                         SEQUENCE LISTING

<110>  Zymergen Inc.
 
<120>  ENGINEERED BIOSYNTHETIC PATHWAYS FOR PRODUCTION OF 
       (6E)-8-HYDROXYGERANIOL BY FERMENTATION

<130>  ZMGNP007PUS/ZYM0027-WO-00

<140>  Not Assigned
<141>  2018-12-06

<150>  US 62/596,013
<151>  2017-12-07

<160>  112   

<170>  PatentIn version 3.5

<210>  1
<211>  591
<212>  PRT
<213>  Vitis vinifera (Grape)

<400>  1

Met Ser Arg Phe Val Thr Met Pro Ser His Val Leu Pro Ser Ser Phe 
1               5                   10                  15      


Val Ala Pro Ser Leu Gln Val Ser Ser Ser Pro Cys Ser Trp Arg Thr 
            20                  25                  30          


Arg Pro Ser Pro Cys Thr Ser Cys His Leu Ser Pro Ser Ser Ser Ser 
        35                  40                  45              


Lys Pro Leu Leu Gly Ser His Asp Tyr Ser Leu Leu Lys Ser Leu Thr 
    50                  55                  60                  


Leu Ser Pro His Ala Val Asn Ser Glu Ala Asp Ser Ser Thr Arg Arg 
65                  70                  75                  80  


Met Lys Glu Val Lys Glu Arg Thr Trp Glu Ala Phe Tyr Arg Ala Trp 
                85                  90                  95      


Asp Ser Arg Ala Ala Met Glu Met Val Asp Thr Val Glu Arg Leu Gly 
            100                 105                 110         


Leu Ser Tyr His Phe Glu Asp Glu Ile Asn Ala Leu Leu Gln Arg Phe 
        115                 120                 125             


Cys Asp Trp Asn Ala Ser Glu Asp Leu Phe Thr Thr Ala Leu Arg Phe 
    130                 135                 140                 


Arg Leu Leu Arg Gln Asn Gly Phe Pro Thr His Ser Asp Val Phe Gly 
145                 150                 155                 160 


Lys Phe Met Asp Lys Asn Gly Lys Phe Lys Glu Ser Leu Thr Glu Asp 
                165                 170                 175     


Ile Trp Gly Met Leu Ser Leu His Glu Ala Ser His Leu Gly Ala Lys 
            180                 185                 190         


Asn Glu Glu Val Leu Ala Glu Ala Lys Glu Phe Thr Arg Ile His Leu 
        195                 200                 205             


Ile Gln Ser Met Pro His Met Glu Pro His Phe Ser Ser His Val Gly 
    210                 215                 220                 


Arg Ala Leu Glu Leu Pro Arg His Leu Arg Met Val Arg Leu Glu Ala 
225                 230                 235                 240 


Arg Asn Tyr Ile Gly Glu Tyr Ser Arg Glu Ser Asn Pro Asn Leu Ala 
                245                 250                 255     


Phe Leu Glu Leu Ala Lys Leu Asp Phe Asp Met Val Gln Ser Leu His 
            260                 265                 270         


Gln Lys Glu Leu Ala Glu Ile Val Arg Trp Trp Lys Gln Leu Gly Leu 
        275                 280                 285             


Val Asp Lys Leu Asp Phe Ala Arg Asp Arg Pro Met Glu Cys Phe Leu 
    290                 295                 300                 


Trp Thr Val Gly Ile Phe Pro Asp Pro Arg His Ser Ser Cys Arg Ile 
305                 310                 315                 320 


Glu Leu Thr Lys Ala Ile Ala Ile Leu Leu Val Ile Asp Asp Ile Tyr 
                325                 330                 335     


Asp Ser Tyr Gly Ser Leu Asp Glu Leu Ala Leu Phe Thr Asp Ala Val 
            340                 345                 350         


Lys Arg Trp Asp Leu Gly Ala Met Asp Gln Leu Pro Glu Tyr Met Lys 
        355                 360                 365             


Ile Cys Tyr Met Ala Leu Tyr Asn Thr Thr Asn Asp Ile Ala Tyr Arg 
    370                 375                 380                 


Ile Leu Lys Glu His Gly Trp Ser Val Ile Glu Asp Leu Lys Arg Thr 
385                 390                 395                 400 


Trp Met Asp Ile Phe Gly Ala Phe Leu Ala Glu Ala Tyr Cys Phe Lys 
                405                 410                 415     


Gly Gly His Val Pro Ser Leu Glu Glu Tyr Leu Thr Asn Ala Val Thr 
            420                 425                 430         


Thr Gly Gly Thr Tyr Met Ala Leu Val His Ala Phe Phe Leu Met Gly 
        435                 440                 445             


Gln Gly Val Thr Arg Glu Asn Met Ala Met Leu Lys Pro Tyr Pro Asn 
    450                 455                 460                 


Ile Phe Ser Cys Ser Gly Lys Ile Leu Arg Leu Trp Asp Asp Leu Gly 
465                 470                 475                 480 


Thr Ala Arg Glu Glu Gln Glu Arg Gly Asp Asn Ala Ser Ser Ile Glu 
                485                 490                 495     


Cys Tyr Lys Arg Glu Arg Glu Met Asp Thr Val Leu Glu Asp Glu Ala 
            500                 505                 510         


Cys Arg Lys His Ile Arg Gln Met Ile Gln Ser Leu Trp Val Glu Leu 
        515                 520                 525             


Asn Gly Glu Leu Val Ala Ser Ser Ala Leu Pro Leu Ser Ile Ile Lys 
    530                 535                 540                 


Ala Ala Phe Asn Leu Ser Arg Thr Ala Gln Val Ile Tyr Gln His Gly 
545                 550                 555                 560 


Asp Asp Asn Lys Thr Ser Ser Val Glu Asp His Val Gln Ala Leu Leu 
                565                 570                 575     


Phe Arg Pro Val Ser Ser Asn Gly His Ala Gln Ile Thr Met His 
            580                 585                 590     


<210>  2
<211>  1773
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  2
atgtcgcgtt ttgtcaccat gccctctcac gtcctgcctt catcatttgt cgccccatcc       60

cttcaagttt ccagctcgcc ctgcagctgg cgtacccgac cgtcgccctg caccagctgc      120

cacctttcgc catcgtcgag ctctaaaccg ttgttgggta gccacgatta cagcctgttg      180

aagagcctga ccctttcgcc acacgcggtg aattccgaag cagactcttc gactcgccgt      240

atgaaagaag tgaaagaacg aacctgggag gcattctacc gcgcttggga ttcgcgcgca      300

gcaatggaaa tggtagatac tgttgaacga ctgggacttt cttaccactt cgaagacgaa      360

atcaacgcac tcctccaacg cttttgtgac tggaacgcta gcgaggattt gttcacaact      420

gcgctgcgct ttcgcctgct tcgccaaaac ggtttcccga cccacagcga cgtcttcggc      480

aaatttatgg ataaaaatgg caaattcaaa gaatcactga ccgaagacat ttggggtatg      540

ttgtcccttc acgaggcgtc tcaccttggt gctaaaaacg aagaagtcct tgcggaggct      600

aaagaattta ctcgcatcca tctgattcag tcgatgccac acatggagcc tcatttttcg      660

tcgcacgtgg gccgagctct ggagctgccg cgccacctgc gtatggtccg tttggaagca      720

cgtaactata tcggcgagta ttcgcgcgag tccaatccaa accttgcatt cctggagttg      780

gccaagttgg atttcgatat ggtgcagtct ttgcaccaga aagaattggc cgaaatcgtg      840

cgctggtgga aacagctggg cctcgtggac aagttggatt tcgcacgtga ccgcccaatg      900

gaatgtttcc tctggaccgt tggcatcttt ccggatcccc gacactcctc gtgccgcatc      960

gaacttacca aagctattgc aattctgttg gtgatcgacg acatctatga ttcctacggc     1020

tcgctggatg aactcgctct ctttaccgat gccgtcaagc gctgggatct gggagccatg     1080

gatcaactcc cagaatacat gaagatttgt tacatggcgc tgtacaacac caccaatgat     1140

atcgcttatc gcatcctcaa agagcatggt tggtccgtca tcgaggactt gaaacgaacg     1200

tggatggata tctttggcgc attccttgct gaggcatatt gcttcaaagg aggccatgtg     1260

ccttcgcttg aggaatattt gaccaacgca gttacgactg gcggtaccta tatggcactg     1320

gtgcacgcct tctttcttat gggacagggc gtgacccgcg agaatatggc aatgctgaag     1380

ccctatccta atatctttag ctgctcagga aagatcctcc gtctttggga tgatcttggc     1440

acagcgcgtg aggagcagga gcgtggcgac aacgccagct ccatcgaatg ctacaagcgt     1500

gaacgtgaga tggacaccgt cctcgaagat gaggcatgcc gcaaacacat ccgtcaaatg     1560

attcagtcct tgtgggttga attgaatggc gagcttgtgg cttcatctgc attgccgctg     1620

tccatcatca aggcagcgtt caatctctcc cgcaccgcac aagtgattta tcagcacggt     1680

gacgataaca aaacgtcctc tgttgaggat catgttcaag ccttgctttt ccgtcctgtt     1740

tcctccaatg gtcacgcaca aattaccatg cac                                  1773


<210>  3
<211>  292
<212>  PRT
<213>  Vitis vinifera (Grape)

<400>  3

Met Glu Cys Phe Leu Trp Thr Val Gly Ile Phe Pro Asp Pro Arg His 
1               5                   10                  15      


Ser Ser Cys Arg Ile Glu Leu Thr Lys Ala Ile Ala Ile Leu Leu Val 
            20                  25                  30          


Ile Asp Asp Ile Tyr Asp Ser Tyr Gly Ser Leu Asp Glu Leu Ala Leu 
        35                  40                  45              


Phe Thr Asp Ala Val Lys Arg Trp Asp Leu Gly Ala Met Asp Gln Leu 
    50                  55                  60                  


Pro Glu Tyr Met Lys Ile Cys Tyr Met Ala Leu Tyr Asn Thr Thr Asn 
65                  70                  75                  80  


Asp Ile Ala Tyr Arg Ile Leu Lys Glu His Gly Trp Ser Val Ile Glu 
                85                  90                  95      


Asp Leu Lys Arg Thr Trp Met Asp Ile Phe Gly Ala Phe Leu Ala Glu 
            100                 105                 110         


Ala Tyr Cys Phe Lys Gly Gly His Val Pro Ser Leu Glu Glu Tyr Leu 
        115                 120                 125             


Thr Asn Ala Val Thr Thr Gly Gly Thr Tyr Met Ala Leu Val His Ala 
    130                 135                 140                 


Phe Phe Leu Met Gly Gln Gly Val Thr Arg Glu Asn Met Ala Met Leu 
145                 150                 155                 160 


Lys Pro Tyr Pro Asn Ile Phe Ser Cys Ser Gly Lys Ile Leu Arg Leu 
                165                 170                 175     


Trp Asp Asp Leu Gly Thr Ala Arg Glu Glu Gln Glu Arg Gly Asp Asn 
            180                 185                 190         


Ala Ser Ser Ile Glu Cys Tyr Lys Arg Glu Arg Glu Met Asp Thr Val 
        195                 200                 205             


Leu Glu Asp Glu Ala Cys Arg Lys His Ile Arg Gln Met Ile Gln Ser 
    210                 215                 220                 


Leu Trp Val Glu Leu Asn Gly Glu Leu Val Ala Ser Ser Ala Leu Pro 
225                 230                 235                 240 


Leu Ser Ile Ile Lys Ala Ala Phe Asn Leu Ser Arg Thr Ala Gln Val 
                245                 250                 255     


Ile Tyr Gln His Gly Asp Asp Asn Lys Thr Ser Ser Val Glu Asp His 
            260                 265                 270         


Val Gln Ala Leu Leu Phe Arg Pro Val Ser Ser Asn Gly His Ala Gln 
        275                 280                 285             


Ile Thr Met His 
    290         


<210>  4
<211>  876
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  4
atggaatgtt ttctgtggac cgttggtatt ttcccagacc cgcgacactc ttcctgtcgt       60

atcgaactta cgaaagcgat tgcaatcctt ttggtgattg atgatatcta cgactcgtac      120

ggctcattgg acgaacttgc gctcttcacc gatgcagtaa aacgctggga tttgggcgcc      180

atggatcaat tgccggaata catgaagatc tgctatatgg cattgtacaa caccacgaac      240

gacatcgcat atcgtatcct caaagagcac ggttggtctg taatcgaaga cctcaagcgc      300

acctggatgg atatcttcgg agcgttcctc gcagaagcgt attgcttcaa gggtggacac      360

gttccttccc tcgaagaata cctgacaaac gcggttacta ccggaggtac atacatggct      420

ctcgtgcatg ctttctttct tatgggtcag ggtgttaccc gcgaaaacat ggcgatgctt      480

aaaccgtatc caaacatctt ctcgtgttca ggcaagatcc tgcgcttgtg ggatgatttg      540

ggaacagctc gcgaagagca ggagcgtggt gataacgcaa gctctatcga atgttacaaa      600

cgtgaacgcg aaatggacac agtcctggag gatgaagcct gccgcaagca cattcgccag      660

atgatccaat ccctctgggt tgaactgaac ggcgaactcg ttgcaagctc cgcgctgccg      720

ctttcgatca ttaaggcggc cttcaatctc tcgcgcactg cacaggttat ttaccagcat      780

ggcgatgaca ataaaacgtc ctccgtagaa gatcatgtgc aggctctgtt gtttcgccca      840

gtgagcagca acggacacgc acagatcacg atgcac                                876


<210>  5
<211>  603
<212>  PRT
<213>  Perilla setoyensis

<400>  5

Met Cys Ser Ile Ser Gln Lys Val Val Ile Gly Leu Asn Lys Ala Ala 
1               5                   10                  15      


Ala Asn Asn Cys Leu Gln Asn Leu Asp Arg Arg Gly Phe Lys Thr Arg 
            20                  25                  30          


Arg Val Ser Ser Ser Glu Ala Ala Ser Cys Leu Arg Ala Ser Ser Ser 
        35                  40                  45              


Leu Gln Leu Asp Val Lys Pro Val Glu Glu Gly Arg Arg Ser Gly Asn 
    50                  55                  60                  


Tyr Gln Pro Ser Ile Trp Asp Phe Asn Tyr Val Gln Ser Leu Asn Thr 
65                  70                  75                  80  


Pro Tyr Lys Glu Glu Arg Tyr Leu Thr Arg His Ala Glu Leu Ile Val 
                85                  90                  95      


Gln Val Lys Pro Leu Leu Glu Lys Lys Met Glu Ala Thr Gln Gln Leu 
            100                 105                 110         


Glu Leu Ile Asp Asp Leu Asn Asn Leu Gly Leu Ser Tyr Phe Phe Gln 
        115                 120                 125             


Asp Arg Ile Lys Gln Ile Leu Ser Phe Ile Tyr Asp Glu Asn Gln Cys 
    130                 135                 140                 


Phe His Ser Asn Ile Asn Asp Gln Ala Glu Lys Arg Asp Leu Tyr Phe 
145                 150                 155                 160 


Thr Ala Leu Gly Phe Arg Leu Leu Arg Gln His Gly Phe Asn Val Ser 
                165                 170                 175     


Gln Glu Val Phe Asp Cys Phe Lys Asn Asp Lys Gly Ser Asp Phe Lys 
            180                 185                 190         


Ala Ser Leu Ser Gly Asn Thr Lys Gly Leu Leu Gln Leu Tyr Glu Ala 
        195                 200                 205             


Ser Phe Leu Val Arg Glu Gly Glu Asp Thr Leu Glu Leu Ala Arg Gln 
    210                 215                 220                 


Phe Ala Thr Lys Phe Leu Arg Arg Lys Leu Asp Glu Ile Asp Asp Asn 
225                 230                 235                 240 


His Leu Leu Ser Arg Ile His His Ser Leu Glu Ile Pro Leu His Trp 
                245                 250                 255     


Arg Ile Gln Arg Leu Glu Ala Arg Trp Phe Leu Asp Ala Tyr Ala Thr 
            260                 265                 270         


Arg His Asp Met Asn Pro Ile Ile Leu Glu Leu Ala Lys Leu Asp Phe 
        275                 280                 285             


Asn Ile Ile Gln Ala Thr His Gln Glu Glu Leu Lys Asp Val Ser Arg 
    290                 295                 300                 


Trp Trp Gln Asn Thr Arg Leu Ala Glu Lys Leu Pro Phe Val Arg Asp 
305                 310                 315                 320 


Arg Leu Val Glu Ser Tyr Phe Trp Ala Ile Ala Leu Phe Glu Pro His 
                325                 330                 335     


Gln Tyr Gly Tyr Gln Arg Arg Val Ala Ala Lys Ile Ile Thr Leu Ala 
            340                 345                 350         


Thr Ser Ile Asp Asp Val Tyr Asp Ile Tyr Gly Thr Leu Asp Glu Leu 
        355                 360                 365             


Gln Leu Phe Thr Asp Asn Phe Arg Arg Trp Asp Thr Glu Ser Leu Gly 
    370                 375                 380                 


Gly Leu Pro Tyr Ser Met Gln Leu Phe Tyr Met Val Ile His Asn Phe 
385                 390                 395                 400 


Val Ser Glu Leu Ala Tyr Glu Ile Leu Lys Glu Lys Gly Phe Ile Ala 
                405                 410                 415     


Ile Pro Tyr Leu Gln Arg Ser Trp Val Asp Leu Ala Glu Ser Phe Leu 
            420                 425                 430         


Lys Glu Ala Asn Trp Tyr Tyr Ser Gly Tyr Thr Pro Ser Leu Glu Glu 
        435                 440                 445             


Tyr Ile Asp Asn Gly Ser Ile Ser Ile Gly Ala Val Ala Val Leu Ser 
    450                 455                 460                 


Gln Val Tyr Phe Thr Leu Ala Asn Ser Ile Glu Lys Pro Lys Ile Glu 
465                 470                 475                 480 


Ser Met Tyr Lys Tyr His His Ile Leu Arg Leu Ser Gly Leu Leu Val 
                485                 490                 495     


Arg Leu His Asp Asp Leu Gly Thr Ser Leu Phe Glu Lys Lys Arg Gly 
            500                 505                 510         


Asp Val Pro Lys Ala Val Glu Ile Cys Met Lys Glu Arg Asn Asp Thr 
        515                 520                 525             


Glu Glu Glu Ala Glu Glu His Val Lys Tyr Leu Ile Arg Glu Ala Trp 
    530                 535                 540                 


Lys Glu Met Asn Thr Ala Thr Ala Ala Ala Gly Cys Pro Phe Met Asp 
545                 550                 555                 560 


Glu Leu Asn Val Ala Ala Ala Asn Leu Gly Arg Ala Ala Gln Phe Val 
                565                 570                 575     


Tyr Leu Asp Gly Asp Gly His Gly Val Gln His Ser Lys Ile His Gln 
            580                 585                 590         


Gln Met Gly Gly Leu Met Phe Lys Pro Tyr Val 
        595                 600             


<210>  6
<211>  1809
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  6
atgtgcagca tctctcaaaa ggtcgttatt ggattgaata aggcagcggc caataactgc       60

ctccaaaacc ttgatcgccg aggttttaaa acacgccgtg tttcatcctc cgaagcggct      120

tcttgcctcc gagcctcaag ctcgctgcag cttgatgtca agccggtgga ggaaggccga      180

cgttccggta actatcagcc atcaatctgg gattttaatt atgtccagtc cctcaacacc      240

ccctacaaag aggaacgtta ccttacccga cacgcggaac tcatcgttca ggtcaagccg      300

cttctcgaaa aaaagatgga ggctactcag cagttggagc tcatcgatga ccttaacaac      360

ctcggtctga gctacttttt ccaagaccgc atcaagcaga ttctctcatt catctatgat      420

gaaaatcagt gtttccactc caatatcaat gatcaagctg aaaagcgaga cctgtacttt      480

accgcccttg gatttcgtct ccttcgccag cacggcttta acgtgtctca ggaggtgttc      540

gattgcttca aaaacgataa aggctccgat tttaaagcgt ccctgtctgg aaacaccaag      600

ggcctcctcc agctctacga agcctccttc ttggtccgtg agggtgaaga caccctcgaa      660

ctggcccgtc agttcgcgac caagttcctg cgccgcaagc ttgacgaaat cgacgacaac      720

catctgctct cacgaattca ccactcactc gaaatcccgt tgcactggcg catccagcgt      780

ctggaggcgc gctggtttct ggacgcgtac gctacacgcc acgatatgaa tcccattatc      840

ttggagctcg caaaactgga ctttaatatt attcaagcaa cccaccaaga agagctcaag      900

gacgtgagcc gttggtggca gaatacgcgc ctggccgaaa agctcccgtt tgtgcgcgat      960

cgacttgtcg agtcatactt ttgggccatc gcactctttg agccacatca atatggatac     1020

cagcgccgtg ttgctgccaa gattatcacc ctcgcgacat ccatcgatga cgtgtacgac     1080

atctacggca ctctcgacga gctccaactt tttaccgata acttccgtcg ctgggacacg     1140

gaatccttgg gcggtcttcc ttactcgatg cagttgttct acatggtgat tcacaacttt     1200

gtctctgagt tggcctatga aatcctgaaa gaaaaaggtt ttatcgccat cccctacctc     1260

caacgctcct gggttgattt ggcagaatcc tttttgaaag aggcaaactg gtactactct     1320

ggttatacac cctccctcga agaatacatc gacaacggct ccatctcaat tggcgcagta     1380

gctgtgttgt cccaagttta tttcactttg gcaaattcta tcgaaaagcc aaagattgaa     1440

tctatgtaca agtaccacca tattttgcgt ctgtcgggtt tgttggtgcg cctgcacgat     1500

gacttgggaa cttccttgtt cgagaagaag cgcggcgatg ttcctaaggc ggtcgaaatt     1560

tgcatgaaag aacgcaacga tacggaggag gaagcagaag aacacgttaa gtacttgatt     1620

cgcgaagcct ggaaggagat gaacactgct acggcagctg caggatgtcc ttttatggat     1680

gagctcaacg tggctgctgc caatctgggt cgcgcagccc agttcgtgta cctcgacgga     1740

gacggtcatg gcgtgcagca ctccaaaatc catcaacaga tgggtggcct tatgtttaaa     1800

ccgtatgtg                                                             1809


<210>  7
<211>  495
<212>  PRT
<213>  Swertia mussotii (Felwort)

<400>  7

Met Asp Phe Asp Phe Leu Thr Ile Ala Ile Gly Phe Leu Phe Thr Ile 
1               5                   10                  15      


Thr Leu Tyr Gln Ala Leu Asn Phe Phe Ser Arg Lys Ser Lys Asn Leu 
            20                  25                  30          


Pro Pro Gly Pro Ser Pro Leu Pro Leu Ile Gly Asn Leu His Leu Leu 
        35                  40                  45              


Gly Asp Gln Pro His Lys Ser Leu Ala Lys Leu Ala Lys Lys His Gly 
    50                  55                  60                  


Pro Ile Met Gly Leu Gln Leu Gly Gln Val Thr Thr Ile Val Val Thr 
65                  70                  75                  80  


Ser Ser Gly Met Ala Lys Glu Val Leu Gln Lys Gln Asp Leu Ala Phe 
                85                  90                  95      


Ser Ser Arg Ser Ile Pro Asn Ala Ile His Ala His Asp Gln Tyr Lys 
            100                 105                 110         


Tyr Ser Val Ile Trp Leu Pro Val Ala Ser Arg Trp Arg Gly Leu Arg 
        115                 120                 125             


Lys Ala Leu Asn Ser Asn Met Phe Ser Gly Asn Arg Leu Asp Ala Asn 
    130                 135                 140                 


Gln His Leu Arg Ser Arg Lys Val Gln Glu Leu Ile Ala Tyr Cys Arg 
145                 150                 155                 160 


Lys Ser Ser Gln Thr Gly Asp Ala Ile Asp Val Gly Arg Ala Ala Phe 
                165                 170                 175     


Arg Thr Ser Leu Asn Leu Leu Ser Asn Thr Met Phe Ser Lys Asp Leu 
            180                 185                 190         


Thr Asp Pro Tyr Ser Asp Ser Ala Lys Glu Phe Lys Asp Leu Val Trp 
        195                 200                 205             


Asn Val Met Val Glu Ala Gly Lys Pro Asn Leu Val Asp Tyr Phe Pro 
    210                 215                 220                 


Leu Leu Asp Lys Val Asp Pro Gln Gly Ile Arg Lys Arg Met Thr Ile 
225                 230                 235                 240 


His Phe Gly Lys Ile Leu Glu Leu Phe Gly Gly Leu Ile Asp Glu Arg 
                245                 250                 255     


Leu Gln Gln Lys Lys Ala Lys Gly Val Asn Asp Asp Val Leu Asp Val 
            260                 265                 270         


Leu Leu Thr Thr Ser Glu Glu Ser Pro Glu Glu Ile Asp Arg Thr His 
        275                 280                 285             


Ile Gln Arg Met Cys Leu Asp Leu Phe Val Ala Gly Thr Asp Thr Thr 
    290                 295                 300                 


Ser Ser Thr Leu Glu Trp Ala Met Ser Glu Met Leu Lys Asn Pro Glu 
305                 310                 315                 320 


Lys Met Lys Ala Ala Gln Ala Glu Leu Ala Gln Val Ile Gly Lys Gly 
                325                 330                 335     


Lys Ala Val Glu Glu Ala Asp Leu Ala Arg Leu Pro Tyr Leu Arg Cys 
            340                 345                 350         


Ala Ile Lys Glu Thr Leu Arg Ile His Pro Pro Val Pro Leu Leu Ile 
        355                 360                 365             


Pro Arg Arg Thr Glu Gln Glu Val Glu Val Cys Gly Tyr Thr Val Pro 
    370                 375                 380                 


Lys Asn Ser Gln Val Leu Val Asn Val Trp Ala Ile Ser Arg Asp Asp 
385                 390                 395                 400 


Ala Ile Trp Lys Asp Pro Leu Ser Phe Lys Pro Glu Arg Phe Leu Glu 
                405                 410                 415     


Ser Glu Leu Glu Met Arg Gly Lys Asp Phe Glu Leu Ile Pro Phe Gly 
            420                 425                 430         


Ala Gly Arg Arg Ile Cys Pro Gly Leu Pro Leu Ala Val Arg Met Val 
        435                 440                 445             


Pro Val Met Leu Gly Ser Leu Leu Asn Ser Phe Asp Trp Lys Leu Glu 
    450                 455                 460                 


Gly Gly Ile Ala Pro Lys Asp Leu Asp Met Glu Glu Lys Phe Gly Ile 
465                 470                 475                 480 


Thr Leu Gln Lys Ala His Pro Leu Arg Ala Val Ala Thr Pro Leu 
                485                 490                 495 


<210>  8
<211>  1486
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  8
atggatttcg acttccttac tatcgcgatt ggttttctgt ttactatcac tttgtaccaa       60

gcgcttaact tcttttcccg taaatcaaag aatctcccac caggtccgtc cccattgcca      120

ctcattggta acttgcatct gctcggtgac caaccccata agtcactggc caaactcgca      180

aagaaacatg gtcctatcat gggactgcaa ctgggtcaag tcaccaccat cgttgtaacg      240

tcttctggta tggcgaagga ggttctccag aagcaggacc tggccttttc aagccgttcc      300

atcccaaacg caatccacgc ccatgaccaa tataagtata gcgtgatttg gctcccggtg      360

gcgtcccgat ggcgaggtct gcgtaaggcg ctcaactcca atatgttctc tggaaatcgc      420

ctggatgcaa atcagcactt gcgttcacga aaggtccagg aactgatcgc ctattgccgc      480

aagtcatctc aaactggcga tgctattgat gttggtcgcg cagcattccg cacttcattg      540

aacctgctta gcaacaccat gttcagcaag gaccttacag acccttattc tgactccgca      600

aaagaattta aggatctcgt ttggaacgtg atggtggagg caggcaaacc caatttggtt      660

gactacttcc ctctgttgga taaagttgac ccccaaggca ttcgaaagcg catgaccatt      720

catttcggta aaatcctcga attgtttggc ggacttatcg acgaacgatt gcagcaaaaa      780

aaagcaaagg gagtgaacga cgacgtgctg gacgtgctcc ttaccacttc agaggaaagc      840

ccggaggaaa tcgaccgtac ccatatccag cgcatgtgcc tggacttgtt cgtcgcgggc      900

acggacacta cgtcgtcgac gctcgaatgg gccatgtctg aaatgcttaa gaaccccgaa      960

aaaatgaagg cggcccaggc agaactggcc caggttattg gaaaaggcaa ggctgttgaa     1020

gaagcagact tggcgcgcct gccatacctg cgctgcgcta ttaaagagac ccttcgaatc     1080

catcctccgg ttccactgct gattcctcga cgcacggaac aagaggtcga ggtgtgcggt     1140

tatacggttc cgaagaactc acaggttttg gtgaacgttt gggccatctc tcgagacgat     1200

gcaatttgga aggatccact ctcctttaag cctgaacgtt ttctggagtc tgaattggag     1260

atgcgtggta aggatttcga gcttatccca ttcggtgcgg gccgacgcat ttgcccgggc     1320

cttcctctgg cggtgcgcat ggtcccagtg atgcttggat ctcttttgaa ctcattcgat     1380

tggaagctgg agggcggcat cgcgcctaag gacttggaca tggaagaaaa gttcggcatc     1440

acgctgcaga aagcccaccc tctccgcgct gtcgccactc cactgt                    1486


<210>  9
<211>  505
<212>  PRT
<213>  Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)

<400>  9

Met Asn Phe Phe Ile Ser Val Leu Leu Tyr Phe Leu Leu Thr Phe Ala 
1               5                   10                  15      


Val Ile Gln Ser Leu Asp Tyr Ile Leu Arg Arg Ser Lys Arg Lys Ser 
            20                  25                  30          


Gly Lys Leu Pro Pro Gly Pro Ser Arg Leu Pro Ile Val Gly Asn Leu 
        35                  40                  45              


Leu Asp Leu Gly Asp Lys Pro His Lys Ser Leu Ala Lys Leu Ala Lys 
    50                  55                  60                  


Thr His Gly Gln Leu Met Ser Leu Lys Leu Gly Gln Val Thr Thr Ile 
65                  70                  75                  80  


Val Val Ser Ser Ala Thr Met Ala Lys Glu Val Leu Gln Lys His Asp 
                85                  90                  95      


Leu Thr Phe Cys Asn Arg Thr Val Val Asp Ala Val Arg Ala Leu Asp 
            100                 105                 110         


His His Glu Ala Gly Ile Ala Trp Leu Pro Val Ala Thr Arg Trp Arg 
        115                 120                 125             


Asn Leu Arg Lys Ile Cys Asn Ser His Ile Phe Thr Ser Gln Lys Leu 
    130                 135                 140                 


Asp Ala Asn Gln Asp Leu Arg Arg Lys Lys Val Gln Asp Leu Leu Ala 
145                 150                 155                 160 


Glu Val Gln Glu Arg Cys Leu Val Gly Glu Ala Val Asp Leu Arg Gln 
                165                 170                 175     


Ala Ala Phe Thr Ala Thr Leu Asn Ala Leu Ser Asn Thr Val Leu Ser 
            180                 185                 190         


Leu Asp Leu Thr Asp Leu Ser Ser Asp Ile Ala Arg Glu Phe Lys Glu 
        195                 200                 205             


His Ile Ser Cys Ile Met Asp Glu Ala Gly Lys Pro Asn Leu Val Asp 
    210                 215                 220                 


Tyr Phe Pro Leu Leu Arg Arg Ile Asp Pro Gln Gly Ile Arg Arg Arg 
225                 230                 235                 240 


Thr Ala Ile His Phe Gly Lys Val Phe Asp Leu Phe Asp Arg Leu Ile 
                245                 250                 255     


Ile Glu Arg Leu Gln Leu Arg Lys Val Lys Gly Tyr Ile Pro Leu Asp 
            260                 265                 270         


Asp Met Leu Asp Thr Leu Leu Thr Ile Ser Glu Val Asn Asn Glu Glu 
        275                 280                 285             


Met Asp Ala Thr Arg Ile Lys His Phe Phe Leu Asp Leu Phe Gly Ala 
    290                 295                 300                 


Gly Thr Asp Thr Thr Ser Ser Thr Leu Glu Trp Ala Met Ala Glu Leu 
305                 310                 315                 320 


Leu His Ser Pro Lys Thr Leu Leu Lys Ala Arg Ala Glu Leu Glu Arg 
                325                 330                 335     


Thr Ile Gly Glu Gly Asn Leu Leu Glu Glu Ser Asp Ile Thr Arg Leu 
            340                 345                 350         


Pro Tyr Leu Gln Ala Val Ile Lys Glu Thr Leu Arg Leu His Pro Ala 
        355                 360                 365             


Val Pro Phe Leu Leu Pro His Lys Ala Gly Ala Asp Ala Glu Ile Gly 
    370                 375                 380                 


Gly Phe Thr Val Pro Lys Asn Ala Gln Val Leu Val Asn Val Trp Ala 
385                 390                 395                 400 


Ile Gly Arg Asp Pro Ser Met Trp Glu Asp Pro Asn Ser Phe Val Pro 
                405                 410                 415     


Glu Arg Phe Leu Glu Ser Gly Ile Asp His Arg Gly Gln Asn Phe Glu 
            420                 425                 430         


Phe Ile Pro Phe Gly Ser Gly Arg Arg Ile Cys Pro Gly Leu Pro Leu 
        435                 440                 445             


Ala Met Arg Met Leu Pro Leu Met Leu Gly Ser Leu Ile Leu Ser Phe 
    450                 455                 460                 


Asp Trp Lys Leu Ala Asp Gly Val Thr Pro Glu Asn Leu Asn Met Asp 
465                 470                 475                 480 


Asp Lys Phe Gly Leu Thr Leu Leu Lys Ala Gln Pro Leu Arg Ala Ile 
                485                 490                 495     


