln Leu Glu Glu Thr Gly Gly Asp Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Asn Val Ser Arg Ile 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Thr Asn Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro Ser Ala Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  118
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  118

Gly Phe Asn Val Ser Arg Ile Tyr Met Ser 
1               5                   10  


<210>  119
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  119

Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Arg Gly 
1               5                   10                  15      


<210>  120
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  120

Ala Val Pro Ser Ala Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  121
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  121
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gactggagga gggctgatcc agccgggggg gtccctgaga      120

ctctcctgtg cagtctctgg gttcaccgtc agaaacaact acatgagctg ggcccgccag      180

gttccaggga agggactgga gtgggtctca gttatttata gcggtgggag tataacctac      240

gcagactccg tgaagggccg attcatcatc tccagagaca attccaacaa cacgctatat      300

cttcaaatga acggtctgag agccgaggac acggccgtat attactgtgc gagagccgtc      360

ccacatgccc caagtgcttt tgacatctgg ggccagggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgg acgtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccga ggagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  122
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  122

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe 
        35                  40                  45              


Thr Val Arg Asn Asn Tyr Met Ser Trp Ala Arg Gln Val Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Ile Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Asn 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ala Pro Ser Ala Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  123
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  123

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Arg Asn Asn 
            20                  25                  30          


Tyr Met Ser Trp Ala Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ile Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Asn Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Gly Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ala Pro Ser Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  124
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  124

Gly Phe Thr Val Arg Asn Asn Tyr Met Ser 
1               5                   10  


<210>  125
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  125

Val Ile Tyr Ser Gly Gly Ser Ile Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  126
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  126

Ala Val Pro His Ala Pro Ser Ala Phe Asp Ile 
1               5                   10      


<210>  127
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  127
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gactggagga ggcttgatcc agcctggggg gtccctgaga      120

ctctcctgtg cagcctctgg gttcaccgtc agtagcaact acatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gttatttata gcggtggtag cacatactac      240

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      300

cttcaaatga gcaacctgac cgccgaggac acggccgtgt attactgtgc gagagccgtt      360

ccccactccc ccagtgcttt tgataggtgg ggccagggaa ccctggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgg acgtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccga ggagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  128
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  128

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Val Ser Ser Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Ser Asn Leu Thr Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ser Pro Ser Ala Phe Asp 
        115                 120                 125             


Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  129
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  129

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Asn Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ser Pro Ser Ala Phe Asp Arg Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  130
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  130

Gly Phe Thr Val Ser Ser Asn Tyr Met Ser 
1               5                   10  


<210>  131
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  131

Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  132
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  132

Ala Val Pro His Ser Pro Ser Ala Phe Asp Arg 
1               5                   10      


<210>  133
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  133
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggagga gactggagga gacttgatcc agccgggggg gtccctgaga      120

ctctcctgta cagcctctgg gtttaacgtc agtagaatct acatgagctg ggtccgccag      180

gctccaggga aggggctgga gtgggtctca gtgatttata gcggtggaag tatatattac      240

gcagattccg tgaggggccg atttaccatc tccagagaca gttccacgaa cacggtgtat      300

cttcaaatga acagcctgag agccgaggac tcggccgtgt attactgtgc gagagccgtc      360

ccacatgccc ctagtaattt tgataaatgg ggccaaggga caagggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgg acgtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccga ggagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  134
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  134

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Glu Glu Thr Gly Gly Asp Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe 
        35                  40                  45              


Asn Val Ser Arg Ile Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Thr 
                85                  90                  95      


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ala Pro Ser Asn Phe Asp 
        115                 120                 125             


Lys Trp Gly Gln Gly Thr Arg Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  135
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  135

Glu Val Gln Leu Glu Glu Thr Gly Gly Asp Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Asn Val Ser Arg Ile 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Thr Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ala Pro Ser Asn Phe Asp Lys Trp Gly Gln Gly 
            100                 105                 110         


Thr Arg Val Thr Val Ser Ser 
        115                 


<210>  136
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  136

Gly Phe Asn Val Ser Arg Ile Tyr Met Ser 
1               5                   10  


<210>  137
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  137

Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Arg Gly 
1               5                   10                  15      


<210>  138
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  138

Ala Val Pro His Ala Pro Ser Asn Phe Asp Lys 
1               5                   10      


<210>  139
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  139
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggcgga gactggagga ggcttgatcc agcctggggg gtccctgaga      120

ctctcctgtg cagtctctgg gttcaatgtc agtaagaatt acatgagctg ggtccgccag      180

gttccaggga aggggctgga gtgggtcgca gttgtttata gcggtggtag caaaacctac      240

gcagactccg tgaagggccg attcatcctc tccagagaca attccgacaa cacactgtat      300

cttcaaatga acaacctgag agccgaggac acggccgtgt attactgtgc gagagccgtt      360

cctcattccc ccagttcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgg acgtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccga ggagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  140
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  140

