                         SEQUENCE LISTING

<110>  Ionis Pharmaceuticals, Inc.
 
<120>  CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE

<130>  CORE0145WO

<150>  62/598,926
<151>  2017-12-14

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  14411
<212>  DNA
<213>  Homo sapien

<400>  1
ctcccagccc agcgcctccc accccttttc atagcaggaa aagccggagc ccagggaggg       60

aacggacctg cgagtcacac aactggtgac ccacaccagc ggctggagca ggaccctctt      120

ggggagaaga gcatcctgcc cgcagccagg gcccctcatc aaagtcctcg gtgtttttta      180

aattatcaga actgcccagg accacgtttc ccaggccctg cccagctggg actcctcggt      240

ccttgcctcc tagtttctca ggcctggccc tctcaaggcc caggcacccc aggccggttg      300

gaggccccga cttccactct ggagaaccgt ccaccctgga aagaagagct cagattcctc      360

ttggctctcg gagccgcagg gagtgtgtct tcccgcgcca ccctccaccc cccgaaatgt      420

ttctgtttct aatcccagcc tgggcaggaa tgtggctccc cggccagggg ccaaggagct      480

attttggggt ctcgtttgcc cagggagggc ttggctccac cactttcctc ccccagcctt      540

tgggcagcag gtcacccctg ttcaggctct gagggtgccc cctcctggtc ctgtcctcac      600

caccccttcc ccacctcctg ggaaaaaaaa aaaaaaaaaa aaaaaaagct ggtataaagc      660

agagagcctg agggctaaat ttaactgtcc gagtcggaat ccatctctga gtcacccaag      720

aagctgccct ggcctcccgt ccccttccca ggcctcaacc cctttctccc acccagcccc      780

aacccccagc cctcaccccc tagcccccag ttctggagct tgtcgggagc aagggggtgg      840

ttgctactgg gtcactcagc ctcaattggc cctgtttcag caatgggcag gttcttcttg      900

aaattcatca cacctgtggc ttcctctgtg ctctaccttt ttattggggt gacagtgtga      960

cagctgagat tctccatgca ttccccctac tctagcactg aagggttctg aagggccctg     1020

gaaggaggga gcttgggggg ctggcttgtg aggggttaag gctgggaggc gggagggggg     1080

ctggaccaag gggtggggag aaggggagga ggcctcggcc ggccgcagag agaagtggcc     1140

agagaggccc aggggacagc cagggacagg cagacatgca gccagggctc cagggcctgg     1200

acaggggctg ccaggccctg tgacaggagg accccgagcc cccggcccgg ggaggggcca     1260

tggtgctgcc tgtccaacat gtcagccgag gtgcggctga ggcggctcca gcagctggtg     1320

ttggacccgg gcttcctggg gctggagccc ctgctcgacc ttctcctggg cgtccaccag     1380

gagctgggcg cctccgaact ggcccaggac aagtacgtgg ccgacttctt gcagtggggt     1440

gagtgcctac cctcggggct cctgcagatg gggtgggggt ggggcaggag acaggtctgg     1500

gcacagaggc ctggctgttg ggggggcagg atggcaggat gggcatgggg agatcctccc     1560

atcctggggc tcagagtgtg gacctgggcc ctggggcaac atttctctgt cctatgccac     1620

cactctggag gggcagagta aggtcagcag aggctagggt ggctgtgact cagagccatg     1680

gcttaggagt cacagcaggc taggctgcca acagcctccc atggcctctc tgcaccccgc     1740

ctcagggtca gggtcagggt catgctggga gctccctctc ctaggaccct ccccccaaaa     1800

gtgggctcta tggccctctc ccctggtttc ctgtggcctg gggcaagcca ggagggccag     1860

catggggcag ctgccagggg cgcagccgac aggcaggtgt tcggcgccag cctctccagc     1920

tgccccaaca ggtgcccagg cactgggagg gcggtgactc acgcgggccc tgtgggagaa     1980

ccagctttgc agacaggcgc caccagtgcc ccctcctctg cgatccagga gggacaactt     2040

tgggttcttc tgggtgtgtc tccttctttt gtaggttctg cacccacccc cacccccagc     2100

cccaaagtct cggttcctat gagccgtgtg ggtcagccac cattcccgcc accccgggtc     2160

cctgcgtcct ttagttctcc tggcccaggg cctccaacct tccagctgtc ccacaaaacc     2220

ccttcttgca agggctttcc agggcctggg gccagggctg gaaggaggat gcttccgctt     2280

ctgccagctg ccttgtctgc ccacctcctc cccaagccca ggactcgggc tcactggtca     2340

ctggtttctt tcattcccag caccctgccc ctctggccct catatgtctg gccctcagtg     2400

actggtgttt ggtttttggc ctgtgtgtaa caaactgtgt gtgacacttg tttcctgttt     2460

ctccgccttc ccctgcttcc tcttgtgtcc atctctttct gacccaggcc tggttccttt     2520

ccctcctcct cccatttcac agatgggaag gtggaggcca agaagggcca ggccattcag     2580

cctctggaaa aaccttctcc caacctccca cagcccctaa tgactctcct ggcctccctt     2640

tagtagagga tgaagttggg ttggcagggt aaactgagac cgggtggggt aggggtctgg     2700

cgctcccggg aggagcactc cttttgtggc ccgagctgca tctcgcggcc cctcccctgc     2760

caggcctggg gcgggggagg gggccagggt tcctgctgcc ttaaaagggc tcaatgtctt     2820

ggctctctcc tccctccccc gtcctcagcc ctggctggtt cgtccctgct ggcccactct     2880

cccggaaccc cccggaaccc ctctctttcc tccagaaccc actgtctcct ctccttccct     2940

cccctcccat acccatccct ctctccatcc tgcctccact tcttccaccc ccgggagtcc     3000

aggcctccct gtccccacag tccctgagcc acaagcctcc accccagctg gtcccccacc     3060

caggctgccc agtttaacat tcctagtcat aggaccttga cttctgagag gcctgattgt     3120

