                         SEQUENCE LISTING

<110>  INOVIO PHARMACEUTICALS, INC
       YAN, Jian
       SLAGER, Anna
       GARMAN, Bradley
       COOCH, Neil
 
<120>  CANCER VACCINES TARGETING PRAME AND USES THEREOF

<130>  INO-1003WO / 104409.000445

<150>  US 62/598,290
<151>  2017-12-13

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  1584
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Consensus PRAME DNA Coding Sequence pGX1421

<400>  1
atggactgga catggattct gttcctggtc gctgctgcta cacgggtgca ttcagagaga       60

cgaagactgc ggggctcaat tcagagtagg tacatcagta tgtcagtctg gacctcacca      120

cggagactgg tggaactggc cgggcagagc ctgctgaagg atgaggccct ggctattgcc      180

gctctggaac tgctgccccg agagctgttc cctcccctgt tcatggcagc cttcgacgga      240

cgccacagcc agactctgaa ggctatggtc caggcatggc cctttacctg cctgcctctg      300

ggcgtgctga tgaaggggca gcagctgcat ctggagactt tcaaagcagt gctggatggc      360

ctggacgtgc tgctggccca ggaagtgagg cctaggcgct ggaagctgga ggtcctggat      420

ctgcgcaaaa acagccacca ggacttttgg accgtgtggt ccgggaatcg ggccagtctg      480

tactcattcc cagaacccga ggctgcacag ccaatgcgga agaaaagaaa ggtggatgga      540

ctgtccaccg aagctgagca gccttttaca ccaatcgaag tgctggtcga tctgtccctg      600

aaagaaggcg catgcgacga gctgttctct tatctgatgg agaaggtcaa aagacagaag      660

aacgtgctgc acctgtgctg taagaaactg aaaatctttg ctatgcccat gcaggacatc      720

aagatgattc tgaaaatggt ccagctggat tccattgaag acctggaggt cacttgtacc      780

tggaagctgc caacactggc caaattctct ccctacctgg gacagatgat caatctgcga      840

cggctgctgc tgtctcacat ccatgctagc tcctctatta gtcctgagaa ggaggaagag      900

tacattgcac agtttacttc tcagttcctg agtctgcagt gcctgcaggc cctgtatgtg      960

gatagcctgt tctttctgag aggcaggctg gaccagctgc tgcgacacgt catgaacccc     1020

ctggaaacac tgagtgtgac taattgtaga ctgtcagagg gcgatgtgat gcatctgagc     1080

cagtccccta acgtgagcca gctgtccgtc ctgtctctga gtggcgtgat gctgacagac     1140

gtgagccctg aaccactgca ggccctgctg gagcgagcat ctgccactct gcaggacctg     1200

gattttgacg agtgtgggat catggacgat cagctgctgg tgctgctgcc ttcactgagc     1260

cactgctccc agctgaccac actgtctttc tgtgggaacc caatctccat ttctgtgctg     1320

cagaatctgc tgcaccatct gattggactg agcaacctga cccatgtgct gtaccccgtc     1380

cctctggaaa gctatgagga tgtgcacgga acactgcatc tgggcaggct ggcctatctg     1440

cacgctcgcc tgcgagaagt ggtgtgcgag ctgggcagac cctcaatggt gtggctgagc     1500

gccaatccat gtccccattg cggcgaccgg acattctacg accccgaacc tattctgtgc     1560

ccctgcttca tgcctaactg ataa                                            1584


<210>  2
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Consensus PRAME Protein Coding Sequence pGX1421

<400>  2

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Glu Arg Arg Arg Leu Arg Gly Ser Ile Gln Ser Arg Tyr Ile 
            20                  25                  30          


Ser Met Ser Val Trp Thr Ser Pro Arg Arg Leu Val Glu Leu Ala Gly 
        35                  40                  45              


Gln Ser Leu Leu Lys Asp Glu Ala Leu Ala Ile Ala Ala Leu Glu Leu 
    50                  55                  60                  


Leu Pro Arg Glu Leu Phe Pro Pro Leu Phe Met Ala Ala Phe Asp Gly 
65                  70                  75                  80  


