                         SEQUENCE LISTING

<110>  SYNGENTA PARTICIPATIONS AG
       YARNELL, Michelle
       CHEVREL, Anne
       KITTEN, Olivier
       YOUNG, Scott
 
<120>  NON-ANTIBODY LIGANDS FOR DETECTING TARGET PROTEINS

<130>  81317-WO-REG-ORG-P-1

<150>  US 62/599,289
<151>  2017-12-15

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  615
<212>  PRT
<213>  Bacillus thuringiensis

<400>  1

Met Asp Asn Asn Pro Asn Ile Asn Glu Cys Ile Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Ser Asn Pro Glu Val Glu Val Leu Gly Gly Glu Arg Ile Glu Thr Gly 
            20                  25                  30          


Tyr Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Val Asp Ile Ile 
    50                  55                  60                  


Trp Gly Ile Phe Gly Pro Ser Gln Trp Asp Ala Phe Leu Val Gln Ile 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Glu Glu Phe Ala Arg Asn Gln Ala 
                85                  90                  95      


Ile Ser Arg Leu Glu Gly Leu Ser Asn Leu Tyr Gln Ile Tyr Ala Glu 
            100                 105                 110         


Ser Phe Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Arg Glu 
        115                 120                 125             


Glu Met Arg Ile Gln Phe Asn Asp Met Asn Ser Ala Leu Thr Thr Ala 
    130                 135                 140                 


Ile Pro Leu Phe Ala Val Gln Asn Tyr Gln Val Pro Leu Leu Ser Val 
145                 150                 155                 160 


Tyr Val Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser 
                165                 170                 175     


Val Phe Gly Gln Arg Trp Gly Phe Asp Ala Ala Thr Ile Asn Ser Arg 
            180                 185                 190         


Tyr Asn Asp Leu Thr Arg Leu Ile Gly Asn Tyr Thr Asp His Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Ile Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ser Leu Phe Pro Asn Tyr Asp Ser Arg Thr Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Ser Ala Gln Gly Ile Glu 
        275                 280                 285             


Gly Ser Ile Arg Ser Pro His Leu Met Asp Ile Leu Asn Ser Ile Thr 
    290                 295                 300                 


Ile Tyr Thr Asp Ala His Arg Gly Glu Tyr Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Met Ala Ser Pro Val Gly Phe Ser Gly Pro Glu Phe Thr Phe Pro 
                325                 330                 335     


Leu Tyr Gly Thr Met Gly Asn Ala Ala Pro Gln Gln Arg Ile Val Ala 
            340                 345                 350         


Gln Leu Gly Gln Gly Val Tyr Arg Thr Leu Ser Ser Thr Leu Tyr Arg 
        355                 360                 365             


Arg Pro Phe Asn Ile Gly Ile Asn Asn Gln Gln Leu Ser Val Leu Asp 
    370                 375                 380                 


Gly Thr Glu Phe Ala Tyr Gly Thr Ser Ser Asn Leu Pro Ser Ala Val 
385                 390                 395                 400 


Tyr Arg Lys Ser Gly Thr Val Asp Ser Leu Asp Glu Ile Pro Pro Gln 
                405                 410                 415     


Asn Asn Asn Val Pro Pro Arg Gln Gly Phe Ser His Arg Leu Ser His 
            420                 425                 430         


Val Ser Met Phe Arg Ser Gly Phe Ser Asn Ser Ser Val Ser Ile Ile 
        435                 440                 445             


Arg Ala Pro Met Phe Ser Trp Ile His Arg Ser Ala Glu Phe Asn Asn 
    450                 455                 460                 


Ile Ile Pro Ser Ser Gln Ile Thr Gln Ile Pro Leu Thr Lys Ser Thr 
465                 470                 475                 480 


Asn Leu Gly Ser Gly Thr Ser Val Val Lys Gly Pro Gly Phe Thr Gly 
                485                 490                 495     


Gly Asp Ile Leu Arg Arg Thr Ser Pro Gly Gln Ile Ser Thr Leu Arg 
            500                 505                 510         


Val Asn Ile Thr Ala Pro Leu Ser Gln Arg Tyr Arg Val Arg Ile Arg 
        515                 520                 525             


Tyr Ala Ser Thr Thr Asn Leu Gln Phe His Thr Ser Ile Asp Gly Arg 
    530                 535                 540                 


Pro Ile Asn Gln Gly Asn Phe Ser Ala Thr Met Ser Ser Gly Ser Asn 
545                 550                 555                 560 


Leu Gln Ser Gly Ser Phe Arg Thr Val Gly Phe Thr Thr Pro Phe Asn 
                565                 570                 575     


Phe Ser Asn Gly Ser Ser Val Phe Thr Leu Ser Ala His Val Phe Asn 
            580                 585                 590         


Ser Gly Asn Glu Val Tyr Ile Asp Arg Ile Glu Phe Val Pro Ala Glu 
        595                 600                 605             


Val Thr Phe Glu Ala Glu Tyr 
    610                 615 


<210>  2
<211>  653
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hybrid toxin.

<400>  2

Met Thr Ser Asn Gly Arg Gln Cys Ala Gly Ile Arg Pro Tyr Asp Gly 
1               5                   10                  15      


Arg Gln Gln His Arg Gly Leu Asp Ser Ser Thr Thr Lys Asp Val Ile 
            20                  25                  30          


Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val Val Gly Phe 
        35                  40                  45              


Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe Leu Asn Thr 
    50                  55                  60                  


Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu Gln Val Glu 
65                  70                  75                  80  


Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn Lys Ala Leu 
                85                  90                  95      


Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr Val Ser Ala 
            100                 105                 110         


Leu Ser Ser Trp Gln Lys Asn Pro Ala Ala Pro Phe Arg Asn Pro His 
        115                 120                 125             


Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu Ser His Phe 
    130                 135                 140                 


Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu Val Leu Phe 
145                 150                 155                 160 


Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe Leu Leu Lys 
                165                 170                 175     


Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys Glu Asp Ile 
            180                 185                 190         


Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu Tyr Thr Asp 
        195                 200                 205             


His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu Arg Gly Ser 
    210                 215                 220                 


Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg Glu Met Thr 
225                 230                 235                 240 


Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr Asp Val Arg 
                245                 250                 255     


Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp Val Leu Thr 
            260                 265                 270         


Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gly Tyr Gly Thr Thr Phe 
        275                 280                 285             


Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe Asp Tyr Leu 
    290                 295                 300                 


His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr Tyr Gly Asn 
305                 310                 315                 320 


Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr Arg Pro Ser 
                325                 330                 335     


Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly Asn Lys Ser 
            340                 345                 350         


Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys Val Tyr Arg 
        355                 360                 365             


Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala Val Tyr Ser 
    370                 375                 380                 


Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln Thr Asp Glu 
385                 390                 395                 400 


Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly Ala Val Ser 
                405                 410                 415     


Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp Glu Pro Leu 
            420                 425                 430         


Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys Phe Leu Met 
        435                 440                 445             


Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr His Lys Ser 
    450                 455                 460                 


Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr Gln Leu Pro 
465                 470                 475                 480 


Leu Thr Lys Ser Thr Asn Leu Gly Ser Gly Thr Ser Val Val Lys Gly 
                485                 490                 495     


Pro Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser Pro Gly Gln 
            500                 505                 510         


Ile Ser Thr Leu Arg Val Asn Ile Thr Ala Pro Leu Ser Gln Arg Tyr 
        515                 520                 525             


Arg Val Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Gln Phe His Thr 
    530                 535                 540                 


Ser Ile Asp Gly Arg Pro Ile Asn Gln Gly Asn Phe Ser Ala Thr Met 
545                 550                 555                 560 


Ser Ser Gly Ser Asn Leu Gln Ser Gly Ser Phe Arg Thr Val Gly Phe 
                565                 570                 575     


Thr Thr Pro Phe Asn Phe Ser Asn Gly Ser Ser Val Phe Thr Leu Ser 
            580                 585                 590         


Ala His Val Phe Asn Ser Gly Asn Glu Val Tyr Ile Asp Arg Ile Glu 
        595                 600                 605             


Phe Val Pro Ala Glu Val Thr Phe Glu Ala Glu Tyr Asp Leu Glu Arg 
    610                 615                 620                 


Ala Gln Lys Ala Val Asn Glu Leu Phe Thr Ser Ser Asn Gln Ile Gly 
625                 630                 635                 640 


Leu Lys Thr Asp Val Thr Asp Tyr His Ile Asp Gln Val 
                645                 650             


<210>  3
<211>  598
<212>  PRT
<213>  Artificial Sequnece

<220>
<223>  modified Cry3A

<400>  3

Met Thr Ala Asp Asn Asn Thr Glu Ala Leu Asp Ser Ser Thr Thr Lys 
1               5                   10                  15      


Asp Val Ile Gln Lys Gly Ile Ser Val Val Gly Asp Leu Leu Gly Val 
            20                  25                  30          


Val Gly Phe Pro Phe Gly Gly Ala Leu Val Ser Phe Tyr Thr Asn Phe 
        35                  40                  45              


Leu Asn Thr Ile Trp Pro Ser Glu Asp Pro Trp Lys Ala Phe Met Glu 
    50                  55                  60                  


Gln Val Glu Ala Leu Met Asp Gln Lys Ile Ala Asp Tyr Ala Lys Asn 
65                  70                  75                  80  


Lys Ala Leu Ala Glu Leu Gln Gly Leu Gln Asn Asn Val Glu Asp Tyr 
                85                  90                  95      


Val Ser Ala Leu Ser Ser Trp Gln Lys Asn Pro Ala Ala Pro Phe Arg 
            100                 105                 110         


Asn Pro His Ser Gln Gly Arg Ile Arg Glu Leu Phe Ser Gln Ala Glu 
        115                 120                 125             