catctgtaaa taaggggtag gactaaagca ctcctcctgg aggactgaga gatgggctgg     3180

accggagcac ttgagtctgg gatatgtgac catgctacct ttgtctccct gtcctgttcc     3240

ttcccccagc cccaaatcca gggttttcca aagtgtggtt caagaaccac ctgcatctga     3300

atctagaggt actggataca accccacgtc tgggccgtta cccaggacat tctacatgag     3360

aacgtggggg tggggccctg gctgcacctg aactgtcacc tggagtcagg gtggaaggtg     3420

gaagaactgg gtcttatttc cttctcccct tgttctttag ggtctgtcct tctgcagact     3480

ccgttacccc accctaacca tcctgcacac ccttggagcc ctctgggcca atgccctgtc     3540

ccgcaaaggg cttctcaggc atctcacctc tatgggaggg catttttggc ccccagaacc     3600

ttacacggtg tttatgtggg gaagcccctg ggaagcagac agtcctaggg tgaagctgag     3660

aggcagagag aaggggagac agacagaggg tggggctttc ccccttgtct ccagtgccct     3720

ttctggtgac cctcggttct tttcccccac caccccccca gcggagccca tcgtggtgag     3780

gcttaaggag gtccgactgc agagggacga cttcgagatt ctgaaggtga tcggacgcgg     3840

ggcgttcagc gaggtaagcc gaaccgggcg ggagcctgac ttgactcgtg gtgggcgggg     3900

cataggggtt ggggcggggc cttagaaatt gatgaatgac cgagccttag aacctagggc     3960

tgggctggag gcggggcttg ggaccaatgg gcgtggtgtg gcaggtgggg cggggccacg     4020

gctgggtgca gaagcgggtg gagttgggtc tgggcgagcc cttttgtttt cccgccgtct     4080

ccactctgtc tcactatctc gacctcaggt agcggtagtg aagatgaagc agacgggcca     4140

ggtgtatgcc atgaagatca tgaacaagtg ggacatgctg aagaggggcg aggtgagggg     4200

ctgggcggac gtggggggct ttgaggatcc gcgccccgtc tccggctgca gctcctccgg     4260

gtgccctgca ggtgtcgtgc ttccgtgagg agagggacgt gttggtgaat ggggaccggc     4320

ggtggatcac gcagctgcac ttcgccttcc aggatgagaa ctacctggtg agctccgggc     4380

cggggtgact aggaagaggg acaagagccc gtgctgtcac tggacgagga ggtggggaga     4440

ggaagctcta ggattggggg tgctgcccgg aaacgtctgt gggaaagtct gtgtgcggta     4500

agagggtgtg tcaggtggat gaggggcctt ccctatctga gacggggatg gtgtccttca     4560

ctgcccgttt ctggggtgat ctgggggact cttataaaga tgtctctgtt gcggggggtc     4620

tcttacctgg aatgggatag gtcttcagga attctaacgg ggccactgcc tagggaagga     4680

gtgtctggga cctattctct gggtgttggg tggcctctgg gttctctttc ccagaacatc     4740

tcagggggag tgaatctgcc cagtgacatc ccaggaaagt ttttttgttt gtgttttttt     4800

ttgaggggcg ggggcggggg ccgcaggtgg tctctgattt ggcccggcag atctctatgg     4860

ttatctctgg gctggggctg caggtctctg cccaaggatg gggtgtctct gggaggggtt     4920

gtcccagcca tccgtgatgg atcagggcct caggggacta ccaaccaccc atgacgaacc     4980

ccttctcagt acctggtcat ggagtattac gtgggcgggg acctgctgac actgctgagc     5040

aagtttgggg agcggattcc ggccgagatg gcgcgcttct acctggcgga gattgtcatg     5100

gccatagact cggtgcaccg gcttggctac gtgcacaggt gggtgcagca tggccgaggg     5160

gatagcaagc ttgttccctg gccgggttct tggaaggtca gagcccagag aggccagggc     5220

ctggagaggg accttcttgg ttggggccca ccggggggtg cctgggagta ggggtcagaa     5280

ctgtagaagc cctacagggg cggaacccga ggaagtgggg tcccaggtgg cactgcccgg     5340

aggggcggag cctggtggga ccacagaagg gaggttcatt tatcccaccc ttctcttttc     5400

ctccgtgcag ggacatcaaa cccgacaaca tcctgctgga ccgctgtggc cacatccgcc     5460

tggccgactt cggctcttgc ctcaagctgc gggcagatgg aacggtgagc cagtgccctg     5520

gccacagagc aactggggct gctgatgagg gatggaaggc acagagtgtg ggagcgggac     5580

tggatttgga ggggaaaaga ggtggtgtga cccaggctta agtgtgcatc tgtgtggcgg     5640

agtattagac caggcagagg gaggggctaa gcatttgggg agtggttgga aggagggccc     5700

agagctggtg ggcccagagg ggtgggccca agcctcgctc tgctcctttt ggtccaggtg     5760

cggtcgctgg tggctgtggg caccccagac tacctgtccc ccgagatcct gcaggctgtg     5820

ggcggtgggc ctgggacagg cagctacggg cccgagtgtg actggtgggc gctgggtgta     5880

ttcgcctatg aaatgttcta tgggcagacg cccttctacg cggattccac ggcggagacc     5940

tatggcaaga tcgtccacta caaggtgagc acggccgcag ggagacctgg cctctcccgg     6000

taggcgctcc caggctatcg cctcctctcc ctctgagcag gagcacctct ctctgccgct     6060

ggtggacgaa ggggtccctg aggaggctcg agacttcatt cagcggttgc tgtgtccccc     6120

ggagacacgg ctgggccggg gtggagcagg cgacttccgg acacatccct tcttctttgg     6180

cctcgactgg gatggtctcc gggacagcgt gccccccttt acaccggatt tcgaaggtgc     6240

caccgacaca tgcaacttcg acttggtgga ggacgggctc actgccatgg tgagcggggg     6300

cggggtaggt acctgtggcc cctgctcggc tgcgggaacc tccccatgct ccctccataa     6360

agttggagta aggacagtgc ctaccttctg gggtcctgaa tcactcattc cccagagcac     6420

ctgctctgtg cccatctact actgaggacc cagcagtgac ctagacttac agtccagtgg     6480

gggaacacag agcagtcttc agacagtaag gccccagagt gatcagggct gagacaatgg     6540

