                         SEQUENCE LISTING

<110>  Janssen Biotech, Inc.
 
<120>  TARGETING WITH FIBRONECTIN TYPE III LIKE DOMAIN MOLECULES

<130>  689303.7WO (JBI5148WOPCT)

<150>  US62/598,652
<151>  2017-12-14

<160>  63    

<170>  PatentIn version 3.5

<210>  1
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P155R8-G3

<400>  1

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Gln Ile Tyr Tyr Ser Glu Leu Leu Ser Tyr Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Asn Gly Val Lys Gly Gly Thr Arg 
65                  70                  75                  80  


Ser Trp Ser Leu Ser Ala Ile Phe Thr Thr 
                85                  90  


<210>  2
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EEB8

<400>  2

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Gln Ile Tyr Tyr Ser Glu Leu Leu Ser Tyr Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Cys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Asn Gly Val Lys Gly Gly Thr Arg 
65                  70                  75                  80  


Ser Trp Ser Leu Ser Ala Ile Phe Thr Thr Ala Pro Ala Pro Ala Pro 
                85                  90                  95      


Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            100                 105                 110         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        115                 120                 125             


Asp Ser Phe Gln Ile Tyr Tyr Ser Glu Leu Leu Ser Tyr Gly Glu Ala 
    130                 135                 140                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
145                 150                 155                 160 


Leu Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Asn Gly Val Lys Gly 
                165                 170                 175     


Gly Thr Arg Ser Trp Ser Leu Ser Ala Ile Phe Thr Thr Ala Pro Ala 
            180                 185                 190         


Pro Ala Pro Ala Pro Ala Pro Thr Ile Asp Glu Trp Leu Leu Lys Glu 
        195                 200                 205             


Ala Lys Glu Lys Ala Ile Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser 
    210                 215                 220                 


Asp Tyr Tyr Phe Asp Leu Ile Asn Lys Ala Lys Thr Val Glu Gly Val 
225                 230                 235                 240 


Asn Ala Leu Lys Asp Glu Ile Leu Lys Ala 
                245                 250 


<210>  3
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EEB9

<400>  3

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Gln Ile Tyr Tyr Ser Glu Leu Leu Ser Tyr Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Cys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Asn Gly Val Lys Gly Gly Thr Arg 
65                  70                  75                  80  


Ser Trp Ser Leu Ser Ala Ile Phe Thr Thr Ala Pro Ala Pro Ala Pro 
                85                  90                  95      


Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            100                 105                 110         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        115                 120                 125             


Asp Ser Phe Gln Ile Tyr Tyr Ser Glu Leu Leu Ser Tyr Gly Glu Ala 
    130                 135                 140                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
145                 150                 155                 160 


Leu Cys Pro Gly Thr Glu Tyr Thr Val Ser Ile Asn Gly Val Lys Gly 
                165                 170                 175     


Gly Thr Arg Ser Trp Ser Leu Ser Ala Ile Phe Thr Thr Ala Pro Ala 
            180                 185                 190         


Pro Ala Pro Ala Pro Ala Pro Thr Ile Asp Glu Trp Leu Leu Lys Glu 
        195                 200                 205             


Ala Lys Glu Lys Ala Ile Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser 
    210                 215                 220                 


Asp Tyr Tyr Phe Asp Leu Ile Asn Lys Ala Lys Thr Val Glu Gly Val 
225                 230                 235                 240 


Asn Ala Leu Lys Asp Glu Ile Leu Lys Ala 
                245                 250 


<210>  4
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EEB11

<400>  4

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Gln Ile Tyr Tyr Ser Glu Leu Leu Ser Tyr Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Cys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Asn Gly Val Lys Gly Gly Thr Arg 
65                  70                  75                  80  


Ser Trp Ser Leu Ser Ala Ile Phe Thr Thr Ala Pro Cys Pro Ala Pro 
                85                  90                  95      


Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            100                 105                 110         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        115                 120                 125             


Asp Ser Phe Gln Ile Tyr Tyr Ser Glu Leu Leu Ser Tyr Gly Glu Ala 
    130                 135                 140                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
145                 150                 155                 160 


Leu Cys Pro Gly Thr Glu Tyr Thr Val Ser Ile Asn Gly Val Lys Gly 
                165                 170                 175     


