                               SEQUENCE LISTING

<110> AUKERA, INC.
 
<120> METHODS AND COMPOSITIONS FOR VAULT NANOPARTICLE IMMOBILIZATION OF
      THERAPEUTIC MOLECULES AND FOR VAULT TARGETING

<130> 50071-701.601

<140> PCT/US2018/065168
<141> 2018-12-12

<150> 62/598,378
<151> 2017-12-13

<160> 20    

<170> PatentIn version 3.5

<210> 1
<211> 5175
<212> DNA
<213> Homo sapiens

<400> 1
atggtgatgg gaatctttgc aaattgtatc ttctgtttga aagtgaagta cttacctcag       60

cagcagaaga aaaagctaca aactgacatt aaggaaaatg gcggaaagtt ttccttttcg      120

ttaaatcctc agtgcacaca tataatctta gataatgctg atgttctgag tcagtaccaa      180

ctgaattcta tccaaaagaa ccacgttcat attgcaaacc cagattttat atggaaatct      240

atcagggaaa agagactctt ggatgtaaag aattatgatc cttataagcc cctggacatc      300

acaccacctc ctgatcagaa ggcgagcagt tctgaagtga aaacagaagg tctatgcccg      360

gacagtgcca cagaggagga agacactgtg gaactcactg agtttggtat gcagaatgtt      420

gaaattcctc atcttcctca agattttgaa gttgcaaaat ataacacctt ggagaaagtg      480

ggaatggagg gaggccagga agctgtggtg gtggagcttc agtgttcgcg ggactccagg      540

gactgtcctt tcctgatatc ctcacacttc ctcctggatg atggcatgga gactagaaga      600

cagtttgcta taaagaaaac ctctgaagat gcaagtgaat actttgaaaa ttacattgaa      660

gaactgaaga aacaaggatt tctactaaga gaacatttca cacctgaagc aacccaatta      720

gcatctgaac aattgcaagc attgcttttg gaggaagtca tgaattcaag cactctgagc      780

caagaggtga gcgatttagt agagatgatt tgggcagagg ccctgggcca cctggaacac      840

atgcttctca agccagtgaa caggattagc ctcaacgatg tgagcaaggc agaggggatt      900

ctccttctag taaaggcagc actgaaaaat ggagaaacag cagagcaatt gcaaaagatg      960

atgacagagt tttacagact gatacctcac aaaggcacaa tgcccaaaga agtgaacctg     1020

ggactattgg ctaagaaagc agacctctgc cagctaataa gagacatggt taatgtctgt     1080

gaaactaatt tgtccaaacc caacccacca tccctggcca aataccgagc tttgaggtgc     1140

aaaattgagc atgttgaaca gaatactgaa gaatttctca gggttagaaa agaggttttg     1200

cagaatcatc acagtaagag cccagtggat gtcttgcaga tatttagagt tggcagagtg     1260

aatgaaacca cagagttttt gagcaaactt ggtaatgtga ggcccttgtt gcatggttct     1320

cctgtacaaa acatcgtggg aatcttgtgt cgagggttgc ttttacccaa agtagtggaa     1380

gatcgtggtg tgcaaagaac agacgtcgga aaccttggaa gtgggattta tttcagtgat     1440

tcgctcagta caagtatcaa gtactcacac ccgggagaga cagatggcac cagactcctg     1500

ctcatttgtg acgtagccct cggaaagtgt atggacttac atgagaagga cttttcctta     1560

actgaagcac caccaggcta cgacagtgtg catggagttt cgcaaacagc ctctgtcacc     1620

acagactttg aggatgatga atttgttgtc tataaaacca atcaggttaa aatgaaatat     1680

attattaaat tttccatgcc tggagatcag ataaaggact ttcatcctag tgatcatact     1740

gaattagagg aatacagacc tgagttttca aatttttcaa aggttgaaga ttaccagtta     1800

ccagatgcca aaacttccag cagcaccaag gccggcctcc aggatgcctc tgggaacttg     1860

gttcctctgg aggatgtcca catcaaaggg agaatcatag acactgtagc ccaggtcatt     1920

gtttttcaga catacacaaa taaaagtcac gtgcccattg aggcaaaata tatctttcct     1980

ttggatgaca aggccgctgt gtgtggcttc gaagccttca tcaatgggaa gcacatagtt     2040

ggagagatta aagagaagga agaagcccag caagagtacc tagaagccgt gacccagggc     2100

catggcgctt acctgatgag tcaggatgct ccggacgttt ttactgtaag tgttggaaac     2160

ttacccccta aggctaaggt tcttataaaa attacctaca tcacagaact cagcatcctg     2220

ggcactgttg gtgtcttttt catgcccgcc accgtagcac cctggcaaca ggacaaggct     2280

ttgaatgaaa accttcagga tacagtagag aagatttgta taaaagaaat aggaacaaag     2340

caaagcttct ctttgactat gtctattgag atgccgtatg tgattgaatt cattttcagt     2400

gatacacatg aactgaaaca aaagcgcaca gactgcaaag ctgtcattag caccatggaa     2460

ggcagctcct tagacagcag tggattttct ctccacatcg gtttgtctgc tgcctatctc     2520

ccaagaatgt gggttgaaaa acatccagaa aaagaaagcg aggcttgcat gcttgtcttt     2580

caacccgatc tcgatgtcga cctccctgac ctagccagtg agagcgaagt gattatttgt     2640

cttgactgct ccagttccat ggagggtgtg acattcttgc aagccaagca aatcgccttg     2700

catgcgctgt ccttggtggg tgagaagcag aaagtaaata ttatccagtt cggcacaggt     2760

tacaaggagc tattttcgta tcctaagcat atcacaagca ataccatggc agcagagttc     2820

atcatgtctg ccacacctac catggggaac acagacttct ggaaaacact ccgatatctt     2880