Ser His Phe Arg Asn Ser Met Pro Ser Phe Ala Ile Ser Gly Tyr Glu 
    130                 135                 140                 


Val Leu Phe Leu Thr Thr Tyr Ala Gln Ala Ala Asn Thr His Leu Phe 
145                 150                 155                 160 


Leu Leu Lys Asp Ala Gln Ile Tyr Gly Glu Glu Trp Gly Tyr Glu Lys 
                165                 170                 175     


Glu Asp Ile Ala Glu Phe Tyr Lys Arg Gln Leu Lys Leu Thr Gln Glu 
            180                 185                 190         


Tyr Thr Asp His Cys Val Lys Trp Tyr Asn Val Gly Leu Asp Lys Leu 
        195                 200                 205             


Arg Gly Ser Ser Tyr Glu Ser Trp Val Asn Phe Asn Arg Tyr Arg Arg 
    210                 215                 220                 


Glu Met Thr Leu Thr Val Leu Asp Leu Ile Ala Leu Phe Pro Leu Tyr 
225                 230                 235                 240 


Asp Val Arg Leu Tyr Pro Lys Glu Val Lys Thr Glu Leu Thr Arg Asp 
                245                 250                 255     


Val Leu Thr Asp Pro Ile Val Gly Val Asn Asn Leu Arg Gly Tyr Gly 
            260                 265                 270         


Thr Thr Phe Ser Asn Ile Glu Asn Tyr Ile Arg Lys Pro His Leu Phe 
        275                 280                 285             


Asp Tyr Leu His Arg Ile Gln Phe His Thr Arg Phe Gln Pro Gly Tyr 
    290                 295                 300                 


Tyr Gly Asn Asp Ser Phe Asn Tyr Trp Ser Gly Asn Tyr Val Ser Thr 
305                 310                 315                 320 


Arg Pro Ser Ile Gly Ser Asn Asp Ile Ile Thr Ser Pro Phe Tyr Gly 
                325                 330                 335     


Asn Lys Ser Ser Glu Pro Val Gln Asn Leu Glu Phe Asn Gly Glu Lys 
            340                 345                 350         


Val Tyr Arg Ala Val Ala Asn Thr Asn Leu Ala Val Trp Pro Ser Ala 
        355                 360                 365             


Val Tyr Ser Gly Val Thr Lys Val Glu Phe Ser Gln Tyr Asn Asp Gln 
    370                 375                 380                 


Thr Asp Glu Ala Ser Thr Gln Thr Tyr Asp Ser Lys Arg Asn Val Gly 
385                 390                 395                 400 


Ala Val Ser Trp Asp Ser Ile Asp Gln Leu Pro Pro Glu Thr Thr Asp 
                405                 410                 415     


Glu Pro Leu Glu Lys Gly Tyr Ser His Gln Leu Asn Tyr Val Met Cys 
            420                 425                 430         


Phe Leu Met Gln Gly Ser Arg Gly Thr Ile Pro Val Leu Thr Trp Thr 
        435                 440                 445             


His Lys Ser Val Asp Phe Phe Asn Met Ile Asp Ser Lys Lys Ile Thr 
    450                 455                 460                 


Gln Leu Pro Leu Val Lys Ala Tyr Lys Leu Gln Ser Gly Ala Ser Val 
465                 470                 475                 480 


Val Ala Gly Pro Arg Phe Thr Gly Gly Asp Ile Ile Gln Cys Thr Glu 
                485                 490                 495     


Asn Gly Ser Ala Ala Thr Ile Tyr Val Thr Pro Asp Val Ser Tyr Ser 
            500                 505                 510         


Gln Lys Tyr Arg Ala Arg Ile His Tyr Ala Ser Thr Ser Gln Ile Thr 
        515                 520                 525             


Phe Thr Leu Ser Leu Asp Gly Ala Pro Phe Asn Gln Tyr Tyr Phe Asp 
    530                 535                 540                 


Lys Thr Ile Asn Lys Gly Asp Thr Leu Thr Tyr Asn Ser Phe Asn Leu 
545                 550                 555                 560 


Ala Ser Phe Ser Thr Pro Phe Glu Leu Ser Gly Asn Asn Leu Gln Ile 
                565                 570                 575     


Gly Val Thr Gly Leu Ser Ala Gly Asp Lys Val Tyr Ile Asp Lys Ile 
            580                 585                 590         


Glu Phe Ile Pro Val Asn 
        595             


<210>  4
<211>  1176
<212>  PRT
<213>  Bacillus thuringiensis

<400>  4

Met Glu Ile Val Asn Asn Gln Asn Gln Cys Val Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Asn Asn Pro Glu Ile Glu Ile Leu Glu Gly Gly Arg Ile Ser Val Gly 
            20                  25                  30          


Asn Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Ile Asp Leu Ile 
    50                  55                  60                  


Trp Gly Phe Val Gly Pro Ser Gln Trp Asp Ala Phe Leu Ala Gln Val 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Ala Glu Ala Val Arg Asn Thr Ala 
                85                  90                  95      


Ile Gln Glu Leu Glu Gly Met Ala Arg Val Tyr Arg Thr Tyr Ala Thr 
            100                 105                 110         


Ala Phe Ala Glu Trp Glu Lys Ala Pro Asp Asp Pro Glu Leu Arg Glu 
        115                 120                 125             


Ala Leu Arg Thr Gln Phe Thr Ala Thr Glu Thr Tyr Ile Ser Gly Arg 
    130                 135                 140                 


Ile Ser Val Leu Lys Ile Gln Thr Phe Glu Val Gln Leu Leu Ser Val 
145                 150                 155                 160 


Phe Ala Gln Ala Ala Asn Leu His Leu Ser Leu Leu Arg Asp Val Val 
                165                 170                 175     


Phe Phe Gly Gln Arg Trp Gly Phe Ser Thr Thr Thr Val Asn Asn Tyr 
            180                 185                 190         


Tyr Asn Asp Leu Thr Glu Gly Ile Ser Thr Tyr Thr Asp Tyr Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Val Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ala Leu Phe Ser Asn Tyr Asp Ser Arg Arg Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Met Ala Gln Arg Ile Glu 
        275                 280                 285             


Gln Asn Ile Arg Gln Pro His Leu Met Asp Ile Leu Asn Ser Ile Thr 
    290                 295                 300                 


Ile Tyr Thr Asp Val His Arg Gly Phe Asn Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Thr Ala Ser Pro Val Gly Phe Ser Gly Pro Glu Phe Ala Phe Pro 
                325                 330                 335     


Leu Phe Gly Asn Ala Gly Asn Ala Ala Pro Pro Val Leu Val Ser Leu 
            340                 345                 350         


Thr Gly Leu Gly Ile Phe Arg Thr Leu Ser Ser Pro Leu Tyr Arg Arg 
        355                 360                 365             


Ile Ile Leu Gly Ser Gly Pro Asn Asn Gln Glu Leu Phe Val Leu Asp 
    370                 375                 380                 


Gly Thr Glu Phe Ser Phe Ala Ser Leu Thr Thr Asn Leu Pro Ser Thr 
385                 390                 395                 400 


Ile Tyr Arg Gln Arg Gly Thr Val Asp Ser Leu Asp Val Ile Pro Pro 
                405                 410                 415     


Gln Asp Asn Ser Val Pro Pro Arg Ala Gly Phe Ser His Arg Leu Ser 
            420                 425                 430         


His Val Thr Met Leu Ser Gln Ala Ala Gly Ala Val Tyr Thr Leu Arg 
        435                 440                 445             


Ala Pro Thr Phe Ser Trp Gln His Arg Ser Ala Glu Phe Asn Asn Ile 
    450                 455                 460                 


Ile Pro Ser Ser Gln Ile Thr Gln Ile Pro Leu Thr Lys Ser Thr Asn 
465                 470                 475                 480 


Leu Gly Ser Gly Thr Ser Val Val Lys Gly Pro Gly Phe Thr Gly Gly 
                485                 490                 495     


Asp Ile Leu Arg Arg Thr Ser Pro Gly Gln Ile Ser Thr Leu Arg Val 
            500                 505                 510         


Asn Ile Thr Ala Pro Leu Ser Gln Arg Tyr Arg Val Arg Ile Arg Tyr 
        515                 520                 525             


Ala Ser Thr Thr Asn Leu Gln Phe His Thr Ser Ile Asp Gly Arg Pro 
    530                 535                 540                 


Ile Asn Gln Gly Asn Phe Ser Ala Thr Met Ser Ser Gly Ser Asn Leu 
545                 550                 555                 560 


Gln Ser Gly Ser Phe Arg Thr Val Gly Phe Thr Thr Pro Phe Asn Phe 
                565                 570                 575     


Ser Asn Gly Ser Ser Val Phe Thr Leu Ser Ala His Val Phe Asn Ser 
            580                 585                 590         


Gly Asn Glu Val Tyr Ile Asp Arg Ile Glu Phe Val Pro Ala Glu Val 
        595                 600                 605             


Thr Phe Glu Ala Glu Tyr Asp Leu Glu Arg Ala Gln Lys Ala Val Asn 
    610                 615                 620                 


Glu Leu Phe Thr Ser Ser Asn Gln Ile Gly Leu Lys Thr Asp Val Thr 
625                 630                 635                 640 


Asp Tyr His Ile Asp Gln Val Ser Asn Leu Val Glu Cys Leu Ser Asp 
                645                 650                 655     


Glu Phe Cys Leu Asp Glu Lys Gln Glu Leu Ser Glu Lys Val Lys His 
            660                 665                 670         


Ala Lys Arg Leu Ser Asp Glu Arg Asn Leu Leu Gln Asp Pro Asn Phe 
        675                 680                 685             


Arg Gly Ile Asn Arg Gln Leu Asp Arg Gly Trp Arg Gly Ser Thr Asp 
    690                 695                 700                 


Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr Val Thr 
705                 710                 715                 720 


Leu Leu Gly Thr Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln Lys 
                725                 730                 735     


Ile Asp Glu Ser Lys Leu Lys Ala Tyr Thr Arg Tyr Gln Leu Arg Gly 
            740                 745                 750         


Tyr Ile Glu Asp Ser Gln Asp Leu Glu Ile Tyr Leu Ile Arg Tyr Asn 
        755                 760                 765             


Ala Lys His Glu Thr Val Asn Val Pro Gly Thr Gly Ser Leu Trp Pro 
    770                 775                 780                 


Leu Ser Ala Gln Ser Pro Ile Gly Lys Cys Gly Glu Pro Asn Arg Cys 
785                 790                 795                 800 


Ala Pro His Leu Glu Trp Asn Pro Asp Leu Asp Cys Ser Cys Arg Asp 
                805                 810                 815     


Gly Glu Lys Cys Ala His His Ser His His Phe Ser Leu Asp Ile Asp 
            820                 825                 830         


Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly Val Trp Val Ile Phe 
        835                 840                 845             


Lys Ile Lys Thr Gln Asp Gly His Ala Arg Leu Gly Asn Leu Glu Phe 
    850                 855                 860                 


Leu Glu Glu Lys Pro Leu Val Gly Glu Ala Leu Ala Arg Val Lys Ile 
865                 870                 875                 880 


Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp Glu Thr 
                885                 890                 895     


Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val Asp Ala Leu Phe Val 
            900                 905                 910         


Asn Ser Gln Tyr Asp Gln Leu Gln Ala Asp Thr Asn Ile Ala Met Ile 
        915                 920                 925             


His Ala Ala Asp Lys Arg Val His Ser Ile Arg Glu Ala Tyr Leu Pro 
    930                 935                 940                 


Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala Ile Phe Glu Glu Leu 
945                 950                 955                 960 


Glu Gly Arg Ile Phe Thr Ala Phe Ser Leu Tyr Asp Ala Arg Asn Val 
                965                 970                 975     


Ile Lys Asn Gly Asp Phe Asn Asn Gly Leu Ser Cys Trp Asn Val Lys 
            980                 985                 990         


Gly His Val Asp Val Glu Glu Gln  Asn Asn Gln Arg Ser  Val Leu Val 
        995                 1000                 1005             


Val Pro  Glu Trp Glu Ala Glu  Val Ser Gln Glu Val  Arg Val Cys 
    1010                 1015                 1020             


Pro Gly  Arg Gly Tyr Ile Leu  Arg Val Thr Ala Tyr  Lys Glu Gly 
    1025                 1030                 1035             


Tyr Gly  Glu Gly Cys Val Thr  Ile His Glu Ile Glu  Asn Asn Thr 
    1040                 1045                 1050             


Asp Glu  Leu Lys Phe Ser Asn  Cys Val Glu Glu Glu  Ile Tyr Ser 
    1055                 1060                 1065             


Asn Asn  Thr Val Thr Cys Asn  Asp Tyr Thr Val Asn  Gln Glu Glu 
    1070                 1075                 1080             


Tyr Gly  Gly Ala Tyr Thr Ser  Arg Asn Arg Gly Tyr  Asn Glu Ala 
    1085                 1090                 1095             


Pro Ser  Val Pro Ala Asp Tyr  Ala Ser Val Tyr Glu  Glu Lys Ser 
    1100                 1105                 1110             


Tyr Thr  Asp Gly Arg Arg Glu  Asn Pro Cys Glu Phe  Asn Arg Gly 
    1115                 1120                 1125             


Tyr Arg  Asp Tyr Thr Pro Leu  Pro Val Gly Tyr Val  Thr Lys Glu 
    1130                 1135                 1140             


Leu Glu  Tyr Phe Pro Glu Thr  Asp Lys Val Trp Ile  Glu Ile Gly 
    1145                 1150                 1155             


Glu Thr  Glu Gly Thr Phe Ile  Val Asp Ser Val Glu  Leu Leu Leu 
    1160                 1165                 1170             


Met Glu  Glu 
    1175     


<210>  5
<211>  1181
<212>  PRT
<213>  Bacillus thuringiensis

<400>  5

Met Asp Asn Asn Pro Asn Ile Asn Glu Cys Ile Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Ser Asn Pro Glu Val Glu Val Leu Gly Gly Glu Arg Ile Glu Thr Gly 
            20                  25                  30          


Tyr Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Val Asp Ile Ile 
    50                  55                  60                  


Trp Gly Ile Phe Gly Pro Ser Gln Trp Asp Ala Phe Leu Val Gln Ile 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Glu Glu Phe Ala Arg Asn Gln Ala 
                85                  90                  95      


Ile Ser Arg Leu Glu Gly Leu Ser Asn Leu Tyr Gln Ile Tyr Ala Glu 
            100                 105                 110         


Ser Phe Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Arg Glu 
        115                 120                 125             


Glu Met Arg Ile Gln Phe Asn Asp Met Asn Ser Ala Leu Thr Thr Ala 
    130                 135                 140                 


Ile Pro Leu Phe Ala Val Gln Asn Tyr Gln Val Pro Leu Leu Ser Val 
145                 150                 155                 160 


Tyr Val Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser 
                165                 170                 175     


Val Phe Gly Gln Arg Trp Gly Phe Asp Ala Ala Thr Ile Asn Ser Arg 
            180                 185                 190         


Tyr Asn Asp Leu Thr Arg Leu Ile Gly Asn Tyr Thr Asp Tyr Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Val Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ala Leu Phe Ser Asn Tyr Asp Ser Arg Arg Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Met Ala Gln Arg Ile Glu 
        275                 280                 285             


Gln Asn Ile Arg Gln Pro His Leu Met Asp Ile Leu Asn Ser Ile Thr 
    290                 295                 300                 


Ile Tyr Thr Asp Val His Arg Gly Phe Asn Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Thr Ala Ser Pro Val Gly Phe Ser Gly Pro Glu Phe Ala Phe Pro 
                325                 330                 335     


Leu Phe Gly Asn Ala Gly Asn Ala Ala Pro Pro Val Leu Val Ser Leu 
            340                 345                 350         


Thr Gly Leu Gly Ile Phe Arg Thr Leu Ser Ser Pro Leu Tyr Arg Arg 
        355                 360                 365             


Ile Ile Leu Gly Ser Gly Pro Asn Asn Gln Glu Leu Phe Val Leu Asp 
    370                 375                 380                 


Gly Thr Glu Phe Ser Phe Ala Ser Leu Thr Thr Asn Leu Pro Ser Thr 
385                 390                 395                 400 


Ile Tyr Arg Gln Arg Gly Thr Val Asp Ser Leu Asp Val Ile Pro Pro 
                405                 410                 415     


Gln Asp Asn Ser Val Pro Pro Arg Ala Gly Phe Ser His Arg Leu Ser 
            420                 425                 430         


His Val Thr Met Leu Ser Gln Ala Ala Gly Ala Val Tyr Thr Leu Arg 
        435                 440                 445             


Ala Pro Thr Phe Ser Trp Gln His Arg Ser Ala Glu Phe Asn Asn Ile 
    450                 455                 460                 


Ile Ala Ser Asp Ser Ile Thr Gln Ile Pro Ala Val Lys Gly Asn Phe 
465                 470                 475                 480 


Leu Phe Asn Gly Ser Val Ile Ser Gly Pro Gly Phe Thr Gly Gly Asp 
                485                 490                 495     


Leu Val Arg Leu Asn Ser Ser Gly Asn Asn Ile Gln Asn Arg Gly Tyr 
            500                 505                 510         


Ile Glu Val Pro Ile His Phe Pro Ser Thr Ser Thr Arg Tyr Arg Val 
        515                 520                 525             


Arg Val Arg Tyr Ala Ser Val Thr Pro Ile His Leu Asn Val Asn Trp 
    530                 535                 540                 


Gly Asn Ser Ser Ile Phe Ser Asn Thr Val Pro Ala Thr Ala Thr Ser 
545                 550                 555                 560 


Leu Asp Asn Leu Gln Ser Ser Asp Phe Gly Tyr Phe Glu Ser Ala Asn 
                565                 570                 575     


Ala Phe Thr Ser Ser Leu Gly Asn Ile Val Gly Val Arg Asn Phe Ser 
            580                 585                 590         


Gly Thr Ala Gly Val Ile Ile Asp Arg Phe Glu Phe Ile Pro Val Thr 
        595                 600                 605             


Ala Thr Leu Glu Ala Glu Tyr Asn Leu Glu Arg Ala Gln Lys Ala Val 
    610                 615                 620                 


Asn Ala Leu Phe Thr Ser Thr Asn Gln Leu Gly Leu Lys Thr Asn Val 
625                 630                 635                 640 


Thr Asp Tyr His Ile Asp Gln Val Ser Asn Leu Val Thr Cys Leu Ser 
                645                 650                 655     


Asp Glu Phe Cys Leu Asp Glu Lys Arg Glu Leu Ser Glu Lys Val Lys 
            660                 665                 670         


His Ala Lys Arg Leu Ser Asp Glu Arg Asn Leu Leu Gln Asp Ser Asn 
        675                 680                 685             


Phe Lys Asp Ile Asn Arg Gln Pro Glu Arg Gly Trp Gly Gly Ser Thr 
    690                 695                 700                 


Gly Ile Thr Ile Gln Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr Val 
705                 710                 715                 720 


Thr Leu Ser Gly Thr Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln 
                725                 730                 735     


Lys Ile Asp Glu Ser Lys Leu Lys Ala Phe Thr Arg Tyr Gln Leu Arg 
            740                 745                 750         


Gly Tyr Ile Glu Asp Ser Gln Asp Leu Glu Val Tyr Leu Ile Arg Tyr 
        755                 760                 765             