Pro Ile Thr Arg Glu Leu Lys His Gly 
            500                 505 


<210>  10
<211>  1515
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  10
atgaactttt tcatctctgt gctgttgtat ttccttctga cattcgcggt gattcaatcc       60

ctggactaca tccttcgccg ctccaagcgt aagtccggca aactgccgcc aggcccttca      120

cgacttccga ttgttggaaa cctgctggac ctgggagaca agccccacaa atccctcgca      180

aagctggcga aaacccacgg ccaattgatg tcacttaagc tcggacaagt gaccacgatc      240

gtggtttcaa gcgctaccat ggccaaggag gtgttgcaga agcatgatct gactttctgt      300

aaccgcactg ttgttgacgc tgttcgcgcg ctggaccacc atgaggccgg cattgcgtgg      360

ctgccagtgg ctacccgttg gcgcaacctg cgtaaaattt gcaatagcca tatctttaca      420

tcccagaaac tcgacgctaa tcaagacctg cgacgcaaaa aagtccagga tctgctggca      480

gaagtgcaag agcgctgcct ggtaggtgag gctgttgact tgcgtcaagc agcatttacc      540

gcgactctta atgccctgag caacactgtt ttgtcgctcg acctcaccga tctgtcatca      600

gatatcgctc gcgagtttaa agagcacatc tcctgcatta tggatgaagc gggcaagcca      660

aacctggttg attactttcc tttgcttcgc cgcatcgacc cgcagggcat tcgtcgccgc      720

actgcaattc acttcggcaa ggtgttcgat ctcttcgatc gcttgattat cgaacgtttg      780

cagctccgca aagtcaaggg ttacattccc ctggacgaca tgctggacac tttgctcacg      840

atctcagaag tcaacaacga agagatggac gctacacgta tcaagcactt ttttttggat      900

ttgttcggcg caggcaccga tacgacttca tcgactcttg agtgggccat ggcagagctc      960

ttgcactcgc cgaaaaccct cctcaaagcc cgcgctgaac tggaacgcac catcggcgag     1020

ggcaatcttt tggaggaatc cgacatcacc cgtctcccct acctgcaggc tgtcatcaag     1080

gagactctcc gactccatcc agccgtgccc ttcctccttc cacacaaggc aggcgctgat     1140

gctgaaatcg gcggttttac tgtgccaaaa aacgcgcagg tcttggtgaa tgtctgggcg     1200

attggccgtg atccctcaat gtgggaagac cccaattcct tcgtccctga acgcttcttg     1260

gaatcaggta tcgatcaccg aggacaaaac tttgaattta tccctttcgg cagcggacgt     1320

cgaatttgcc caggtcttcc gctggcgatg cgtatgctcc ctctcatgct cggttctctc     1380

atcttgtcct tcgactggaa gttggcagat ggtgtgacgc cagaaaactt gaacatggac     1440

gataagttcg gtttgactct cctgaaagct cagccccttc gtgcgatccc catcacccga     1500

gaattgaaac acggt                                                      1515


<210>  11
<211>  501
<212>  PRT
<213>  Phaseolus angularis (Azuki bean) (Vigna angularis)

<400>  11

Met Glu Thr Asn Ser Thr Leu Phe Phe Thr Phe Thr Val Leu Leu Ile 
1               5                   10                  15      


Thr Ile Ile Thr Phe Leu Lys Ala Leu Lys Ser Leu Phe Thr Pro Asn 
            20                  25                  30          


Lys Ser Lys Ser Asn Leu Pro Pro Gly Pro Lys Gly Leu Pro Leu Val 
        35                  40                  45              


Gly Asn Leu Leu Gln Leu Gly Ala Lys Pro His Gln Thr Leu Ala Thr 
    50                  55                  60                  


Leu Ala Asn Ile His Gly Ser Ile Met Ser Leu Lys Leu Gly Gln Glu 
65                  70                  75                  80  


Thr Thr Ile Val Met Ser Ser Ala Glu Ala Ala Lys Gly Val Leu Gln 
                85                  90                  95      


Ile His Asp His Phe Leu Ser Asn Arg Lys Ile Pro Asp Ala Met Arg 
            100                 105                 110         


Gly Ser Ser His Asp His Phe Ser Leu Pro Phe Met Pro Val Ser Gln 
        115                 120                 125             


Gln Trp Arg Glu Leu Arg Lys Leu Cys Asn Glu Leu Leu Phe Ser Asn 
    130                 135                 140                 


Lys Asn Leu Asp Ala Thr Gln Gly Leu Arg Ser Lys Lys Val Arg Glu 
145                 150                 155                 160 


Leu Tyr Ser Asp Ile His Arg Ser Ser Leu Lys Gly Glu Pro Val Asn 
                165                 170                 175     


Ile Gly Arg Leu Ala Phe Lys Thr Thr Ile Asn Gln Leu Ser Asn Thr 
            180                 185                 190         


Ile Tyr Ser Glu Asp Phe Leu Gln Ser Ala Glu Lys Ala Gly Glu Met 
        195                 200                 205             


Lys Glu Leu Val Thr Asn Ile Met Lys Glu Val Gly Arg Pro Asn Leu 
    210                 215                 220                 


Ala Asp Cys Phe Pro Val Leu Lys Met Ile Asp Pro His Gly Ile Arg 
225                 230                 235                 240 


Arg Arg Thr Gly Ser Tyr Phe Ser Lys Leu Leu Asn Ile Phe Lys Ser 
                245                 250                 255     


Leu Ile His Lys Arg Leu Glu Leu Arg Lys Asp Ala Ala Gly Tyr Cys 
            260                 265                 270         


Thr Lys Lys Asp Met Leu Asp Ala Met Leu Asn Asp Ala Gln His Lys 
        275                 280                 285             


Met Asp Ile Val Lys Ile Gln Arg Leu Ser Leu Asp Leu Phe Val Ala 
    290                 295                 300                 


Gly Thr Asp Thr Val Thr Ser Thr Val Glu Trp Ala Met Ala Glu Leu 
305                 310                 315                 320 


Leu His Asn Pro His Val Met Ser Lys Ala Lys Glu Glu Leu Glu Arg 
                325                 330                 335     


Ile Ile Gly Lys Asp Asn Leu Val Glu Glu Ser Asp Ile Ala Lys Leu 
            340                 345                 350         


Pro Tyr Leu Gln Ala Ile Val Lys Glu Thr Phe Arg Leu His Pro Ala 
        355                 360                 365             


Val Pro Leu Leu Leu Pro Arg Lys Ala Glu Val Glu Phe Glu Met His 
    370                 375                 380                 


Gly Tyr Thr Ile Pro Lys Gly Ala Gln Val Leu Ile Asn Val Trp Ala 
385                 390                 395                 400 


Ile Gly Arg Asp Pro Asn Leu Trp Glu Lys Pro Arg Leu Phe Trp Pro 
                405                 410                 415     


Glu Arg Phe Leu Glu Ser Glu Ile Asp Phe Lys Gly Arg Ser Phe Glu 
            420                 425                 430         


Leu Thr Pro Phe Gly Gly Gly Arg Arg Ile Cys Pro Gly Leu Pro Leu 
        435                 440                 445             


Ala Ile Arg Leu Val Phe Leu Met Leu Gly Leu Phe Ile Asn Ser Phe 
    450                 455                 460                 


Asp Trp Glu Leu Gln Asp Ile Gln Pro Glu Asp Met Asn Met Asp Glu 
465                 470                 475                 480 


Asn Phe Gly Leu Thr Leu Glu Lys Ala Gln Pro Val Leu Ala Ile Pro 
                485                 490                 495     


Ile Ile Pro Lys His 
            500     


<210>  12
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  12
atggagacta actctaccct tttctttaca ttcaccgtcc tcctgatcac aatcattacg       60

ttcctgaagg cgttgaaatc tttgtttacc cctaacaagt caaaatctaa cctcccaccc      120

ggtcccaagg gccttccttt ggttggcaac ctgcttcagt tgggcgcgaa gccgcaccag      180

accctcgcaa ccctcgcaaa catccacgga tccatcatgt ccctcaaatt gggtcaagag      240

acaaccatcg tgatgtcttc cgctgaggcc gcaaagggag ttctgcagat tcatgatcat      300

ttcctctcaa accgcaaaat ccccgacgca atgcgcggct cctcccacga ccacttctcc      360

cttcctttca tgcctgtttc ccaacagtgg cgagaattgc gaaagctttg caacgaactc      420

ctgttctcca acaagaacct ggacgctaca caaggcctgc gctccaaaaa ggttcgagaa      480

ctgtacagcg atattcaccg cagctcgctg aagggcgagc ccgtgaacat cggtcgtctg      540

gcttttaaaa cgaccatcaa ccaactttct aacaccatct actcggaaga cttcttgcaa      600

tccgccgaga aagcgggcga aatgaaggaa ctcgttacca atattatgaa ggaggttggc      660

cgcccgaacc ttgccgactg cttccccgtt ctgaaaatga tcgaccccca cggcatccgc      720

cgtcgaaccg gctcttactt cagcaagctg cttaatatct tcaaatccct gatccacaag      780

cgtctggaac ttcgtaaaga tgctgcgggc tactgtacta aaaaggatat gcttgacgcg      840

atgctgaacg acgcccaaca caaaatggac atcgttaaga tccagcgtct ctctcttgat      900

ttgttcgttg caggaacgga taccgtcacc tccactgtcg agtgggctat ggctgaactg      960

cttcacaacc cccacgttat gtcaaaggct aaagaggaac tcgaacgcat tatcggtaag     1020

gataatctgg tggaggagtc agacatcgcc aagttgcctt acttgcaggc tatcgtgaag     1080

gagaccttcc gtctccaccc agcagtcccc cttttgctgc cacgcaaagc cgaggttgaa     1140

tttgaaatgc acggttacac aatccccaaa ggcgcccagg tcctgatcaa tgtctgggcc     1200

attggtcgcg acccgaactt gtgggaaaag ccacgcctgt tttggcccga gcgatttctt     1260

gaatccgaga tcgacttcaa gggccgatcg ttcgagctca ccccgttcgg cggcggccgt     1320

cgcatctgcc ctggactccc attggcgatc cgacttgttt ttctgatgct cggcctgttt     1380

attaactctt tcgattggga acttcaggac attcagccgg aagacatgaa tatggacgaa     1440

aacttcggtc tgactcttga aaaggcccag ccagttctcg caattccaat cattccaaaa     1500

cac                                                                   1503


<210>  13
<211>  443
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  13

Met Ser Leu Pro Phe Leu Thr Ser Ala Pro Gly Lys Val Ile Ile Phe 
1               5                   10                  15      


Gly Glu His Ser Ala Val Tyr Asn Lys Pro Ala Val Ala Ala Ser Val 
            20                  25                  30          


Ser Ala Leu Arg Thr Tyr Leu Leu Ile Ser Glu Ser Ser Ala Pro Asp 
        35                  40                  45              


Thr Ile Glu Leu Asp Phe Pro Asp Ile Ser Phe Asn His Lys Trp Ser 
    50                  55                  60                  


Ile Asn Asp Phe Asn Ala Ile Thr Glu Asp Gln Val Asn Ser Gln Lys 
65                  70                  75                  80  


Leu Ala Lys Ala Gln Gln Ala Thr Asp Gly Leu Ser Gln Glu Leu Val 
                85                  90                  95      


Ser Leu Leu Asp Pro Leu Leu Ala Gln Leu Ser Glu Ser Phe His Tyr 
            100                 105                 110         


His Ala Ala Phe Cys Phe Leu Tyr Met Phe Val Cys Leu Cys Pro His 
        115                 120                 125             


Ala Lys Asn Ile Lys Phe Ser Leu Lys Ser Thr Leu Pro Ile Gly Ala 
    130                 135                 140                 


Gly Leu Gly Ser Ser Ala Ser Ile Ser Val Ser Leu Ala Leu Ala Met 
145                 150                 155                 160 


Ala Tyr Leu Gly Gly Leu Ile Gly Ser Asn Asp Leu Glu Lys Leu Ser 
                165                 170                 175     


Glu Asn Asp Lys His Ile Val Asn Gln Trp Ala Phe Ile Gly Glu Lys 
            180                 185                 190         


Cys Ile His Gly Thr Pro Ser Gly Ile Asp Asn Ala Val Ala Thr Tyr 
        195                 200                 205             


Gly Asn Ala Leu Leu Phe Glu Lys Asp Ser His Asn Gly Thr Ile Asn 
    210                 215                 220                 


Thr Asn Asn Phe Lys Phe Leu Asp Asp Phe Pro Ala Ile Pro Met Ile 
225                 230                 235                 240 


Leu Thr Tyr Thr Arg Ile Pro Arg Ser Thr Lys Asp Leu Val Ala Arg 
                245                 250                 255     


Val Arg Val Leu Val Thr Glu Lys Phe Pro Glu Val Met Lys Pro Ile 
            260                 265                 270         


Leu Asp Ala Met Gly Glu Cys Ala Leu Gln Gly Leu Glu Ile Met Thr 
        275                 280                 285             


Lys Leu Ser Lys Cys Lys Gly Thr Asp Asp Glu Ala Val Glu Thr Asn 
    290                 295                 300                 


Asn Glu Leu Tyr Glu Gln Leu Leu Glu Leu Ile Arg Ile Asn His Gly 
305                 310                 315                 320 


Leu Leu Val Ser Ile Gly Val Ser His Pro Gly Leu Glu Leu Ile Lys 
                325                 330                 335     


Asn Leu Ser Asp Asp Leu Arg Ile Gly Ser Thr Lys Leu Thr Gly Ala 
            340                 345                 350         


Gly Gly Gly Gly Cys Ser Leu Thr Leu Leu Arg Arg Asp Ile Thr Gln 
        355                 360                 365             


Glu Gln Ile Asp Ser Phe Lys Lys Lys Leu Gln Asp Asp Phe Ser Tyr 
    370                 375                 380                 


Glu Thr Phe Glu Thr Asp Leu Gly Gly Thr Gly Cys Cys Leu Leu Ser 
385                 390                 395                 400 


Ala Lys Asn Leu Asn Lys Asp Leu Lys Ile Lys Ser Leu Val Phe Gln 
                405                 410                 415     


Leu Phe Glu Asn Lys Thr Thr Thr Lys Gln Gln Ile Asp Asp Leu Leu 
            420                 425                 430         


Leu Pro Gly Asn Thr Asn Leu Pro Trp Thr Ser 
        435                 440             


<210>  14
<211>  1329
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  14
atgtccctgc cattcctcac gtccgcacca ggaaaagtca ttatctttgg cgaacattcc       60

gcagtgtaca acaagcctgc cgtggctgcc tccgtgagcg ccctccgcac ctacttgctg      120

attagcgaga gctctgcccc agataccatc gagctggatt ttccagacat ctcctttaac      180

cataaatggt ccattaacga ttttaacgcg attaccgaag atcaagtcaa cagccagaag      240

ctcgcaaagg cacaacaggc aacagatggc ctctcccagg agcttgtttc cctcctggat      300

ccactgcttg cacagctctc agaatccttt cactaccatg ccgctttctg tttcctgtac      360

atgttcgtgt gtctctgccc ccacgcgaag aacatcaagt tcagcctgaa gtcgacactc      420

cctatcggtg ctggtctcgg atcgtccgcg agcatctcgg tctcgttggc acttgcaatg      480

gcatacctcg gtggtcttat tggttcaaac gatctggaaa agttgtcgga aaacgataaa      540

catattgtga accagtgggc attcatcggc gaaaaatgta tccacggcac ccccagcgga      600

atcgataacg cggttgcaac ctacggaaat gctttgctgt tcgagaagga ttcccacaat      660

ggaacgatta acacgaataa ctttaagttc ctcgacgatt tccccgcaat tcccatgatc      720

ctcacctaca cccgtatccc tcgttcgacc aaagacttgg tcgctcgcgt acgcgtgttg      780

gtcacggaaa agtttccaga ggtcatgaaa cctattcttg atgccatggg tgagtgcgcc      840

cttcagggcc tggagattat gactaagctg tccaagtgca agggtacgga cgacgaggca      900

gtcgaaacta acaatgaact ctacgagcag cttctggaat tgatccgcat caaccacggt      960

ctgctcgtgt ccatcggcgt gtctcaccca ggactggaac tgattaaaaa cctctcggat     1020

gacctccgta tcggctctac caagctgacc ggcgccggag gcggtggatg ctctctcacc     1080

ttgctccgac gcgatatcac ccaggagcag atcgattctt tcaaaaagaa actccaagat     1140

gacttctctt acgagacttt tgagactgac ctcggtggca ccggctgctg cttgctttcc     1200

gcgaagaact tgaataaaga tctcaaaatc aaatctctcg tcttccagct cttcgaaaac     1260

aagaccacca ccaagcaaca gatcgatgac ttgctccttc caggcaacac taaccttcct     1320

tggacaagc                                                             1329


<210>  15
<211>  352
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  15

Met Ala Ser Glu Lys Glu Ile Arg Arg Glu Arg Phe Leu Asn Val Phe 
1               5                   10                  15      


Pro Lys Leu Val Glu Glu Leu Asn Ala Ser Leu Leu Ala Tyr Gly Met 
            20                  25                  30          


Pro Lys Glu Ala Cys Asp Trp Tyr Ala His Ser Leu Asn Tyr Asn Thr 
        35                  40                  45              


Pro Gly Gly Lys Leu Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Ala 
    50                  55                  60                  


Ile Leu Ser Asn Lys Thr Val Glu Gln Leu Gly Gln Glu Glu Tyr Glu 
65                  70                  75                  80  


Lys Val Ala Ile Leu Gly Trp Cys Ile Glu Leu Leu Gln Ala Tyr Trp 
                85                  90                  95      


Leu Val Ala Asp Asp Met Met Asp Lys Ser Ile Thr Arg Arg Gly Gln 
            100                 105                 110         


Pro Cys Trp Tyr Lys Val Pro Glu Val Gly Glu Ile Ala Ile Trp Asp 
        115                 120                 125             


Ala Phe Met Leu Glu Ala Ala Ile Tyr Lys Leu Leu Lys Ser His Phe 
    130                 135                 140                 


Arg Asn Glu Lys Tyr Tyr Ile Asp Ile Thr Glu Leu Phe His Glu Val 
145                 150                 155                 160 


Thr Phe Gln Thr Glu Leu Gly Gln Leu Met Asp Leu Ile Thr Ala Pro 
                165                 170                 175     


Glu Asp Lys Val Asp Leu Ser Lys Phe Ser Leu Lys Lys His Ser Phe 
            180                 185                 190         


Ile Val Thr Phe Lys Thr Ala Tyr Tyr Ser Phe Tyr Leu Pro Val Ala 
        195                 200                 205             


Leu Ala Met Tyr Val Ala Gly Ile Thr Asp Glu Lys Asp Leu Lys Gln 
    210                 215                 220                 


Ala Arg Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe Gln Ile Gln Asp 
225                 230                 235                 240 


Asp Tyr Leu Asp Cys Phe Gly Thr Pro Glu Gln Ile Gly Lys Ile Gly 
                245                 250                 255     


Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Val Ile Asn Lys Ala Leu 
            260                 265                 270         


Glu Leu Ala Ser Ala Glu Gln Arg Lys Thr Leu Asp Glu Asn Tyr Gly 
        275                 280                 285             


Lys Lys Asp Ser Val Ala Glu Ala Lys Cys Lys Lys Ile Phe Asn Asp 
    290                 295                 300                 


Leu Lys Ile Glu Gln Leu Tyr His Glu Tyr Glu Glu Ser Ile Ala Lys 
305                 310                 315                 320 


Asp Leu Lys Ala Lys Ile Ser Gln Val Asp Glu Ser Arg Gly Phe Lys 
                325                 330                 335     


Ala Asp Val Leu Thr Ala Phe Leu Asn Lys Val Tyr Lys Arg Ser Lys 
            340                 345                 350         


<210>  16
<211>  1056
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  16
atggcatccg agaaggaaat ccgtcgtgaa cgattcctga acgtattccc aaagctcgtc       60

gaagagctta atgcttcctt gcttgcgtac ggaatgccga aggaagcgtg cgactggtat      120

gcgcattctc tcaactataa cacacctggc ggtaagctga atcgcggtct cagcgtggtg      180

gacacgtacg caatcctcag caataagacc gtggaacagc tgggacagga ggagtacgag      240

aaagttgcta tccttggatg gtgtatcgaa ctgctgcaag cctattggtt ggtagctgat      300

gacatgatgg ataagagcat cactcgacgt ggtcaaccat gctggtacaa ggtgccggag      360

gttggcgaaa tcgcgatctg ggatgcgttc atgttggagg ccgcaattta taagcttctc      420

aagtcccact ttcgtaacga aaagtactat attgacatca cagaactctt tcatgaagtg      480

accttccaaa ccgagctcgg ccaactcatg gatttgatca ccgcccccga agataaggtg      540

gacctttcga agttctccct caagaagcac tcgttcattg ttaccttcaa gacagcatac      600

tactcatttt acctgccagt cgccctcgca atgtacgtgg cgggcatcac tgatgaaaag      660

gatctgaagc aggcccgcga cgtccttatc cctcttggag agtacttcca gatccaggac      720

gattacttgg attgttttgg caccccagag cagattggta aaatcggtac tgatatccaa      780

gacaacaaat gttcctgggt aattaacaag gctctcgagt tggcttccgc ggaacaacgc      840

aagactcttg acgaaaatta cggtaagaaa gattcagtcg ctgaagccaa gtgcaagaaa      900

atctttaacg atcttaaaat cgaacagttg taccacgagt atgaagagtc tatcgctaaa      960

gacctgaaag ctaaaatttc ccaggtcgat gagtcacgcg gcttcaaagc ggatgtgctc     1020

accgccttcc ttaacaaggt gtataagcgc tccaaa                               1056


<210>  17
<211>  491
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  17

Met Lys Leu Ser Thr Lys Leu Cys Trp Cys Gly Ile Lys Gly Arg Leu 
1               5                   10                  15      


Arg Pro Gln Lys Gln Gln Gln Leu His Asn Thr Asn Leu Gln Met Thr 
            20                  25                  30          


Glu Leu Lys Lys Gln Lys Thr Ala Glu Gln Lys Thr Arg Pro Gln Asn 
        35                  40                  45              


Val Gly Ile Lys Gly Ile Gln Ile Tyr Ile Pro Thr Gln Cys Val Asn 
    50                  55                  60                  


Gln Ser Glu Leu Glu Lys Phe Asp Gly Val Ser Gln Gly Lys Tyr Thr 
65                  70                  75                  80  


Ile Gly Leu Gly Gln Thr Asn Met Ser Phe Val Asn Asp Arg Glu Asp 
                85                  90                  95      


Ile Tyr Ser Met Ser Leu Thr Val Leu Ser Lys Leu Ile Lys Ser Tyr 
            100                 105                 110         


Asn Ile Asp Thr Asn Lys Ile Gly Arg Leu Glu Val Gly Thr Glu Thr 
        115                 120                 125             


Leu Ile Asp Lys Ser Lys Ser Val Lys Ser Val Leu Met Gln Leu Phe 
    130                 135                 140                 


Gly Glu Asn Thr Asp Val Glu Gly Ile Asp Thr Leu Asn Ala Cys Tyr 
145                 150                 155                 160 


Gly Gly Thr Asn Ala Leu Phe Asn Ser Leu Asn Trp Ile Glu Ser Asn 
                165                 170                 175     


Ala Trp Asp Gly Arg Asp Ala Ile Val Val Cys Gly Asp Ile Ala Ile 
            180                 185                 190         


Tyr Asp Lys Gly Ala Ala Arg Pro Thr Gly Gly Ala Gly Thr Val Ala 
        195                 200                 205             


Met Trp Ile Gly Pro Asp Ala Pro Ile Val Phe Asp Ser Val Arg Ala 
    210                 215                 220                 


Ser Tyr Met Glu His Ala Tyr Asp Phe Tyr Lys Pro Asp Phe Thr Ser 
225                 230                 235                 240 


Glu Tyr Pro Tyr Val Asp Gly His Phe Ser Leu Thr Cys Tyr Val Lys 
                245                 250                 255     


Ala Leu Asp Gln Val Tyr Lys Ser Tyr Ser Lys Lys Ala Ile Ser Lys 
            260                 265                 270         


Gly Leu Val Ser Asp Pro Ala Gly Ser Asp Ala Leu Asn Val Leu Lys 
        275                 280                 285             


Tyr Phe Asp Tyr Asn Val Phe His Val Pro Thr Cys Lys Leu Val Thr 
    290                 295                 300                 


Lys Ser Tyr Gly Arg Leu Leu Tyr Asn Asp Phe Arg Ala Asn Pro Gln 
305                 310                 315                 320 


Leu Phe Pro Glu Val Asp Ala Glu Leu Ala Thr Arg Asp Tyr Asp Glu 
                325                 330                 335     


Ser Leu Thr Asp Lys Asn Ile Glu Lys Thr Phe Val Asn Val Ala Lys 
            340                 345                 350         


Pro Phe His Lys Glu Arg Val Ala Gln Ser Leu Ile Val Pro Thr Asn 
        355                 360                 365             


Thr Gly Asn Met Tyr Thr Ala Ser Val Tyr Ala Ala Phe Ala Ser Leu 
    370                 375                 380                 


Leu Asn Tyr Val Gly Ser Asp Asp Leu Gln Gly Lys Arg Val Gly Leu 
385                 390                 395                 400 


Phe Ser Tyr Gly Ser Gly Leu Ala Ala Ser Leu Tyr Ser Cys Lys Ile 
                405                 410                 415     


Val Gly Asp Val Gln His Ile Ile Lys Glu Leu Asp Ile Thr Asn Lys 
            420                 425                 430         


Leu Ala Lys Arg Ile Thr Glu Thr Pro Lys Asp Tyr Glu Ala Ala Ile 
        435                 440                 445             


Glu Leu Arg Glu Asn Ala His Leu Lys Lys Asn Phe Lys Pro Gln Gly 
    450                 455                 460                 


Ser Ile Glu His Leu Gln Ser Gly Val Tyr Tyr Leu Thr Asn Ile Asp 
465                 470                 475                 480 


Asp Lys Phe Arg Arg Ser Tyr Asp Val Lys Lys 
                485                 490     


<210>  18
<211>  1473
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  18
atgaaattgt ctaccaagct ctgttggtgt ggcatcaaag gccgtcttcg cccacagaaa       60

cagcaacagc tgcacaatac caacctccag atgaccgagc ttaaaaagca aaagacggca      120

gagcagaaga ctcgccctca gaatgtcggc attaagggca ttcaaatcta catcccaacc      180

cagtgcgtaa atcagagcga gcttgaaaag ttcgatggag tatcccaggg aaagtataca      240

attggactgg gccagaccaa catgtcgttc gtgaacgacc gcgaagacat ttattcgatg      300

tcgcttactg tgttgagcaa attgatcaaa tcctacaaca ttgatactaa taaaattggt      360

cgcctcgagg tcggcaccga aaccctgatc gataagtcga agagcgtgaa aagcgtgctg      420

atgcaacttt tcggtgagaa caccgatgtg gaaggaatcg atacccttaa cgcatgttac      480

ggtggaacca acgccttgtt taattcgctt aactggatcg aatcgaacgc atgggatggc      540

cgcgatgcaa tcgtggtttg cggagatatc gccatttacg acaagggcgc cgcgcgcccc      600

acgggcggcg cgggcacagt ggcaatgtgg atcggtcctg atgcaccaat tgtgttcgat      660

tcggtccgag caagctatat ggagcatgcc tatgatttct acaaaccaga ttttaccagc      720

gaatacccct acgtcgatgg tcacttctcc ttgacatgct acgtcaaggc gcttgaccag      780

gtgtacaaga gctactccaa aaaggcgatc tccaaaggcc tggtgtccga tcctgcaggt      840

tcagatgctc ttaatgttct taagtatttc gattacaacg ttttccacgt gcccacgtgc      900

aaactcgtga cgaagtcata tggtcgcctc ttgtataacg attttcgagc taatccacag      960

ctttttccgg aagtggacgc agagctggcc acccgcgact acgacgagtc tctcacggat     1020

aagaatatcg aaaaaacttt cgtgaatgtg gctaaaccat tccataagga acgcgtcgca     1080

caatctctca ttgttcccac gaacaccgga aacatgtaca cggcctcagt gtatgctgca     1140

ttcgcgtcac tgcttaacta tgttggatct gatgacctgc aaggtaaacg cgttggactc     1200

ttctcttacg gttcgggttt ggcagcttcg ctgtactcct gcaagattgt cggagacgtc     1260

cagcatatca ttaaagaact ggacattaca aacaagctcg cgaaacgcat cactgaaacg     1320

cccaaggatt acgaagcggc cattgaattg cgcgagaacg cacatttgaa gaaaaacttt     1380

aaaccgcaag gatccatcga acacctgcaa tcgggtgtct attatctcac caacattgac     1440

gataagtttc gacgttccta tgatgttaaa aag                                  1473


<210>  19
<211>  398
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  19

Met Ser Gln Asn Val Tyr Ile Val Ser Thr Ala Arg Thr Pro Ile Gly 
1               5                   10                  15      


Ser Phe Gln Gly Ser Leu Ser Ser Lys Thr Ala Val Glu Leu Gly Ala 
            20                  25                  30          


Val Ala Leu Lys Gly Ala Leu Ala Lys Val Pro Glu Leu Asp Ala Ser 
        35                  40                  45              


Lys Asp Phe Asp Glu Ile Ile Phe Gly Asn Val Leu Ser Ala Asn Leu 
    50                  55                  60                  


Gly Gln Ala Pro Ala Arg Gln Val Ala Leu Ala Ala Gly Leu Ser Asn 
65                  70                  75                  80  


His Ile Val Ala Ser Thr Val Asn Lys Val Cys Ala Ser Ala Met Lys 
                85                  90                  95      


Ala Ile Ile Leu Gly Ala Gln Ser Ile Lys Cys Gly Asn Ala Asp Val 
            100                 105                 110         


Val Val Ala Gly Gly Cys Glu Ser Met Thr Asn Ala Pro Tyr Tyr Met 
        115                 120                 125             


Pro Ala Ala Arg Ala Gly Ala Lys Phe Gly Gln Thr Val Leu Val Asp 
    130                 135                 140                 


Gly Val Glu Arg Asp Gly Leu Asn Asp Ala Tyr Asp Gly Leu Ala Met 
145                 150                 155                 160 


Gly Val His Ala Glu Lys Cys Ala Arg Asp Trp Asp Ile Thr Arg Glu 
                165                 170                 175     


Gln Gln Asp Asn Phe Ala Ile Glu Ser Tyr Gln Lys Ser Gln Lys Ser 
            180                 185                 190         


Gln Lys Glu Gly Lys Phe Asp Asn Glu Ile Val Pro Val Thr Ile Lys 
        195                 200                 205             


Gly Phe Arg Gly Lys Pro Asp Thr Gln Val Thr Lys Asp Glu Glu Pro 
    210                 215                 220                 


Ala Arg Leu His Val Glu Lys Leu Arg Ser Ala Arg Thr Val Phe Gln 
225                 230                 235                 240 


Lys Glu Asn Gly Thr Val Thr Ala Ala Asn Ala Ser Pro Ile Asn Asp 
                245                 250                 255     


Gly Ala Ala Ala Val Ile Leu Val Ser Glu Lys Val Leu Lys Glu Lys 
            260                 265                 270         


Asn Leu Lys Pro Leu Ala Ile Ile Lys Gly Trp Gly Glu Ala Ala His 
        275                 280                 285             


Gln Pro Ala Asp Phe Thr Trp Ala Pro Ser Leu Ala Val Pro Lys Ala 
    290                 295                 300                 


Leu Lys His Ala Gly Ile Glu Asp Ile Asn Ser Val Asp Tyr Phe Glu 
305                 310                 315                 320 


Phe Asn Glu Ala Phe Ser Val Val Gly Leu Val Asn Thr Lys Ile Leu 
                325                 330                 335     


Lys Leu Asp Pro Ser Lys Val Asn Val Tyr Gly Gly Ala Val Ala Leu 
            340                 345                 350         


Gly His Pro Leu Gly Cys Ser Gly Ala Arg Val Val Val Thr Leu Leu 
        355                 360                 365             


Ser Ile Leu Gln Gln Glu Gly Gly Lys Ile Gly Val Ala Ala Ile Cys 
    370                 375                 380                 


Asn Gly Gly Gly Gly Ala Ser Ser Ile Val Ile Glu Lys Ile 
385                 390                 395             


<210>  20
<211>  1194
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  20
atgtcacaga atgtctacat cgtctctacc gcccgcaccc cgattggttc cttccagggt       60

tctcttagct cgaaaacagc ggttgaactc ggcgccgttg cactgaaagg agccttggct      120

aaagtaccag aattggacgc gtccaaggac ttcgatgaaa ttattttcgg taacgtactg      180

tcagctaatc tcggccaagc tccagctcgc caggtcgcgc tcgctgcggg cctctccaat      240

cacattgtgg ccagcactgt gaataaggtc tgcgcatcgg cgatgaaggc gattatcctg      300

ggcgcccaga gcattaaatg cggtaatgca gatgttgtgg ttgccggtgg ctgtgagtcg      360

atgaccaacg ctccgtacta catgcccgct gcacgcgctg gcgctaaatt cggtcaaacc      420

gtcctggtcg atggtgtcga gcgcgatggc ctcaacgatg cgtacgacgg cctcgcgatg      480

ggagtacacg ctgagaagtg tgcccgcgac tgggatatca cccgagagca gcaggacaat      540

tttgccatcg agagctatca gaagtcacaa aagtcacaga aggagggtaa attcgataac      600

gaaatcgttc cagtgacgat caaaggcttc cgcggtaagc cagatactca agtaaccaaa      660

gatgaggaac ctgcccgctt gcacgtagag aagctccgct cggcccgcac tgtcttccag      720

aaagaaaatg gaaccgtgac ggcagctaac gcaagcccta ttaacgacgg tgcggcagcg      780

gtcattctcg tgtcagaaaa ggtgctgaaa gaaaagaacc tcaaacctct ggccatcatc      840

aagggctggg gtgaggccgc tcaccaacct gctgacttca cctgggcacc atccctggct      900

gtaccaaaag cactcaagca cgctggtatt gaagatatca actccgtcga ctacttcgaa      960

tttaatgagg cattctcggt tgtcggcctt gttaacacta agattcttaa gctcgatcca     1020

tccaaggtca atgtatatgg cggtgcggtt gctttgggcc atcctctcgg ttgctcagga     1080

gcccgcgtgg ttgttactct cctcagcatt cttcagcagg agggtggaaa gatcggcgtc     1140

gctgctattt gcaacggcgg tggtggtgcc tcctcaattg ttattgaaaa gatt           1194


<210>  21
<211>  1045
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  21

Met Ser Leu Pro Leu Lys Thr Ile Val His Leu Val Lys Pro Phe Ala 
1               5                   10                  15      


Cys Thr Ala Arg Phe Ser Ala Arg Tyr Pro Ile His Val Ile Val Val 
            20                  25                  30          


Ala Val Leu Leu Ser Ala Ala Ala Tyr Leu Ser Val Thr Gln Ser Tyr 
        35                  40                  45              


Leu Asn Glu Trp Lys Leu Asp Ser Asn Gln Tyr Ser Thr Tyr Leu Ser 
    50                  55                  60                  


Ile Lys Pro Asp Glu Leu Phe Glu Lys Cys Thr His Tyr Tyr Arg Ser 
65                  70                  75                  80  


Pro Val Ser Asp Thr Trp Lys Leu Leu Ser Ser Lys Glu Ala Ala Asp 
                85                  90                  95      


Ile Tyr Thr Pro Phe His Tyr Tyr Leu Ser Thr Ile Ser Phe Gln Ser 
            100                 105                 110         


Lys Asp Asn Ser Thr Thr Leu Pro Ser Leu Asp Asp Val Ile Tyr Ser 
        115                 120                 125             


Val Asp His Thr Arg Tyr Leu Leu Ser Glu Glu Pro Lys Ile Pro Thr 
    130                 135                 140                 


Glu Leu Val Ser Glu Asn Gly Thr Lys Trp Arg Leu Arg Asn Asn Ser 
145                 150                 155                 160 