Gly Thr Arg Ser Trp Ser Leu Ser Ala Ile Phe Thr Thr Ala Pro Ala 
            180                 185                 190         


Pro Ala Pro Ala Pro Ala Pro Thr Ile Asp Glu Trp Leu Leu Lys Glu 
        195                 200                 205             


Ala Lys Glu Lys Ala Ile Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser 
    210                 215                 220                 


Asp Tyr Tyr Phe Asp Leu Ile Asn Lys Ala Lys Thr Val Glu Gly Val 
225                 230                 235                 240 


Asn Ala Leu Lys Asp Glu Ile Leu Lys Ala 
                245                 250 


<210>  5
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EEB10

<400>  5

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Gln Ile Tyr Tyr Ser Glu Leu Leu Ser Tyr Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Cys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Asn Gly Val Lys Gly Gly Thr Arg 
65                  70                  75                  80  


Ser Trp Ser Leu Ser Ala Ile Phe Thr Thr Ala Pro Cys Pro Ala Pro 
                85                  90                  95      


Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val 
            100                 105                 110         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        115                 120                 125             


Asp Ser Phe Gln Ile Tyr Tyr Ser Glu Leu Leu Ser Tyr Gly Glu Ala 
    130                 135                 140                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
145                 150                 155                 160 


Leu Cys Pro Gly Thr Glu Tyr Thr Val Ser Ile Asn Gly Val Lys Gly 
                165                 170                 175     


Gly Thr Arg Ser Trp Ser Leu Ser Ala Ile Phe Thr Thr Ala Pro Cys 
            180                 185                 190         


Pro Ala Pro Ala Pro Ala Pro Thr Ile Asp Glu Trp Leu Leu Lys Glu 
        195                 200                 205             


Ala Lys Glu Lys Ala Ile Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser 
    210                 215                 220                 


Asp Tyr Tyr Phe Asp Leu Ile Asn Lys Ala Lys Thr Val Glu Gly Val 
225                 230                 235                 240 


Asn Ala Leu Lys Asp Glu Ile Leu Lys Ala 
                245                 250 


<210>  6
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ECB166

<400>  6

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Cys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg 
65                  70                  75                  80  


Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro Cys Pro Ala Pro 
                85                  90                  95      


Ala Pro Ala Pro Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val 
            100                 105                 110         


Thr Glu Asp Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe 
        115                 120                 125             


Asp Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala 
    130                 135                 140                 


Ile Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly 
145                 150                 155                 160 


Leu Cys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly 
                165                 170                 175     


Gly His Arg Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Ala Pro Ala 
            180                 185                 190         


Pro Ala Pro Ala Pro Ala Pro Thr Ile Asp Glu Trp Leu Leu Lys Glu 
        195                 200                 205             


Ala Lys Glu Lys Ala Ile Glu Glu Leu Lys Lys Ala Gly Ile Thr Ser 
    210                 215                 220                 


Asp Tyr Tyr Phe Asp Leu Ile Asn Lys Ala Lys Thr Val Glu Gly Val 
225                 230                 235                 240 


Asn Ala Leu Lys Asp Glu Ile Leu Lys Ala 
                245                 250 


<210>  7
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ABDcon12

<400>  7

Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile Glu 
1               5                   10                  15      


Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu Ile 
            20                  25                  30          


Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu Ile 
        35                  40                  45              


Leu Lys Ala 
    50      


<210>  8
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P233FR9P1001_H3-1

<400>  8

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Pro 
            20                  25                  30          


Ile Gly Tyr Trp Glu Trp Asp Asp Asp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr His Val Tyr Ile Ala Gly Val Lys Gly Gly Gln Trp Ser 
65                  70                  75                  80  


Phe Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  9
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P234CR9_H01

<400>  9

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Glu Trp Trp Val Ile Pro Gly Asp Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Asn Ser Gly 
65                  70                  75                  80  


Gln Trp Asn Asp Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95  


<210>  10
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P233FR9_H10

<400>  10

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Ala 
            20                  25                  30          


Ile Gly Tyr Trp Glu Trp Asp Asp Asp Gly Glu Ala Ile Val Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Pro Val Tyr Ile Ala Gly Val Lys Gly Gly Gln Trp Ser 
65                  70                  75                  80  


Phe Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  


<210>  11
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P229CR5P819_H11

<400>  11

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp Ser 
1               5                   10                  15      