Asn Ala Lys His Glu Thr Leu Asn Val Pro Gly Thr Gly Ser Leu Trp 
    770                 775                 780                 


Pro Leu Ala Val Lys Ser Pro Ile Gly Arg Cys Gly Glu Pro Asn Arg 
785                 790                 795                 800 


Cys Ala Pro Arg Ile Glu Trp Lys Pro Asp Val Asp Cys Ser Cys Arg 
                805                 810                 815     


Asp Gly Glu Lys Cys Ala His His Ser His His Phe Ser Leu Asp Ile 
            820                 825                 830         


Asp Val Gly Cys Thr Asp Leu Asn Glu Asp Leu Gly Val Trp Val Ile 
        835                 840                 845             


Phe Lys Ile Lys Thr Gln Asp Gly His Ala Lys Ile Gly Asn Leu Glu 
    850                 855                 860                 


Phe Leu Glu Glu Lys Leu Leu Leu Gly Glu Ala Leu Ala Arg Val Lys 
865                 870                 875                 880 


Lys Ala Glu Lys Lys Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp Glu 
                885                 890                 895     


Thr Asn Ile Val Tyr Lys Glu Ala Lys Glu Ser Val Asp Ala Leu Phe 
            900                 905                 910         


Val Asp Ser Gln Tyr Asn Arg Leu Gln Thr Asp Thr Asn Ile Ala Met 
        915                 920                 925             


Ile His Ala Ala Asp Lys Arg Val His Arg Ile Arg Glu Ala Tyr Leu 
    930                 935                 940                 


Pro Glu Leu Ser Val Ile Pro Gly Val Asn Ala Ala Ile Phe Glu Glu 
945                 950                 955                 960 


Leu Glu Gly Leu Ile Phe Thr Ala Phe Ser Leu Tyr Asp Ala Arg Asn 
                965                 970                 975     


Val Ile Lys Asn Gly Asp Phe Asn Tyr Gly Leu Ser Cys Trp Asn Val 
            980                 985                 990         


Lys Gly His Val Asp Val Glu Glu  Gln Asn Asn His Arg  Ser Val Leu 
        995                 1000                 1005             


Val Ile  Pro Glu Trp Glu Ala  Glu Val Ser Gln Glu  Val Arg Val 
    1010                 1015                 1020             


Cys Pro  Gly Arg Gly Tyr Ile  Leu Arg Val Thr Ala  Tyr Lys Glu 
    1025                 1030                 1035             


Gly Tyr  Gly Glu Gly Cys Val  Thr Ile His Glu Ile  Glu Asp Asn 
    1040                 1045                 1050             


Thr Asp  Glu Leu Lys Phe Ser  Asn Cys Val Glu Glu  Glu Val Tyr 
    1055                 1060                 1065             


Pro Asn  Asn Thr Val Thr Cys  Asn Asp Tyr Thr Ala  Thr Gln Glu 
    1070                 1075                 1080             


Glu Tyr  Glu Gly Thr Tyr Thr  Ser Arg Asn Arg Gly  Tyr Asp Gly 
    1085                 1090                 1095             


Ala Tyr  Glu Ser Asn Ser Ser  Val Pro Ala Asp Tyr  Ala Ser Ala 
    1100                 1105                 1110             


Tyr Glu  Glu Lys Ala Tyr Thr  Asp Gly Arg Arg Asp  Asn Pro Cys 
    1115                 1120                 1125             


Glu Ser  Asn Arg Gly Tyr Arg  Asp Tyr Thr Pro Leu  Pro Ala Gly 
    1130                 1135                 1140             


Tyr Val  Thr Lys Glu Leu Glu  Tyr Phe Pro Glu Thr  Asp Lys Val 
    1145                 1150                 1155             


Trp Ile  Glu Ile Gly Glu Thr  Glu Gly Thr Phe Ile  Val Asp Ser 
    1160                 1165                 1170             


Val Glu  Leu Leu Leu Met Glu  Glu 
    1175                 1180     


<210>  6
<211>  1193
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hybrid toxin

<400>  6

Met Asp Asn Asn Pro Asn Ile Asn Glu Cys Ile Pro Tyr Asn Cys Leu 
1               5                   10                  15      


Ser Asn Pro Glu Val Glu Val Leu Gly Gly Glu Arg Ile Glu Thr Gly 
            20                  25                  30          


Tyr Thr Pro Ile Asp Ile Ser Leu Ser Leu Thr Gln Phe Leu Leu Ser 
        35                  40                  45              


Glu Phe Val Pro Gly Ala Gly Phe Val Leu Gly Leu Val Asp Ile Ile 
    50                  55                  60                  


Trp Gly Ile Phe Gly Pro Ser Gln Trp Asp Ala Phe Leu Val Gln Ile 
65                  70                  75                  80  


Glu Gln Leu Ile Asn Gln Arg Ile Glu Glu Phe Ala Arg Asn Gln Ala 
                85                  90                  95      


Ile Ser Arg Leu Glu Gly Leu Ser Asn Leu Tyr Gln Ile Tyr Ala Glu 
            100                 105                 110         


Ser Phe Arg Glu Trp Glu Ala Asp Pro Thr Asn Pro Ala Leu Arg Glu 
        115                 120                 125             


Glu Met Arg Ile Gln Phe Asn Asp Met Asn Ser Ala Leu Thr Thr Ala 
    130                 135                 140                 


Ile Pro Leu Phe Ala Val Gln Asn Tyr Gln Val Pro Leu Leu Ser Val 
145                 150                 155                 160 


Tyr Val Gln Ala Ala Asn Leu His Leu Ser Val Leu Arg Asp Val Ser 
                165                 170                 175     


Val Phe Gly Gln Arg Trp Gly Phe Asp Ala Ala Thr Ile Asn Ser Arg 
            180                 185                 190         


Tyr Asn Asp Leu Thr Arg Leu Ile Gly Asn Tyr Thr Asp His Ala Val 
        195                 200                 205             


Arg Trp Tyr Asn Thr Gly Leu Glu Arg Val Trp Gly Pro Asp Ser Arg 
    210                 215                 220                 


Asp Trp Ile Arg Tyr Asn Gln Phe Arg Arg Glu Leu Thr Leu Thr Val 
225                 230                 235                 240 


Leu Asp Ile Val Ser Leu Phe Pro Asn Tyr Asp Ser Arg Thr Tyr Pro 
                245                 250                 255     


Ile Arg Thr Val Ser Gln Leu Thr Arg Glu Ile Tyr Thr Asn Pro Val 
            260                 265                 270         


Leu Glu Asn Phe Asp Gly Ser Phe Arg Gly Ser Ala Gln Gly Ile Glu 
        275                 280                 285             


Gly Ser Ile Arg Ser Pro His Leu Met Asp Ile Leu Asn Ser Ile Thr 
    290                 295                 300                 


Ile Tyr Thr Asp Ala His Arg Gly Glu Tyr Tyr Trp Ser Gly His Gln 
305                 310                 315                 320 


Ile Met Ala Ser Pro Val Gly Phe Ser Gly Pro Glu Phe Thr Phe Pro 
                325                 330                 335     


Leu Tyr Gly Thr Met Gly Asn Ala Ala Pro Gln Gln Arg Ile Val Ala 
            340                 345                 350         


Gln Leu Gly Gln Gly Val Tyr Arg Thr Leu Ser Ser Thr Leu Tyr Arg 
        355                 360                 365             


Arg Pro Phe Asn Ile Gly Ile Asn Asn Gln Gln Leu Ser Val Leu Asp 
    370                 375                 380                 


Gly Thr Glu Phe Ala Tyr Gly Thr Ser Ser Asn Leu Pro Ser Ala Val 
385                 390                 395                 400 


Tyr Arg Lys Ser Gly Thr Val Asp Ser Leu Asp Glu Ile Pro Pro Gln 
                405                 410                 415     


Asn Asn Asn Val Pro Pro Arg Gln Gly Phe Ser His Arg Leu Ser His 
            420                 425                 430         


Val Ser Met Phe Arg Ser Gly Phe Ser Asn Ser Ser Val Ser Ile Ile 
        435                 440                 445             


Arg Ala Pro Met Phe Ser Trp Ile His Arg Ser Ala Thr Leu Thr Asn 
    450                 455                 460                 


Thr Ile Asp Pro Glu Arg Ile Asn Gln Ile Pro Leu Val Lys Gly Phe 
465                 470                 475                 480 


Arg Val Trp Gly Gly Thr Ser Val Ile Thr Gly Pro Gly Phe Thr Gly 
                485                 490                 495     


Gly Asp Ile Leu Arg Arg Asn Thr Phe Gly Asp Phe Val Ser Leu Gln 
            500                 505                 510         


Val Asn Ile Asn Ser Pro Ile Thr Gln Arg Tyr Arg Leu Arg Phe Arg 
        515                 520                 525             


Tyr Ala Ser Ser Arg Asp Ala Arg Val Ile Val Leu Thr Gly Ala Ala 
    530                 535                 540                 


Ser Thr Gly Val Gly Gly Gln Val Ser Val Asn Met Pro Leu Gln Lys 
545                 550                 555                 560 


Thr Met Glu Ile Gly Glu Asn Leu Thr Ser Arg Thr Phe Arg Tyr Thr 
                565                 570                 575     


Asp Phe Ser Asn Pro Phe Ser Phe Arg Ala Asn Pro Asp Ile Ile Gly 
            580                 585                 590         


Ile Ser Glu Gln Pro Leu Phe Gly Ala Gly Ser Ile Ser Ser Gly Glu 
        595                 600                 605             


Leu Tyr Ile Asp Lys Ile Glu Ile Ile Leu Ala Asp Ala Thr Phe Glu 
    610                 615                 620                 