Asn Phe Ile Leu Asp Leu His Asn Ile Tyr Arg Asn Met Val Lys Gln 
                165                 170                 175     


Phe Ser Asn Lys Thr Ser Glu Phe Asp Gln Phe Asp Leu Phe Ile Ile 
            180                 185                 190         


Leu Ala Ala Tyr Leu Thr Leu Phe Tyr Thr Leu Cys Cys Leu Phe Asn 
        195                 200                 205             


Asp Met Arg Lys Ile Gly Ser Lys Phe Trp Leu Ser Phe Ser Ala Leu 
    210                 215                 220                 


Ser Asn Ser Ala Cys Ala Leu Tyr Leu Ser Leu Tyr Thr Thr His Ser 
225                 230                 235                 240 


Leu Leu Lys Lys Pro Ala Ser Leu Leu Ser Leu Val Ile Gly Leu Pro 
                245                 250                 255     


Phe Ile Val Val Ile Ile Gly Phe Lys His Lys Val Arg Leu Ala Ala 
            260                 265                 270         


Phe Ser Leu Gln Lys Phe His Arg Ile Ser Ile Asp Lys Lys Ile Thr 
        275                 280                 285             


Val Ser Asn Ile Ile Tyr Glu Ala Met Phe Gln Glu Gly Ala Tyr Leu 
    290                 295                 300                 


Ile Arg Asp Tyr Leu Phe Tyr Ile Ser Ser Phe Ile Gly Cys Ala Ile 
305                 310                 315                 320 


Tyr Ala Arg His Leu Pro Gly Leu Val Asn Phe Cys Ile Leu Ser Thr 
                325                 330                 335     


Phe Met Leu Val Phe Asp Leu Leu Leu Ser Ala Thr Phe Tyr Ser Ala 
            340                 345                 350         


Ile Leu Ser Met Lys Leu Glu Ile Asn Ile Ile His Arg Ser Thr Val 
        355                 360                 365             


Ile Arg Gln Thr Leu Glu Glu Asp Gly Val Val Pro Thr Thr Ala Asp 
    370                 375                 380                 


Ile Ile Tyr Lys Asp Glu Thr Ala Ser Glu Pro His Phe Leu Arg Ser 
385                 390                 395                 400 


Asn Val Ala Ile Ile Leu Gly Lys Ala Ser Val Ile Gly Leu Leu Leu 
                405                 410                 415     


Leu Ile Asn Leu Tyr Val Phe Thr Asp Lys Leu Asn Ala Thr Ile Leu 
            420                 425                 430         


Asn Thr Val Tyr Phe Asp Ser Thr Ile Tyr Ser Leu Pro Asn Phe Ile 
        435                 440                 445             


Asn Tyr Lys Asp Ile Gly Asn Leu Ser Asn Gln Val Ile Ile Ser Val 
    450                 455                 460                 


Leu Pro Lys Gln Tyr Tyr Thr Pro Leu Lys Lys Tyr His Gln Ile Glu 
465                 470                 475                 480 


Asp Ser Val Leu Leu Ile Ile Asp Ser Val Ser Asn Ala Ile Arg Asp 
                485                 490                 495     


Gln Phe Ile Ser Lys Leu Leu Phe Phe Ala Phe Ala Val Ser Ile Ser 
            500                 505                 510         


Ile Asn Val Tyr Leu Leu Asn Ala Ala Lys Ile His Thr Gly Tyr Met 
        515                 520                 525             


Asn Phe Gln Pro Gln Ser Asn Lys Ile Asp Asp Leu Val Val Gln Gln 
    530                 535                 540                 


Lys Ser Ala Thr Ile Glu Phe Ser Glu Thr Arg Ser Met Pro Ala Ser 
545                 550                 555                 560 


Ser Gly Leu Glu Thr Pro Val Thr Ala Lys Asp Ile Ile Ile Ser Glu 
                565                 570                 575     


Glu Ile Gln Asn Asn Glu Cys Val Tyr Ala Leu Ser Ser Gln Asp Glu 
            580                 585                 590         


Pro Ile Arg Pro Leu Ser Asn Leu Val Glu Leu Met Glu Lys Glu Gln 
        595                 600                 605             


Leu Lys Asn Met Asn Asn Thr Glu Val Ser Asn Leu Val Val Asn Gly 
    610                 615                 620                 


Lys Leu Pro Leu Tyr Ser Leu Glu Lys Lys Leu Glu Asp Thr Thr Arg 
625                 630                 635                 640 


Ala Val Leu Val Arg Arg Lys Ala Leu Ser Thr Leu Ala Glu Ser Pro 
                645                 650                 655     


Ile Leu Val Ser Glu Lys Leu Pro Phe Arg Asn Tyr Asp Tyr Asp Arg 
            660                 665                 670         


Val Phe Gly Ala Cys Cys Glu Asn Val Ile Gly Tyr Met Pro Ile Pro 
        675                 680                 685             


Val Gly Val Ile Gly Pro Leu Ile Ile Asp Gly Thr Ser Tyr His Ile 
    690                 695                 700                 


Pro Met Ala Thr Thr Glu Gly Cys Leu Val Ala Ser Ala Met Arg Gly 
705                 710                 715                 720 


Cys Lys Ala Ile Asn Ala Gly Gly Gly Ala Thr Thr Val Leu Thr Lys 
                725                 730                 735     


Asp Gly Met Thr Arg Gly Pro Val Val Arg Phe Pro Thr Leu Ile Arg 
            740                 745                 750         


Ser Gly Ala Cys Lys Ile Trp Leu Asp Ser Glu Glu Gly Gln Asn Ser 
        755                 760                 765             


Ile Lys Lys Ala Phe Asn Ser Thr Ser Arg Phe Ala Arg Leu Gln His 
    770                 775                 780                 


Ile Gln Thr Cys Leu Ala Gly Asp Leu Leu Phe Met Arg Phe Arg Thr 
785                 790                 795                 800 


Thr Thr Gly Asp Ala Met Gly Met Asn Met Ile Ser Lys Gly Val Glu 
                805                 810                 815     


Tyr Ser Leu Lys Gln Met Val Glu Glu Tyr Gly Trp Glu Asp Met Glu 
            820                 825                 830         


Val Val Ser Val Ser Gly Asn Tyr Cys Thr Asp Lys Lys Pro Ala Ala 
        835                 840                 845             


Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser Val Val Ala Glu Ala Thr 
    850                 855                 860                 


Ile Pro Gly Asp Val Val Lys Ser Val Leu Lys Ser Asp Val Ser Ala 
865                 870                 875                 880 


Leu Val Glu Leu Asn Ile Ser Lys Asn Leu Val Gly Ser Ala Met Ala 
                885                 890                 895     


Gly Ser Val Gly Gly Phe Asn Ala His Ala Ala Asn Leu Val Thr Ala 
            900                 905                 910         


Leu Phe Leu Ala Leu Gly Gln Asp Pro Ala Gln Asn Val Glu Ser Ser 
        915                 920                 925             


Asn Cys Ile Thr Leu Met Lys Glu Val Asp Gly Asp Leu Arg Ile Ser 
    930                 935                 940                 


Val Ser Met Pro Ser Ile Glu Val Gly Thr Ile Gly Gly Gly Thr Val 
945                 950                 955                 960 


Leu Glu Pro Gln Gly Ala Met Leu Asp Leu Leu Gly Val Arg Gly Pro 
                965                 970                 975     


His Pro Thr Glu Pro Gly Ala Asn Ala Arg Gln Leu Ala Arg Ile Ile 
            980                 985                 990         


Ala Cys Ala Val Leu Ala Gly Glu  Leu Ser Leu Cys Ser  Ala Leu Ala 
        995                 1000                 1005             


Ala Gly  His Leu Val Gln Ser  His Met Thr His Asn  Arg Lys Thr 
    1010                 1015                 1020             


Asn Lys  Ala Asn Glu Leu Pro  Gln Pro Ser Asn Lys  Gly Pro Pro 
    1025                 1030                 1035             


Cys Lys  Thr Ser Ala Leu Leu  
    1040                 1045 


<210>  22
<211>  3135
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  22
atgtccttgc ctcttaagac catcgtgcac ctggtaaagc ctttcgcctg cactgcccgc       60

ttctccgcgc gctaccccat ccacgttatc gtggtggcgg tgctgctctc ggcggcagct      120

tacttgagcg taacccaatc ctacttgaat gaatggaagc tcgactcgaa ccagtactcc      180

acctacctta gcatcaagcc tgatgaattg ttcgaaaaat gtacccacta ctaccgctct      240

ccagtgtctg atacttggaa actccttagc tctaaggaag ctgcagatat ttacaccccc      300

ttccattatt acctgtccac catttccttc cagtccaagg acaactcgac caccctgccc      360

agcctggatg acgttatcta ctccgtagac catacccgct acttgctcag cgaggaaccg      420

aaaatcccga cggaactcgt atccgaaaac ggaaccaagt ggcgtctgcg taataactct      480

aactttatcc ttgatctcca caacatttat cgcaatatgg ttaagcagtt ctcaaacaaa      540

acctcggaat ttgaccaatt cgacttgttc atcattctcg cagcatattt gactttgttt      600

tacaccctct gctgtctctt taatgacatg cgcaaaatcg gctccaagtt ctggctttcc      660

ttctcagctc tttccaacag cgcctgcgca ctttatttga gcttgtacac tacccactcc      720

ctccttaaga aaccagcttc cctcctctcc ctcgtcatcg gcttgccatt catcgtggtt      780

atcattggtt tcaaacataa ggtgcgcctc gctgcgttct ccctgcagaa gtttcaccga      840

attagcatcg ataaaaagat cacggtctct aacattatct acgaagccat gttccaagaa      900

ggcgcgtacc ttatccgaga ttacctgttc tacatttcca gcttcatcgg ttgtgctatc      960

tacgcacgcc accttccagg tctggtgaat ttctgcattc tctccacctt tatgcttgtg     1020

tttgatctcc ttttgagcgc cactttctat agcgcgatcc tctcaatgaa actggaaatc     1080

aacatcattc accgcagcac cgtcattcgc cagacccttg aagaagatgg cgtggtgccg     1140

accaccgccg atattattta taaagatgaa accgcatccg aaccacattt cctgcgttcc     1200

aacgtggcga ttatccttgg taaggcgtcg gtcattggac tgctgctgct gattaatttg     1260

tacgttttca cagataagct caacgcgacg attctgaata ctgtttactt cgattctacc     1320

atctattccc tcccgaactt catcaactat aaggatatcg gaaacctttc taatcaagtc     1380

attattagcg ttctgccaaa gcagtactac acccctttga aaaagtatca tcagattgag     1440

gactctgtgc tccttatcat cgactccgtg agcaatgcta ttcgcgatca atttatctcc     1500

aagctcttgt ttttcgcgtt cgctgtttca atttccatca acgtgtacct gttgaacgca     1560

gctaagattc acacgggcta catgaatttc cagccccaat ccaacaagat tgatgacctt     1620

gtcgtgcaac agaagtctgc aaccattgaa ttctccgaga cccgatccat gcctgcatcc     1680

tccggcctcg agaccccagt taccgcgaag gacatcatta tttcagaaga aatccagaat     1740

aatgaatgcg tatacgcgct gtcatctcag gatgaaccca ttcgcccgtt gtcgaacctt     1800

gttgaactga tggagaaaga gcaactgaaa aatatgaaca acacagaagt ttctaacttg     1860

gtggtgaacg gtaaattgcc gttgtactcc ctggaaaaga aactcgaaga taccacccga     1920

gccgttcttg ttcgacgcaa ggcgctttcc accctggccg aatctccaat ccttgtttcc     1980

gaaaaactcc cttttcgcaa ctacgattac gatcgtgtgt tcggcgcgtg ttgcgagaac     2040

gtaattggct acatgcctat cccagtagga gtgatcggcc ctctcatcat cgatggcacc     2100

agctaccata ttccaatggc aaccacagaa ggttgcttgg tagcaagcgc gatgcgagga     2160

tgcaaagcaa tcaacgctgg aggcggtgct accaccgttc tgaccaagga tggaatgact     2220

cgcggccccg tagtccgctt ccctactctc atccgctctg gtgcgtgcaa gatttggctc     2280

gattccgagg aaggccagaa ctctatcaaa aaagcgttca acagcacctc ccgcttcgcc     2340

cgtttgcaac acattcagac ttgcctggca ggcgacctcc tcttcatgcg tttccgcacc     2400

actactggcg acgcaatggg tatgaacatg atctccaaag gagttgagta ctcgctcaaa     2460

cagatggtgg aagagtatgg ctgggaagac atggaagttg tgtccgtttc cggtaactac     2520

tgcacggaca agaaaccagc tgcgatcaat tggattgagg gacgcggcaa atctgtcgtc     2580

gcggaggcaa ccatcccagg tgacgtcgtc aaatccgttc tcaaatctga cgtctccgca     2640

ctggttgaac tgaacatctc taagaacctt gtgggttctg ctatggctgg cagcgtcggt     2700

ggctttaacg cgcatgcggc gaaccttgtt accgcgctct tcctggcgct cggacaggat     2760

cccgcgcaga atgtggagtc atcaaattgc attacactga tgaaggaggt ggacggcgat     2820

ctgcgtatct ctgtttccat gccgtccatt gaggtgggta ccattggtgg cggcacagtc     2880

ttggagcctc agggtgccat gctggatctg ttgggcgtac gtggccccca tcctaccgaa     2940

ccaggcgcaa acgcacgcca gctcgcgcgc attatcgcat gcgccgtgct ggcaggtgaa     3000

ttgtccctct gctcagcctt ggccgcgggt catttggtcc aaagccacat gacccataac     3060

cgcaaaacga ataaggccaa cgaacttcct caaccttcaa acaagggtcc accttgcaaa     3120

acctccgcgc tgttg                                                      3135


<210>  23
<211>  451
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  23

Met Ser Glu Leu Arg Ala Phe Ser Ala Pro Gly Lys Ala Leu Leu Ala 
1               5                   10                  15      


Gly Gly Tyr Leu Val Leu Asp Thr Lys Tyr Glu Ala Phe Val Val Gly 
            20                  25                  30          


Leu Ser Ala Arg Met His Ala Val Ala His Pro Tyr Gly Ser Leu Gln 
        35                  40                  45              


Gly Ser Asp Lys Phe Glu Val Arg Val Lys Ser Lys Gln Phe Lys Asp 
    50                  55                  60                  


Gly Glu Trp Leu Tyr His Ile Ser Pro Lys Ser Gly Phe Ile Pro Val 
65                  70                  75                  80  


Ser Ile Gly Gly Ser Lys Asn Pro Phe Ile Glu Lys Val Ile Ala Asn 
                85                  90                  95      


Val Phe Ser Tyr Phe Lys Pro Asn Met Asp Asp Tyr Cys Asn Arg Asn 
            100                 105                 110         


Leu Phe Val Ile Asp Ile Phe Ser Asp Asp Ala Tyr His Ser Gln Glu 
        115                 120                 125             


Asp Ser Val Thr Glu His Arg Gly Asn Arg Arg Leu Ser Phe His Ser 
    130                 135                 140                 


His Arg Ile Glu Glu Val Pro Lys Thr Gly Leu Gly Ser Ser Ala Gly 
145                 150                 155                 160 


Leu Val Thr Val Leu Thr Thr Ala Leu Ala Ser Phe Phe Val Ser Asp 
                165                 170                 175     


Leu Glu Asn Asn Val Asp Lys Tyr Arg Glu Val Ile His Asn Leu Ala 
            180                 185                 190         


Gln Val Ala His Cys Gln Ala Gln Gly Lys Ile Gly Ser Gly Phe Asp 
        195                 200                 205             


Val Ala Ala Ala Ala Tyr Gly Ser Ile Arg Tyr Arg Arg Phe Pro Pro 
    210                 215                 220                 


Ala Leu Ile Ser Asn Leu Pro Asp Ile Gly Ser Ala Thr Tyr Gly Ser 
225                 230                 235                 240 


Lys Leu Ala His Leu Val Asp Glu Glu Asp Trp Asn Ile Thr Ile Lys 
                245                 250                 255     


Ser Asn His Leu Pro Ser Gly Leu Thr Leu Trp Met Gly Asp Ile Lys 
            260                 265                 270         


Asn Gly Ser Glu Thr Val Lys Leu Val Gln Lys Val Lys Asn Trp Tyr 
        275                 280                 285             


Asp Ser His Met Pro Glu Ser Leu Lys Ile Tyr Thr Glu Leu Asp His 
    290                 295                 300                 


Ala Asn Ser Arg Phe Met Asp Gly Leu Ser Lys Leu Asp Arg Leu His 
305                 310                 315                 320 


Glu Thr His Asp Asp Tyr Ser Asp Gln Ile Phe Glu Ser Leu Glu Arg 
                325                 330                 335     


Asn Asp Cys Thr Cys Gln Lys Tyr Pro Glu Ile Thr Glu Val Arg Asp 
            340                 345                 350         


Ala Val Ala Thr Ile Arg Arg Ser Phe Arg Lys Ile Thr Lys Glu Ser 
        355                 360                 365             


Gly Ala Asp Ile Glu Pro Pro Val Gln Thr Ser Leu Leu Asp Asp Cys 
    370                 375                 380                 


Gln Thr Leu Lys Gly Val Leu Thr Cys Leu Ile Pro Gly Ala Gly Gly 
385                 390                 395                 400 


Tyr Asp Ala Ile Ala Val Ile Thr Lys Gln Asp Val Asp Leu Arg Ala 
                405                 410                 415     


Gln Thr Ala Asn Asp Lys Arg Phe Ser Lys Val Gln Trp Leu Asp Val 
            420                 425                 430         


Thr Gln Ala Asp Trp Gly Val Arg Lys Glu Lys Asp Pro Glu Thr Tyr 
        435                 440                 445             


Leu Asp Lys 
    450     


<210>  24
<211>  1353
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  24
atgtccgaac tgcgcgcatt ttccgcgcct ggtaaggcgc tgctcgccgg cggctacctt       60

gtgttggaca ctaaatacga ggccttcgtg gtgggccttt ccgcacgtat gcacgccgtc      120

gctcatcctt atggttcgtt gcaaggttcc gataagtttg aggtgcgcgt gaaatccaaa      180

cagtttaaag atggtgaatg gctgtaccac atcagcccaa agtcaggctt cattccagta      240

tccattggtg gttccaagaa tccatttatc gagaaggtca ttgccaacgt cttttcatac      300

ttcaaaccaa acatggatga ttattgtaat cgcaacttgt tcgtgatcga tatcttctct      360

gacgacgctt atcactcgca ggaagattcc gttacggagc atcgtggaaa ccgacgtctg      420

tcatttcatt cgcaccgcat cgaggaagtt cccaagaccg gcctgggctc gtctgccggc      480

cttgtcactg ttttgactac cgccctcgca tctttcttcg tgtctgacct tgaaaacaac      540

gttgataagt accgcgaggt gattcacaac ctggcgcagg tagcgcactg ccaggcgcag      600

ggaaaaattg gcagcggctt tgatgtggct gctgctgcat acggcagcat ccgttaccgc      660

cgcttcccac cagcgcttat tagcaacctg ccggacatcg gctccgcgac ttacggttcc      720

aaattggccc accttgtcga cgaggaagac tggaacatca caatcaagtc taaccacctc      780

ccttccggcc tgacgctctg gatgggcgat atcaagaatg gctctgaaac cgtgaagctc      840

gtgcagaagg ttaagaactg gtacgactca cacatgcctg aatcgttgaa aatctacacc      900

gagcttgatc acgcgaactc ccgtttcatg gacggattgt cgaagttgga ccgtctgcat      960

gaaacgcacg acgattattc cgaccaaatc tttgaatcgc tggaacgtaa cgattgtact     1020

tgtcagaagt atcccgaaat caccgaggtc cgcgacgcgg tcgcgacaat tcgccgctca     1080

ttccgcaaaa tcactaagga atccggtgct gacattgagc ccccggttca gacctccctg     1140

ctcgatgatt gccagactct caagggtgtc ttgacgtgtt tgatccccgg agccggcggc     1200

tacgatgcca tcgcagttat caccaagcag gatgtggatc tccgcgcgca gacagcaaac     1260

gataagcgct tttcaaaggt gcagtggctg gacgtgaccc aagctgattg gggcgttcgt     1320

aaagaaaaag atccagagac atatctggat aag                                  1353


<210>  25
<211>  288
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  25

Met Thr Ala Asp Asn Asn Ser Met Pro His Gly Ala Val Ser Ser Tyr 
1               5                   10                  15      


Ala Lys Leu Val Gln Asn Gln Thr Pro Glu Asp Ile Leu Glu Glu Phe 
            20                  25                  30          


Pro Glu Ile Ile Pro Leu Gln Gln Arg Pro Asn Thr Arg Ser Ser Glu 
        35                  40                  45              


Thr Ser Asn Asp Glu Ser Gly Glu Thr Cys Phe Ser Gly His Asp Glu 
    50                  55                  60                  


Glu Gln Ile Lys Leu Met Asn Glu Asn Cys Ile Val Leu Asp Trp Asp 
65                  70                  75                  80  


Asp Asn Ala Ile Gly Ala Gly Thr Lys Lys Val Cys His Leu Met Glu 
                85                  90                  95      


Asn Ile Glu Lys Gly Leu Leu His Arg Ala Phe Ser Val Phe Ile Phe 
            100                 105                 110         


Asn Glu Gln Gly Glu Leu Leu Leu Gln Gln Arg Ala Thr Glu Lys Ile 
        115                 120                 125             


Thr Phe Pro Asp Leu Trp Thr Asn Thr Cys Cys Ser His Pro Leu Cys 
    130                 135                 140                 


Ile Asp Asp Glu Leu Gly Leu Lys Gly Lys Leu Asp Asp Lys Ile Lys 
145                 150                 155                 160 


Gly Ala Ile Thr Ala Ala Val Arg Lys Leu Asp His Glu Leu Gly Ile 
                165                 170                 175     


Pro Glu Asp Glu Thr Lys Thr Arg Gly Lys Phe His Phe Leu Asn Arg 
            180                 185                 190         


Ile His Tyr Met Ala Pro Ser Asn Glu Pro Trp Gly Glu His Glu Ile 
        195                 200                 205             


Asp Tyr Ile Leu Phe Tyr Lys Ile Asn Ala Lys Glu Asn Leu Thr Val 
    210                 215                 220                 


Asn Pro Asn Val Asn Glu Val Arg Asp Phe Lys Trp Val Ser Pro Asn 
225                 230                 235                 240 


Asp Leu Lys Thr Met Phe Ala Asp Pro Ser Tyr Lys Phe Thr Pro Trp 
                245                 250                 255     


Phe Lys Ile Ile Cys Glu Asn Tyr Leu Phe Asn Trp Trp Glu Gln Leu 
            260                 265                 270         


Asp Asp Leu Ser Glu Val Glu Asn Asp Arg Gln Ile His Arg Met Leu 
        275                 280                 285             


<210>  26
<211>  864
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  26
atgacagcag ataacaattc catgcctcac ggtgctgtgt cttcatacgc gaaactggtg       60

cagaaccaaa cacctgagga tattctcgag gaattccccg aaatcatccc tctccagcag      120

cgcccgaaca cccgctcctc tgaaacctct aatgacgaat ccggcgagac atgtttctcc      180

ggccacgacg aagagcaaat taagctgatg aacgaaaatt gcatcgtgtt ggactgggat      240

gacaacgcca ttggagccgg taccaaaaag gtgtgccatc tgatggagaa cattgaaaag      300

ggactgctcc atcgagcttt ctcagtgttc attttcaatg aacagggtga gctcctgctg      360

caacagcgcg caacggaaaa gattaccttc cccgacctct ggactaacac ctgctgctca      420

cacccattgt gtatcgatga cgaacttggc ttgaagggca agcttgatga taagattaag      480

ggcgcaatca cggccgctgt tcgtaaactc gatcacgaac ttggaattcc tgaagacgaa      540

accaagactc gcggcaaatt tcacttcttg aatcgtatcc actatatggc gccttccaac      600

gagccttggg gcgagcacga gatcgactat attttgttct acaagatcaa tgcaaaggag      660

aacctgactg tgaacccgaa tgtgaatgaa gtgcgtgact tcaagtgggt ctcaccgaac      720

gatctgaaga ccatgtttgc cgatccatcc tacaaattca ccccgtggtt caaaattatc      780

tgtgaaaact atctgttcaa ttggtgggaa caactcgacg atttgtccga ggtcgagaac      840

gatcgtcaaa tccaccgtat gctt                                             864


<210>  27
<211>  527
<212>  PRT
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  27

Met Ala Ala Asp Gln Leu Val Lys Thr Glu Val Thr Lys Lys Ser Phe 
1               5                   10                  15      


Thr Ala Pro Val Gln Lys Ala Ser Thr Pro Val Leu Thr Asn Lys Thr 
            20                  25                  30          


Val Ile Ser Gly Ser Lys Val Lys Ser Leu Ser Ser Ala Gln Ser Ser 
        35                  40                  45              


Ser Ser Gly Pro Ser Ser Ser Ser Glu Glu Asp Asp Ser Arg Asp Ile 
    50                  55                  60                  


Glu Ser Leu Asp Lys Lys Ile Arg Pro Leu Glu Glu Leu Glu Ala Leu 
65                  70                  75                  80  


Leu Ser Ser Gly Asn Thr Lys Gln Leu Lys Asn Lys Glu Val Ala Ala 
                85                  90                  95      


Leu Val Ile His Gly Lys Leu Pro Leu Tyr Ala Leu Glu Lys Lys Leu 
            100                 105                 110         


Gly Asp Thr Thr Arg Ala Val Ala Val Arg Arg Lys Ala Leu Ser Ile 
        115                 120                 125             


Leu Ala Glu Ala Pro Val Leu Ala Ser Asp Arg Leu Pro Tyr Lys Asn 
    130                 135                 140                 


Tyr Asp Tyr Asp Arg Val Phe Gly Ala Cys Cys Glu Asn Val Ile Gly 
145                 150                 155                 160 


Tyr Met Pro Leu Pro Val Gly Val Ile Gly Pro Leu Val Ile Asp Gly 
                165                 170                 175     


Thr Ser Tyr His Ile Pro Met Ala Thr Thr Glu Gly Cys Leu Val Ala 
            180                 185                 190         


Ser Ala Met Arg Gly Cys Lys Ala Ile Asn Ala Gly Gly Gly Ala Thr 
        195                 200                 205             


Thr Val Leu Thr Lys Asp Gly Met Thr Arg Gly Pro Val Val Arg Phe 
    210                 215                 220                 


Pro Thr Leu Lys Arg Ser Gly Ala Cys Lys Ile Trp Leu Asp Ser Glu 
225                 230                 235                 240 


Glu Gly Gln Asn Ala Ile Lys Lys Ala Phe Asn Ser Thr Ser Arg Phe 
                245                 250                 255     


Ala Arg Leu Gln His Ile Gln Thr Cys Leu Ala Gly Asp Leu Leu Phe 
            260                 265                 270         


Met Arg Phe Arg Thr Thr Thr Gly Asp Ala Met Gly Met Asn Met Ile 
        275                 280                 285             


Ser Lys Gly Val Glu Tyr Ser Leu Lys Gln Met Val Glu Glu Tyr Gly 
    290                 295                 300                 


Trp Glu Asp Met Glu Val Val Ser Val Ser Gly Asn Tyr Cys Thr Asp 
305                 310                 315                 320 


Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser Val 
                325                 330                 335     


Val Ala Glu Ala Thr Ile Pro Gly Asp Val Val Arg Lys Val Leu Lys 
            340                 345                 350         


Ser Asp Val Ser Ala Leu Val Glu Leu Asn Ile Ala Lys Asn Leu Val 
        355                 360                 365             


Gly Ser Ala Met Ala Gly Ser Val Gly Gly Phe Asn Ala His Ala Ala 
    370                 375                 380                 


Asn Leu Val Thr Ala Val Phe Leu Ala Leu Gly Gln Asp Pro Ala Gln 
385                 390                 395                 400 


Asn Val Glu Ser Ser Asn Cys Ile Thr Leu Met Lys Glu Val Asp Gly 
                405                 410                 415     


Asp Leu Arg Ile Ser Val Ser Met Pro Ser Ile Glu Val Gly Thr Ile 
            420                 425                 430         


Gly Gly Gly Thr Val Leu Glu Pro Gln Gly Ala Met Leu Asp Leu Leu 
        435                 440                 445             


Gly Val Arg Gly Pro His Ala Thr Ala Pro Gly Thr Asn Ala Arg Gln 
    450                 455                 460                 


Leu Ala Arg Ile Val Ala Cys Ala Val Leu Ala Gly Glu Leu Ser Leu 
465                 470                 475                 480 


Cys Ala Ala Leu Ala Ala Gly His Leu Val Gln Ser His Met Thr His 
                485                 490                 495     


Asn Arg Lys Pro Ala Glu Pro Thr Lys Pro Asn Asn Leu Asp Ala Thr 
            500                 505                 510         


Asp Ile Asn Arg Leu Lys Asp Gly Ser Val Thr Cys Ile Lys Ser 
        515                 520                 525         


<210>  28
<211>  1581
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  28
atggcggctg atcagctcgt taaaacggaa gtaacaaaga aatccttcac cgctcccgta       60

cagaaagctt ctactcctgt cttgaccaac aagaccgtta tctccggctc taaagtgaaa      120

tcgctctctt ccgcccagag cagctcatcc ggtccgtcgt cttcctccga agaggacgac      180

tcacgtgata ttgaatcact ggataaaaag attcgaccgc tcgaagagct tgaggcgctt      240

ttgagctccg gcaataccaa acagttgaag aacaaggagg ttgccgccct tgtgattcac      300

ggcaaacttc cgctctatgc cttggagaag aagttgggag acaccacgcg cgcagtggcc      360

gtgcgccgca aggcactgtc tattctcgcg gaggcacccg tcctggcttc cgaccgcttg      420

ccctacaaga actacgatta cgaccgtgtc ttcggcgcat gttgcgagaa tgtaatcgga      480

tatatgcccc ttcccgttgg cgtgatcggc ccacttgtca tcgatggcac atcataccat      540

attccaatgg cgaccaccga gggttgcctc gtggcgtcgg ccatgcgcgg ttgtaaggcc      600

atcaacgccg gaggtggagc aactaccgta cttactaagg acggcatgac tcgtggcccc      660

gtggtgcgtt tcccgactct taaacgctcc ggtgcgtgca agatctggtt ggattccgag      720

gagggacaga acgcaatcaa aaaagctttc aacagcactt ctcgcttcgc tcgacttcag      780

cacattcaga cctgtctcgc tggtgacttg ttgttcatgc gttttcgcac caccactgga      840

gacgcgatgg gcatgaatat gattagcaaa ggagtggaat actccctcaa acaaatggtg      900

gaagaatatg gctgggaaga catggaagtg gtttccgtgt ctggtaatta ttgtaccgac      960

aagaagccgg cagccatcaa ctggattgag ggccgtggca agtccgtggt ggcggaggcg     1020

acaattccgg gtgatgtcgt gcgcaaagtt ctcaagtctg acgtgtcagc gttggtagaa     1080

ctgaacatcg caaaaaacct tgtaggatcg gcaatggctg gttcagtggg cggttttaat     1140

gcgcacgcag ccaacctcgt caccgctgtg ttccttgccc tgggtcagga tccagcacag     1200

aatgtggaaa gctcgaactg catcaccctg atgaaagaag tggatggcga cttgcgtatc     1260

tccgtctcga tgccatcaat cgaagtgggt accatcggtg gcggaaccgt gttggaacca     1320

cagggagcaa tgcttgatct cctcggcgtt cgaggtccgc acgccacggc gcccggcacc     1380

aacgcacgtc agctggcacg catcgtggct tgcgcggttc tcgcgggtga attgagcctc     1440

tgcgcagccc tggcagcggg tcacctggtg caatctcaca tgacacataa ccgtaaacca     1500

gccgagccca ccaagccgaa taacctcgac gccactgata ttaaccgctt gaaggatggt     1560

tccgtcacct gcatcaaatc t                                               1581


<210>  29
<211>  425
<212>  PRT
<213>  Staphylococcus aureus

<400>  29

Met Gln Ser Leu Asp Lys Asn Phe Arg His Leu Ser Arg Gln Gln Lys 
1               5                   10                  15      


Leu Gln Gln Leu Val Asp Lys Gln Trp Leu Ser Glu Asp Gln Phe Asp 
            20                  25                  30          


Ile Leu Leu Asn His Pro Leu Ile Asp Glu Glu Val Ala Asn Ser Leu 
        35                  40                  45              


Ile Glu Asn Val Ile Ala Gln Gly Ala Leu Pro Val Gly Leu Leu Pro 
    50                  55                  60                  


Asn Ile Ile Val Asp Asp Lys Ala Tyr Val Val Pro Met Met Val Glu 
65                  70                  75                  80  


Glu Pro Ser Val Val Ala Ala Ala Ser Tyr Gly Ala Lys Leu Val Asn 
                85                  90                  95      


Gln Thr Gly Gly Phe Lys Thr Val Ser Ser Glu Arg Ile Met Ile Gly 
            100                 105                 110         


Gln Ile Val Phe Asp Gly Val Asp Asp Thr Glu Lys Leu Ser Ala Asp 
        115                 120                 125             


Ile Lys Ala Leu Glu Lys Gln Ile His Lys Ile Ala Asp Glu Ala Tyr 
    130                 135                 140                 


Pro Ser Ile Lys Ala Arg Gly Gly Gly Tyr Gln Arg Ile Ala Ile Asp 
145                 150                 155                 160 


Thr Phe Pro Glu Gln Gln Leu Leu Ser Leu Lys Val Phe Val Asp Thr 
                165                 170                 175     


Lys Asp Ala Met Gly Ala Asn Met Leu Asn Thr Ile Leu Glu Ala Ile 
            180                 185                 190         


Thr Ala Phe Leu Lys Asn Glu Ser Pro Gln Ser Asp Ile Leu Met Ser 
        195                 200                 205             


Ile Leu Ser Asn His Ala Thr Ala Ser Val Val Lys Val Gln Gly Glu 
    210                 215                 220                 


Ile Asp Val Lys Asp Leu Ala Arg Gly Glu Arg Thr Gly Glu Glu Val 
225                 230                 235                 240 


Ala Lys Arg Met Glu Arg Ala Ser Val Leu Ala Gln Val Asp Ile His 
                245                 250                 255     


Arg Ala Ala Thr His Asn Lys Gly Val Met Asn Gly Ile His Ala Val 
            260                 265                 270         


Val Leu Ala Thr Gly Asn Asp Thr Arg Gly Ala Glu Ala Ser Ala His 
        275                 280                 285             


Ala Tyr Ala Ser Arg Asp Gly Gln Tyr Arg Gly Ile Ala Thr Trp Arg 
    290                 295                 300                 


Tyr Asp Gln Lys Arg Gln Arg Leu Ile Gly Thr Ile Glu Val Pro Met 
305                 310                 315                 320 


Thr Leu Ala Ile Val Gly Gly Gly Thr Lys Val Leu Pro Ile Ala Lys 
                325                 330                 335     


