                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       SHARON, Michal
       FUZESI-LEVI, Maria Gabriella
 
<120>  COP9 SIGNALOSOME (CSN) COMPLEX MODULATORS AND USES THEREOF

<130>  75815

<150>  US 62/599,721
<151>  2017-12-17

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal segment of CSNAP

<400>  1

Asp Phe Phe Asn Asp Phe Glu Asp Leu Phe Asp Asp Asp Asp Ile Gln 
1               5                   10                  15      


<210>  2
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Pro Ala Val Asp Glu Met Phe Pro Glu Gly Ala Gly Pro Tyr 
1               5                   10                  15      


Val Asp Leu Asp Glu Ala Gly Gly Ser Thr Gly Leu Leu Met Asp Leu 
            20                  25                  30          


Ala Ala Asn Glu Lys Ala Val His Ala Asp Phe Phe Asn Asp Phe Glu 
        35                  40                  45              


Asp Leu Phe Asp Asp Asp Asp Ile Gln 
    50                  55          


<210>  3
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Examples of peptide penetrating agent

<400>  3

Tyr Gly Arg Lys Lys Arg Arg 
1               5           


<210>  4
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Examples of peptide penetrating agent

<400>  4

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  5
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Examples of peptide penetrating agent

<400>  5

Arg Arg Gln Arg Arg 
1               5   


<210>  6
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  truncated CSNAP

<400>  6

Met Lys Pro Ala Val Asp Glu Met Phe Pro Glu Gly Ala Gly Pro Tyr 
1               5                   10                  15      


Val Asp Leu Asp Glu Ala Gly Gly Ser Thr Gly Leu Leu Met Asp Leu 
            20                  25                  30          


Ala Ala Asn Glu Lys Ala Val His Ala 
        35                  40      


<210>  7
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell penetrating peptide (CPP) sequence

<400>  7

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  8
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell penetrating peptide (CPP) sequence

<400>  8

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro 
1               5                   10          


<210>  9
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell penetrating peptide (CPP) sequence

<400>  9

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro 
1               5                   10      


<210>  10
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell penetrating peptide (CPP) sequence

<400>  10

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10  


<210>  11
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell penetrating peptide (CPP) sequence

<400>  11

Gly Arg Lys Lys Arg Arg Gln Arg Arg 
1               5                   


<210>  12
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell penetrating peptide (CPP) sequence

<400>  12

Gly Arg Lys Lys Arg Arg Gln Arg 
1               5               


<210>  13
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell penetrating peptide (CPP) sequence

<400>  13

Gly Arg Lys Lys Arg Arg Gln 
1               5           


<210>  14
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell penetrating peptide (CPP) sequence

<400>  14

Tyr Gly Arg Lys Lys Arg Arg 
1               5           


<210>  15
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell penetrating peptide (CPP) sequence

<400>  15

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  16
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  cell penetrating peptide (CPP) sequence

<400>  16

Arg Arg Gln Arg Arg 
1               5   


<210>  17
<211>  9
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Examples of oligonucleotide sequences that can be used to form 
       the shRNA loop

<400>  17
uucaagaga                                                                9


<210>  18
<211>  9
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Examples of oligonucleotide sequences that can be used to form 
       the shRNA loop

<400>  18
uuuguguag                                                                9


