                         SEQUENCE LISTING

<110>  UBI IP Holdings
       UBI US Holdings, LLC
       Wang, Chang Yi
 
<120>  PEPTIDE IMMUNOGENS OF IL-31 AND FORMULATIONS THEREOF FOR THE 
       TREATMENT AND/OR PREVENTION OF ATOPIC DERMATITIS

<130>  2037-WO

<140>  TBD
<141>  2018-12-11

<150>  US 62/597,130
<151>  2017-12-11

<160>  110   

<170>  PatentIn version 3.5

<210>  1
<211>  159
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(159)
<223>  Canine IL-31 1-159 (Uniprot C7G0W1-1; GenBank: BAH97742.1)

<400>  1

Met Leu Ser His Thr Gly Pro Ser Arg Phe Ala Leu Phe Leu Leu Cys 
1               5                   10                  15      


Ser Met Glu Thr Leu Leu Ser Ser His Met Ala Pro Thr His Gln Leu 
            20                  25                  30          


Pro Pro Ser Asp Val Arg Lys Ile Ile Leu Glu Leu Gln Pro Leu Ser 
        35                  40                  45              


Arg Gly Leu Leu Glu Asp Tyr Gln Lys Lys Glu Thr Gly Val Pro Glu 
    50                  55                  60                  


Ser Asn Arg Thr Leu Leu Leu Cys Leu Thr Ser Asp Ser Gln Pro Pro 
65                  70                  75                  80  


Arg Leu Asn Ser Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro 
                85                  90                  95      


Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 
            100                 105                 110         


Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp 
        115                 120                 125             


Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
    130                 135                 140                 


Ala Cys Leu Glu Ser Val Phe Lys Ser Leu Asn Ser Gly Pro Gln 
145                 150                 155                 


<210>  2
<211>  164
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(164)
<223>  Human IL-31 1-164 (GenBank: AAS86448.1)

<400>  2

Met Ala Ser His Ser Gly Pro Ser Thr Ser Val Leu Phe Leu Phe Cys 
1               5                   10                  15      


Cys Leu Gly Gly Trp Leu Ala Ser His Thr Leu Pro Val Arg Leu Leu 
            20                  25                  30          


Arg Pro Ser Asp Asp Val Gln Lys Ile Val Glu Glu Leu Gln Ser Leu 
        35                  40                  45              


Ser Lys Met Leu Leu Lys Asp Val Glu Glu Glu Lys Gly Val Leu Val 
    50                  55                  60                  


Ser Gln Asn Tyr Thr Leu Pro Cys Leu Ser Pro Asp Ala Gln Pro Pro 
65                  70                  75                  80  


Asn Asn Ile His Ser Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg 
                85                  90                  95      


Gln Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp 
            100                 105                 110         


Lys Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr 
        115                 120                 125             


Asp Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe 
    130                 135                 140                 


Ser Glu Cys Met Asp Leu Ala Leu Lys Ser Leu Thr Ser Gly Ala Gln 
145                 150                 155                 160 


Gln Ala Thr Thr 
                


<210>  3
<211>  48
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(48)
<223>  canine IL-31 97-144

<400>  3

Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 
1               5                   10                  15      


Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp 
            20                  25                  30          


Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
        35                  40                  45              


<210>  4
<211>  37
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(37)
<223>  canine IL-31 97-133

<400>  4

Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 
1               5                   10                  15      


Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp 
            20                  25                  30          


Thr Phe Glu Cys Lys 
        35          


<210>  5
<211>  26
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(26)
<223>  canine IL-31 97-122

<400>  5

Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 
1               5                   10                  15      


Leu Lys Phe Gln His Glu Pro Glu Thr Glu 
            20                  25      


<210>  6
<211>  18
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  canine IL-31 97-114

<400>  6

Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 
1               5                   10                  15      


Leu Lys 
        


<210>  7
<211>  21
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  canine IL-31 90-110

<400>  7

Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp Lys 
1               5                   10                  15      


Ile Ile Glu Gln Leu 
            20      


<210>  8
<211>  55
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(55)
<223>  canine IL-31 90-144

<400>  8

Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp Lys 
1               5                   10                  15      


Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr 
            20                  25                  30          


Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu 
        35                  40                  45              


Thr Ile Leu Gln Gln Phe Ser 
    50                  55  


<210>  9
<211>  59
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(59)
<223>  canine IL-31 86-144

<400>  9

Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn 
1               5                   10                  15      


Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His 
            20                  25                  30          


Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys 
        35                  40                  45              


Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
    50                  55                  


<210>  10
<211>  53
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(53)
<223>  canine IL-31 97-149, C146 to S146

<400>  10

Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys 
1               5                   10                  15      


Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp 
            20                  25                  30          


Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
        35                  40                  45              


