                         SEQUENCE LISTING

<110>  UNIVERSITY OF MASSACHUSETTS
 
<120>  Arc Protein Extracellular Vesicle Nucleic Acid Delivery Platform

<130>  UMASS-W-19248

<140>  PCT/US18/65002
<141>  2018-12-11

<150>  US 62/597,145
<151>  2017-12-11

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  1525
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
cacctagata gaataggcga caaaaagaac atcaaatacc aacaggcagc agccaacgtc       60

attgatgacc tcatcgctgc tgccgcccac ccaaacagaa cttttcgtag cctcgccagc      120

cgatcgacgt cagagagagc ccaacaaccg gagagctgga gatggggagc agccacatca      180

acagcagcaa cagcagccac atctcttcat actcttcata ctcactggca atcggcgtgc      240

cggtaagcct cgactagctt ctgaaatcca caaatccacg ctgtttgtat tgctattcgc      300

aatgcctcga aaacggctct attttcatat aatttcacgc cgacttgcgg ctactttggc      360

acagaacgcc agcttttgga aagcaataat ttttattgca acattgaacc tttatttgca      420

actagaaact agatttcgag aatcatcggg cggggcggct gaggatctgg catttcgtcc      480

gtaagatcgg ttattcgcaa tggaggaata tgatattcga accaaatggc gggtgaagtg      540

cctcggcatg gagctccatt ttcttcgaat cttatgtttt gacattgcga gtctgaaatg      600

gatgttgcct gatctccagc cgccccgcac aaccgttgat tctcacaacc gccggctcca      660

ctttgtgccg gtcagcggag aaaaagcgat tatttggcta tcaaaagata tgatcactgt      720

gttgagagac atggcaatca tcgctattgt aaccatatat ttgctgattt ttcgtctgat      780

cctggtcctt tgtgaagcta gcaaaaaacc ccccgcccgg tgaatgccca cttagatcct      840

tttgcaggag gatttcgacg gccctgaagg tgggcgccac ccgtttccgg tagcggcttc      900

ggctgcttcc ggtttccggt gtcgcaaccc ttcgcgatgt cccccgtgcg agtggagcta      960

cagtgggcgt gagccgggca aaacctaaat ttcttcggag atttaaaaaa ccaacaaatt     1020

ttttgacttt tgtcaaaaca attcgaaccc acatagcact acgatggcta acgattcgcc     1080

atccgtgcgg ttggcacgcc aaaactgtct cttcgagatc acgggcctag ggctgtttaa     1140

cattcgaccc aagcgatttc gcgacaggct tcggcacgcc agtatataac ccaaaacaca     1200

caaacgtcag gggctggaac gcgtcactgc cgtgctcctc cagccggcac agtcattccc     1260

cgcccccaca ccaagcaaaa ccggccgctt gtgcagatga cataggcgcg accagccaac     1320

tgacccggct gaccagactt gcaccgtgcg ccatcaactg gaatcttggc cacaagcaca     1380

gcaatagttt ggcccgctat tcccacacag aaacccagag tgggggccta tggaagacca     1440

caagtggttg cgtggaactg ctaaaaatat aaaactgtaa aactaaagac tgaaactaga     1500

aaacaaccat taaactcaga aacgg                                           1525


<210>  2
<211>  767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
cacctagata gaataggcga caaaaagaac atcaaatacc aacaggcagc agccaacgtc       60

attgatgacc tcatcgctgc tgccgcccac ccaaacagaa cttttcgtag cctcgccagc      120

cgatcgacgt cagagagagc ccaacaaccg gagagctgga gatggggagc agccacatca      180

acagcagcaa cagcagccac atctcttcat actcttcata ctcactggca atcggcgtgc      240

cggtaagcct cgactagctt ctgaaatcca caaatccacg ctgtttgtat tgctattcgc      300

aatgcctcga aaacggctct attttcatat aatttcacgc cgacttgcgg ctactttggc      360

acagaacgcc agcttttgga aagcaataat ttttattgca acattgaacc tttatttgca      420

actagaaact agatttcgag aatcatcggg cggggcggct gaggatctgg catttcgtcc      480

gtaagatcgg ttattcgcaa tggaggaata tgatattcga accaaatggc gggtgaagtg      540

cctcggcatg gagctccatt ttcttcgaat cttatgtttt gacattgcga gtctgaaatg      600

gatgttgcct gatctccagc cgccccgcac aaccgttgat tctcacaacc gccggctcca      660

ctttgtgccg gtcagcggag aaaaagcgat tatttggcta tcaaaagata tgatcactgt      720

gttgagagac atggcaatca tcgctattgt aaccatatat ttgctga                    767


<210>  3
<211>  1319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
ttgtggcggt tcctccgcaa ggaggccacc acgtggaagg aagccatcgc tctcatccgc       60

