                         SEQUENCE LISTING

<110>  Yale University
       Icahn School of Medicine at Mount Sinai
       Schlessinger, Joseph
       Lee, Sangwon
       Schlessinger, Avner
       Ung, Man-Un
 
<120>  Compositions and Methods for Treating or Preventing Endocrine 
       FGF23-Linked Diseases

<130>  047162-7158WO1(00837)

<150>  US 62/598,273
<151>  2017-12-13

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys 
    1010         


<210>  2
<211>  1044
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile Phe 
1               5                   10                  15      


Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met Ser Asn 
            20                  25                  30          


Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile Leu Leu Arg 
        35                  40                  45              


Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Ile Trp Ser Lys Asn 
    50                  55                  60                  


Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu Phe Leu Tyr Asp Thr 
65                  70                  75                  80  


Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly Thr Gly Ala Leu Gln Val 
                85                  90                  95      


Glu Gly Ser Trp Lys Lys Asp Gly Lys Gly Pro Ser Ile Trp Asp His 
            100                 105                 110         


Phe Ile His Thr His Leu Lys Asn Val Ser Ser Thr Asn Gly Ser Ser 
        115                 120                 125             


Asp Ser Tyr Ile Phe Leu Glu Lys Asp Leu Ser Ala Leu Asp Phe Ile 
    130                 135                 140                 


Gly Val Ser Phe Tyr Gln Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro 
145                 150                 155                 160 


Asp Gly Ile Val Thr Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser 
                165                 170                 175     


Thr Leu Leu Asp Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr 
            180                 185                 190         


Leu Tyr His Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly 
        195                 200                 205             


Trp Lys Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr 
    210                 215                 220                 


Cys Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His 
225                 230                 235                 240 


Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His Ala 
                245                 250                 255     


Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly His Asn 
            260                 265                 270         


Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn Thr His Phe 
        275                 280                 285             


Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu Gly Ser His Trp 
    290                 295                 300                 


Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp Ile Phe Lys Cys Gln 
305                 310                 315                 320 


Gln Ser Met Val Ser Val Leu Gly Trp Phe Ala Asn Pro Ile His Gly 
                325                 330                 335     


Asp Gly Asp Tyr Pro Glu Gly Met Arg Lys Lys Leu Phe Ser Val Leu 
            340                 345                 350         


Pro Ile Phe Ser Glu Ala Glu Lys His Glu Met Arg Gly Thr Ala Asp 
        355                 360                 365             


Phe Phe Ala Phe Ser Phe Gly Pro Asn Asn Phe Lys Pro Leu Asn Thr 
    370                 375                 380                 


Met Ala Lys Met Gly Gln Asn Val Ser Leu Asn Leu Arg Glu Ala Leu 
385                 390                 395                 400 


Asn Trp Ile Lys Leu Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Glu 
                405                 410                 415     


Asn Gly Trp Phe Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala 
            420                 425                 430         


Ile Tyr Met Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg 
        435                 440                 445             


Leu Asp Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp 
    450                 455                 460                 


Gly Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr 
465                 470                 475                 480 


Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser Ala 
                485                 490                 495     


His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu Lys Glu 
            500                 505                 510         


Ser Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe Ser Trp Gly 
        515                 520                 525             


Val Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala Ser Ser Pro Gln 
    530                 535                 540                 


Phe Ser Asp Pro His Leu Tyr Val Trp Asn Ala Thr Gly Asn Arg Leu 
545                 550                 555                 560 


Leu His Arg Val Glu Gly Val Arg Leu Lys Thr Arg Pro Ala Gln Cys 
                565                 570                 575     


Thr Asp Phe Val Asn Ile Lys Lys Gln Leu Glu Met Leu Ala Arg Met 
            580                 585                 590         


Lys Val Thr His Tyr Arg Phe Ala Leu Asp Trp Ala Ser Val Leu Pro 
        595                 600                 605             


Thr Gly Asn Leu Ser Ala Val Asn Arg Gln Ala Leu Arg Tyr Tyr Arg 
    610                 615                 620                 


Cys Val Val Ser Glu Gly Leu Lys Leu Gly Ile Ser Ala Met Val Thr 
625                 630                 635                 640 


Leu Tyr Tyr Pro Thr His Ala His Leu Gly Leu Pro Glu Pro Leu Leu 
                645                 650                 655     


