                         SEQUENCE LISTING

<110>  UCB Biopharma sprl
 
<120>  Antibodies

<130>  PF0129-WO

<150>  GB1720970.1
<151>  2017-12-15

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  1

Lys Ala Ser Gln Asn Ile Asn Lys Asn Leu Asp 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Tyr Ala Asn Asn Leu Gln Thr 
1               5           


<210>  3
<211>  8
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Tyr Gln Tyr Lys Asn Gly Trp Thr 
1               5               


<210>  4
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Gly Phe Thr Phe Asn Asn Ala Ala Met Tyr 
1               5                   10  


<210>  5
<211>  19
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Ser Tyr Ala Asp Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  6
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Asp Tyr Ser Arg Gly Asp Arg 
1               5           


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR-L3 variant 1

<400>  7

Tyr Gln Tyr Lys Asn Ala Trp Thr 
1               5               


<210>  8
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 
1               5                   10                  15      


Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 
            20                  25                  30          


Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 
        35                  40                  45              


Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 
    50                  55                  60                  


Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 
65                  70                  75                  80  


Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 
                85                  90                  95      


Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 
            100                 105                 110         


Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 
        115                 120                 125             


Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 
    130                 135                 140 


<210>  9
<211>  106
<212>  PRT
<213>  Rattus norvegicus

<400>  9

Asn Ile Gln Met Thr Gln Ser Pro Pro Val Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys His Gly Glu Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Tyr Tyr Ala Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Asn Gly Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  10
<211>  118
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Glu Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Ala 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Ser Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Met 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asp Asn Leu Lys Ser Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Thr Ala Asp Tyr Ser Arg Gly Asp Arg Trp Gly Gln Gly Val 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  11
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat VL nucleotide

<400>  11
aacatccaga tgacccagtc tcctccagtc ctgtctgcat ctgtgggaga cagagtcact       60

ctcagctgca aagcaagtca gaacattaat aagaacttag actggtatca gcaaaagcat      120

ggagaagctc caaaactcct gatgtattat gcaaacaatt tacaaacggg catcccatca      180

aggttcagtg gcagtggatc tggaacagat tacacgctca ccatcagcag cctgcagcct      240

gaagatgttg ccacatatta ctgctatcag tataagaatg ggtggacgtt cggtggaggc      300

accaagctgg aactgaaa                                                    318


<210>  12
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rat VH nucleotide

<400>  12
gaaatgcagc tggtggagtc tggtggagga ttggtgcagc ctaaggagtc attgaaaatc       60

tcatgtgcag cctctggatt caccttcaat aatgctgcca tgtactgggt ccgccaggct      120

ccaggaaagg gtctggaatg ggttgctcgc ataagaacta aacctaataa ttatgcaaca      180

tcttatgctg attcagtgaa aggcagattc accatctcca gagatgattc aaaaagcatg      240

gtctacctac aaatggataa cttgaaaagt gaggacacag ccatgtatta ctgtacagca      300

gattactcca gaggtgacag gtggggccaa ggagtcatgg tcacagtctc gagc            354


<210>  13
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5811 gL5 V-region

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Asn Gly Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  14
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5811 gL5 Light chain

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Asn Gly Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  15
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5811 gL5 V-region nucleotide

<400>  15
gacatccaga tgacccagag cccgagctcc ctgtccgcat cagtggggga tcgcgtgact       60

attacgtgca aagcctcgca gaacatcaac aagaacctcg actggtatca gcagaagcca      120

ggaaaggcgc ctaagctgct gatctactac gccaacaatc tccagaccgg cgtgccctcg      180

cggttctccg gatctgggtc cggtactgat tacaccctga ccattagctc ccttcaaccg      240

gaggacttcg ccacctatta ctgctaccag tacaagaacg gctggacttt tggacaaggc      300

accaaggtcg aaatcaag                                                    318


<210>  16
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5811 gL5 Light chain nucleotide