Ala Glu Ser Asp Leu Glu Arg Ala Gln Lys Ala Val Asn Ala Leu Phe 
625                 630                 635                 640 


Thr Ser Ser Asn Gln Ile Gly Leu Lys Thr Asp Val Thr Asp Tyr His 
                645                 650                 655     


Ile Asp Gln Val Ser Asn Leu Val Asp Cys Leu Ser Asp Glu Phe Cys 
            660                 665                 670         


Leu Asp Glu Lys Lys Glu Leu Ser Glu Lys Val Lys His Ala Lys Arg 
        675                 680                 685             


Leu Ser Asp Glu Arg Asn Leu Leu Gln Asp Pro Asn Phe Arg Gly Ile 
    690                 695                 700                 


Asn Arg Gln Leu Asp Arg Gly Trp Arg Gly Ser Thr Asp Ile Thr Ile 
705                 710                 715                 720 


Gln Gly Gly Asp Asp Val Phe Lys Glu Asn Tyr Val Thr Leu Gln Gly 
                725                 730                 735     


Thr Phe Asp Glu Cys Tyr Pro Thr Tyr Leu Tyr Gln Pro Ile Asp Glu 
            740                 745                 750         


Ser Lys Leu Lys Ala Tyr Thr Arg Tyr Gln Leu Arg Gly Tyr Ile Glu 
        755                 760                 765             


Asp Ser Gln Asp Leu Glu Ile Tyr Leu Ile Arg Tyr Asn Ala Lys His 
    770                 775                 780                 


Glu Thr Val Asn Val Pro Gly Thr Gly Ser Leu Trp Pro Pro Ser Ala 
785                 790                 795                 800 


Pro Ser Pro Ile Gly Lys Cys Gly Glu Pro Asn Arg Cys Ala Pro His 
                805                 810                 815     


Leu Glu Trp Asn Pro Asp Leu Asp Cys Ser Cys Arg Asp Gly Glu Lys 
            820                 825                 830         


Cys Ala His His Ser His His Phe Ser Leu Asp Ile Asp Val Gly Cys 
        835                 840                 845             


Thr Asp Leu Asn Glu Asp Leu Gly Val Trp Val Ile Phe Lys Ile Lys 
    850                 855                 860                 


Thr Gln Asp Gly His Ala Arg Leu Gly Asn Leu Glu Phe Leu Glu Glu 
865                 870                 875                 880 


Lys Pro Leu Val Gly Glu Ala Leu Ala Arg Val Lys Arg Ala Glu Lys 
                885                 890                 895     


Lys Trp Arg Asp Lys Arg Glu Lys Leu Glu Trp Glu Thr Asn Ile Val 
            900                 905                 910         


Tyr Lys Glu Ala Lys Glu Ser Val Asp Ala Leu Phe Val Asn Ser Gln 
        915                 920                 925             


Tyr Asp Arg Leu Gln Ala Asp Thr Asn Ile Ala Met Ile His Ala Ala 
    930                 935                 940                 


Asp Lys Arg Val His Ser Ile Arg Glu Ala Tyr Leu Pro Glu Leu Ser 
945                 950                 955                 960 


Val Ile Pro Gly Val Asn Ala Ala Ile Phe Glu Glu Leu Glu Gly Arg 
                965                 970                 975     


Ile Phe Thr Ala Phe Ser Leu Tyr Asp Ala Arg Asn Val Ile Lys Asn 
            980                 985                 990         


Gly Asp Phe Asn Asn Gly Leu Ser  Cys Trp Asn Val Lys  Gly His Val 
        995                 1000                 1005             


Asp Val  Glu Glu Gln Asn Asn  His Arg Ser Val Leu  Val Val Pro 
    1010                 1015                 1020             


Glu Trp  Glu Ala Glu Val Ser  Gln Glu Val Arg Val  Cys Pro Gly 
    1025                 1030                 1035             


Arg Gly  Tyr Ile Leu Arg Val  Thr Ala Tyr Lys Glu  Gly Tyr Gly 
    1040                 1045                 1050             


Glu Gly  Cys Val Thr Ile His  Glu Ile Glu Asn Asn  Thr Asp Glu 
    1055                 1060                 1065             


Leu Lys  Phe Ser Asn Cys Val  Glu Glu Glu Val Tyr  Pro Asn Asn 
    1070                 1075                 1080             


Thr Val  Thr Cys Asn Asp Tyr  Thr Ala Thr Gln Glu  Glu Tyr Glu 
    1085                 1090                 1095             


Gly Thr  Tyr Thr Ser Arg Asn  Arg Gly Tyr Asp Gly  Ala Tyr Glu 
    1100                 1105                 1110             


Ser Asn  Ser Ser Val Pro Ala  Asp Tyr Ala Ser Ala  His Glu Glu 
    1115                 1120                 1125             


Lys Ala  Tyr Thr Asp Gly Arg  Arg Asp Asn Pro Cys  Glu Ser Asn 
    1130                 1135                 1140             


Arg Gly  Tyr Gly Asp Tyr Thr  Pro Leu Pro Ala Gly  Tyr Val Thr 
    1145                 1150                 1155             


Lys Glu  Leu Glu Tyr Phe Pro  Glu Thr Asp Lys Val  Trp Ile Glu 
    1160                 1165                 1170             


Ile Gly  Glu Thr Glu Gly Thr  Phe Ile Val Asp Ser  Val Glu Leu 
    1175                 1180                 1185             


Leu Leu  Met Glu Glu 
    1190             


<210>  7
<211>  881
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hybrid toxin

<400>  7

Met Asp Ile Leu Asn Ser Ile Thr Ile Tyr Thr Asp Ala His Arg Gly 
1               5                   10                  15      


Glu Tyr Tyr Trp Ser Gly His Gln Ile Met Ala Ser Pro Val Gly Phe 
            20                  25                  30          


Ser Gly Pro Glu Phe Thr Phe Pro Leu Tyr Gly Thr Met Gly Asn Ala 
        35                  40                  45              


Ala Pro Gln Gln Arg Ile Val Ala Gln Leu Gly Gln Gly Val Tyr Arg 
    50                  55                  60                  


Thr Leu Ser Ser Thr Leu Tyr Arg Arg Pro Phe Asn Ile Gly Ile Asn 
65                  70                  75                  80  


Asn Gln Gln Leu Ser Val Leu Asp Gly Thr Glu Phe Ala Tyr Gly Thr 
                85                  90                  95      


Ser Ser Asn Leu Pro Ser Ala Val Tyr Arg Lys Ser Gly Thr Val Asp 
            100                 105                 110         


Ser Leu Asp Glu Ile Pro Pro Gln Asn Asn Asn Val Pro Pro Arg Gln 
        115                 120                 125             


Gly Phe Ser His Arg Leu Ser His Val Ser Met Phe Arg Ser Gly Phe 
    130                 135                 140                 


Ser Asn Ser Ser Val Ser Ile Ile Arg Ala Pro Met Phe Ser Trp Ile 
145                 150                 155                 160 


His Arg Ser Ala Glu Phe Asn Asn Ile Ile Ala Ser Asp Ser Ile Thr 
                165                 170                 175     


Gln Ile Pro Leu Val Lys Ala His Thr Leu Gln Ser Gly Thr Thr Val 
            180                 185                 190         


Val Arg Gly Pro Gly Phe Thr Gly Gly Asp Ile Leu Arg Arg Thr Ser 
        195                 200                 205             


Gly Gly Pro Phe Ala Tyr Thr Ile Val Asn Ile Asn Gly Gln Leu Pro 
    210                 215                 220                 


Gln Arg Tyr Arg Ala Arg Ile Arg Tyr Ala Ser Thr Thr Asn Leu Arg 
225                 230                 235                 240 


Ile Tyr Val Thr Val Ala Gly Glu Arg Ile Phe Ala Gly Gln Phe Asn 
                245                 250                 255     


Lys Thr Met Asp Thr Gly Asp Pro Leu Thr Phe Gln Ser Phe Ser Tyr 
            260                 265                 270         


Ala Thr Ile Asn Thr Ala Phe Thr Phe Pro Met Ser Gln Ser Ser Phe 
        275                 280                 285             


Thr Val Gly Ala Asp Thr Phe Ser Ser Gly Asn Glu Val Tyr Ile Asp 
    290                 295                 300                 


Arg Phe Glu Leu Ile Pro Val Thr Ala Thr Leu Glu Ala Glu Tyr Asn 
305                 310                 315                 320 


Leu Glu Arg Ala Gln Lys Ala Val Asn Ala Leu Phe Thr Ser Thr Asn 
                325                 330                 335     


Gln Leu Gly Leu Lys Thr Asn Val Thr Asp Tyr His Ile Asp Gln Val 
            340                 345                 350         


Ser Asn Leu Val Thr Tyr Leu Ser Asp Glu Phe Cys Leu Asp Glu Lys 
        355                 360                 365             


Arg Glu Leu Ser Glu Lys Val Lys His Ala Lys Arg Leu Ser Asp Glu 
    370                 375                 380                 


Arg Asn Leu Leu Gln Asp Ser Asn Phe Lys Asp Ile Asn Arg Gln Pro 
385                 390                 395                 400 


Glu Arg Gly Trp Gly Gly Ser Thr Gly Ile Thr Ile Gln Gly Gly Asp 
                405                 410                 415     


Asp Val Phe Lys Glu Asn Tyr Val Thr Leu Ser Gly Thr Phe Asp Glu 
            420                 425                 430         


Cys Tyr Pro Thr Tyr Leu Tyr Gln Lys Ile Asp Glu Ser Lys Leu Lys 
        435                 440                 445             


Ala Phe Thr Arg Tyr Gln Leu Arg Gly Tyr Ile Glu Asp Ser Gln Asp 
    450                 455                 460                 