Ala Arg Leu Ser Trp Asp Ile Asp Glu Gln Arg Asp Trp Phe Asp Ser 
            20                  25                  30          


Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val 
        35                  40                  45              


Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys 
    50                  55                  60                  


Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Tyr His Val Tyr 
65                  70                  75                  80  


Arg Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90          


<210>  12
<211>  199
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase A

<400>  12

Met Ser His His His His His His Ser Ser Gly Glu Asn Leu Tyr Phe 
1               5                   10                  15      


Gln Ser Lys Pro His Ile Asp Asn Tyr Leu His Asp Lys Asp Lys Asp 
            20                  25                  30          


Glu Lys Ile Glu Gln Tyr Asp Lys Asn Val Lys Glu Gln Ala Ser Lys 
        35                  40                  45              


Asp Lys Lys Gln Gln Ala Lys Pro Gln Ile Pro Lys Asp Lys Ser Lys 
    50                  55                  60                  


Val Ala Gly Tyr Ile Glu Ile Pro Asp Ala Asp Ile Lys Glu Pro Val 
65                  70                  75                  80  


Tyr Pro Gly Pro Ala Thr Arg Glu Gln Leu Asn Arg Gly Val Ser Phe 
                85                  90                  95      


Ala Glu Glu Asn Glu Ser Leu Asp Asp Gln Asn Ile Ser Ile Ala Gly 
            100                 105                 110         


His Thr Phe Ile Asp Arg Pro Asn Tyr Gln Phe Thr Asn Leu Lys Ala 
        115                 120                 125             


Ala Lys Lys Gly Ser Met Val Tyr Phe Lys Val Gly Asn Glu Thr Arg 
    130                 135                 140                 


Lys Tyr Lys Met Thr Ser Ile Arg Asn Val Lys Pro Thr Ala Val Glu 
145                 150                 155                 160 


Val Leu Asp Glu Gln Lys Gly Lys Asp Lys Gln Leu Thr Leu Ile Thr 
                165                 170                 175     


Cys Asp Asp Tyr Asn Glu Glu Thr Gly Val Trp Glu Thr Arg Lys Ile 
            180                 185                 190         


Phe Val Ala Thr Glu Val Lys 
        195                 


<210>  13
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagless Sortase A

<400>  13

Ser Lys Pro His Ile Asp Asn Tyr Leu His Asp Lys Asp Lys Asp Glu 
1               5                   10                  15      


Lys Ile Glu Gln Tyr Asp Lys Asn Val Lys Glu Gln Ala Ser Lys Asp 
            20                  25                  30          


Lys Lys Gln Gln Ala Lys Pro Gln Ile Pro Lys Asp Lys Ser Lys Val 
        35                  40                  45              


Ala Gly Tyr Ile Glu Ile Pro Asp Ala Asp Ile Lys Glu Pro Val Tyr 
    50                  55                  60                  


Pro Gly Pro Ala Thr Arg Glu Gln Leu Asn Arg Gly Val Ser Phe Ala 
65                  70                  75                  80  


Glu Glu Asn Glu Ser Leu Asp Asp Gln Asn Ile Ser Ile Ala Gly His 
                85                  90                  95      


Thr Phe Ile Asp Arg Pro Asn Tyr Gln Phe Thr Asn Leu Lys Ala Ala 
            100                 105                 110         


Lys Lys Gly Ser Met Val Tyr Phe Lys Val Gly Asn Glu Thr Arg Lys 
        115                 120                 125             


Tyr Lys Met Thr Ser Ile Arg Asn Val Lys Pro Thr Ala Val Glu Val 
    130                 135                 140                 


Leu Asp Glu Gln Lys Gly Lys Asp Lys Gln Leu Thr Leu Ile Thr Cys 
145                 150                 155                 160 


Asp Asp Tyr Asn Glu Glu Thr Gly Val Trp Glu Thr Arg Lys Ile Phe 
                165                 170                 175     


Val Ala Thr Glu Val Lys 
            180         


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_cys

<400>  14

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Pro Ser Tyr Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Cys 
            100                 105         


<210>  15
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP7_G04_cys

<400>  15

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Ala His 
65                  70                  75                  80  


Ala Ile Pro Arg Tyr Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Cys 
            100                 105         


