                         SEQUENCE LISTING

<110>  The University of Chicago
 
<120>  Treatment of Liver Fibrosis with Genetically-engineered 
       Macrophages

<130>  ARCD.P0669WO

<150>  62/598,894
<151>  2017-12-14

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  3537
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(3537)

<400>  1
atg gtc ccc agg cgt cct gct agc cta gag gtc act gta gcc tgc atc         48
Met Val Pro Arg Arg Pro Ala Ser Leu Glu Val Thr Val Ala Cys Ile           
1               5                   10                  15                

tgg ctt ctc acc gtt atc cta ggc gtc tgc atc tcc ttc aac gtt gat         96
Trp Leu Leu Thr Val Ile Leu Gly Val Cys Ile Ser Phe Asn Val Asp           
            20                  25                  30                    

gtc aaa aac tcc atg agc ttc agt ggt cca gtg gag gac atg ttt gga        144
Val Lys Asn Ser Met Ser Phe Ser Gly Pro Val Glu Asp Met Phe Gly           
        35                  40                  45                        

tac acc gtt caa cag tat gaa aac gaa gaa ggc aaa tgg gtt ctt att        192
Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile           
    50                  55                  60                            

ggt tct cct tta gtt ggc caa ccc aaa gca aga act gga gat gtc tat        240
Gly Ser Pro Leu Val Gly Gln Pro Lys Ala Arg Thr Gly Asp Val Tyr           
65                  70                  75                  80            

aag tgt cca gtt ggg aga gag aga tca atg cct tgt gtg aag ttg gat        288
Lys Cys Pro Val Gly Arg Glu Arg Ser Met Pro Cys Val Lys Leu Asp           
                85                  90                  95                

tta cca gtt aac aca tcg att cct aat gtc aca gaa ata aag gaa aac        336
Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Ile Lys Glu Asn           
            100                 105                 110                   

atg aca ttt gga tca act tta gtc acc aat ccg aag gga gga ttt ctg        384
Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Lys Gly Gly Phe Leu           
        115                 120                 125                       

gca tgt ggg ccc ttg tat gcc tat aga tgt gga cat ttg cat tat acg        432
Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr           
    130                 135                 140                           

act ggc ata tgt tct gat gtc agc cct aca ttt caa gtt gtg aac tcg        480
Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser           
145                 150                 155                 160           

ttc gcc cct gta caa gaa tgt agc aca cag ctt gac ata gtc atc gtc        528
Phe Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val           
                165                 170                 175               

cta gat ggc tcc aac agc atc tac ccc tgg gaa agt gtc act gcc ttt        576
Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Glu Ser Val Thr Ala Phe           
            180                 185                 190                   

tta aac gac ctt ctt aag agg atg gac att ggc ccc aaa cag aca cag        624
Leu Asn Asp Leu Leu Lys Arg Met Asp Ile Gly Pro Lys Gln Thr Gln           
        195                 200                 205                       

gtt gga att gta caa tat gga gca aat gta aca cat gag ttc aac ctc        672
Val Gly Ile Val Gln Tyr Gly Ala Asn Val Thr His Glu Phe Asn Leu           
    210                 215                 220                           

aat aag tat tca tcc aca gaa gag gtc ctg gtg gca gca aac aaa ata        720
Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Asn Lys Ile           
225                 230                 235                 240           

ggc cgc agg ggt ggt ctc cag acg atg aca gcc ctt gga ata gac aca        768
Gly Arg Arg Gly Gly Leu Gln Thr Met Thr Ala Leu Gly Ile Asp Thr           
                245                 250                 255               

gcc agg aaa gag gca ttc act gaa gct cgg ggg gcc aga agg gga gtg        816
Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val           
            260                 265                 270                   

aaa aaa gtc atg gtt att gtg act gat gga gaa tcg cat gac aac tat        864
Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn Tyr           
        275                 280                 285                       

cgc ctg aaa cag gtc atc caa gac tgt gag gat gaa aac att cag cga        912
Arg Leu Lys Gln Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg           
    290                 295                 300                           

ttt tcc ata gct atc ctt ggc cac tat aac agg ggg aac tta agc acc        960
Phe Ser Ile Ala Ile Leu Gly His Tyr Asn Arg Gly Asn Leu Ser Thr           
305                 310                 315                 320           

gaa aaa ttt gtg gag gag ata aaa tca atc gca agt gag ccc acc gaa       1008
Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu           
                325                 330                 335               

aag cac ttc ttc aac gtc tca gat gag ttg gcc ctg gtc act att gtt       1056
Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val           
            340                 345                 350                   

aaa gct ctg gga gaa agg ata ttt gct ttg gaa gct aca gct gac cag       1104
Lys Ala Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln           
        355                 360                 365                       

tca gca gct tcg ttt gaa atg gag atg tct cag acc ggc ttc agt gct       1152
Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala           
    370                 375                 380                           

cat tat tca cag gac tgg gtc atg ctt gga gct gtt gga gcc tat gac       1200
His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp           
385                 390                 395                 400           

tgg aac gga act gtg gtc atg cag aag gct aac cag att gtc atc cct       1248
Trp Asn Gly Thr Val Val Met Gln Lys Ala Asn Gln Ile Val Ile Pro           
                405                 410                 415               

cat aac acc acc ttt caa act gag ccc acc aag atg aac gag cct ctt       1296
His Asn Thr Thr Phe Gln Thr Glu Pro Thr Lys Met Asn Glu Pro Leu           
            420                 425                 430                   

gct tct tac ttg ggt tac aca gtg aac tct gcc acc atc ccg gga gat       1344
Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ile Pro Gly Asp           
        435                 440                 445                       

gtg ctc tat atc gct ggg cag cct cgg tac aat cac acc ggc cag gtc       1392
Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln Val           
    450                 455                 460                           

gtc atc tac aag atg gag gat ggg gac gtc aac att ctg cag aca ctc       1440
Val Ile Tyr Lys Met Glu Asp Gly Asp Val Asn Ile Leu Gln Thr Leu           
465                 470                 475                 480           

agt gga gag cag atc gga tcc tac ttt ggt agc gtc tta acc aca att       1488
Ser Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Thr Thr Ile           
                485                 490                 495               

gac atc gac aaa gat tct tac act gat ctg ctt ctc gtc ggg gct ccc       1536
Asp Ile Asp Lys Asp Ser Tyr Thr Asp Leu Leu Leu Val Gly Ala Pro           
            500                 505                 510                   

atg tat atg ggg aca gag aaa gag gaa cag ggc aag gtg tac gtg tac       1584
Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val Tyr           
        515                 520                 525                       

gct gtg aat cag acg agg ttt gaa tat caa atg agc ctg gaa cca att       1632
Ala Val Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro Ile           
    530                 535                 540                           

aag cag acc tgc tgt tca tcc ctg aag gat aat tca tgc aca aaa gaa       1680
Lys Gln Thr Cys Cys Ser Ser Leu Lys Asp Asn Ser Cys Thr Lys Glu           
545                 550                 555                 560           

aac aag aat gag ccc tgt ggg gcc cgt ttt gga aca gca gtt gct gct       1728
Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Val Ala Ala           
                565                 570                 575               

gta aaa gac ctc aac gtg gat ggc ttt aat gac gtc gtg att gga gct       1776
Val Lys Asp Leu Asn Val Asp Gly Phe Asn Asp Val Val Ile Gly Ala           
            580                 585                 590                   

ccc ctg gaa gac gac cac gca gga gct gtg tac att tat cat ggc agt       1824
Pro Leu Glu Asp Asp His Ala Gly Ala Val Tyr Ile Tyr His Gly Ser           
        595                 600                 605                       

ggc aag acc ata agg aaa gag tat gcg caa cgc att ccc tca ggt ggg       1872
Gly Lys Thr Ile Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly Gly           
    610                 615                 620                           

gat ggg aag acg ctg aaa ttt ttt ggc cag tct atc cac gga gag atg       1920
Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu Met           
625                 630                 635                 640           

gat tta aat ggc gat ggt ctg act gac gtg acc att gga ggc ctt gga       1968
Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu Gly           
                645                 650                 655               

gga gct gcc ctc ttc tgg gcc aga gat gtg gct gta gtt aaa gtg acc       2016
Gly Ala Ala Leu Phe Trp Ala Arg Asp Val Ala Val Val Lys Val Thr           
            660                 665                 670                   

atg aat ttt gaa ccc aac aaa gtg aat att caa aag aaa aac tgc cgt       2064
Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys Arg           
        675                 680                 685                       

gtg gag ggc aaa gaa aca gta tgc ata aat gct aca atg tgt ttt cat       2112
Val Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Met Cys Phe His           
    690                 695                 700                           

gtg aaa ttg aag tct aaa gaa gac tca gtt tac gag gct gat ctg cag       2160
Val Lys Leu Lys Ser Lys Glu Asp Ser Val Tyr Glu Ala Asp Leu Gln           
705                 710                 715                 720           