Ala Ser Leu Glu Leu Leu Asn Val Asp Ser Ala Gln Glu Leu Gly His 
            340                 345                 350         


Val Val Ala Ala Val Gly Leu Ala Gln Asn Phe Ala Ala Cys Arg Ala 
        355                 360                 365             


Leu Val Ser Glu Gly Ile Gln Gln Gly His Met Ser Leu Gln Tyr Lys 
    370                 375                 380                 


Ser Leu Ala Ile Val Val Gly Ala Lys Gly Asp Glu Ile Ala Gln Val 
385                 390                 395                 400 


Ala Glu Ala Leu Lys Gln Glu Pro Arg Ala Asn Thr Gln Val Ala Glu 
                405                 410                 415     


Arg Ile Leu Gln Glu Ile Arg Gln Gln 
            420                 425 


<210>  30
<211>  1275
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  30
atgcaatccc tcgataaaaa tttccgtcac ctttctcgac agcagaaatt gcagcaactt       60

gttgacaagc aatggctctc ggaggatcaa ttcgatatcc tgctcaatca cccactgatc      120

gatgaggagg tcgccaattc cctgattgag aacgtcatcg cgcagggtgc actgcccgtg      180

ggccttctgc ctaacatcat cgtcgatgac aaggcctacg tagtacctat gatggtcgaa      240

gaaccgtccg tggtggcagc tgcttcctat ggtgccaagc tggtcaacca gaccggcgga      300

ttcaagactg tgtcttctga acgcattatg atcggacaga ttgtcttcga tggtgttgat      360

gatacggaaa agctctctgc agacatcaag gcattggaga aacagatcca taaaatcgcg      420

gatgaggcgt acccctccat caaagcgcgc ggcggcggct atcagcgaat cgctattgac      480

accttccctg aacagcagct gctctccctg aaagtcttcg tggatactaa ggacgccatg      540

ggtgcaaata tgttgaacac catcctggag gccatcaccg cgttcctgaa gaacgagagc      600

cctcagtcgg atattttgat gtcaatcctg tccaatcacg ccactgcatc tgtggtaaaa      660

gtgcaaggtg aaatcgatgt caaagatctc gcccgcggag aacgcacggg cgaagaggtc      720

gcaaaacgaa tggagcgcgc ctctgttctt gcgcaggtgg atatccaccg cgctgcgacc      780

cacaataaag gtgtgatgaa cggcatccat gcagtcgtac ttgccaccgg caacgatact      840

cgcggtgcag aagcgtctgc ccatgcatat gcgtcgcgag atggtcaata ccgtggcatt      900

gctacatggc gttacgatca aaaacgccag cgtctcattg gtacgatcga ggttcctatg      960

accctggcca tcgtcggcgg aggcaccaaa gtcctcccga tcgcaaaggc ctcgctcgaa     1020

cttttgaatg tcgatagcgc acaagaactc ggtcacgtcg tagcagccgt gggtctggcg     1080

cagaacttcg cagcgtgtcg agcacttgtc tccgagggca ttcagcaggg tcacatgtcc     1140

cttcagtaca aaagcttggc aattgttgtg ggtgcaaagg gtgatgagat tgcccaggtc     1200

gcagaagcac tcaaacaaga gccacgtgcg aacacgcagg ttgccgagcg tatccttcaa     1260

gaaattcgac aacaa                                                      1275


<210>  31
<211>  446
<212>  PRT
<213>  Candidatus Halobonum tyrrellensis G22

<400>  31

Met Ser Asp Ala Asp Thr Glu Arg Leu Ala Ala Arg Val Arg Glu Gly 
1               5                   10                  15      


Asp Leu Arg Leu Tyr Glu Leu Glu Glu His Ala Asp Ala Asp Thr Ala 
            20                  25                  30          


Val Ala Ala Arg Arg Leu Leu Val Glu Glu Ala Ser Gly Ala Glu Leu 
        35                  40                  45              


Glu Thr Thr Gly Glu Tyr Ala Phe Pro Ala Glu Met Ala Thr Gly Thr 
    50                  55                  60                  


Asn Val Glu Asn Met Val Gly Ala Val Gln Val Pro Val Gly Val Val 
65                  70                  75                  80  


Gly Pro Val Thr Ile Asp Gly Gly Ala Leu Ser Gly Glu Arg His Val 
                85                  90                  95      


Pro Met Ala Thr Thr Glu Gly Ala Leu Leu Ala Ser Val Asn Arg Gly 
            100                 105                 110         


Cys Ser Ala Leu Asn Thr Ala Gly Gly Ala Ser Ala Arg Val Leu Lys 
        115                 120                 125             


Asn Arg Met Thr Arg Ala Pro Val Phe Arg Val Asp Gly Val Val Glu 
    130                 135                 140                 


Ala Glu Ala Leu Ala Ser Trp Thr Arg Asp Asn Val Glu Ala Leu Arg 
145                 150                 155                 160 


Ala Val Ala Glu Ala Thr Thr Asn His Gly Glu Leu Arg Glu Val Arg 
                165                 170                 175     


Pro Tyr Ala Val Gly Asn Asn Val Tyr Leu Arg Phe Ala Tyr Asp Thr 
            180                 185                 190         


Lys Asp Ala Met Gly Met Asn Met Ala Thr Ile Ala Thr Glu Ala Ala 
        195                 200                 205             


Cys Glu Val Val Glu Asp Glu Thr Gly Ala Glu Leu Val Ala Leu Ser 
    210                 215                 220                 


Gly Asn Leu Cys Ser Asp Lys Lys Pro Ala Ala Val Asn Ala Val Glu 
225                 230                 235                 240 


Gly Arg Gly Arg Thr Val Ala Ala Asp Val Thr Val Pro Arg Glu Thr 
                245                 250                 255     


Val Arg Glu Thr Leu Lys Thr Thr Pro Glu Ala Val Ala Glu Val Asn 
            260                 265                 270         


Thr Arg Lys Asn Leu Val Gly Ser Ala Lys Ala Gly Ser Leu Gly Phe 
        275                 280                 285             


Asn Ala His Val Ala Asn Ala Val Ala Ala Val Phe Leu Ala Thr Gly 
    290                 295                 300                 


Gln Asp Ala Ala Gln Val Val Glu Gly Ala Asn Ala Ile Thr Thr Ala 
305                 310                 315                 320 


Glu Val Val Ala Gly Asp Ala Pro Ser Arg Thr Val Asp Arg Asn Gly 
                325                 330                 335     


Ala Ala Glu Ser Gly Val Gly Pro Asp Gly Asp Ala Pro Asp Gly Asp 
            340                 345                 350         


Ala Pro Asp Gly Asp Gly Ala Ala Ala Gly Arg Gly Gly Asp Leu Tyr 
        355                 360                 365             


Val Ser Val Thr Leu Ala Ser Leu Glu Val Gly Thr Val Gly Gly Gly 
    370                 375                 380                 


Thr Lys Leu Pro Thr Gln Ala Glu Ala Leu Asp Val Leu Gly Val Arg 
385                 390                 395                 400 


Gly Gly Gly Asp Pro Ala Gly Ser Asn Ala Asp Ala Leu Ala Glu Ala 
                405                 410                 415     


Val Ala Val Thr Ala Leu Ala Gly Glu Leu Ser Leu Leu Ser Ala Leu 
            420                 425                 430         


Ala Ser Arg Asn Leu Ser Ser Ala His Ala Glu Leu Gly Arg 
        435                 440                 445     


<210>  32
<211>  1338
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  32
atgtcagacg ctgacaccga gcgtctggct gcgcgcgttc gcgagggtga tctgcgcctg       60

tatgagctgg aggagcacgc ggatgcagat actgctgtcg ccgctcgtcg tctcttggtg      120

gaagaggcct ccggtgcaga acttgagact accggtgaat atgctttccc tgcagaaatg      180

gcaaccggca ccaatgtcga gaacatggtc ggtgctgttc aggttccagt gggcgtagtg      240

ggtcctgtta cgattgatgg cggtgcgctg tctggcgagc gtcacgtccc aatggctaca      300

accgaaggtg cgctcctcgc gtccgtcaat cgcggctgct cggccctcaa cacagctggt      360

ggtgcatcag ctcgtgtcct gaagaatcgc atgactcgtg cccccgtctt tcgcgtcgat      420

ggcgtcgtcg aagccgaggc gcttgcttcg tggacccgcg acaacgtgga agcgctccgt      480

gcagtggctg aagctaccac caaccacgga gaactccgcg aagtgcgccc atacgctgtg      540

ggcaacaacg tctaccttcg attcgcttat gataccaagg atgcaatggg catgaatatg      600

gccactatcg ccaccgaggc ggcgtgcgag gtggtggaag atgaaaccgg cgctgagctg      660

gttgcactga gcggtaacct ttgctctgat aagaagccag ccgctgtgaa cgcagtggaa      720

ggtcgcggtc gcacagttgc tgctgatgtg acggttcctc gcgagaccgt tcgcgagacc      780

ctgaagacca cccctgaggc cgtggccgag gttaacacgc gcaagaactt ggtgggaagc      840

gcgaaggccg gctcattggg atttaatgct catgtggcaa acgccgtggc agcagtcttt      900

cttgcaacag gtcaggatgc tgcgcaggtc gtggaaggtg ctaacgccat cactacggcg      960

gaagtcgtcg caggcgatgc tccatcccgt accgtggatc gcaatggcgc tgctgaatcc     1020

ggcgtaggtc cggatggtga tgcacctgac ggtgatgcac cggatggtga cggcgcagca     1080

gcaggtcgtg gcggcgacct ctatgttagc gtgaccctgg cctcactgga ggtcggtacc     1140

gtgggcggcg gtacgaaact gcccacccaa gcggaagcat tggacgtgct cggtgtacgt     1200

ggaggaggtg atcctgctgg tagcaacgca gatgctctcg ctgaagccgt tgctgtgacc     1260

gctttggctg gtgagttgtc tcttctttcc gctctcgcca gccgtaacct ctcgtcggca     1320

cacgctgaac tgggacgc                                                   1338


<210>  33
<211>  665
<212>  PRT
<213>  Cucumis sativus (Cucumber)

<400>  33

Met Thr His Cys Ser Gln Leu Pro Thr His Lys Ala Thr Thr Thr Glu 
1               5                   10                  15      


Lys Asn Asp Glu Pro Ile Pro Leu Gly Pro Val Gln Leu Ser Trp Pro 
            20                  25                  30          


Gly Ser Val Val Glu Lys Gly Glu Lys Ser Ser Phe His Tyr Lys Pro 
        35                  40                  45              


Pro Phe Ala Ser Arg Ser Gly Ala Gly Val Phe His Phe Leu Phe Phe 
    50                  55                  60                  


Ser Cys Leu Thr Met Asp Ala Arg Arg Arg Arg Ser Ser Thr Leu Val 
65                  70                  75                  80  


Lys Lys Leu Thr Ala Asp Glu Pro Pro Val Lys Ser Met Asp Lys Asn 
                85                  90                  95      


Pro Leu Lys Val Lys Met Leu Glu Arg Gln His Val His Asp Asp Ala 
            100                 105                 110         


Val Lys Ala Ser Asp Val Leu Pro Leu Pro Ile Tyr Leu Thr Asn Ala 
        115                 120                 125             


Ala Phe Phe Thr Leu Phe Phe Ser Val Val Tyr Phe Leu Leu Thr Arg 
    130                 135                 140                 


Trp Arg Glu Lys Ile Arg Ser Ser Thr Pro Leu His Val Val Thr Leu 
145                 150                 155                 160 


Ser Glu Met Val Ala Ile Ser Ala Phe Ile Ala Ser Phe Ile Tyr Leu 
                165                 170                 175     


Leu Gly Phe Phe Gly Ile Asp Phe Val Gln Ser Ile Phe Arg Pro Ser 
            180                 185                 190         


His Asp Val Trp Thr Ser Glu Asp Asp Glu Val Val Ile Ile Lys Glu 
        195                 200                 205             


Asp Thr Arg Lys Val Pro Cys Gly Ala Gly Ile Asp Cys Ser Ile Pro 
    210                 215                 220                 


Ile Leu Ala Pro Pro Met Pro Ser Val Pro Lys Val Val Asp Pro Leu 
225                 230                 235                 240 


Pro Val Ser Ile Asp Leu Thr Glu Glu Asp Glu Glu Ile Val Lys Ser 
                245                 250                 255     


Val Val Asp Gly Ser Thr Pro Ser Tyr Ser Leu Glu Ser Lys Leu Gly 
            260                 265                 270         


Asp Cys Gly Arg Ala Ala Ala Ile Arg Arg Val Ala Leu Gln Arg Val 
        275                 280                 285             


Thr Gly Lys Ser Leu Ser Gly Leu Pro Leu Glu Gly Phe Asp Tyr Ala 
    290                 295                 300                 


Ser Ile Leu Gly Gln Cys Cys Glu Met Pro Ile Gly Tyr Val Gln Ile 
305                 310                 315                 320 


Pro Val Gly Ile Ala Gly Pro Leu Leu Leu Asp Gly Lys Glu Tyr Ser 
                325                 330                 335     


Val Pro Met Ala Thr Thr Glu Gly Cys Leu Val Ala Ser Thr Asn Arg 
            340                 345                 350         


Gly Cys Lys Ala Ile Met Ile Ser Gly Gly Ala Asn Ser Val Leu Leu 
        355                 360                 365             


Arg Asp Ala Met Thr Arg Ala Pro Val Met Arg Phe Ala Thr Ala Lys 
    370                 375                 380                 


Arg Ala Ala Glu Leu Lys Phe Tyr Val Glu Asp Pro Ala Asn Phe Asp 
385                 390                 395                 400 


Thr Leu Ala Ser Val Phe Asn Lys Ser Ser Arg Phe Gly Arg Leu Gln 
                405                 410                 415     


Ser Ile Lys Cys Ala Ile Ala Gly Lys Asn Leu Tyr Met Arg Phe Ser 
            420                 425                 430         


Cys Ser Thr Gly Asp Ala Met Gly Met Asn Met Val Ser Lys Gly Val 
        435                 440                 445             


Gln Asn Val Leu Asp Phe Leu Gln Asn Asp Phe Pro Asp Met Asp Val 
    450                 455                 460                 


Ile Gly Ile Ser Gly Asn Tyr Cys Ser Asp Lys Lys Pro Ala Ala Val 
465                 470                 475                 480 


Asn Trp Ile Glu Gly Arg Gly Lys Ser Val Val Cys Glu Val Thr Ile 
                485                 490                 495     


Lys Gly Asp Val Val Arg Lys Val Leu Lys Thr Asp Val Gln Ala Leu 
            500                 505                 510         


Val Glu Leu Asn Met Leu Lys Asn Leu Thr Gly Ser Ala Met Ala Gly 
        515                 520                 525             


Ala Leu Gly Gly Phe Asn Ala His Ala Ser Asn Ile Val Ser Ala Ile 
    530                 535                 540                 


Tyr Ile Ala Thr Gly Gln Asp Pro Ala Gln Asn Val Glu Ser Ser His 
545                 550                 555                 560 


Cys Ile Thr Met Met Glu Ala Val Asn Asp Gly Gln Asp Leu His Val 
                565                 570                 575     


Ser Val Thr Met Pro Ser Ile Glu Val Gly Thr Val Gly Gly Gly Thr 
            580                 585                 590         


Gln Leu Ala Ser Gln Ser Ala Cys Leu Asn Leu Leu Gly Val Lys Gly 
        595                 600                 605             


Ala Asn Arg Glu Ala Pro Gly Ser Asn Ser Arg Leu Leu Ala Thr Ile 
    610                 615                 620                 


Val Ala Ala Ser Val Leu Ala Gly Glu Leu Ser Leu Met Ser Ala Ile 
625                 630                 635                 640 


Ser Ala Gly Gln Leu Val Arg Ser His Met Lys Tyr Asn Arg Ser Ser 
                645                 650                 655     


Arg Asp Ile Thr Lys Ala Ser Ser Ser 
            660                 665 


<210>  34
<211>  1995
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  34
atgacccatt gctcccagtt gccgacccac aaggcgacga cgactgaaaa aaacgatgag       60

cctattcccc ttggccccgt gcaactgagc tggccgggtt ccgttgttga aaagggagaa      120

aagtcatcgt tccattataa gcccccattc gcgtctcgca gcggcgcagg cgtatttcat      180

tttctctttt tctcgtgctt gactatggac gcccgtcgcc gtcgctcttc gactctggtg      240

aagaaactta ctgcggatga gcctccagta aaatctatgg ataaaaatcc tcttaaagtc      300

aagatgcttg aacgacagca tgtccatgac gatgccgtaa aggcgtcgga tgtgctccca      360

ctgccaatct accttactaa cgctgcattc ttcactctgt tcttttccgt ggtatatttc      420

cttcttacgc gctggcgtga gaagattcgt agctccacgc ccctgcacgt agtaaccctc      480

tcagaaatgg tggctatctc tgccttcatc gcctcgttca tttacctgct tggctttttc      540

ggcattgatt tcgtgcagtc catcttccgc ccctcccacg atgtctggac ctcagaggac      600

gacgaagtgg tcatcatcaa agaagacact cgcaaggtcc catgtggcgc cggaattgac      660

tgttccattc caattctggc ccctcctatg ccctcggtgc cgaaggtggt tgatccgctg      720

cctgtgtcca ttgatctcac cgaggaggat gaagagattg tgaagtcagt cgtcgacggc      780

tcgacacctt cttactcatt ggagtctaag ctcggagatt gtggccgagc ggctgctatc      840

cgacgtgttg cacttcagcg cgtgactggc aagtcgctgt ctggcctccc gctggagggc      900

ttcgactatg cttccatcct cggacagtgt tgcgagatgc ccattggcta cgtgcaaatt      960

cccgtgggaa ttgccggccc attgcttttg gatggtaagg aatacagcgt ccccatggcg     1020

acgaccgaag gatgccttgt ggcctccacc aaccgaggct gcaaggcgat catgatctcc     1080

ggaggcgcta actccgtcct ccttcgtgat gccatgacac gtgcgccagt gatgcgcttt     1140

gcgactgcta agcgcgccgc ggaactcaaa ttctacgttg aagacccggc taacttcgat     1200

acccttgcct ccgtatttaa caaatctagc cgctttggac gcctgcagag catcaaatgt     1260

gccatcgccg gcaaaaacct ctatatgcga ttttcgtgct ccactggcga cgctatggga     1320

atgaatatgg tttccaaggg cgtacagaac gttctggact ttctccagaa tgattttcca     1380

gacatggatg taatcggaat cagcggaaac tattgttcag ataagaagcc agccgccgtt     1440

aattggatcg aaggacgcgg caagtccgtc gtgtgcgagg ttaccatcaa aggcgatgtt     1500

gtccgcaagg tcctgaagac agatgtccag gcactggtgg aactcaacat gttgaaaaat     1560

cttacgggtt ccgcaatggc tggcgcactt ggtggcttta acgctcatgc atccaacatc     1620

gtttcagcca tctacatcgc gacgggacag gatcccgctc aaaacgtgga aagctcccat     1680

tgcatcacta tgatggaggc cgtaaacgat ggtcaggatc ttcacgtgag cgtgaccatg     1740

ccatccatcg aggtgggaac cgtaggcggt ggcacgcaac tggcatccca gtccgcctgc     1800

ctgaacctct tgggtgttaa gggcgcgaat cgcgaagctc caggttcaaa ttctcgcttg     1860

ctcgccacca ttgtggccgc atcagttctt gcaggcgaac ttagcctcat gtcagcgatc     1920

tccgccggcc aactcgtccg cagccacatg aaatacaatc gttcatcacg cgatatcacc     1980

aaggcttcat catcc                                                      1995


<210>  35
<211>  428
<212>  PRT
<213>  Lokiarchaeum sp. GC14_75

<400>  35

Met Ile Met Lys Asp Phe His Ser Asp Ile Ser Gly Phe Tyr Lys Leu 
1               5                   10                  15      


Ser Ile Asp Glu Arg Gln Lys Leu Leu Ser Lys Leu Val Asn Leu Asn 
            20                  25                  30          


Pro Glu Asp Leu Glu Ile Leu Lys Glu Leu Gly Tyr Phe Thr Pro Thr 
        35                  40                  45              


Gln Ile Asp Thr Leu Ile Glu Asn Val Val Gly Ser Tyr Gln Leu Pro 
    50                  55                  60                  


Leu Gly Leu Ala Phe Asn Phe Arg Ile Asn Ser Lys Asp Tyr Ile Ile 
65                  70                  75                  80  


Pro Met Val Ile Glu Glu Pro Ser Val Val Ala Ala Ala Ser Asn Ala 
                85                  90                  95      


Ala Lys Met Ala Arg Lys His Gly Gly Phe His Ser Glu Asp Val Pro 
            100                 105                 110         


Pro Ile Met Ile Ser Gln Ile Gln Ile Thr Lys Leu Lys Asp Ile Glu 
        115                 120                 125             


Ala Ala Lys Asp Val Leu Glu Ala Lys Lys Gln Asp Leu Leu Lys Ile 
    130                 135                 140                 


Ala Asn Glu Gln Asp Pro Leu Leu Asn Lys Leu Gly Gly Gly Ala Gln 
145                 150                 155                 160 


Asn Ile Glu Ile His Glu Ile Gln Thr Asn Lys Gly Lys Met Ile Ile 
                165                 170                 175     


Leu His Leu Leu Val Asn Val Leu Asp Ala Met Gly Ala Asn Ile Val 
            180                 185                 190         


Asn Thr Met Ala Glu Ala Ile Ser Pro Tyr Ile Glu Glu Ile Cys Gly 
        195                 200                 205             


Gly Lys Ile Tyr Leu Arg Ile Val Ser Asn Leu Ala Thr His Arg Val 
    210                 215                 220                 


Ala Arg Ser Lys Ala Thr Phe Asp Lys Glu Met Leu Gly Gly Glu Glu 
225                 230                 235                 240 


Val Val Glu Gly Ile Met Asn Ala Tyr Glu Phe Ala Leu Ala Asp Pro 
                245                 250                 255     


Tyr Arg Ala Thr Thr His Asn Lys Gly Ile Met Asn Gly Val Val Ala 
            260                 265                 270         


Leu Thr Leu Ala Thr Gly Asn Asp Thr Arg Ala Ile Glu Ser Gly Ala 
        275                 280                 285             


His Ser Tyr Ala Ser Leu Ser Gly Arg Tyr Leu Pro Leu Thr Lys Phe 
    290                 295                 300                 


Asp Val Asp Ser Gln Gly Asn Leu Val Gly Glu Ile Glu Ile Pro Leu 
305                 310                 315                 320 


Ala Leu Gly Ile Ile Gly Gly Met Thr Lys Ile His Pro Met Ala Arg 
                325                 330                 335     


Leu Ala Leu Lys Ile Leu Asn Leu Lys Ser Ser Ser Glu Leu Ala Gln 
            340                 345                 350         


Val Gly Ala Ala Leu Gly Leu Ala Gln Asn Val Ala Ala Leu Arg Ala 
        355                 360                 365             


Leu Ala Ala Glu Gly Ile Gln Lys Gly His Met Ala Leu His Ser Arg 
    370                 375                 380                 


Asn Ile Ala Lys Val Ala Gly Val Pro Asp Glu Leu Ile Glu Lys Val 
385                 390                 395                 400 


Ser Lys Lys Met Val Ala Asp Lys Lys Ile Arg Val Asp Tyr Ala Lys 
                405                 410                 415     


Glu Ile Phe Gln Lys Ile Lys Asp Gly Glu Asn Ile 
            420                 425             


<210>  36
<211>  1284
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  36
atgatcatga aagacttcca ctccgatatt tccggtttct acaagctgtc catcgatgag       60

cgccagaagc ttttgagcaa gcttgtaaac ctgaacccgg aagatctgga aattcttaag      120

gaactgggct atttcacccc gactcaaatt gacaccctga tcgagaacgt tgtcggctcc      180

tatcaacttc ccttgggatt ggccttcaac tttcgcatca attctaagga ttacatcatc      240

cctatggtga tcgaagagcc atccgtggta gctgcagcat ccaatgcggc taagatggct      300

cgcaaacacg gcggttttca ctctgaagat gttcctccaa tcatgatctc acagattcaa      360

atcaccaaat tgaaagatat cgaggcagct aaagatgtcc tcgaggcgaa gaagcaggat      420

ttgctcaaga ttgccaacga acaagatccg ctgctgaaca aacttggcgg tggcgcccag      480

aacatcgaaa tccacgaaat ccaaactaac aagggcaaga tgatcatcct ccatctgctc      540

gtaaacgttc tcgatgccat gggtgccaac atcgtcaata ccatggcgga ggctatctct      600

ccatacatcg aagagatctg cggtggcaag atctaccttc gcattgtttc caacctggca      660

acccaccgtg tggcgcgttc caaggcaacc ttcgataagg aaatgctggg cggcgaagag      720

gtggtggaag gcatcatgaa tgcatatgaa ttcgcgctgg cggaccccta ccgcgctacc      780

acccataaca agggtatcat gaatggtgtt gtggctttga ctctggcgac gggtaatgac      840

acccgcgcaa tcgagagcgg agcccactct tacgcatccc tttccggccg ttacctgccc      900

ctgaccaagt ttgacgtaga ttctcaaggt aaccttgtgg gagaaatcga gattcctctt      960

gccctgggca ttatcggtgg tatgaccaag atccatccaa tggcccgtct ggctttgaag     1020

attcttaacc ttaaatcatc ttcagaactt gcacaggtag gtgcggcgct gggacttgcc     1080

caaaacgttg cagctctgcg cgcgctcgcc gctgaaggta tccagaaagg tcacatggca     1140

ctccactcac gtaatattgc aaaggtcgca ggcgtccctg acgaactgat tgaaaaagtg     1200

tctaaaaaga tggtcgccga taaaaagatt cgtgtggatt atgcaaagga aatcttccag     1260

aagatcaagg acggcgaaaa catt                                            1284


<210>  37
<211>  931
<212>  PRT
<213>  Cricetulus griseus

<400>  37

Met Thr Pro Asp Met Arg Lys Thr Gly Arg Cys Glu Ala Phe Leu Glu 
1               5                   10                  15      


Gln Arg Ser Ile Leu Leu Pro Asn Arg Phe Leu Phe Ser Gly His Pro 
            20                  25                  30          


His Ala Ala Thr Leu Thr Leu Pro Gln Glu Gly Pro Ser Gln Val Arg 
        35                  40                  45              


Phe Arg Gly Arg Gly Thr Pro Pro Ala Gly Ser Pro Ile Ala Arg Glu 
    50                  55                  60                  


Gly Gly Val Leu Ala Gly Ala Pro His Gly Ser Gly Thr Asn Lys Lys 
65                  70                  75                  80  


Val Val Met Leu Glu Leu Asp Gln Leu Leu Val Gly Ser Ala Val Val 
                85                  90                  95      


Arg Asp Gly Ala Val Pro Val Leu Arg Pro Gly Ser Arg Asp Arg Val 
            100                 105                 110         


Ala Thr Met Leu Ser Arg Leu Phe Arg Met His Gly Leu Phe Val Ala 
        115                 120                 125             


Ser His Pro Trp Glu Val Ile Val Gly Thr Val Thr Leu Thr Ile Cys 
    130                 135                 140                 


Met Met Ser Met Asn Met Phe Thr Gly Asn Asn Lys Ile Cys Gly Trp 
145                 150                 155                 160 


Asn Tyr Glu Cys Pro Lys Phe Glu Glu Asp Val Leu Ser Ser Asp Ile 
                165                 170                 175     


Ile Ile Leu Thr Ile Thr Arg Cys Ile Ala Ile Leu Tyr Ile Tyr Phe 
            180                 185                 190         


Gln Phe Gln Asn Leu Arg Gln Leu Gly Ser Lys Tyr Ile Leu Gly Ile 
        195                 200                 205             


Ala Gly Leu Phe Thr Ile Phe Ser Ser Phe Val Phe Ser Thr Val Val 
    210                 215                 220                 


Ile His Phe Leu Asp Lys Glu Leu Thr Gly Leu Asn Glu Ala Leu Pro 
225                 230                 235                 240 


Phe Phe Leu Leu Leu Ile Asp Leu Ser Arg Ala Ser Ala Leu Ala Lys 
                245                 250                 255     


Phe Ala Leu Ser Ser Asn Ser Gln Asp Glu Val Arg Glu Asn Ile Ala 
            260                 265                 270         


Arg Gly Met Ala Ile Leu Gly Pro Thr Phe Thr Leu Asp Ala Leu Val 
        275                 280                 285             


Glu Cys Leu Val Ile Gly Val Gly Thr Met Ser Gly Val Arg Gln Leu 
    290                 295                 300                 


Glu Ile Met Cys Cys Phe Gly Cys Met Ser Val Leu Ala Asn Tyr Phe 
305                 310                 315                 320 


Val Phe Met Thr Phe Phe Pro Ala Cys Val Ser Leu Val Leu Glu Leu 
                325                 330                 335     


Ser Arg Glu Ser Arg Glu Gly Arg Pro Ile Trp Gln Leu Ser His Phe 
            340                 345                 350         


Ala Arg Val Leu Glu Glu Glu Glu Asn Lys Pro Asn Pro Val Thr Gln 
        355                 360                 365             


Arg Val Lys Met Ile Met Ser Leu Gly Leu Val Leu Val His Ala His 
    370                 375                 380                 


Ser Arg Trp Ile Ala Asp Pro Ser Pro Gln Asn Ser Thr Thr Glu His 
385                 390                 395                 400 


Ser Lys Val Ser Leu Gly Leu Asp Glu Asp Val Ser Lys Arg Ile Glu 
                405                 410                 415     


Pro Ser Val Ser Leu Trp Gln Phe Tyr Leu Ser Lys Met Ile Ser Met 
            420                 425                 430         


Asp Ile Glu Gln Val Val Thr Leu Ser Leu Ala Phe Leu Leu Ala Val 
        435                 440                 445             


Lys Tyr Ile Phe Phe Glu Gln Ala Glu Thr Glu Ser Thr Leu Ser Leu 
    450                 455                 460                 


Lys Asn Pro Ile Thr Ser Pro Val Val Thr Pro Lys Lys Ala Pro Asp 
465                 470                 475                 480 


Asn Cys Cys Arg Arg Glu Pro Leu Leu Val Arg Arg Ser Glu Lys Leu 
                485                 490                 495     


Ser Ser Val Glu Glu Glu Pro Gly Val Ser Gln Asp Arg Lys Val Glu 
            500                 505                 510         


Val Ile Lys Pro Leu Val Val Glu Thr Glu Ser Ala Ser Arg Ala Thr 
        515                 520                 525             


Phe Val Leu Gly Ala Ser Gly Thr Ser Pro Pro Val Ala Ala Arg Thr 
    530                 535                 540                 


Gln Glu Leu Glu Ile Glu Leu Pro Ser Glu Pro Arg Pro Asn Glu Glu 
545                 550                 555                 560 


Cys Leu Gln Ile Leu Glu Ser Ala Glu Lys Gly Ala Lys Phe Leu Ser 
                565                 570                 575     


Asp Ala Glu Ile Ile Gln Leu Val Asn Ala Lys His Ile Pro Ala Tyr 
            580                 585                 590         


Lys Leu Glu Thr Leu Met Glu Thr His Glu Arg Gly Val Ser Ile Arg 
        595                 600                 605             


Arg Gln Leu Leu Ser Thr Lys Leu Pro Glu Pro Ser Ser Leu Gln Tyr 
    610                 615                 620                 


Leu Pro Tyr Arg Asp Tyr Asn Tyr Ser Leu Val Met Gly Ala Cys Cys 
625                 630                 635                 640 


Glu Asn Val Ile Gly Tyr Met Pro Ile Pro Val Gly Val Ala Gly Pro 
                645                 650                 655     


Leu Cys Leu Asp Gly Lys Glu Tyr Gln Val Pro Met Ala Thr Thr Glu 
            660                 665                 670         


Gly Cys Leu Val Ala Ser Thr Asn Arg Gly Cys Arg Ala Ile Gly Leu 
        675                 680                 685             


Gly Gly Gly Ala Ser Ser Arg Val Leu Ala Asp Gly Met Thr Arg Gly 
    690                 695                 700                 


Pro Val Val Arg Leu Pro Arg Ala Cys Asp Ser Ala Glu Val Lys Ala 
705                 710                 715                 720 


Trp Leu Glu Thr Pro Glu Gly Phe Ala Val Ile Lys Asp Ala Phe Asp 
                725                 730                 735     


Ser Thr Ser Arg Phe Ala Arg Leu Gln Lys Leu His Val Thr Met Ala 
            740                 745                 750         


Gly Arg Asn Leu Tyr Ile Arg Phe Gln Ser Lys Thr Gly Asp Ala Met 
        755                 760                 765             


Gly Met Asn Met Ile Ser Lys Gly Thr Glu Lys Ala Leu Leu Lys Leu 
    770                 775                 780                 


Gln Glu Phe Phe Pro Glu Met Gln Ile Leu Ala Val Ser Gly Asn Tyr 
785                 790                 795                 800 


Cys Thr Asp Lys Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly 
                805                 810                 815     


Lys Thr Val Val Cys Glu Ala Val Ile Pro Ala Lys Val Val Arg Glu 
            820                 825                 830         


Val Leu Lys Thr Thr Thr Glu Ala Met Ile Asp Val Asn Ile Asn Lys 
        835                 840                 845             


Asn Leu Val Gly Ser Ala Met Ala Gly Ser Ile Gly Gly Tyr Asn Ala 
    850                 855                 860                 


His Ala Ala Asn Ile Val Thr Ala Ile Tyr Ile Ala Cys Gly Gln Met 
865                 870                 875                 880 


Leu Gly Val Gln Gly Ala Cys Lys Asp Asn Pro Gly Glu Asn Ala Arg 
                885                 890                 895     


Gln Leu Ala Arg Ile Val Cys Gly Thr Val Met Ala Gly Glu Leu Ser 
            900                 905                 910         


Leu Met Ala Ala Leu Ala Ala Gly His Leu Val Arg Ser His Met Val 
        915                 920                 925             


