                         SEQUENCE LISTING

<110>  INOVIO PHARMACEUTICALS, INC
 
<120>  CANCER VACCINES TARGETING LEMD1 AND USES THEREOF

<130>  104409.000449 / INO-1006 WO

<150>  62/598,329
<151>  2017-12-13

<150>  62/598,612
<151>  2017-12-14

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Consensus LEMD1A DNA Sequence

<400>  1
atggactgga cctggattct gttcctggtg gcagcagcaa cacgggtgca ctccgtggac       60

gtgaagtgcc tgtctgattg taagctgcag aaccagctgg agaagctggc ctttagccct      120

ggcgccatcc tgccatccac caggaagctg gccgagaaga agctggtgca gctgctggtg      180

tccccacctt gcgcaccacc cgtgatgaat ggaccccgcg agctggacgg agcacaggat      240

agcgacgatt ccgaggagct gaacatcatc ctgcagggca atatcatcct gtctaccgag      300

aagagcaaga agctgaagaa gcggcccgag gcctctacca caaagcctaa ggccgtggac      360

acatactgcc tggattataa gccatctaag ggccggagat gggcagccag ggccccaagc      420

acccgcatca catacggcac catcacaaag gagcgggact attgtaccga ggatcagaca      480

gccgagagct ggagagagga gggcttccct gtgggcctga agctggccgt gctgggcatc      540

ttcatcatcg tggtgttcgt gtacctgaca gtggagaaca agccactgtt tggctgataa      600


<210>  2
<211>  198
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Consensus LEMD1A Protein Sequence

<400>  2

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Val Asp Val Lys Cys Leu Ser Asp Cys Lys Leu Gln Asn Gln 
            20                  25                  30          


Leu Glu Lys Leu Ala Phe Ser Pro Gly Ala Ile Leu Pro Ser Thr Arg 
        35                  40                  45              


Lys Leu Ala Glu Lys Lys Leu Val Gln Leu Leu Val Ser Pro Pro Cys 
    50                  55                  60                  


Ala Pro Pro Val Met Asn Gly Pro Arg Glu Leu Asp Gly Ala Gln Asp 
65                  70                  75                  80  


Ser Asp Asp Ser Glu Glu Leu Asn Ile Ile Leu Gln Gly Asn Ile Ile 
                85                  90                  95      


Leu Ser Thr Glu Lys Ser Lys Lys Leu Lys Lys Arg Pro Glu Ala Ser 
            100                 105                 110         


Thr Thr Lys Pro Lys Ala Val Asp Thr Tyr Cys Leu Asp Tyr Lys Pro 
        115                 120                 125             


Ser Lys Gly Arg Arg Trp Ala Ala Arg Ala Pro Ser Thr Arg Ile Thr 
    130                 135                 140                 


Tyr Gly Thr Ile Thr Lys Glu Arg Asp Tyr Cys Thr Glu Asp Gln Thr 
145                 150                 155                 160 


Ala Glu Ser Trp Arg Glu Glu Gly Phe Pro Val Gly Leu Lys Leu Ala 
                165                 170                 175     


Val Leu Gly Ile Phe Ile Ile Val Val Phe Val Tyr Leu Thr Val Glu 
            180                 185                 190         


Asn Lys Pro Leu Phe Gly 
        195             


<210>  3
<211>  258
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Consensus LEMD1F DNA Sequence

<400>  3
atggactgga cctggattct gttcctggtg gcagcagcaa caagggtgca ctctgtggac       60

gtgaagtgcc tgagcgattg taagctgcag aaccagctgg agaagctggc cttttcccca      120

ggagcaatcc tgaggggact gcaggagcac caggcaccag agagccacat gggactgtcc      180

cctaagcggg agaccacagc aaggaagacc agactgctga gggcaggaga gaagaaggtg      240

tctcagtggg cctgataa                                                    258


<210>  4
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Consensus LEMD1F Protein Sequence