tac cgt gtc acc ctt gat tcg ctg agg cag ata tca cgg agc ttt ttt       2208
Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe Phe           
                725                 730                 735               

tct gga act cag gaa agg agg att caa aga aac ctc acc gtt cga gaa       2256
Ser Gly Thr Gln Glu Arg Arg Ile Gln Arg Asn Leu Thr Val Arg Glu           
            740                 745                 750                   

tcc gaa tgc atc agg cac tcc ttc tac atg ttg gat aag cac gac ttt       2304
Ser Glu Cys Ile Arg His Ser Phe Tyr Met Leu Asp Lys His Asp Phe           
        755                 760                 765                       

cag gac tcc gtg aga gtg act ttg gat ttt aac ctc act gat cca gaa       2352
Gln Asp Ser Val Arg Val Thr Leu Asp Phe Asn Leu Thr Asp Pro Glu           
    770                 775                 780                           

aat ggg ccc gtg ctc gat gac gct ctg cca aac tca gtc cat gga cat       2400
Asn Gly Pro Val Leu Asp Asp Ala Leu Pro Asn Ser Val His Gly His           
785                 790                 795                 800           

att cct ttt gcc aaa gac tgt ggg aac aag gaa aga tgc gtt tca gac       2448
Ile Pro Phe Ala Lys Asp Cys Gly Asn Lys Glu Arg Cys Val Ser Asp           
                805                 810                 815               

ctc acc ctg gat gtg tcc aca aca gaa aag aac ctg ctg att gtc aga       2496
Leu Thr Leu Asp Val Ser Thr Thr Glu Lys Asn Leu Leu Ile Val Arg           
            820                 825                 830                   

tcc cag aat gac aag ttc aat gtc agc ctc acc gtc aaa aac aag gga       2544
Ser Gln Asn Asp Lys Phe Asn Val Ser Leu Thr Val Lys Asn Lys Gly           
        835                 840                 845                       

gac agt gcg tac aac acc cgg aca gtg gtt cag tat tct cca aat ctg       2592
Asp Ser Ala Tyr Asn Thr Arg Thr Val Val Gln Tyr Ser Pro Asn Leu           
    850                 855                 860                           

att ttt tca gga att gag gag atc caa aaa gat agc tgc gaa tcc aat       2640
Ile Phe Ser Gly Ile Glu Glu Ile Gln Lys Asp Ser Cys Glu Ser Asn           
865                 870                 875                 880           

caa aat atc acg tgt aga gtt gga tat cct ttc ctg agg aca gga gac       2688
Gln Asn Ile Thr Cys Arg Val Gly Tyr Pro Phe Leu Arg Thr Gly Asp           
                885                 890                 895               

gtg gtt aac ttc aaa ata ata ttc cag ttt aat aca tca cat ctc tca       2736
Val Val Asn Phe Lys Ile Ile Phe Gln Phe Asn Thr Ser His Leu Ser           
            900                 905                 910                   

gaa aat gca att att cat tta agt gca aca agt gac agt gaa gag ccc       2784
Glu Asn Ala Ile Ile His Leu Ser Ala Thr Ser Asp Ser Glu Glu Pro           
        915                 920                 925                       

ctg gaa tct ctt tac gat aat gaa gta aat att tcc atc ccc gta aaa       2832
Leu Glu Ser Leu Tyr Asp Asn Glu Val Asn Ile Ser Ile Pro Val Lys           
    930                 935                 940                           

tat gaa gtc gga ctg cag ttt tac agt tct gcg agt gaa cac cac att       2880
Tyr Glu Val Gly Leu Gln Phe Tyr Ser Ser Ala Ser Glu His His Ile           
945                 950                 955                 960           

tca gtt gct gcc aat gag act gtt cct gag ctg att aat tcc acc aag       2928
Ser Val Ala Ala Asn Glu Thr Val Pro Glu Leu Ile Asn Ser Thr Lys           
                965                 970                 975               

gac att ggg gat gaa att aat gtc ttc tac acg att aga aaa aga ggg       2976
Asp Ile Gly Asp Glu Ile Asn Val Phe Tyr Thr Ile Arg Lys Arg Gly           
            980                 985                 990                   

cat ttc cca atg cca gaa ctt cgg  ctg gca att tca ttt  ccc aat ctg     3024
His Phe Pro Met Pro Glu Leu Arg  Leu Ala Ile Ser Phe  Pro Asn Leu         
        995                 1000                 1005                     

acg tca  gat ggc tat cct gta  ctg tac cca act gga  tgg tca tct        3069
Thr Ser  Asp Gly Tyr Pro Val  Leu Tyr Pro Thr Gly  Trp Ser Ser            
    1010                 1015                 1020                        

tct gat  aat gta aac tgc aga  cct cga agc ctt gag  gac cct ttg        3114
Ser Asp  Asn Val Asn Cys Arg  Pro Arg Ser Leu Glu  Asp Pro Leu            
    1025                 1030                 1035                        

ggt atc  aac tct ggg aag aaa  atg aca ata tca aag  tct gag gtt        3159
Gly Ile  Asn Ser Gly Lys Lys  Met Thr Ile Ser Lys  Ser Glu Val            
    1040                 1045                 1050                        

ctc aaa  aga ggc aca atc cag  gac tgc agt acc tgc  aag att gct        3204
Leu Lys  Arg Gly Thr Ile Gln  Asp Cys Ser Thr Cys  Lys Ile Ala            
    1055                 1060                 1065                        

acc atc  acg tgt cat ctc ctt  ccc tcg gat gtg agt  caa gtg aat        3249
Thr Ile  Thr Cys His Leu Leu  Pro Ser Asp Val Ser  Gln Val Asn            
    1070                 1075                 1080                        

gtc tca  ctc atc ttg tgg aaa  cca act ttc ata aaa  gca cat ttt        3294
Val Ser  Leu Ile Leu Trp Lys  Pro Thr Phe Ile Lys  Ala His Phe            
    1085                 1090                 1095                        

tcc agc  tta aat ctt acc ata  cgg gga gaa ctt cag  agt gaa aac        3339
Ser Ser  Leu Asn Leu Thr Ile  Arg Gly Glu Leu Gln  Ser Glu Asn            
    1100                 1105                 1110                        

tca tcg  ctg act tta agc agc  agc aac cgg aaa cga  gag ctg gct        3384
Ser Ser  Leu Thr Leu Ser Ser  Ser Asn Arg Lys Arg  Glu Leu Ala            
    1115                 1120                 1125                        

att cag  ata tcc aaa gac ggg  ctc cca ggc cga gtg  ccg ctg tgg        3429
Ile Gln  Ile Ser Lys Asp Gly  Leu Pro Gly Arg Val  Pro Leu Trp            
    1130                 1135                 1140                        

gtt atc  ctc ctg agc gcc ttt  gcg gga ctc ctg ctg  tta atg ctg        3474
Val Ile  Leu Leu Ser Ala Phe  Ala Gly Leu Leu Leu  Leu Met Leu            
    1145                 1150                 1155                        

ctt ata  tta gct ctg tgg aag  att gga ttc ttc aaa  agg cca cta        3519
Leu Ile  Leu Ala Leu Trp Lys  Ile Gly Phe Phe Lys  Arg Pro Leu            
    1160                 1165                 1170                        

aag aag  aaa atg gag aaa                                              3537
Lys Lys  Lys Met Glu Lys                                                  
    1175                                                                  


<210>  2
<211>  1179
<212>  PRT
<213>  Mus musculus

<400>  2

Met Val Pro Arg Arg Pro Ala Ser Leu Glu Val Thr Val Ala Cys Ile 
1               5                   10                  15      


Trp Leu Leu Thr Val Ile Leu Gly Val Cys Ile Ser Phe Asn Val Asp 
            20                  25                  30          


Val Lys Asn Ser Met Ser Phe Ser Gly Pro Val Glu Asp Met Phe Gly 
        35                  40                  45              


Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile 
    50                  55                  60                  


Gly Ser Pro Leu Val Gly Gln Pro Lys Ala Arg Thr Gly Asp Val Tyr 
65                  70                  75                  80  


Lys Cys Pro Val Gly Arg Glu Arg Ser Met Pro Cys Val Lys Leu Asp 
                85                  90                  95      


Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Ile Lys Glu Asn 
            100                 105                 110         


Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Lys Gly Gly Phe Leu 
        115                 120                 125             


Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr 
    130                 135                 140                 


Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser 
145                 150                 155                 160 


Phe Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val 
                165                 170                 175     


Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Glu Ser Val Thr Ala Phe 
            180                 185                 190         


Leu Asn Asp Leu Leu Lys Arg Met Asp Ile Gly Pro Lys Gln Thr Gln 
        195                 200                 205             


Val Gly Ile Val Gln Tyr Gly Ala Asn Val Thr His Glu Phe Asn Leu 
    210                 215                 220                 


Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Asn Lys Ile 
225                 230                 235                 240 


Gly Arg Arg Gly Gly Leu Gln Thr Met Thr Ala Leu Gly Ile Asp Thr 
                245                 250                 255     


Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val 
            260                 265                 270         


Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn Tyr 
        275                 280                 285             


Arg Leu Lys Gln Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg 
    290                 295                 300                 


Phe Ser Ile Ala Ile Leu Gly His Tyr Asn Arg Gly Asn Leu Ser Thr 
305                 310                 315                 320 


Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu 
                325                 330                 335     


Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val 
            340                 345                 350         


Lys Ala Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln 
        355                 360                 365             


Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala 
    370                 375                 380                 


His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp 
385                 390                 395                 400 


Trp Asn Gly Thr Val Val Met Gln Lys Ala Asn Gln Ile Val Ile Pro 
                405                 410                 415     


His Asn Thr Thr Phe Gln Thr Glu Pro Thr Lys Met Asn Glu Pro Leu 
            420                 425                 430         


Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ile Pro Gly Asp 
        435                 440                 445             


Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln Val 
    450                 455                 460                 


Val Ile Tyr Lys Met Glu Asp Gly Asp Val Asn Ile Leu Gln Thr Leu 
465                 470                 475                 480 


Ser Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Val Leu Thr Thr Ile 
                485                 490                 495     


Asp Ile Asp Lys Asp Ser Tyr Thr Asp Leu Leu Leu Val Gly Ala Pro 
            500                 505                 510         


Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val Tyr 
        515                 520                 525             


Ala Val Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro Ile 
    530                 535                 540                 


Lys Gln Thr Cys Cys Ser Ser Leu Lys Asp Asn Ser Cys Thr Lys Glu 
545                 550                 555                 560 


Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Val Ala Ala 
                565                 570                 575     


Val Lys Asp Leu Asn Val Asp Gly Phe Asn Asp Val Val Ile Gly Ala 
            580                 585                 590         


Pro Leu Glu Asp Asp His Ala Gly Ala Val Tyr Ile Tyr His Gly Ser 
        595                 600                 605             


Gly Lys Thr Ile Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly Gly 
    610                 615                 620                 


Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu Met 
625                 630                 635                 640 


Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu Gly 
                645                 650                 655     


Gly Ala Ala Leu Phe Trp Ala Arg Asp Val Ala Val Val Lys Val Thr 
            660                 665                 670         


Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys Arg 
        675                 680                 685             


Val Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Met Cys Phe His 
    690                 695                 700                 


Val Lys Leu Lys Ser Lys Glu Asp Ser Val Tyr Glu Ala Asp Leu Gln 
705                 710                 715                 720 


Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe Phe 
                725                 730                 735     


Ser Gly Thr Gln Glu Arg Arg Ile Gln Arg Asn Leu Thr Val Arg Glu 
            740                 745                 750         


Ser Glu Cys Ile Arg His Ser Phe Tyr Met Leu Asp Lys His Asp Phe 
        755                 760                 765             


Gln Asp Ser Val Arg Val Thr Leu Asp Phe Asn Leu Thr Asp Pro Glu 
    770                 775                 780                 


Asn Gly Pro Val Leu Asp Asp Ala Leu Pro Asn Ser Val His Gly His 
785                 790                 795                 800 


Ile Pro Phe Ala Lys Asp Cys Gly Asn Lys Glu Arg Cys Val Ser Asp 
                805                 810                 815     


Leu Thr Leu Asp Val Ser Thr Thr Glu Lys Asn Leu Leu Ile Val Arg 
            820                 825                 830         


Ser Gln Asn Asp Lys Phe Asn Val Ser Leu Thr Val Lys Asn Lys Gly 
        835                 840                 845             


Asp Ser Ala Tyr Asn Thr Arg Thr Val Val Gln Tyr Ser Pro Asn Leu 
    850                 855                 860                 


Ile Phe Ser Gly Ile Glu Glu Ile Gln Lys Asp Ser Cys Glu Ser Asn 
865                 870                 875                 880 


Gln Asn Ile Thr Cys Arg Val Gly Tyr Pro Phe Leu Arg Thr Gly Asp 
                885                 890                 895     


Val Val Asn Phe Lys Ile Ile Phe Gln Phe Asn Thr Ser His Leu Ser 
            900                 905                 910         


Glu Asn Ala Ile Ile His Leu Ser Ala Thr Ser Asp Ser Glu Glu Pro 
        915                 920                 925             


Leu Glu Ser Leu Tyr Asp Asn Glu Val Asn Ile Ser Ile Pro Val Lys 
    930                 935                 940                 


Tyr Glu Val Gly Leu Gln Phe Tyr Ser Ser Ala Ser Glu His His Ile 
945                 950                 955                 960 


Ser Val Ala Ala Asn Glu Thr Val Pro Glu Leu Ile Asn Ser Thr Lys 
                965                 970                 975     


Asp Ile Gly Asp Glu Ile Asn Val Phe Tyr Thr Ile Arg Lys Arg Gly 
            980                 985                 990         


His Phe Pro Met Pro Glu Leu Arg  Leu Ala Ile Ser Phe  Pro Asn Leu 
        995                 1000                 1005             


Thr Ser  Asp Gly Tyr Pro Val  Leu Tyr Pro Thr Gly  Trp Ser Ser 
    1010                 1015                 1020             


Ser Asp  Asn Val Asn Cys Arg  Pro Arg Ser Leu Glu  Asp Pro Leu 
    1025                 1030                 1035             


Gly Ile  Asn Ser Gly Lys Lys  Met Thr Ile Ser Lys  Ser Glu Val 
    1040                 1045                 1050             


Leu Lys  Arg Gly Thr Ile Gln  Asp Cys Ser Thr Cys  Lys Ile Ala 
    1055                 1060                 1065             


Thr Ile  Thr Cys His Leu Leu  Pro Ser Asp Val Ser  Gln Val Asn 
    1070                 1075                 1080             


Val Ser  Leu Ile Leu Trp Lys  Pro Thr Phe Ile Lys  Ala His Phe 
    1085                 1090                 1095             


Ser Ser  Leu Asn Leu Thr Ile  Arg Gly Glu Leu Gln  Ser Glu Asn 
    1100                 1105                 1110             


Ser Ser  Leu Thr Leu Ser Ser  Ser Asn Arg Lys Arg  Glu Leu Ala 
    1115                 1120                 1125             


Ile Gln  Ile Ser Lys Asp Gly  Leu Pro Gly Arg Val  Pro Leu Trp 
    1130                 1135                 1140             


Val Ile  Leu Leu Ser Ala Phe  Ala Gly Leu Leu Leu  Leu Met Leu 
    1145                 1150                 1155             


Leu Ile  Leu Ala Leu Trp Lys  Ile Gly Phe Phe Lys  Arg Pro Leu 
    1160                 1165                 1170             


Lys Lys  Lys Met Glu Lys 
    1175                 


<210>  3
<211>  3537
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(3537)

<400>  3
atg gcc cct cgg ccc cgc gcc cgc cca ggg gtc gct gtc gcc tgc tgc         48
Met Ala Pro Arg Pro Arg Ala Arg Pro Gly Val Ala Val Ala Cys Cys           
1               5                   10                  15                

tgg ctc ctc act gtt gtt cta cgc tgc tgc gta tca ttc aat gtt gat         96
Trp Leu Leu Thr Val Val Leu Arg Cys Cys Val Ser Phe Asn Val Asp           
            20                  25                  30                    

gtg aaa aat tca atg act ttc agc ggc ccg gtg gaa gac atg ttt gga        144
Val Lys Asn Ser Met Thr Phe Ser Gly Pro Val Glu Asp Met Phe Gly           
        35                  40                  45                        

tat act gtt caa caa tat gaa aat gaa gaa gga aaa tgg gtg ctt att        192
Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile           
    50                  55                  60                            

ggt tct ccg tta gtt ggc caa ccc aaa aac aga act gga gat gtc tat        240
Gly Ser Pro Leu Val Gly Gln Pro Lys Asn Arg Thr Gly Asp Val Tyr           
65                  70                  75                  80            

aag tgt cca gtt ggg aga ggt gaa tca tta cct tgt gta aag ttg gat        288
Lys Cys Pro Val Gly Arg Gly Glu Ser Leu Pro Cys Val Lys Leu Asp           
                85                  90                  95                

cta cca gtt aat aca tca att ccc aat gtc aca gaa gta aag gag aac        336
Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Val Lys Glu Asn           
            100                 105                 110                   

atg aca ttt gga tca act tta gtc acc aac cca aat gga gga ttt ctg        384
Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Asn Gly Gly Phe Leu           
        115                 120                 125                       

gct tgt ggg ccc tta tat gcc tat aga tgt gga cat ttg cat tac aca        432
Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr           
    130                 135                 140                           

act gga atc tgt tct gac gtc agc ccc aca ttt caa gtc gtg aat tcc        480
Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser           
145                 150                 155                 160           

att gcc cct gta caa gaa tgc agc act caa ctg gac ata gtc ata gtg        528
Ile Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val           
                165                 170                 175               