Ala Ser Leu Glu Ser 
    50              


<210>  11
<211>  60
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(60)
<223>  canine IL-31 90-149, C146 to S146

<400>  11

Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp Lys 
1               5                   10                  15      


Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr 
            20                  25                  30          


Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu 
        35                  40                  45              


Thr Ile Leu Gln Gln Phe Ser Ala Ser Leu Glu Ser 
    50                  55                  60  


<210>  12
<211>  64
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(64)
<223>  canine IL-31 86-149, C146 to S146

<400>  12

Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn 
1               5                   10                  15      


Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His 
            20                  25                  30          


Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys 
        35                  40                  45              


Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser Ala Ser Leu Glu Ser 
    50                  55                  60                  


<210>  13
<211>  48
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(48)
<223>  human IL-31 98-145

<400>  13

Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys 
1               5                   10                  15      


Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp 
            20                  25                  30          


Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser 
        35                  40                  45              


<210>  14
<211>  17
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  Clostridium tetani 1 Th

<400>  14

Lys Lys Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  15      


Leu 
    


<210>  15
<211>  15
<212>  PRT
<213>  Measles virus


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  MvF1 Th

<400>  15

Leu Ser Glu Ile Lys Gly Val Ile Val His Arg Leu Glu Gly Val 
1               5                   10                  15  


<210>  16
<211>  24
<212>  PRT
<213>  Bordetella pertussis


<220>
<221>  PEPTIDE
<222>  (1)..(24)
<223>  Bordetella pertussis Th

<400>  16

Gly Ala Tyr Ala Arg Cys Pro Asn Gly Thr Arg Ala Leu Thr Val Ala 
1               5                   10                  15      


Glu Leu Arg Gly Asn Ala Glu Leu 
            20                  


<210>  17
<211>  17
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  Clostridium tetani 2 Th

<400>  17

Trp Val Arg Asp Ile Ile Asp Asp Phe Thr Asn Glu Ser Ser Gln Lys 
1               5                   10                  15      


Thr 
    


<210>  18
<211>  23
<212>  PRT
<213>  diphtheria bacilli


<220>
<221>  PEPTIDE
<222>  (1)..(23)
<223>  Diphtheria Th

<400>  18

Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Val Ala Ala Leu Ser 
1               5                   10                  15      


Ile Leu Pro Gly His Gly Cys 
            20              


<210>  19
<211>  21
<212>  PRT
<213>  Plasmodium falciparum


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  Plasmodium falciparum Th

<400>  19

Asp His Glu Lys Lys His Ala Lys Met Glu Lys Ala Ser Ser Val Phe 
1               5                   10                  15      


Asn Val Val Asn Ser 
            20      


<210>  20
<211>  17
<212>  PRT
<213>  Schistosoma mansoni


<220>
<221>  PEPTIDE
<222>  (1)..(17)
<223>  Schistosoma mansoni Th

<400>  20

Lys Trp Phe Lys Thr Asn Ala Pro Asn Gly Val Asp Glu Lys His Arg 
1               5                   10                  15      


His 
    


<210>  21
<211>  25
<212>  PRT
<213>  Cholera Toxin


<220>
<221>  PEPTIDE
<222>  (1)..(25)
<223>  Cholera Toxin Th

<400>  21

Ala Leu Asn Ile Trp Asp Arg Phe Asp Val Phe Cys Thr Leu Gly Ala 
1               5                   10                  15      


Thr Thr Gly Tyr Leu Lys Gly Asn Ser 
            20                  25  


<210>  22
<211>  15
<212>  PRT
<213>  Measles virus


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  MvF 2 Th

<400>  22

Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Gly Ile 
1               5                   10                  15  


<210>  23
<211>  22
<212>  PRT
<213>  Measles virus


<220>
<221>  PEPTIDE
<222>  (1)..(22)
<223>  KKKMvF 3 Th

<220>
<221>  SITE
<222>  (7)..(7)
<223>  S or T

<220>
<221>  SITE
<222>  (10)..(10)
<223>  K or R

<220>
<221>  SITE
<222>  (11)..(11)
<223>  G or T

<220>
<221>  SITE
<222>  (15)..(15)
<223>  H or T

<220>
<221>  SITE
<222>  (16)..(16)
<223>  K or R

<220>
<221>  SITE
<222>  (19)..(19)
<223>  G or T

<400>  23

Lys Lys Lys Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa 
1               5                   10                  15      