agcttattgt accctgctcg agggtcacgg aacatcctcc tggtgtctga tgggcacctc     2940

caggatgaga gcctgacatt acagctcgtg aagaggagcc gcccgcacac caggttattc     3000

gcctgcggta tcggttctac agcaaatcgt cacgtcttaa ggattttgtc ccagtgtggt     3060

gccggagtat ttgaatattt taatgcaaaa tccaagcata gttggagaaa acagatagaa     3120

gaccaaatga ccaggctatg ttctccgagt tgccactctg tctccgtcaa atggcagcaa     3180

ctcaatccag atgtgcccga ggccctgcag gccccagccc aggtgccgtc cttgtttctc     3240

aatgatcgac tccttgtcta tggattcatt cctcactgca cacaggcaac tctgtgtgca     3300

ctaattcaag agaaagaatt tcgtacaatg gtgtcgacta ctgagcttca gaagacaact     3360

ggaactatga tccacaagct ggcagcccga gctctaatca gagattatga agatggcatt     3420

cttcacgaaa atgaaaccag tcatgagatg aaaaaacaaa ccttgaaatc tctgattatt     3480

aaactcagta aagaaaactc tctcataaca caatttacaa gctttgtggc agttgagaaa     3540

agggatgaga atgagtcgcc ttttcctgat attccaaaag tttctgaact tattgccaaa     3600

gaagatgtag acttcctgcc ctacatgagc tggcaggggg agccccaaga agccgtcagg     3660

aaccagtctc ttttagcatc ctctgagtgg ccagaattac gtttatccaa acgaaaacat     3720

aggaaaattc cattttccaa aagaaaaatg gaattatctc agccagaagt ttctgaagat     3780

tttgaagagg atggcttagg tgtactacca gctttcacat caaatttgga acgtggaggt     3840

gtggaaaagc tattggattt aagttggaca gagtcatgta aaccaacagc aactgaacca     3900

ctatttaaga aagtcagtcc atgggaaaca tctacttcta gcttttttcc tattttggct     3960

ccggccgttg gttcctatct tcccccgact gcccgcgctc acagtcctgc ttccttgtct     4020

tttgcctcat atcgtcaggt agctagtttc ggttcagctg ctcctcccag acagtttgat     4080

gcatctcaat tcagccaagg ccctgtgcct ggcacttgtg ctgactggat cccacagtcg     4140

gcgtcttgtc ccacaggacc tccccagaac ccaccttctt caccctattg tggcattgtt     4200

ttttcaggga gctcattaag ctctgcacag tctgctccac tgcaacatcc tggaggcttt     4260

actaccaggc cttctgctgg caccttccct gagctggatt ctccccagct tcatttctct     4320

cttcctacag accctgatcc catcagaggt tttgggtctt atcatccctc tgcttcctct     4380

ccttttcatt ttcaaccttc cgcagcctct ttgactgcca accttaggct gccaatggcc     4440

tctgctttac ctgaggctct ttgcagtcag tcccggacta ccccagtaga tctctgtctt     4500

ctagaagaat cagtaggcag tctcgaagga agtcgatgtc ctgtctttgc ttttcaaagt     4560

tctgacacag aaagtgatga gctatcagaa gtacttcaag acagctgctt tttacaaata     4620

aaatgtgata caaaagatga cagtatcctg tgctttctgg aagtaaaaga agaggatgaa     4680

atagtgtgca tacaacactg gcaggatgct gtgccttgga cagaactcct cagtctacag     4740

acagaggatg gcttctggaa acttacacca gaactgggac ttatattaaa tcttaataca     4800

aatggtttgc acagctttct taaacaaaaa ggcattcaat ctctaggtgt aaaaggaaga     4860

gaatgtctcc tggacctaat tgccacaatg ctggtactac agtttattcg caccaggttg     4920

gaaaaagagg gaatagtgtt caaatcactg atgaaaatgg atgacgcttc tatttccagg     4980

aatattccct gggcttttga ggcaataaag caagcaagtg aatgggtaag aagaactgaa     5040

ggacagtacc catctatctg cccacggctt gaactgggga acgactggga ctctgccacc     5100

aagcagttgc tgggactcca gcccataagc actgtgtccc ctcttcatag agtcctccat     5160

tacagtcaag gctaa                                                      5175


<210> 2
<211> 1724
<212> PRT
<213> Homo sapiens

<400> 2
Met Val Met Gly Ile Phe Ala Asn Cys Ile Phe Cys Leu Lys Val Lys 
1               5                   10                  15      


Tyr Leu Pro Gln Gln Gln Lys Lys Lys Leu Gln Thr Asp Ile Lys Glu 
            20                  25                  30          


Asn Gly Gly Lys Phe Ser Phe Ser Leu Asn Pro Gln Cys Thr His Ile 
        35                  40                  45              


Ile Leu Asp Asn Ala Asp Val Leu Ser Gln Tyr Gln Leu Asn Ser Ile 
    50                  55                  60                  


Gln Lys Asn His Val His Ile Ala Asn Pro Asp Phe Ile Trp Lys Ser 
65                  70                  75                  80  


Ile Arg Glu Lys Arg Leu Leu Asp Val Lys Asn Tyr Asp Pro Tyr Lys 
                85                  90                  95      


Pro Leu Asp Ile Thr Pro Pro Pro Asp Gln Lys Ala Ser Ser Ser Glu 
            100                 105                 110         


Val Lys Thr Glu Gly Leu Cys Pro Asp Ser Ala Thr Glu Glu Glu Asp 
        115                 120                 125             