agtgcagggg gtgggggact cctgactcag caaggaaggt cctggagggc tttctggagt     6600

ggggagctat ctgagctgag acttggaggg atgagaagca ggagaggact cctcctccct     6660

taggccgtct ctcttcaccg tgtaacaagc tgtcatggca tgcttgctcg gctctgggtg     6720

cccttttgct gaacaatact ggggatccag cacggaccag atgagctctg gtccctgccc     6780

tcatccagtt gcagtctaga gaattagaga attatggaga gtgtggcagg tgccctgaag     6840

ggaagcaaca ggatacaaga aaaaatgatg gggccaggca cggtggctca cgcctgtaac     6900

cccagcaatt tggcaggccg aagtgggtgg attgcttgag cccaggagtt cgagaccagc     6960

ctgggcaatg tggtgagacc cccgtctcta caaaaatgtt ttaaaaattg gttgggcgtg     7020

gtggcgcatg cctgtatact cagctactag ggtggccgac gtgggcttga gcccaggagg     7080

tcaaggctgc agtgagctgt gattgtgcca ctgcactcca gcctgggcaa cggagagaga     7140

ctctgtctca aaaataagat aaactgaaat taaaaaatag gctgggctgg ccgggcgtgg     7200

tggctcacgc ctgtaatctc agcactttgg gaggccgagg cgggtggatc acgaggtcag     7260

gagatcgaga ccatcttggc taacacggtg aaaccccatc tctcctaaaa atacaaaaaa     7320

ttagccaggc gtggtggcgg gcgcctgtag tcccagctac tcaggaggct gaggcaggag     7380

aatggcgtga acccgggagg cagagtttgc agtgagccga gatcgtgcca ctgcactcca     7440

gcctgggcga cagagcgaga ctctgtctca gaaaaaaaaa aaaaaaaaaa aaaaaatagg     7500

ctggaccgcg gccgggcgct gtggctcatg cctgtaatcc cagcactttg ggagtccaag     7560

gccggtgggt catgagatca ggagttttga gactaggctg gccaacacgg tgaaaccccg     7620

tctctactaa aaatacaaga aaattagctg ggtgtggtct cgggtgcctg taattccagt     7680

tactggggaa gctgaggcag gagaattgct tgaacctggg aggcagagtt tgcagtgagc     7740

caagatcatg ccactacact ccagtctggg tgacagagtg agactctgtc tcaaaaaaaa     7800

aaaaaaaaaa aagggttggg caaggtggtt cacgcctgta atcccagaac tttgggaggc     7860

tgaggcaggc agatcactgg aagtcaggag ttcaagacca gcctggccaa catggtgaaa     7920

ccctgtgtct actaaaaata caaaatttag ccaggcttgg tggcgtatgc ctgtaatgcc     7980

agctactcag gaggctgagg caggagaatc gcttgattga acctgggagg cagagtttgc     8040

agtgggctgg ggttgtgcca ctgcactcta ggctgggaga cagcaagact ccatctaaaa     8100

aaaaaaaaca gaactgggct gggcacagtg gcttatattt gtaatcccag cactttggga     8160

ggctgaggtt ggaggactgc ttgagcccag agtttgggac tacaacagct gaggtaggcg     8220

gatcacttga ggtcagaaga tggagaccag cctggccagc gtggcgaaac cccgtctcta     8280

ccaaaaatat aaaaaattag ccaggcgtgg tagagggcgc ctgtaatctc agctactcag     8340

gacgctgagg caggagaatc gcctgaacct gggaggcgga ggttgcagtg agctgagatt     8400

gcaccactgc actccagcct gggtaacaga gcgagactcc gtatcaaaga aaaagaaaaa     8460

agaaaaaatg ctggaggggc cactttagat aagccctgag ttggggctgg tttgggggga     8520

acatgtaagc caagatcaaa aagcagtgag gggcccgccc tgacgactgc tgctcacatc     8580

tgtgtgtctt gcgcaggaga cactgtcgga cattcgggaa ggtgcgccgc taggggtcca     8640

cctgcctttt gtgggctact cctactcctg catggccctc aggtaagcac tgccctggac     8700

ggcctccagg ggccacgagg ctgcttgagc ttcctgggtc ctgctccttg gcagccaatg     8760

gagttgcagg atcagtcttg gaaccttact gttttgggcc caaagactcc taagaggcca     8820

gagttggagg accttaaatt ttcagatcta tgtacttcaa aatgttagat tgaattttaa     8880

aacctcagag tcacagactg ggcttcccag aatcttgtaa ccattaactt ttacgtctgt     8940

agtacacaga gccacaggac ttcagaactt ggaaaatatg aagtttagac ttttacaatc     9000

agttgtaaaa gaatgcaaat tctttgaatc agccatataa caataaggcc atttaaaagt     9060

attaatttag gcgggccgcg gtggctcacg cctgtaatcc tagcactttg ggaggccaag     9120

gcaggtggat catgaggtca ggagatcgag accatcctgg ctaacacggt gaaaccccgt     9180

ctctactaaa aatacaaaaa aattagccgg gcatggtggc gggcgcttgc ggtcccagct     9240

acttgggagg cgaggcagga gaatggcatg aacccgggag gcggagcttg cagtgagccg     9300

agatcatgcc actgcactcc agcctgggcg acagagcaag actccgtctc aaaaaaaaaa     9360

aaaaaaaagt atttatttag gccgggtgtg gtggctcacg cctgtaattc cagtgctttg     9420

ggaggatgag gtgggtggat cacctgaggt caggagttcg agaccagcct gaccaacgtg     9480

gagaaacctc atctctacta aaaaacaaaa ttagccaggc gtggtggcat atacctgtaa     9540

tcccagctac tcaggaggct gaggcaggag aatcagaacc caggaggggg aggttgtggt     9600

gagctgagat cgtgccattg cattccagcc tgggcaacaa gagtgaaact tcatctcaaa     9660

aaaaaaaaaa aaaaagtact aatttacagg ctgggcatgg tggctcacgc ttggaatccc     9720

agcactttgg gaggctgaag tggacggatt gcttcagccc aggagttcaa gaccagcctg     9780

agcaacataa tgagaccctg tctctacaaa aaattgaaaa aatcgtgcca ggcatggtgg     9840

tctgtgcctg cagtcctagc tactcaggag tctgaagtag gagaatcact tgagcctgga     9900