gaacacttct cgcccaccaa gcccgcctac cagatctaca tggacttctt ccaaaacaag      120

caggacgacc atgaccccat tgacaccttc gtcatccaga agcgagcgct gctggcccag      180

ctgcccagcg gtcgccacga cgaggaaacg gaactggatc ttctgttcgg tctgctgaac      240

atcaagtacc gcaagcacat ctcccgccac agtgtccata ccttcaagga tctcctggaa      300

cagggccgca tcatcgagca caacaaccag gaggacgagg aacagcttgc cacagcaaag      360

aacacccgtg gctccaagcg caccacccgc tgcacctact gcagtttccg ggggcacacc      420

ttcgacaact gccgtaagcg ccagaaggat cggcaggagg agcagcacga ggagtaggcg      480

acaaaaagaa catcaaatac caacaggcag cagccaacgt cattgatgac ctcatcgctg      540

ctgccgccca cccaaacaga acttttcgta gcctcgccag ccgatcgacg tcagagagag      600

cccaacaacc ggagagctgg agatggggag cagccacatc aacagcagca acagcagcca      660

catctcttca tactcttcat actcactggc aatcggcgtg ccggtaagcc tcgactagct      720

tctgaaatcc acaaatccac gctgtttgta ttgctattcg caatgcctcg aaaacggctc      780

tattttcata taatttcacg ccgacttgcg gctactttgg cacagaacgc cagcttttgg      840

aaagcaataa tttttattgc aacattgaac ctttatttgc aactagaaac tagatttcga      900

gaatcatcgg gcggggcggc tgaggatctg gcatttcgtc cgtaagatcg gttattcgca      960

atggaggaat atgatattcg aaccaaatgg cgggtgaagt gcctcggcat ggagctccat     1020

tttcttcgaa tcttatgttt tgacattgcg agtctgaaat ggatgttgcc tgatctccag     1080

ccgccccgca caaccgttga ttctcacaac cgccggctcc actttgtgcc ggtcagcgga     1140

gaaaaagcga ttatttggct atcaaaagat atgatcactg tgttgagaga catggcaatc     1200

atcgctattg taaccatata tttgctgatt tttcgtctga tcctggtcct ttgtgaagct     1260

agcaaaaaac cccccgcccg gtgaatgccc acttagatcc ttttgcagga ggatttcga      1319


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
tcagttcaaa tcaccggccg                                                   20


<210>  5
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
gtatgtctcg atgttgccga tg                                                22


<210>  6
<211>  3019
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
caatacatag atacttaatt tggattttaa ttttaataaa aaaaaactaa caaattttct       60