Thr Val Glu Leu Thr Glu Phe Gly Met Gln Asn Val Glu Ile Pro His 
    130                 135                 140                 


Leu Pro Gln Asp Phe Glu Val Ala Lys Tyr Asn Thr Leu Glu Lys Val 
145                 150                 155                 160 


Gly Met Glu Gly Gly Gln Glu Ala Val Val Val Glu Leu Gln Cys Ser 
                165                 170                 175     


Arg Asp Ser Arg Asp Cys Pro Phe Leu Ile Ser Ser His Phe Leu Leu 
            180                 185                 190         


Asp Asp Gly Met Glu Thr Arg Arg Gln Phe Ala Ile Lys Lys Thr Ser 
        195                 200                 205             


Glu Asp Ala Ser Glu Tyr Phe Glu Asn Tyr Ile Glu Glu Leu Lys Lys 
    210                 215                 220                 


Gln Gly Phe Leu Leu Arg Glu His Phe Thr Pro Glu Ala Thr Gln Leu 
225                 230                 235                 240 


Ala Ser Glu Gln Leu Gln Ala Leu Leu Leu Glu Glu Val Met Asn Ser 
                245                 250                 255     


Ser Thr Leu Ser Gln Glu Val Ser Asp Leu Val Glu Met Ile Trp Ala 
            260                 265                 270         


Glu Ala Leu Gly His Leu Glu His Met Leu Leu Lys Pro Val Asn Arg 
        275                 280                 285             


Ile Ser Leu Asn Asp Val Ser Lys Ala Glu Gly Ile Leu Leu Leu Val 
    290                 295                 300                 


Lys Ala Ala Leu Lys Asn Gly Glu Thr Ala Glu Gln Leu Gln Lys Met 
305                 310                 315                 320 


Met Thr Glu Phe Tyr Arg Leu Ile Pro His Lys Gly Thr Met Pro Lys 
                325                 330                 335     


Glu Val Asn Leu Gly Leu Leu Ala Lys Lys Ala Asp Leu Cys Gln Leu 
            340                 345                 350         


Ile Arg Asp Met Val Asn Val Cys Glu Thr Asn Leu Ser Lys Pro Asn 
        355                 360                 365             


Pro Pro Ser Leu Ala Lys Tyr Arg Ala Leu Arg Cys Lys Ile Glu His 
    370                 375                 380                 


Val Glu Gln Asn Thr Glu Glu Phe Leu Arg Val Arg Lys Glu Val Leu 
385                 390                 395                 400 


Gln Asn His His Ser Lys Ser Pro Val Asp Val Leu Gln Ile Phe Arg 
                405                 410                 415     


Val Gly Arg Val Asn Glu Thr Thr Glu Phe Leu Ser Lys Leu Gly Asn 
            420                 425                 430         


Val Arg Pro Leu Leu His Gly Ser Pro Val Gln Asn Ile Val Gly Ile 
        435                 440                 445             


Leu Cys Arg Gly Leu Leu Leu Pro Lys Val Val Glu Asp Arg Gly Val 
    450                 455                 460                 


Gln Arg Thr Asp Val Gly Asn Leu Gly Ser Gly Ile Tyr Phe Ser Asp 
465                 470                 475                 480 


Ser Leu Ser Thr Ser Ile Lys Tyr Ser His Pro Gly Glu Thr Asp Gly 
                485                 490                 495     


Thr Arg Leu Leu Leu Ile Cys Asp Val Ala Leu Gly Lys Cys Met Asp 
            500                 505                 510         


Leu His Glu Lys Asp Phe Ser Leu Thr Glu Ala Pro Pro Gly Tyr Asp 
        515                 520                 525             


Ser Val His Gly Val Ser Gln Thr Ala Ser Val Thr Thr Asp Phe Glu 
    530                 535                 540                 


Asp Asp Glu Phe Val Val Tyr Lys Thr Asn Gln Val Lys Met Lys Tyr 
545                 550                 555                 560 


Ile Ile Lys Phe Ser Met Pro Gly Asp Gln Ile Lys Asp Phe His Pro 
                565                 570                 575     


Ser Asp His Thr Glu Leu Glu Glu Tyr Arg Pro Glu Phe Ser Asn Phe 
            580                 585                 590         


Ser Lys Val Glu Asp Tyr Gln Leu Pro Asp Ala Lys Thr Ser Ser Ser 
        595                 600                 605             


Thr Lys Ala Gly Leu Gln Asp Ala Ser Gly Asn Leu Val Pro Leu Glu 
    610                 615                 620                 


Asp Val His Ile Lys Gly Arg Ile Ile Asp Thr Val Ala Gln Val Ile 
625                 630                 635                 640 


Val Phe Gln Thr Tyr Thr Asn Lys Ser His Val Pro Ile Glu Ala Lys 
                645                 650                 655     


Tyr Ile Phe Pro Leu Asp Asp Lys Ala Ala Val Cys Gly Phe Glu Ala 
            660                 665                 670         


Phe Ile Asn Gly Lys His Ile Val Gly Glu Ile Lys Glu Lys Glu Glu 
        675                 680                 685             


Ala Gln Gln Glu Tyr Leu Glu Ala Val Thr Gln Gly His Gly Ala Tyr 
    690                 695                 700                 


Leu Met Ser Gln Asp Ala Pro Asp Val Phe Thr Val Ser Val Gly Asn 
705                 710                 715                 720 


Leu Pro Pro Lys Ala Lys Val Leu Ile Lys Ile Thr Tyr Ile Thr Glu 
                725                 730                 735     


Leu Ser Ile Leu Gly Thr Val Gly Val Phe Phe Met Pro Ala Thr Val 
            740                 745                 750         