gtttgaggct tcagtgagcc atgatagatt ccagcctagg caacaaagtg agacctggtc     9960

tcaacaaaag tattaattac acaaataatg cattgcttat cacaagtaaa ttagaaaata    10020

cagataagga aaaggaagtt gatatctcgt gagctcacca gatggcagtg gtccctggct    10080

cacacgtgta ctgacacatg tttaaatagt ggagaacagg tgtttttttg gtttgttttt    10140

ttccccttcc tcatgctact ttgtctaaga gaacagttgg ttttctagtc agcttttatt    10200

actggacaac attacacata ctatacctta tcattaatga actccagctt gattctgaac    10260

cgctgcgggg cctgaacggt gggtcaggat tgaacccatc ctctattaga acccaggcgc    10320

atgtccagga tagctaggtc ctgagccgtg ttcccacagg agggactgct gggttggagg    10380

ggacagccac ttcatacccc agggaggagc tgtccccttc ccacagctga gtggggtgtg    10440

ctgacctcaa gttgccatct tggggtccca tgcccagtct taggaccaca tctgtggagg    10500

tggccagagc caagcagtct ccccatcagg tcggcctccc tgtcctgagg ccctgagaag    10560

aggggtctgc agcggtcaca tgtcaaggga ggagatgagc tgaccctaga acatgggggt    10620

ctggacccca agtccctgca gaaggtttag aaagagcagc tcccaggggc ccaaggccag    10680

gagaggggca gggcttttcc taagcagagg aggggctatt ggcctacctg ggactctgtt    10740

ctcttcgctc tgctgctccc cttcctcaaa tcaggaggtc ttggaagcag ctgcccctac    10800

ccacaggcca gaagttctgg ttctccacca gagaatcagc attctgtctc cctccccact    10860

ccctcctcct ctccccaggg acagtgaggt cccaggcccc acacccatgg aactggaggc    10920

cgagcagctg cttgagccac acgtgcaagc gcccagcctg gagccctcgg tgtccccaca    10980

ggatgaaaca gtaagttggt ggaggggagg gggtccgtca gggacaattg ggagagaaaa    11040

ggtgagggct tcccgggtgg cgtgcactgt agagccctct agggacttcc tgaacagaag    11100

cagacagaaa ccacggagag acgaggttac ttcagacatg ggacggtctc tgtagttaca    11160

gtggggcatt aagtaagggt gtgtgtgttg ctggggatct gagaagtcga tctttgagct    11220

gagcgctggt gaaggagaaa caagccatgg aaggaaaggt gccaagtggt caggcgagag    11280

cctccagggc aaaggccttg ggcaggtggg aatcctgatt tgttcctgaa aggtagtttg    11340

gctgaatcat tcctgagaag gctggagagg ccagcaggaa acaaaaccca gcaaggcctt    11400

ttgtcgtgag ggcattaggg agctggaggg attttgagca gcagagggac ataggttgtg    11460

ttagtgtttg agcaccagcc ctctggtccc tgtgtagatt tagaggacca gactcaggga    11520

tggggctgag ggaggtaggg aagggagggg gcttggatca ttgcaggagc tatggggatt    11580

ccagaaatgt tgaggggacg gaggagtagg ggataaacaa ggattcctag cctggaacca    11640

gtgcccaagt cctgagtctt ccaggagcca caggcagcct taagcctggt ccccatacac    11700

aggctgaagt ggcagttcca gcggctgtcc ctgcggcaga ggctgaggcc gaggtgacgc    11760

tgcgggagct ccaggaagcc ctggaggagg aggtgctcac ccggcagagc ctgagccggg    11820

agatggaggc catccgcacg gacaaccaga acttcgccag gtcgggatcg gggccggggc    11880

cggggccggg atgcgggccg gtggcaaccc ttggcatccc ctctcgtccg gcccggacgg    11940

actcaccgtc cttacctccc cacagtcaac tacgcgaggc agaggctcgg aaccgggacc    12000

tagaggcaca cgtccggcag ttgcaggagc ggatggagtt gctgcaggca gagggagcca    12060

caggtgagtc cctcatgtgt ccccttcccc ggaggaccgg gaggaggtgg gccgtctgct    12120

ccgcggggcg tgtatagaca cctggaggag ggaagggacc cacgctgggg cacgccgcgc    12180

caccgccctc cttcgcccct ccacgcgccc tatgcctctt tcttctcctt ccagctgtca    12240

cgggggtccc cagtccccgg gccacggatc caccttccca tgtaagaccc ctctctttcc    12300

cctgcctcag acctgctgcc cattctgcag atcccctccc tggctcctgg tctccccgtc    12360

cagatatagg gctcacccta cgtctttgcg actttagagg gcagaagccc tttattcagc    12420

cccagatctc cctccgttca ggcctcacca gattccctcc gggatctccc tagataacct    12480

ccccaacctc gattcccctc gctgtctctc gccccaccgc tgagggctgg gctgggctcc    12540

gatcgggtca cctgtccctt ctctctccag ctagatggcc ccccggccgt ggctgtgggc    12600

cagtgcccgc tggtggggcc aggccccatg caccgccgcc acctgctgct ccctgccagg    12660

gtacgtccgg ctgcccacgc ccccctccgc cgtcgcgccc cgcgctccac ccgccccttg    12720

ccacccgctt agctgcgcat ttgcggggct gggcccacgg caggagggcg gatcttcggg    12780

cagccaatca acacaggccg ctaggaagca gccaatgacg agttcggacg ggattcgagg    12840

cgtgcgagtg gactaacaac agctgtaggc tgttggggcg ggggcggggc gcagggaaga    12900

gtgcgggccc acctatgggc gtaggcgggg cgagtcccag gagccaatca gaggcccatg    12960

ccgggtgttg acctcgccct ctccccgcag gtccctaggc ctggcctatc ggaggcgctt    13020

tccctgctcc tgttcgccgt tgttctgtct cgtgccgccg ccctgggctg cattgggttg    13080

gtggcccacg ccggccaact caccgcagtc tggcgccgcc caggagccgc ccgcgctccc    13140

tgaaccctag aactgtcttc gactccgggg ccccgttgga agactgagtg cccggggcac    13200

ggcacagaag ccgcgcccac cgcctgccag ttcacaaccg ctccgagcgt gggtctccgc    13260