<400>  4

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Val Asp Val Lys Cys Leu Ser Asp Cys Lys Leu Gln Asn Gln 
            20                  25                  30          


Leu Glu Lys Leu Ala Phe Ser Pro Gly Ala Ile Leu Arg Gly Leu Gln 
        35                  40                  45              


Glu His Gln Ala Pro Glu Ser His Met Gly Leu Ser Pro Lys Arg Glu 
    50                  55                  60                  


Thr Thr Ala Arg Lys Thr Arg Leu Leu Arg Ala Gly Glu Lys Lys Val 
65                  70                  75                  80  


Ser Gln Trp Ala 
                


<210>  5
<211>  819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Consensus LEMD1AF DNA Sequence

<400>  5
atggactgga cctggattct gttcctggtg gcagcagcaa cccgcgtgca ttccgtcgat       60

gtgaagtgtc tgagtgattg taaactgcag aaccagctgg agaagctggc ctttagccct      120

ggagcaatcc tgccatccac caggaagctg gccgagaaga agctggtgca gctgctggtg      180

agcccacctt gcgcaccacc cgtgatgaat ggcccaagag agctggacgg cgcccaggat      240

agcgacgatt ccgaggagct gaacatcatc ctgcagggca atatcatcct gtctaccgag      300

aagagcaaga agctgaagaa gcggcccgag gcctccacca caaagcctaa ggccgtggac      360

acatactgcc tggattataa gccttccaag ggccggagat gggcagccag ggccccatct      420

accaggatca catacggcac catcacaaag gagcgggact attgtaccga ggatcagaca      480

gccgagtctt ggagagagga gggattccca gtgggcctga agctggccgt gctgggcatc      540

ttcatcatcg tggtgttcgt gtacctgaca gtggagaaca agcctctgtt tggccggggc      600

agaaagaggc gctctgtgga tgtaaaatgc ctatcggact gcaagttgca aaatcaatta      660

gaaaaattgg ccttctcccc aggggcgata ttgaggggcc tgcaggagca ccaggcacca      720

gagtcccaca tgggcctgtc tcccaagcgc gagacaaccg caagaaaaac aaggctgctg      780

agggctgggg aaaagaaagt gtcacagtgg gcatgataa                             819


<210>  6
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Consensus LEMD1AF Protein Sequence

<400>  6

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Val Asp Val Lys Cys Leu Ser Asp Cys Lys Leu Gln Asn Gln 
            20                  25                  30          


Leu Glu Lys Leu Ala Phe Ser Pro Gly Ala Ile Leu Pro Ser Thr Arg 
        35                  40                  45              


Lys Leu Ala Glu Lys Lys Leu Val Gln Leu Leu Val Ser Pro Pro Cys 
    50                  55                  60                  


Ala Pro Pro Val Met Asn Gly Pro Arg Glu Leu Asp Gly Ala Gln Asp 
65                  70                  75                  80  


Ser Asp Asp Ser Glu Glu Leu Asn Ile Ile Leu Gln Gly Asn Ile Ile 
                85                  90                  95      


Leu Ser Thr Glu Lys Ser Lys Lys Leu Lys Lys Arg Pro Glu Ala Ser 
            100                 105                 110         


Thr Thr Lys Pro Lys Ala Val Asp Thr Tyr Cys Leu Asp Tyr Lys Pro 
        115                 120                 125             


Ser Lys Gly Arg Arg Trp Ala Ala Arg Ala Pro Ser Thr Arg Ile Thr 
    130                 135                 140                 


Tyr Gly Thr Ile Thr Lys Glu Arg Asp Tyr Cys Thr Glu Asp Gln Thr 
145                 150                 155                 160 


Ala Glu Ser Trp Arg Glu Glu Gly Phe Pro Val Gly Leu Lys Leu Ala 
                165                 170                 175     


Val Leu Gly Ile Phe Ile Ile Val Val Phe Val Tyr Leu Thr Val Glu 
            180                 185                 190         


Asn Lys Pro Leu Phe Gly Arg Gly Arg Lys Arg Arg Ser Val Asp Val 
        195                 200                 205             