Ile Glu Xaa Ile Leu Phe 
            20          


<210>  24
<211>  18
<212>  PRT
<213>  Hepatitis B virus


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  HBsAg 1 Th

<220>
<221>  SITE
<222>  (1)..(1)
<223>  K or R

<220>
<221>  SITE
<222>  (2)..(2)
<223>  K or R

<220>
<221>  SITE
<222>  (3)..(3)
<223>  K or R

<220>
<221>  SITE
<222>  (4)..(4)
<223>  L or I or V or F

<220>
<221>  SITE
<222>  (5)..(5)
<223>  F or K or R

<220>
<221>  SITE
<222>  (6)..(6)
<223>  L or I or V or F

<220>
<221>  SITE
<222>  (7)..(7)
<223>  L or I or V or F

<220>
<221>  SITE
<222>  (9)..(9)
<223>  K or R

<220>
<221>  SITE
<222>  (10)..(10)
<223>  L or I or V or F

<220>
<221>  SITE
<222>  (11)..(11)
<223>  L or I or V or F

<220>
<221>  SITE
<222>  (13)..(13)
<223>  L or I or V or F

<220>
<221>  SITE
<222>  (15)..(15)
<223>  Q or L or I or V or F

<220>
<221>  SITE
<222>  (17)..(17)
<223>  L or I or V or F

<220>
<221>  SITE
<222>  (18)..(18)
<223>  D or R

<400>  24

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Thr Xaa Xaa Xaa Thr Xaa Pro Xaa Ser 
1               5                   10                  15      


Xaa Xaa 
        


<210>  25
<211>  19
<212>  PRT
<213>  Measles virus


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<400>  25

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe 
            


<210>  26
<211>  18
<212>  PRT
<213>  Hepatitis B virus


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  HBsAg 2 Th

<220>
<221>  SITE
<222>  (4)..(4)
<223>  I or F

<220>
<221>  SITE
<222>  (5)..(5)
<223>  I or F

<220>
<221>  SITE
<222>  (6)..(6)
<223>  T or L

<220>
<221>  SITE
<222>  (7)..(7)
<223>  I or L

<220>
<221>  SITE
<222>  (11)..(11)
<223>  I or L

<220>
<221>  SITE
<222>  (14)..(14)
<223>  P or I

<220>
<221>  SITE
<222>  (15)..(15)
<223>  Q or T

<220>
<221>  SITE
<222>  (16)..(16)
<223>  S or T

<220>
<221>  SITE
<222>  (17)..(17)
<223>  L or I

<400>  26

Lys Lys Lys Xaa Xaa Xaa Xaa Thr Arg Ile Xaa Thr Ile Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Asp 
        


<210>  27
<211>  19
<212>  PRT
<213>  Measles virus


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th

<400>  27

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe 
            


<210>  28
<211>  18
<212>  PRT
<213>  Hepatitis B virus


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  HBsAg 3 Th

<400>  28

Lys Lys Lys Ile Ile Thr Ile Thr Arg Ile Ile Thr Ile Ile Thr Thr 
1               5                   10                  15      


Ile Asp 
        


<210>  29
<211>  11
<212>  PRT
<213>  Influenza virus


<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  Influenza Matrix protein 1 _1 Th

<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  Influenza Matrix protein 1_1 Th

<400>  29

Phe Val Phe Thr Leu Thr Val Pro Ser Glu Arg 
1               5                   10      


<210>  30
<211>  15
<212>  PRT
<213>  Influenza virus


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  Influenza Matrix protein 1_2 Th

<400>  30

Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val 
1               5                   10                  15  


<210>  31
<211>  9
<212>  PRT
<213>  Influenza virus


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  Influenza Non-structural protein 1 Th

<400>  31

Asp Arg Leu Arg Arg Asp Gln Lys Ser 
1               5                   


<210>  32
<211>  19
<212>  PRT
<213>  Epstein-Barr virus


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  EBV BHRF1 Th

<400>  32

Ala Gly Leu Thr Leu Ser Leu Leu Val Ile Cys Ser Tyr Leu Phe Ile 
1               5                   10                  15      


Ser Arg Gly 
            


<210>  33
<211>  15
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  Clostridium tetani TT1 Th

<400>  33

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
1               5                   10                  15  


<210>  34
<211>  20
<212>  PRT
<213>  Epstein-Barr virus


<220>
<221>  PEPTIDE
<222>  (1)..(20)
<223>  EBV EBNA-1 Th

<400>  34

Pro Gly Pro Leu Arg Glu Ser Ile Val Cys Tyr Phe Met Val Phe Leu 
1               5                   10                  15      


Gln Thr His Ile 
            20  


<210>  35
<211>  21
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  PEPTIDE
<222>  (1)..(21)
<223>  Clostridium tetani  TT2 Th

<400>  35

Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
1               5                   10                  15      


Ala Ser His Leu Glu 
            20      


<210>  36
<211>  16
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  PEPTIDE
<222>  (1)..(16)
<223>  Clostridium tetani TT3 Th