Leu Glu Ile Tyr Ser Ile Arg Tyr Asn Ala Lys His Glu Thr Val Asn 
465                 470                 475                 480 


Val Pro Gly Thr Gly Ser Leu Trp Pro Leu Ser Ala Gln Ser Pro Ile 
                485                 490                 495     


Gly Lys Cys Gly Glu Pro Asn Arg Cys Ala Pro His Leu Glu Trp Asn 
            500                 505                 510         


Pro Asp Leu Asp Cys Ser Cys Arg Asp Gly Glu Lys Cys Ala His His 
        515                 520                 525             


Ser His His Phe Ser Leu Asp Ile Asp Val Gly Cys Thr Asp Leu Asn 
    530                 535                 540                 


Glu Asp Leu Gly Val Trp Val Ile Phe Lys Ile Lys Thr Gln Asp Gly 
545                 550                 555                 560 


His Ala Arg Leu Gly Asn Leu Glu Phe Leu Glu Glu Lys Pro Leu Val 
                565                 570                 575     


Gly Glu Ala Leu Ala Arg Val Lys Arg Ala Glu Lys Lys Trp Arg Asp 
            580                 585                 590         


Lys Arg Glu Lys Leu Glu Trp Glu Thr Asn Ile Val Tyr Lys Glu Ala 
        595                 600                 605             


Lys Glu Ser Val Asp Ala Leu Phe Val Asn Ser Gln Tyr Asp Gln Leu 
    610                 615                 620                 


Gln Ala Asp Thr Asn Ile Ala Met Ile His Ala Ala Asp Lys Arg Val 
625                 630                 635                 640 


His Ser Ile Arg Glu Ala Tyr Leu Pro Glu Leu Ser Val Ile Pro Gly 
                645                 650                 655     


Val Asn Ala Ala Ile Phe Glu Glu Leu Glu Gly Arg Ile Phe Thr Ala 
            660                 665                 670         


Phe Ser Leu Tyr Asp Ala Arg Asn Val Ile Lys Asn Gly Asp Phe Asn 
        675                 680                 685             


Asn Gly Leu Ser Cys Trp Asn Val Lys Gly His Val Asp Val Glu Glu 
    690                 695                 700                 


Gln Asn Asn Gln Arg Ser Val Leu Val Val Pro Glu Trp Glu Ala Glu 
705                 710                 715                 720 


Val Ser Gln Glu Val Arg Val Cys Pro Gly Arg Gly Tyr Ile Leu Arg 
                725                 730                 735     


Val Thr Ala Tyr Lys Glu Gly Tyr Gly Glu Gly Cys Val Thr Ile His 
            740                 745                 750         


Glu Ile Glu Asn Asn Thr Asp Glu Leu Lys Phe Ser Asn Cys Val Glu 
        755                 760                 765             


Glu Glu Ile Tyr Pro Asn Asn Thr Val Thr Cys Asn Asp Tyr Thr Val 
    770                 775                 780                 


Asn Gln Glu Glu Tyr Gly Gly Ala Tyr Thr Ser Arg Asn Arg Gly Tyr 
785                 790                 795                 800 


Asn Glu Ala Pro Ser Val Pro Ala Asp Tyr Ala Ser Val Tyr Glu Glu 
                805                 810                 815     


Lys Ser Tyr Thr Asp Gly Arg Arg Glu Asn Pro Cys Glu Phe Asn Arg 
            820                 825                 830         


Gly Tyr Arg Asp Tyr Thr Pro Leu Pro Val Gly Tyr Val Thr Lys Glu 
        835                 840                 845             


Leu Glu Tyr Phe Pro Glu Thr Asp Lys Val Trp Ile Glu Ile Gly Glu 
    850                 855                 860                 


Thr Glu Gly Thr Phe Ile Val Asp Ser Val Glu Leu Leu Leu Met Glu 
865                 870                 875                 880 


Glu 
    


<210>  8
<211>  66
<212>  PRT
<213>  Sulfolobusacidocaldarius

<400>  8

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Lys Lys Val Trp Arg Val Gly Lys Met Val Ser Phe 
            20                  25                  30          


Thr Tyr Asp Asp Asn Gly Lys Thr Gly Arg Gly Ala Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  9
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  9

Met Val Lys Val Lys Phe Gly Pro Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Asp Val Trp Arg Trp Gly Lys Tyr Val Asp Phe 
            20                  25                  30          


Phe Tyr Asp Asp Asn Gly Lys Val Gly Ile Gly Ser Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  10
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  10

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Trp Ile Gly Arg Phe Gly Lys Ser Val Tyr Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Thr Gly Ala Gly Arg Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  11
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  11

Met Val Lys Val Lys Phe Arg Trp Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Trp Tyr Val Ala Arg Val Gly Lys Trp Val Leu Phe 
            20                  25                  30          


Gly Tyr Asp Asp Asn Gly Lys Arg Gly Ala Gly Arg Val Arg Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  12
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  12

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Ser Tyr Val Gln Arg Ala Gly Lys Ser Val Tyr Phe 
            20                  25                  30          


Asn Tyr Asp Asp Asn Gly Lys Thr Gly Gly Gly Arg Val Phe Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  13
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  13

Met Val Lys Val Lys Phe Val Leu Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Thr Tyr Val Ala Arg Tyr Gly Lys Phe Val Gln Phe 
            20                  25                  30          


Asp Tyr Asp Asp Asn Gly Lys Phe Gly Ala Gly Val Val Leu Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  14
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  14

Met Val Lys Val Lys Phe Met Arg Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Thr Tyr Val Thr Arg Trp Gly Lys Thr Val Ile Phe 
            20                  25                  30          


Tyr Tyr Asp Asp Asn Gly Lys Lys Gly His Gly Ser Val Leu Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  15
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  15

Met Val Lys Val Lys Phe Lys Val His Gly Lys Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Leu Ala Val Ala Arg Trp Gly Lys Ala Val Ile Phe 
            20                  25                  30          


Ala Tyr Asp Asp Asn Gly Lys His Gly Arg Gly Gln Val Ser Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  16
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  16

Met Val Lys Val Lys Phe His Gly Arg Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Phe Trp Val Tyr Arg Asp Gly Lys Arg Val Leu Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Arg Gly Phe Gly Ser Val Pro Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  17
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  17

Met Val Lys Val Lys Phe Ala Gln Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Tyr Arg Val Pro Arg His Gly Lys Ile Val Phe Phe 
            20                  25                  30          


Met Tyr Asp Asp Asn Gly Lys Gly Gly Phe Gly His Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  18
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  18

Met Val Lys Val Lys Phe Leu Met Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Lys Trp Val Asn Arg His Gly Lys Tyr Val Ala Phe 
            20                  25                  30          


Tyr Tyr Asp Asp Asn Gly Lys Thr Gly Gly Gly Glu Val Arg Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  19
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  19

Met Val Lys Val Lys Phe Gly Leu Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Arg Arg Val Leu Arg Leu Gly Lys Leu Val Ser Phe 
            20                  25                  30          


Thr Tyr Asp Asp Asn Gly Lys Ile Gly Leu Gly Asp Val His Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  20
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  20

Met Val Lys Val Lys Phe Lys Leu Thr Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Gln Trp Val Ala Arg Phe Gly Lys Phe Val Asp Phe 
            20                  25                  30          


Leu Tyr Asp Asp Asn Gly Lys Thr Gly Trp Gly Trp Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  21
<211>  66
<212>  PRT
<213>  Artificial Sequnece

<220>
<223>  synNAPS

<400>  21

Met Val Lys Val Lys Phe Lys Arg Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Leu His Val Leu Arg Val Gly Lys Tyr Val Arg Phe 
            20                  25                  30          


Ser Tyr Asp Asp Asn Gly Lys Leu Gly Ala Gly Tyr Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  22
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  22

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Ile Phe Val Tyr Arg Phe Gly Lys Phe Val Met Phe 
            20                  25                  30          


Ile Tyr Asp Asp Asn Gly Lys Thr Gly His Gly Asp Val Arg Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  23
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  23

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Gly Pro Trp Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Val 
            20                  25                  30          


Asp Val Trp Arg Trp Gly Lys Tyr Val Asp Phe Phe Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Val Gly Ile Gly Ser Val Thr Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                85                  90                  


<210>  24
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  24

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Val 
            20                  25                  30          


Trp Ile Gly Arg Phe Gly Lys Ser Val Tyr Phe Arg Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Thr Gly Ala Gly Arg Val Tyr Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                85                  90                  


<210>  25
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  25

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Arg Trp Gly Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Trp 
            20                  25                  30          


Tyr Val Ala Arg Val Gly Lys Trp Val Leu Phe Gly Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Arg Gly Ala Gly Arg Val Arg Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                85                  90                  


<210>  26
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  26

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Ser 
            20                  25                  30          


Tyr Val Gln Arg Ala Gly Lys Ser Val Tyr Phe Asn Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Thr Gly Gly Gly Arg Val Phe Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                85                  90                  


<210>  27
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  27

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Val Leu Lys Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Thr 
            20                  25                  30          


Tyr Val Ala Arg Tyr Gly Lys Phe Val Gln Phe Asp Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Phe Gly Ala Gly Val Val Leu Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                85                  90                  


<210>  28
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  28

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Met Arg Trp Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Thr 
            20                  25                  30          


Tyr Val Thr Arg Trp Gly Lys Thr Val Ile Phe Tyr Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Lys Gly His Gly Ser Val Leu Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                85                  90                  


<210>  29
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  29

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Lys Val His Gly Lys Glu Lys Glu Val Asp Thr Ser Lys Ile Leu 
            20                  25                  30          


Ala Val Ala Arg Trp Gly Lys Ala Val Ile Phe Ala Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys His Gly Arg Gly Gln Val Ser Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                85                  90                  


<210>  30
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  30

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Lys Val His Gly Lys Glu Lys Glu Val Asp Thr Ser Lys Ile Leu 
            20                  25                  30          