ctg gat ggt tcc aac agt att tac cca tgg gac agt gtt aca gct ttt        576
Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Asp Ser Val Thr Ala Phe           
            180                 185                 190                   

tta aat gac ctt ctt gaa aga atg gat att ggt cct aaa cag aca cag        624
Leu Asn Asp Leu Leu Glu Arg Met Asp Ile Gly Pro Lys Gln Thr Gln           
        195                 200                 205                       

gtt gga att gta cag tat gga gaa aac gtg acc cat gag ttc aac ctc        672
Val Gly Ile Val Gln Tyr Gly Glu Asn Val Thr His Glu Phe Asn Leu           
    210                 215                 220                           

aat aag tat tct tcc acc gaa gag gta ctt gtt gca gca aag aaa ata        720
Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Lys Lys Ile           
225                 230                 235                 240           

gtc cag aga ggt ggc cgc cag act atg aca gct ctt gga ata gac aca        768
Val Gln Arg Gly Gly Arg Gln Thr Met Thr Ala Leu Gly Ile Asp Thr           
                245                 250                 255               

gca aga aag gag gca ttc acg gaa gcc cgg ggt gcc cga aga gga gtt        816
Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val           
            260                 265                 270                   

aaa aaa gtc atg gtt att gtg aca gat gga gag tct cat gac aat cat        864
Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn His           
        275                 280                 285                       

cga ctg aag aag gtc atc caa gac tgt gaa gat gaa aac att caa cgg        912
Arg Leu Lys Lys Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg           
    290                 295                 300                           

ttt tcc ata gct att ctt ggc agc tat aac cga gga aat tta agc act        960
Phe Ser Ile Ala Ile Leu Gly Ser Tyr Asn Arg Gly Asn Leu Ser Thr           
305                 310                 315                 320           

gaa aaa ttt gtg gag gaa ata aaa tca att gca agt gaa ccc act gaa       1008
Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu           
                325                 330                 335               

aag cat ttc ttc aat gtc tct gat gaa ttg gct cta gtc acc att gtt       1056
Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val           
            340                 345                 350                   

aaa act ctg gga gaa aga ata ttt gcc ctg gaa gcc aca gct gac cag       1104
Lys Thr Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln           
        355                 360                 365                       

tca gca gct tca ttt gaa atg gaa atg tct cag act ggc ttc agt gct       1152
Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala           
    370                 375                 380                           

cat tat tca cag gac tgg gtc atg ctt gga gca gta gga gcc tat gat       1200
His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp           
385                 390                 395                 400           

tgg aat gga aca gtt gtc atg cag aag gct agt caa atc ata atc cct       1248
Trp Asn Gly Thr Val Val Met Gln Lys Ala Ser Gln Ile Ile Ile Pro           
                405                 410                 415               

cga aac aca acc ttt aat gtt gag tct acc aaa aag aat gaa ccg ctt       1296
Arg Asn Thr Thr Phe Asn Val Glu Ser Thr Lys Lys Asn Glu Pro Leu           
            420                 425                 430                   

gct tct tat tta ggt tac act gta aac tct gct act gct tct tct gga       1344
Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ala Ser Ser Gly           
        435                 440                 445                       

gat gtg ctc tat att gct gga cag cct cgg tac aat cat aca ggc cag       1392
Asp Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln           
    450                 455                 460                           

gtc att atc tac agg atg gaa gat gga aac atc aaa att ctc cag acg       1440
Val Ile Ile Tyr Arg Met Glu Asp Gly Asn Ile Lys Ile Leu Gln Thr           
465                 470                 475                 480           

ctc agt gga gaa cag att ggt tcc tac ttt ggc agt att tta aca aca       1488
Leu Ser Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Ile Leu Thr Thr           
                485                 490                 495               

act gac att gac aag gat tct aat act gac att ctt cta gtc gga gcc       1536
Thr Asp Ile Asp Lys Asp Ser Asn Thr Asp Ile Leu Leu Val Gly Ala           
            500                 505                 510                   

cct atg tac atg gga aca gag aag gag gag caa gga aaa gtg tat gtg       1584
Pro Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val           
        515                 520                 525                       

tat gct ctc aat cag aca agg ttt gaa tat caa atg agc ctg gaa cct       1632
Tyr Ala Leu Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro           
    530                 535                 540                           

att aag cag acg tgc tgt tca tct cgg cag cac aat tca tgc aca aca       1680
Ile Lys Gln Thr Cys Cys Ser Ser Arg Gln His Asn Ser Cys Thr Thr           
545                 550                 555                 560           

gaa aac aaa aat gag cca tgc ggg gct cgt ttt gga act gca att gct       1728
Glu Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Ile Ala           
                565                 570                 575               

gct gta aaa gac ctc aat ctt gat gga ttt aat gac atc gtg ata gga       1776
Ala Val Lys Asp Leu Asn Leu Asp Gly Phe Asn Asp Ile Val Ile Gly           
            580                 585                 590                   

gct ccg ctg gaa gat gat cac ggg gga gct gtg tac att tat cat gga       1824
Ala Pro Leu Glu Asp Asp His Gly Gly Ala Val Tyr Ile Tyr His Gly           
        595                 600                 605                       

agt ggc aag act ata agg aaa gag tat gca caa cgt att cca tca ggt       1872
Ser Gly Lys Thr Ile Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly           
    610                 615                 620                           

ggg gat ggt aag aca ctg aaa ttt ttt ggc cag tct atc cac gga gaa       1920
Gly Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu           
625                 630                 635                 640           

atg gat tta aat ggt gac ggt ctg aca gat gtg act att ggg ggc ctt       1968
Met Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu           
                645                 650                 655               

ggt ggt gct gcc ctc ttc tgg tcc cga gat gtg gcc gta gtt aaa gtg       2016
Gly Gly Ala Ala Leu Phe Trp Ser Arg Asp Val Ala Val Val Lys Val           
            660                 665                 670                   

acc atg aat ttt gag cca aat aaa gtg aat att caa aag aaa aac tgc       2064
Thr Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys           
        675                 680                 685                       

cat atg gag gga aag gaa aca gta tgc ata aat gct aca gtg tgt ttt       2112
His Met Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Val Cys Phe           
    690                 695                 700                           

gat gtg aaa tta aag tct aaa gaa gac acg att tat gaa gct gat ttg       2160
Asp Val Lys Leu Lys Ser Lys Glu Asp Thr Ile Tyr Glu Ala Asp Leu           
705                 710                 715                 720           

cag tac cgt gtc acc cta gat tca cta aga caa ata tca cga agt ttt       2208
Gln Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe           
                725                 730                 735               

ttc tct gga act caa gag aga aag gtt caa agg aac atc aca gtt cga       2256
Phe Ser Gly Thr Gln Glu Arg Lys Val Gln Arg Asn Ile Thr Val Arg           
            740                 745                 750                   

aaa tca gaa tgc act aag cac tcc ttc tac atg ttg gac aag cat gac       2304
Lys Ser Glu Cys Thr Lys His Ser Phe Tyr Met Leu Asp Lys His Asp           
        755                 760                 765                       

ttt cag gac tct gtg aga ata acg ttg gac ttt aat ctt acc gat cca       2352
Phe Gln Asp Ser Val Arg Ile Thr Leu Asp Phe Asn Leu Thr Asp Pro           
    770                 775                 780                           

gaa aat ggg cct gtt ctt gat gat tct cta cca aac tca gta cat gaa       2400
Glu Asn Gly Pro Val Leu Asp Asp Ser Leu Pro Asn Ser Val His Glu           
785                 790                 795                 800           

tat att ccc ttt gcc aaa gat tgt gga aat aag gaa aaa tgt atc tca       2448
Tyr Ile Pro Phe Ala Lys Asp Cys Gly Asn Lys Glu Lys Cys Ile Ser           
                805                 810                 815               

gac ctc agc ctg cat gtc gcc acc act gaa aag gac ctg ctg att gtc       2496
Asp Leu Ser Leu His Val Ala Thr Thr Glu Lys Asp Leu Leu Ile Val           
            820                 825                 830                   

cga tcc cag aat gat aag ttc aac gtt agc ctc aca gtc aaa aat aca       2544
Arg Ser Gln Asn Asp Lys Phe Asn Val Ser Leu Thr Val Lys Asn Thr           
        835                 840                 845                       

aag gac agt gcc tat aac acc agg aca ata gtg cat tat tct cca aat       2592
Lys Asp Ser Ala Tyr Asn Thr Arg Thr Ile Val His Tyr Ser Pro Asn           
    850                 855                 860                           

cta gtt ttt tca gga att gag gct atc caa aaa gac agt tgt gaa tct       2640
Leu Val Phe Ser Gly Ile Glu Ala Ile Gln Lys Asp Ser Cys Glu Ser           
865                 870                 875                 880           

aat cat aat atc aca tgt aaa gtt gga tat ccc ttc ctg aga aga gga       2688
Asn His Asn Ile Thr Cys Lys Val Gly Tyr Pro Phe Leu Arg Arg Gly           
                885                 890                 895               

