                               SEQUENCE LISTING

<110> APELLIS PHARMACEUTICALS, INC. 
 
<120> DOSING REGIMENS AND RELATED COMPOSITIONS AND METHODS 

<130> 2008575-0326

<140> PCT/US2018/065870 
<141> 2018-12-14

<150> 62/744,565
<151> 2018-10-11

<150> 62/655,094
<151> 2018-04-09

<150> 62/599,637
<151> 2017-12-15

<160> 74    

<170> PatentIn version 3.5

<210> 1
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond

<400> 1
Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210> 2
<211> 42
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(19)
<223> Any independently selected amino acid or amino
      acid analog

<220>
<221> misc_feature
<222> (1)..(19)
<223> This region may encompass 2 to 19 residues, wherein
      some residues may be absent

<220>
<221> MOD_RES
<222> (22)..(22)
<223> Trp or an analog of Trp

<220>
<221> MOD_RES
<222> (24)..(42)
<223> Any independently selected amino acid or amino
      acid analog

<220>
<221> misc_feature
<222> (24)..(42)
<223> This region may encompass 2 to 19 residues, wherein
      some residues may be absent

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 2
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Gln Asp Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  


<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Trp, an analog of Trp, or other amino acid or amino acid
      analog comprising at least one aromatic ring 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Trp, an analog of Trp, or other amino acid or amino acid
      analog comprising at least one aromatic ring 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 3
Xaa Gln Asp Xaa Gly 
1               5   


<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Trp, an analog of Trp, or other amino acid or amino acid 
      analog comprising at least one aromatic side chain 

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Trp, an analog of Trp, or other amino acid or amino acid 
      analog comprising at least one aromatic side chain 

<220>
<221> MOD_RES
<222> (6)..(6)
<223> His, Ala, analog of Ala, Phe, Trp or analog of Trp

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 4
Xaa Gln Asp Xaa Gly Xaa 
1               5       


<210> 5
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(3)
<223> Any independently selected amino acid or amino
      acid analog

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Trp or analog of Trp

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Trp or analog of Trp

<220>
<221> MOD_RES
<222> (9)..(13)
<223> Any independently selected amino acid or amino
      acid analog

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 5
Xaa Xaa Xaa Xaa Gln Asp Xaa Gly Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210> 6
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Ile, Val, Leu, B1-Ile, B1-Val, B1-Leu or a dipeptide 
      comprising Gly-Ile or B1-Gly-Ile, wherein B1 represents 
      a first blocking moiety 

<220>
<221> misc_feature
<222> (1)..(2)
<223> This region may encompass 1 to 2 residues, wherein some
      positions may be absent

<220>
<221> misc_feature
<222> (3)..(13)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Independently selected from Trp or analogs of Trp

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Independently selected from Trp or analogs of Trp

<220>
<221> MOD_RES
<222> (10)..(10)
<223> His, Ala or an analog of Ala, Phe, Trp or an analog 
      of Trp 

<220>
<221> MOD_RES
<222> (14)..(16)
<223> L-Thr, D-Thr, Ile, Val, Gly, a dipeptide selected from Thr-Ala
      or Thr-Asn, or a tripeptide comprising Thr-Ala-Asn, wherein
      a c-term -OH of any of the L-Thr, D-Thr, Ile, Val, Gly,
      Ala or Asn is optionally replaced by a second blocking moiety 

<220>
<221> misc_feature
<222> (14)..(16)
<223> This region may encompass 1 to 3 residues, wherein some
      positions may be absent 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 6
Xaa Xaa Cys Val Xaa Gln Asp Xaa Gly Xaa His Arg Cys Xaa Xaa Xaa 
1               5                   10                  15      


<210> 7
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Ile, Val, Leu, Ac-Ile, Ac-Val, Ac-Leu or a dipeptide
      comprising Gly-Ile or Ac-Gly-Ile

<220>
<221> misc_feature
<222> (1)..(2)
<223> This region may encompass 1 to 2 residues, wherein some
      positions may be absent

<220>
<221> misc_feature
<222> (3)..(13)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Independently selected from Trp or analogs of Trp 

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Independently selected from Trp or analogs of Trp 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> His, Ala or an analog of Ala, Phe, Trp or an analog
      of Trp 

<220>
<221> MOD_RES
<222> (14)..(16)	
<223> L-Thr, D-Thr, Ile, Val, Gly, a dipeptide selected from Thr-Ala
      or Thr-Asn, or a tripeptide comprising Thr-Ala-Asn, wherein a
      c-term -OH of any of L-Thr, D-Thr, Ile, Val, Gly, Ala, or Asn
      is optionally replaced by -NH2