Ala Val Ala Arg Trp Gly Lys Ala Val Ile Phe Ala Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys His Gly Arg Gly Gln Val Ser Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                85                  90                  


<210>  31
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  31

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Ala Gln Gly Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Tyr 
            20                  25                  30          


Arg Val Pro Arg His Gly Lys Ile Val Phe Phe Met Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Gly Gly Phe Gly His Val Thr Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                85                  90                  


<210>  32
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  32

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Leu Met Lys Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Lys 
            20                  25                  30          


Trp Val Asn Arg His Gly Lys Tyr Val Ala Phe Tyr Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Thr Gly Gly Gly Glu Val Arg Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                85                  90                  


<210>  33
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  33

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Gly Leu Gly Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Arg 
            20                  25                  30          


Arg Val Leu Arg Leu Gly Lys Leu Val Ser Phe Thr Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Ile Gly Leu Gly Asp Val His Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                85                  90                  


<210>  34
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  34

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Lys Leu Thr Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Gln 
            20                  25                  30          


Trp Val Ala Arg Phe Gly Lys Phe Val Asp Phe Leu Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Thr Gly Trp Gly Trp Val Tyr Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                85                  90                  


<210>  35
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  35

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Lys Arg Trp Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Leu 
            20                  25                  30          


His Val Leu Arg Val Gly Lys Tyr Val Arg Phe Ser Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Leu Gly Ala Gly Tyr Val Thr Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                85                  90                  


<210>  36
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  36

Met Arg Gly Ser His His His His His His Gly Ser Val Lys Val Lys 
1               5                   10                  15      


Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Ile 
            20                  25                  30          


Phe Val Tyr Arg Phe Gly Lys Phe Val Met Phe Ile Tyr Asp Asp Asn 
        35                  40                  45              


Gly Lys Thr Gly His Gly Asp Val Arg Glu Lys Asp Ala Pro Lys Glu 
    50                  55                  60                  


Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu Lys Lys Leu Gly Ser 
65                  70                  75                  80  


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                85                  90                  


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  His-tag

<400>  37

Arg Gly Ser His His His His His His Gly Ser 
1               5                   10      


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avidin-tag

<400>  38

Leu Gly Ser Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp 
1               5                   10                  15      


His 
    


<210>  39
<211>  285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  39
atgagaggat cgcatcacca tcaccatcac ggatccgtca aggtgaaatt caaatataaa       60

ggcgaagaaa aagaagtgga cactagtaag atcgtgtgga ttgggcgttt cggcaaatcc      120

gtgtactttc gctacgacga caacggcaag accggcgccg gcagggtgta cgagaaagat      180

gccccgaaag agttattaga tatgttagcg cgtgcggaac gcgagaaaaa gcttggctcg      240

ggtctgaacg atatcttcga agctcagaaa atcgaatggc acgaa                      285


<210>  40
<211>  285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  40
atgagaggat cgcatcacca tcaccatcac ggatccgtca aggtgaaatt cgcccagggg       60

ggcgaagaaa aagaagtgga cactagtaag atctaccgcg ttccccgtca cggcaaaatc      120

gtgttcttta tgtacgacga caacggcaag gggggcttcg gccacgtgac cgagaaagat      180

gccccgaaag agttattaga tatgttagcg cgtgcggaac gcgagaaaaa gcttggctcg      240

ggtctgaacg atatcttcga agctcagaaa atcgaatggc acgaa                      285


<210>  41
<211>  285
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synNAPS

<400>  41
atgagaggat cgcatcacca tcaccatcac ggatccgtca aggtgaaatt caagcggtgg       60

ggcgaagaaa aagaagtgga cactagtaag atcctgcacg ttctccgtgt gggcaaatac      120

gtgcgcttta gctacgacga caacggcaag ctgggcgcgg gctacgtgac cgagaaagat      180

gccccgaaag agttattaga tatgttagcg cgtgcggaac gcgagaaaaa gcttggctcg      240

ggtctgaacg atatcttcga agctcagaaa atcgaatggc acgaa                      285


<210>  42
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS-1ABF

<400>  42

Gly Pro Trp Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Val Asp 
1               5                   10                  15      


Val Trp Arg Trp Gly Lys Tyr Val Asp Phe Phe Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Val Gly Ile Gly Ser Val Thr 
        35                  40  


<210>  43
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS-2ABF

<400>  43

Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Val Trp 
1               5                   10                  15      


Ile Gly Arg Phe Gly Lys Ser Val Tyr Phe Arg Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Thr Gly Ala Gly Arg Val Tyr 
        35                  40  


<210>  44
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS-3ABF

<400>  44

Arg Trp Gly Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Trp Tyr 
1               5                   10                  15      


Val Ala Arg Val Gly Lys Trp Val Leu Phe Gly Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Arg Gly Ala Gly Arg Val Arg 
        35                  40  


<210>  45
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS-4ABF

<400>  45

Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Ser Tyr 
1               5                   10                  15      


Val Gln Arg Ala Gly Lys Ser Val Tyr Phe Asn Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Thr Gly Gly Gly Arg Val Phe 
        35                  40  


<210>  46
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS-5ABF

<400>  46

Val Leu Lys Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Thr Tyr 
1               5                   10                  15      


Val Ala Arg Tyr Gly Lys Phe Val Gln Phe Asp Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Phe Gly Ala Gly Val Val Leu 
        35                  40  


<210>  47
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS-6ABF

<400>  47

Met Arg Trp Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Thr Tyr 
1               5                   10                  15      


Val Thr Arg Trp Gly Lys Thr Val Ile Phe Tyr Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Lys Gly His Gly Ser Val Leu 
        35                  40  


<210>  48
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS-7ABF

<400>  48

Lys Val His Gly Lys Glu Lys Glu Val Asp Thr Ser Lys Ile Leu Ala 
1               5                   10                  15      


Val Ala Arg Trp Gly Lys Ala Val Ile Phe Ala Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys His Gly Arg Gly Gln Val Ser 
        35                  40  


<210>  49
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS-8ABF

<400>  49

His Gly Arg Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Phe Trp 
1               5                   10                  15      


Val Tyr Arg Asp Gly Lys Arg Val Leu Phe Arg Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Arg Gly Phe Gly Ser Val Pro 
        35                  40  


<210>  50
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS-9ABF

<400>  50

Ala Gln Gly Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Tyr Arg 
1               5                   10                  15      


Val Pro Arg His Gly Lys Ile Val Phe Phe Met Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Gly Gly Phe Gly His Val Thr 
        35                  40  


<210>  51
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS-10ABF

<400>  51

Leu Met Lys Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Lys Trp 
1               5                   10                  15      


Val Asn Arg His Gly Lys Tyr Val Ala Phe Tyr Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Thr Gly Gly Gly Glu Val Arg 
        35                  40  


<210>  52
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS-11ABF

<400>  52

Gly Leu Gly Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Arg Arg 
1               5                   10                  15      


Val Leu Arg Leu Gly Lys Leu Val Ser Phe Thr Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Ile Gly Leu Gly Asp Val His 
        35                  40  


<210>  53
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS-12ABF

<400>  53

Lys Leu Thr Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Gln Trp 
1               5                   10                  15      


Val Ala Arg Phe Gly Lys Phe Val Asp Phe Leu Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Thr Gly Trp Gly Trp Val Tyr 
        35                  40  


<210>  54
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS-13ABF

<400>  54

Lys Arg Trp Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Leu His 
1               5                   10                  15      


Val Leu Arg Val Gly Lys Tyr Val Arg Phe Ser Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Leu Gly Ala Gly Tyr Val Thr 
        35                  40  


<210>  55
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS-14ABF

<400>  55

Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Ile Phe 
1               5                   10                  15      


Val Tyr Arg Phe Gly Lys Phe Val Met Phe Ile Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Thr Gly His Gly Asp Val Arg 
        35                  40  


<210>  56
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS variant

<400>  56

Met Val Lys Val Lys Phe Ala Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Trp Ile Gly Arg Phe Gly Lys Ser Val Tyr Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Thr Gly Ala Gly Arg Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  57
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS2 variant

<400>  57

Met Val Lys Val Lys Phe Lys Ala Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Trp Ile Gly Arg Phe Gly Lys Ser Val Tyr Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Thr Gly Ala Gly Arg Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  58
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS2 variant

<400>  58

Met Val Lys Val Lys Phe Lys Tyr Ala Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Trp Ile Gly Arg Phe Gly Lys Ser Val Tyr Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Thr Gly Ala Gly Arg Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  59
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS2 variant

<400>  59

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Ala Trp Ile Gly Arg Phe Gly Lys Ser Val Tyr Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Thr Gly Ala Gly Arg Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  60
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS2 variant

<400>  60

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Ala Ile Gly Arg Phe Gly Lys Ser Val Tyr Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Thr Gly Ala Gly Arg Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  61
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS2 variant

<400>  61

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Trp Ala Gly Arg Phe Gly Lys Ser Val Tyr Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Thr Gly Ala Gly Arg Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  62
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS2 variant

<400>  62

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Trp Ile Ala Arg Phe Gly Lys Ser Val Tyr Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Thr Gly Ala Gly Arg Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  63
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS2 variant

<400>  63

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Trp Ile Gly Arg Ala Gly Lys Ser Val Tyr Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Thr Gly Ala Gly Arg Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  64
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS2 variant

<400>  64

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Trp Ile Gly Arg Phe Gly Lys Ala Val Tyr Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Thr Gly Ala Gly Arg Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  65
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS2 variant

<400>  65

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Trp Ile Gly Arg Phe Gly Lys Ser Val Ala Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Thr Gly Ala Gly Arg Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  66
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS2 variant

<400>  66

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Trp Ile Gly Arg Phe Gly Lys Ser Val Tyr Phe 
            20                  25                  30          


Ala Tyr Asp Asp Asn Gly Lys Thr Gly Ala Gly Arg Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  67
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS2 variant

<400>  67

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Trp Ile Gly Arg Phe Gly Lys Ser Val Tyr Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Ala Gly Ala Gly Arg Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  68
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS2 variant