gag atg gta act ttc aaa ata ttg ttt cag ttt aac aca tcc tat ctc       2736
Glu Met Val Thr Phe Lys Ile Leu Phe Gln Phe Asn Thr Ser Tyr Leu           
            900                 905                 910                   

atg gaa aat gtg acc att tat tta agt gca aca agt gac agc gaa gaa       2784
Met Glu Asn Val Thr Ile Tyr Leu Ser Ala Thr Ser Asp Ser Glu Glu           
        915                 920                 925                       

cct cct gaa acc ctt tct gat aat gta gta aac att tct atc ccg gta       2832
Pro Pro Glu Thr Leu Ser Asp Asn Val Val Asn Ile Ser Ile Pro Val           
    930                 935                 940                           

aaa tat gaa gtt gga cta cag ttt tac agc tct gca agt gaa tac cac       2880
Lys Tyr Glu Val Gly Leu Gln Phe Tyr Ser Ser Ala Ser Glu Tyr His           
945                 950                 955                 960           

att tca att gct gcc aat gag aca gtc cct gaa gtt att aat tct act       2928
Ile Ser Ile Ala Ala Asn Glu Thr Val Pro Glu Val Ile Asn Ser Thr           
                965                 970                 975               

gag gac att gga aat gaa att aat atc ttc tac ttg att aga aaa agt       2976
Glu Asp Ile Gly Asn Glu Ile Asn Ile Phe Tyr Leu Ile Arg Lys Ser           
            980                 985                 990                   

gga tct ttt cca atg cca gag ctt  aag ctg tca att tca  ttc ccc aat     3024
Gly Ser Phe Pro Met Pro Glu Leu  Lys Leu Ser Ile Ser  Phe Pro Asn         
        995                 1000                 1005                     

atg aca  tca aat ggt tac cct  gtg ctg tac cca act  gga ttg tca        3069
Met Thr  Ser Asn Gly Tyr Pro  Val Leu Tyr Pro Thr  Gly Leu Ser            
    1010                 1015                 1020                        

tct tct  gag aat gca aac tgc  aga ccc cat atc ttt  gag gat cct        3114
Ser Ser  Glu Asn Ala Asn Cys  Arg Pro His Ile Phe  Glu Asp Pro            
    1025                 1030                 1035                        

ttc agt  atc aac tct gga aag  aaa atg act aca tca  act gac cat        3159
Phe Ser  Ile Asn Ser Gly Lys  Lys Met Thr Thr Ser  Thr Asp His            
    1040                 1045                 1050                        

ctc aaa  cga ggc aca att ctg  gac tgc aat aca tgt  aaa ttt gct        3204
Leu Lys  Arg Gly Thr Ile Leu  Asp Cys Asn Thr Cys  Lys Phe Ala            
    1055                 1060                 1065                        

acc atc  aca tgt aat ctc act  tct tct gac atc agc  caa gtc aat        3249
Thr Ile  Thr Cys Asn Leu Thr  Ser Ser Asp Ile Ser  Gln Val Asn            
    1070                 1075                 1080                        

gtt tcg  ctt atc ttg tgg aaa  cca act ttt ata aaa  tca tat ttt        3294
Val Ser  Leu Ile Leu Trp Lys  Pro Thr Phe Ile Lys  Ser Tyr Phe            
    1085                 1090                 1095                        

tcc agc  tta aat ctt act ata  agg gga gaa ctt cgg  agt gaa aat        3339
Ser Ser  Leu Asn Leu Thr Ile  Arg Gly Glu Leu Arg  Ser Glu Asn            
    1100                 1105                 1110                        

gca tct  ctg gtt tta agt agc  agc aat caa aaa aga  gag ctt gct        3384
Ala Ser  Leu Val Leu Ser Ser  Ser Asn Gln Lys Arg  Glu Leu Ala            
    1115                 1120                 1125                        

att caa  ata tcc aaa gat ggg  cta ccg ggc aga gtg  cca tta tgg        3429
Ile Gln  Ile Ser Lys Asp Gly  Leu Pro Gly Arg Val  Pro Leu Trp            
    1130                 1135                 1140                        

gtc atc  ctg ctg agt gct ttt  gcc gga ttg ttg ctg  tta atg ctg        3474
Val Ile  Leu Leu Ser Ala Phe  Ala Gly Leu Leu Leu  Leu Met Leu            
    1145                 1150                 1155                        

ctc att  tta gca ctg tgg aag  att gga ttc ttc aaa  aga cca ctg        3519
Leu Ile  Leu Ala Leu Trp Lys  Ile Gly Phe Phe Lys  Arg Pro Leu            
    1160                 1165                 1170                        

aaa aag  aaa atg gag aaa                                              3537
Lys Lys  Lys Met Glu Lys                                                  
    1175                                                                  


<210>  4
<211>  1179
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Pro Arg Pro Arg Ala Arg Pro Gly Val Ala Val Ala Cys Cys 
1               5                   10                  15      


Trp Leu Leu Thr Val Val Leu Arg Cys Cys Val Ser Phe Asn Val Asp 
            20                  25                  30          


Val Lys Asn Ser Met Thr Phe Ser Gly Pro Val Glu Asp Met Phe Gly 
        35                  40                  45              


Tyr Thr Val Gln Gln Tyr Glu Asn Glu Glu Gly Lys Trp Val Leu Ile 
    50                  55                  60                  


Gly Ser Pro Leu Val Gly Gln Pro Lys Asn Arg Thr Gly Asp Val Tyr 
65                  70                  75                  80  


Lys Cys Pro Val Gly Arg Gly Glu Ser Leu Pro Cys Val Lys Leu Asp 
                85                  90                  95      


Leu Pro Val Asn Thr Ser Ile Pro Asn Val Thr Glu Val Lys Glu Asn 
            100                 105                 110         


Met Thr Phe Gly Ser Thr Leu Val Thr Asn Pro Asn Gly Gly Phe Leu 
        115                 120                 125             


Ala Cys Gly Pro Leu Tyr Ala Tyr Arg Cys Gly His Leu His Tyr Thr 
    130                 135                 140                 


Thr Gly Ile Cys Ser Asp Val Ser Pro Thr Phe Gln Val Val Asn Ser 
145                 150                 155                 160 


Ile Ala Pro Val Gln Glu Cys Ser Thr Gln Leu Asp Ile Val Ile Val 
                165                 170                 175     


Leu Asp Gly Ser Asn Ser Ile Tyr Pro Trp Asp Ser Val Thr Ala Phe 
            180                 185                 190         


Leu Asn Asp Leu Leu Glu Arg Met Asp Ile Gly Pro Lys Gln Thr Gln 
        195                 200                 205             


Val Gly Ile Val Gln Tyr Gly Glu Asn Val Thr His Glu Phe Asn Leu 
    210                 215                 220                 


Asn Lys Tyr Ser Ser Thr Glu Glu Val Leu Val Ala Ala Lys Lys Ile 
225                 230                 235                 240 


Val Gln Arg Gly Gly Arg Gln Thr Met Thr Ala Leu Gly Ile Asp Thr 
                245                 250                 255     


Ala Arg Lys Glu Ala Phe Thr Glu Ala Arg Gly Ala Arg Arg Gly Val 
            260                 265                 270         


Lys Lys Val Met Val Ile Val Thr Asp Gly Glu Ser His Asp Asn His 
        275                 280                 285             


Arg Leu Lys Lys Val Ile Gln Asp Cys Glu Asp Glu Asn Ile Gln Arg 
    290                 295                 300                 


Phe Ser Ile Ala Ile Leu Gly Ser Tyr Asn Arg Gly Asn Leu Ser Thr 
305                 310                 315                 320 


Glu Lys Phe Val Glu Glu Ile Lys Ser Ile Ala Ser Glu Pro Thr Glu 
                325                 330                 335     


Lys His Phe Phe Asn Val Ser Asp Glu Leu Ala Leu Val Thr Ile Val 
            340                 345                 350         


Lys Thr Leu Gly Glu Arg Ile Phe Ala Leu Glu Ala Thr Ala Asp Gln 
        355                 360                 365             


Ser Ala Ala Ser Phe Glu Met Glu Met Ser Gln Thr Gly Phe Ser Ala 
    370                 375                 380                 


His Tyr Ser Gln Asp Trp Val Met Leu Gly Ala Val Gly Ala Tyr Asp 
385                 390                 395                 400 


Trp Asn Gly Thr Val Val Met Gln Lys Ala Ser Gln Ile Ile Ile Pro 
                405                 410                 415     


Arg Asn Thr Thr Phe Asn Val Glu Ser Thr Lys Lys Asn Glu Pro Leu 
            420                 425                 430         


Ala Ser Tyr Leu Gly Tyr Thr Val Asn Ser Ala Thr Ala Ser Ser Gly 
        435                 440                 445             


Asp Val Leu Tyr Ile Ala Gly Gln Pro Arg Tyr Asn His Thr Gly Gln 
    450                 455                 460                 