Arg His Ser Gln Thr Leu Lys Ala Met Val Gln Ala Trp Pro Phe Thr 
                85                  90                  95      


Cys Leu Pro Leu Gly Val Leu Met Lys Gly Gln Gln Leu His Leu Glu 
            100                 105                 110         


Thr Phe Lys Ala Val Leu Asp Gly Leu Asp Val Leu Leu Ala Gln Glu 
        115                 120                 125             


Val Arg Pro Arg Arg Trp Lys Leu Glu Val Leu Asp Leu Arg Lys Asn 
    130                 135                 140                 


Ser His Gln Asp Phe Trp Thr Val Trp Ser Gly Asn Arg Ala Ser Leu 
145                 150                 155                 160 


Tyr Ser Phe Pro Glu Pro Glu Ala Ala Gln Pro Met Arg Lys Lys Arg 
                165                 170                 175     


Lys Val Asp Gly Leu Ser Thr Glu Ala Glu Gln Pro Phe Thr Pro Ile 
            180                 185                 190         


Glu Val Leu Val Asp Leu Ser Leu Lys Glu Gly Ala Cys Asp Glu Leu 
        195                 200                 205             


Phe Ser Tyr Leu Met Glu Lys Val Lys Arg Gln Lys Asn Val Leu His 
    210                 215                 220                 


Leu Cys Cys Lys Lys Leu Lys Ile Phe Ala Met Pro Met Gln Asp Ile 
225                 230                 235                 240 


Lys Met Ile Leu Lys Met Val Gln Leu Asp Ser Ile Glu Asp Leu Glu 
                245                 250                 255     


Val Thr Cys Thr Trp Lys Leu Pro Thr Leu Ala Lys Phe Ser Pro Tyr 
            260                 265                 270         


Leu Gly Gln Met Ile Asn Leu Arg Arg Leu Leu Leu Ser His Ile His 
        275                 280                 285             


Ala Ser Ser Ser Ile Ser Pro Glu Lys Glu Glu Glu Tyr Ile Ala Gln 
    290                 295                 300                 


Phe Thr Ser Gln Phe Leu Ser Leu Gln Cys Leu Gln Ala Leu Tyr Val 
305                 310                 315                 320 


Asp Ser Leu Phe Phe Leu Arg Gly Arg Leu Asp Gln Leu Leu Arg His 
                325                 330                 335     


Val Met Asn Pro Leu Glu Thr Leu Ser Val Thr Asn Cys Arg Leu Ser 
            340                 345                 350         


Glu Gly Asp Val Met His Leu Ser Gln Ser Pro Asn Val Ser Gln Leu 
        355                 360                 365             


Ser Val Leu Ser Leu Ser Gly Val Met Leu Thr Asp Val Ser Pro Glu 
    370                 375                 380                 


Pro Leu Gln Ala Leu Leu Glu Arg Ala Ser Ala Thr Leu Gln Asp Leu 
385                 390                 395                 400 


Asp Phe Asp Glu Cys Gly Ile Met Asp Asp Gln Leu Leu Val Leu Leu 
                405                 410                 415     


Pro Ser Leu Ser His Cys Ser Gln Leu Thr Thr Leu Ser Phe Cys Gly 
            420                 425                 430         


Asn Pro Ile Ser Ile Ser Val Leu Gln Asn Leu Leu His His Leu Ile 
        435                 440                 445             


Gly Leu Ser Asn Leu Thr His Val Leu Tyr Pro Val Pro Leu Glu Ser 
    450                 455                 460                 


Tyr Glu Asp Val His Gly Thr Leu His Leu Gly Arg Leu Ala Tyr Leu 
465                 470                 475                 480 


His Ala Arg Leu Arg Glu Val Val Cys Glu Leu Gly Arg Pro Ser Met 
                485                 490                 495     


Val Trp Leu Ser Ala Asn Pro Cys Pro His Cys Gly Asp Arg Thr Phe 
            500                 505                 510         


Tyr Asp Pro Glu Pro Ile Leu Cys Pro Cys Phe Met Pro Asn 
        515                 520                 525     