<400>  36

Lys Phe Ile Ile Lys Arg Tyr Thr Pro Asn Asn Glu Ile Asp Ser Phe 
1               5                   10                  15      


<210>  37
<211>  16
<212>  PRT
<213>  Clostridium tetani


<220>
<221>  PEPTIDE
<222>  (1)..(16)
<223>  Clostridium tetani  TT4 Th

<400>  37

Val Ser Ile Asp Lys Phe Arg Ile Phe Cys Lys Ala Leu Asn Pro Lys 
1               5                   10                  15      


<210>  38
<211>  18
<212>  PRT
<213>  Epstein-Barr virus


<220>
<221>  PEPTIDE
<222>  (1)..(18)
<223>  EBV CP Th

<400>  38

Val Pro Gly Leu Tyr Ser Pro Cys Arg Ala Phe Phe Asn Lys Glu Glu 
1               5                   10                  15      


Leu Leu 
        


<210>  39
<211>  14
<212>  PRT
<213>  Human cytomegalovirus


<220>
<221>  PEPTIDE
<222>  (1)..(14)
<223>  HCMV IE1 Th

<400>  39

Asp Lys Arg Glu Met Trp Met Ala Cys Ile Lys Glu Leu His 
1               5                   10                  


<210>  40
<211>  15
<212>  PRT
<213>  Epstein-Barr virus


<220>
<221>  PEPTIDE
<222>  (1)..(15)
<223>  EBV GP340 Th

<400>  40

Thr Gly His Gly Ala Arg Thr Ser Thr Glu Pro Thr Thr Asp Tyr 
1               5                   10                  15  


<210>  41
<211>  13
<212>  PRT
<213>  Epstein-Barr virus


<220>
<221>  PEPTIDE
<222>  (1)..(13)
<223>  EBV BPLF1 Th

<400>  41

Lys Glu Leu Lys Arg Gln Tyr Glu Lys Lys Leu Arg Gln 
1               5                   10              


<210>  42
<211>  11
<212>  PRT
<213>  Epstein-Barr virus


<220>
<221>  PEPTIDE
<222>  (1)..(11)
<223>  EBV EBNA-2 Th

<400>  42

Thr Val Phe Tyr Asn Ile Pro Pro Met Pro Leu 
1               5                   10      


<210>  43
<211>  71
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(71)
<223>  canine IL-31 97-144

<400>  43

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys 
            20                  25                  30          


Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr 
        35                  40                  45              


Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu 
    50                  55                  60                  


Thr Ile Leu Gln Gln Phe Ser 
65                  70      


<210>  44
<211>  68
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(68)
<223>  canine IL-31 97-144

<400>  44

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu 
            20                  25                  30          


Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser 
        35                  40                  45              


Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu 
    50                  55                  60                  


Gln Gln Phe Ser 
65              


<210>  45
<211>  71
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(71)
<223>  canine IL-31 97-144

<400>  45

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys 
            20                  25                  30          


Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr 
        35                  40                  45              


Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu 
    50                  55                  60                  


Thr Ile Leu Gln Gln Phe Ser 
65                  70      


<210>  46
<211>  68
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(68)
<223>  canine IL-31 97-144

<400>  46

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu 
            20                  25                  30          


Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser 
        35                  40                  45              


Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu 
    50                  55                  60                  


Gln Gln Phe Ser 
65              


<210>  47
<211>  60
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(60)
<223>  canine IL-31 97-133

<400>  47

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys 
            20                  25                  30          


Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr 
        35                  40                  45              


Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys 
    50                  55                  60  


<210>  48
<211>  57
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(57)
<223>  canine IL-31 97-133

<400>  48

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu 
            20                  25                  30          


Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser 
        35                  40                  45              


Val Pro Ala Asp Thr Phe Glu Cys Lys 
    50                  55          


<210>  49
<211>  60
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(60)
<223>  canine IL-31 97-133

<400>  49

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys 
            20                  25                  30          


Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr 
        35                  40                  45              


Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys 
    50                  55                  60  


<210>  50
<211>  57
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(57)
<223>  canine IL-31 97-133

<400>  50

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu 
            20                  25                  30          


Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser 
        35                  40                  45              


Val Pro Ala Asp Thr Phe Glu Cys Lys 
    50                  55          


<210>  51
<211>  49
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(49)
<223>  canine IL-31 97-122

<400>  51

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys 
            20                  25                  30          


Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr 
        35                  40                  45              


Glu 
    


<210>  52
<211>  46
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(46)
<223>  canine IL-31 97-122

<400>  52

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu 
            20                  25                  30          


Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu 
        35                  40                  45      


<210>  53
<211>  49
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(49)
<223>  canine IL-31 97-122

<400>  53

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys 
            20                  25                  30          


Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr 
        35                  40                  45              