atcgcctgtt agtaattaga ctataagtca ggaatttcgt acgacaatga aaaactataa      120

gttccaagaa aaacactaaa aattcaagaa tgtgagcagc agttctatat tatccaaata      180

gtaagtcagt taataataaa aaataataca ttctattact cgtatacaaa ttataagtaa      240

ccacatatat tgtgaccatt tcacaaaaaa atgtaatagt acaaatcaag gaaaactccc      300

tagaaaccgc atgcaagcct ctacaaaact ttgtttatca gtttgggcca catttacaat      360

caggtttgtc catcagtaca tatagtagtt accggctttc aaactgctat ttttatatag      420

cgcgatgatt cactctgagc aataatacca aaaacataga ccttccctct cttattggct      480

ctccccaatg cctcaagctt tttcgaagtt cgatttcaca acaggcggat ataaaagggc      540

tgcaatgtgg gagagctgtt cagttcaaat caccggccgc attcgctaca ctggctttgt      600

ccgccgactg aaccaagatt aatttgatca cctaacctca cacagcagcg aaaatggccc      660

agcttacaca atggcccagc ttacacagat gaccaacgag cagctccgcg agctgatcga      720

agctgtaaga gcggccgccg tgggcgccgc cggaagtgca gcagcagccg gaggagcaga      780

cgccagcaga ggcaaaggca acttctccgc ttgcacacac agcttcggcg gaacccgcga      840

ccacgacgtg gtcgaggagt tcatcggcaa catcgagaca tacaaggatg tagaaggtat      900

cagcgacgag aacgccctga agggcatctc gctgctgttc tacggtatgg ccagcacctg      960

gtggcaaggc gtccgcaagg aggccaccac gtggaaggaa gccatcgctc tcatccgcga     1020

acacttctcg cccaccaagc ccgcctacca gatctacatg gaattcttcc aaaacaagca     1080

ggacgaccat gaccccattg acaccttcgt catccagaag cgagcgctgc tggcccagct     1140

gcccagcggt cgccacgacg aggaaacgga actggatctt ctgttcggtc tgctgaacat     1200

caagtaccgc aagcacatct cccgccacag tgtccatacc ttcaaggatc tcctggaaca     1260

gggccgcatc atcgagcaca acaaccagga ggacgaggaa cagcttgcca cagcaaagaa     1320

cacccgtggc tccaagcgca ccacccgctg cacctactgc agtttccggg ggcacacctt     1380

cgacaactgc cgtaagcgcc agaaggatcg gcaggaggag cagcacgagg agtaggcgac     1440

aaaaagaaca tcaaatacca acaggcagca gccaacgtca ttgatgacct catcgctgct     1500

gccgcccacc caaacagaac ttttcgtagc ctcgccagcc gatcgacgtc agagagagcc     1560

caacaaccgg agagctggag atggggagca gccacatcaa cagcagcaac agcagccaca     1620

tctcttcata ctcttcatac tcactggcaa tcggcgtgcc ggtaagcctc gactagcttc     1680

tgaaatccac aaatccacgc tgtttgtatt gctattcgca atgcctcgaa aacggctcta     1740

ttttcatata atttcacgcc gacttgcggc tactttggca cagaacgcca gcttttggaa     1800

agcaataatt tttattgcaa cattgaacct ttatttgcaa ctagaaacta gatttcgaga     1860

atcatcgggc ggggcggctg aggatctggc atttcgtccg taagatcggt tattcgcaat     1920

ggaggaatat gatattcgaa ccaaatggcg ggtgaagtgc ctcggcatgg agctccattt     1980

tcttcgaatc ttatgttttg acattgcgag tctgaaatgg atgttgcctg atctccagcc     2040

gccccgcaca accgttgatt ctcacaaccg ccggctccac tttgtgccgg tcagcggaga     2100

aaaagcgatt atttggctat caaaagatat gatcactgtg ttgagagaca tggcaatcat     2160

cgctattgta accatatatt tgctgatttt tcgtctgatc ctggtccttt gtgaagctag     2220

caaaaaaccc cccgcccggt gaatgcccac ttagatcctt ttgcaggagg atttcgacgg     2280

ccctgaaggt gggcgccacc cgtttccggt agcggcttcg gctgcttccg gtttccggtg     2340

tcgcaaccct tcgcgatgtc ccccgtgcga gtggagctac agtgggcgtg agccgggcaa     2400

aacctaaatt tcttcggaga tttaaaaaac caacaaattt tttgactttt gtcaaaacaa     2460

ttcgaaccca catagcacta cgatggctaa cgattcgcca tccgtgcggt tggcacgcca     2520

aaactgtctc ttcgagatca cgggcctagg gctgtttaac attcgaccca agcgatttcg     2580

cgacaggctt cggcacgcca gtatataacc caaaacacac aaacgtcagg ggctggaacg     2640

cgtcactgcc gtgctcctcc agccggcaca gtcattcccc gcccccacac caagcaaaac     2700

cggccgcttg tgcagatgac ataggcgcga ccagccaact gacccggctg accagacttg     2760

caccgtgcgc catcaactgg aatcttggcc acaagcacag caatagtttg gcccgctatt     2820

cccacacaga aacccagagt gggggcctat ggaagaccac aagtggttgc gtggaactgc     2880

taaaaatata aaactgtaaa actaaagact gaaactagaa aacaaccatt aaactcagaa     2940

acggaaaact gcgtaattgt ttttatttta tggggtggat gggacaacat ttttacaggg     3000

aatcattttt ttaaacaaa                                                  3019


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
gatttttcgt ctgatcctgg tc                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
ccgtttctga gtttaatggt tg                                                22


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
tggcccagct tacacagatg                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
gaagttgcct ttgcctctgc                                                   20


<210>  11
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
cacagaacat gaaccttatg ggacgtgtg                                         29


<210>  12
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
tcggtacaag accatacgat ctgc                                              24


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
atgctaagct gtcgcacaaa tg                                                22


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
gttcgatccg taaccgatgt                                                   20


<210>  15
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
gggatcaggc aacccgaatg ag                                                22


<210>  16
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
ctattatcct cttcattata ggatatctga ggcttagtc                              39


<210>  17
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
cgaccacatg aagcagcacg acttctt                                           27


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
cctcggcgcg ggtcttgtag ttg                                               23


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
aagaggaacc gccatccaag                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
ctttagcgca tccttgtcgc                                                   20