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Ala Glu Thr Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe 
        35                  40                  45              


Asn Val Ser Lys Asn Tyr Met Ser Trp Val Arg Gln Val Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Ile Leu Ser Arg Asp Asn Ser Asp 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  141
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  141

Glu Val Gln Leu Ala Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Asn Val Ser Lys Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Leu Ser Arg Asp Asn Ser Asp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  142
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  142

Gly Phe Asn Val Ser Lys Asn Tyr Met Ser 
1               5                   10  


<210>  143
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  143

Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  144
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  144

Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  145
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  145
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggcgga gactggagga ggcttgatcc agcctggggg gtccctgaga      120

ctctcctgtg cagtctctgg gttcaccgtc agtaagaatt acatgagctg ggtccgccag      180

gttccaggga aggggctgga gtgggtcgca gttgtttata gcggtggtag caaaacctac      240

gcagactccg tgaagggccg attcatcctc tccagagaca attccgacaa cacactgtat      300

cttcaaatga acaacctgag agccgaggac acggccgtgt attactgtgc gagagccgtt      360

cctcattccc ccagttcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgg acgtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccga ggagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  146
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  146

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Ala Glu Thr Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe 
        35                  40                  45              


Thr Val Ser Lys Asn Tyr Met Ser Trp Val Arg Gln Val Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Ile Leu Ser Arg Asp Asn Ser Asp 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  147
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  147

Glu Val Gln Leu Ala Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Ser Lys Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Ile Leu Ser Arg Asp Asn Ser Asp Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  148
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  148

Gly Phe Thr Val Ser Lys Asn Tyr Met Ser 
1               5                   10  


<210>  149
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  149

Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  150
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  150

Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  151
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  151
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

tctgaggtgc agctggtgga gagcggagga ggcttgatcc agcctggggg gtccctgaga      120

ctctcctgtg cagtctctgg gttcaccgtc agtaagaatt acatgagctg ggtccgccag      180

gccccaggga aggggctgga gtgggtcagc gttgtttata gcggtggtag caaaacctac      240

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacactgtat      300

cttcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagccgtt      360

cctcattccc ccagttcttt tgatatctgg ggccaaggga caatggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgg acgtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccga ggagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  152
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  152

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Ile Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe 
        35                  40                  45              


Thr Val Ser Lys Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ser Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp 
        115                 120                 125             


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  153
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  153

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Ser Lys Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  154
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  154

Gly Phe Thr Val Ser Lys Asn Tyr Met Ser 
1               5                   10  


<210>  155
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  155

Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  156
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  156

Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  157
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  157
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

gaggtgcagc tggtggagtc cgggggaggc ttagttcagc ctggggggtc cctgagactc      120

tcctgtgcag cctctggatt caccttcagt aactactgga tgcactgggt ccgccaagct      180

ccagggaagg ggctggtgtg ggtctcacgt attaatagtg atgggagtaa cacaacctac      240

gcggactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat      300

ctgcaaatga acagtctgag agccgaggac acggctgtgt attactgtgc aagatggttc      360

ggggagcact actacggaat ggacgtctgg ggccaaggga ccacggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  158
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  158

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asn Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Val Trp Val Ser Arg Ile Asn Ser Asp Gly Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Trp Phe Gly Glu His Tyr Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  159
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  159

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Asn Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Phe Gly Glu His Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  160
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  160

Gly Phe Thr Phe Ser Asn Tyr Trp Met His 
1               5                   10  


<210>  161
<211>  17
<212>  PRT
<213>  Homo Sapiens

<400>  161

Arg Ile Asn Ser Asp Gly Ser Asn Thr Thr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  162
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  162

Trp Phe Gly Glu His Tyr Tyr Gly Met Asp Val 
1               5                   10      