ccagctccag tcctgtgatc cgggcccgcc ccctagcggc cggggaggga ggggccgggt    13320

ccgcggccgg cgaacggggc tcgaagggtc cttgtagccg ggaatgctgc tgctgctgct    13380

gctgctgctg ctgctgctgc tgctgctgct gctgctgctg ctgctggggg gatcacagac    13440

catttctttc tttcggccag gctgaggccc tgacgtggat gggcaaactg caggcctggg    13500

aaggcagcaa gccgggccgt ccgtgttcca tcctccacgc acccccacct atcgttggtt    13560

cgcaaagtgc aaagctttct tgtgcatgac gccctgctct ggggagcgtc tggcgcgatc    13620

tctgcctgct tactcgggaa atttgctttt gccaaacccg ctttttcggg gatcccgcgc    13680

ccccctcctc acttgcgctg ctctcggagc cccagccggc tccgcccgct tcggcggttt    13740

ggatatttat tgacctcgtc ctccgactcg ctgacaggct acaggacccc caacaacccc    13800

aatccacgtt ttggatgcac tgagaccccg acattcctcg gtatttattg tctgtcccca    13860

cctaggaccc ccacccccga ccctcgcgaa taaaaggccc tccatctgcc caaagctctg    13920

gactccacag tgtccgcggt ttgcgttgtg ggccggaggc tccgcagcgg gccaatccgg    13980

aggcgtgtgg aggcggccga aggtctggga ggagctagcg ggatgcgaag cggccgaatc    14040

agggttgggg gaggaaaagc cacggggcgg ggctttggcg tccggccaat aggagggcga    14100

gcgggccacc cggaggcacc gcccccgccc agctgtggcc cagctgtgcc accgagcgtc    14160

gagaagaggg ggctgggctg gcagcgcgcg cggccatcct ccttccactg cgcctgcgca    14220

cgccacgcgc atccgctcct gggacgcaag ctcgagaaaa gttgctgcaa actttctagc    14280

ccgttccccg cccctcctcc cggccagacc cgccccccct gcggagccgg gaattccgag    14340

gggcggagcg caggccgaga tggggaatgt gggggcctgc agaggaccct ggagacggag    14400

gcgtgcagaa g                                                         14411


<210>  2
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  2
acaataaata ccgagg                                                       16


<210>  3
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  3
tcaacaataa ataccgagg                                                    19


<210>  4
<211>  8
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonuclotide

<400>  4
cctcggta                                                                 8


<210>  5
<211>  9
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  5
atttattgt                                                                9


<210>  6
<211>  16
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  6
ccucgguauu uauugu                                                       16


<210>  7
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucletide

<400>  7
ttgtgttcac aataaatacc gagg                                              24


<210>  8
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  8
acaataaatc cgagggttcc ctc                                               23


<210>  9
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  9
ggagccataa ataacacttg tgtt                                              24


<210>  10
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  10
cctcggtatt tattgt                                                       16


<210>  11
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  11
tcaccucggu auuuauugu                                                    19


<210>  12
<211>  16
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  12
ccucgguauu uauugu                                                       16


<210>  13
<211>  16
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  13
ctagttcact gaatgc                                                       16


<210>  14
<211>  8
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  14
gcattcag                                                                 8


<210>  15
<211>  9
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  15
gtgaactag                                                                9


<210>  16
<211>  8
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  16
tgaactag                                                                 8


<210>  17
<211>  11
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  17
cagugaacua g                                                            11


<210>  18
<211>  10
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  18
ctagttgcat                                                              10


<210>  19
<211>  10001
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<222>  (2)..(19)
<223>  bases at these positions are RNA

<400>  19
tgactatcag cctgtatggt cattaagttc tgtctaccct gggaaagcct ctgcccaaac       60