<400>  68

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Trp Ile Gly Arg Phe Gly Lys Ser Val Tyr Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Thr Gly Ala Gly Ala Val Tyr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  69
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS2 variant

<400>  69

Met Val Lys Val Lys Phe Lys Tyr Lys Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Val Trp Ile Gly Arg Phe Gly Lys Ser Val Tyr Phe 
            20                  25                  30          


Arg Tyr Asp Asp Asn Gly Lys Thr Gly Ala Gly Arg Val Ala Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  70
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS9 variant

<400>  70

Met Val Lys Val Lys Phe Ala Ala Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Tyr Arg Val Pro Arg His Gly Lys Ile Val Phe Phe 
            20                  25                  30          


Met Tyr Asp Asp Asn Gly Lys Gly Gly Phe Gly His Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  71
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS9 variant

<400>  71

Met Val Lys Val Lys Phe Ala Gln Ala Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Tyr Arg Val Pro Arg His Gly Lys Ile Val Phe Phe 
            20                  25                  30          


Met Tyr Asp Asp Asn Gly Lys Gly Gly Phe Gly His Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  72
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS9 variant

<400>  72

Met Val Lys Val Lys Phe Ala Gln Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Ala Arg Val Pro Arg His Gly Lys Ile Val Phe Phe 
            20                  25                  30          


Met Tyr Asp Asp Asn Gly Lys Gly Gly Phe Gly His Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  73
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS9 variant

<400>  73

Met Val Lys Val Lys Phe Ala Gln Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Tyr Ala Val Pro Arg His Gly Lys Ile Val Phe Phe 
            20                  25                  30          


Met Tyr Asp Asp Asn Gly Lys Gly Gly Phe Gly His Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  74
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS9 variant

<400>  74

Met Val Lys Val Lys Phe Ala Gln Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Tyr Arg Val Ala Arg His Gly Lys Ile Val Phe Phe 
            20                  25                  30          


Met Tyr Asp Asp Asn Gly Lys Gly Gly Phe Gly His Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  75
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS9 variant

<400>  75

Met Val Lys Val Lys Phe Ala Gln Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Tyr Arg Val Pro Arg Ala Gly Lys Ile Val Phe Phe 
            20                  25                  30          


Met Tyr Asp Asp Asn Gly Lys Gly Gly Phe Gly His Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  76
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS9 variant

<400>  76

Met Val Lys Val Lys Phe Ala Gln Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Tyr Arg Val Pro Arg His Gly Lys Ala Val Phe Phe 
            20                  25                  30          


Met Tyr Asp Asp Asn Gly Lys Gly Gly Phe Gly His Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  77
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS9 variant

<400>  77

Met Val Lys Val Lys Phe Ala Gln Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Tyr Arg Val Pro Arg His Gly Lys Ile Val Ala Phe 
            20                  25                  30          


Met Tyr Asp Asp Asn Gly Lys Gly Gly Phe Gly His Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  78
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS9 variant

<400>  78

Met Val Lys Val Lys Phe Ala Gln Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Tyr Arg Val Pro Arg His Gly Lys Ile Val Phe Phe 
            20                  25                  30          


Ala Tyr Asp Asp Asn Gly Lys Gly Gly Phe Gly His Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  79
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS9 variant

<400>  79

Met Val Lys Val Lys Phe Ala Gln Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Tyr Arg Val Pro Arg His Gly Lys Ile Val Phe Phe 
            20                  25                  30          


Met Tyr Asp Asp Asn Gly Lys Ala Gly Phe Gly His Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  80
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS9 variant

<400>  80

Met Val Lys Val Lys Phe Ala Gln Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Tyr Arg Val Pro Arg His Gly Lys Ile Val Phe Phe 
            20                  25                  30          


Met Tyr Asp Asp Asn Gly Lys Gly Gly Ala Gly His Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  81
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS9 variant

<400>  81

Met Val Lys Val Lys Phe Ala Gln Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Tyr Arg Val Pro Arg His Gly Lys Ile Val Phe Phe 
            20                  25                  30          


Met Tyr Asp Asp Asn Gly Lys Gly Gly Phe Gly Ala Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  82
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS9 variant

<400>  82

Met Val Lys Val Lys Phe Ala Gln Gly Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Tyr Arg Val Pro Arg His Gly Lys Ile Val Phe Phe 
            20                  25                  30          


Met Tyr Asp Asp Asn Gly Lys Gly Gly Phe Gly His Val Ala Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  83
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS13 variant

<400>  83

Met Val Lys Val Lys Phe Ala Arg Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Leu His Val Leu Arg Val Gly Lys Tyr Val Arg Phe 
            20                  25                  30          


Ser Tyr Asp Asp Asn Gly Lys Leu Gly Ala Gly Tyr Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  84
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS13 variant

<400>  84

Met Val Lys Val Lys Phe Lys Ala Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Leu His Val Leu Arg Val Gly Lys Tyr Val Arg Phe 
            20                  25                  30          


Ser Tyr Asp Asp Asn Gly Lys Leu Gly Ala Gly Tyr Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  85
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS13 variant

<400>  85

Met Val Lys Val Lys Phe Lys Arg Ala Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Leu His Val Leu Arg Val Gly Lys Tyr Val Arg Phe 
            20                  25                  30          


Ser Tyr Asp Asp Asn Gly Lys Leu Gly Ala Gly Tyr Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  86
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS13 variant

<400>  86

Met Val Lys Val Lys Phe Lys Arg Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Ala His Val Leu Arg Val Gly Lys Tyr Val Arg Phe 
            20                  25                  30          


Ser Tyr Asp Asp Asn Gly Lys Leu Gly Ala Gly Tyr Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  87
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS13 variant

<400>  87

Met Val Lys Val Lys Phe Lys Arg Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Leu Ala Val Leu Arg Val Gly Lys Tyr Val Arg Phe 
            20                  25                  30          


Ser Tyr Asp Asp Asn Gly Lys Leu Gly Ala Gly Tyr Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  88
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS13 variant

<400>  88

Met Val Lys Val Lys Phe Lys Arg Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Leu His Val Ala Arg Val Gly Lys Tyr Val Arg Phe 
            20                  25                  30          


Ser Tyr Asp Asp Asn Gly Lys Leu Gly Ala Gly Tyr Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  89
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS13 variant

<400>  89

Met Val Lys Val Lys Phe Lys Arg Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Leu His Val Leu Arg Ala Gly Lys Tyr Val Arg Phe 
            20                  25                  30          


Ser Tyr Asp Asp Asn Gly Lys Leu Gly Ala Gly Tyr Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  90
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS13 variant

<400>  90

Met Val Lys Val Lys Phe Lys Arg Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Leu His Val Leu Arg Val Gly Lys Ala Val Arg Phe 
            20                  25                  30          


Ser Tyr Asp Asp Asn Gly Lys Leu Gly Ala Gly Tyr Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  91
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS13 variant

<400>  91

Met Val Lys Val Lys Phe Lys Arg Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Leu His Val Leu Arg Val Gly Lys Tyr Val Ala Phe 
            20                  25                  30          


Ser Tyr Asp Asp Asn Gly Lys Leu Gly Ala Gly Tyr Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  92
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS13 variant

<400>  92

Met Val Lys Val Lys Phe Lys Arg Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Leu His Val Leu Arg Val Gly Lys Tyr Val Arg Phe 
            20                  25                  30          


Ala Tyr Asp Asp Asn Gly Lys Leu Gly Ala Gly Tyr Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  93
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS13 variant

<400>  93

Met Val Lys Val Lys Phe Lys Arg Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Leu His Val Leu Arg Val Gly Lys Tyr Val Arg Phe 
            20                  25                  30          


Ser Tyr Asp Asp Asn Gly Lys Ala Gly Ala Gly Tyr Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  94
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS13 variant

<400>  94

Met Val Lys Val Lys Phe Lys Arg Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Leu His Val Leu Arg Val Gly Lys Tyr Val Arg Phe 
            20                  25                  30          


Ser Tyr Asp Asp Asn Gly Lys Leu Gly Ala Gly Ala Val Thr Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  95
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS13 variant

<400>  95

Met Val Lys Val Lys Phe Lys Arg Trp Gly Glu Glu Lys Glu Val Asp 
1               5                   10                  15      


Thr Ser Lys Ile Leu His Val Leu Arg Val Gly Lys Tyr Val Arg Phe 
            20                  25                  30          


Ser Tyr Asp Asp Asn Gly Lys Leu Gly Ala Gly Tyr Val Ala Glu Lys 
        35                  40                  45              


Asp Ala Pro Lys Glu Leu Leu Asp Met Leu Ala Arg Ala Glu Arg Glu 
    50                  55                  60                  


Lys Lys 
65      


<210>  96
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS2 consensus binding domain


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid

<400>  96

Xaa Xaa Xaa Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Xaa Trp 
1               5                   10                  15      


Xaa Xaa Arg Xaa Gly Lys Ser Val Tyr Phe Xaa Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Xaa Gly Ala Gly Arg Val Xaa 
        35                  40  


<210>  97
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS9 consensus binding domain


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid

<400>  97

Xaa Xaa Xaa Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Xaa Xaa 
1               5                   10                  15      


Val Xaa Arg Xaa Gly Lys Ile Val Xaa Phe Xaa Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Xaa Gly Phe Gly Xaa Val Xaa 
        35                  40  


<210>  98
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synNAPS13 consensus binding domain


<220>
<221>  misc_feature
<222>  (1)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid

<400>  98

Xaa Xaa Xaa Gly Glu Glu Lys Glu Val Asp Thr Ser Lys Ile Xaa His 
1               5                   10                  15      


Val Xaa Arg Xaa Gly Lys Xaa Val Arg Phe Xaa Tyr Asp Asp Asn Gly 
            20                  25                  30          


Lys Leu Gly Xaa Gly Tyr Val Xaa 
        35                  40  