<210>  163
<211>  1113
<212>  DNA
<213>  Homo Sapiens

<400>  163
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

gaggtgcagc tggtggagag cggaggaggc ttgatccagc cgggggggtc cctgagactc      120

tcctgtgccg cctctgggtt taccgtcagt agaatctaca tgagctgggt ccgccaggct      180

ccagggaagg ggctggagtg ggtctcagtg atttatagcg gtggaagtat atattacgca      240

gattccgtga agggccgatt taccatctcc agagacagtt ccaagaacac ggtgtacctt      300

caaatgaaca gcctgagagc cgaggacacc gccgtgtatt actgtgcgag agccgtccca      360

agtgccccta gttcttttga tatctggggc caagggacaa tggtcaccgt ctcttcagag      420

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      480

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      540

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      600

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      660

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      720

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc      780

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag      840

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac      900

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      960

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1020

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1080

acgcagaaga gcctctccct gtctccgggt aaa                                  1113


<210>  164
<211>  371
<212>  PRT
<213>  Homo Sapiens

<400>  164

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Val Ser Arg Ile Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Val Pro Ser Ala Pro Ser Ser Phe Asp Ile 
        115                 120                 125             


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys 
    130                 135                 140                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
145                 150                 155                 160 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                165                 170                 175     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            180                 185                 190         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        195                 200                 205             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    210                 215                 220                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                245                 250                 255     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            260                 265                 270         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        275                 280                 285             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    290                 295                 300                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                325                 330                 335     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            340                 345                 350         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        355                 360                 365             


Pro Gly Lys 
    370     


<210>  165
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  165

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Arg Ile 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro Ser Ala Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  166
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  166

Gly Phe Thr Val Ser Arg Ile Tyr Met Ser 
1               5                   10  


<210>  167
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  167

Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  168
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  168

Ala Val Pro Ser Ala Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  169
<211>  1113
<212>  DNA
<213>  Homo Sapiens

<400>  169
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

gaggtgcagc tggtggagag cggaggaggc ttgatccagc ctggggggtc cctgagactc      120

tcctgtgcag tctctgggtt caccgtcagt aagaattaca tgagctgggt ccgccaggcc      180

ccagggaagg ggctggagtg ggtcagcgtt gtttatagcg gtggtagcaa aacctacgca      240

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac actgtatctt      300

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agccgttcct      360

cattccccca gttcttttga tatctggggc caagggacaa tggtcaccgt ctcttcagag      420

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      480

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      540

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      600

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      660

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      720

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc      780

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag      840

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac      900

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      960

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1020

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1080

acgcagaaga gcctctccct gtctccgggt aaa                                  1113


<210>  170
<211>  371
<212>  PRT
<213>  Homo Sapiens

<400>  170

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr 
        35                  40                  45              


Val Ser Lys Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile 
        115                 120                 125             


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys 
    130                 135                 140                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
145                 150                 155                 160 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                165                 170                 175     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            180                 185                 190         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        195                 200                 205             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    210                 215                 220                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                245                 250                 255     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            260                 265                 270         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        275                 280                 285             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    290                 295                 300                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                325                 330                 335     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            340                 345                 350         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        355                 360                 365             


Pro Gly Lys 
    370     


<210>  171
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  171

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Ser Lys Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  172
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  172

Gly Phe Thr Val Ser Lys Asn Tyr Met Ser 
1               5                   10  


<210>  173
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  173

Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  174
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  174

Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  175
<211>  1113
<212>  DNA
<213>  Homo Sapiens

<400>  175
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

gaggtgcagc tggtggagag cggaggaggc ttgatccagc cgggggggtc cctgagactc      120

tcctgtgccg cctctgggtt taccgtcagt agaatctaca tgagctgggt ccgccaggct      180

ccagggaagg ggctggagtg ggtctcagtg atttatagcg gtggaagtat atattacgca      240

gattccgtga agggccgatt taccatctcc agagacagtt ccaagaacac ggtgtacctt      300

caaatgaaca gcctgagagc cgaggacacc gccgtgtatt actgtgcgag agccgtccca      360

agtgccccta gttcttttga tatctggggc caagggacaa tggtcaccgt ctcttcagag      420

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      480

ggaccggacg tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      540

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      600

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      660

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      720

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccgagga gaaaaccatc      780

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag      840

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac      900

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      960

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1020

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1080

acgcagaaga gcctctccct gtctccgggt aaa                                  1113


<210>  176
<211>  371
<212>  PRT
<213>  Homo Sapiens

<400>  176

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Val Ser Arg Ile Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn 
                85                  90                  95      


Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Val Pro Ser Ala Pro Ser Ser Phe Asp Ile 
        115                 120                 125             


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys 
    130                 135                 140                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
145                 150                 155                 160 


Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                165                 170                 175     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            180                 185                 190         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        195                 200                 205             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    210                 215                 220                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Glu 
                245                 250                 255     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            260                 265                 270         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        275                 280                 285             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    290                 295                 300                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                325                 330                 335     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            340                 345                 350         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        355                 360                 365             


Pro Gly Lys 
    370     


<210>  177
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  177

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Arg Ile 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro Ser Ala Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  178
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  178