ctccctattc acaggtccta gaacgtagag gtggggagca ggacggtgcc gccaggccgt      120

gtgcgatcgc gagctctgga tctcaatgcg ccccggggcg ctgtttccca cgactccagc      180

agcttttcta aaaatccagg cagcctccag tttacgggat caacccgaga ctcgcttccc      240

tttgaaaatt ctagagtata aagtaaacgt acgagcaaag tatgtgtctt aacacttaat      300

ggatgacata gagaccaaaa aagccatgtc cgtgggccca gtaggccgca ataaggggcg      360

accaggaaac tgcagcacag ccccccgcag ccgccctgct cccacaccag tcattccagc      420

accgtggtga aggcgcttgg gggcggggcg gggcgcgcct gcgcagcgag gctctgcagc      480

agaaactttg cctagaccgg ctggaaccgg ttagaaccgg tcgaacccgg ccggctgcca      540

gccctcgatt cagcagctca caaagggagg cggcgactca cgacccgcgt atccttgcgc      600

ctctccccac cccctttgtc ctcgcgacgg gttccgcggt cctccccgcc ctccctggcg      660

cggcccccgc tttctgcgcc cagtgacgct ttctccatgg tcctgggaga aagagaaaaa      720

catcctttcc cctccgtcgt agttttagga agcgatgaga tagacctggg gaccttgccg      780

ccacgggccg ggctctgacg gttattagcg cagtgcgggt ggtgctcggc atggccgcca      840

aggtcgccgt gccctcacct gcagcgacca tggccttgct gggctgagac cgcagcctaa      900

catggcggac gtaggcaagc accaaagcgc tcgtgtaccc gggctcggaa aagtggcccc      960

gagagcagcc ggaggctgca ggtcgtccct acaggagcat tcccagtata aaccagtaca     1020

aagtgtcacc acctcagaag ccactcgcag ggccggtcac tttccgagag acctccatct     1080

tgtttcgcat gaaatggcag ccgctcgggg agttacaaaa tgggaagtgg aagctgaagc     1140

tgtgggaaag cctgttttaa cacttgcaac atacgctata ccctctgtcc tcccaggaaa     1200

acgcaaaagg tgttgaaaca tctgaaaaac ttggggctcc catttttaat agctattagt     1260

tcatgttttt tctccttgtg accagaaatt ttaaacctat ttgtacctat ttagctggta     1320

caagctaaac atttctctgt attagcaagg tccaagaggc ccacacgacg tcaagaaaaa     1380

tctagaaact tggaagtcag gatctatttt taactctctg aggaactatt tttcttcctt     1440

caccaaggtg gtggagggtt actaggttcc ggtggagtga cgtgtccctt tgcaataaat     1500

accggcgctc cgggctctgc gtcaggcatt caggcagcga gagcagagca gcgtagagca     1560

gcacagctga gctcgtgagg caggagactc agcccgagga aatcgcagat aagtttttaa     1620

ttaaaaagat tgagcagtaa aaagaattag aactctaaac ttaagctaat agagtagctt     1680

atcgaaatat tacttagtct taataatcta agaagatctt aagagataac atgaaggctt     1740

atttaaacag tttgaaaaag gaaatgagga gaaaagtatt tgtactgtat aatggaggct     1800

gaccagagca gtttaggaga ttgtaaaggg aggttttgtg aagttctaaa aggttctagt     1860

ttgaaggtcg gccttgtaga ttaaaacgaa ggttacctaa atagaatcta agtggcattt     1920

aaaacagtaa agttgtagag aatagtttga aaatgaggtg tagttttaaa agattgagaa     1980

aagtaggtta agttgacggc cgttataaaa atccttcgac tggcgcatgt acgtttgaag     2040

gcatgagttg gaaacaggga agatggaagt gttaggctag ccgggcgatg gtggcgcacg     2100

cctttaatcc tagcacttgg gaggcagagg caggcggatt tctgagttcg aggccagcct     2160

ggtctacaga gtgagttcca ggacagccag ggctacacag agaaaccctg tcttgaaaaa     2220

acaaaaaggt taggctagta tttggagaaa gaagattaga aaatggaagt gaaagacgaa     2280

gaagacatac aggaaggtga agaaaaagct gttagagaag ataggaaaat agaagacaaa     2340

gcatctttag aagacagaaa aggtacttaa aggcacaggt agtaggaagc cgaagaatag     2400

aagatagaaa gaagcaagat agaaaaacaa aatggaagtt aagacaactt tggatgccag     2460

cattcaagat aggcaaagaa gataagattg aggccaaaag gttggataag atataaagtc     2520

agaaggaaat tatctttaaa gccataagtt caaatttctg atggagcgag cagtttagaa     2580

gagtctttag acagccacat acaagattga agctagcaat caaagctact aggactgaag     2640

taaaaagtta aggcagaatg cctttgaaga gttagaagaa tattaaaagc cttaacttgt     2700

agcttaattt tgcttgatga caaaaggact tttgataaca gtttcaagat tgtcagcatt     2760

ttgcattgga cttgagctga ggtgctttta aaatcctaac gactagcatt ggcagctgac     2820

ccaggtctac acagaagtgc attcagtgaa ctaggaagac aggagcggca gacaggagtc     2880

ccgaagccag tttggtgaag ctaggaagga ctgaggagcc agcagcagca gtgcatggtg     2940

aagatagccc aggaaagagt gcggttcggt ggaggaagct aggaagaagg agccatacgg     3000

atgtggtggt gaagctggga aagggttcca ggatggtgga gcgagagcga gttggtgatg     3060

aagctagctg gcggcttggc ttgtcaactg cgcggaggag gcgagcaggc attgtggaga     3120

ggatagatag cggctcctag accagcatgc cagtgtgcaa gaaaggctgc agggagagca     3180

tgcggtgcgg taacattcct tgaggtcggc aacatggtgg tggttttctg taacttggat     3240

ggtaacttgt ttactttgtc ttaatagtta tgggggagtt gtaggcttct gtgtaaagag     3300

atatatctgg ggctgtatgt aggcctttgc gggtgttgta ggtttttctt tttcagggtt     3360