<220>
<221> misc_feature
<222> (14)..(16)
<223> This region may encompass 1 to 3 residues, wherein some
      positions may be absent 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 7
Xaa Xaa Cys Val Xaa Gln Asp Xaa Gly Xaa His Arg Cys Xaa Xaa Xaa 
1               5                   10                  15      


<210> 8
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term H

<220>
<223> C-term CONH2

<400> 8
Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210> 9
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<223> C-term CONH2

<400> 9
Ile Cys Val Val Gln Asp Trp Gly His His Arg Cys Thr 
1               5                   10              


<210> 10
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<223> C-term CONH2

<400> 10
Ile Cys Val Tyr Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 11
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<223> C-term COOH

<400> 11
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 12
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<223> C-term CONH2

<400> 12
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 13
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (13)..(13)
<223> d-Thr

<220>
<223> C-term COOH

<400> 13
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 14
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 2-Nal

<220>
<223> C-term CONH2

<400> 14
Ile Cys Val Ala Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 15
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 2-Nal

<220>
<223> C-term COOH

<400> 15
Ile Cys Val Ala Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 16
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 1-Nal

<220>
<223> C-term COOH

<400> 16
Ile Cys Val Ala Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 17
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 2-Igl

<220>
<223> C-term CONH2

<400> 17
Ile Cys Val Gly Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 18
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 2-Igl

<220>
<223> C-term COOH

<400> 18
Ile Cys Val Gly Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 19
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Dht

<220>
<223> C-term COOH

<400> 19
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 20
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Bpa

<220>
<223> C-term COOH

<400> 20
Ile Cys Val Phe Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 21
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Bpa

<220>
<223> C-term CONH2

<400> 21
Ile Cys Val Phe Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 22
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Bta

<220>
<223> C-term COOH

<400> 22
Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 23
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Bta

<220>
<223> C-term CONH2

<400> 23
Ile Cys Val Xaa Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 24
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (9)..(9)
<223> 2-Abu

<220>
<223> C-term CONH2

<400> 24
Ile Cys Val Trp Gln Asp Trp Gly Xaa His Arg Cys Thr 
1               5                   10              


<210> 25
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term H

<220>
<223> C-term COOH

<400> 25
Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Ala Asn 
1               5                   10                  15      


<210> 26
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 5f-Trp

<220>
<223> C-term CONH2

<400> 26
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 27
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 5-methyl-Trp

<220>
<223> C-term CONH2

<400> 27
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 28
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 1-methyl-Trp

<220>
<223> C-term CONH2

<400> 28
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 29
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (7)..(7)
<223> 5f-Trp

<220>
<223> C-term CONH2

<400> 29
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 30
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 5f-Trp

<220>
<221> MOD_RES
<222> (7)..(7)
<223> 5f-Trp

<220>
<223> C-term CONH2

<400> 30
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 31
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 5-methyl-Trp

<220>
<221> MOD_RES
<222> (7)..(7)
<223> 5f-Trp

<220>
<223> C-term CONH2

<400> 31
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 32
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 1-methyl-Trp

<220>
<221> MOD_RES
<222> (7)..(7)
<223> 5f-Trp

<220>
<223> C-term CONH2

<400> 32
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 33
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term H

<220>
<221> MOD_RES
<222> (5)..(5)
<223> 6f-Trp

<220>
<221> MOD_RES
<222> (8)..(8)
<223> 6f-Trp

<220>
<223> C-term COOH

<400> 33
Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Asn 
1               5                   10                  15  


<210> 34
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 1-formyl-Trp

<220>
<223> C-term CONH2

<400> 34
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 35
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (4)..(4)
<223> 1-methoxy-Trp

<220>
<223> C-term CONH2

<400> 35
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 36
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term H

<220>
<221> MOD_RES
<222> (5)..(5)
<223> 5f-Trp

<220>
<221> MOD_RES
<222> (8)..(8)
<223> 5f-Trp

<220>
<223> C-term COOH

<400> 36
Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Asn 
1               5                   10                  15  


<210> 37
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp  

<400> 37
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 38
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)5-C(=O) 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 38
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 39
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term (C=O)-(CH2)5-maleimide 

<400> 39
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 40
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)2-C(=O)-NH-CH2CH2OCH2CH2O
      CH2CH2C(=O)