Glu 
    


<210>  54
<211>  46
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(46)
<223>  canine IL-31 97-122

<400>  54

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu 
            20                  25                  30          


Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu 
        35                  40                  45      


<210>  55
<211>  41
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(41)
<223>  canine IL-31 97-114

<400>  55

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys 
            20                  25                  30          


Ile Ile Glu Gln Leu Asp Lys Leu Lys 
        35                  40      


<210>  56
<211>  38
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(38)
<223>  canine IL-31 97-114

<400>  56

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu 
            20                  25                  30          


Gln Leu Asp Lys Leu Lys 
        35              


<210>  57
<211>  41
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(41)
<223>  canine IL-31 97-114

<400>  57

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys 
            20                  25                  30          


Ile Ile Glu Gln Leu Asp Lys Leu Lys 
        35                  40      


<210>  58
<211>  38
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(38)
<223>  canine IL-31 97-114

<400>  58

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu 
            20                  25                  30          


Gln Leu Asp Lys Leu Lys 
        35              


<210>  59
<211>  44
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(44)
<223>  canine IL-31 90-110

<400>  59

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser 
            20                  25                  30          


Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu 
        35                  40                  


<210>  60
<211>  41
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(41)
<223>  canine IL-31 90-110

<400>  60

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn 
            20                  25                  30          


Ile Ile Asp Lys Ile Ile Glu Gln Leu 
        35                  40      


<210>  61
<211>  44
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(44)
<223>  canine IL-31 90-110

<400>  61

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser 
            20                  25                  30          


Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu 
        35                  40                  


<210>  62
<211>  41
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(41)
<223>  canine IL-31 90-110

<400>  62

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn 
            20                  25                  30          


Ile Ile Asp Lys Ile Ile Glu Gln Leu 
        35                  40      


<210>  63
<211>  78
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(78)
<223>  canine IL-31 90-144

<400>  63

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser 
            20                  25                  30          


Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys 
        35                  40                  45              


Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe 
    50                  55                  60                  


Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
65                  70                  75              


<210>  64
<211>  75
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(75)
<223>  canine IL-31 90-144

<400>  64

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn 
            20                  25                  30          


Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His 
        35                  40                  45              


Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys 
    50                  55                  60                  


Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
65                  70                  75  


<210>  65
<211>  78
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(78)
<223>  canine IL-31 90-144

<400>  65

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser 
            20                  25                  30          


Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys 
        35                  40                  45              


Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe 
    50                  55                  60                  


Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
65                  70                  75              


<210>  66
<211>  75
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(75)
<223>  canine IL-31 90-144

<400>  66

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn 
            20                  25                  30          


Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His 
        35                  40                  45              


Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys 
    50                  55                  60                  


Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
65                  70                  75  


<210>  67
<211>  78
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(78)
<223>  canine IL-31 90-144

<400>  67

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser 
            20                  25                  30          


Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys 
        35                  40                  45              


Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe 
    50                  55                  60                  


Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
65                  70                  75              


<210>  68
<211>  75
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(75)
<223>  canine IL-31 90-144

<400>  68

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn 
            20                  25                  30          


Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His 
        35                  40                  45              


Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys 
    50                  55                  60                  


Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
65                  70                  75  


<210>  69
<211>  78
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(78)
<223>  canine IL-31 90-144

<400>  69

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser 
            20                  25                  30          


Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys 
        35                  40                  45              


Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe 
    50                  55                  60                  


Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
65                  70                  75              


<210>  70
<211>  75
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(75)
<223>  canine IL-31 90-144

<400>  70

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn 
            20                  25                  30          


Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His 
        35                  40                  45              


Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys 
    50                  55                  60                  


Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
65                  70                  75  


<210>  71
<211>  82
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(82)
<223>  canine IL-31 86-144

<400>  71

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ala Ile Leu Pro Tyr Phe Arg Ala Ile 
            20                  25                  30          


Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu 
        35                  40                  45              


Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro 
    50                  55                  60                  


Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln 
65                  70                  75                  80  


Phe Ser 
        


<210>  72
<211>  79
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(79)
<223>  canine IL-31 86-144

<400>  72

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro Leu 
            20                  25                  30          


Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu 
        35                  40                  45              


Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr 
    50                  55                  60                  


Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
65                  70                  75                  


<210>  73
<211>  82
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(82)
<223>  canine IL-31 86-144

<400>  73

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ala Ile Leu Pro Tyr Phe Arg Ala Ile 
            20                  25                  30          


Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu 
        35                  40                  45              


Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro 
    50                  55                  60                  


Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln 
65                  70                  75                  80  


Phe Ser 
        


<210>  74
<211>  79
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(79)
<223>  canine IL-31 86-144

<400>  74

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro Leu 
            20                  25                  30          


Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu 
        35                  40                  45              


Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr 
    50                  55                  60                  


Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser 
65                  70                  75                  


<210>  75
<211>  76
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(76)
<223>  canine IL-31 97-149, C146 to S146

<400>  75

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys 
            20                  25                  30          


Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr 
        35                  40                  45              


Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu 
    50                  55                  60                  


Thr Ile Leu Gln Gln Phe Ser Ala Ser Leu Glu Ser 
65                  70                  75      


<210>  76
<211>  73
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(73)
<223>  canine IL-31 97-149, C146 to S146

<400>  76

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu 
            20                  25                  30          


Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser 
        35                  40                  45              


Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu 
    50                  55                  60                  


Gln Gln Phe Ser Ala Ser Leu Glu Ser 
65                  70              


<210>  77
<211>  76
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(76)
<223>  canine IL-31 97-149, C146 to S146

<400>  77

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys 
            20                  25                  30          


Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr 
        35                  40                  45              


Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu 
    50                  55                  60                  


Thr Ile Leu Gln Gln Phe Ser Ala Ser Leu Glu Ser 
65                  70                  75      


<210>  78
<211>  73
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(73)
<223>  canine IL-31 97-149, C146 to S146

<400>  78

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu 
            20                  25                  30          


Gln Leu Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser 
        35                  40                  45              


Val Pro Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu 
    50                  55                  60                  


Gln Gln Phe Ser Ala Ser Leu Glu Ser 
65                  70              


<210>  79
<211>  83
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(83)
<223>  canine IL-31 90-149, C146 to S146

<400>  79

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser 
            20                  25                  30          


Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys 
        35                  40                  45              


Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe 
    50                  55                  60                  


Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser Ala Ser 
65                  70                  75                  80  


Leu Glu Ser 
            


<210>  80
<211>  80
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(80)
<223>  canine IL-31 90-149, C146 to S146

<400>  80

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn 
            20                  25                  30          


Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His 
        35                  40                  45              


Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys 
    50                  55                  60                  


Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser Ala Ser Leu Glu Ser 
65                  70                  75                  80  


<210>  81
<211>  83
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(83)
<223>  canine IL-31 90-149, C146 to S146

<400>  81

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser 
            20                  25                  30          


Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys 
        35                  40                  45              


Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe 
    50                  55                  60                  


Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser Ala Ser 
65                  70                  75                  80  


Leu Glu Ser 
            


<210>  82
<211>  80
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(80)
<223>  canine IL-31 90-149, C146 to S146

<400>  82

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp Lys Asn 
            20                  25                  30          


Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Lys Phe Gln His 
        35                  40                  45              


Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr Phe Glu Cys Lys 
    50                  55                  60                  


Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser Ala Ser Leu Glu Ser 
65                  70                  75                  80  


<210>  83
<211>  87
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(87)
<223>  canine IL-31 86-149, C146 to S146

<400>  83

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ala Ile Leu Pro Tyr Phe Arg Ala Ile 
            20                  25                  30          


Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu 
        35                  40                  45              


Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro 
    50                  55                  60                  


Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln 
65                  70                  75                  80  


Phe Ser Ala Ser Leu Glu Ser 
                85          


<210>  84
<211>  84
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(84)
<223>  canine IL-31 86-149, C146 to S146

<400>  84

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro Leu 
            20                  25                  30          


Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu 
        35                  40                  45              


Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr 
    50                  55                  60                  


Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser Ala 
65                  70                  75                  80  


Ser Leu Glu Ser 
                


<210>  85
<211>  87
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(87)
<223>  canine IL-31 86-149, C146 to S146

<400>  85

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ala Ile Leu Pro Tyr Phe Arg Ala Ile 
            20                  25                  30          


Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu 
        35                  40                  45              


Asp Lys Leu Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro 
    50                  55                  60                  


Ala Asp Thr Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln 
65                  70                  75                  80  


Phe Ser Ala Ser Leu Glu Ser 
                85          


<210>  86
<211>  84
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(84)
<223>  canine IL-31 86-149, C146 to S146

<400>  86

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro Leu 
            20                  25                  30          


Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu 
        35                  40                  45              


Lys Phe Gln His Glu Pro Glu Thr Glu Ile Ser Val Pro Ala Asp Thr 
    50                  55                  60                  


Phe Glu Cys Lys Ser Phe Ile Leu Thr Ile Leu Gln Gln Phe Ser Ala 
65                  70                  75                  80  


Ser Leu Glu Ser 
                


<210>  87
<211>  71
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(71)
<223>  human IL-31 98-145

<400>  87

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Leu Asp Asn Lys Ser Val Ile Asp Glu 
            20                  25                  30          