atgtcctctt gcatcttgtc agaagctttt gagggctgac tgccaaggcc cagaaagaag     3420

aatggtagat ggcaagttgt ctttaaccgc tcagagggga atgaatggta gagccagcac     3480

aacctcccag ttttgtaaga cgttgtagtt tgaacagatg acctaccaca agcctcactc     3540

ctgtgtaggg gaggtaattg ggcaaagtgc ttttggggga atgggggcaa aatatatttt     3600

gagttctttt ccccttaggt ctgtctagaa tcctaaaggc agatgactca agggaaccag     3660

aaaaaaggaa atccactctc aggataagca gagctcgcca ggtttacagt ttgtaggaag     3720

tagaggatgg atgctagctt tcacactgag tgtggaggag ctggccatgg cggaattgct     3780

ggtagtttac tctttccccc tcccttaatg agatttgtaa aatcctaaac acttttactt     3840

gaaatatttg ggagtggtct taacagggag gagtgggtgg gggaaacgtt ttttttctaa     3900

gattttccac agatgctata gttgtgttga cacactgggt tagagaaggc gtgtactgct     3960

atgctgttgg cacgacacct tcagggactg gagctgcctt ttgtccttgg aagagttttc     4020

ccagttgccg ctgaagtcag cacagtgcgg ctttggttca cagtcacctc aggagaacct     4080

caggagcttg gctaggccag aggttgaagt taagttttac agcaccgtga tttaaaatat     4140

ttcattaaag gggaggggta aaacttagtt ggctgtggcc ttgtgtttgg gtgggtgggg     4200

gtgttaggta attgtttagt ttatgatttc agataatcat accagagaac ttaaatattt     4260

ggaaaaacag gaaatctcag ctttcaagtt ggcaagtaac tcccaatcca gtttttgctt     4320

cttttttcct ttttcttttt ttgaggcggg cagctaagga aggttggttc ctctgccggt     4380

ccctcgaaag cgtagggctt gggggttggt ctggtccact gggatgatgt gatgctacag     4440

tggggactct tctgaagctg ttggatgaat atagattgta gtgtgtggtt ctcttttgaa     4500

atttttttca ggtgacttaa tgtatcttaa taactactat aggaacaaag gaagtggctt     4560

taatgaccct gaaggaattt cttctggtga tagcttttat attatcaagt aagagatact     4620

atctcagttt tgtataagca agtctttttc ctagtgtagg agaaatgatt ttccttgtga     4680

ctaaacaaga tgtaaaggta tgcttttttt cttcttgtgc attgtatact tgtgtttatt     4740

tgtaacttat aatttaagaa ttatgataat tcagcctgaa tgtcttttag agggtgggct     4800

tttgttgatg agggagggga aacctttttt tttctgtaga cctttttcag ataacaccat     4860

ctgagtcata accagcctgg cagtgtgatg acgtagatgc agagggagca gctccttggt     4920

gaatgagtga taagtaaagg cagaaaaaat aatgtcatgt ctccatgggg aatgagcatg     4980

agccagagat tgttcctact gatgaaaagc tgcatatgca aaaatttaag caaatgaaag     5040

caaccagtat aaagttatgg caataccttt aaaagttatg gcttatctac caagctttat     5100

ccacaaaagt aaagaattga tgaaaaacag tgaagatcaa atgttcatct caaaactgct     5160

tttacaaaag cagaatagaa atgaagtgaa aatgctgcat taagcctgga gtaaaaagaa     5220

gctgagcttg ttgagatgag tgggatcgag cggctgcgag gcggtgcagt gtgccaatgt     5280

ttcgtttgcc tcagacaggt ttctcttcat aagcagaaga gttgcttcat tccatctcgg     5340

agcaggaaac agcagactgc tgttgacaga taagtgtaac ttggatctgc agtattgcat     5400

gttagggata gataagtgcc ttttttctct ttttccaaaa agacctgtag agctgttgaa     5460

tgtttgcagc tggcccctct taggcagttc agaattttga gtagttttcc catccagcct     5520

cttaaaaatt cctaagcctt gcaccgatgg gctttcatga tgggatagct aataggcttt     5580

tgcatcgtaa acttcaacac aaaagcctac atgattaatg cctactttaa ttacattgct     5640

tacaagatta aggaatcttt atcttgaaga ccccatgaaa gggatcatta tgtgctgaaa     5700

attagatgtt catattgcta aaatttaaat gtgctccaat gtacttgtgc ttaaaatcat     5760

taaattatac aaattaataa aatacttcac tagagaatgt atgtatttag aaggctgtct     5820

ccttatttaa ataaagtctt gtttgttgtc tgtagttagt gtgggcaatt ttggggggat     5880

gttcttctct aatcttttca gaaacttgac ttcgaacact taagtggacc agatcaggat     5940

ttgagccaga agaccgaaat taactttaag gcaggaaaga caaattttat tctccatgca     6000

gtgatgagca tttaataatt gcaggcctgg catagaggcc gtctaactaa ggactaagta     6060

ccttaggcag gtgggagatg atggtcagag taaaaggtaa ctacatattt tgtttccaga     6120

aagtcagggg tctaatttga ccatggctaa acatctaggg taagacactt ttcccccaca     6180

tttccaaata tgcatgttga gtttaaatgc ttacgatcat ctcatccact ttagcctttt     6240

gtcacctcac ttgagccacg agtggggtca ggcatgtggg tttaaagagt tttcctttgc     6300

agagcctcat ttcatccttc atggagctgc tcaggacttt gcatataagc gcttgcctct     6360

gtcttctgtt ctgctagtga gtgtgtgatg tgagaccttg cagtgagttt gtttttcctg     6420

gaatgtggag ggaggggggg atggggctta cttgttctag cttttttttt acagaccaca     6480

cagaatgcag gtgtcttgac ttcaggtcat gtctgttctt tggcaagtaa tatgtgcagt     6540

actgttccaa tctgctgcta ttagaatgca ttgtgacgcg actggagtat gattaaagaa     6600

agttgtgttt ccccaagtgt ttggagtagt ggttgttgga ggaaaagcca tgagtaacag     6660

gctgagtgtt gaggaaatgg ctctctgcag ctttaagtaa cccgtgtttg tgattggagc     6720