<210>  16
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISO124R5AB_D6_cys

<400>  16

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp His Asn His Arg Pro Gln Phe Asp Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Ile Ala Val Pro 
65                  70                  75                  80  


Trp Asn Tyr Gln Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr Gly Gly 
                85                  90                  95      


His His His His His His Gly Gly Cys 
            100                 105 


<210>  17
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP7_G02srt

<400>  17

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Ile Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr His 
65                  70                  75                  80  


Ala Leu Pro Thr Ala Tyr Thr Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly 
            100                 105                 110         


Gly His 
        


<210>  18
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_E08srt

<400>  18

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Ala Ala 
65                  70                  75                  80  


Leu Pro Asn Asn Tyr Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  19
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06srt

<400>  19

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Pro Ser Tyr Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  20
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_F01srt

<400>  20

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Pro Ser Asn Tyr Ile Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  21
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_F02srt

<400>  21

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Asp Gln Tyr Arg Lys Tyr Ala Gly Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr His 
65                  70                  75                  80  


Ala Leu Pro Gln Thr Tyr Gln Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly 
            100                 105                 110         


Gly His 
        


<210>  22
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP7_F11srt

<400>  22

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ile Trp Gly 
65                  70                  75                  80  


Ala Leu Pro Asn Ser Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly 
            100                 105                 110         


Gly His 
        


<210>  23
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A02srt

<400>  23

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Asn Asn 
65                  70                  75                  80  


Ala Leu Pro Arg Trp Tyr Ile Ser Asn Pro Leu Ser Ala Ile Phe Thr 
                85                  90                  95      


Thr Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly 
            100                 105                 110         


Gly His 
        


<210>  24
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_K23A

<400>  24

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Ala His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Pro Ser Tyr Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  25
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_H24A

<400>  25

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys Ala Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Pro Ser Tyr Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  26
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_Y25A

<400>  26

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Ala Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Pro Ser Tyr Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  27
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_R26A

<400>  27

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Ala Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Pro Ser Tyr Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  28
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_P27A

<400>  28

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Ala Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Pro Ser Tyr Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  29
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_G28A

<400>  29

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Ala Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Pro Ser Tyr Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  30
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_R30A

<400>  30

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Ala Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Pro Ser Tyr Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  31
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_V78A

<400>  31

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Ala Thr Ala 
65                  70                  75                  80  


Leu Pro Ser Tyr Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  32
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_T79A

<400>  32

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Ala Ala 
65                  70                  75                  80  


Leu Pro Ser Tyr Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  33
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_L81A

<400>  33

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Ala Pro Ser Tyr Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  34
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_P82A

<400>  34

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Ala Ser Tyr Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  35
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_S83A

<400>  35

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Pro Ala Tyr Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  36
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_Y84A

<400>  36

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Pro Ser Ala Tyr Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  37
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_Y85A

<400>  37

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Pro Ser Tyr Ala Ser Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  38
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ISOP130R5CP6_A06_S86A

<400>  38

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Lys His Tyr Arg Pro Gly Ala Arg Phe Asp 
            20                  25                  30          


Ser Phe Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile 
        35                  40                  45              


Val Leu Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu 
    50                  55                  60                  


Lys Pro Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Val Thr Ala 
65                  70                  75                  80  


Leu Pro Ser Tyr Tyr Ala Ser Asn Pro Leu Ser Ala Ile Phe Thr Thr 
                85                  90                  95      


Gly Gly His His His His His His Gly Gly Leu Pro Glu Thr Gly Gly 
            100                 105                 110         


His 
    


<210>  39
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tencon

<400>  39

Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp Ser 
1               5                   10                  15      


Leu Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe Leu 
            20                  25                  30          


Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Asn Leu Thr 
        35                  40                  45              


Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro Gly 
    50                  55                  60                  


Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val Lys Gly Gly His Arg Ser 
65                  70                  75                  80  


Asn Pro Leu Ser Ala Glu Phe Thr Thr 
                85                  


<210>  40
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  83v10

<400>  40

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Cys Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly 
                85                  90                  95      


Gly His His His His His His 
            100             


<210>  41
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  83v11

<400>  41

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Cys Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly 
                85                  90                  95      


Gly His His His His His His 
            100             


<210>  42
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  83v12

<400>  42

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Cys Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly 
                85                  90                  95      


Gly His His His His His His 
            100             


<210>  43
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  83v13

<400>  43

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Cys Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly 
                85                  90                  95      