Ile Ile Glu His Leu Asp Lys Leu Ile Phe Gln Asp Ala Pro Glu Thr 
        35                  40                  45              


Asn Ile Ser Val Pro Thr Asp Thr His Glu Cys Lys Arg Phe Ile Leu 
    50                  55                  60                  


Thr Ile Ser Gln Gln Phe Ser 
65                  70      


<210>  88
<211>  68
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(68)
<223>  human IL-31 98-145

<400>  88

Ile Ser Ile Ser Glu Ile Lys Gly Val Ile Val His Lys Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu 
            20                  25                  30          


His Leu Asp Lys Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser 
        35                  40                  45              


Val Pro Thr Asp Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser 
    50                  55                  60                  


Gln Gln Phe Ser 
65              


<210>  89
<211>  71
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(71)
<223>  human IL-31 98-145

<400>  89

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Leu Asp Asn Lys Ser Val Ile Asp Glu 
            20                  25                  30          


Ile Ile Glu His Leu Asp Lys Leu Ile Phe Gln Asp Ala Pro Glu Thr 
        35                  40                  45              


Asn Ile Ser Val Pro Thr Asp Thr His Glu Cys Lys Arg Phe Ile Leu 
    50                  55                  60                  


Thr Ile Ser Gln Gln Phe Ser 
65                  70      


<210>  90
<211>  68
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITh3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K as a spacer

<220>
<221>  PEPTIDE
<222>  (21)..(68)
<223>  human IL-31 98-145

<400>  90

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu 
            20                  25                  30          


His Leu Asp Lys Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser 
        35                  40                  45              


Val Pro Thr Asp Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser 
    50                  55                  60                  


Gln Gln Phe Ser 
65              


<210>  91
<211>  4
<212>  PRT
<213>  synthetic peptide


<220>
<221>  SITE
<222>  (1)..(1)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (1)..(4)
<223>  epsilon-K-KKK as a spacer

<400>  91

Lys Lys Lys Lys 
1               


<210>  92
<211>  6
<212>  PRT
<213>  synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(6)
<223>  Flexible Hinge Spacer

<400>  92

Pro Pro Xaa Pro Xaa Pro 
1               5       


<210>  93
<211>  64
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(64)
<223>  human IL-31 87-150, C147 to S147

<400>  93

Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln Leu Asp Asn Lys Ser 
1               5                   10                  15      


Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys Leu Ile Phe Gln Asp 
            20                  25                  30          


Ala Pro Glu Thr Asn Ile Ser Val Pro Thr Asp Thr His Glu Cys Lys 
        35                  40                  45              


Arg Phe Ile Leu Thr Ile Ser Gln Gln Phe Ser Glu Ser Met Asp Leu 
    50                  55                  60                  


<210>  94
<211>  9
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(9)
<223>  human IL-31 105-113

<400>  94

Asp Glu Ile Ile Glu His Leu Asp Lys 
1               5                   


<210>  95
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  human IL-31 85-115, S85 to C85, I115 to C115

<400>  95

Cys Pro Ala Ile Arg Ala Tyr Leu Lys Thr Ile Arg Gln Leu Asp Asn 
1               5                   10                  15      


Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu Asp Lys Leu Cys 
            20                  25                  30      


<210>  96
<211>  31
<212>  PRT
<213>  Canis lupus


<220>
<221>  PEPTIDE
<222>  (1)..(31)
<223>  canine IL-31 84-114, S84 to C84, K114 to C114

<400>  96

Cys Ser Ala Ile Leu Pro Tyr Phe Arg Ala Ile Arg Pro Leu Ser Asp 
1               5                   10                  15      


Lys Asn Ile Ile Asp Lys Ile Ile Glu Gln Leu Asp Lys Leu Cys 
            20                  25                  30      


<210>  97
<211>  32
<212>  PRT
<213>  Mus musculus


<220>
<221>  1PEPTIDE
<222>  (1)..(32)
<223>  murine IL-31 86-117, S86 to C86

<400>  97

Cys Val Ile Ile Ala His Leu Glu Lys Val Lys Val Leu Ser Glu Asn 
1               5                   10                  15      


Thr Val Asp Thr Ser Trp Val Ile Arg Trp Leu Thr Asn Ile Ser Cys 
            20                  25                  30          


<210>  98
<211>  30
<212>  PRT
<213>  Mus musculus


<220>
<221>  PEPTIDE
<222>  (1)..(30)
<223>  murine IL-31 87-116, V87 to C87,  S116 to C116

<400>  98

Cys Ile Ile Ala His Leu Glu Lys Val Lys Val Leu Ser Glu Asn Thr 
1               5                   10                  15      


Val Asp Thr Ser Trp Val Ile Arg Trp Leu Thr Asn Ile Cys 
            20                  25                  30  