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 40
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 41
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)2-C(=O)-NH-CH2CH2OCH2CH2C(=O) 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 41
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 42
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)3-C(=O)-NH-CH2CH2OCH2CH2
      OCH2C(=O) 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 42
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 43
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)5-C(=O)-NH-CH2CH2OCH2CH2
      OCH2C(=O) 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 43
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 44
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)4-C(=O)-NH-CH2CH2OCH2CH2
      OCH2CH2C(=O) 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 44
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 45
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)2-C(=O)-NH-CH2CH2OCH2CH2
      OCH2CH2C(=O) 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 45
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 46
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Maleimide-(CH2)5-C(=O)-NH-CH2CH2OCH2CH2
      OCH2C(=O) 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 46
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 47
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 47
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 48
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 48
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Gly Gly Gly 
1               5                   10                  15      


Gly Gly Lys 
        


<210> 49
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term NH2(CH2)5C(=O) 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 49
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 50
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term NH2(CH2CH2O)2CH2C(=O) 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 50
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 51
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<221> MOD_RES
<222> (14)..(14)
<223> NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys 

<220> 
<223> C-term NH2 

<400> 51
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 52
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<221> MOD_RES
<222> (14)..(14)
<223> Lys-(C(=O)-(CH2)5-Mal) 

<220> 
<223> C-term NH2 

<400> 52
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 53
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<221> MOD_RES
<222> (19)..(19)
<223> Lys-(C(=O)-(CH2)5-Mal) 

<220> 
<223> C-term NH2 

<400> 53
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Gly Gly Gly 
1               5                   10                  15      


Gly Gly Lys 
            


<210> 54
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Mal-(CH2)5-(C(=O)-NH(CH2)5C(=O) 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 54
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 55
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Mal-(CH2)5-(C(=O)NH(CH2CH2O)2CH2C(=O) 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<223> C-term NH2 

<400> 55
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 56
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<221> MOD_RES
<222> (14)..(14)
<223> NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)5-Mal) 

<220> 
<223> C-term NH2 

<400> 56
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 57
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<221> MOD_RES
<222> (14)..(14)
<223> Lys-C(=O)-CH2(OCH2CH2)2NH(C(=O)-(CH2)5-Mal) 

<220> 
<223> C-term NH2 

<400> 57
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 58
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term (CH2CH2O)nC(=O)

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 58
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10              


<210> 59
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp

<220>
<221> MOD_RES
<222> (14)..(14)
<223> NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-C(=O)-(CH2CH2O)n

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 59
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 60
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Lys-C(=O)-(CH2CH2O)n

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 60
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 61
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Lys-C(=O)-(CH2CH2O)n

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 61
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Gly Gly Gly 
1               5                   10                  15      


Gly Gly Lys 
            


<210> 62
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (1)..(1)
<223> (CH2CH2O)nC(=O)Lys

<220>
<221> misc_feature
<222> (8)..(18)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (10)..(10)
<223> (1Me)Trp

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 62
Lys Gly Gly Gly Gly Gly Ile Cys Val Trp Gln Asp Trp Gly Ala His 
1               5                   10                  15      


Arg Cys Thr 
            


<210> 63
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> MOD_RES
<222> (1)..(1)
<223> (CH2CH2O)nC(=O)Lys

<220>
<221> misc_feature
<222> (3)..(13)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (5)..(5)
<223> (1Me)Trp

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 63
Lys Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr 
1               5                   10                  


<210> 64
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp

<220>
<221> MOD_RES
<222> (14)..(14)
<223> NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2CH2O)n-R)

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 64
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 65
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp

<220>
<221> MOD_RES
<222> (14)..(14)
<223> NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)m-
      (CH2CH2O)n-R)

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 65
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 66
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220>
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp

<220>
<221> MOD_RES
<222> (14)..(14)
<223> NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)m-C(=O)-
     (CH2CH2O)n-R)

<220>
<223> C-term NH2

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 66
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 67
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220> 
<223> N-term Ac 

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220> 
<221> MOD_RES
<222> (4)..(4)
<223> (1Me)Trp 

<220> 
<221> MOD_RES
<222> (14)..(14)
<223> NH-CH2CH2OCH2CH2OCH2-C(=O)-Lys-(C(=O)-(CH2)m-C(=O)
      -(CH2)j(CH2CH2O)n-R) 

<220> 
<223> C-term NH2 

<400> 67
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 68
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<223> N-term Ac

<220> 
<221> misc_feature
<222> (2)..(12)
<223> Disulfide bond 

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> (1Me)Trp  

<220>
<221> misc_feature
<222> (13)..(14) 
<223> Residues at these positions are linked by an AEEAc moiety