His Asn Arg 
    930     


<210>  38
<211>  2793
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  38
atgacccctg acatgcgcaa gactggccgc tgcgaggcat tcctggagca acgctccatc       60

ttgctcccta atcgcttcct cttttcagga cacccacacg cagcaacctt gacacttcct      120

caggaaggcc caagccaggt ccgctttcgc ggacgaggca cgccgcccgc cggaagcccc      180

atcgcacgcg aaggcggtgt cctcgcaggt gctcctcacg gctctggcac taataaaaaa      240

gtcgtgatgt tggaattgga ccagttgctg gtgggctctg ccgtcgtgcg tgacggtgct      300

gtacctgtgt tgcgtcctgg ctcacgcgac cgcgtcgcca cgatgctgtc tcgcttgttc      360

cgcatgcatg gactttttgt ggcttctcac ccgtgggaag tgatcgtggg tacggtaaca      420

ctcaccatct gcatgatgtc catgaatatg ttcaccggta acaataaaat ttgtggctgg      480

aattatgagt gcccaaagtt cgaagaggac gtcttgtcct ctgatatcat cattttgacc      540

atcacccgtt gcatcgctat tctgtacatc tatttccagt tccaaaacct gcgtcaactg      600

ggttcaaagt acatccttgg tatcgcgggt cttttcacaa ttttttcgtc cttcgtgttc      660

agcactgtgg ttatccactt tttggacaag gaattgacag gacttaatga ggcgctccct      720

ttcttcctcc tgctgattga cctttcccga gcgtcagcat tggcgaaatt tgcattgtcg      780

tctaattctc aagatgaagt ccgagagaac atcgctcgcg gtatggcgat cctgggtccg      840

accttcacgc tcgatgctct ggtagagtgc cttgtcatcg gtgtaggcac catgagcgga      900

gtccgccagt tggagattat gtgttgcttt ggttgtatgt ctgtgctcgc caattacttc      960

gtattcatga cttttttccc tgcctgcgtg tctctcgtcc tcgaactctc ccgagagtcc     1020

cgcgagggcc gtccaatttg gcagctgtca cacttcgcac gagtcctcga ggaagaggaa     1080

aataagccaa acccagttac acagcgtgtt aagatgatca tgagcctggg cctggttctc     1140

gttcacgctc acagccgttg gatcgctgat ccgtctcccc aaaactccac gaccgaacac     1200

tccaaggttt ctcttggttt ggatgaagac gtttcaaagc gcatcgagcc ctccgtttcc     1260

ctctggcagt tttacctgtc caagatgatt tcgatggata tcgagcaggt cgtgaccctt     1320

agcttggcgt tccttttggc agttaagtac atcttcttcg agcaggcaga aacggagtct     1380

acattgtcac tcaagaaccc tatcacgtca ccagtggtga ccccaaaaaa agcacctgat     1440

aattgttgcc gccgtgaacc gctgcttgtt cgccgttccg agaagttgag cagcgtggaa     1500

gaggaaccgg gcgtctccca agaccgcaaa gttgaagtga ttaagccgct cgtcgtcgag     1560

acagaatccg cttcccgcgc tacttttgtc ttgggcgcat ctggaacatc ccctcctgtg     1620

gcggcacgta cacaggagtt ggagattgag ctgccatctg aaccacgtcc caacgaagag     1680

tgcttgcaga tcttggagtc cgccgaaaag ggcgccaagt tcctctctga cgccgaaatc     1740

atccagcttg tgaatgccaa acacattcca gcatacaaat tggaaacgct gatggaaact     1800

catgaacgcg gcgtctctat tcgccgacag cttcttagca ctaaactccc ggagccatcg     1860

tcgttgcagt atctcccata tcgagactac aactactcct tggtgatggg agcatgctgt     1920

gaaaacgtca tcggctacat gccgatccca gtaggcgtgg caggtccact ttgccttgat     1980

ggcaaggagt accaggtccc catggctacc acggagggct gccttgttgc atccacaaac     2040

cgtggctgtc gcgcgatcgg tcttggcgga ggagcatcat cgcgtgtact tgctgatggt     2100

atgacccgcg gccctgtagt tcgtctcccc cgcgcgtgcg atagcgctga ggttaaggcc     2160

tggttggaaa cacctgaggg atttgcagtg atcaaggacg cctttgactc tacctcacgc     2220

ttcgcgcgct tgcagaagct ccacgttacc atggcgggtc gcaacttgta tatccgcttc     2280

cagtccaaaa ccggagacgc tatgggaatg aatatgatct ccaaaggtac cgaaaaagct     2340

ctcctgaagc tccaggaatt cttcccagaa atgcaaattc tcgcggttag cggcaactat     2400

tgcaccgaca agaagccagc agccatcaac tggatcgagg gtcgaggtaa gaccgttgtc     2460

tgcgaggccg ttattccggc taaggtggtc cgtgaggtgc tgaagaccac gacggaagcg     2520

atgatcgatg tgaacatcaa caagaacctc gtcggctccg cgatggcggg ttccattggc     2580

ggttacaatg ctcacgctgc taatatcgta actgctattt atattgcttg cggtcagatg     2640

cttggcgttc aaggtgcatg caaggataac ccaggtgaga acgcccgtca gttggcacgt     2700

atcgtatgcg gcaccgtgat ggcaggcgaa ctttccctta tggccgcact ggcggctggt     2760

cacctcgtcc gttcacacat ggttcataac cgc                                  2793


<210>  39
<211>  428
<212>  PRT
<213>  Pyrodictium occultum

<400>  39

Met Gly Glu Glu Arg Ser Leu Arg Asp Arg Leu Glu Glu Val Val Gln 
1               5                   10                  15      


Gly Ile Val Glu Gly Arg Ile Arg Leu His Glu Ala Asp Arg Leu Leu 
            20                  25                  30          


Gly Asn Ala Asn Ala Ala Ala Leu Ala Arg Arg Leu Ala Leu Glu Arg 
        35                  40                  45              


Met Leu Gly Val Gly Leu Ser Ser Ile Gly Ser Thr Ile Leu Asp Phe 
    50                  55                  60                  


Glu Glu Leu Val Gly Arg Asn Ile Glu Asn Pro Ile Gly Ala Val Gln 
65                  70                  75                  80  


Ile Pro Leu Gly Val Ala Gly Pro Leu Arg Val His Gly Glu Tyr Ala 
                85                  90                  95      


Arg Gly Asp Phe Tyr Ile Pro Leu Ala Thr Thr Glu Gly Ala Leu Val 
            100                 105                 110         


Ala Ser Val Asn Arg Gly Ala Lys Ala Val Thr Leu Ser Gly Gly Ala 
        115                 120                 125             


Arg Ala Arg Val Leu Arg Asp Gly Met Ala Arg Ala Pro Val Phe Trp 
    130                 135                 140                 


Thr Pro Gly Val Glu Glu Ala Ala Arg Leu Ala Glu Trp Val Gln Glu 
145                 150                 155                 160 


His Met Glu Glu Val Arg Arg Glu Ala Glu Ser Thr Thr Arg His Gly 
                165                 170                 175     


Arg Leu Leu Glu Ile Gln Pro Phe Ile Ala Gly Asn Ile Val Trp Leu 
            180                 185                 190         


Arg Phe Val Tyr Ser Thr Gly Asp Ala Met Gly Met Asn Met Ala Thr 
        195                 200                 205             


Ile Ala Thr Asp Lys Ala Ala Glu Trp Ile Leu Arg Asn Tyr Pro Gly 
    210                 215                 220                 


Glu Ala Lys Leu Ile Ala Ile Ser Gly Asn Leu Cys Thr Asp Lys Lys 
225                 230                 235                 240 


Pro Ala Leu Leu Asn Ala Ile Leu Gly Arg Gly Lys Thr Val Val Ala 
                245                 250                 255     


Glu Ala Thr Ile Lys Arg Asp Ile Ala Leu Arg Val Leu Lys Ala Ala 
            260                 265                 270         


Pro Glu Asp Ile Asp Thr Val Asn Arg Val Lys Asn Leu Leu Gly Ser 
        275                 280                 285             


Ala Arg Ala Gly Ser Pro Ser Phe Asn Ala His Tyr Ala Asn Ile Ile 
    290                 295                 300                 


Ala Ala Ile Phe Ile Ala Thr Gly Gln Asp Val Ala Gln Val Val Glu 
305                 310                 315                 320 


Ser Ser Met Gly Tyr Thr Trp Thr Glu Val Arg Asn Gly Asp Leu Tyr 
                325                 330                 335     


Ile Ser Val Thr Leu Pro Ser Leu Glu Leu Gly Thr Val Gly Gly Gly 
            340                 345                 350         


Thr Arg Leu Pro Thr Gln Arg Glu Ala Leu Ala Leu Leu Gly Ala Ala 
        355                 360                 365             


Gly Gly Gly Asn Pro Pro Gly Ala Asn Ala Lys Lys Leu Ala Glu Val 
    370                 375                 380                 


Thr Ala Ala Ala Val Leu Ala Gly Glu Leu Asn Leu Leu Ala Ala Leu 
385                 390                 395                 400 


Ala Ala Asn Glu Leu Ala Arg Ala His Arg Leu Leu Gly Arg Gly Glu 
                405                 410                 415     


Ala Lys Thr Gly Asn Lys Asn Pro Thr Asn His Gly 
            420                 425             


<210>  40
<211>  1284
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  40
atgggagaag agcgctctct gcgcgatcgc ctggaagagg tagtccaagg catcgtagag       60

ggtcgcatcc gcctgcatga agcagaccgc ctgctgggaa atgcaaatgc agcagcgttg      120

gctcgccgcc tggcactgga acgcatgctt ggagttggct tgtccagcat tggatcgacg      180

attttggact tcgaagagct tgttggccgt aatattgaaa acccgatcgg tgccgtgcag      240

atccccctcg gtgtcgcggg cccgctgcgc gtccacggcg agtatgctcg cggtgacttc      300

tacattccac ttgctaccac tgaaggcgca cttgtggcat cagtgaatcg cggcgcaaag      360

gctgtgacgc tctctggcgg tgcacgcgcc cgcgtacttc gagatggcat ggcccgagca      420

ccggtgtttt ggactcctgg tgtggaagaa gcagcgcgac tcgcggaatg ggtgcaagag      480

catatggaag aagtccgtcg tgaagcagag tccacgacgc gtcacggacg tctcctcgaa      540

atccagccgt tcatcgctgg caacatcgtt tggcttcgct tcgtctattc taccggcgac      600

gccatgggca tgaacatggc aaccattgca accgataagg cggcagagtg gatcctgcgc      660

aattacccgg gagaagcgaa actcatcgca atctccggca acctctgcac agacaagaag      720

cctgctctct tgaacgctat tctgggccgc ggtaaaaccg tggtcgcgga ggcaactatt      780

aagcgcgaca tcgcattgcg cgtgcttaaa gcagctcccg aggacatcga tactgtgaac      840

cgtgtgaaaa atcttttggg cagcgctcgc gccggttcac cttcgtttaa cgcacactat      900

gctaacatca ttgcagcaat cttcatcgcg acaggacagg atgtggcgca ggtagtggag      960

tccagcatgg gatacacctg gaccgaagtt cgcaatggag acctttacat ttccgtgacg     1020

ctgccctcct tggaactggg caccgttggc ggtggtaccc gcctgcccac acagcgcgag     1080

gcactcgccc tcctgggagc agcaggcggt ggtaacccac cgggtgccaa tgcgaagaag     1140

ttggcagagg ttacagccgc agccgtgctg gccggcgaac tcaatttgtt ggccgctctt     1200

gcagcgaatg aactcgcccg cgcgcaccgt ttgctgggtc gtggcgaagc gaagactggt     1260

aataaaaatc caaccaacca cggt                                            1284


<210>  41
<211>  352
<212>  PRT
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  41

Met Ala Ser Glu Lys Glu Ile Arg Arg Glu Arg Phe Leu Asn Val Phe 
1               5                   10                  15      


Pro Lys Leu Val Glu Glu Leu Asn Ala Ser Leu Leu Ala Tyr Gly Met 
            20                  25                  30          


Pro Lys Glu Ala Cys Asp Trp Tyr Ala His Ser Leu Asn Tyr Asn Thr 
        35                  40                  45              


Pro Gly Gly Lys Leu Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Ala 
    50                  55                  60                  


Ile Leu Ser Asn Lys Thr Val Glu Gln Leu Gly Gln Glu Glu Tyr Glu 
65                  70                  75                  80  


Lys Val Ala Ile Leu Gly Trp Cys Ile Glu Leu Leu Gln Ala Tyr Phe 
                85                  90                  95      


Leu Val Ala Asp Asp Met Met Asp Lys Ser Ile Thr Arg Arg Gly Gln 
            100                 105                 110         


Pro Cys Trp Tyr Lys Val Pro Glu Val Gly Glu Ile Ala Ile Asn Asp 
        115                 120                 125             


Ala Phe Met Leu Glu Ala Ala Ile Tyr Lys Leu Leu Lys Ser His Phe 
    130                 135                 140                 


Arg Asn Glu Lys Tyr Tyr Ile Asp Ile Thr Glu Leu Phe His Glu Val 
145                 150                 155                 160 


Thr Phe Gln Thr Glu Leu Gly Gln Leu Met Asp Leu Ile Thr Ala Pro 
                165                 170                 175     


Glu Asp Lys Val Asp Leu Ser Lys Phe Ser Leu Lys Lys His Ser Phe 
            180                 185                 190         


Ile Val Thr Phe Gly Thr Ala Tyr Tyr Ser Phe Tyr Leu Pro Val Ala 
        195                 200                 205             


Leu Ala Met Tyr Val Ala Gly Ile Thr Asp Glu Lys Asp Leu Lys Gln 
    210                 215                 220                 


Ala Arg Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe Gln Ile Gln Asp 
225                 230                 235                 240 


Asp Tyr Leu Asp Cys Phe Gly Thr Pro Glu Gln Ile Gly Lys Ile Gly 
                245                 250                 255     


Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Val Ile Asn Lys Ala Leu 
            260                 265                 270         


Glu Leu Ala Ser Ala Glu Gln Arg Lys Thr Leu Asp Glu Asn Tyr Gly 
        275                 280                 285             


Lys Lys Asp Ser Val Ala Glu Ala Lys Cys Lys Lys Ile Phe Asn Asp 
    290                 295                 300                 


Leu Lys Ile Glu Gln Leu Tyr His Glu Tyr Glu Glu Ser Ile Ala Lys 
305                 310                 315                 320 


Asp Leu Lys Ala Lys Ile Ser Gln Val Asp Glu Ser Arg Gly Phe Lys 
                325                 330                 335     


Ala Asp Val Leu Thr Ala Phe Leu Asn Lys Val Tyr Lys Arg Ser Lys 
            340                 345                 350         


<210>  42
<211>  1056
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  42
atggcgtcgg aaaaagaaat ccgccgcgag cgcttcctga atgtgtttcc aaagctggtc       60

gaggaattga acgcttcgct gcttgcgtat ggcatgccga aagaggcgtg cgattggtac      120

gcacattccc tgaactataa caccccaggc ggtaaactca accgcggtct gtccgttgta      180

gatacatatg ccattcttag caacaagacc gtagaacagt tgggacaaga ggaatatgaa      240

aaggtggcta tcttgggctg gtgtatcgaa ctgttgcaag cctacttcct ggtcgccgat      300

gatatgatgg ataagtccat cacacgacgt ggacagccat gttggtacaa ggtccctgaa      360

gtcggcgaaa tcgctatcaa cgacgcattc atgctcgagg cagcaattta caaacttttg      420

aaaagccatt tccgaaacga gaagtattac atcgacatta ccgagctctt ccatgaagtc      480

accttccaga ccgaactcgg ccaattgatg gatctgatta ccgccccgga ggacaaggtc      540

gatctttcca aattcagcct gaagaaacat tccttcatcg taacctttgg tacagcatac      600

tattcattct atcttcctgt ggcactcgca atgtacgtag ccggtatcac ggatgaaaag      660

gatctgaaac aagcacgcga cgtactcatt cccctgggtg agtactttca gattcaagat      720

gactacctcg attgcttcgg cacgcctgaa caaatcggca aaatcggtac tgacatccag      780

gataataaat gctcctgggt gatcaataag gccctcgagt tggcgtcagc cgagcagcgc      840

aagactctgg acgaaaatta cggtaaaaaa gattcagttg ccgaggcaaa gtgcaaaaag      900

atctttaacg atcttaagat tgaacagctt taccacgaat acgaagaaag cattgctaag      960

gatctgaaag ctaagatttc tcaggtcgat gaatcacgcg gattcaaggc cgatgtgctc     1020

actgctttcc tgaacaaggt ctacaagcgc tcaaaa                               1056


<210>  43
<211>  296
<212>  PRT
<213>  Abies grandis

<400>  43

Met Phe Asp Phe Asn Lys Tyr Met Asp Ser Lys Ala Met Thr Val Asn 
1               5                   10                  15      


Glu Ala Leu Asn Lys Ala Ile Pro Leu Arg Tyr Pro Gln Lys Ile Tyr 
            20                  25                  30          


Glu Ser Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys Arg Val Arg Pro 
        35                  40                  45              


Val Leu Cys Ile Ala Ala Cys Glu Leu Val Gly Gly Thr Glu Glu Leu 
    50                  55                  60                  


Ala Ile Pro Thr Ala Cys Ala Ile Glu Met Ile His Thr Met Ser Leu 
65                  70                  75                  80  


Met His Asp Asp Leu Pro Cys Ile Asp Asn Asp Asp Leu Arg Arg Gly 
                85                  90                  95      


Lys Pro Thr Asn His Lys Ile Phe Gly Glu Asp Thr Ala Val Thr Ala 
            100                 105                 110         


Gly Asn Ala Leu His Ser Tyr Ala Phe Glu His Ile Ala Val Ser Thr 
        115                 120                 125             


Ser Lys Thr Val Gly Ala Asp Arg Ile Leu Arg Met Val Ser Glu Leu 
    130                 135                 140                 


Gly Arg Ala Thr Gly Ser Glu Gly Val Met Gly Gly Gln Met Val Asp 
145                 150                 155                 160 


Ile Ala Ser Glu Gly Asp Pro Ser Ile Asp Leu Gln Thr Leu Glu Trp 
                165                 170                 175     


Ile His Ile His Lys Thr Ala Met Leu Leu Glu Cys Ser Val Val Cys 
            180                 185                 190         


Gly Ala Ile Ile Gly Gly Ala Ser Glu Ile Val Ile Glu Arg Ala Arg 
        195                 200                 205             


Arg Tyr Ala Arg Cys Val Gly Leu Leu Phe Gln Val Val Asp Asp Ile 
    210                 215                 220                 


Leu Asp Val Thr Lys Ser Ser Asp Glu Leu Gly Lys Thr Ala Gly Lys 
225                 230                 235                 240 


Asp Leu Ile Ser Asp Lys Ala Thr Tyr Pro Lys Leu Met Gly Leu Glu 
                245                 250                 255     


Lys Ala Lys Glu Phe Ser Asp Glu Leu Leu Asn Arg Ala Lys Gly Glu 
            260                 265                 270         


Leu Ser Cys Phe Asp Pro Val Lys Ala Ala Pro Leu Leu Gly Leu Ala 
        275                 280                 285             


Asp Tyr Val Ala Phe Arg Gln Asn 
    290                 295     


<210>  44
<211>  888
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  44
atgttcgact tcaacaaata catggacagc aaggcaatga ccgtgaacga ggcgctgaat       60

aaagctattc ctttgcgtta tccgcagaag atctacgaat ccatgcgata ctctttgttg      120

gcaggtggta agcgagtgcg ccccgtgctt tgcattgcgg cttgcgagct ggtcggtggt      180

actgaggaac tggcgatccc aaccgcttgt gctatcgaga tgattcacac gatgtccctt      240

atgcacgatg acctgccctg tatcgacaac gatgatttgc gccgaggcaa gccaacaaat      300

cataagatct tcggcgagga caccgccgtc actgccggca atgctctgca ctcgtatgcc      360

ttcgagcaca ttgccgtgtc tacttccaaa acggtgggtg cagatcgcat tctgcgcatg      420

gtatccgagt tgggtcgcgc aactggctcg gagggcgtca tgggtggtca aatggtcgac      480

atcgcatctg aaggcgatcc atcgatcgac ctgcagacat tggaatggat ccacatccac      540

aagactgcga tgcttttgga atgttccgtg gtgtgcggag ctattattgg cggagcatct      600

gagatcgtga tcgagcgcgc tcgccgttat gctcgttgcg tgggtttgct gtttcaggtc      660

gtggacgaca ttctcgatgt caccaaatcc tccgatgagt tgggtaaaac tgccggcaaa      720

gacttgattt ctgacaaggc gacctacccc aagcttatgg gtctcgaaaa agccaaggag      780

ttctcagatg aactcctcaa ccgcgcaaag ggagaactct catgctttga tccagtgaag      840

gcagccccat tgcttggttt ggctgattac gtggccttcc gccagaat                   888


<210>  45
<211>  297
<212>  PRT
<213>  Picea abies

<400>  45

Met Glu Phe Asp Phe Asp Lys Tyr Met His Ser Lys Ala Ile Ala Val 
1               5                   10                  15      


Asn Glu Ala Leu Asp Lys Val Ile Pro Pro Arg Tyr Pro Gln Lys Ile 
            20                  25                  30          


Tyr Glu Ser Met Arg Tyr Ser Leu Leu Ala Gly Gly Lys Arg Val Arg 
        35                  40                  45              


Pro Ile Leu Cys Ile Ala Ala Cys Glu Leu Met Gly Gly Thr Glu Glu 
    50                  55                  60                  


Leu Ala Met Pro Thr Ala Cys Ala Ile Glu Met Ile His Thr Met Ser 
65                  70                  75                  80  


Leu Ile His Asp Asp Leu Pro Tyr Ile Asp Asn Asp Asp Leu Arg Arg 
                85                  90                  95      


Gly Lys Pro Thr Asn His Lys Val Phe Gly Glu Asp Thr Ala Ile Ile 
            100                 105                 110         


Ala Gly Asp Ala Leu Leu Ser Leu Ala Phe Glu His Val Ala Val Ser 
        115                 120                 125             


Thr Ser Arg Thr Leu Gly Thr Asp Ile Ile Leu Arg Leu Leu Ser Glu 
    130                 135                 140                 


Ile Gly Arg Ala Thr Gly Ser Glu Gly Val Met Gly Gly Gln Val Val 
145                 150                 155                 160 


Asp Ile Glu Ser Glu Gly Asp Pro Ser Ile Asp Leu Glu Thr Leu Glu 
                165                 170                 175     


Trp Val His Ile His Lys Thr Ala Val Leu Leu Glu Cys Ser Val Val 
            180                 185                 190         


Cys Gly Ala Ile Met Gly Gly Ala Ser Glu Asp Asp Ile Glu Arg Ala 
        195                 200                 205             


Arg Arg Tyr Ala Arg Cys Val Gly Leu Leu Phe Gln Val Val Asp Asp 
    210                 215                 220                 


Ile Leu Asp Val Ser Gln Ser Ser Glu Glu Leu Gly Lys Thr Ala Gly 
225                 230                 235                 240 


Lys Asp Leu Ile Ser Asp Lys Ala Thr Tyr Pro Lys Leu Met Gly Leu 
                245                 250                 255     


Glu Lys Ala Lys Glu Phe Ala Asp Glu Leu Leu Asn Arg Gly Lys Gln 
            260                 265                 270         


Glu Leu Ser Cys Phe Asp Pro Thr Lys Ala Ala Pro Leu Phe Ala Leu 
        275                 280                 285             


Ala Asp Tyr Ile Ala Ser Arg Gln Asn 
    290                 295         


<210>  46
<211>  891
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  46
atggaatttg atttcgataa gtacatgcac agcaaagcaa ttgccgtcaa cgaggctctc       60

gataaagtta tcccacctcg ttacccacag aaaatctacg aaagcatgcg ctattccctg      120

ctggcaggcg gcaaacgcgt acgcccaatc ctctgcatcg cggcctgcga acttatgggc      180

ggcaccgagg agctcgctat gccaaccgca tgcgcgattg agatgatcca caccatgagc      240

cttattcacg atgatctgcc atatatcgac aacgacgatt tgcgccgtgg aaagcctacc      300

aaccacaaag tcttcggaga ggacaccgcc atcattgctg gcgacgctct gctgtccctg      360

gcttttgagc acgttgcagt cagcacctcc cgcacgctcg gcacggatat tatcctgcgc      420

ctcctcagcg aaatcggtcg cgctaccggt tccgaaggtg tgatgggcgg tcaggtggtg      480

gatatcgaat ctgaaggcga tcccagcatc gaccttgaaa cgctggaatg ggtccatatc      540

cataagaccg cggttctgct ggaatgctct gttgtttgcg gtgcaatcat gggcggcgca      600

tcagaggatg acatcgagcg cgcacgtcgc tacgctcgtt gcgtaggctt gttgtttcaa      660

gtcgtggacg atatcctcga tgtatcccag tcttccgaag agctgggtaa gactgcgggc      720

aaggatctga tcagcgataa agccacctac ccaaaactta tgggtcttga gaaagcgaag      780

gaattcgctg acgaactgct gaaccgcggc aagcaggagc tgtcctgctt tgatccaacc      840

aaagccgcac cgctcttcgc tctggcagat tacattgcga gccgtcaaaa c               891


<210>  47
<211>  355
<212>  PRT
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  47

Met Thr Pro Asp Val Thr Asn Asp Ala Ser Gln Glu Thr Val Asp Leu 
1               5                   10                  15      


Val Arg Arg Thr Ser Ala Asp Leu Leu Arg Arg Val Glu Ala Arg Ile 
            20                  25                  30          


Gln Ser Leu Leu Ser Ala Gly His Asp Thr Trp Ala Ala Val Asp Glu 
        35                  40                  45              


Arg Ala Val Val Pro Ile Asp Ala Leu Ala Glu Leu Met Ala Ser Gly 
    50                  55                  60                  


Gly Lys Arg Ile Arg Pro Ala Phe Cys Ile Ala Gly His Leu Ala Ala 
65                  70                  75                  80  


Gly Gly Asp Pro Asp Asp Ser Gly Val Val Ala Ala Gly Ala Ala Leu 
                85                  90                  95      


Glu Met Leu His Ala Ser Leu Leu Val His Asp Asp Ile Leu Asp Asp 
            100                 105                 110         


Ser Ser Gln Arg Arg Gly Leu Pro Thr Val His Ala Lys His Thr Ala 
        115                 120                 125             


Leu His Gln Asp Leu Gly Trp Gln Gly Glu Ser Arg Arg Phe Gly Glu 
    130                 135                 140                 


Gly Val Gly Leu Leu Val Gly Gly Leu Ala Leu Thr Tyr Ala Asp Glu 
145                 150                 155                 160 


Leu Met Cys Glu Ala Pro Ala Thr Ala Ile Ala Glu Trp Asn Lys Leu 
                165                 170                 175     


Arg Ser Glu Val Leu Ile Gly Gln Tyr Met Asp Val Val Ala Ala Ala 
            180                 185                 190         


Glu Phe Ser Val Asp Pro Arg Leu Ser Arg Leu Ile Ala Val Ile Lys 
        195                 200                 205             


Ser Gly Arg Tyr Thr Ile His Arg Pro Leu Val Ile Gly Ala Asn Val 
    210                 215                 220                 


Ala Gly Arg Thr Asp Leu Asp Ala Ala Phe Ala Glu Tyr Gly Glu Ala 
225                 230                 235                 240 


Val Gly Glu Ala Phe Gln Leu Arg Asp Asp Leu Leu Asp Ala Phe Gly 
                245                 250                 255     


Asp Ser Ala Ala Thr Gly Lys Pro Ala Gly Leu Asp Phe Thr Gln His 
            260                 265                 270         


Lys Met Thr Leu Leu Leu Gly Trp Ala Met Gln Arg Asp Glu Ser Ile 
        275                 280                 285             


Arg Ala Leu Ile Thr Glu Pro Gly His Ser Ala Asp Asp Val Arg Arg 
    290                 295                 300                 


His Leu Leu Asp Thr Lys Val Pro Asp Asp Val Glu Gln His Ile Ala 
305                 310                 315                 320 


Gly Leu Val Glu Arg Gly Cys Lys Ala Ile Thr Asp Ala Pro Ile Ala 
                325                 330                 335     


Pro Val Trp Arg Glu Glu Leu Met Glu Met Ala Asn Arg Val Ala Tyr 
            340                 345                 350         


Arg Asp Ala 
        355 


<210>  48
<211>  1065
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  48
atgaccccag acgtgaccaa cgatgcctca caagaaaccg tcgatctggt tcgccgaacc       60

tctgcggatc tcctccgccg cgttgaagct cgcattcagt cccttctctc cgcgggccac      120

gatacctggg ctgccgtcga tgagcgagcc gttgttccaa ttgatgccct cgcagagctc      180

atggcttccg gtggaaaacg catccgcccg gcattctgca ttgccggcca cttggccgcc      240

ggtggagatc cagacgattc cggcgtcgtc gcggctggcg ccgcgctcga gatgcttcac      300

gcatcccttc tggtgcacga cgatatcctg gatgattcct ctcagcgccg cggcctccca      360

accgtccacg caaagcacac ggccctgcat caggatttgg gatggcaagg agagtcacgt      420

cgctttggag agggtgtggg actcttggtt ggtggccttg cacttaccta cgccgacgaa      480

ttgatgtgcg aagcgccagc aacagccatt gccgagtgga acaagctgcg atccgaagtg      540

cttatcggcc agtacatgga tgtggtcgca gctgcggagt ttagcgtgga cccacgcctt      600

tctcgcttga tcgctgtcat taaatcgggc cgctacacta ttcaccgtcc actggtcatt      660

ggtgctaacg tcgcgggccg caccgacttg gacgctgcgt tcgctgaata cggtgaagct      720

gtgggcgagg ctttccaact gcgcgatgac ctcctcgatg catttggtga tagcgccgca      780

accggtaagc cagcaggtct tgactttacc caacataaga tgaccctctt gttgggctgg      840

gcaatgcaac gcgacgagtc cattcgagcc ctcattaccg agcccggcca ctcggccgat      900

gacgttcgtc gccacctgct tgacaccaag gtgccagacg atgttgagca gcacattgcc      960

ggtttggtgg agcgaggatg caaagctatc acagacgcac caattgcgcc cgtgtggcgc     1020

gaagaactta tggaaatggc gaatcgcgtt gcatatcgcg atgct                     1065


<210>  49
<211>  415
<212>  PRT
<213>  Solanum lycopersicum

<400>  49

Met Ile Phe Ser Lys Gly Leu Ala Gln Ile Ser Arg Asn Arg Phe Ser 
1               5                   10                  15      


Arg Cys Arg Trp Leu Phe Ser Leu Arg Pro Ile Pro Gln Leu His Gln 
            20                  25                  30          


Ser Asn His Ile His Asp Pro Pro Lys Val Leu Gly Cys Arg Val Ile 
        35                  40                  45              


His Ser Trp Val Ser Asn Ala Leu Ser Gly Ile Gly Gln Gln Ile His 
    50                  55                  60                  


Gln Gln Ser Thr Ala Val Ala Glu Glu Gln Val Asp Pro Phe Ser Leu 
65                  70                  75                  80  


Val Ala Asp Glu Leu Ser Leu Leu Thr Asn Arg Leu Arg Ser Met Val 
                85                  90                  95      


Val Ala Glu Val Pro Lys Leu Ala Ser Ala Ala Glu Tyr Phe Phe Lys 
            100                 105                 110         


Leu Gly Val Glu Gly Lys Arg Phe Arg Pro Thr Val Leu Leu Leu Met 
        115                 120                 125             


Ala Thr Ala Leu Asn Val Gln Ile Pro Arg Ser Ala Pro Gln Val Asp 
    130                 135                 140                 


Val Asp Ser Phe Ser Gly Asp Leu Arg Thr Arg Gln Gln Cys Ile Ala 
145                 150                 155                 160 


Glu Ile Thr Glu Met Ile His Val Ala Ser Leu Leu His Asp Asp Val 
                165                 170                 175     


Leu Asp Asp Ala Asp Thr Arg Arg Gly Ile Gly Ser Leu Asn Phe Val 
            180                 185                 190         


Met Gly Asn Lys Leu Ala Val Leu Ala Gly Asp Phe Leu Leu Ser Arg 
        195                 200                 205             


Ala Cys Val Ala Leu Ala Ser Leu Lys Asn Thr Glu Val Val Cys Leu 
    210                 215                 220                 


Leu Ala Thr Val Val Glu His Leu Val Thr Gly Glu Thr Met Gln Met 
225                 230                 235                 240 


Thr Thr Ser Ser Asp Glu Arg Cys Ser Met Glu Tyr Tyr Met Gln Lys 
                245                 250                 255     


Thr Tyr Tyr Lys Thr Ala Ser Leu Ile Ser Asn Ser Cys Lys Ala Ile 
            260                 265                 270         


Ala Leu Leu Ala Gly His Ser Ala Glu Val Ser Val Leu Ala Phe Asp 
        275                 280                 285             


Tyr Gly Lys Asn Leu Gly Leu Ala Phe Gln Leu Ile Asp Asp Val Leu 
    290                 295                 300                 


Asp Phe Thr Gly Thr Ser Ala Thr Leu Gly Lys Gly Ser Leu Ser Asp 
305                 310                 315                 320 


Ile Arg His Gly Ile Val Thr Ala Pro Ile Leu Tyr Ala Met Glu Glu 
                325                 330                 335     


Phe Pro Gln Leu Arg Thr Leu Val Asp Arg Gly Phe Asp Asp Pro Val 
            340                 345                 350         


Asn Val Glu Ile Ala Leu Asp Tyr Leu Gly Lys Ser Arg Gly Ile Gln 
        355                 360                 365             


Arg Thr Arg Glu Leu Ala Arg Lys His Ala Ser Leu Ala Ser Ala Ala 
    370                 375                 380                 


Ile Asp Ser Leu Pro Glu Ser Asp Asp Glu Glu Val Gln Arg Ser Arg 
385                 390                 395                 400 


Arg Ala Leu Val Glu Leu Thr His Arg Val Ile Thr Arg Thr Lys 
                405                 410                 415 


<210>  50
<211>  1245
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  50
atgattttca gcaaaggatt ggcgcaaatt tctcgcaacc gtttttcacg ctgccgttgg       60

ctgttttcgc tgcgaccaat ccctcagctc caccagagca atcatattca tgatccaccc      120

aaggttcttg gttgccgagt aatccacagc tgggtttcca atgcgctgtc cggtatcggc      180

cagcagatcc accagcagtc taccgcagtg gcggaggaac aagtggatcc tttctccctc      240

gtggctgatg aactctccct cctgaccaat cgattgcgct ctatggtcgt cgccgaagtc      300

cccaaattgg cttccgcggc ggagtacttt ttcaagttgg gcgtggaggg aaaacgcttc      360

cgaccaaccg tcttgttgct catggctact gcgctgaatg tccagatccc ccgctccgca      420

ccgcaagttg atgtggatag cttctcaggc gatcttcgta cccgacagca gtgtatcgcc      480

gagattaccg agatgatcca cgttgcttca ttgctccatg atgacgtgct tgatgatgct      540

gatacccgtc gaggcatcgg ctcactgaat ttcgttatgg gcaataagct tgctgttctc      600

gctggtgatt ttttgctgtc ccgcgcgtgc gtggcattgg cctctctgaa aaacaccgag      660

gtggtttgcc ttcttgcaac agttgttgag catcttgtaa ccggtgagac catgcagatg      720

accacctcgt ccgatgaacg atgcagcatg gagtactaca tgcaaaagac ctactataaa      780

acggcgtccc tgatctcgaa ctcttgtaaa gctattgcgc tcctggctgg ccactctgcg      840

gaagtttcgg tgttggcatt tgattacggt aaaaatctcg gcttggcttt ccaattgatc      900

gatgatgttc ttgatttcac tggaacttcc gcaaccttgg gcaaaggttc cctgtccgat      960

attcgccacg gcatcgtcac cgccccaatc ttgtatgcga tggaagagtt ccctcagctc     1020

cgtaccctcg ttgatcgtgg cttcgatgat ccggtaaacg tggaaattgc cctcgactac     1080

ttgggtaagt ctcgcggcat ccaacgcaca cgcgagcttg cacgtaaaca cgcgtctctc     1140

gcgagcgcgg cgatcgactc cctgccggaa tccgatgatg aagaggtgca gcgcagccgc     1200

cgtgcgcttg ttgaattgac tcaccgcgtt atcacccgta ctaag                     1245


<210>  51
<211>  420
<212>  PRT
<213>  Catharanthus roseus

<400>  51

Met Leu Phe Ser Arg Gly Leu Tyr Arg Ile Ala Arg Thr Ser Leu Asn 
1               5                   10                  15      