Ala Pro Trp Gln Gln Asp Lys Ala Leu Asn Glu Asn Leu Gln Asp Thr 
        755                 760                 765             


Val Glu Lys Ile Cys Ile Lys Glu Ile Gly Thr Lys Gln Ser Phe Ser 
    770                 775                 780                 


Leu Thr Met Ser Ile Glu Met Pro Tyr Val Ile Glu Phe Ile Phe Ser 
785                 790                 795                 800 


Asp Thr His Glu Leu Lys Gln Lys Arg Thr Asp Cys Lys Ala Val Ile 
                805                 810                 815     


Ser Thr Met Glu Gly Ser Ser Leu Asp Ser Ser Gly Phe Ser Leu His 
            820                 825                 830         


Ile Gly Leu Ser Ala Ala Tyr Leu Pro Arg Met Trp Val Glu Lys His 
        835                 840                 845             


Pro Glu Lys Glu Ser Glu Ala Cys Met Leu Val Phe Gln Pro Asp Leu 
    850                 855                 860                 


Asp Val Asp Leu Pro Asp Leu Ala Ser Glu Ser Glu Val Ile Ile Cys 
865                 870                 875                 880 


Leu Asp Cys Ser Ser Ser Met Glu Gly Val Thr Phe Leu Gln Ala Lys 
                885                 890                 895     


Gln Ile Ala Leu His Ala Leu Ser Leu Val Gly Glu Lys Gln Lys Val 
            900                 905                 910         


Asn Ile Ile Gln Phe Gly Thr Gly Tyr Lys Glu Leu Phe Ser Tyr Pro 
        915                 920                 925             


Lys His Ile Thr Ser Asn Thr Met Ala Ala Glu Phe Ile Met Ser Ala 
    930                 935                 940                 


Thr Pro Thr Met Gly Asn Thr Asp Phe Trp Lys Thr Leu Arg Tyr Leu 
945                 950                 955                 960 


Ser Leu Leu Tyr Pro Ala Arg Gly Ser Arg Asn Ile Leu Leu Val Ser 
                965                 970                 975     


Asp Gly His Leu Gln Asp Glu Ser Leu Thr Leu Gln Leu Val Lys Arg 
            980                 985                 990         


Ser Arg Pro His Thr Arg Leu Phe  Ala Cys Gly Ile Gly  Ser Thr Ala 
        995                 1000                 1005             


Asn Arg  His Val Leu Arg Ile  Leu Ser Gln Cys Gly  Ala Gly Val 
    1010                 1015                 1020             


Phe Glu  Tyr Phe Asn Ala Lys  Ser Lys His Ser Trp  Arg Lys Gln 
    1025                 1030                 1035             


Ile Glu  Asp Gln Met Thr Arg  Leu Cys Ser Pro Ser  Cys His Ser 
    1040                 1045                 1050             


Val Ser  Val Lys Trp Gln Gln  Leu Asn Pro Asp Val  Pro Glu Ala 
    1055                 1060                 1065             


Leu Gln  Ala Pro Ala Gln Val  Pro Ser Leu Phe Leu  Asn Asp Arg 
    1070                 1075                 1080             


Leu Leu  Val Tyr Gly Phe Ile  Pro His Cys Thr Gln  Ala Thr Leu 
    1085                 1090                 1095             


Cys Ala  Leu Ile Gln Glu Lys  Glu Phe Arg Thr Met  Val Ser Thr 
    1100                 1105                 1110             


Thr Glu  Leu Gln Lys Thr Thr  Gly Thr Met Ile His  Lys Leu Ala 
    1115                 1120                 1125             


Ala Arg  Ala Leu Ile Arg Asp  Tyr Glu Asp Gly Ile  Leu His Glu 
    1130                 1135                 1140             


Asn Glu  Thr Ser His Glu Met  Lys Lys Gln Thr Leu  Lys Ser Leu 
    1145                 1150                 1155             


Ile Ile  Lys Leu Ser Lys Glu  Asn Ser Leu Ile Thr  Gln Phe Thr 
    1160                 1165                 1170             


Ser Phe  Val Ala Val Glu Lys  Arg Asp Glu Asn Glu  Ser Pro Phe 
    1175                 1180                 1185             


Pro Asp  Ile Pro Lys Val Ser  Glu Leu Ile Ala Lys  Glu Asp Val 
    1190                 1195                 1200             


Asp Phe  Leu Pro Tyr Met Ser  Trp Gln Gly Glu Pro  Gln Glu Ala 
    1205                 1210                 1215             


Val Arg  Asn Gln Ser Leu Leu  Ala Ser Ser Glu Trp  Pro Glu Leu 
    1220                 1225                 1230             


Arg Leu  Ser Lys Arg Lys His  Arg Lys Ile Pro Phe  Ser Lys Arg 
    1235                 1240                 1245             


Lys Met  Glu Leu Ser Gln Pro  Glu Val Ser Glu Asp  Phe Glu Glu 
    1250                 1255                 1260             


Asp Gly  Leu Gly Val Leu Pro  Ala Phe Thr Ser Asn  Leu Glu Arg 
    1265                 1270                 1275             


Gly Gly  Val Glu Lys Leu Leu  Asp Leu Ser Trp Thr  Glu Ser Cys 
    1280                 1285                 1290             


Lys Pro  Thr Ala Thr Glu Pro  Leu Phe Lys Lys Val  Ser Pro Trp 
    1295                 1300                 1305             


Glu Thr  Ser Thr Ser Ser Phe  Phe Pro Ile Leu Ala  Pro Ala Val 
    1310                 1315                 1320             


Gly Ser  Tyr Leu Pro Pro Thr  Ala Arg Ala His Ser  Pro Ala Ser 
    1325                 1330                 1335             