<400>  16
gacatccaga tgacccagag cccgagctcc ctgtccgcat cagtggggga tcgcgtgact       60

attacgtgca aagcctcgca gaacatcaac aagaacctcg actggtatca gcagaagcca      120

ggaaaggcgc ctaagctgct gatctactac gccaacaatc tccagaccgg cgtgccctcg      180

cggttctccg gatctgggtc cggtactgat tacaccctga ccattagctc ccttcaaccg      240

gaggacttcg ccacctatta ctgctaccag tacaagaacg gctggacttt tggacaaggc      300

accaaggtcg aaatcaagcg tacggtggcc gctccctccg tgttcatctt cccaccctcc      360

gacgagcagc tgaagtccgg caccgcctcc gtcgtgtgcc tgctgaacaa cttctacccc      420

cgcgaggcca aggtgcagtg gaaggtggac aacgccctgc agtccggcaa ctcccaggaa      480

tccgtcaccg agcaggactc caaggacagc acctactccc tgtcctccac cctgaccctg      540

tccaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgaccca ccagggcctg      600

tccagccccg tgaccaagtc cttcaaccgg ggcgagtgc                             639


<210>  17
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5811 gL8 V-region

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Asn Gly Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  18
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5811 gL8 Light chain

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Asn Gly Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  19
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5811 V-region nucleotide

<400>  19
gacatccaga tgacccagag cccgagctcc ctgtccgcat cagtggggga tcgcgtgact       60

attacgtgca aagcctcgca gaacatcaac aagaacctcg actggtatca gcagaagcca      120

ggaaaggcgc ctaagctgct gatctactac gccaacaatc tccagaccgg cgtgccctcg      180

cggttctccg gatctgggtc cggtactgat ttcaccctga ccattagctc ccttcaaccg      240

gaggacttcg ccacctatta ctgctaccag tacaagaacg gctggacttt tggacaaggc      300

accaaggtcg aaatcaag                                                    318


<210>  20
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5811 gL8 Light chain nucleotide

<400>  20
gacatccaga tgacccagag cccgagctcc ctgtccgcat cagtggggga tcgcgtgact       60

attacgtgca aagcctcgca gaacatcaac aagaacctcg actggtatca gcagaagcca      120

ggaaaggcgc ctaagctgct gatctactac gccaacaatc tccagaccgg cgtgccctcg      180

cggttctccg gatctgggtc cggtactgat ttcaccctga ccattagctc ccttcaaccg      240

gaggacttcg ccacctatta ctgctaccag tacaagaacg gctggacttt tggacaaggc      300

accaaggtcg aaatcaagcg tacggtggcc gctccctccg tgttcatctt cccaccctcc      360

gacgagcagc tgaagtccgg caccgcctcc gtcgtgtgcc tgctgaacaa cttctacccc      420

cgcgaggcca aggtgcagtg gaaggtggac aacgccctgc agtccggcaa ctcccaggaa      480

tccgtcaccg agcaggactc caaggacagc acctactccc tgtcctccac cctgaccctg      540

tccaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgaccca ccagggcctg      600

tccagccccg tgaccaagtc cttcaaccgg ggcgagtgc                             639


<210>  21
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5811 gL14 V-region

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Asn Ala Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  22
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5811 gL14 Light chain

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Asn Ala Trp Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  23
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5811 gL14 V-region nucleotide

<400>  23
gacatccaga tgacccagag cccgagctcc ctgtccgcat cagtggggga tcgcgtgact       60

attacgtgca aagcctcgca gaacatcaac aagaacctcg actggtatca gcagaagcca      120

ggaaaggcgc ctaagctgct gatctactac gccaacaatc tccagaccgg cgtgccctcg      180

cggttctccg gatctgggtc cggtactgat ttcaccctga ccattagctc ccttcaaccg      240

gaggacttcg ccacctatta ctgctaccag tacaagaacg cttggacttt tggacaaggc      300

accaaggtcg aaatcaag                                                    318


<210>  24
<211>  639
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5811 gL14 Light chain nucleotide

<400>  24
gacatccaga tgacccagag cccgagctcc ctgtccgcat cagtggggga tcgcgtgact       60