cgagtccctt tgctgtgctg ccttaggtaa atgtttttgt tcatttctgg tgaggggggt     6780

tgggagcact gaagccttta gtctcttcca gattcaactt aaaatctgac aagaaataaa     6840

tcagacaagc aacattcttg aagaaatttt aactggcaag tggaaatgtt ttgaacagtt     6900

ccgtggtctt tagtgcatta tctttgtgta ggtgttctct ctcccctccc ttggtcttaa     6960

ttcttacatg caggaacatt gacaacagca gacatctatc tattcaaggg gccagagaat     7020

ccagacccag taaggaaaaa tagcccattt actttaaatc gataagtgaa gcagacatgc     7080

cattttcagt gtggggattg ggaagcccta gttctttcag atgtacttca gactgtagaa     7140

ggagcttcca gttgaattga aattcaccag tggacaaaat gaggacaaca ggtgaacgag     7200

ccttttcttg tttaagatta gctactggta atctagtgtt gaatcctctc cagcttcatg     7260

ctggagcagc tagcatgtga tgtaatgttg gccttggggt ggaggggtga ggtgggcgct     7320

aagccttttt ttaagatttt tcaggtaccc ctcactaaag gcactgaagg cttaatgtag     7380

gacagcggag ccttcctgtg tggcaagaat caagcaagca gtattgtatc gagaccaaag     7440

tggtatcatg gtcggttttg attagcagtg gggactaccc taccgtaaca ccttgttgga     7500

attgaagcat ccaaagaaaa tacttgagag gccctgggct tgttttaaca tctggaaaaa     7560

aggctgtttt tatagcagcg gttaccagcc caaacctcaa gttgtgcttg caggggaggg     7620

aaaaggggga aagcgggcaa ccagtttccc cagcttttcc agaatcctgt tacaaggtct     7680

ccccacaagt gatttctctg ccacatcgcc accatgggcc tttggcctaa tcacagaccc     7740

ttcacccctc accttgatgc agccagtagc tggatccttg aggtcacgtt gcatatcggt     7800

ttcaaggtaa ccatggtgcc aaggtcctgt gggttgcacc agaaaaggcc atcaattttc     7860

cccttgcctg taatttaaca ttaaaaccat agctaagatg ttttatacat agcacctatg     7920

cagagtaaac aaaccagtat gggtatagta tgtttgatac cagtgctggg tgggaatgta     7980

ggaagtcgga tgaaaagcaa gcctttgtag gaagttgttg gggtgggatt gcaaaaattc     8040

tctgctaaga ctttttcagg tggacataac agacttggcc aagctagcat cttagtggaa     8100

gcagattcgt cagtagggtt gtaaaggttt ttcttttcct gagaaaacaa ccttttgttt     8160

tctcaggttt tgctttttgg cctttcccta gctttaaaaa aaaaaaagca aaagacgctg     8220

gtggctggca ctcctggttt ccaggacggg gttcaagtcc ctgcggtgtc tttgcttgac     8280

tcttatatca tgaggccatt acatttttct tggagggttc taaaggctct gggtatggta     8340

gctgatatca ctggaacact ccccagcctc agtgttgaac tcttgataat taactgcatt     8400

gtctttcagg ttatgcccaa ttcgtcttat tacctctgag tcgacacacc tcctactatt     8460

tattgaatac tttgatttta tgaaataaaa actaaatatc tctcattgtg tgcttctttg     8520

tgcataaaac acaggcttat tttaagccta aagagaccaa atgtctgatc tacctcagct     8580

tctccgatta gtgaggcctt ccctgtttcc ttgggctgca tggctctttc atgcagatgg     8640

ctctaaagtt gggcttgggt cctaggtggc cactcttgca cctcaggaac acaaggcctt     8700

tccctgctgt tcaggctctc ctccctgaga aaacattctg gattgtctat gaggaagttg     8760

ggaaaagatg gtgtcgaaaa gaggtggtgt gcattgctcc tctgttccta acactggatg     8820

gaagactagt tttcatgtag tttagggaaa tagttataca tggtctaaag gcccaaaaac     8880

attcccagag tgtatgcaat actgtgtgta agtgtgcact gcgtgtgttt ggaggtcaga     8940

acttctctga ggttctagag atgaagcaag tcctcagcca tggcccaaga atgggaagga     9000

actgggtcct gctgtaccac ttcccattcc ttaaggaaca gtttggcccg gtgtggtgca     9060

agcatggtcg gtcactgaaa aaagaaaacc cacttaggtt tcacaggctt gaagagctgc     9120

atgtcatcca gcaaattact ggctgctgta aggacaggcc cctaggtccc agtcccaggt     9180

gcccttcctg ccactcaatc aagccttaca ccctgggcaa aaacatcctg cgttgaaggt     9240

tcagctccca gggctggaaa cttgtgctgg catctacccc agttcaaagg ggctcagcac     9300

attgacaact aaaactaagc cctcaggtga gcaaaatggt ctccttaagg caatcatggt     9360

cattggtgtt cctgcagtaa aggacagcat cacagctgat gtctgtgtac tggctagttt     9420

tgtatcaact tgacacagct ggaattatca cagagaaagc ttcagttggg gaagtgcctc     9480

caagagatcc tccacgagat cctgctctaa ggcattttct caattagtga tcaaggggga     9540

aagacccctt gtgtgtggga ccatctctgg gctggtagtc ttggttcagt tctataagag     9600

agcaggctga gcaagccagg ggaagcaagc cagtaaagaa catccctcca tggcctctgc     9660

atcagctcct gcttcctgac ctgcttgagt tccagtcctg acttccttgg tgatgaacag     9720

cagtatggaa gtgtaagccg aataaaccct gtcctcccca acttgcttct tggtcatgtt     9780

tgtgcaggaa tagaaaccct gactaagaca gtctgagacc tgacagatct gtgctaaagt     9840

ctggtaccaa ctgagctaga ccctgccaca cacctcagta atggcccatt ctgaattcac     9900

ccagagctga ggctttgccg aggtgaggca caaagacttc actggagagc aggagatatg     9960

aacagaggtt ggggctcaca cttcctgatt gggggccagg a                        10001