Leu Ser  Phe Ala Ser Tyr Arg  Gln Val Ala Ser Phe  Gly Ser Ala 
    1340                 1345                 1350             


Ala Pro  Pro Arg Gln Phe Asp  Ala Ser Gln Phe Ser  Gln Gly Pro 
    1355                 1360                 1365             


Val Pro  Gly Thr Cys Ala Asp  Trp Ile Pro Gln Ser  Ala Ser Cys 
    1370                 1375                 1380             


Pro Thr  Gly Pro Pro Gln Asn  Pro Pro Ser Ser Pro  Tyr Cys Gly 
    1385                 1390                 1395             


Ile Val  Phe Ser Gly Ser Ser  Leu Ser Ser Ala Gln  Ser Ala Pro 
    1400                 1405                 1410             


Leu Gln  His Pro Gly Gly Phe  Thr Thr Arg Pro Ser  Ala Gly Thr 
    1415                 1420                 1425             


Phe Pro  Glu Leu Asp Ser Pro  Gln Leu His Phe Ser  Leu Pro Thr 
    1430                 1435                 1440             


Asp Pro  Asp Pro Ile Arg Gly  Phe Gly Ser Tyr His  Pro Ser Ala 
    1445                 1450                 1455             


Ser Ser  Pro Phe His Phe Gln  Pro Ser Ala Ala Ser  Leu Thr Ala 
    1460                 1465                 1470             


Asn Leu  Arg Leu Pro Met Ala  Ser Ala Leu Pro Glu  Ala Leu Cys 
    1475                 1480                 1485             


Ser Gln  Ser Arg Thr Thr Pro  Val Asp Leu Cys Leu  Leu Glu Glu 
    1490                 1495                 1500             


Ser Val  Gly Ser Leu Glu Gly  Ser Arg Cys Pro Val  Phe Ala Phe 
    1505                 1510                 1515             


Gln Ser  Ser Asp Thr Glu Ser  Asp Glu Leu Ser Glu  Val Leu Gln 
    1520                 1525                 1530             


Asp Ser  Cys Phe Leu Gln Ile  Lys Cys Asp Thr Lys  Asp Asp Ser 
    1535                 1540                 1545             


Ile Leu  Cys Phe Leu Glu Val  Lys Glu Glu Asp Glu  Ile Val Cys 
    1550                 1555                 1560             


Ile Gln  His Trp Gln Asp Ala  Val Pro Trp Thr Glu  Leu Leu Ser 
    1565                 1570                 1575             


Leu Gln  Thr Glu Asp Gly Phe  Trp Lys Leu Thr Pro  Glu Leu Gly 
    1580                 1585                 1590             


Leu Ile  Leu Asn Leu Asn Thr  Asn Gly Leu His Ser  Phe Leu Lys 
    1595                 1600                 1605             


Gln Lys  Gly Ile Gln Ser Leu  Gly Val Lys Gly Arg  Glu Cys Leu 
    1610                 1615                 1620             


Leu Asp  Leu Ile Ala Thr Met  Leu Val Leu Gln Phe  Ile Arg Thr 
    1625                 1630                 1635             


Arg Leu  Glu Lys Glu Gly Ile  Val Phe Lys Ser Leu  Met Lys Met 
    1640                 1645                 1650             


Asp Asp  Ala Ser Ile Ser Arg  Asn Ile Pro Trp Ala  Phe Glu Ala 
    1655                 1660                 1665             


Ile Lys  Gln Ala Ser Glu Trp  Val Arg Arg Thr Glu  Gly Gln Tyr 
    1670                 1675                 1680             


Pro Ser  Ile Cys Pro Arg Leu  Glu Leu Gly Asn Asp  Trp Asp Ser 
    1685                 1690                 1695             


Ala Thr  Lys Gln Leu Leu Gly  Leu Gln Pro Ile Ser  Thr Val Ser 
    1700                 1705                 1710             


Pro Leu  His Arg Val Leu His  Tyr Ser Gln Gly 
    1715                 1720                 


<210> 3
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gln Trp Ala Val Gly His Leu Met 
1               5               


<210> 4
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
ctgaagacac aggtagcgag tgggcggtgg ggcacttaat ggctcctgat ggcacac          57


<210> 5
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
gtgtgccatc aggagccatt aagtgcccca ccgcccactc gctacctgtg tcttcag          57


<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210> 7
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
ctgaagacac aggtagcgat tacaaagatg acgatgataa ggctcctgat ggcacac          57


<210> 8
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
gtgtgccatc aggagcctta tcatcgtcat ctttgtaatc gctacctgtg tcttcag          57


<210> 9
<211> 861
<212> PRT
<213> Rattus norvegicus

<400> 9
Met Ala Thr Glu Glu Ala Ile Ile Arg Ile Pro Pro Tyr His Tyr Ile 
1               5                   10                  15      


His Val Leu Asp Gln Asn Ser Asn Val Ser Arg Val Glu Val Gly Pro 
            20                  25                  30          


Lys Thr Tyr Ile Arg Gln Asp Asn Glu Arg Val Leu Phe Ala Pro Val 
        35                  40                  45              


Arg Met Val Thr Val Pro Pro Arg His Tyr Cys Ile Val Ala Asn Pro 
    50                  55                  60                  


Val Ser Arg Asp Thr Gln Ser Ser Val Leu Phe Asp Ile Thr Gly Gln 
65                  70                  75                  80  


Val Arg Leu Arg His Ala Asp Gln Glu Ile Arg Leu Ala Gln Asp Pro 
                85                  90                  95      


Phe Pro Leu Tyr Pro Gly Glu Val Leu Glu Lys Asp Ile Thr Pro Leu 
            100                 105                 110         


