﻿                         序列表

<110>  华南理工大学

<120>  一种化合物皮肤致敏体外评估细胞模型及其构建方法

<160>  11

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  23
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  sgRNA-1


<400>  1
ttaacaggtg ggcgtgcatc agg                                                23

<210>  2
<211>  23
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  sgRNA-10


<400>  2
ggtccttaca ctcagctttc tgg                                                23

<210>  3
<211>  23
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  sgRNA-13


<400>  3
gctttatgcc atgtgaatgc agg                                                23

<210>  4
<211>  8388
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  同源重组载体的序列


<400>  4
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg        60
ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg       120
cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc       180
ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt       240
gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata       300
tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc       360
cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc       420
attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt       480
atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt       540
atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca       600
tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg       660
actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc       720
aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg       780
gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca       840
ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc       900
gtttaaacgg gccctctaga ctcgagcggc cgccatcacc atgcttagca aacgtgtgag       960
tttgagagga agatttacag ctcagaccta attgctggca aagtttaagg agaggacagg      1020
gagcaggcag aagtctgaaa accacgcctg ggcccaagaa tgttttcaca atgtggcctg      1080
gctgcacagg gaagaacaga cagcttgaag aagtagtgag ctgcccgtct ttgaaggtat      1140
tcaagcagtg gctagaggga cacctgtctg tggtcttgca gaatcctggc gttgggcagt      1200
gactgtacca cagaccctga ggccgctctg ctttgctttc ctatgacatc agacaccctg      1260
atgcacgccc acctgttaat gaccttgccc cattttctct ttcagattct gcccccgtgg      1320
agactcccag agggaagccc ccactcaaca cccgctccca ggctccgctt ctccgatggg      1380
tccttacact cagctttctg gtggcgacag ttgctgtagg gctttatgcc atggagggca      1440
gaggaagtct tctaacatgc ggtgacgtgg aggagaatcc cggccctatg gaagatgcca      1500
aaaacattaa gaagggccca gcgccattct acccactcga agacgggacc gccggcgagc      1560
agctgcacaa agccatgaag cgctacgccc tggtgcccgg caccatcgcc tttaccgacg      1620
cacatatcga ggtggacatt acctacgccg agtacttcga gatgagcgtt cggctggcag      1680
aagctatgaa gcgctatggg ctgaatacaa accatcggat cgtggtgtgc agcgagaata      1740
gcttgcagtt cttcatgccc gtgttgggtg ccctgttcat cggtgtggct gtggccccag      1800
ctaacgacat ctacaacgag cgcgagctgc tgaacagcat gggcatcagc cagcccaccg      1860
tcgtattcgt gagcaagaaa gggctgcaaa agatcctcaa cgtgcaaaag aagctaccga      1920
tcatacaaaa gatcatcatc atggatagca agaccgacta ccagggcttc caaagcatgt      1980
acaccttcgt gacttcccat ttgccacccg gcttcaacga gtacgacttc gtgcccgaga      2040
gcttcgaccg ggacaaaacc atcgccctga tcatgaacag tagtggcagt accggattgc      2100
ccaagggcgt agccctaccg caccgcaccg cttgtgtccg attcagtcat gcccgcgacc      2160
ccatcttcgg caaccagatc atccccgaca ccgctatcct cagcgtggtg ccatttcacc      2220
acggcttcgg catgttcacc acgctgggct acttgatctg cggctttcgg gtcgtgctca      2280
tgtaccgctt cgaggaggag ctattcttgc gcagcttgca agactataag attcaatctg      2340
ccctgctggt gcccacacta tttagcttct tcgctaagag cactctcatc gacaagtacg      2400
acctaagcaa cttgcacgag atcgccagcg gcggggcgcc gctcagcaag gaggtaggtg      2460
aggccgtggc caaacgcttc cacctaccag gcatccgcca gggctacggc ctgacagaaa      2520
caaccagcgc cattctgatc acccccgaag gggacgacaa gcctggcgca gtaggcaagg      2580
tggtgccctt cttcgaggct aaggtggtgg acttggacac cggtaagaca ctgggtgtga      2640
accagcgcgg cgagctgtgc gtccgtggcc ccatgatcat gagcggctac gttaacaacc      2700
ccgaggctac aaacgctctc atcgacaagg acggctggct gcacagcggc gacatcgcct      2760
actgggacga ggacgagcac ttcttcatcg tggaccggct gaagagcctg atcaaataca      2820
agggctacca ggtagcccca gccgaactgg agagcatcct gctgcaacac cccaacatct      2880
tcgacgccgg ggtcgccggc ctgcccgacg acgatgccgg cgagctgccc gccgcagtcg      2940
tcgtgctgga acacggtaaa accatgaccg agaaggagat cgtggactat gtggccagcc      3000
aggttacaac cgccaagaag ctgcgcggtg gtgttgtgtt cgtggacgag gtgcctaaag      3060
gactgaccgg caagttggac gcccgcaaga tccgcgagat tctcattaag gccaagaagg      3120
gcggcaagat cgccgtgtga atgcaggcat gctggctccc agggccatga actttgtccg      3180
gtggaaggcc ttctttctag agagggaatt ctcttggctg gcttccttac cgtgggcact      3240
gaaggctttc agggcctcca gccctctcac tgtgtccctc tctctggaaa ggaggaagga      3300
gcctatggca tcttccccaa cgaaaagcac atccaggcaa tggcctaaac ttcagagggg      3360
gcgaagggat cagccctgcc cttcagcatc ctcagttcct gcagcagagc ctggaagaca      3420
ccctaatgtg gcagctgtct caaacctcca aaagccctga gtttcaagta tccttgttga      3480
cacggccatg accactttcc ccgtgggcca tggcaatttt tacacaaacc tgaaaagatg      3540
ttgtgtcttg tgtttttgtc ttatttttgt tggagccact ctgttcctgg ctcagcctca      3600
aatgcagtat ttttgttgtg ttctgttgtt tttatagcag ggttggggtg gtttttgagc      3660
catgcgtggg tggggaggga ggtgtttaac ggcactgtgg ccttggtcta acttttgtgt      3720
gaaataataa acaacattgt ctgatagtag cttgaagtag ttttcatggg ctttgttatt      3780
cttggggaac tgaccttttc ctccctggtt tcttgcgtgc tcggtaggag aagtggtgat      3840
agggggttgg caggagctgg tctgtttgag aatacagaag gtgagctttt cttttctttt      3900
tttttttttt tgagatggag tctcactctg tcacccagga tccgagctcg gtaccaagct      3960
taagtttaaa ccgctgatca gcctcgactg tgccttctag ttgccagcca tctgttgttt      4020
gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat      4080
aaaatgagga aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg      4140
tggggcagga cagcaagggg gaggattggg aagacaatag caggcatgct ggggatgcgg      4200
tgggctctat ggcttctgag gcggaaagaa ccagctgggg ctctaggggg tatccccacg      4260
cgccctgtag cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta      4320