attacgtgca aagcctcgca gaacatcaac aagaacctcg actggtatca gcagaagcca      120

ggaaaggcgc ctaagctgct gatctactac gccaacaatc tccagaccgg cgtgccctcg      180

cggttctccg gatctgggtc cggtactgat ttcaccctga ccattagctc ccttcaaccg      240

gaggacttcg ccacctatta ctgctaccag tacaagaacg cttggacttt tggacaaggc      300

accaaggtcg aaatcaagcg tacggtggcc gctccctccg tgttcatctt cccaccctcc      360

gacgagcagc tgaagtccgg caccgcctcc gtcgtgtgcc tgctgaacaa cttctacccc      420

cgcgaggcca aggtgcagtg gaaggtggac aacgccctgc agtccggcaa ctcccaggaa      480

tccgtcaccg agcaggactc caaggacagc acctactccc tgtcctccac cctgaccctg      540

tccaaggccg actacgagaa gcacaaggtg tacgcctgcg aagtgaccca ccagggcctg      600

tccagccccg tgaccaagtc cttcaaccgg ggcgagtgc                             639


<210>  25
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5811 gH4 V-region

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Ala 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Ser Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ala Asp Tyr Ser Arg Gly Asp Arg Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  26
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5811 gH4 Heavy chain

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Ala 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Ser Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ala Asp Tyr Ser Arg Gly Asp Arg Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  27
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5811 gH4 V-region nucleotide

<400>  27
gaagtgcagc ttgtggagag cggaggtgga ctcgtgaagc ctggcggatc tctgcgcctg       60

tcctgcgccg cctcggggtt cacctttaac aatgccgcaa tgtattgggt cagacaggcc      120

ccgggaaagg gtttggaatg ggtggctagg attcggacta agcccaacaa ctacgcgacc      180

tcctacgccg atagcgtgaa gggcagattc accatctccc gggacgactc aaagaacacg      240

ctgtacctcc aaatgaactc cctgaaaacc gaggacaccg ccgtgtacta ctgcaccgcg      300

gactactccc ggggcgatcg ctggggacag gggactatgg tcactgtctc gagt            354


<210>  28
<211>  1335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5811 gH4 Heavy chain nucleotide

<400>  28
gaagtgcagc ttgtggagag cggaggtgga ctcgtgaagc ctggcggatc tctgcgcctg       60

tcctgcgccg cctcggggtt cacctttaac aatgccgcaa tgtattgggt cagacaggcc      120

ccgggaaagg gtttggaatg ggtggctagg attcggacta agcccaacaa ctacgcgacc      180

tcctacgccg atagcgtgaa gggcagattc accatctccc gggacgactc aaagaacacg      240

ctgtacctcc aaatgaactc cctgaaaacc gaggacaccg ccgtgtacta ctgcaccgcg      300

gactactccc ggggcgatcg ctggggacag gggactatgg tcactgtctc gagtgcctcc      360

accaagggcc cctccgtgtt ccctctggcc ccttgctccc ggtccacctc cgagtctacc      420

gccgctctgg gctgcctggt caaggactac ttccccgagc ccgtgacagt gtcctggaac      480

tctggcgccc tgacctccgg cgtgcacacc ttccctgccg tgctgcagtc ctccggcctg      540

tactccctgt cctccgtcgt gaccgtgccc tcctccagcc tgggcaccaa gacctacacc      600

tgtaacgtgg accacaagcc ctccaacacc aaggtggaca agcgggtgga atctaagtac      660

ggccctccct gccccccctg ccctgcccct gaatttctgg gcggaccttc cgtgttcctg      720

ttccccccaa agcccaagga caccctgatg atctcccgga cccccgaagt gacctgcgtg      780

gtggtggacg tgtcccagga agatcccgag gtccagttca attggtacgt ggacggcgtg      840

gaagtgcaca atgccaagac caagcccaga gaggaacagt tcaactccac ctaccgggtg      900

gtgtccgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaagagta caagtgcaag      960

gtgtccaaca agggcctgcc ctccagcatc gaaaagacca tctccaaggc caagggccag     1020

ccccgcgagc cccaggtgta caccctgccc cctagccagg aagagatgac caagaaccag     1080

gtgtccctga cctgtctggt caagggcttc tacccctccg acattgccgt ggaatgggag     1140

tccaacggcc agcccgagaa caactacaag accacccccc ctgtgctgga cagcgacggc     1200

tccttcttcc tgtactctcg gctgaccgtg gacaagtccc ggtggcagga aggcaacgtc     1260

ttctcctgct ccgtgatgca cgaggccctg cacaaccact acacccagaa gtccctgtcc     1320

ctgagcctgg gcaag                                                      1335


<210>  29
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  30
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Asp Ala Phe Asp Val Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  31
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  31
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta ccccttggac gttcggccaa      300

gggaccaagg tggaaatcaa a                                                321


<210>  32
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  32
gaggtgcagc tggtggagtc tgggggaggc ttggtaaagc ctggggggtc ccttagactc       60

tcctgtgcag cctctggatt cactttcagt aacgcctgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggttggccgt attaaaagca aaactgatgg tgggacaaca      180

gactacgctg cacccgtgaa aggcagattc accatctcaa gagatgattc aaaaaacacg      240

ctgtatctgc aaatgaacag cctgaaaacc gaggacacag ccgtgtatta ctgtaccaca      300

gatgcttttg atgtctgggg ccaagggaca atggtcaccg tctcttca                   348


<210>  33
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rabbit Fc human 68-140 a-syn