Val Ile Ile Tyr Arg Met Glu Asp Gly Asn Ile Lys Ile Leu Gln Thr 
465                 470                 475                 480 


Leu Ser Gly Glu Gln Ile Gly Ser Tyr Phe Gly Ser Ile Leu Thr Thr 
                485                 490                 495     


Thr Asp Ile Asp Lys Asp Ser Asn Thr Asp Ile Leu Leu Val Gly Ala 
            500                 505                 510         


Pro Met Tyr Met Gly Thr Glu Lys Glu Glu Gln Gly Lys Val Tyr Val 
        515                 520                 525             


Tyr Ala Leu Asn Gln Thr Arg Phe Glu Tyr Gln Met Ser Leu Glu Pro 
    530                 535                 540                 


Ile Lys Gln Thr Cys Cys Ser Ser Arg Gln His Asn Ser Cys Thr Thr 
545                 550                 555                 560 


Glu Asn Lys Asn Glu Pro Cys Gly Ala Arg Phe Gly Thr Ala Ile Ala 
                565                 570                 575     


Ala Val Lys Asp Leu Asn Leu Asp Gly Phe Asn Asp Ile Val Ile Gly 
            580                 585                 590         


Ala Pro Leu Glu Asp Asp His Gly Gly Ala Val Tyr Ile Tyr His Gly 
        595                 600                 605             


Ser Gly Lys Thr Ile Arg Lys Glu Tyr Ala Gln Arg Ile Pro Ser Gly 
    610                 615                 620                 


Gly Asp Gly Lys Thr Leu Lys Phe Phe Gly Gln Ser Ile His Gly Glu 
625                 630                 635                 640 


Met Asp Leu Asn Gly Asp Gly Leu Thr Asp Val Thr Ile Gly Gly Leu 
                645                 650                 655     


Gly Gly Ala Ala Leu Phe Trp Ser Arg Asp Val Ala Val Val Lys Val 
            660                 665                 670         


Thr Met Asn Phe Glu Pro Asn Lys Val Asn Ile Gln Lys Lys Asn Cys 
        675                 680                 685             


His Met Glu Gly Lys Glu Thr Val Cys Ile Asn Ala Thr Val Cys Phe 
    690                 695                 700                 


Asp Val Lys Leu Lys Ser Lys Glu Asp Thr Ile Tyr Glu Ala Asp Leu 
705                 710                 715                 720 


Gln Tyr Arg Val Thr Leu Asp Ser Leu Arg Gln Ile Ser Arg Ser Phe 
                725                 730                 735     


Phe Ser Gly Thr Gln Glu Arg Lys Val Gln Arg Asn Ile Thr Val Arg 
            740                 745                 750         


Lys Ser Glu Cys Thr Lys His Ser Phe Tyr Met Leu Asp Lys His Asp 
        755                 760                 765             


Phe Gln Asp Ser Val Arg Ile Thr Leu Asp Phe Asn Leu Thr Asp Pro 
    770                 775                 780                 


Glu Asn Gly Pro Val Leu Asp Asp Ser Leu Pro Asn Ser Val His Glu 
785                 790                 795                 800 


Tyr Ile Pro Phe Ala Lys Asp Cys Gly Asn Lys Glu Lys Cys Ile Ser 
                805                 810                 815     


Asp Leu Ser Leu His Val Ala Thr Thr Glu Lys Asp Leu Leu Ile Val 
            820                 825                 830         


Arg Ser Gln Asn Asp Lys Phe Asn Val Ser Leu Thr Val Lys Asn Thr 
        835                 840                 845             


Lys Asp Ser Ala Tyr Asn Thr Arg Thr Ile Val His Tyr Ser Pro Asn 
    850                 855                 860                 


Leu Val Phe Ser Gly Ile Glu Ala Ile Gln Lys Asp Ser Cys Glu Ser 
865                 870                 875                 880 


Asn His Asn Ile Thr Cys Lys Val Gly Tyr Pro Phe Leu Arg Arg Gly 
                885                 890                 895     


Glu Met Val Thr Phe Lys Ile Leu Phe Gln Phe Asn Thr Ser Tyr Leu 
            900                 905                 910         


Met Glu Asn Val Thr Ile Tyr Leu Ser Ala Thr Ser Asp Ser Glu Glu 
        915                 920                 925             


Pro Pro Glu Thr Leu Ser Asp Asn Val Val Asn Ile Ser Ile Pro Val 
    930                 935                 940                 


Lys Tyr Glu Val Gly Leu Gln Phe Tyr Ser Ser Ala Ser Glu Tyr His 
945                 950                 955                 960 


Ile Ser Ile Ala Ala Asn Glu Thr Val Pro Glu Val Ile Asn Ser Thr 
                965                 970                 975     


Glu Asp Ile Gly Asn Glu Ile Asn Ile Phe Tyr Leu Ile Arg Lys Ser 
            980                 985                 990         


Gly Ser Phe Pro Met Pro Glu Leu  Lys Leu Ser Ile Ser  Phe Pro Asn 
        995                 1000                 1005             


Met Thr  Ser Asn Gly Tyr Pro  Val Leu Tyr Pro Thr  Gly Leu Ser 
    1010                 1015                 1020             


Ser Ser  Glu Asn Ala Asn Cys  Arg Pro His Ile Phe  Glu Asp Pro 
    1025                 1030                 1035             


Phe Ser  Ile Asn Ser Gly Lys  Lys Met Thr Thr Ser  Thr Asp His 
    1040                 1045                 1050             


Leu Lys  Arg Gly Thr Ile Leu  Asp Cys Asn Thr Cys  Lys Phe Ala 
    1055                 1060                 1065             


Thr Ile  Thr Cys Asn Leu Thr  Ser Ser Asp Ile Ser  Gln Val Asn 
    1070                 1075                 1080             


Val Ser  Leu Ile Leu Trp Lys  Pro Thr Phe Ile Lys  Ser Tyr Phe 
    1085                 1090                 1095             


Ser Ser  Leu Asn Leu Thr Ile  Arg Gly Glu Leu Arg  Ser Glu Asn 
    1100                 1105                 1110             


Ala Ser  Leu Val Leu Ser Ser  Ser Asn Gln Lys Arg  Glu Leu Ala 
    1115                 1120                 1125             


Ile Gln  Ile Ser Lys Asp Gly  Leu Pro Gly Arg Val  Pro Leu Trp 
    1130                 1135                 1140             


Val Ile  Leu Leu Ser Ala Phe  Ala Gly Leu Leu Leu  Leu Met Leu 
    1145                 1150                 1155             


Leu Ile  Leu Ala Leu Trp Lys  Ile Gly Phe Phe Lys  Arg Pro Leu 
    1160                 1165                 1170             


Lys Lys  Lys Met Glu Lys 
    1175                 


<210>  5
<211>  1407
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1407)

<400>  5
atg cac agc ttt cct cca ctg ctg ctg ctg ctg ttc tgg ggt gtg gtg         48
Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val           
1               5                   10                  15                

tct cac agc ttc cca gcg act cta gaa aca caa gag caa gat gtg gac         96
Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp           
            20                  25                  30                    

tta gtc cag aaa tac ctg gaa aaa tac tac aac ctg aag aat gat ggg        144
Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly           
        35                  40                  45                        

agg caa gtt gaa aag cgg aga aat agt ggc cca gtg gtt gaa aaa ttg        192
Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu           
    50                  55                  60                            

aag caa atg cag gaa ttc ttt ggg ctg aaa gtg act ggg aaa cca gat        240
Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp           
65                  70                  75                  80            

gct gaa acc ctg aag gtg atg aag cag ccc aga tgt gga gtg cct gat        288
Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp           
                85                  90                  95                

gtg gct cag ttt gtc ctc act gag ggg aac cct cgc tgg gag caa aca        336
Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr           
            100                 105                 110                   

cat ctg acc tac agg att gaa aat tac acg cca gat ttg cca aga gca        384
His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala           
        115                 120                 125                       

gat gtg gac cat gcc att gag aaa gcc ttc caa ctc tgg agt aat gtc        432
Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val           
    130                 135                 140                           

aca cct ctg aca ttc acc aag gtc tct gag ggt caa gca gac atc atg        480
Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met           
145                 150                 155                 160           

ata tct ttt gtc agg gga gat cat cgg gac aac tct cct ttt gat gga        528
Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly           
                165                 170                 175               

cct gga gga aat ctt gct cat gct ttt caa cca ggc cca ggt att gga        576
Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly           
            180                 185                 190                   

ggg gat gct cat ttt gat gaa gat gaa agg tgg acc aac aat ttc aga        624
Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg           
        195                 200                 205                       

gag tac aac tta cat cgt gtt gca gct cat gaa ctc ggc cat tct ctt        672
Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu           
    210                 215                 220                           

gga ctc tcc cat tct act gat atc ggg gct ttg atg tac cct agc tac        720
Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr           
225                 230                 235                 240           

acc ttc agt ggt gat gtt cag cta gct cag gat gac att gat ggc atc        768
Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile           
                245                 250                 255               