Gly His His His His His His 
            100             


<210>  44
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  83v14

<400>  44

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Cys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly 
                85                  90                  95      


Gly His His His His His His 
            100             


<210>  45
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  83v15

<400>  45

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly 
                85                  90                  95      


Gly His His His His His His Cys 
            100                 


<210>  46
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G3

<400>  46

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Arg Val Thr Glu Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Thr Ala Pro Asp Ala Ala Phe Asp Ser Phe 
            20                  25                  30          


Gln Ile Tyr Tyr Ser Glu Leu Leu Ser Tyr Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Asn Gly Val Lys Gly Gly Thr Arg 
65                  70                  75                  80  


Ser Trp Ser Leu Ser Ala Ile Phe Thr Thr Gly Gly His His His His 
                85                  90                  95      


His His Cys 
            


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MALATI-Seq 1


<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2' O methyl

<220>
<221>  modified_base
<222>  (1)..(20)
<223>  phosphorothioate linkage

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2' O methyl

<400>  47
ugccuttagg attctagaca                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MALATI-Seq 2


<220>
<221>  modified_base
<222>  (1)..(5)
<223>  2' O methyl

<220>
<221>  modified_base
<222>  (1)..(20)
<223>  phosphorothioate linkage

<220>
<221>  modified_base
<222>  (16)..(20)
<223>  2' O methyl

<400>  48
ccaggctggt tatgacucag                                                   20


<210>  49
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tagless 83v10

<400>  49

Met Leu Pro Ala Pro Lys Asn Leu Val Val Ser Glu Val Thr Cys Asp 
1               5                   10                  15      


Ser Ala Arg Leu Ser Trp Asp Asp Pro Trp Ala Phe Tyr Glu Ser Phe 
            20                  25                  30          


Leu Ile Gln Tyr Gln Glu Ser Glu Lys Val Gly Glu Ala Ile Val Leu 
        35                  40                  45              


Thr Val Pro Gly Ser Glu Arg Ser Tyr Asp Leu Thr Gly Leu Lys Pro 
    50                  55                  60                  


Gly Thr Glu Tyr Thr Val Ser Ile Tyr Gly Val His Asn Val Tyr Lys 
65                  70                  75                  80  


Asp Thr Asn Met Arg Gly Leu Pro Leu Ser Ala Ile Phe Thr Thr Gly 
                85                  90                  95      


Gly 
    


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FG Loop

<400>  50

Lys Gly Gly His Arg Ser Asn 
1               5           


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC Loop

<400>  51

Thr Ala Pro Asp Ala Ala Phe Asp 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC Loop

<400>  52

Lys His Tyr Arg Pro Gly Ala Arg 
1               5               


<210>  53
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC Loop

<400>  53

His Asn His Arg Pro Gln 
1               5       


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FG Loop

<400>  54

Val Thr Ala Leu Pro Ser Tyr Tyr Ser Ser Asn 
1               5                   10      


<210>  55
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FG Loop

<400>  55

Ala Ala His Ala Ile Pro Arg Tyr Ala Ser Asn 
1               5                   10      


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FG Loop

<400>  56

Ala Ile Ala Val Pro Trp Asn Tyr Gln Ser Asn 
1               5                   10      


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BC Loop

<400>  57

Asp Gln Tyr Arg Lys Tyr Ala Gly 
1               5               


<210>  58
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FG Loop

<400>  58

Val Thr His Ala Leu Pro Thr Ala Tyr Thr Ser Asn 
1               5                   10          


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FG Loop

<400>  59

Val Ala Ala Leu Pro Asn Asn Tyr Ala Ser Asn 
1               5                   10      


<210>  60
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FG Loop

<400>  60

Val Thr His Ala Leu Pro Gln Thr Tyr Gln Ser Asn 
1               5                   10          


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FG Loop

<400>  61

Ile Trp Gly Ala Leu Pro Asn Ser Tyr Ser Ser Asn 
1               5                   10          


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FG Loop

<400>  62

Val Thr Ala Leu Pro Ser Asn Tyr Ile Ser Asn 
1               5                   10      


<210>  63
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FG Loop

<400>  63

Val Asn Asn Ala Leu Pro Arg Trp Tyr Ile Ser Asn 
1               5                   10          