Arg Ser Arg Leu Leu Tyr Pro Leu Gln Ser Gln Ser Pro Glu Leu Leu 
            20                  25                  30          


Gln Ser Phe Gln Phe Arg Ser Pro Ile Gly Ser Ser Gln Lys Val Ser 
        35                  40                  45              


Gly Phe Arg Val Ile Tyr Ser Trp Val Ser Ser Ala Leu Ala Asn Val 
    50                  55                  60                  


Gly Gln Gln Val Gln Arg Gln Ser Asn Ser Val Ala Glu Glu Pro Leu 
65                  70                  75                  80  


Asp Pro Phe Ser Leu Val Ala Asp Glu Leu Ser Ile Leu Ala Asn Arg 
                85                  90                  95      


Leu Arg Ser Met Val Val Ala Glu Val Pro Lys Leu Ala Ser Ala Ala 
            100                 105                 110         


Glu Tyr Phe Phe Lys Leu Gly Val Glu Gly Lys Arg Phe Arg Pro Thr 
        115                 120                 125             


Val Leu Leu Leu Met Ala Thr Ala Ile Asp Ala Pro Ile Ser Arg Thr 
    130                 135                 140                 


Pro Pro Asp Thr Ser Leu Asp Thr Leu Ser Thr Glu Leu Arg Leu Arg 
145                 150                 155                 160 


Gln Gln Thr Ile Ala Glu Ile Thr Lys Met Ile His Val Ala Ser Leu 
                165                 170                 175     


Leu His Asp Asp Val Leu Asp Asp Ala Glu Thr Arg Arg Gly Ile Gly 
            180                 185                 190         


Ser Leu Asn Phe Val Met Gly Asn Lys Leu Ala Val Leu Ala Gly Asp 
        195                 200                 205             


Phe Leu Leu Ser Arg Ala Cys Val Ala Leu Ala Ser Leu Lys Asn Thr 
    210                 215                 220                 


Glu Val Val Ser Leu Leu Ala Thr Val Val Glu His Leu Val Thr Gly 
225                 230                 235                 240 


Glu Thr Met Gln Met Thr Thr Thr Ser Asp Gln Arg Cys Ser Met Glu 
                245                 250                 255     


Tyr Tyr Met Gln Lys Thr Tyr Tyr Met Thr Ala Ser Leu Ile Ser Asn 
            260                 265                 270         


Ser Cys Lys Ala Ile Ala Leu Leu Ala Gly Gln Thr Ser Glu Val Ala 
        275                 280                 285             


Met Leu Ala Tyr Glu Tyr Gly Lys Asn Leu Gly Leu Ala Phe Gln Leu 
    290                 295                 300                 


Ile Asp Asp Val Leu Asp Phe Thr Gly Thr Ser Ala Ser Leu Gly Lys 
305                 310                 315                 320 


Gly Ser Leu Ser Asp Ile Arg His Gly Ile Val Thr Ala Pro Ile Leu 
                325                 330                 335     


Phe Ala Ile Glu Glu Phe Pro Glu Leu Arg Ala Val Val Asp Glu Gly 
            340                 345                 350         


Phe Glu Asn Pro Tyr Asn Val Asp Leu Ala Leu His Tyr Leu Gly Lys 
        355                 360                 365             


Ser Arg Gly Ile Gln Arg Thr Arg Glu Leu Ala Ile Lys His Ala Asn 
    370                 375                 380                 


Leu Ala Ser Asp Ala Ile Asp Ser Leu Pro Val Thr Asp Asp Glu His 
385                 390                 395                 400 


Val Leu Arg Ser Arg Arg Ala Leu Val Glu Leu Thr Gln Arg Val Ile 
                405                 410                 415     


Thr Arg Arg Lys 
            420 


<210>  52
<211>  1260
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  52
atgctgtttt cacgcggcct ctatcgcatc gcgcgaacct ccctgaaccg tagccgcctc       60

ttgtacccat tgcaatcaca aagccccgag ttgctccagt cgtttcagtt ccgctcgcct      120

attggatcat cccaaaaggt atccggattc cgtgttatct actcctgggt gtcctcggca      180

ttggccaacg tcggccagca ggtacaacga caaagcaact ccgtagcgga ggagcccctg      240

gatccatttt cactggttgc cgatgaactt tccattctcg ctaaccgtct ccgctcaatg      300

gtcgtcgctg aagtgcctaa gctcgcttcc gcagcagagt acttcttcaa gttgggtgtg      360

gagggcaagc gtttccgacc caccgtcctt ctgttgatgg cgaccgctat cgacgcaccc      420

atctctcgca caccacctga tacctcgttg gatacccttt ctactgagct tcgcctgcgc      480

caacagacca ttgccgagat caccaaaatg attcacgttg cttcgctcct ccacgatgat      540

gtgctcgatg acgctgagac ccgccgagga attggttcac ttaattttgt aatgggtaac      600

aagcttgctg tgctcgcagg tgatttcctg ctctcacgcg catgtgtggc cctggcttca      660

ctgaaaaata ccgaggtggt ttcgttgctg gccactgttg tagagcacct cgtcactggc      720

gagactatgc aaatgacaac cacgtcggac cagcgctgca gcatggagta ttatatgcag      780

aaaacttatt acatgaccgc gtctctgatt tcgaactcct gcaaggccat tgcgttgctc      840

gccggacaaa cctcggaggt cgccatgctt gcatatgaat acggtaaaaa cctgggattg      900

gccttccagc tcatcgacga tgtgctggat ttcactggaa caagcgctag cctgggtaag      960

ggttccttga gcgatatccg ccatggcatc gtaacggccc caattctctt cgcgattgaa     1020

gagttccctg agttgcgtgc tgtagttgat gaaggctttg agaacccata taacgtagac     1080

cttgctttgc attacctcgg taaatctcgt ggtattcaac gtacccgcga actggcgatt     1140

aaacacgcca atcttgcatc agatgcgatc gattctttgc cggttaccga tgacgaacac     1200

gtgctgcgct ctcgtcgcgc acttgtggaa cttacccagc gtgtgatcac gcgtcgcaaa     1260


<210>  53
<211>  367
<212>  PRT
<213>  C. glutamicum

<400>  53

Met Ser Thr Phe Asp Ala His Asp Leu Asp Leu Asp Thr Phe Pro Glu 
1               5                   10                  15      


Val Val Arg Asp Arg Leu Thr Gln Phe Leu Asp Ala Gln Ala Thr Thr 
            20                  25                  30          


Ile Ala Gly Ile Gly Asp Pro Val Thr Glu Ala Val Ser His Leu Arg 
        35                  40                  45              


Ser Phe Val Leu Asn Gly Gly Lys Arg Ile Arg Pro Leu Tyr Ala Trp 
    50                  55                  60                  


Ala Gly Phe Leu Ala Ala Gln Gly Leu Glu Asn Ser Gly Glu Lys Ile 
65                  70                  75                  80  


Glu Ala Val Leu Asp Ala Ala Ser Ser Leu Glu Phe Ile Gln Ala Tyr 
                85                  90                  95      


Phe Leu Ile His Asp Asp Pro Ala Ile Asp Ser Ser Asp Thr Arg Arg 
            100                 105                 110         


Gly Ala Pro Thr Val His Arg Ala Val Glu Ala Asn His Arg Ala His 
        115                 120                 125             


Asn Leu Glu Gly Asp Ser Glu His Phe Gly Glu Ser Val Ser Ile Leu 
    130                 135                 140                 


Ala Gly Asp Met Ala Leu Val Trp Ala Glu Asp Met Leu Gln Asp Ser 
145                 150                 155                 160 


Gly Leu Ser Ala Glu Ala Leu Ala Arg Thr Arg Asp Ala Trp Arg Gly 
                165                 170                 175     


Met Arg Thr Glu Val Ile Gly Gly Gln Leu Leu Asp Ile Tyr Leu Glu 
            180                 185                 190         


Ala His Ala Asn Glu Ala Val Glu Leu Ala Asp Ser Val Asn Arg Phe 
        195                 200                 205             


Lys Thr Ala Ala Tyr Thr Ile Ala Arg Pro Leu His Leu Gly Ala Ser 
    210                 215                 220                 


Ile Ala Gly Gly Ser Gln Glu Leu Ile Asp Ala Leu Leu His Tyr Gly 
225                 230                 235                 240 


His Asp Ile Gly Ile Ala Phe Gln Leu Arg Asp Asp Leu Leu Gly Val 
                245                 250                 255     


Phe Gly Asp Pro Lys Val Thr Gly Lys Pro Ala Gly Asp Asp Ile Arg 
            260                 265                 270         


Glu Gly Lys Arg Thr Val Leu Leu Ala Leu Ala Leu Gln Arg Ala Asp 
        275                 280                 285             


Lys Asn Ser Pro Glu Ala Ala Ala Ala Ile Arg Ala Gly Ile Gly Lys 
    290                 295                 300                 


Val Ser Thr Pro Glu Asp Ile Ala Val Ile Ala Lys His Ile Arg Ala 
305                 310                 315                 320 


Thr Gly Ala Glu Glu Glu Val Glu Gln Arg Ile Thr Gln Leu Thr Glu 
                325                 330                 335     


Ser Gly Leu Ala His Leu Asp Asp Val Glu Ile Pro Asp Glu Val Arg 
            340                 345                 350         


Thr Gln Leu Arg Ala Leu Ala Ile Arg Ser Thr Glu Arg Arg Met 
        355                 360                 365         


<210>  54
<211>  1101
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  54
atgtctacat tcgatgctca tgacttggac ctggatacct tccctgaagt tgtgcgcgac       60

cgcctgacgc agtttctcga tgcacaggca acgacgattg cgggtatcgg agaccccgtt      120

accgaggccg tatctcactt gcgttcgttt gtcctcaacg gaggtaagcg tatccgcccc      180

ctttatgcct gggccggctt tttggccgca caaggcctgg agaatagcgg cgaaaagatt      240

gaggcggtgt tggatgcagc gagcagcttg gaattcatcc aagcttattt tcttattcac      300

gatgacccag caattgattc ctccgacacc cgtcgcggcg cacctaccgt ccaccgcgct      360

gtggaagcca accaccgcgc gcacaacttg gagggagaca gcgaacactt cggtgagtcg      420

gtttccatcc ttgcaggtga tatggccctg gtttgggcag aggacatgct tcaggattct      480

ggcctttccg cagaagcgtt ggctcgtacc cgtgacgcct ggcgcggcat gcgcaccgag      540

gtcatcggtg gccagctgct ggacatctat ctggaagctc atgctaatga agccgtcgaa      600

ctggcagaca gcgtcaaccg ttttaagact gccgcatata ctattgcccg ccctcttcat      660

cttggtgcct caatcgctgg cggctcccag gaattgatcg atgcactgct ccactacgga      720

cacgatatcg gtatcgcatt ccagctccga gatgatctgc ttggtgtttt tggtgacccg      780

aaggtaacag gaaaaccagc cggcgatgac atccgtgaag gcaaacgcac agtgcttctc      840

gcattggcgt tgcagcgcgc agacaagaac agccctgagg cagctgccgc aatccgcgcg      900

ggcatcggca aggtgtccac cccggaagat attgctgtca tcgctaaaca tattcgtgcg      960

acaggcgcgg aagaagaagt agagcaacgc atcactcaac tgactgaatc aggcttggcg     1020

catttggatg atgtggaaat tcctgacgag gtgcgtaccc aactgcgcgc gctcgcaatc     1080

cgctccacgg agcgccgaat g                                               1101


<210>  55
<211>  296
<212>  PRT
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  55

Met Thr Asn Lys Leu Thr Ser Phe Leu Ala Asp Arg Lys Lys Thr Ile 
1               5                   10                  15      


Glu Asn Gln Leu Ser Val Tyr Thr Glu Lys Leu Asp Met Pro Asp Ser 
            20                  25                  30          


Leu Lys Lys Ser Met Leu Tyr Ser Leu Gln Ala Gly Gly Lys Arg Leu 
        35                  40                  45              


Arg Pro Leu Ile Val Leu Ala Val Leu Asn Ala Tyr Gly Lys Ser Glu 
    50                  55                  60                  


Lys Asp Gly Ile Pro Val Gly Cys Ala Val Glu Met Ile His Thr Tyr 
65                  70                  75                  80  


Phe Leu Ile His Asp Asp Leu Pro Cys Met Asp Asp Asp Asp Leu Arg 
                85                  90                  95      


Arg Gly Lys Pro Thr Asn His Lys Val Phe Gly Glu Ala Thr Ala Val 
            100                 105                 110         


Leu Ala Gly Asp Gly Leu Leu Thr Glu Ser Phe Lys Leu Ile Thr Ser 
        115                 120                 125             


His Val Ser Asp Glu Val Ser Ala Glu Lys Arg Leu Arg Leu Val Asn 
    130                 135                 140                 


Glu Leu Ile Ser Ala Ala Gly Thr Glu Gly Met Val Gly Gly Gln Val 
145                 150                 155                 160 


Ala Asp Met Glu Ala Glu Asn Arg Gln Val Thr Leu Glu Glu Leu Glu 
                165                 170                 175     


Ser Ile His Glu Arg Lys Thr Ala Lys Leu Leu Gly Phe Cys Val Ile 
            180                 185                 190         


Ala Gly Ala Ile Leu Ala Asp Ala Pro Glu Glu Asp Ile Glu Thr Leu 
        195                 200                 205             


Arg Thr Phe Ser Ser His Ile Gly Ile Gly Phe Gln Ile Arg Asp Asp 
    210                 215                 220                 


Ile Leu Asp Leu Glu Gly Ser Glu Glu Lys Ile Gly Lys Arg Val Gly 
225                 230                 235                 240 


Ser Asp Thr Thr Asn Asp Lys Ser Thr Tyr Pro Ser Leu Leu Ser Leu 
                245                 250                 255     


Glu Gly Ala Lys His Lys Leu Asp Val His Ile Lys Glu Ala Lys Arg 
            260                 265                 270         


Leu Ile Gly Gly Leu Ser Leu Gln Lys Asp Leu Leu Tyr Glu Leu Cys 
        275                 280                 285             


Asp Leu Ile Ala Ala Arg Asp His 
    290                 295     


<210>  56
<211>  888
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  56
atgactaata agctgacgtc cttcctcgca gaccgtaaaa agactatcga aaatcaattg       60

tctgtgtaca cagaaaagct cgatatgcct gattccctca agaagtctat gctttactcc      120

cttcaggcag gtggcaagcg tttgcgcccc ctcatcgtgc ttgcggttct caacgcctac      180

ggtaagtcag agaaagatgg tatcccggtt ggatgcgccg tggaaatgat ccacacctat      240

tttcttatcc acgacgatct tccgtgtatg gacgatgacg accttcgccg tggtaagcca      300

actaaccaca aggtttttgg tgaggcaact gcggttcttg caggtgatgg tctgcttacc      360

gaatccttta aacttatcac ttcccatgtt tctgatgaag tgtctgcaga aaaacgtctg      420

cgcctggtga acgaactcat cagcgccgcg ggcaccgaag gtatggtagg aggacaagtg      480

gctgatatgg aagccgagaa ccgtcaggtt acgcttgaag aactcgagtc tattcacgaa      540

cgcaagaccg ccaagctctt gggcttctgt gttattgctg gagccatcct tgcagatgca      600

cctgaagagg atattgaaac attgcgtacc ttttcatccc acatcggcat cggttttcag      660

atccgagacg acattcttga tctcgagggc tccgaagaaa agattggtaa acgcgtgggc      720

tccgacacca ccaatgacaa gtctacttac ccgtctcttc ttagccttga aggcgcaaag      780

cataagttgg acgttcatat taaggaggcg aagcgtttga ttggtggtct gagcctccag      840

aaagacttgc tctacgagct gtgcgatctc atcgcagcac gcgatcac                   888


<210>  57
<211>  396
<212>  PRT
<213>  S. cerevisiae S288c

<400>  57

Met Thr Val Tyr Thr Ala Ser Val Thr Ala Pro Val Asn Ile Ala Thr 
1               5                   10                  15      


Leu Lys Tyr Trp Gly Lys Arg Asp Thr Lys Leu Asn Leu Pro Thr Asn 
            20                  25                  30          


Ser Ser Ile Ser Val Thr Leu Ser Gln Asp Asp Leu Arg Thr Leu Thr 
        35                  40                  45              


Ser Ala Ala Thr Ala Pro Glu Phe Glu Arg Asp Thr Leu Trp Leu Asn 
    50                  55                  60                  


Gly Glu Pro His Ser Ile Asp Asn Glu Arg Thr Gln Asn Cys Leu Arg 
65                  70                  75                  80  


Asp Leu Arg Gln Leu Arg Lys Glu Met Glu Ser Lys Asp Ala Ser Leu 
                85                  90                  95      


Pro Thr Leu Ser Gln Trp Lys Leu His Ile Val Ser Glu Asn Asn Phe 
            100                 105                 110         


Pro Thr Ala Ala Gly Leu Ala Ser Ser Ala Ala Gly Phe Ala Ala Leu 
        115                 120                 125             


Val Ser Ala Ile Ala Lys Leu Tyr Gln Leu Pro Gln Ser Thr Ser Glu 
    130                 135                 140                 


Ile Ser Arg Ile Ala Arg Lys Gly Ser Gly Ser Ala Cys Arg Ser Leu 
145                 150                 155                 160 


Phe Gly Gly Tyr Val Ala Trp Glu Met Gly Lys Ala Glu Asp Gly His 
                165                 170                 175     


Asp Ser Met Ala Val Gln Ile Ala Asp Ser Ser Asp Trp Pro Gln Met 
            180                 185                 190         


Lys Ala Cys Val Leu Val Val Ser Asp Ile Lys Lys Asp Val Ser Ser 
        195                 200                 205             


Thr Gln Gly Met Gln Leu Thr Val Ala Thr Ser Glu Leu Phe Lys Glu 
    210                 215                 220                 


Arg Ile Glu His Val Val Pro Lys Arg Phe Glu Val Met Arg Lys Ala 
225                 230                 235                 240 


Ile Val Glu Lys Asp Phe Ala Thr Phe Ala Lys Glu Thr Met Met Asp 
                245                 250                 255     


Ser Asn Ser Phe His Ala Thr Cys Leu Asp Ser Phe Pro Pro Ile Phe 
            260                 265                 270         


Tyr Met Asn Asp Thr Ser Lys Arg Ile Ile Ser Trp Cys His Thr Ile 
        275                 280                 285             


Asn Gln Phe Tyr Gly Glu Thr Ile Val Ala Tyr Thr Phe Asp Ala Gly 
    290                 295                 300                 


Pro Asn Ala Val Leu Tyr Tyr Leu Ala Glu Asn Glu Ser Lys Leu Phe 
305                 310                 315                 320 


Ala Phe Ile Tyr Lys Leu Phe Gly Ser Val Pro Gly Trp Asp Lys Lys 
                325                 330                 335     


Phe Thr Thr Glu Gln Leu Glu Ala Phe Asn His Gln Phe Glu Ser Ser 
            340                 345                 350         


Asn Phe Thr Ala Arg Glu Leu Asp Leu Glu Leu Gln Lys Asp Val Ala 
        355                 360                 365             


Arg Val Ile Leu Thr Gln Val Gly Ser Gly Pro Gln Glu Thr Asn Glu 
    370                 375                 380                 


Ser Leu Ile Asp Ala Lys Thr Gly Leu Pro Lys Glu 
385                 390                 395     


<210>  58
<211>  1188
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  58
atgaccgttt acaccgcctc agtcaccgca ccagttaaca ttgcaaccct taaatactgg       60

ggcaagcgcg atactaagct taaccttcct accaactcat cgatctcggt gaccctgtct      120

caggatgatc tgcgaacgct tacttctgcg gcaacagcac cagaattcga gcgagatacg      180

ctctggctga atggcgaacc gcattccatt gacaacgagc gcacccagaa ctgcttgcgt      240

gatcttcgcc aactccgtaa ggagatggaa agcaaagatg caagcctccc aaccctctct      300

caatggaaac ttcacatcgt ctctgaaaac aacttcccta cggcggctgg cctggcgtcc      360

tcggcagctg gcttcgctgc attggtttcc gccattgcaa agctttatca gcttccgcaa      420

tcgacctccg agattagccg catcgcccgc aagggttcag gttcggcatg tcgctctctc      480

tttggaggct acgtggcctg ggaaatggga aaggccgaag atggtcacga ttccatggcg      540

gtgcaaatcg ccgatagctc agattggcct caaatgaagg cctgtgtgtt ggtggtatcc      600

gacatcaaaa aagacgtttc ctcgactcaa ggaatgcaac ttacggtagc tacgagcgaa      660

ctgtttaagg agcgcattga gcatgtggtg cccaaacgct ttgaagtcat gcgtaaggca      720

atcgtggaga aggacttcgc gaccttcgcg aaggaaacta tgatggatag caacagcttc      780

cacgctacgt gtctggattc gttccctccg attttctata tgaatgacac gtctaaacgc      840

atcatttcct ggtgtcacac gatcaaccaa ttctacggcg aaactatcgt agcatacact      900

tttgacgcag gaccgaacgc cgttctctac tacctcgccg aaaacgagtc aaaattgttc      960

gccttcatct acaaactctt tggatccgtc cctggttggg acaagaagtt cacgactgaa     1020

cagttggaag cattcaacca tcagtttgaa agctctaact tcacagcccg tgagctggac     1080

ctcgaactgc agaaagatgt ggcacgcgtc attcttaccc aagtgggctc cggaccccaa     1140

gagacgaatg agtctctgat tgacgccaaa acgggtctcc ccaaagaa                  1188


<210>  59
<211>  650
<212>  PRT
<213>  Yarrowia lipolytica CLIB 122 / E 150

<400>  59

Met Ser Ala Asn Glu Asn Ile Ser Arg Phe Asp Ala Pro Val Gly Lys 
1               5                   10                  15      


Glu His Pro Ala Tyr Glu Leu Phe His Asn His Thr Arg Ser Phe Val 
            20                  25                  30          


Tyr Gly Leu Gln Pro Arg Ala Cys Gln Gly Met Leu Asp Phe Asp Phe 
        35                  40                  45              


Ile Cys Lys Arg Glu Asn Pro Ser Val Ala Gly Val Ile Tyr Pro Phe 
    50                  55                  60                  


Gly Gly Gln Phe Val Thr Lys Met Tyr Trp Gly Thr Lys Glu Thr Leu 
65                  70                  75                  80  


Leu Pro Val Tyr Gln Gln Val Glu Lys Ala Ala Ala Lys His Pro Glu 
                85                  90                  95      


Val Asp Val Val Val Asn Phe Ala Ser Ser Arg Ser Val Tyr Ser Ser 
            100                 105                 110         


Thr Met Glu Leu Leu Glu Tyr Pro Gln Phe Arg Thr Ile Ala Ile Ile 
        115                 120                 125             


Ala Glu Gly Val Pro Glu Arg Arg Ala Arg Glu Ile Leu His Lys Ala 
    130                 135                 140                 


Gln Lys Lys Gly Val Thr Ile Ile Gly Pro Ala Thr Val Gly Gly Ile 
145                 150                 155                 160 


Lys Pro Gly Cys Phe Lys Val Gly Asn Thr Gly Gly Met Met Asp Asn 
                165                 170                 175     


Ile Val Ala Ser Lys Leu Tyr Arg Pro Gly Ser Val Ala Tyr Val Ser 
            180                 185                 190         


Lys Ser Gly Gly Met Ser Asn Glu Leu Asn Asn Ile Ile Ser His Thr 
        195                 200                 205             


Thr Asp Gly Val Tyr Glu Gly Ile Ala Ile Gly Gly Asp Arg Tyr Pro 
    210                 215                 220                 


Gly Thr Thr Phe Ile Asp His Ile Leu Arg Tyr Glu Ala Asp Pro Lys 
225                 230                 235                 240 


Cys Lys Ile Ile Val Leu Leu Gly Glu Val Gly Gly Val Glu Glu Tyr 
                245                 250                 255     


Arg Val Ile Glu Ala Val Lys Asn Gly Gln Ile Lys Lys Pro Ile Val 
            260                 265                 270         


Ala Trp Ala Ile Gly Thr Cys Ala Ser Met Phe Lys Thr Glu Val Gln 
        275                 280                 285             


Phe Gly His Ala Gly Ser Met Ala Asn Ser Asp Leu Glu Thr Ala Lys 
    290                 295                 300                 


Ala Lys Asn Ala Ala Met Lys Ser Ala Gly Phe Tyr Val Pro Asp Thr 
305                 310                 315                 320 


Phe Glu Asp Met Pro Glu Val Leu Ala Glu Leu Tyr Glu Lys Met Val 
                325                 330                 335     


Ala Lys Gly Glu Leu Ser Arg Ile Ser Glu Pro Glu Val Pro Lys Ile 
            340                 345                 350         


Pro Ile Asp Tyr Ser Trp Ala Gln Glu Leu Gly Leu Ile Arg Lys Pro 
        355                 360                 365             


Ala Ala Phe Ile Ser Thr Ile Ser Asp Asp Arg Gly Gln Glu Leu Leu 
    370                 375                 380                 


Tyr Ala Gly Met Pro Ile Ser Glu Val Phe Lys Glu Asp Ile Gly Ile 
385                 390                 395                 400 


Gly Gly Val Met Ser Leu Leu Trp Phe Arg Arg Arg Leu Pro Asp Tyr 
                405                 410                 415     


Ala Ser Lys Phe Leu Glu Met Val Leu Met Leu Thr Ala Asp His Gly 
            420                 425                 430         


Pro Ala Val Ser Gly Ala Met Asn Thr Ile Ile Thr Thr Arg Ala Gly 
        435                 440                 445             


Lys Asp Leu Ile Ser Ser Leu Val Ala Gly Leu Leu Thr Ile Gly Thr 
    450                 455                 460                 


Arg Phe Gly Gly Ala Leu Asp Gly Ala Ala Thr Glu Phe Thr Thr Ala 
465                 470                 475                 480 


Tyr Asp Lys Gly Leu Ser Pro Arg Gln Phe Val Asp Thr Met Arg Lys 
                485                 490                 495     


Gln Asn Lys Leu Ile Pro Gly Ile Gly His Arg Val Lys Ser Arg Asn 
            500                 505                 510         


Asn Pro Asp Phe Arg Val Glu Leu Val Lys Asp Phe Val Lys Lys Asn 
        515                 520                 525             


Phe Pro Ser Thr Gln Leu Leu Asp Tyr Ala Leu Ala Val Glu Glu Val 
    530                 535                 540                 


Thr Thr Ser Lys Lys Asp Asn Leu Ile Leu Asn Val Asp Gly Ala Ile 
545                 550                 555                 560 


Ala Val Ser Phe Val Asp Leu Met Arg Ser Cys Gly Ala Phe Thr Val 
                565                 570                 575     


Glu Glu Thr Glu Asp Tyr Leu Lys Asn Gly Val Leu Asn Gly Leu Phe 
            580                 585                 590         


Val Leu Gly Arg Ser Ile Gly Leu Ile Ala His His Leu Asp Gln Lys 
        595                 600                 605             


Arg Leu Lys Thr Gly Leu Tyr Arg His Pro Trp Asp Asp Ile Thr Tyr 
    610                 615                 620                 


Leu Val Gly Gln Glu Ala Ile Gln Lys Lys Arg Val Glu Ile Ser Ala 
625                 630                 635                 640 


Gly Asp Val Ser Lys Ala Lys Thr Arg Ser 
                645                 650 


<210>  60
<211>  1950
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  60
atgtctgcaa atgaaaacat ttcccgcttt gatgcacctg tgggtaagga gcatccagcc       60

tatgagctgt tccataacca cacccgctcc ttcgtctacg gtctccagcc tcgcgcgtgc      120

cagggtatgc tcgactttga tttcatttgt aagcgcgaga acccctcggt tgccggtgtt      180

atctaccctt tcggcggtca gttcgtgact aagatgtact ggggtaccaa ggagaccctg      240

ctcccggtgt accagcaagt tgaaaaagca gcagcgaaac atcccgaagt cgacgtcgtc      300

gtgaacttcg cgtcgtcccg cagcgtctac agctccacaa tggaactttt ggaataccca      360

caattccgca ccatcgctat catcgcagag ggcgtcccag aacgccgtgc gcgcgaaatc      420

ctgcacaagg ctcagaaaaa gggcgtgacg attatcggac cggcaaccgt cggcggcatt      480

aagcccggtt gctttaaagt tggtaatacg ggtggcatga tggacaacat cgtggcgtcc      540

aagctgtacc gcccaggttc cgttgcttac gtctccaagt ccggtggtat gtcaaatgag      600

cttaataaca tcatttccca cacgaccgat ggcgtgtacg agggaatcgc aattggtggc      660

gaccgctacc cgggcacaac ttttattgat cacatcttgc gttacgaagc ggatccaaag      720

tgcaagatca ttgtgctctt gggcgaagta ggtggcgtgg aagagtaccg cgttatcgag      780

gcggttaaaa acggtcaaat taagaagcca atcgtagcgt gggcaatcgg cacctgcgcc      840

tccatgttta agacggaagt acagtttggc catgctggct caatggctaa ctcagacctc      900

gagacggcta aagcaaaaaa tgcggcaatg aaatcagcag gcttttacgt gccggatacc      960

ttcgaggata tgcccgaagt cttggccgag ctctacgaga agatggtggc gaaaggcgag     1020

ctcagccgca tctccgaacc ggaggttcct aagatcccga tcgactatag ctgggcgcag     1080

gaacttggtt tgatccgcaa gccagccgca ttcatctcta ccatctcaga cgaccgcggc     1140

caagagctcc tttacgcggg catgcccatc tcagaggtct tcaaggagga catcggcatc     1200

ggtggcgtta tgtccctgct gtggtttcgt cgccgtctgc ctgattatgc atcgaaattc     1260

cttgaaatgg tgcttatgct gacggccgac cacggacctg ccgtttccgg tgcgatgaat     1320

acgatcatca ccactcgagc gggtaaggac ctcatttcct cccttgttgc cggccttctt     1380

acaattggta cccgcttcgg cggagcattg gacggcgcgg ccacagagtt tactaccgcc     1440

tacgataagg gcttgtcgcc ccgccaattt gtcgatacaa tgcgcaagca aaacaagctc     1500

atcccaggca tcggccaccg agtgaagtcc cgtaataacc ccgatttccg tgtggaactg     1560

gttaaggact ttgtgaagaa gaatttcccg tccacccagc tgttggatta cgcgctcgcc     1620

gttgaggagg tgaccacatc taaaaaggat aacttgatcc tcaacgttga tggtgcgatt     1680

gcggtttcgt tcgtcgatct tatgcgctcg tgtggtgctt ttaccgttga agaaacagaa     1740

gattatctga aaaatggcgt tttgaacggt ttgtttgtcc tcggtcgttc cattggcctg     1800

attgcgcacc acctggacca gaaacgtctt aaaaccggtc tttaccgcca tccttgggat     1860

gacattacgt acctcgttgg ccaagaggca attcagaaga agcgtgtgga gatctctgca     1920

ggcgacgttt caaaggcgaa gactcgaagc                                      1950


<210>  61
<211>  652
<212>  PRT
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  61

Met Ser Gln Thr His Lys His Ala Ile Pro Ala Asn Ile Ala Asp Arg 
1               5                   10                  15      


Cys Leu Ile Asn Pro Glu Gln Tyr Glu Thr Lys Tyr Lys Gln Ser Ile 
            20                  25                  30          


Asn Asp Pro Asp Thr Phe Trp Gly Glu Gln Gly Lys Ile Leu Asp Trp 
        35                  40                  45              


Ile Thr Pro Tyr Gln Lys Val Lys Asn Thr Ser Phe Ala Pro Gly Asn 
    50                  55                  60                  


Val Ser Ile Lys Trp Tyr Glu Asp Gly Thr Leu Asn Leu Ala Ala Asn 
65                  70                  75                  80  


Cys Leu Asp Arg His Leu Gln Glu Asn Gly Asp Arg Thr Ala Ile Ile 
                85                  90                  95      


Trp Glu Gly Asp Asp Thr Ser Gln Ser Lys His Ile Ser Tyr Arg Glu 
            100                 105                 110         


Leu His Arg Asp Val Cys Arg Phe Ala Asn Thr Leu Leu Asp Leu Gly 
        115                 120                 125             


Ile Lys Lys Gly Asp Val Val Ala Ile Tyr Met Pro Met Val Pro Glu 
    130                 135                 140                 


Ala Ala Val Ala Met Leu Ala Cys Ala Arg Ile Gly Ala Val His Ser 
145                 150                 155                 160 


Val Ile Phe Gly Gly Phe Ser Pro Glu Ala Val Ala Gly Arg Ile Ile 
                165                 170                 175     


Asp Ser Ser Ser Arg Leu Val Ile Thr Ala Asp Glu Gly Val Arg Ala 
            180                 185                 190         


Gly Arg Ser Ile Pro Leu Lys Lys Asn Val Asp Asp Ala Leu Lys Asn 
        195                 200                 205             


Pro Asn Val Thr Ser Val Glu His Val Ile Val Leu Lys Arg Thr Gly 
    210                 215                 220                 


Ser Asp Ile Asp Trp Gln Glu Gly Arg Asp Leu Trp Trp Arg Asp Leu 
225                 230                 235                 240 


Ile Glu Lys Ala Ser Pro Glu His Gln Pro Glu Ala Met Asn Ala Glu 
                245                 250                 255     


Asp Pro Leu Phe Ile Leu Tyr Thr Ser Gly Ser Thr Gly Lys Pro Lys 
            260                 265                 270         


Gly Val Leu His Thr Thr Gly Gly Tyr Leu Val Tyr Ala Ala Thr Thr 
        275                 280                 285             


Phe Lys Tyr Val Phe Asp Tyr His Pro Gly Asp Ile Tyr Trp Cys Thr 
    290                 295                 300                 


Ala Asp Val Gly Trp Val Thr Gly His Ser Tyr Leu Leu Tyr Gly Pro 
305                 310                 315                 320 


Leu Ala Cys Gly Ala Thr Thr Leu Met Phe Glu Gly Val Pro Asn Trp 
                325                 330                 335     


Pro Thr Pro Ala Arg Met Cys Gln Val Val Asp Lys His Gln Val Asn 
            340                 345                 350         


Ile Leu Tyr Thr Ala Pro Thr Ala Ile Arg Ala Leu Met Ala Glu Gly 
        355                 360                 365             