caa gcc ata tat gga cgt tcc caa aat cct gtc cag ccc atc ggc cca        816
Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro           
            260                 265                 270                   

caa acc cca aaa gcg tgt gac agt aag cta acc ttt gat gct ata act        864
Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr           
        275                 280                 285                       

acg att cgg gga gaa gtg atg ttc ttt aaa gac aga ttc tac atg cgc        912
Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg           
    290                 295                 300                           

aca aat ccc ttc tac ccg gaa gtt gag ctc aat ttc att tct gtt ttc        960
Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe           
305                 310                 315                 320           

tgg cca caa ctg cca aat ggg ctt gaa gct gct tac gaa ttt gcc gac       1008
Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp           
                325                 330                 335               

aga gat gaa gtc cgg ttt ttc aaa ggg aat aag tac tgg gct gtt cag       1056
Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln           
            340                 345                 350                   

gga cag aat gtg cta cac gga tac ccc aag gac atc tac agc tcc ttt       1104
Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe           
        355                 360                 365                       

ggc ttc cct aga act gtg aag cat atc gat gct gct ctt tct gag gaa       1152
Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu           
    370                 375                 380                           

aac act gga aaa acc tac ttc ttt gtt gct aac aaa tac tgg agg tat       1200
Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr           
385                 390                 395                 400           

gat gaa tat aaa cga tct atg gat cca ggt tat ccc aaa atg ata gca       1248
Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala           
                405                 410                 415               

cat gac ttt cct gga att ggc cac aaa gtt gat gca gtt ttc atg aaa       1296
His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys           
            420                 425                 430                   

gat gga ttt ttc tat ttc ttt cat gga aca aga caa tac aaa ttt gat       1344
Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp           
        435                 440                 445                       

cct aaa acg aag aga att ttg act ctc cag aaa gct aat agc tgg ttc       1392
Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe           
    450                 455                 460                           

aac tgc agg aaa aat                                                   1407
Asn Cys Arg Lys Asn                                                       
465                                                                       


<210>  6
<211>  469
<212>  PRT
<213>  Homo sapiens

<400>  6

Met His Ser Phe Pro Pro Leu Leu Leu Leu Leu Phe Trp Gly Val Val 
1               5                   10                  15      


Ser His Ser Phe Pro Ala Thr Leu Glu Thr Gln Glu Gln Asp Val Asp 
            20                  25                  30          


Leu Val Gln Lys Tyr Leu Glu Lys Tyr Tyr Asn Leu Lys Asn Asp Gly 
        35                  40                  45              


Arg Gln Val Glu Lys Arg Arg Asn Ser Gly Pro Val Val Glu Lys Leu 
    50                  55                  60                  


Lys Gln Met Gln Glu Phe Phe Gly Leu Lys Val Thr Gly Lys Pro Asp 
65                  70                  75                  80  


Ala Glu Thr Leu Lys Val Met Lys Gln Pro Arg Cys Gly Val Pro Asp 
                85                  90                  95      


Val Ala Gln Phe Val Leu Thr Glu Gly Asn Pro Arg Trp Glu Gln Thr 
            100                 105                 110         


His Leu Thr Tyr Arg Ile Glu Asn Tyr Thr Pro Asp Leu Pro Arg Ala 
        115                 120                 125             


Asp Val Asp His Ala Ile Glu Lys Ala Phe Gln Leu Trp Ser Asn Val 
    130                 135                 140                 


Thr Pro Leu Thr Phe Thr Lys Val Ser Glu Gly Gln Ala Asp Ile Met 
145                 150                 155                 160 


Ile Ser Phe Val Arg Gly Asp His Arg Asp Asn Ser Pro Phe Asp Gly 
                165                 170                 175     


Pro Gly Gly Asn Leu Ala His Ala Phe Gln Pro Gly Pro Gly Ile Gly 
            180                 185                 190         


Gly Asp Ala His Phe Asp Glu Asp Glu Arg Trp Thr Asn Asn Phe Arg 
        195                 200                 205             


Glu Tyr Asn Leu His Arg Val Ala Ala His Glu Leu Gly His Ser Leu 
    210                 215                 220                 


Gly Leu Ser His Ser Thr Asp Ile Gly Ala Leu Met Tyr Pro Ser Tyr 
225                 230                 235                 240 


Thr Phe Ser Gly Asp Val Gln Leu Ala Gln Asp Asp Ile Asp Gly Ile 
                245                 250                 255     


Gln Ala Ile Tyr Gly Arg Ser Gln Asn Pro Val Gln Pro Ile Gly Pro 
            260                 265                 270         


Gln Thr Pro Lys Ala Cys Asp Ser Lys Leu Thr Phe Asp Ala Ile Thr 
        275                 280                 285             


Thr Ile Arg Gly Glu Val Met Phe Phe Lys Asp Arg Phe Tyr Met Arg 
    290                 295                 300                 


Thr Asn Pro Phe Tyr Pro Glu Val Glu Leu Asn Phe Ile Ser Val Phe 
305                 310                 315                 320 


Trp Pro Gln Leu Pro Asn Gly Leu Glu Ala Ala Tyr Glu Phe Ala Asp 
                325                 330                 335     


Arg Asp Glu Val Arg Phe Phe Lys Gly Asn Lys Tyr Trp Ala Val Gln 
            340                 345                 350         


Gly Gln Asn Val Leu His Gly Tyr Pro Lys Asp Ile Tyr Ser Ser Phe 
        355                 360                 365             


Gly Phe Pro Arg Thr Val Lys His Ile Asp Ala Ala Leu Ser Glu Glu 
    370                 375                 380                 


Asn Thr Gly Lys Thr Tyr Phe Phe Val Ala Asn Lys Tyr Trp Arg Tyr 
385                 390                 395                 400 


Asp Glu Tyr Lys Arg Ser Met Asp Pro Gly Tyr Pro Lys Met Ile Ala 
                405                 410                 415     


His Asp Phe Pro Gly Ile Gly His Lys Val Asp Ala Val Phe Met Lys 
            420                 425                 430         


Asp Gly Phe Phe Tyr Phe Phe His Gly Thr Arg Gln Tyr Lys Phe Asp 
        435                 440                 445             


Pro Lys Thr Lys Arg Ile Leu Thr Leu Gln Lys Ala Asn Ser Trp Phe 
    450                 455                 460                 


Asn Cys Arg Lys Asn 
465                 


<210>  7
<211>  1392
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(1392)

<400>  7
atg cct agc ctt cct ttg ctg ttg ctt ctc tgg gct gct agc tca tac         48
Met Pro Ser Leu Pro Leu Leu Leu Leu Leu Trp Ala Ala Ser Ser Tyr           
1               5                   10                  15                

agt ttc cct gtg ttt cac aac gga gac cgg caa aat gtg gag aca gtc         96
Ser Phe Pro Val Phe His Asn Gly Asp Arg Gln Asn Val Glu Thr Val           
            20                  25                  30                    

tgg aaa tac ctg gaa aac tac tac aac ttg ggc aaa aac atg caa gct        144
Trp Lys Tyr Leu Glu Asn Tyr Tyr Asn Leu Gly Lys Asn Met Gln Ala           
        35                  40                  45                        

aaa aac gtg aat ggc aag gag atg atg gct gaa aag ctg agg caa atg        192
Lys Asn Val Asn Gly Lys Glu Met Met Ala Glu Lys Leu Arg Gln Met           
    50                  55                  60                            

cag cag tta ttt ggg ctg aaa gtg act gga aat tca gat cct gaa acc        240
Gln Gln Leu Phe Gly Leu Lys Val Thr Gly Asn Ser Asp Pro Glu Thr           
65                  70                  75                  80            

ctg aga gct atg aag aag ccc agg tgt ggg gtg cct gat gtg gcc cca        288
Leu Arg Ala Met Lys Lys Pro Arg Cys Gly Val Pro Asp Val Ala Pro           
                85                  90                  95                

tat gcc att act cac aac aat cct cgt tgg acc aaa aca cat ctg aca        336
Tyr Ala Ile Thr His Asn Asn Pro Arg Trp Thr Lys Thr His Leu Thr           
            100                 105                 110                   

tac agc att tta aac tac aca cca tat ttg cca aaa gca gtt gtg gaa        384
Tyr Ser Ile Leu Asn Tyr Thr Pro Tyr Leu Pro Lys Ala Val Val Glu           
        115                 120                 125                       

gat gcc atc gcg aga gcc ttt aga gtc tgg agt gat gtg aca cca ctt        432
Asp Ala Ile Ala Arg Ala Phe Arg Val Trp Ser Asp Val Thr Pro Leu           
    130                 135                 140                           

acg ttc caa aga gtc ttt gag gag gaa ggc gat att gtg ctc tcc ttc        480
Thr Phe Gln Arg Val Phe Glu Glu Glu Gly Asp Ile Val Leu Ser Phe           
145                 150                 155                 160           