<210>  99
<211>  87
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(87)
<223>  human IL-31 87-150, C147 to S147

<400>  99

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Ala Ile Arg Ala Tyr Leu Lys Thr Ile 
            20                  25                  30          


Arg Gln Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu His Leu 
        35                  40                  45              


Asp Lys Leu Ile Phe Gln Asp Ala Pro Glu Thr Asn Ile Ser Val Pro 
    50                  55                  60                  


Thr Asp Thr His Glu Cys Lys Arg Phe Ile Leu Thr Ile Ser Gln Gln 
65                  70                  75                  80  


Phe Ser Glu Ser Met Asp Leu 
                85          


<210>  100
<211>  32
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(32)
<223>  human IL-31 105-113

<400>  100

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Asp Glu Ile Ile Glu His Leu Asp Lys 
            20                  25                  30          


<210>  101
<211>  54
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(54)
<223>  human IL-31 85-115, S85 to C85, I115 to C115

<400>  101

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Cys Pro Ala Ile Arg Ala Tyr Leu Lys 
            20                  25                  30          


Thr Ile Arg Gln Leu Asp Asn Lys Ser Val Ile Asp Glu Ile Ile Glu 
        35                  40                  45              


His Leu Asp Lys Leu Cys 
    50                  


<210>  102
<211>  54
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF5 Th (UBITh1)

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(54)
<223>  canine IL-31 84-114, S84 to C84, K114 to C114

<400>  102

Ile Ser Ile Thr Glu Ile Lys Gly Val Ile Val His Arg Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Cys Ser Ala Ile Leu Pro Tyr Phe Arg 
            20                  25                  30          


Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu 
        35                  40                  45              


Gln Leu Asp Lys Leu Cys 
    50                  


<210>  103
<211>  54
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(54)
<223>  canine IL-31 84-114, S84 to C84, K114 to C114

<400>  103

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Cys Ser Ala Ile Leu Pro Tyr Phe Arg 
            20                  25                  30          


Ala Ile Arg Pro Leu Ser Asp Lys Asn Ile Ile Asp Lys Ile Ile Glu 
        35                  40                  45              


Gln Leu Asp Lys Leu Cys 
    50                  


<210>  104
<211>  55
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(55)
<223>  murine IL-31 86-117, S86 to C86

<400>  104

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Cys Val Ile Ile Ala His Leu Glu Lys 
            20                  25                  30          


Val Lys Val Leu Ser Glu Asn Thr Val Asp Thr Ser Trp Val Ile Arg 
        35                  40                  45              


Trp Leu Thr Asn Ile Ser Cys 
    50                  55  


<210>  105
<211>  53
<212>  PRT
<213>  Synthetic peptide


<220>
<221>  PEPTIDE
<222>  (1)..(19)
<223>  MvF 4 Th (UBITH3)

<220>
<221>  SITE
<222>  (4)..(4)
<223>  S or T

<220>
<221>  SITE
<222>  (7)..(7)
<223>  K or R

<220>
<221>  SITE
<222>  (8)..(8)
<223>  G or T

<220>
<221>  SITE
<222>  (12)..(12)
<223>  H or T

<220>
<221>  SITE
<222>  (13)..(13)
<223>  K or R

<220>
<221>  SITE
<222>  (20)..(20)
<223>  epsilon-K

<220>
<221>  PEPTIDE
<222>  (20)..(23)
<223>  epsilon K-KKK as a spacer

<220>
<221>  PEPTIDE
<222>  (24)..(53)
<223>  murine IL-31 87-116, V87 to C87,  S116 to C116

<400>  105

Ile Ser Ile Xaa Glu Ile Xaa Xaa Val Ile Val Xaa Xaa Ile Glu Thr 
1               5                   10                  15      


Ile Leu Phe Lys Lys Lys Lys Cys Ile Ile Ala His Leu Glu Lys Val 
            20                  25                  30          


Lys Val Leu Ser Glu Asn Thr Val Asp Thr Ser Trp Val Ile Arg Trp 
        35                  40                  45              


Leu Thr Asn Ile Cys 
    50              


<210>  106
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPRT forward primer

<400>  106
tgacactggc aaaacaatgc a                                                 21


<210>  107
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPRT Reverse Primer

<400>  107
ggtccttttc accagcaagc t                                                 21


<210>  108
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG1 oligonucleotide ODN

<400>  108
tcgtcgtttt gtcgttttgt cgttttgtcg tt                                     32


<210>  109
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG2 oligonucleotide ODN


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  phosphorothioate group

<400>  109
tcgtcgtttt gtcgttttgt cgtt                                              24


<210>  110
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CpG3 Oligonucleotide ODN

<400>  110
tcgtcgtttt gtcgttttgt cgtt                                              24