cacttgccag cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt      4380
tcgccggctt tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg      4440
ctttacggca cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat      4500
cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac      4560
tcttgttcca aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag      4620
ggattttgcc gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg      4680
cgaattaatt ctgtggaatg tgtgtcagtt agggtgtgga aagtccccag gctccccagc      4740
aggcagaagt atgcaaagca tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc      4800
aggctcccca gcaggcagaa gtatgcaaag catgcatctc aattagtcag caaccatagt      4860
cccgccccta actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc      4920
ccatggctga ctaatttttt ttatttatgc agaggccgag gccgcctctg cctctgagct      4980
attccagaag tagtgaggag gcttttttgg aggcctaggc ttttgcaaaa agctcccggg      5040
agcttgtata tccattttcg gatctgatca agagacagga tgaggatcgt ttcgcatgat      5100
tgaacaagat ggattgcacg caggttctcc ggccgcttgg gtggagaggc tattcggcta      5160
tgactgggca caacagacaa tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca      5220
ggggcgcccg gttctttttg tcaagaccga cctgtccggt gccctgaatg aactgcagga      5280
cgaggcagcg cggctatcgt ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga      5340
cgttgtcact gaagcgggaa gggactggct gctattgggc gaagtgccgg ggcaggatct      5400
cctgtcatct caccttgctc ctgccgagaa agtatccatc atggctgatg caatgcggcg      5460
gctgcatacg cttgatccgg ctacctgccc attcgaccac caagcgaaac atcgcatcga      5520
gcgagcacgt actcggatgg aagccggtct tgtcgatcag gatgatctgg acgaagagca      5580
tcaggggctc gcgccagccg aactgttcgc caggctcaag gcgcgcatgc ccgacggcga      5640
ggatctcgtc gtgacccatg gcgatgcctg cttgccgaat atcatggtgg aaaatggccg      5700
cttttctgga ttcatcgact gtggccggct gggtgtggcg gaccgctatc aggacatagc      5760
gttggctacc cgtgatattg ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt      5820
gctttacggt atcgccgctc ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga      5880
gttcttctga gcgggactct ggggttcgaa atgaccgacc aagcgacgcc caacctgcca      5940
tcacgagatt tcgattccac cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc      6000
cgggacgccg gctggatgat cctccagcgc ggggatctca tgctggagtt cttcgcccac      6060
cccaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc      6120
acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta      6180
tcttatcatg tctgtatacc gtcgacctct agctagagct tggcgtaatc atggtcatag      6240
ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc      6300
ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc      6360
tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa      6420
cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg      6480
ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg      6540
ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag      6600
gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac      6660
gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga      6720
taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt      6780
accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc      6840
tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc      6900
cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta      6960
agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat      7020
gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca      7080
gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct      7140
tgatccggca aacaaaccac cgctggtagc ggtttttttg tttgcaagca gcagattacg      7200
cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag      7260
tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc      7320
tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact      7380
tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt      7440
cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta      7500
ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta      7560
tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc      7620
gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat      7680
agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt      7740
atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg      7800
tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca      7860
gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta      7920
agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg      7980
cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact      8040
ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg      8100
ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt      8160
actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga      8220
ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc      8280
atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa      8340
caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtc                   8388

<210>  5
<211>  19
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  sp6


<400>  5
gatttaggtg acactatag                                                     19

<210>  6
<211>  21
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  HMOX1-sgRNA-JD-F


<400>  6
tgttttcaca atgtggcctg g                                                  21

<210>  7
<211>  20
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  HMOX1-sgRNA-JD-R


<400>  7
ccattgcctg gatgtgcttt                                                    20

<210>  8
<211>  20
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  HMOX1-LR-F


<400>  8
aaccagggat gggactgaac                                                    20

<210>  9
<211>  20
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  HMOX1-LR-R


<400>  9
tcgcccacca gctacttaaa                                                    20

<210>  10
<211>  20
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  HMOX1-HRL-F


<400>  10
caggtggcac atctacccag                                                    20

<210>  11
<211>  20
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  HMOX1-HRL-R


<400>  11
gcaagctatt ctcgctgcac                                                    20