cac aga gga gac cat ggt gac aac aac cca ttt gat gga cct aac tat        528
His Arg Gly Asp His Gly Asp Asn Asn Pro Phe Asp Gly Pro Asn Tyr           
                165                 170                 175               

aag ctt gct cac act ttc cag cca ggc cca ggt ttg ggg ggt gat gtt        576
Lys Leu Ala His Thr Phe Gln Pro Gly Pro Gly Leu Gly Gly Asp Val           
            180                 185                 190                   

cat tat gac ctt gat gag acg tgg acc aac agc agt gaa aat ttc aac        624
His Tyr Asp Leu Asp Glu Thr Trp Thr Asn Ser Ser Glu Asn Phe Asn           
        195                 200                 205                       

ttg ttc tat gtt acg gct cat gaa ctg ggt cac tcc ctt ggg ctc act        672
Leu Phe Tyr Val Thr Ala His Glu Leu Gly His Ser Leu Gly Leu Thr           
    210                 215                 220                           

cat tct agt gat ata gga gca cta atg ttc ccc agt tac acg tgg tac        720
His Ser Ser Asp Ile Gly Ala Leu Met Phe Pro Ser Tyr Thr Trp Tyr           
225                 230                 235                 240           

act gaa gac ttt gtg cta aac cag gat gat att aat cgc atc cag gac        768
Thr Glu Asp Phe Val Leu Asn Gln Asp Asp Ile Asn Arg Ile Gln Asp           
                245                 250                 255               

tta tat gga cct tcc cca aat ccc atc cag cca aca ggt gca aca aca        816
Leu Tyr Gly Pro Ser Pro Asn Pro Ile Gln Pro Thr Gly Ala Thr Thr           
            260                 265                 270                   

cca cat cca tgt aat ggt gat cta acc ttt gat gct ata act aca ttt        864
Pro His Pro Cys Asn Gly Asp Leu Thr Phe Asp Ala Ile Thr Thr Phe           
        275                 280                 285                       

agg gga gag gtg ttt ttc ttc aaa ggc agg ttc tac att cgg gta aat        912
Arg Gly Glu Val Phe Phe Phe Lys Gly Arg Phe Tyr Ile Arg Val Asn           
    290                 295                 300                           

aga ttc atg cca gaa cct gag ctc aat tta ata ggt att ctc tgg cca        960
Arg Phe Met Pro Glu Pro Glu Leu Asn Leu Ile Gly Ile Leu Trp Pro           
305                 310                 315                 320           

aat ctt cca gtt aaa ctt gac gct gct tat gaa gct agt atg ata gat       1008
Asn Leu Pro Val Lys Leu Asp Ala Ala Tyr Glu Ala Ser Met Ile Asp           
                325                 330                 335               

caa gtc cgc tat ttc aaa ggc agc aaa gta tgg gct gtt caa gag cag       1056
Gln Val Arg Tyr Phe Lys Gly Ser Lys Val Trp Ala Val Gln Glu Gln           
            340                 345                 350                   

agt gta ctg aga gga ttc ccc aga gac atc cac agt ttc ttt ggc ttc       1104
Ser Val Leu Arg Gly Phe Pro Arg Asp Ile His Ser Phe Phe Gly Phe           
        355                 360                 365                       

cct agc aat gtg aca cac att gat gct gct gtt tgt gag gaa gag act       1152
Pro Ser Asn Val Thr His Ile Asp Ala Ala Val Cys Glu Glu Glu Thr           
    370                 375                 380                           

gga aaa aca tac ttc ttt gtt gac cac atg tac tgg agg tat gat gaa       1200
Gly Lys Thr Tyr Phe Phe Val Asp His Met Tyr Trp Arg Tyr Asp Glu           
385                 390                 395                 400           

aat aca cag tct atg gat cca ggt tat ccc aga tta aca gca gaa gac       1248
Asn Thr Gln Ser Met Asp Pro Gly Tyr Pro Arg Leu Thr Ala Glu Asp           
                405                 410                 415               

ttc cct gga att gat gat aaa gtt gat gat gtt ttc caa aaa gga gaa       1296
Phe Pro Gly Ile Asp Asp Lys Val Asp Asp Val Phe Gln Lys Gly Glu           
            420                 425                 430                   

aat ttc tat ttc ttt cac caa tca gtt caa cac aga ttt aac ctc caa       1344
Asn Phe Tyr Phe Phe His Gln Ser Val Gln His Arg Phe Asn Leu Gln           
        435                 440                 445                       

ata aga aga gtt gat gat tcc cgt gat tct agt aca tgg ttc aac tgc       1392
Ile Arg Arg Val Asp Asp Ser Arg Asp Ser Ser Thr Trp Phe Asn Cys           
    450                 455                 460                           


<210>  8
<211>  464
<212>  PRT
<213>  Mus musculus

<400>  8

Met Pro Ser Leu Pro Leu Leu Leu Leu Leu Trp Ala Ala Ser Ser Tyr 
1               5                   10                  15      


Ser Phe Pro Val Phe His Asn Gly Asp Arg Gln Asn Val Glu Thr Val 
            20                  25                  30          


Trp Lys Tyr Leu Glu Asn Tyr Tyr Asn Leu Gly Lys Asn Met Gln Ala 
        35                  40                  45              


Lys Asn Val Asn Gly Lys Glu Met Met Ala Glu Lys Leu Arg Gln Met 
    50                  55                  60                  


Gln Gln Leu Phe Gly Leu Lys Val Thr Gly Asn Ser Asp Pro Glu Thr 
65                  70                  75                  80  


Leu Arg Ala Met Lys Lys Pro Arg Cys Gly Val Pro Asp Val Ala Pro 
                85                  90                  95      


Tyr Ala Ile Thr His Asn Asn Pro Arg Trp Thr Lys Thr His Leu Thr 
            100                 105                 110         


Tyr Ser Ile Leu Asn Tyr Thr Pro Tyr Leu Pro Lys Ala Val Val Glu 
        115                 120                 125             


Asp Ala Ile Ala Arg Ala Phe Arg Val Trp Ser Asp Val Thr Pro Leu 
    130                 135                 140                 


Thr Phe Gln Arg Val Phe Glu Glu Glu Gly Asp Ile Val Leu Ser Phe 
145                 150                 155                 160 


His Arg Gly Asp His Gly Asp Asn Asn Pro Phe Asp Gly Pro Asn Tyr 
                165                 170                 175     


Lys Leu Ala His Thr Phe Gln Pro Gly Pro Gly Leu Gly Gly Asp Val 
            180                 185                 190         


His Tyr Asp Leu Asp Glu Thr Trp Thr Asn Ser Ser Glu Asn Phe Asn 
        195                 200                 205             


Leu Phe Tyr Val Thr Ala His Glu Leu Gly His Ser Leu Gly Leu Thr 
    210                 215                 220                 


His Ser Ser Asp Ile Gly Ala Leu Met Phe Pro Ser Tyr Thr Trp Tyr 
225                 230                 235                 240 


Thr Glu Asp Phe Val Leu Asn Gln Asp Asp Ile Asn Arg Ile Gln Asp 
                245                 250                 255     


Leu Tyr Gly Pro Ser Pro Asn Pro Ile Gln Pro Thr Gly Ala Thr Thr 
            260                 265                 270         


Pro His Pro Cys Asn Gly Asp Leu Thr Phe Asp Ala Ile Thr Thr Phe 
        275                 280                 285             


Arg Gly Glu Val Phe Phe Phe Lys Gly Arg Phe Tyr Ile Arg Val Asn 
    290                 295                 300                 


Arg Phe Met Pro Glu Pro Glu Leu Asn Leu Ile Gly Ile Leu Trp Pro 
305                 310                 315                 320 


Asn Leu Pro Val Lys Leu Asp Ala Ala Tyr Glu Ala Ser Met Ile Asp 
                325                 330                 335     


Gln Val Arg Tyr Phe Lys Gly Ser Lys Val Trp Ala Val Gln Glu Gln 
            340                 345                 350         


Ser Val Leu Arg Gly Phe Pro Arg Asp Ile His Ser Phe Phe Gly Phe 
        355                 360                 365             


Pro Ser Asn Val Thr His Ile Asp Ala Ala Val Cys Glu Glu Glu Thr 
    370                 375                 380                 


Gly Lys Thr Tyr Phe Phe Val Asp His Met Tyr Trp Arg Tyr Asp Glu 
385                 390                 395                 400 


Asn Thr Gln Ser Met Asp Pro Gly Tyr Pro Arg Leu Thr Ala Glu Asp 
                405                 410                 415     


Phe Pro Gly Ile Asp Asp Lys Val Asp Asp Val Phe Gln Lys Gly Glu 
            420                 425                 430         


Asn Phe Tyr Phe Phe His Gln Ser Val Gln His Arg Phe Asn Leu Gln 
        435                 440                 445             


Ile Arg Arg Val Asp Asp Ser Arg Asp Ser Ser Thr Trp Phe Asn Cys 
    450                 455                 460                 