Gln Val Val Leu Pro Asn Thr Ala Leu His Leu Lys Ala Leu Leu Asp 
        115                 120                 125             


Phe Glu Asp Lys Asn Gly Asp Lys Val Met Ala Gly Asp Glu Trp Leu 
    130                 135                 140                 


Phe Glu Gly Pro Gly Thr Tyr Ile Pro Gln Lys Glu Val Glu Val Val 
145                 150                 155                 160 


Glu Ile Ile Gln Ala Thr Val Ile Lys Gln Asn Gln Ala Leu Arg Leu 
                165                 170                 175     


Arg Ala Arg Lys Glu Cys Phe Asp Arg Glu Gly Lys Gly Arg Val Thr 
            180                 185                 190         


Gly Glu Glu Trp Leu Val Arg Ser Val Gly Ala Tyr Leu Pro Ala Val 
        195                 200                 205             


Phe Glu Glu Val Leu Asp Leu Val Asp Ala Val Ile Leu Thr Glu Lys 
    210                 215                 220                 


Thr Ala Leu His Leu Arg Ala Leu Gln Asn Phe Arg Asp Leu Arg Gly 
225                 230                 235                 240 


Val Leu His Arg Thr Gly Glu Glu Trp Leu Val Thr Val Gln Asp Thr 
                245                 250                 255     


Glu Ala His Val Pro Asp Val Tyr Glu Glu Val Leu Gly Val Val Pro 
            260                 265                 270         


Ile Thr Thr Leu Gly Pro Arg His Tyr Cys Val Ile Leu Asp Pro Met 
        275                 280                 285             


Gly Pro Asp Gly Lys Asn Gln Leu Gly Gln Lys Arg Val Val Lys Gly 
    290                 295                 300                 


Glu Lys Ser Phe Phe Leu Gln Pro Gly Glu Arg Leu Glu Arg Gly Ile 
305                 310                 315                 320 


Gln Asp Val Tyr Val Leu Ser Glu Gln Gln Gly Leu Leu Leu Lys Ala 
                325                 330                 335     


Leu Gln Pro Leu Glu Glu Gly Glu Ser Glu Glu Lys Val Ser His Gln 
            340                 345                 350         


Ala Gly Asp Cys Trp Leu Ile Arg Gly Pro Leu Glu Tyr Val Pro Ser 
        355                 360                 365             


Ala Lys Val Glu Val Val Glu Glu Arg Gln Ala Ile Pro Leu Asp Gln 
    370                 375                 380                 


Asn Glu Gly Ile Tyr Val Gln Asp Val Lys Thr Gly Lys Val Arg Ala 
385                 390                 395                 400 


Val Ile Gly Ser Thr Tyr Met Leu Thr Gln Asp Glu Val Leu Trp Glu 
                405                 410                 415     


Lys Glu Leu Pro Ser Gly Val Glu Glu Leu Leu Asn Leu Gly His Asp 
            420                 425                 430         


Pro Leu Ala Asp Arg Gly Gln Lys Gly Thr Ala Lys Pro Leu Gln Pro 
        435                 440                 445             


Ser Ala Pro Arg Asn Lys Thr Arg Val Val Ser Tyr Arg Val Pro His 
    450                 455                 460                 


Asn Ala Ala Val Gln Val Tyr Asp Tyr Arg Ala Lys Arg Ala Arg Val 
465                 470                 475                 480 


Val Phe Gly Pro Glu Leu Val Thr Leu Asp Pro Glu Glu Gln Phe Thr 
                485                 490                 495     


Val Leu Ser Leu Ser Ala Gly Arg Pro Lys Arg Pro His Ala Arg Arg 
            500                 505                 510         


Ala Leu Cys Leu Leu Leu Gly Pro Asp Phe Phe Thr Asp Val Ile Thr 
        515                 520                 525             


Ile Glu Thr Ala Asp His Ala Arg Leu Gln Leu Gln Leu Ala Tyr Asn 
    530                 535                 540                 


Trp His Phe Glu Leu Lys Asn Arg Asn Asp Pro Ala Glu Ala Ala Lys 
545                 550                 555                 560 


Leu Phe Ser Val Pro Asp Phe Val Gly Asp Ala Cys Lys Ala Ile Ala 
                565                 570                 575     


Ser Arg Val Arg Gly Ala Val Ala Ser Val Thr Phe Asp Asp Phe His 
            580                 585                 590         


Lys Asn Ser Ala Arg Ile Ile Arg Met Ala Val Phe Gly Phe Glu Met 
        595                 600                 605             


Ser Glu Asp Thr Gly Pro Asp Gly Thr Leu Leu Pro Lys Ala Arg Asp 
    610                 615                 620                 


Gln Ala Val Phe Pro Gln Asn Gly Leu Val Val Ser Ser Val Asp Val 
625                 630                 635                 640 


Gln Ser Val Glu Pro Val Asp Gln Arg Thr Arg Asp Ala Leu Gln Arg 
                645                 650                 655     


Ser Val Gln Leu Ala Ile Glu Ile Thr Thr Asn Ser Gln Glu Ala Ala 
            660                 665                 670         


Ala Lys His Glu Ala Gln Arg Leu Glu Gln Glu Ala Arg Gly Arg Leu 
        675                 680                 685             


Glu Arg Gln Lys Ile Leu Asp Gln Ser Glu Ala Glu Lys Ala Arg Lys 
    690                 695                 700                 


Glu Leu Leu Glu Leu Glu Ala Met Ser Met Ala Val Glu Ser Thr Gly 
705                 710                 715                 720 


Asn Ala Lys Ala Glu Ala Glu Ser Arg Ala Glu Ala Ala Arg Ile Glu 
                725                 730                 735     