Lys Cys Leu Ser Asp Cys Lys Leu Gln Asn Gln Leu Glu Lys Leu Ala 
    210                 215                 220                 


Phe Ser Pro Gly Ala Ile Leu Arg Gly Leu Gln Glu His Gln Ala Pro 
225                 230                 235                 240 


Glu Ser His Met Gly Leu Ser Pro Lys Arg Glu Thr Thr Ala Arg Lys 
                245                 250                 255     


Thr Arg Leu Leu Arg Ala Gly Glu Lys Lys Val Ser Gln Trp Ala 
            260                 265                 270     


<210>  7
<211>  3554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX1431

<400>  7
gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccgccac catggactgg acctggattc tgttcctggt ggcagcagca      780

acacgggtgc actccgtgga cgtgaagtgc ctgtctgatt gtaagctgca gaaccagctg      840

gagaagctgg cctttagccc tggcgccatc ctgccatcca ccaggaagct ggccgagaag      900

aagctggtgc agctgctggt gtccccacct tgcgcaccac ccgtgatgaa tggaccccgc      960

gagctggacg gagcacagga tagcgacgat tccgaggagc tgaacatcat cctgcagggc     1020

aatatcatcc tgtctaccga gaagagcaag aagctgaaga agcggcccga ggcctctacc     1080

acaaagccta aggccgtgga cacatactgc ctggattata agccatctaa gggccggaga     1140

tgggcagcca gggccccaag cacccgcatc acatacggca ccatcacaaa ggagcgggac     1200

tattgtaccg aggatcagac agccgagagc tggagagagg agggcttccc tgtgggcctg     1260

aagctggccg tgctgggcat cttcatcatc gtggtgttcg tgtacctgac agtggagaac     1320

aagccactgt ttggctgata actcgagtct agagggcccg tttaaacccg ctgatcagcc     1380

tcgactgtgc cttctagttg ccagccatct gttgtttgcc cctcccccgt gccttccttg     1440

accctggaag gtgccactcc cactgtcctt tcctaataaa atgaggaaat tgcatcgcat     1500

tgtctgagta ggtgtcattc tattctgggg ggtggggtgg ggcaggacag caagggggag     1560

gattgggaag acaatagcag gcatgctggg gatgcggtgg gctctatggc ttctactggg     1620

cggttttatg gacagcaagc gaaccggaat tgccagctgg ggcgccctct ggtaaggttg     1680

ggaagccctg caaagtaaac tggatggctt tcttgccgcc aaggatctga tggcgcaggg     1740

gatcaagctc tgatcaagag acaggatgag gatcgtttcg catgattgaa caagatggat     1800

tgcacgcagg ttctccggcc gcttgggtgg agaggctatt cggctatgac tgggcacaac     1860

agacaatcgg ctgctctgat gccgccgtgt tccggctgtc agcgcagggg cgcccggttc     1920

tttttgtcaa gaccgacctg tccggtgccc tgaatgaact gcaagacgag gcagcgcggc     1980

tatcgtggct ggccacgacg ggcgttcctt gcgcagctgt gctcgacgtt gtcactgaag     2040

cgggaaggga ctggctgcta ttgggcgaag tgccggggca ggatctcctg tcatctcacc     2100

ttgctcctgc cgagaaagta tccatcatgg ctgatgcaat gcggcggctg catacgcttg     2160

atccggctac ctgcccattc gaccaccaag cgaaacatcg catcgagcga gcacgtactc     2220

ggatggaagc cggtcttgtc gatcaggatg atctggacga agagcatcag gggctcgcgc     2280

cagccgaact gttcgccagg ctcaaggcga gcatgcccga cggcgaggat ctcgtcgtga     2340

cccatggcga tgcctgcttg ccgaatatca tggtggaaaa tggccgcttt tctggattca     2400

tcgactgtgg ccggctgggt gtggcggacc gctatcagga catagcgttg gctacccgtg     2460

atattgctga agagcttggc ggcgaatggg ctgaccgctt cctcgtgctt tacggtatcg     2520

ccgctcccga ttcgcagcgc atcgccttct atcgccttct tgacgagttc ttctgaatta     2580

ttaacgctta caatttcctg atgcggtatt ttctccttac gcatctgtgc ggtatttcac     2640

accgcatcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc     2700

taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa     2760

tagcacgtgc taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat     2820

aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta     2880

gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa     2940

acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt     3000

tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag     3060

ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta     3120

atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca     3180

agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag     3240

cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa     3300

agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga     3360

acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc     3420

gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc     3480

ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt     3540

gctcacatgt tctt                                                       3554


<210>  8
<211>  3212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX1432

<400>  8
gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccgccac catggactgg acctggattc tgttcctggt ggcagcagca      780

acaagggtgc actctgtgga cgtgaagtgc ctgagcgatt gtaagctgca gaaccagctg      840

gagaagctgg ccttttcccc aggagcaatc ctgaggggac tgcaggagca ccaggcacca      900

gagagccaca tgggactgtc ccctaagcgg gagaccacag caaggaagac cagactgctg      960

agggcaggag agaagaaggt gtctcagtgg gcctgataac tcgagtctag agggcccgtt     1020

taaacccgct gatcagcctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc     1080

tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat     1140

gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg     1200

caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc     1260

tctatggctt ctactgggcg gttttatgga cagcaagcga accggaattg ccagctgggg     1320

cgccctctgg taaggttggg aagccctgca aagtaaactg gatggctttc ttgccgccaa     1380

ggatctgatg gcgcagggga tcaagctctg atcaagagac aggatgagga tcgtttcgca     1440

tgattgaaca agatggattg cacgcaggtt ctccggccgc ttgggtggag aggctattcg     1500

gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag     1560

cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactgc     1620

aagacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc     1680

tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg     1740

atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct gatgcaatgc     1800

ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca     1860

tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag     1920

agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgagc atgcccgacg     1980

gcgaggatct cgtcgtgacc catggcgatg cctgcttgcc gaatatcatg gtggaaaatg     2040

gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca     2100

tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc     2160

tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat cgccttcttg     2220

acgagttctt ctgaattatt aacgcttaca atttcctgat gcggtatttt ctccttacgc     2280

atctgtgcgg tatttcacac cgcatcaggt ggcacttttc ggggaaatgt gcgcggaacc     2340

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc     2400

tgataaatgc ttcaataata gcacgtgcta aaacttcatt tttaatttaa aaggatctag     2460

gtgaagatcc tttttgataa tctcatgacc aaaatccctt aacgtgagtt ttcgttccac     2520

tgagcgtcag accccgtaga aaagatcaaa ggatcttctt gagatccttt ttttctgcgc     2580

gtaatctgct gcttgcaaac aaaaaaacca ccgctaccag cggtggtttg tttgccggat     2640

caagagctac caactctttt tccgaaggta actggcttca gcagagcgca gataccaaat     2700

actgttcttc tagtgtagcc gtagttaggc caccacttca agaactctgt agcaccgcct     2760

acatacctcg ctctgctaat cctgttacca gtggctgctg ccagtggcga taagtcgtgt     2820

cttaccgggt tggactcaag acgatagtta ccggataagg cgcagcggtc gggctgaacg     2880

gggggttcgt gcacacagcc cagcttggag cgaacgacct acaccgaact gagataccta     2940

cagcgtgagc tatgagaaag cgccacgctt cccgaaggga gaaaggcgga caggtatccg     3000

gtaagcggca gggtcggaac aggagagcgc acgagggagc ttccaggggg aaacgcctgg     3060

tatctttata gtcctgtcgg gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc     3120

tcgtcagggg ggcggagcct atggaaaaac gccagcaacg cggccttttt acggttcctg     3180

gccttttgct ggccttttgc tcacatgttc tt                                   3212


<210>  9
<211>  3773
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGX1433

<400>  9
gctgcttcgc gatgtacggg ccagatatac gcgttgacat tgattattga ctagttatta       60