Gly Phe Thr Val Ser Arg Ile Tyr Met Ser 
1               5                   10  


<210>  179
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  179

Val Ile Tyr Ser Gly Gly Ser Ile Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  180
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  180

Ala Val Pro Ser Ala Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  181
<211>  1113
<212>  DNA
<213>  Homo Sapiens

<400>  181
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

gaggtgcagc tggtggagag cggaggaggc ttgatccagc ctggggggtc cctgagactc      120

tcctgtgcag tctctgggtt caccgtcagt aagaattaca tgagctgggt ccgccaggcc      180

ccagggaagg ggctggagtg ggtcagcgtt gtttatagcg gtggtagcaa aacctacgca      240

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac actgtatctt      300

caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag agccgttcct      360

cattccccca gttcttttga tatctggggc caagggacaa tggtcaccgt ctcttcagag      420

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg      480

ggaccggacg tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      540

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      600

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      660

aacagcacgt accgggtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc      720

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccgagga gaaaaccatc      780

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag      840

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac      900

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc      960

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1020

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1080

acgcagaaga gcctctccct gtctccgggt aaa                                  1113


<210>  182
<211>  371
<212>  PRT
<213>  Homo Sapiens

<400>  182

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr 
        35                  40                  45              


Val Ser Lys Asn Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile 
        115                 120                 125             


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Glu Pro Lys Ser Cys 
    130                 135                 140                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
145                 150                 155                 160 


Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                165                 170                 175     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            180                 185                 190         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        195                 200                 205             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    210                 215                 220                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
225                 230                 235                 240 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Glu 
                245                 250                 255     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            260                 265                 270         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        275                 280                 285             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    290                 295                 300                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
305                 310                 315                 320 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                325                 330                 335     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            340                 345                 350         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        355                 360                 365             


Pro Gly Lys 
    370     


<210>  183
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  183

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Val Ser Lys Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  184
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  184

Gly Phe Thr Val Ser Lys Asn Tyr Met Ser 
1               5                   10  


<210>  185
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  185

Val Val Tyr Ser Gly Gly Ser Lys Thr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  186
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  186

Ala Val Pro His Ser Pro Ser Ser Phe Asp Ile 
1               5                   10      


<210>  187
<211>  1116
<212>  DNA
<213>  Homo Sapiens

<400>  187
atggagaccg acaccctgct gctgtgggtg ctgctgctgt gggtgcccgg atccaccggc       60

gaggtgcagc tggtggagtc cgggggaggc ttagttcagc ctggggggtc cctgagactc      120

tcctgtgcag cctctggatt caccttcagt aactactgga tgcactgggt ccgccaagct      180

ccagggaagg ggctggtgtg ggtctcacgt attaatagtg atgggagtaa cacaacctac      240

gcggactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgctgtat      300

ctgcaaatga acagtctgag agccgaggac acggctgtgt attactgtgc aagatggttc      360

ggggagcact actacggaat ggacgtctgg ggccaaggga ccacggtcac cgtctcttca      420

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg      480

gggggaccgg acgtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      540

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      600

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      660

tacaacagca cgtaccgggt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat      720

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccga ggagaaaacc      780

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg      840

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc      900

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct      960

cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1020

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1080

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1116


<210>  188
<211>  372
<212>  PRT
<213>  Homo Sapiens

<400>  188

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Ser Asn Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Val Trp Val Ser Arg Ile Asn Ser Asp Gly Ser Asn Thr Thr Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Arg Trp Phe Gly Glu His Tyr Tyr Gly Met Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Glu Pro Lys Ser 
    130                 135                 140                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
145                 150                 155                 160 


Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                165                 170                 175     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            180                 185                 190         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        195                 200                 205             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    210                 215                 220                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
225                 230                 235                 240 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                245                 250                 255     


Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            260                 265                 270         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        275                 280                 285             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    290                 295                 300                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
305                 310                 315                 320 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                325                 330                 335     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            340                 345                 350         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        355                 360                 365             


Ser Pro Gly Lys 
    370         


<210>  189
<211>  120
<212>  PRT
<213>  Homo Sapiens

<400>  189

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Asn Thr Thr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp Phe Gly Glu His Tyr Tyr Gly Met Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  190
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  190

Gly Phe Thr Phe Ser Asn Tyr Trp Met His 
1               5                   10  


<210>  191
<211>  17
<212>  PRT
<213>  Homo Sapiens

<400>  191

Arg Ile Asn Ser Asp Gly Ser Asn Thr Thr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  192
<211>  11
<212>  PRT
<213>  Homo Sapiens