<400>  33

Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys Thr Val Glu 
1               5                   10                  15      


Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys Lys Asp Gln 
            20                  25                  30          


Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile Leu Glu Asp 
        35                  40                  45              


Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu Glu 
    50                  55                  60                  


Gly Tyr Gln Asp Tyr Glu Pro Glu Ala Val Glu Lys Thr Val Ala Pro 
65                  70                  75                  80  


Ser Thr Cys Ser Lys Pro Thr Cys Pro Pro Pro Glu Leu Leu Gly Gly 
                85                  90                  95      


Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            100                 105                 110         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Asp 
        115                 120                 125             


Asp Pro Glu Val Gln Phe Thr Trp Tyr Ile Asn Asn Glu Gln Val Arg 
    130                 135                 140                 


Thr Ala Arg Pro Pro Leu Arg Glu Gln Gln Phe Asn Ser Thr Ile Arg 
145                 150                 155                 160 


Val Val Ser Thr Leu Pro Ile Ala His Gln Asp Trp Leu Arg Gly Lys 
                165                 170                 175     


Glu Phe Lys Cys Lys Val His Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            180                 185                 190         


Lys Thr Ile Ser Lys Ala Arg Gly Gln Pro Leu Glu Pro Lys Val Tyr 
        195                 200                 205             


Thr Met Gly Pro Pro Arg Glu Glu Leu Ser Ser Arg Ser Val Ser Leu 
    210                 215                 220                 


Thr Cys Met Ile Asn Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp 
225                 230                 235                 240 


Glu Lys Asn Gly Lys Ala Glu Asp Asn Tyr Lys Thr Thr Pro Ala Val 
                245                 250                 255     


Leu Asp Ser Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Pro 
            260                 265                 270         


Thr Ser Glu Trp Gln Arg Gly Asp Val Phe Thr Cys Ser Val Met His 
        275                 280                 285             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Ile Ser Arg Ser Pro 
    290                 295                 300                 


Gly Lys 
305     


<210>  34
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5811 rat-mouse chimeric light chain

<400>  34

Asn Ile Gln Met Thr Gln Ser Pro Pro Val Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn 
            20                  25                  30          


Leu Asp Trp Tyr Gln Gln Lys His Gly Glu Ala Pro Lys Leu Leu Met 
        35                  40                  45              


Tyr Tyr Ala Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Asn Gly Trp Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Thr Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  35
<211>  442
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5811 rat-mouse chimeric heavy chain

<400>  35

Glu Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Ala 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Ser Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Met 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asp Asn Leu Lys Ser Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Thr Ala Asp Tyr Ser Arg Gly Asp Arg Trp Gly Gln Gly Val 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
            180                 185                 190         


Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro 
    210                 215                 220                 


Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro 
225                 230                 235                 240 


Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 
                245                 250                 255     


Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 
            260                 265                 270         


Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu 
        275                 280                 285             


Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met 
    290                 295                 300                 


His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser 
305                 310                 315                 320 


Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                325                 330                 335     


Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln 
            340                 345                 350         


Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe 
        355                 360                 365             


Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu 
    370                 375                 380                 


Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe 
385                 390                 395                 400 


Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn 
                405                 410                 415     


Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr 
            420                 425                 430         


Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
        435                 440         


<210>  36
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  5811 rat-mouse chimeric Fab-His heavy chain

<400>  36

Glu Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Ala 
            20                  25                  30          


Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Ser Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Met 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asp Asn Leu Lys Ser Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Thr Ala Asp Tyr Ser Arg Gly Asp Arg Trp Gly Gln Gly Val 
            100                 105                 110         


Met Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
        115                 120                 125             


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
145                 150                 155                 160 


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
            180                 185                 190         


Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys His His His His 
    210                 215                 220                 


His His His His His His 
225                 230 