His Ala Asp Gly Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala 
            660                 665                 670         


Tyr Ala Gly Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp 
        675                 680                 685             


Ile Thr Ile Asn Glu Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser 
    690                 695                 700                 


Gly Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala 
705                 710                 715                 720 


Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg Gly 
                725                 730                 735     


Ala Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala Asn Pro 
            740                 745                 750         


Tyr Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu Gln Phe Glu 
        755                 760                 765             


Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly Asp Tyr Pro Ala 
    770                 775                 780                 


Ala Met Arg Glu Tyr Ile Ala Ser Lys His Arg Arg Gly Leu Ser Ser 
785                 790                 795                 800 


Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu Arg Arg Leu Leu Lys Gly 
                805                 810                 815     


Thr Val Asp Phe Cys Ala Leu Asn His Phe Thr Thr Arg Phe Val Met 
            820                 825                 830         


His Glu Gln Leu Ala Gly Ser Arg Tyr Asp Ser Asp Arg Asp Ile Gln 
        835                 840                 845             


Phe Leu Gln Asp Ile Thr Arg Leu Ser Ser Pro Thr Arg Leu Ala Val 
    850                 855                 860                 


Ile Pro Trp Gly Val Arg Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr 
865                 870                 875                 880 


Gly Asp Met Asp Ile Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala 
                885                 890                 895     


Leu Glu Asp Asp Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln 
            900                 905                 910         


Glu Val Leu Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr 
        915                 920                 925             


Tyr Ala Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe 
    930                 935                 940                 


Phe Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys 
945                 950                 955                 960 


Val Ile Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg Cys 
                965                 970                 975     


Ser Gln Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe Leu Val 
            980                 985                 990         


Gln Lys Lys Pro Leu Ile Phe Leu  Gly Cys Cys Phe Phe  Ser Thr Leu 
        995                 1000                 1005             


Val Leu  Leu Leu Ser Ile Ala  Ile Phe Gln Arg Gln  Lys Arg Arg 
    1010                 1015                 1020             


Lys Phe  Trp Lys Ala Lys Asn  Leu Gln His Ile Pro  Leu Lys Lys 
    1025                 1030                 1035             


Gly Lys  Arg Val Val Ser 
    1040                 


<210>  3
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Ser Gly Cys Val Val Val His Val Trp Ile Leu Ala Gly Leu 
1               5                   10                  15      


Trp Leu Ala Val Ala Gly Arg Pro Leu Ala Phe Ser Asp Ala Gly Pro 
            20                  25                  30          


His Val His Tyr Gly Trp Gly Asp Pro Ile Arg Leu Arg His Leu Tyr 
        35                  40                  45              


Thr Ser Gly Pro His Gly Leu Ser Ser Cys Phe Leu Arg Ile Arg Ala 
    50                  55                  60                  


Asp Gly Val Val Asp Cys Ala Arg Gly Gln Ser Ala His Ser Leu Leu 
65                  70                  75                  80  


Glu Ile Lys Ala Val Ala Leu Arg Thr Val Ala Ile Lys Gly Val His 
                85                  90                  95      


Ser Val Arg Tyr Leu Cys Met Gly Ala Asp Gly Lys Met Gln Gly Leu 
            100                 105                 110         


Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe Glu Glu Glu Ile Arg Pro 
        115                 120                 125             


Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys His Arg Leu Pro Val Ser 
    130                 135                 140                 


Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr Lys Asn Arg Gly Phe Leu 
145                 150                 155                 160 


Pro Leu Ser His Phe Leu Pro Met Leu Pro Met Val Pro Glu Glu Pro 
                165                 170                 175     


Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met Phe Ser Ser Pro Leu 
            180                 185                 190         


Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu Glu Ala 
        195                 200                 205             


Val Arg Ser Pro Ser Phe Glu Lys 
    210                 215     


<210>  4
<211>  209
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser Asp 
            180                 185                 190         


Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala 
        195                 200                 205             


Ser 
    


<210>  5
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210>  6
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  6

Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly 
1               5                   10                  15      


Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
            20                  25          


<210>  7
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr 
1               5                   10                  15      


Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            20                  25              


<210>  8
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro 
1               5                   10                  15      


Arg Ala Arg Met Thr Pro Ala Pro Ala Ser 
            20                  25      