<400>  192

Trp Phe Gly Glu His Tyr Tyr Gly Met Asp Val 
1               5                   10      


<210>  193
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  193
gtgtccagtg tgaggtgcag ctg                                               23


<210>  194
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  194
gtgtccagtg tcaggtgcag ctg                                               23


<210>  195
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Primer

<400>  195
ggcttacaac cacaatccct gggc                                              24


<210>  196
<211>  672
<212>  DNA
<213>  Homo Sapiens

<400>  196
atggcttgcc ttggatttca gcggcacaag gctcagctga acctggctac caggacctgg       60

ccctgcactc tcctgttttt tcttctcttc atccctgtct tctgcaaagc aatgcacgtg      120

gcccagcctg ctgtggtact ggccagcagc cgaggcatcg ccagctttgt gtgtgagtat      180

gcatctccag gcaaagccac tgaggtccgg gtgacagtgc ttcggcaggc tgacagccag      240

gtgactgaag tctgtgcggc aacctacatg atggggaatg agttgacctt cctagatgat      300

tccatctgca cgggcacctc cagtggaaat caagtgaacc tcactatcca aggactgagg      360

gccatggaca cgggactcta catctgcaag gtggagctca tgtacccacc gccatactac      420

ctgggcatag gcaacggaac ccagatttat gtaattgatc cagaaccgtg cccagattct      480

gacttcctcc tctggatcct tgcagcagtt agttcggggt tgttttttta tagctttctc      540

ctcacagctg tttctttgag caaaatgcta aagaaaagaa gccctcttac aacaggggtc      600

tatgtgaaaa tgcccccaac agagccagaa tgtgaaaagc aatttcagcc ttattttatt      660

cccatcaatt ga                                                          672


<210>  197
<211>  223
<212>  PRT
<213>  Homo Sapiens

<400>  197

Met Ala Cys Leu Gly Phe Gln Arg His Lys Ala Gln Leu Asn Leu Ala 
1               5                   10                  15      


Thr Arg Thr Trp Pro Cys Thr Leu Leu Phe Phe Leu Leu Phe Ile Pro 
            20                  25                  30          


Val Phe Cys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala 
        35                  40                  45              


Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly 
    50                  55                  60                  


Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln 
65                  70                  75                  80  


Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr 
                85                  90                  95      


Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val 
            100                 105                 110         


Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile 
        115                 120                 125             


Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly 
    130                 135                 140                 


Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser 
145                 150                 155                 160 


Asp Phe Leu Leu Trp Ile Leu Ala Ala Val Ser Ser Gly Leu Phe Phe 
                165                 170                 175     


Tyr Ser Phe Leu Leu Thr Ala Val Ser Leu Ser Lys Met Leu Lys Lys 
            180                 185                 190         


Arg Ser Pro Leu Thr Thr Gly Val Tyr Val Lys Met Pro Pro Thr Glu 
        195                 200                 205             


Pro Glu Cys Glu Lys Gln Phe Gln Pro Tyr Phe Ile Pro Ile Asn 
    210                 215                 220             


<210>  198
<211>  672
<212>  DNA
<213>  Macaca mulatta

<400>  198
atggcttgcc ttggatttca gcggcacaag gctcggctca acctggctac caggacccgg       60

ccctacactc tcctgttttc tcttctcttc atccctgtct tctccaaagc aatgcacgtg      120

gcccagcctg ctgtggtgct ggccaacagc cgagggatcg ccagctttgt gtgtgagtat      180

gcatctccag gcaaagccac tgaggtccgg gtgacagtgc ttcggcaggc cgacagccag      240

gtgactgaag tctgtgcggc aacatacatg atggggaatg agttgacctt cctagatgat      300

tccatctgca cgggcacctc cagtggaaat caagtgaacc tcactatcca aggactgagg      360

gctatggaca caggactcta catctgcaag gtggagctca tgtacccacc accatactac      420

atgggcatag gcaatggaac ccagatttat gtaattgatc cagaaccgtg cccagattct      480

gacttcctcc tctggatcct tgcagcagtt agttcggggt tgttttttta tagctttctc      540

ctcacagctg tttctttgag caaaatgcta aagaaaagaa gccctctcac aacaggggtc      600

tatgtgaaaa tgcccccaac agagccagaa tgtgaaaagc aatttcagcc ttattttatt      660

cccatcaatt ga                                                          672


<210>  199
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  heavy chain of Ipilimumab analogue

<400>  199

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  200
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  light chain of Ipilimumab analogue

<400>  200

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 