Asp Lys Ala Ile Glu Gly Thr Asp Arg Ser Ser Leu Arg Ile Leu Gly 
    370                 375                 380                 


Ser Val Gly Glu Pro Ile Asn Pro Glu Ala Trp Glu Trp Tyr Trp Lys 
385                 390                 395                 400 


Lys Ile Gly Lys Glu Lys Cys Pro Val Val Asp Thr Trp Trp Gln Thr 
                405                 410                 415     


Glu Thr Gly Gly Phe Met Ile Thr Pro Leu Pro Gly Ala Ile Glu Leu 
            420                 425                 430         


Lys Ala Gly Ser Ala Thr Arg Pro Phe Phe Gly Val Gln Pro Ala Leu 
        435                 440                 445             


Val Asp Asn Glu Gly His Pro Gln Glu Gly Ala Thr Glu Gly Asn Leu 
    450                 455                 460                 


Val Ile Thr Asp Ser Trp Pro Gly Gln Ala Arg Thr Leu Phe Gly Asp 
465                 470                 475                 480 


His Glu Arg Phe Glu Gln Thr Tyr Phe Ser Thr Phe Lys Asn Met Tyr 
                485                 490                 495     


Phe Ser Gly Asp Gly Ala Arg Arg Asp Glu Asp Gly Tyr Tyr Trp Ile 
            500                 505                 510         


Thr Gly Arg Val Asp Asp Val Leu Asn Val Ser Gly His Arg Leu Gly 
        515                 520                 525             


Thr Ala Glu Ile Glu Ser Ala Leu Val Ala His Pro Lys Ile Ala Glu 
    530                 535                 540                 


Ala Ala Val Val Gly Ile Pro His Ala Ile Lys Gly Gln Ala Ile Tyr 
545                 550                 555                 560 


Ala Tyr Val Thr Leu Asn His Gly Glu Glu Pro Ser Pro Glu Leu Tyr 
                565                 570                 575     


Ala Glu Val Arg Asn Trp Val Arg Lys Glu Ile Gly Pro Leu Ala Thr 
            580                 585                 590         


Pro Asp Val Leu His Trp Thr Asp Ser Leu Pro Lys Thr Arg Ser Gly 
        595                 600                 605             


Lys Ile Met Arg Arg Ile Leu Arg Lys Ile Ala Ala Gly Asp Thr Ser 
    610                 615                 620                 


Asn Leu Gly Asp Thr Ser Thr Leu Ala Asp Pro Gly Val Val Glu Lys 
625                 630                 635                 640 


Pro Leu Glu Glu Lys Gln Ala Ile Ala Met Pro Ser 
                645                 650         


<210>  62
<211>  1956
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  62
atgtctcaga ctcacaaaca cgctatccct gctaacattg ccgaccgctg tcttattaac       60

cctgagcaat atgaaactaa atacaagcaa tcgattaacg acccagatac cttttgggga      120

gagcagggca aaatcctcga ctggatcacc ccataccaaa aggtaaaaaa cacctcattt      180

gccccaggta acgtgtccat caagtggtac gaagatggta ctttgaacct ggcggccaac      240

tgccttgacc gacacctgca agagaacggt gaccgcaccg caatcatctg ggagggcgac      300

gacacctcac aatccaaaca catctcatat cgtgaacttc atcgcgacgt ttgccgtttc      360

gcaaacacgt tgctcgatct gggcatcaag aagggtgatg ttgtggcaat ctacatgccg      420

atggttccag aagcagcagt cgcgatgctt gcatgcgcac gcatcggcgc ggttcactca      480

gtgatcttcg gcggattttc ccccgaagcc gttgctggcc gtattatcga tagctcttcc      540

cgcctggtga tcactgctga cgagggtgtg cgcgcaggtc gttccattcc gttgaagaag      600

aacgtcgatg atgccttgaa gaatcccaat gtgacctccg tggaacacgt tatcgtgttg      660

aaacgcactg gctcagacat cgactggcag gaaggccgag atttgtggtg gcgagacctc      720

atcgaaaagg cgtccccgga acatcaacct gaggcaatga acgcggaaga tccgttgttt      780

attttgtaca cctcgggaag cacgggtaag ccaaaaggtg tgctccatac caccggcggt      840

tatctcgtgt acgcagcgac tactttcaaa tatgttttcg actatcaccc cggagatatc      900

tactggtgca cagcagacgt tggttgggtt accggacatt cctacctgct gtacggtcct      960

ctggcatgcg gcgcaactac gttgatgttt gaaggtgtgc ctaactggcc tactccagcg     1020

cgcatgtgtc aagtcgtgga caagcaccag gtaaacatcc tctatacagc acctaccgcc     1080

atccgagccc tcatggctga aggcgataag gccattgagg gtacagatcg ttcctccttg     1140

cgtatcctcg gctcagtggg cgaaccaatc aaccctgaag catgggaatg gtactggaag     1200

aagattggaa aggagaagtg tccagttgtg gatacctggt ggcagacaga gactggtggt     1260

ttcatgatta cccctctccc gggagcgatt gagttgaaag ccggttccgc gacccgccca     1320

ttcttcggag tacagccagc gcttgtggac aacgaaggac acccacagga aggcgccacc     1380

gaaggcaacc tggtcatcac ggacagctgg ccaggtcagg cacgtaccct gttcggcgac     1440

catgagcgct tcgagcaaac gtacttctct accttcaaga acatgtattt ctccggtgac     1500

ggtgcccgtc gcgatgaaga tggctactac tggattacag gccgcgttga tgacgttctc     1560

aacgttagcg gacaccgttt gggtaccgca gaaatcgaat ccgctctggt agcacacccg     1620

aaaatcgctg aagcagccgt ggtgggtatc ccgcacgcga tcaagggtca agctatctac     1680

gcatacgtca cgcttaatca cggagaagaa ccatcgcccg agttgtacgc cgaggtgcgc     1740

aattgggtcc gaaaagaaat tggcccactg gcaacccccg atgtgctcca ttggactgat     1800

agcctgccca agactcgttc tggtaaaatt atgcgccgca tcctgcgcaa gattgcagct     1860

ggagacacct ccaatttggg cgatacctcc actttggccg atccaggagt ggtggagaaa     1920

ccgctcgaag aaaaacaggc aatcgctatg ccttcc                               1956


<210>  63
<211>  500
<212>  PRT
<213>  S. cerevisiae S288c

<400>  63

Met Thr Lys Leu His Phe Asp Thr Ala Glu Pro Val Lys Ile Thr Leu 
1               5                   10                  15      


Pro Asn Gly Leu Thr Tyr Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn 
            20                  25                  30          


Lys Phe Met Lys Ala Gln Asp Gly Lys Thr Tyr Pro Val Glu Asp Pro 
        35                  40                  45              


Ser Thr Glu Asn Thr Val Cys Glu Val Ser Ser Ala Thr Thr Glu Asp 
    50                  55                  60                  


Val Glu Tyr Ala Ile Glu Cys Ala Asp Arg Ala Phe His Asp Thr Glu 
65                  70                  75                  80  


Trp Ala Thr Gln Asp Pro Arg Glu Arg Gly Arg Leu Leu Ser Lys Leu 
                85                  90                  95      


Ala Asp Glu Leu Glu Ser Gln Ile Asp Leu Val Ser Ser Ile Glu Ala 
            100                 105                 110         


Leu Asp Asn Gly Lys Thr Leu Ala Leu Ala Arg Gly Asp Val Thr Ile 
        115                 120                 125             


Ala Ile Asn Cys Leu Arg Asp Ala Ala Ala Tyr Ala Asp Lys Val Asn 
    130                 135                 140                 


Gly Arg Thr Ile Asn Thr Gly Asp Gly Tyr Met Asn Phe Thr Thr Leu 
145                 150                 155                 160 


Glu Pro Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Ile 
                165                 170                 175     


Met Met Leu Ala Trp Lys Ile Ala Pro Ala Leu Ala Met Gly Asn Val 
            180                 185                 190         


Cys Ile Leu Lys Pro Ala Ala Val Thr Pro Leu Asn Ala Leu Tyr Phe 
        195                 200                 205             


Ala Ser Leu Cys Lys Lys Val Gly Ile Pro Ala Gly Val Val Asn Ile 
    210                 215                 220                 


Val Pro Gly Pro Gly Arg Thr Val Gly Ala Ala Leu Thr Asn Asp Pro 
225                 230                 235                 240 


Arg Ile Arg Lys Leu Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Ser 
                245                 250                 255     


Val Ala Val Asp Ser Ser Glu Ser Asn Leu Lys Lys Ile Thr Leu Glu 
            260                 265                 270         


Leu Gly Gly Lys Ser Ala His Leu Val Phe Asp Asp Ala Asn Ile Lys 
        275                 280                 285             


Lys Thr Leu Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly Gln 
    290                 295                 300                 


Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val Gln Glu Gly Ile Tyr Asp 
305                 310                 315                 320 


Glu Leu Leu Ala Ala Phe Lys Ala Tyr Leu Glu Thr Glu Ile Lys Val 
                325                 330                 335     


Gly Asn Pro Phe Asp Lys Ala Asn Phe Gln Gly Ala Ile Thr Asn Arg 
            340                 345                 350         


Gln Gln Phe Asp Thr Ile Met Asn Tyr Ile Asp Ile Gly Lys Lys Glu 
        355                 360                 365             


Gly Ala Lys Ile Leu Thr Gly Gly Glu Lys Val Gly Asp Lys Gly Tyr 
    370                 375                 380                 


Phe Ile Arg Pro Thr Val Phe Tyr Asp Val Asn Glu Asp Met Arg Ile 
385                 390                 395                 400 


Val Lys Glu Glu Ile Phe Gly Pro Val Val Thr Val Ala Lys Phe Lys 
                405                 410                 415     


Thr Leu Glu Glu Gly Val Glu Met Ala Asn Ser Ser Glu Phe Gly Leu 
            420                 425                 430         


Gly Ser Gly Ile Glu Thr Glu Ser Leu Ser Thr Gly Leu Lys Val Ala 
        435                 440                 445             


Lys Met Leu Lys Ala Gly Thr Val Trp Ile Asn Thr Tyr Asn Asp Phe 
    450                 455                 460                 


Asp Ser Arg Val Pro Phe Gly Gly Val Lys Gln Ser Gly Tyr Gly Arg 
465                 470                 475                 480 


Glu Met Gly Glu Glu Val Tyr His Ala Tyr Thr Glu Val Lys Ala Val 
                485                 490                 495     


Arg Ile Lys Leu 
            500 


<210>  64
<211>  1500
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  64
atgaccaagc ttcacttcga caccgcagaa ccggttaaga tcaccctgcc aaacggcctc       60

acttatgaac agcccaccgg cctgttcatc aacaacaaat tcatgaaggc gcaggatggc      120

aagacctacc cggtcgagga cccatcgacg gagaatactg tttgtgaagt gtcctcggcg      180

acgactgaag atgtcgagta tgcaatcgag tgcgctgatc gagcattcca tgatactgaa      240

tgggcgacac aagatcctcg tgagcgtggt cgtctgctct ccaagcttgc ggacgagctt      300

gaatcccaaa ttgatctggt gtcttctatt gaagctctcg ataatggaaa aaccctcgct      360

ctggcccgcg gtgacgtgac catcgctatt aactgcctgc gcgacgcggc agcttacgca      420

gataaggtca atggccgcac cattaacaca ggcgatggtt atatgaattt tacaaccttg      480

gagcctattg gagtgtgcgg ccagattatc ccatggaact tccccatcat gatgctcgct      540

tggaagattg ccccagccct tgcaatggga aacgtttgca ttctgaaacc ggccgcagtg      600

acgcccctga atgctctgta tttcgcatct ctgtgtaaga aggtaggtat ccccgctggc      660

gtcgttaaca ttgttcctgg tccaggtcgt actgtaggag cggcgctcac caacgatccg      720

cgcatccgta aactggcgtt caccggatcg acggaagtgg gtaagtccgt cgcagtcgac      780

tcttccgaat ctaatctcaa gaagattacg ctcgaactcg gcggcaaatc tgcacacctc      840

gtcttcgatg atgctaatat caagaaaacc ttgccgaacc tcgtcaacgg tattttcaag      900

aatgcgggcc aaatctgctc ctccggcagc cgtatctacg ttcaggaagg tatttacgac      960

gagctgctcg cagccttcaa ggcgtatctg gagacggaaa ttaaggtggg caacccattt     1020

gataaagcca actttcaggg cgctattact aatcgccagc agtttgacac cattatgaac     1080

tacattgata ttggtaagaa ggaaggcgct aagattctca ctggaggaga aaaggttggt     1140

gacaaaggat actttatccg tcccactgta ttctacgatg tgaacgaaga catgcgcatt     1200

gtgaaggaag aaattttcgg tccagttgtt acagtggcaa agttcaaaac cctcgaggaa     1260

ggtgttgaga tggctaatag cagcgagttc ggcctgggat caggcattga gacagaatcc     1320

ctttcgaccg gcctgaaggt ggccaagatg ttgaaggctg gcacagtttg gatcaatacc     1380

tataatgatt ttgactcccg tgttccgttt ggcggcgtga aacaatccgg ttacggccgc     1440

gaaatgggcg aggaggtgta ccacgcatac accgaagtga aggcagttcg aatcaaattg     1500


<210>  65
<211>  348
<212>  PRT
<213>  S. cerevisiae S288c

<400>  65

Met Ser Ile Pro Glu Thr Gln Lys Ala Ile Ile Phe Tyr Glu Ser Asn 
1               5                   10                  15      


Gly Lys Leu Glu His Lys Asp Ile Pro Val Pro Lys Pro Lys Pro Asn 
            20                  25                  30          


Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu 
        35                  40                  45              


His Ala Trp His Gly Asp Trp Pro Leu Pro Thr Lys Leu Pro Leu Val 
    50                  55                  60                  


Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val 
65                  70                  75                  80  


Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly 
                85                  90                  95      


Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys 
            100                 105                 110         


Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Glu 
        115                 120                 125             


Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr 
    130                 135                 140                 


Asp Leu Ala Glu Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr 
145                 150                 155                 160 


Lys Ala Leu Lys Ser Ala Asn Leu Arg Ala Gly His Trp Ala Ala Ile 
                165                 170                 175     


Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys 
            180                 185                 190         


Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Pro Gly Lys Glu 
        195                 200                 205             


Glu Leu Phe Thr Ser Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys 
    210                 215                 220                 


Glu Lys Asp Ile Val Ser Ala Val Val Lys Ala Thr Asn Gly Gly Ala 
225                 230                 235                 240 


His Gly Ile Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser 
                245                 250                 255     


Thr Arg Tyr Cys Arg Ala Asn Gly Thr Val Val Leu Val Gly Leu Pro 
            260                 265                 270         


Ala Gly Ala Lys Cys Ser Ser Asp Val Phe Asn His Val Val Lys Ser 
        275                 280                 285             


Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu 
    290                 295                 300                 


Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val 
305                 310                 315                 320 


Val Gly Leu Ser Ser Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly 
                325                 330                 335     


Gln Ile Ala Gly Arg Tyr Val Val Asp Thr Ser Lys 
            340                 345             


<210>  66
<211>  1044
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  66
atgtccatcc cggaaaccca gaaagccatt atcttttacg agagcaacgg caagctcgaa       60

cataaggata ttccagtgcc aaaaccgaag ccaaacgagc tcctgatcaa cgttaagtac      120

tccggagtgt gccacacgga tctgcacgct tggcatggcg attggcccct ccctactaag      180

ctgccactgg tcggcggaca cgaaggcgct ggtgtggtgg tgggaatggg tgagaacgtt      240

aaaggctgga agattggcga ctacgctggc atcaaatggc tgaatggttc ctgcatggct      300

tgtgaatact gtgagcttgg taatgaaagc aactgcccgc acgccgattt gagcggatac      360

acacatgatg gctccttcca ggagtacgct accgccgacg ctgtgcaagc agcgcacatt      420

ccacaaggca ccgacctcgc tgaagttgct ccaatcctgt gtgctggcat caccgtatac      480

aaggctctca aatccgcaaa cctgcgcgcg ggccactggg cagcgatttc aggcgctgcc      540

ggcggtctcg gttccttggc tgtgcaatac gcaaaggcta tgggataccg agtactggga      600

attgacggcg gaccaggaaa agaggaactt ttcacgtccc tcggcggcga ggtcttcatc      660

gattttacca aagagaagga catcgtctcc gctgtcgtga aggcaactaa cggcggcgct      720

cacggtatca tcaacgtgtc tgtttcggag gcggctatcg aggctagcac ccgatactgc      780

cgtgcaaatg gcacggtcgt gttggttggc ctgccagcgg gcgcaaagtg ctcttctgat      840

gtcttcaacc atgttgttaa gtccatttcg attgtgggct catacgttgg caatcgcgct      900

gacactcgtg aggcgttgga cttcttcgcg cgcggcctcg taaagtcgcc tatcaaggtt      960

gtcggtttga gcagcctgcc cgaaatctac gaaaaaatgg aaaagggtca aattgccggc     1020

cgatatgtcg tcgatacctc taaa                                            1044


<210>  67
<211>  497
<212>  PRT
<213>  Yarrowia lipolytica CLIB 122 / E 150

<400>  67

Met Ser Ala Lys Ser Ile His Glu Ala Asp Gly Lys Ala Leu Leu Ala 
1               5                   10                  15      


His Phe Leu Ser Lys Ala Pro Val Trp Ala Glu Gln Gln Pro Ile Asn 
            20                  25                  30          


Thr Phe Glu Met Gly Thr Pro Lys Leu Ala Ser Leu Thr Phe Glu Asp 
        35                  40                  45              


Gly Val Ala Pro Glu Gln Ile Phe Ala Ala Ala Glu Lys Thr Tyr Pro 
    50                  55                  60                  


Trp Leu Leu Glu Ser Gly Ala Lys Phe Val Ala Lys Pro Asp Gln Leu 
65                  70                  75                  80  


Ile Lys Arg Arg Gly Lys Ala Gly Leu Leu Val Leu Asn Lys Ser Trp 
                85                  90                  95      


Glu Glu Cys Lys Pro Trp Ile Ala Glu Arg Ala Ala Lys Pro Ile Asn 
            100                 105                 110         


Val Glu Gly Ile Asp Gly Val Leu Arg Thr Phe Leu Val Glu Pro Phe 
        115                 120                 125             


Val Pro His Asp Gln Lys His Glu Tyr Tyr Ile Asn Ile His Ser Val 
    130                 135                 140                 


Arg Glu Gly Asp Trp Ile Leu Phe Tyr His Glu Gly Gly Val Asp Val 
145                 150                 155                 160 


Gly Asp Val Asp Ala Lys Ala Ala Lys Ile Leu Ile Pro Val Asp Ile 
                165                 170                 175     


Glu Asn Glu Tyr Pro Ser Asn Ala Thr Leu Thr Lys Glu Leu Leu Ala 
            180                 185                 190         


His Val Pro Glu Asp Gln His Gln Thr Leu Leu Asp Phe Ile Asn Arg 
        195                 200                 205             


Leu Tyr Ala Val Tyr Val Asp Leu Gln Phe Thr Tyr Leu Glu Ile Asn 
    210                 215                 220                 


Pro Leu Val Val Ile Pro Thr Ala Gln Gly Val Glu Val His Tyr Leu 
225                 230                 235                 240 


Asp Leu Ala Gly Lys Leu Asp Gln Thr Ala Glu Phe Glu Cys Gly Pro 
                245                 250                 255     


Lys Trp Ala Ala Ala Arg Ser Pro Ala Ala Leu Gly Gln Val Val Thr 
            260                 265                 270         


Ile Asp Ala Gly Ser Thr Lys Val Ser Ile Asp Ala Gly Pro Ala Met 
        275                 280                 285             


Val Phe Pro Ala Pro Phe Gly Arg Glu Leu Ser Lys Glu Glu Ala Tyr 
    290                 295                 300                 


Ile Ala Glu Leu Asp Ser Lys Thr Gly Ala Ser Leu Lys Leu Thr Val 
305                 310                 315                 320 


Leu Asn Ala Lys Gly Arg Ile Trp Thr Leu Val Ala Gly Gly Gly Ala 
                325                 330                 335     


Ser Val Val Tyr Ala Asp Ala Ile Ala Ser Ala Gly Phe Ala Asp Glu 
            340                 345                 350         


Leu Ala Asn Tyr Gly Glu Tyr Ser Gly Ala Pro Asn Glu Thr Gln Thr 
        355                 360                 365             


Tyr Glu Tyr Ala Lys Thr Val Leu Asp Leu Met Thr Arg Gly Asp Ala 
    370                 375                 380                 


His Pro Glu Gly Lys Val Leu Phe Ile Gly Gly Gly Ile Ala Asn Phe 
385                 390                 395                 400 


Thr Gln Val Gly Ser Thr Phe Lys Gly Ile Ile Arg Ala Phe Arg Asp 
                405                 410                 415     


Tyr Gln Ser Ser Leu His Asn His Lys Val Lys Ile Tyr Val Arg Arg 
            420                 425                 430         


Gly Gly Pro Asn Trp Gln Glu Gly Leu Arg Leu Ile Lys Ser Ala Gly 
        435                 440                 445             


Asp Glu Leu Asn Leu Pro Met Glu Ile Tyr Gly Pro Asp Met His Val 
    450                 455                 460                 


Ser Gly Ile Val Pro Leu Ala Leu Leu Gly Lys Arg Pro Lys Asn Val 
465                 470                 475                 480 


Lys Pro Phe Gly Thr Gly Pro Ser Thr Glu Ala Ser Thr Pro Leu Gly 
                485                 490                 495     


Val 
    


<210>  68
<211>  1491
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  68
atgagcgcca agagcatcca cgaggctgat ggcaaagcac tccttgccca cttcttgtcc       60

aaagcaccag tctgggcaga gcaacagccc atcaatacct ttgagatggg tacccccaaa      120

ctggcaagcc tgactttcga ggatggtgta gcgcctgagc aaatcttcgc cgctgcagaa      180

aaaacctacc cgtggctgct tgaatcaggt gctaagttcg tcgccaagcc tgatcagctg      240

attaagcgac gtggtaaggc gggcttgctt gtgcttaaca aatcctggga agaatgtaag      300

ccctggattg ccgagcgcgc agcgaagcct attaatgtag agggaatcga cggcgtgttg      360

cgtacctttc tcgttgaacc atttgtcccc catgatcaga agcatgaata ttacatcaac      420

atccatagcg tccgcgaagg tgattggatc ctgttttacc acgaaggtgg tgtcgacgtg      480

ggcgacgttg atgctaaggc agcaaaaatc ctgatcccgg ttgatattga aaacgagtac      540

ccatcaaatg caaccctcac caaggagctt ttggctcatg tgcctgaaga tcagcaccaa      600

accttgctcg atttcatcaa ccgcctctac gcggtatacg tagatctgca attcacctac      660

ttggaaatta acccgctcgt ggtgattcct acggctcagg gagtcgaggt gcactatctc      720

gatttggcag gtaagttgga ccagaccgca gaattcgaat gtggacctaa atgggcggcc      780

gctcgttccc ccgcggcctt gggacaggtc gttacgatcg acgcgggtag caccaaggtc      840

tcgattgacg ctggtccagc catggtgttc ccagccccgt ttggccgcga actgagcaaa      900

gaagaagcat acatcgcgga actggattct aagacgggtg cctctctcaa gcttactgtc      960

ttgaacgcaa agggccgcat ctggaccctt gtcgcaggtg gaggagcaag cgtggtctac     1020

gcagacgcga tcgcctccgc tggatttgct gatgaactgg ctaattacgg agagtactcg     1080

ggtgcaccga acgagaccca gacttatgaa tatgccaaga ccgtcctcga tctcatgacc     1140

cgtggagacg cgcacccaga gggaaaggtg ctgttcatcg gcggaggcat cgccaacttc     1200

acccaggtag gctccacttt caaaggtatt atccgcgcct tccgtgacta ccaatcatcc     1260

cttcacaatc acaaggttaa gatctacgtc cgccgcggtg gtccaaactg gcaggaaggt     1320

ctgcgactta tcaaatctgc aggcgacgag ctgaatctcc caatggagat ttacggccca     1380

gatatgcacg tcagcggcat cgtgcccctc gctctgttgg gtaaacgccc taagaatgtg     1440

aagccattcg gaaccggccc ttccactgag gcatcgactc cactgggtgt g              1491


<210>  69
<211>  887
<212>  PRT
<213>  E. coli (strain K12)

<400>  69

Met Ser Glu Arg Phe Pro Asn Asp Val Asp Pro Ile Glu Thr Arg Asp 
1               5                   10                  15      


Trp Leu Gln Ala Ile Glu Ser Val Ile Arg Glu Glu Gly Val Glu Arg 
            20                  25                  30          


Ala Gln Tyr Leu Ile Asp Gln Leu Leu Ala Glu Ala Arg Lys Gly Gly 
        35                  40                  45              


Val Asn Val Ala Ala Gly Thr Gly Ile Ser Asn Tyr Ile Asn Thr Ile 
    50                  55                  60                  


Pro Val Glu Glu Gln Pro Glu Tyr Pro Gly Asn Leu Glu Leu Glu Arg 
65                  70                  75                  80  


Arg Ile Arg Ser Ala Ile Arg Trp Asn Ala Ile Met Thr Val Leu Arg 
                85                  90                  95      


Ala Ser Lys Lys Asp Leu Glu Leu Gly Gly His Met Ala Ser Phe Gln 
            100                 105                 110         


Ser Ser Ala Thr Ile Tyr Asp Val Cys Phe Asn His Phe Phe Arg Ala 
        115                 120                 125             


Arg Asn Glu Gln Asp Gly Gly Asp Leu Val Tyr Phe Gln Gly His Ile 
    130                 135                 140                 


Ser Pro Gly Val Tyr Ala Arg Ala Phe Leu Glu Gly Arg Leu Thr Gln 
145                 150                 155                 160 


Glu Gln Leu Asp Asn Phe Arg Gln Glu Val His Gly Asn Gly Leu Ser 
                165                 170                 175     


Ser Tyr Pro His Pro Lys Leu Met Pro Glu Phe Trp Gln Phe Pro Thr 
            180                 185                 190         


Val Ser Met Gly Leu Gly Pro Ile Gly Ala Ile Tyr Gln Ala Lys Phe 
        195                 200                 205             


Leu Lys Tyr Leu Glu His Arg Gly Leu Lys Asp Thr Ser Lys Gln Thr 
    210                 215                 220                 


Val Tyr Ala Phe Leu Gly Asp Gly Glu Met Asp Glu Pro Glu Ser Lys 
225                 230                 235                 240 


Gly Ala Ile Thr Ile Ala Thr Arg Glu Lys Leu Asp Asn Leu Val Phe 
                245                 250                 255     


Val Ile Asn Cys Asn Leu Gln Arg Leu Asp Gly Pro Val Thr Gly Asn 
            260                 265                 270         


Gly Lys Ile Ile Asn Glu Leu Glu Gly Ile Phe Glu Gly Ala Gly Trp 
        275                 280                 285             


Asn Val Ile Lys Val Met Trp Gly Ser Arg Trp Asp Glu Leu Leu Arg 
    290                 295                 300                 


Lys Asp Thr Ser Gly Lys Leu Ile Gln Leu Met Asn Glu Thr Val Asp 
305                 310                 315                 320 


Gly Asp Tyr Gln Thr Phe Lys Ser Lys Asp Gly Ala Tyr Val Arg Glu 
                325                 330                 335     


His Phe Phe Gly Lys Tyr Pro Glu Thr Ala Ala Leu Val Ala Asp Trp 
            340                 345                 350         


Thr Asp Glu Gln Ile Trp Ala Leu Asn Arg Gly Gly His Asp Pro Lys 
        355                 360                 365             


Lys Ile Tyr Ala Ala Phe Lys Lys Ala Gln Glu Thr Lys Gly Lys Ala 
    370                 375                 380                 


Thr Val Ile Leu Ala His Thr Ile Lys Gly Tyr Gly Met Gly Asp Ala 
385                 390                 395                 400 


Ala Glu Gly Lys Asn Ile Ala His Gln Val Lys Lys Met Asn Met Asp 
                405                 410                 415     


Gly Val Arg His Ile Arg Asp Arg Phe Asn Val Pro Val Ser Asp Ala 
            420                 425                 430         


Asp Ile Glu Lys Leu Pro Tyr Ile Thr Phe Pro Glu Gly Ser Glu Glu 
        435                 440                 445             


His Thr Tyr Leu His Ala Gln Arg Gln Lys Leu His Gly Tyr Leu Pro 
    450                 455                 460                 


Ser Arg Gln Pro Asn Phe Thr Glu Lys Leu Glu Leu Pro Ser Leu Gln 
465                 470                 475                 480 


Asp Phe Gly Ala Leu Leu Glu Glu Gln Ser Lys Glu Ile Ser Thr Thr 
                485                 490                 495     


Ile Ala Phe Val Arg Ala Leu Asn Val Met Leu Lys Asn Lys Ser Ile 
            500                 505                 510         


Lys Asp Arg Leu Val Pro Ile Ile Ala Asp Glu Ala Arg Thr Phe Gly 
        515                 520                 525             


Met Glu Gly Leu Phe Arg Gln Ile Gly Ile Tyr Ser Pro Asn Gly Gln 
    530                 535                 540                 


Gln Tyr Thr Pro Gln Asp Arg Glu Gln Val Ala Tyr Tyr Lys Glu Asp 
545                 550                 555                 560 


Glu Lys Gly Gln Ile Leu Gln Glu Gly Ile Asn Glu Leu Gly Ala Gly 
                565                 570                 575     


Cys Ser Trp Leu Ala Ala Ala Thr Ser Tyr Ser Thr Asn Asn Leu Pro 
            580                 585                 590         


Met Ile Pro Phe Tyr Ile Tyr Tyr Ser Met Phe Gly Phe Gln Arg Ile 
        595                 600                 605             


Gly Asp Leu Cys Trp Ala Ala Gly Asp Gln Gln Ala Arg Gly Phe Leu 
    610                 615                 620                 


Ile Gly Gly Thr Ser Gly Arg Thr Thr Leu Asn Gly Glu Gly Leu Gln 
625                 630                 635                 640 


His Glu Asp Gly His Ser His Ile Gln Ser Leu Thr Ile Pro Asn Cys 
                645                 650                 655     


Ile Ser Tyr Asp Pro Ala Tyr Ala Tyr Glu Val Ala Val Ile Met His 
            660                 665                 670         


Asp Gly Leu Glu Arg Met Tyr Gly Glu Lys Gln Glu Asn Val Tyr Tyr 
        675                 680                 685             


Tyr Ile Thr Thr Leu Asn Glu Asn Tyr His Met Pro Ala Met Pro Glu 
    690                 695                 700                 


Gly Ala Glu Glu Gly Ile Arg Lys Gly Ile Tyr Lys Leu Glu Thr Ile 
705                 710                 715                 720 


Glu Gly Ser Lys Gly Lys Val Gln Leu Leu Gly Ser Gly Ser Ile Leu 
                725                 730                 735     


Arg His Val Arg Glu Ala Ala Glu Ile Leu Ala Lys Asp Tyr Gly Val 
            740                 745                 750         


Gly Ser Asp Val Tyr Ser Val Thr Ser Phe Thr Glu Leu Ala Arg Asp 
        755                 760                 765             


Gly Gln Asp Cys Glu Arg Trp Asn Met Leu His Pro Leu Glu Thr Pro 
    770                 775                 780                 


Arg Val Pro Tyr Ile Ala Gln Val Met Asn Asp Ala Pro Ala Val Ala 
785                 790                 795                 800 


Ser Thr Asp Tyr Met Lys Leu Phe Ala Glu Gln Val Arg Thr Tyr Val 
                805                 810                 815     


Pro Ala Asp Asp Tyr Arg Val Leu Gly Thr Asp Gly Phe Gly Arg Ser 
            820                 825                 830         


Asp Ser Arg Glu Asn Leu Arg His His Phe Glu Val Asp Ala Ser Tyr 
        835                 840                 845             


Val Val Val Ala Ala Leu Gly Glu Leu Ala Lys Arg Gly Glu Ile Asp 
    850                 855                 860                 


Lys Lys Val Val Ala Asp Ala Ile Ala Lys Phe Asn Ile Asp Ala Asp 
865                 870                 875                 880 


Lys Val Asn Pro Arg Leu Ala 
                885         


<210>  70
<211>  2661
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  70
atgagcgagc gcttccccaa tgacgttgat cccattgaga cccgcgattg gttgcaggcg       60

atcgagtcgg tcatccgtga ggagggagtc gaacgagccc agtatttgat cgatcaactg      120

cttgcagaag cccgcaaggg aggcgtgaat gtcgcggctg gtaccggcat tagcaattac      180

atcaacacca tcccagtcga ggagcaacca gagtaccctg gtaatcttga actcgaacgc      240

cgtattcgca gcgccattcg ctggaacgca attatgaccg ttctgcgcgc gtcaaagaaa      300

gacctcgaac tgggaggtca tatggcatcc tttcaatcct cagccaccat ctacgacgtt      360

tgctttaacc acttcttccg cgcgcgtaat gaacaagatg gcggagacct ggtttatttt      420

cagggtcata tctcgccggg cgtctacgca cgcgccttcc tggaaggacg cctgacgcaa      480

gaacagctcg acaatttccg acaagaagtg cacggcaacg gactgtcctc ttacccgcat      540

ccaaaactga tgcctgagtt ctggcaattt ccaacggtgt ccatgggtct cggcccaatc      600

ggtgcaatct accaggcaaa gtttctgaag tacctggagc accgcggcct caaagatacg      660

tccaagcaaa ccgtctacgc gtttctgggt gacggagaaa tggatgagcc tgaatccaag      720

ggcgctatta cgattgccac tcgcgaaaag ctcgacaacc tggtcttcgt catcaattgc      780

aacctgcaac gattggacgg tccggttacg ggcaatggca agatcattaa tgagctcgaa      840

ggcatcttcg agggcgctgg ctggaacgtg attaaggtga tgtggggttc tcgctgggac      900

gaactgctgc gcaaagacac cagcggcaag ctgattcagc tgatgaacga gaccgtggat      960

ggtgattacc agaccttcaa gtccaaggat ggagcctacg tccgtgagca cttttttgga     1020

aaatatcctg aaacggcagc attggtggca gattggaccg acgagcagat ctgggcgctg     1080

aatcgcggtg gccatgaccc taagaaaatc tacgcggcct tcaagaaggc acaagaaacc     1140

aagggcaaag ccactgtcat cttggcgcat accatcaaag gctacggtat gggcgatgcc     1200

gctgagggca aaaacatcgc tcatcaagtt aagaagatga acatggatgg tgtccgccac     1260

atccgcgatc gctttaacgt ccccgtctct gacgcagata ttgagaagct gccatacatc     1320

accttcccag aaggctccga ggaacatacc tatctccacg cacagcgcca gaagctccat     1380

ggttaccttc cgtcgcgtca gccaaatttc accgaaaaat tggaattgcc ctcattgcaa     1440

gattttggcg cgctcttgga ggaacagtct aaagagatct ctacaaccat cgcgtttgtg     1500

cgtgccctca acgtcatgtt gaagaacaag tctatcaagg atcgattggt gcccattatc     1560

gctgatgaag cccgcacctt cggtatggag ggtttgtttc gccagattgg catctactct     1620

cccaatggcc agcaatacac cccacaggat cgcgaacaag ttgcctacta taaggaagac     1680

gagaaaggcc agatccttca agaaggcatc aacgaacttg gcgcgggatg cagctggctc     1740

gccgctgcca caagctactc aactaacaac ctcccgatga tccctttcta tatctactat     1800

tcgatgttcg gcttccaacg cattggcgac ttgtgctggg cggcaggcga tcaacaagcc     1860

cgcggctttc tgattggcgg tacttcgggt cgcactacgc tcaacggcga aggtctccag     1920

catgaggatg gtcattcgca catccaatca ctcaccattc caaactgtat ttcctatgac     1980

cccgcatacg cttacgaggt tgcggtcatc atgcacgatg gtctggaacg tatgtacggc     2040

gagaagcagg aaaatgtgta ttactacatc accaccctga atgaaaatta ccatatgcct     2100

gccatgcctg agggtgcgga agagggaatt cgtaagggta tctacaagct ggaaacaatt     2160

gaaggatcca agggtaaggt acagcttctg ggatctggct ccattcttcg tcatgtgcgc     2220

gaagcagcgg aaatcctcgc aaaagattac ggcgtaggca gcgacgttta ctccgttacg     2280

agcttcactg aactggcccg cgacggccag gactgtgagc gttggaacat gctgcatccc     2340

cttgaaaccc cacgcgtgcc gtatatcgca caagtaatga atgacgcccc tgccgtcgcc     2400

tcgactgact atatgaagct cttcgccgaa caggtccgca cgtacgttcc agcagatgat     2460

taccgcgttc tgggcaccga cggctttggc cgctccgatt cacgcgagaa cctgcgacac     2520

cacttcgagg tcgacgcttc ctacgtggta gtagctgcgc tcggagaact ggcaaagcgt     2580

ggcgagatcg acaaaaaggt agttgctgat gctatcgcta agttcaacat tgacgccgac     2640

aaggtcaatc cccgcttggc a                                               2661


<210>  71
<211>  120
<212>  PRT
<213>  S. cerevisiae S288c

<400>  71

Met Pro Lys Val Tyr Ser Tyr Gln Glu Val Ala Glu His Asn Gly Pro 
1               5                   10                  15      