Gly Glu Gly Ser Val Leu Gln Ala Lys Leu Lys Ala Gln Ala Leu Ala 
            740                 745                 750         


Ile Glu Thr Glu Ala Glu Leu Glu Arg Val Lys Lys Val Arg Glu Met 
        755                 760                 765             


Glu Leu Ile Tyr Ala Arg Ala Gln Leu Glu Leu Glu Val Ser Lys Ala 
    770                 775                 780                 


Gln Gln Leu Ala Asn Val Glu Ala Lys Lys Phe Lys Glu Met Thr Glu 
785                 790                 795                 800 


Ala Leu Gly Pro Gly Thr Ile Arg Asp Leu Ala Val Ala Gly Pro Glu 
                805                 810                 815     


Met Gln Val Lys Leu Leu Gln Ser Leu Gly Leu Lys Ser Thr Leu Ile 
            820                 825                 830         


Thr Asp Gly Ser Ser Pro Ile Asn Leu Phe Ser Thr Ala Phe Gly Leu 
        835                 840                 845             


Leu Gly Leu Gly Ser Asp Gly Gln Pro Pro Ala Gln Lys 
    850                 855                 860     


<210> 10
<211> 893
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Thr Glu Glu Phe Ile Ile Arg Ile Pro Pro Tyr His Tyr Ile 
1               5                   10                  15      


His Val Leu Asp Gln Asn Ser Asn Val Ser Arg Val Glu Val Gly Pro 
            20                  25                  30          


Lys Thr Tyr Ile Arg Gln Asp Asn Glu Arg Val Leu Phe Ala Pro Met 
        35                  40                  45              


Arg Met Val Thr Val Pro Pro Arg His Tyr Cys Thr Val Ala Asn Pro 
    50                  55                  60                  


Val Ser Arg Asp Ala Gln Gly Leu Val Leu Phe Asp Val Thr Gly Gln 
65                  70                  75                  80  


Val Arg Leu Arg His Ala Asp Leu Glu Ile Arg Leu Ala Gln Asp Pro 
                85                  90                  95      


Phe Pro Leu Tyr Pro Gly Glu Val Leu Glu Lys Asp Ile Thr Pro Leu 
            100                 105                 110         


Gln Val Val Leu Pro Asn Thr Ala Leu His Leu Lys Ala Leu Leu Asp 
        115                 120                 125             


Phe Glu Asp Lys Asp Gly Asp Lys Val Val Ala Gly Asp Glu Trp Leu 
    130                 135                 140                 


Phe Glu Gly Pro Gly Thr Tyr Ile Pro Arg Lys Glu Val Glu Val Val 
145                 150                 155                 160 


Glu Ile Ile Gln Ala Thr Ile Ile Arg Gln Asn Gln Ala Leu Arg Leu 
                165                 170                 175     


Arg Ala Arg Lys Glu Cys Trp Asp Arg Asp Gly Lys Glu Arg Val Thr 
            180                 185                 190         


Gly Glu Glu Trp Leu Val Thr Thr Val Gly Ala Tyr Leu Pro Ala Val 
        195                 200                 205             


Phe Glu Glu Val Leu Asp Leu Val Asp Ala Val Ile Leu Thr Glu Lys 
    210                 215                 220                 


Thr Ala Leu His Leu Arg Ala Arg Arg Asn Phe Arg Asp Phe Arg Gly 
225                 230                 235                 240 


Val Ser Arg Arg Thr Gly Glu Glu Trp Leu Val Thr Val Gln Asp Thr 
                245                 250                 255     


Glu Ala His Val Pro Asp Val His Glu Glu Val Leu Gly Val Val Pro 
            260                 265                 270         


Ile Thr Thr Leu Gly Pro His Asn Tyr Cys Val Ile Leu Asp Pro Val 
        275                 280                 285             


Gly Pro Asp Gly Lys Asn Gln Leu Gly Gln Lys Arg Val Val Lys Gly 
    290                 295                 300                 


Glu Lys Ser Phe Phe Leu Gln Pro Gly Glu Gln Leu Glu Gln Gly Ile 
305                 310                 315                 320 


Gln Asp Val Tyr Val Leu Ser Glu Gln Gln Gly Leu Leu Leu Arg Ala 
                325                 330                 335     


Leu Gln Pro Leu Glu Glu Gly Glu Asp Glu Glu Lys Val Ser His Gln 
            340                 345                 350         


Ala Gly Asp His Trp Leu Ile Arg Gly Pro Leu Glu Tyr Val Pro Ser 
        355                 360                 365             


Ala Lys Val Glu Val Val Glu Glu Arg Gln Ala Ile Pro Leu Asp Glu 
    370                 375                 380                 


Asn Glu Gly Ile Tyr Val Gln Asp Val Lys Thr Gly Lys Val Arg Ala 
385                 390                 395                 400 


Val Ile Gly Ser Thr Tyr Met Leu Thr Gln Asp Glu Val Leu Trp Glu 
                405                 410                 415     


Lys Glu Leu Pro Pro Gly Val Glu Glu Leu Leu Asn Lys Gly Gln Asp 
            420                 425                 430         


Pro Leu Ala Asp Arg Gly Glu Lys Asp Thr Ala Lys Ser Leu Gln Pro 
        435                 440                 445             


Leu Ala Pro Arg Asn Lys Thr Arg Val Val Ser Tyr Arg Val Pro His 
    450                 455                 460                 


Asn Ala Ala Val Gln Val Tyr Asp Tyr Arg Glu Lys Arg Ala Arg Val 
465                 470                 475                 480 


Val Phe Gly Pro Glu Leu Val Ser Leu Gly Pro Glu Glu Gln Phe Thr 
                485                 490                 495     