atagtaatca attacggggt cattagttca tagcccatat atggagttcc gcgttacata      120

acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat tgacgtcaat      180

aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc aatgggtgga      240

gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc caagtacgcc      300

ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt acatgacctt      360

atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta ccatggtgat      420

gcggttttgg cagtacatca atgggcgtgg atagcggttt gactcacggg gatttccaag      480

tctccacccc attgacgtca atgggagttt gttttggcac caaaatcaac gggactttcc      540

aaaatgtcgt aacaactccg ccccattgac gcaaatgggc ggtaggcgtg tacggtggga      600

ggtctatata agcagagctc tctggctaac tagagaaccc actgcttact ggcttatcga      660

aattaatacg actcactata gggagaccca agctggctag cgtttaaact taagcttggt      720

accgagctcg gatccgccac catggactgg acctggattc tgttcctggt ggcagcagca      780

acccgcgtgc attccgtcga tgtgaagtgt ctgagtgatt gtaaactgca gaaccagctg      840

gagaagctgg cctttagccc tggagcaatc ctgccatcca ccaggaagct ggccgagaag      900

aagctggtgc agctgctggt gagcccacct tgcgcaccac ccgtgatgaa tggcccaaga      960

gagctggacg gcgcccagga tagcgacgat tccgaggagc tgaacatcat cctgcagggc     1020

aatatcatcc tgtctaccga gaagagcaag aagctgaaga agcggcccga ggcctccacc     1080

acaaagccta aggccgtgga cacatactgc ctggattata agccttccaa gggccggaga     1140

tgggcagcca gggccccatc taccaggatc acatacggca ccatcacaaa ggagcgggac     1200

tattgtaccg aggatcagac agccgagtct tggagagagg agggattccc agtgggcctg     1260

aagctggccg tgctgggcat cttcatcatc gtggtgttcg tgtacctgac agtggagaac     1320

aagcctctgt ttggccgggg cagaaagagg cgctctgtgg atgtaaaatg cctatcggac     1380

tgcaagttgc aaaatcaatt agaaaaattg gccttctccc caggggcgat attgaggggc     1440

ctgcaggagc accaggcacc agagtcccac atgggcctgt ctcccaagcg cgagacaacc     1500

gcaagaaaaa caaggctgct gagggctggg gaaaagaaag tgtcacagtg ggcatgataa     1560

ctcgagtcta gagggcccgt ttaaacccgc tgatcagcct cgactgtgcc ttctagttgc     1620

cagccatctg ttgtttgccc ctcccccgtg ccttccttga ccctggaagg tgccactccc     1680

actgtccttt cctaataaaa tgaggaaatt gcatcgcatt gtctgagtag gtgtcattct     1740

attctggggg gtggggtggg gcaggacagc aagggggagg attgggaaga caatagcagg     1800

catgctgggg atgcggtggg ctctatggct tctactgggc ggttttatgg acagcaagcg     1860

aaccggaatt gccagctggg gcgccctctg gtaaggttgg gaagccctgc aaagtaaact     1920

ggatggcttt cttgccgcca aggatctgat ggcgcagggg atcaagctct gatcaagaga     1980

caggatgagg atcgtttcgc atgattgaac aagatggatt gcacgcaggt tctccggccg     2040

cttgggtgga gaggctattc ggctatgact gggcacaaca gacaatcggc tgctctgatg     2100

ccgccgtgtt ccggctgtca gcgcaggggc gcccggttct ttttgtcaag accgacctgt     2160

ccggtgccct gaatgaactg caagacgagg cagcgcggct atcgtggctg gccacgacgg     2220

gcgttccttg cgcagctgtg ctcgacgttg tcactgaagc gggaagggac tggctgctat     2280

tgggcgaagt gccggggcag gatctcctgt catctcacct tgctcctgcc gagaaagtat     2340

ccatcatggc tgatgcaatg cggcggctgc atacgcttga tccggctacc tgcccattcg     2400

accaccaagc gaaacatcgc atcgagcgag cacgtactcg gatggaagcc ggtcttgtcg     2460

atcaggatga tctggacgaa gagcatcagg ggctcgcgcc agccgaactg ttcgccaggc     2520

tcaaggcgag catgcccgac ggcgaggatc tcgtcgtgac ccatggcgat gcctgcttgc     2580

cgaatatcat ggtggaaaat ggccgctttt ctggattcat cgactgtggc cggctgggtg     2640

tggcggaccg ctatcaggac atagcgttgg ctacccgtga tattgctgaa gagcttggcg     2700

gcgaatgggc tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat tcgcagcgca     2760

tcgccttcta tcgccttctt gacgagttct tctgaattat taacgcttac aatttcctga     2820

tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatcagg tggcactttt     2880

cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat     2940

ccgctcatga gacaataacc ctgataaatg cttcaataat agcacgtgct aaaacttcat     3000

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     3060

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     3120

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     3180

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     3240

agcagagcgc agataccaaa tactgttctt ctagtgtagc cgtagttagg ccaccacttc     3300

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     3360

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     3420

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     3480

tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg     3540

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     3600

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     3660

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     3720

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctt            3773


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Furin cleavage site

<400>  10

Arg Gly Arg Lys Arg Arg Ser 
1               5           


<210>  11
<211>  198
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Native Human LEMD1A Protein Sequence

<400>  11

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Val Asp Val Lys Cys Leu Ser Asp Cys Lys Leu Gln Asn Gln 
            20                  25                  30          


Leu Glu Lys Leu Gly Phe Ser Pro Gly Pro Ile Leu Pro Ser Thr Arg 
        35                  40                  45              


Lys Leu Tyr Glu Lys Lys Leu Val Gln Leu Leu Val Ser Pro Pro Cys 
    50                  55                  60                  


Ala Pro Pro Val Met Asn Gly Pro Arg Glu Leu Asp Gly Ala Gln Asp 
65                  70                  75                  80  


Ser Asp Asp Ser Glu Glu Leu Asn Ile Ile Leu Gln Gly Asn Ile Ile 
                85                  90                  95      


Leu Ser Thr Glu Lys Ser Lys Lys Leu Lys Lys Trp Pro Glu Ala Ser 
            100                 105                 110         


Thr Thr Lys Arg Lys Ala Val Asp Thr Tyr Cys Leu Asp Tyr Lys Pro 
        115                 120                 125             


Ser Lys Gly Arg Arg Trp Ala Ala Arg Ala Pro Ser Thr Arg Ile Thr 
    130                 135                 140                 


Tyr Gly Thr Ile Thr Lys Glu Arg Asp Tyr Cys Ala Glu Asp Gln Thr 
145                 150                 155                 160 


Ile Glu Ser Trp Arg Glu Glu Gly Phe Pro Val Gly Leu Lys Leu Ala 
                165                 170                 175     


Val Leu Gly Ile Phe Ile Ile Val Val Phe Val Tyr Leu Thr Val Glu 
            180                 185                 190         


Asn Lys Ser Leu Phe Gly 
        195             


<210>  12
<211>  84
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Native Human LEMD1F Protein Sequence

<400>  12

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Val Asp Val Lys Cys Leu Ser Asp Cys Lys Leu Gln Asn Gln 
            20                  25                  30          


Leu Glu Lys Leu Gly Phe Ser Pro Gly Pro Ile Leu Arg Gly Leu Gln 
        35                  40                  45              


Glu His Gln Ala Pro Glu Ser His Met Gly Leu Ser Pro Lys Arg Glu 
    50                  55                  60                  


Thr Thr Ala Arg Lys Thr Arg Leu Ser Arg Ala Gly Glu Lys Lys Val 
65                  70                  75                  80  


Ser Gln Trp Ala 
                