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Lys-(C(=O)-(CH2)5-Mal)

<220>
<223> C-term NH2

<400> 68
Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Thr Lys 
1               5                   10                  


<210> 69
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 69
His His His His His His 
1               5       


<210> 70
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(4)
<223> Any independently selected amino acid or amino
      acid analog

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Trp or analog of Trp

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Trp or analog of Trp

<220>
<221> MOD_RES
<222> (10)..(14)
<223> Any independently selected amino acid or amino
      acid analog

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 70
Xaa Xaa Xaa Xaa Xaa Gln Asp Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210> 71
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(3)
<223> Ile, Val, Leu, B1-Ile, B1-Val, B1-Leu or a dipeptide 
      comprising Gly-Ile or B1-Gly-Ile, wherein B1 represents 
      a first blocking moiety 

<220>
<221> misc_feature
<222> (2)..(3)
<223> This region may encompass 1 to 2 residues, wherein some
      positions may be absent

<220>
<221> misc_feature
<222> (4)..(14)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (6)..(6)
<223> Independently selected from Trp or analogs of Trp

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Independently selected from Trp or analogs of Trp

<220>
<221> MOD_RES
<222> (11)..(11)
<223> His, Ala or an analog of Ala, Phe, Trp or an analog 
      of Trp 

<220>
<221> MOD_RES
<222> (15)..(17)
<223> L-Thr, D-Thr, Ile, Val, Gly, a dipeptide selected from Thr-Ala
      or Thr-Asn, or a tripeptide comprising Thr-Ala-Asn, wherein
      a C-term -OH of any of the L-Thr, D-Thr, Ile, Val, Gly,
      Ala or Asn is optionally replaced by a second blocking moiety 

<220>
<221> misc_feature
<222> (15)..(17)
<223> This region may encompass 1 to 3 residues, wherein some
      positions may be absent 

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 71
Xaa Xaa Xaa Cys Val Xaa Gln Asp Xaa Gly Xaa His Arg Cys Xaa Xaa 
1               5                   10                  15      


Xaa Xaa 
        


<210> 72
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1) 
<223> Any amino acid

<220>
<221> MOD_RES
<222> (2)..(2) 
<223> Ile or Gly

<220>
<221> MOD_RES
<222> (3)..(3) 
<223> Ile or Cys

<220>
<221> MOD_RES
<222> (4)..(4) 
<223> Val or Cys
     
<220>
<221> MOD_RES
<222> (5)..(5) 
<223> Val, Tyr, Trp, 2-Nal, 1-Nal, 2-Igl, Dht, Bpa, Bta,  
      5f-Trp, 5-methyl-Trp, 1-methyl-Trp, 1-formyl-Trp or 
      1-methyoxy-Trp

<220>
<221> MOD_RES
<222> (6)..(6) 
<223> Gln, Trp, 6f-Trp or 5f-Trp

<220>
<221> MOD_RES
<222> (7)..(7) 
<223> Asp or Gln

<220>
<221> MOD_RES
<222> (8)..(8) 
<223> Trp, Asp or 5f-Trp

<220>
<221> MOD_RES
<222> (9)..(9) 
<223> Gly, Trp, 6f-Trp or 5f-Trp

<220>
<221> MOD_RES
<222> (10)..(10) 
<223> His, Ala, 2-Abu or Gly

<220>
<221> MOD_RES
<222> (11)..(11) 
<223> His or Ala

<220>
<221> MOD_RES
<222> (12)..(12) 
<223> Arg or His

<220>
<221> MOD_RES
<222> (13)..(13) 
<223> Cys or Arg

<220>
<221> MOD_RES
<222> (14)..(14) 
<223> Thr, D-Thr or Cys

<220>
<221> MOD_RES
<222> (15)..(15) 
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 72
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210> 73
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> misc_feature
<222> (3)..(13)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Trp(Me)

<220>
<221> MOD_RES
<222> (9)..(9)
<223> mGly

<220>
<221> MOD_RES
<222> (14)..(14)
<223> mIle

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 73
Xaa Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile Xaa 
1               5                   10                  15  


<210> 74
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any amino acid

<220>
<221> misc_feature
<222> (3)..(13)
<223> Disulfide bond

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Trp(Me)

<220>
<221> MOD_RES
<222> (9)..(9)
<223> mGly

<220>
<221> MOD_RES
<222> (14)..(14)
<223> mIle

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Any amino acid

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 74
Xaa Ile Cys Val Trp Gln Asp Trp Gly Ala His Arg Cys Ile Xaa 
1               5                   10                  15  