Val Leu Ser Leu Ser Ala Gly Arg Pro Lys Arg Pro His Ala Arg Arg 
            500                 505                 510         


Ala Leu Cys Leu Leu Leu Gly Pro Asp Phe Phe Thr Asp Val Ile Thr 
        515                 520                 525             


Ile Glu Thr Ala Asp His Ala Arg Leu Gln Leu Gln Leu Ala Tyr Asn 
    530                 535                 540                 


Trp His Phe Glu Val Asn Asp Arg Lys Asp Pro Gln Glu Thr Ala Lys 
545                 550                 555                 560 


Leu Phe Ser Val Pro Asp Phe Val Gly Asp Ala Cys Lys Ala Ile Ala 
                565                 570                 575     


Ser Arg Val Arg Gly Ala Val Ala Ser Val Thr Phe Asp Asp Phe His 
            580                 585                 590         


Lys Asn Ser Ala Arg Ile Ile Arg Thr Ala Val Phe Gly Phe Glu Thr 
        595                 600                 605             


Ser Glu Ala Lys Gly Pro Asp Gly Met Ala Leu Pro Arg Pro Arg Asp 
    610                 615                 620                 


Gln Ala Val Phe Pro Gln Asn Gly Leu Val Val Ser Ser Val Asp Val 
625                 630                 635                 640 


Gln Ser Val Glu Pro Val Asp Gln Arg Thr Arg Asp Ala Leu Gln Arg 
                645                 650                 655     


Ser Val Gln Leu Ala Ile Glu Ile Thr Thr Asn Ser Gln Glu Ala Ala 
            660                 665                 670         


Ala Lys His Glu Ala Gln Arg Leu Glu Gln Glu Ala Arg Gly Arg Leu 
        675                 680                 685             


Glu Arg Gln Lys Ile Leu Asp Gln Ser Glu Ala Glu Lys Ala Arg Lys 
    690                 695                 700                 


Glu Leu Leu Glu Leu Glu Ala Leu Ser Met Ala Val Glu Ser Thr Gly 
705                 710                 715                 720 


Thr Ala Lys Ala Glu Ala Glu Ser Arg Ala Glu Ala Ala Arg Ile Glu 
                725                 730                 735     


Gly Glu Gly Ser Val Leu Gln Ala Lys Leu Lys Ala Gln Ala Leu Ala 
            740                 745                 750         


Ile Glu Thr Glu Ala Glu Leu Gln Arg Val Gln Lys Val Arg Glu Leu 
        755                 760                 765             


Glu Leu Val Tyr Ala Arg Ala Gln Leu Glu Leu Glu Val Ser Lys Ala 
    770                 775                 780                 


Gln Gln Leu Ala Glu Val Glu Val Lys Lys Phe Lys Gln Met Thr Glu 
785                 790                 795                 800 


Ala Ile Gly Pro Ser Thr Ile Arg Asp Leu Ala Val Ala Gly Pro Glu 
                805                 810                 815     


Met Gln Val Lys Leu Leu Gln Ser Leu Gly Leu Lys Ser Thr Leu Ile 
            820                 825                 830         


Thr Asp Gly Ser Thr Pro Ile Asn Leu Phe Asn Thr Ala Phe Gly Leu 
        835                 840                 845             


Leu Gly Met Gly Pro Glu Gly Gln Pro Leu Gly Arg Arg Val Ala Ser 
    850                 855                 860                 


Gly Pro Ser Pro Gly Glu Gly Ile Ser Pro Gln Ser Ala Gln Ala Pro 
865                 870                 875                 880 


Gln Ala Pro Gly Asp Asn His Val Val Pro Val Leu Arg 
                885                 890             


<210> 11
<211> 45
<212> DNA
<213> Rattus norvegicus


<220>
<221> CDS
<222> (1)..(45)

<400> 11
gag atg tct gaa gac aca ggt cct gat ggc aca ctc ctg ccc aag             45
Glu Met Ser Glu Asp Thr Gly Pro Asp Gly Thr Leu Leu Pro Lys               
1               5                   10                  15                


<210> 12
<211> 15
<212> PRT
<213> Rattus norvegicus

<400> 12
Glu Met Ser Glu Asp Thr Gly Pro Asp Gly Thr Leu Leu Pro Lys 
1               5                   10                  15  


<210> 13
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> CDS
<222> (1)..(51)

<400> 13
gag atg tct gaa gac aca ggt agc gct cct gat ggc aca ctc ctg ccc         48
Glu Met Ser Glu Asp Thr Gly Ser Ala Pro Asp Gly Thr Leu Leu Pro           
1               5                   10                  15                

aag                                                                     51
Lys                                                                       
                                                                          


<210> 14
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Glu Met Ser Glu Asp Thr Gly Ser Ala Pro Asp Gly Thr Leu Leu Pro 
1               5                   10                  15      


Lys 
    


<210> 15
<211> 12
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> CDS
<222> (1)..(12)

<400> 15
gag agc gct aag                                                         12
Glu Ser Ala Lys                                                           
1                                                                         


<210> 16
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Glu Ser Ala Lys 
1               


<210> 17
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> CDS
<222> (1)..(24)

<400> 17
gag atg tct gaa gac aca ggt agc                                         24
Glu Met Ser Glu Asp Thr Gly Ser                                           
1               5                                                         


<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Glu Met Ser Glu Asp Thr Gly Ser 
1               5               


<210> 19
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> CDS
<222> (1)..(27)

<400> 19
gct cct gat ggc aca ctc ctg ccc aag                                     27
Ala Pro Asp Gly Thr Leu Leu Pro Lys                                       
1               5                                                         


<210> 20
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Ala Pro Asp Gly Thr Leu Leu Pro Lys 
1               5                   