Glu Asn Phe Trp Ile Ile Ile Asp Asp Lys Val Tyr Asp Val Ser Gln 
            20                  25                  30          


Phe Lys Asp Glu His Pro Gly Gly Asp Glu Ile Ile Met Asp Leu Gly 
        35                  40                  45              


Gly Gln Asp Ala Thr Glu Ser Phe Val Asp Ile Gly His Ser Asp Glu 
    50                  55                  60                  


Ala Leu Arg Leu Leu Lys Gly Leu Tyr Ile Gly Asp Val Asp Lys Thr 
65                  70                  75                  80  


Ser Glu Arg Val Ser Val Glu Lys Val Ser Thr Ser Glu Asn Gln Ser 
                85                  90                  95      


Lys Gly Ser Gly Thr Leu Val Val Ile Leu Ala Ile Leu Met Leu Gly 
            100                 105                 110         


Val Ala Tyr Tyr Leu Leu Asn Glu 
        115                 120 


<210>  72
<211>  360
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  72
atgccaaagg tctattctta tcaggaagtc gcagaacaca acggcccaga aaacttctgg       60

atcattatcg atgataaggt ttacgatgtg tcgcagttca aagacgaaca cccaggtgga      120

gatgaaatta ttatggatct tggcggacaa gatgcgacgg aaagctttgt tgatatcggt      180

cactcagacg aagccttgcg cctcctcaag ggcctttaca tcggtgacgt agataaaacc      240

tcggagcgcg tttccgtcga gaaagtttcc acctcagaga accaatccaa aggctccggt      300

accctcgtgg tgatcctcgc tattctgatg ttgggtgtcg cctattatct tctgaatgag      360


<210>  73
<211>  485
<212>  PRT
<213>  Emericella nidulans ATCC 38163

<400>  73

Met Ser Ala Lys Ser Ile Phe Glu Ala Asp Gly Lys Ala Ile Leu Asn 
1               5                   10                  15      


Tyr His Leu Thr Arg Ala Pro Val Ile Lys Pro Thr Pro Leu Pro Pro 
            20                  25                  30          


Ser Asn Thr His Asn Pro Pro Pro Lys Leu Ala Ser Leu Tyr Phe Pro 
        35                  40                  45              


Asp Asp Leu Ser Val Lys Asp Val Leu Asp Gln Ala Glu Val Thr Tyr 
    50                  55                  60                  


Pro Trp Leu Leu Thr Pro Gly Ser Lys Phe Val Ala Lys Pro Asp Gln 
65                  70                  75                  80  


Leu Ile Lys Arg Arg Gly Lys Ser Gly Leu Leu Ala Leu Asn Lys Thr 
                85                  90                  95      


Trp Ala Glu Ala Arg Glu Trp Ile Glu Ala Arg Ala Thr Lys Glu Gln 
            100                 105                 110         


Gln Val Glu Thr Val Val Gly Val Leu Arg His Phe Leu Val Glu Pro 
        115                 120                 125             


Phe Val Pro His Pro Gln Glu Thr Glu Tyr Tyr Ile Asn Ile His Ser 
    130                 135                 140                 


Val Arg Glu Gly Asp Trp Ile Leu Phe Thr His Glu Gly Gly Val Asp 
145                 150                 155                 160 


Val Gly Asp Val Asp Ala Lys Ala Glu Lys Leu Leu Ile Pro Val Asn 
                165                 170                 175     


Leu Lys Asn Tyr Pro Ser Asn Glu Glu Ile Ala Ser Ala Leu Leu Ser 
            180                 185                 190         


Lys Val Pro Lys Gly Ile His Asn Val Leu Val Asp Phe Ile Ser Arg 
        195                 200                 205             


Leu Tyr Ala Val Tyr Val Asp Cys Gln Phe Thr Tyr Leu Glu Ile Asn 
    210                 215                 220                 


Pro Leu Val Val Ile Pro Asn Ala Asp Ala Thr Ser Ala Asp Val His 
225                 230                 235                 240 


Phe Leu Asp Leu Ala Ala Lys Leu Asp Gln Thr Ala Glu Phe Glu Cys 
                245                 250                 255     


Gly Thr Lys Trp Ala Val Ala Arg Ser Pro Ala Asn Leu Gly Leu Ala 
            260                 265                 270         


Ala Leu Pro Thr Ser Asp Lys Val Asn Ile Asp Ala Gly Pro Pro Met 
        275                 280                 285             


Glu Phe Pro Ala Pro Phe Gly Arg Glu Leu Ser Lys Glu Glu Lys Phe 
    290                 295                 300                 


Ile Ser Asp Met Asp Ala Lys Thr Gly Ala Ser Leu Lys Leu Thr Val 
305                 310                 315                 320 


Leu Asn Pro Asn Gly Arg Val Trp Thr Leu Val Ala Gly Gly Gly Ala 
                325                 330                 335     


Ser Val Val Tyr Ala Asp Ala Ile Ala Ser Ala Gly Phe Val Ser Glu 
            340                 345                 350         


Leu Ala Asn Tyr Gly Glu Tyr Ser Gly Ala Pro Thr Glu Thr Gln Thr 
        355                 360                 365             


Phe Asn Tyr Ala Arg Thr Ile Leu Asp Leu Met Leu Arg Ser Pro Ile 
    370                 375                 380                 


His Pro Asp Gly Lys Val Leu Phe Ile Gly Gly Gly Ile Ala Asn Phe 
385                 390                 395                 400 


Thr Asn Val Ala Ser Thr Phe Lys Gly Val Ile Arg Ala Leu Arg Glu 
                405                 410                 415     


Val Ala Pro Val Leu Asn Glu His Lys Val Gln Ile Trp Val Arg Arg 
            420                 425                 430         


Ala Gly Pro Asn Tyr Gln Glu Gly Leu Lys Asn Ile Lys Ala Val Gly 
        435                 440                 445             


Glu Glu Leu Gly Leu Asn Met His Val Tyr Gly Pro Glu Met His Val 
    450                 455                 460                 


Ser Gly Ile Val Pro Leu Ala Leu Gln Gly Lys Gln Thr Asp Ile Lys 
465                 470                 475                 480 


Glu Phe Gly Thr Ala 
                485 


<210>  74
<211>  1455
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  74
atgtcggcca agtcgatctt cgaagcagac ggaaaagcaa ttttgaatta ccacctgacc       60

cgcgcaccag tgatcaaacc aacccctctg ccaccttcca acactcataa cccccctccg      120

aaattggctt ctctctactt cccggacgac ttgtccgtga aggacgttct cgatcaagca      180

gaagttacat atccgtggct tcttacccca ggctccaaat ttgtggccaa acctgatcag      240

ttgatcaaac gtcgcggcaa atccggcctt ctggcgttga acaagacatg ggccgaagca      300

cgtgagtgga ttgaagctcg agcaactaag gaacaacagg tggaaactgt agtgggagtt      360

ctccgtcact tcctggttga accttttgtg cctcaccctc aggagacgga gtactacatt      420

aacatccact ccgtgcgcga gggtgactgg atcctcttta cccacgaggg cggtgtcgat      480

gtcggcgatg tcgacgccaa agcagagaag ctgttgatcc cggtgaatct caagaactac      540

ccctccaacg aggagatcgc atctgcattg ttgtccaagg tccctaaggg aatccataac      600

gtccttgtgg actttatctc ccgtctgtac gcggtctatg ttgattgtca atttacgtac      660

ctcgaaatca acccattggt cgtgattccc aacgcggacg caacttccgc tgatgttcat      720

tttcttgatc tcgctgcgaa gctggatcag acagccgaat tcgaatgcgg taccaagtgg      780

gccgtcgctc gttctcccgc caacttgggc ctcgcagcct tgcctacgag cgataaggtg      840

aacattgacg cgggacctcc gatggaattt cctgccccct ttggtcgcga gctgtcaaaa      900

gaagaaaaat ttatttccga catggatgct aagaccggag cgagccttaa gctcaccgtc      960

cttaatccga acggccgcgt gtggaccctc gtcgccggcg gaggtgcctc tgtggtatac     1020

gcagacgcga ttgcttctgc aggcttcgtg tccgaattgg ctaactacgg tgagtactcg     1080

ggcgcaccga ccgaaaccca aaccttcaac tacgcccgca ccatcttgga tctgatgctg     1140

cgctccccaa ttcacccgga cggtaaggtg cttttcattg gcggtggaat tgccaacttc     1200

acaaacgttg cgagcacctt caaaggagtg atccgtgctc tgcgtgaagt ggcaccagtt     1260

ttgaacgaac acaaagtgca gatctgggtg cgccgcgcag gtccaaatta ccaagaaggt     1320

ctgaaaaata tcaaagcggt tggtgaggaa ctcggactta acatgcatgt ctacggccca     1380

gaaatgcacg tcagcggcat tgtaccgctg gcactgcaag gcaagcaaac cgatattaaa     1440

gaattcggca ccgcg                                                      1455


<210>  75
<211>  630
<212>  PRT
<213>  E. coli (strain K12)

<400>  75

Met Ala Ile Glu Ile Lys Val Pro Asp Ile Gly Ala Asp Glu Val Glu 
1               5                   10                  15      


Ile Thr Glu Ile Leu Val Lys Val Gly Asp Lys Val Glu Ala Glu Gln 
            20                  25                  30          


Ser Leu Ile Thr Val Glu Gly Asp Lys Ala Ser Met Glu Val Pro Ser 
        35                  40                  45              


Pro Gln Ala Gly Ile Val Lys Glu Ile Lys Val Ser Val Gly Asp Lys 
    50                  55                  60                  


Thr Gln Thr Gly Ala Leu Ile Met Ile Phe Asp Ser Ala Asp Gly Ala 
65                  70                  75                  80  


Ala Asp Ala Ala Pro Ala Gln Ala Glu Glu Lys Lys Glu Ala Ala Pro 
                85                  90                  95      


Ala Ala Ala Pro Ala Ala Ala Ala Ala Lys Asp Val Asn Val Pro Asp 
            100                 105                 110         


Ile Gly Ser Asp Glu Val Glu Val Thr Glu Ile Leu Val Lys Val Gly 
        115                 120                 125             


Asp Lys Val Glu Ala Glu Gln Ser Leu Ile Thr Val Glu Gly Asp Lys 
    130                 135                 140                 


Ala Ser Met Glu Val Pro Ala Pro Phe Ala Gly Thr Val Lys Glu Ile 
145                 150                 155                 160 


Lys Val Asn Val Gly Asp Lys Val Ser Thr Gly Ser Leu Ile Met Val 
                165                 170                 175     


Phe Glu Val Ala Gly Glu Ala Gly Ala Ala Ala Pro Ala Ala Lys Gln 
            180                 185                 190         


Glu Ala Ala Pro Ala Ala Ala Pro Ala Pro Ala Ala Gly Val Lys Glu 
        195                 200                 205             


Val Asn Val Pro Asp Ile Gly Gly Asp Glu Val Glu Val Thr Glu Val 
    210                 215                 220                 


Met Val Lys Val Gly Asp Lys Val Ala Ala Glu Gln Ser Leu Ile Thr 
225                 230                 235                 240 


Val Glu Gly Asp Lys Ala Ser Met Glu Val Pro Ala Pro Phe Ala Gly 
                245                 250                 255     


Val Val Lys Glu Leu Lys Val Asn Val Gly Asp Lys Val Lys Thr Gly 
            260                 265                 270         


Ser Leu Ile Met Ile Phe Glu Val Glu Gly Ala Ala Pro Ala Ala Ala 
        275                 280                 285             


Pro Ala Lys Gln Glu Ala Ala Ala Pro Ala Pro Ala Ala Lys Ala Glu 
    290                 295                 300                 


Ala Pro Ala Ala Ala Pro Ala Ala Lys Ala Glu Gly Lys Ser Glu Phe 
305                 310                 315                 320 


Ala Glu Asn Asp Ala Tyr Val His Ala Thr Pro Leu Ile Arg Arg Leu 
                325                 330                 335     


Ala Arg Glu Phe Gly Val Asn Leu Ala Lys Val Lys Gly Thr Gly Arg 
            340                 345                 350         


Lys Gly Arg Ile Leu Arg Glu Asp Val Gln Ala Tyr Val Lys Glu Ala 
        355                 360                 365             


Ile Lys Arg Ala Glu Ala Ala Pro Ala Ala Thr Gly Gly Gly Ile Pro 
    370                 375                 380                 


Gly Met Leu Pro Trp Pro Lys Val Asp Phe Ser Lys Phe Gly Glu Ile 
385                 390                 395                 400 


Glu Glu Val Glu Leu Gly Arg Ile Gln Lys Ile Ser Gly Ala Asn Leu 
                405                 410                 415     


Ser Arg Asn Trp Val Met Ile Pro His Val Thr His Phe Asp Lys Thr 
            420                 425                 430         


Asp Ile Thr Glu Leu Glu Ala Phe Arg Lys Gln Gln Asn Glu Glu Ala 
        435                 440                 445             


Ala Lys Arg Lys Leu Asp Val Lys Ile Thr Pro Val Val Phe Ile Met 
    450                 455                 460                 


Lys Ala Val Ala Ala Ala Leu Glu Gln Met Pro Arg Phe Asn Ser Ser 
465                 470                 475                 480 


Leu Ser Glu Asp Gly Gln Arg Leu Thr Leu Lys Lys Tyr Ile Asn Ile 
                485                 490                 495     


Gly Val Ala Val Asp Thr Pro Asn Gly Leu Val Val Pro Val Phe Lys 
            500                 505                 510         


Asp Val Asn Lys Lys Gly Ile Ile Glu Leu Ser Arg Glu Leu Met Thr 
        515                 520                 525             


Ile Ser Lys Lys Ala Arg Asp Gly Lys Leu Thr Ala Gly Glu Met Gln 
    530                 535                 540                 


Gly Gly Cys Phe Thr Ile Ser Ser Ile Gly Gly Leu Gly Thr Thr His 
545                 550                 555                 560 


Phe Ala Pro Ile Val Asn Ala Pro Glu Val Ala Ile Leu Gly Val Ser 
                565                 570                 575     


Lys Ser Ala Met Glu Pro Val Trp Asn Gly Lys Glu Phe Val Pro Arg 
            580                 585                 590         


Leu Met Leu Pro Ile Ser Leu Ser Phe Asp His Arg Val Ile Asp Gly 
        595                 600                 605             


Ala Asp Gly Ala Arg Phe Ile Thr Ile Ile Asn Asn Thr Leu Ser Asp 
    610                 615                 620                 


Ile Arg Arg Leu Val Met 
625                 630 


<210>  76
<211>  1890
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  76
atggccatcg aaatcaaggt gccagacatc ggtgccgatg aagtcgaaat caccgagatt       60

ctcgtcaaag tcggcgataa agtggaagca gaacagtcct tgatcaccgt agagggtgat      120

aaggctagca tggaagttcc tagcccgcag gctggcattg tgaaggaaat taaggtttca      180

gttggtgaca aaactcaaac gggagccctt attatgatct tcgactcggc agacggagct      240

gccgatgcgg cgccggccca agccgaagaa aagaaagaag cggctccagc agcagcaccc      300

gccgctgccg cagctaagga tgttaacgtg cctgatatcg gctctgacga agtggaagtc      360

accgaaatct tggtcaaggt gggtgataag gtggaagcag aacagtcttt gattacggtt      420

gaaggagata aggctagcat ggaagtgcca gcacccttcg cgggcaccgt taaggaaatc      480

aaagtgaatg tcggcgataa ggtatctacc ggctctctca ttatggtttt cgaagtcgcg      540

ggtgaagcag gagccgccgc accagccgca aagcaagagg cagcaccagc ggcagcacct      600

gctccggctg caggcgtgaa ggaggtaaac gtccctgata ttggtggcga tgaagttgag      660

gtgaccgagg tgatggtgaa agttggagat aaggttgcag ctgaacaatc cttgattact      720

gtggagggtg ataaggcgtc tatggaagtt cccgctccat ttgccggcgt cgtcaaggag      780

cttaaggtga acgttggaga caaggtgaag accggaagcc tcatcatgat tttcgaagtt      840

gagggtgcag cccctgccgc agctccagcc aagcaagagg cagccgctcc cgcgccagcg      900

gcgaaagctg aggctcctgc agcggccccc gccgctaaag ccgaaggcaa atccgaattc      960

gctgagaatg acgcttatgt acacgcaaca cctctgatcc gtcgcctggc acgcgaattt     1020

ggagtcaacc tcgcaaaggt caagggcaca ggccgcaagg gtcgaatcct tcgcgaagac     1080

gttcaagcat atgttaagga agccatcaag cgcgcggaag cggcaccggc agccaccggt     1140

ggtggaatcc ccggcatgtt gccctggccc aaagtggact tctcgaagtt tggcgagatt     1200

gaggaagtgg agctgggtcg catccagaaa atttccggcg caaacctgtc ccgcaactgg     1260

gtcatgattc ctcacgtgac ccatttcgat aaaaccgata ttaccgagtt ggaagcgttt     1320

cgtaaacaac aaaacgaaga agcggctaag cgtaagctcg acgttaaaat tacccccgtt     1380

gtctttatca tgaaggcggt agctgctgct ctcgaacaaa tgccgcgctt caactcttcc     1440

cttagcgagg acggacaacg ccttacattg aagaagtaca tcaatatcgg cgttgctgtc     1500

gatactccca acggcctcgt ggtcccagtg tttaaggatg ttaacaagaa gggtatcatt     1560

gagctcagcc gtgagctgat gacgatcagc aagaaggcac gcgatggtaa gctgaccgcg     1620

ggagaaatgc aaggtggctg cttcactatc tcgtctatcg gaggccttgg aacaacgcac     1680

ttcgcgccga tcgtcaacgc accagaggtg gcgatcctgg gcgtttccaa atctgcgatg     1740

gagcctgtct ggaatggcaa agagttcgta cctcgactta tgcttccaat ttccctgagc     1800

ttcgaccatc gcgtgatcga tggagcagat ggtgcacgct tcattaccat tatcaataac     1860

acgctgtcgg acatccgacg attggttatg                                      1890


<210>  77
<211>  352
<212>  PRT
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  77

Met Ala Ser Glu Lys Glu Ile Arg Arg Glu Arg Phe Leu Asn Val Phe 
1               5                   10                  15      


Pro Lys Leu Val Glu Glu Leu Asn Ala Ser Leu Leu Ala Tyr Gly Met 
            20                  25                  30          


Pro Lys Glu Ala Cys Asp Trp Tyr Ala His Ser Leu Asn Tyr Asn Thr 
        35                  40                  45              


Pro Gly Gly Lys Leu Asn Arg Gly Leu Ser Val Val Asp Thr Tyr Ala 
    50                  55                  60                  


Ile Leu Ser Asn Lys Thr Val Glu Gln Leu Gly Gln Glu Glu Tyr Glu 
65                  70                  75                  80  


Lys Val Ala Ile Leu Gly Trp Cys Ile Glu Leu Leu Gln Ala Tyr Trp 
                85                  90                  95      


Leu Val Ala Asp Asp Met Met Asp Lys Ser Ile Thr Arg Arg Gly Gln 
            100                 105                 110         


Pro Cys Trp Tyr Lys Val Pro Glu Val Gly Glu Ile Ala Ile Trp Asp 
        115                 120                 125             


Ala Phe Met Leu Glu Ala Ala Ile Tyr Lys Leu Leu Lys Ser His Phe 
    130                 135                 140                 


Arg Asn Glu Lys Tyr Tyr Ile Asp Ile Thr Glu Leu Phe His Glu Val 
145                 150                 155                 160 


Thr Phe Gln Thr Glu Leu Gly Gln Leu Met Asp Leu Ile Thr Ala Pro 
                165                 170                 175     


Glu Asp Lys Val Asp Leu Ser Lys Phe Ser Leu Lys Lys His Ser Phe 
            180                 185                 190         


Ile Val Thr Phe Lys Thr Ala Tyr Tyr Ser Phe Tyr Leu Pro Val Ala 
        195                 200                 205             


Leu Ala Met Tyr Val Ala Gly Ile Thr Asp Glu Lys Asp Leu Lys Gln 
    210                 215                 220                 


Ala Arg Asp Val Leu Ile Pro Leu Gly Glu Tyr Phe Gln Ile Gln Asp 
225                 230                 235                 240 


Asp Tyr Leu Asp Cys Phe Gly Thr Pro Glu Gln Ile Gly Lys Ile Gly 
                245                 250                 255     


Thr Asp Ile Gln Asp Asn Lys Cys Ser Trp Val Ile Asn Lys Ala Leu 
            260                 265                 270         


Glu Leu Ala Ser Ala Glu Gln Arg Lys Thr Leu Asp Glu Asn Tyr Gly 
        275                 280                 285             


Lys Lys Asp Ser Val Ala Glu Ala Lys Cys Lys Lys Ile Phe Asn Asp 
    290                 295                 300                 


Leu Lys Ile Glu Gln Leu Tyr His Glu Tyr Glu Glu Ser Ile Ala Lys 
305                 310                 315                 320 


Asp Leu Lys Ala Lys Ile Ser Gln Val Asp Glu Ser Arg Gly Phe Lys 
                325                 330                 335     


Ala Asp Val Leu Thr Ala Phe Leu Asn Lys Val Tyr Lys Arg Ser Lys 
            340                 345                 350         


<210>  78
<211>  1056
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  78
atggcatccg agaaggaaat ccgtcgtgaa cgattcctga acgtattccc aaagctcgtc       60

gaagagctta atgcttcctt gcttgcgtac ggaatgccga aggaagcgtg cgactggtat      120

gcgcattctc tcaactataa cacacctggc ggtaagctga atcgcggtct cagcgtggtg      180

gacacgtacg caatcctcag caataagacc gtggaacagc tgggacagga ggagtacgag      240

aaagttgcta tccttggatg gtgtatcgaa ctgctgcaag cctattggtt ggtagctgat      300

gacatgatgg ataagagcat cactcgacgt ggtcaaccat gctggtacaa ggtgccggag      360

gttggcgaaa tcgcgatctg ggatgcgttc atgttggagg ccgcaattta taagcttctc      420

aagtcccact ttcgtaacga aaagtactat attgacatca cagaactctt tcatgaagtg      480

accttccaaa ccgagctcgg ccaactcatg gatttgatca ccgcccccga agataaggtg      540

gacctttcga agttctccct caagaagcac tcgttcattg ttaccttcaa gacagcatac      600

tactcatttt acctgccagt cgccctcgca atgtacgtgg cgggcatcac tgatgaaaag      660

gatctgaagc aggcccgcga cgtccttatc cctcttggag agtacttcca gatccaggac      720

gattacttgg attgttttgg caccccagag cagattggta aaatcggtac tgatatccaa      780

gacaacaaat gttcctgggt aattaacaag gctctcgagt tggcttccgc ggaacaacgc      840

aagactcttg acgaaaatta cggtaagaaa gattcagtcg ctgaagccaa gtgcaagaaa      900

atctttaacg atcttaaaat cgaacagttg taccacgagt atgaagagtc tatcgctaaa      960

gacctgaaag ctaaaatttc ccaggtcgat gagtcacgcg gcttcaaagc ggatgtgctc     1020

accgccttcc ttaacaaggt gtataagcgc tccaaa                               1056


<210>  79
<211>  299
<212>  PRT
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  79

Met Asp Phe Pro Gln Gln Leu Glu Ala Cys Val Lys Gln Ala Asn Gln 
1               5                   10                  15      


Ala Leu Ser Arg Phe Ile Ala Pro Leu Pro Phe Gln Asn Thr Pro Val 
            20                  25                  30          


Val Glu Thr Met Gln Tyr Gly Ala Leu Leu Gly Gly Lys Arg Leu Arg 
        35                  40                  45              


Pro Phe Leu Val Tyr Ala Thr Gly His Met Phe Gly Val Ser Thr Asn 
    50                  55                  60                  


Thr Leu Asp Ala Pro Ala Ala Ala Val Glu Cys Ile His Ala Tyr Phe 
65                  70                  75                  80  


Leu Ile His Asp Asp Leu Pro Ala Met Asp Asp Asp Asp Leu Arg Arg 
                85                  90                  95      


Gly Leu Pro Thr Cys His Val Lys Phe Gly Glu Ala Asn Ala Ile Leu 
            100                 105                 110         


Ala Gly Asp Ala Leu Gln Thr Leu Ala Phe Ser Ile Leu Ser Asp Ala 
        115                 120                 125             


Asp Met Pro Glu Val Ser Asp Arg Asp Arg Ile Ser Met Ile Ser Glu 
    130                 135                 140                 


Leu Ala Ser Ala Ser Gly Ile Ala Gly Met Cys Gly Gly Gln Ala Leu 
145                 150                 155                 160 


Asp Leu Asp Ala Glu Gly Lys His Val Pro Leu Asp Ala Leu Glu Arg 
                165                 170                 175     


Ile His Arg His Lys Thr Gly Ala Leu Ile Arg Ala Ala Val Arg Leu 
            180                 185                 190         


Gly Ala Leu Ser Ala Gly Asp Lys Gly Arg Arg Ala Leu Pro Val Leu 
        195                 200                 205             


Asp Lys Tyr Ala Glu Ser Ile Gly Leu Ala Phe Gln Val Gln Asp Asp 
    210                 215                 220                 


Ile Leu Asp Val Val Gly Asp Thr Ala Thr Leu Gly Lys Arg Gln Gly 
225                 230                 235                 240 


Ala Asp Gln Gln Leu Gly Lys Ser Thr Tyr Pro Ala Leu Leu Gly Leu 
                245                 250                 255     


Glu Gln Ala Arg Lys Lys Ala Arg Asp Leu Ile Asp Asp Ala Arg Gln 
            260                 265                 270         


Ser Leu Lys Gln Leu Ala Glu Gln Ser Leu Asp Thr Ser Ala Leu Glu 
        275                 280                 285             


Ala Leu Ala Asp Tyr Ile Ile Gln Arg Asn Lys 
    290                 295                 


<210>  80
<211>  897
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  80
atggacttcc cgcagcagct cgaggcctgc gttaagcagg ccaatcaggc gttgtcacgt       60

ttcatcgctc ccctgccttt ccagaacaca ccagtagtgg aaaccatgca atacggcgcc      120

ctgctgggtg gaaaacgctt gcgcccattc ttggtgtacg caaccggcca catgttcggc      180

gtctctacta acacccttga tgcacctgca gcggccgtgg agtgtatcca cgcctacttc      240

ttgatccacg acgatttgcc ggctatggat gatgatgatc tccgacgagg cctccctacc      300

tgccatgtaa aattcggcga agcgaatgcg atcttggcag gtgatgcgct gcagacactt      360

gccttttcga ttctgagcga cgcggatatg ccggaagtct ccgaccgaga ccgcatctcc      420

atgatcagcg agttggcttc tgcctccggt atcgcgggca tgtgcggagg tcaggctctt      480

gaccttgacg cagagggcaa gcacgttccc ttggacgctt tggagcgtat ccaccgccat      540

aagaccggcg ccttgatccg cgccgcggtc cgcttgggcg cgctgtctgc gggcgataag      600

ggacgccgcg cactcccagt gctcgataag tacgccgaat ccattggcct tgcttttcag      660

gtgcaggatg acatccttga tgtagtcggc gataccgcaa ctctcggcaa acgccagggc      720

gcggaccaac aattgggtaa gtcaacctac ccagctctgc tgggcttgga gcaagcacga      780

aagaaagccc gcgacctgat cgacgatgcc cgccaatctc ttaaacaact ggccgaacaa      840

tctctcgata ccagcgcact cgaggcactc gcagattaca tcatccaacg taataag         897


<210>  81
<211>  474
<212>  PRT
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  81

Met Ser Thr Glu Ile Lys Thr Gln Val Val Val Leu Gly Ala Gly Pro 
1               5                   10                  15      


Ala Gly Tyr Ser Ala Ala Phe Arg Cys Ala Asp Leu Gly Leu Glu Thr 
            20                  25                  30          


Val Ile Val Glu Arg Tyr Asn Thr Leu Gly Gly Val Cys Leu Asn Val 
        35                  40                  45              


Gly Cys Ile Pro Ser Lys Ala Leu Leu His Val Ala Lys Val Ile Glu 
    50                  55                  60                  


Glu Ala Lys Ala Leu Ala Glu His Gly Ile Val Phe Gly Glu Pro Lys 
65                  70                  75                  80  


Thr Asp Ile Asp Lys Ile Arg Thr Trp Lys Glu Lys Val Ile Asn Gln 
                85                  90                  95      


Leu Thr Gly Gly Leu Ala Gly Met Ala Lys Gly Arg Lys Val Lys Val 
            100                 105                 110         


Val Asn Gly Leu Gly Lys Phe Thr Gly Ala Asn Thr Leu Glu Val Glu 
        115                 120                 125             


Gly Glu Asn Gly Lys Thr Val Ile Asn Phe Asp Asn Ala Ile Ile Ala 
    130                 135                 140                 


Ala Gly Ser Arg Pro Ile Gln Leu Pro Phe Ile Pro His Glu Asp Pro 
145                 150                 155                 160 


Arg Ile Trp Asp Ser Thr Asp Ala Leu Glu Leu Lys Glu Val Pro Glu 
                165                 170                 175     


Arg Leu Leu Val Met Gly Gly Gly Ile Ile Ala Leu Glu Met Ala Thr 
            180                 185                 190         


Val Tyr His Ala Leu Gly Ser Gln Ile Asp Val Val Val Arg Lys His 
        195                 200                 205             


Gln Val Ile Arg Ala Ala Asp Lys Asp Ile Val Lys Val Phe Thr Lys 
    210                 215                 220                 


Arg Ile Ser Lys Lys Phe Asn Leu Met Leu Glu Thr Lys Val Thr Ala 
225                 230                 235                 240 


Val Glu Ala Lys Glu Asp Gly Ile Tyr Val Thr Met Glu Gly Lys Lys 
                245                 250                 255     


Ala Pro Ala Glu Pro Gln Arg Tyr Asp Ala Val Leu Val Ala Ile Gly 
            260                 265                 270         


Arg Val Pro Asn Gly Lys Asn Leu Asp Ala Gly Lys Ala Gly Val Glu 
        275                 280                 285             


Val Asp Asp Arg Gly Phe Ile Arg Val Asp Lys Gln Leu Arg Thr Asn 
    290                 295                 300                 


Val Pro His Ile Phe Ala Ile Gly Asp Ile Val Gly Gln Pro Met Leu 
305                 310                 315                 320 


Ala His Lys Gly Val His Glu Gly His Val Ala Ala Glu Val Ile Ala 
                325                 330                 335     


Gly Lys Lys His Tyr Phe Asp Pro Lys Val Ile Pro Ser Ile Ala Tyr 
            340                 345                 350         


Thr Glu Pro Glu Val Ala Trp Val Gly Leu Thr Glu Lys Glu Ala Lys 
        355                 360                 365             


Glu Lys Gly Ile Ser Tyr Glu Thr Ala Thr Phe Pro Trp Ala Ala Ser 
    370                 375                 380                 


Gly Arg Ala Ile Ala Ser Asp Cys Ala Asp Gly Met Thr Lys Leu Ile 
385                 390                 395                 400 


Phe Asp Lys Glu Ser His Arg Val Ile Gly Gly Ala Ile Val Gly Thr 
                405                 410                 415     


Asn Gly Gly Glu Leu Leu Gly Glu Ile Gly Leu Ala Ile Glu Met Gly 
            420                 425                 430         


Cys Asp Ala Glu Asp Ile Ala Leu Thr Ile His Ala His Pro Thr Leu 
        435                 440                 445             


His Glu Ser Val Gly Leu Ala Ala Glu Val Phe Glu Gly Ser Ile Thr 
    450                 455                 460                 


Asp Leu Pro Asn Pro Lys Ala Lys Lys Lys 
465                 470                 


<210>  82
<211>  1422
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  82
atgtcgactg agatcaagac ccaagtcgta gtcctgggcg caggccctgc cggatactcc       60

gccgcgttcc gctgcgcgga cctcggtctt gaaaccgtga ttgtcgaacg ttacaacaca      120

ctgggcggtg tatgccttaa cgtgggctgc atcccctcca aagcactgtt gcacgttgcg      180

aaggtgattg aagaggcaaa ggcgctcgcg gaacacggca tcgtcttcgg cgaacctaag      240

actgacatcg ataaaattcg aacttggaag gaaaaagtga ttaaccagct taccggagga      300

ctggcaggta tggcaaaggg ccgaaaagtc aaagtggtga atggtttggg taagttcacc      360

ggcgccaaca ccctggaagt ggagggcgaa aacggcaaaa cggtcattaa tttcgacaac      420

gcaattattg cagcaggttc gcgccctatc cagctgccct tcattccaca tgaggacccc      480

cgtatctggg atagcacaga cgcactggaa ctcaaggaag tcccagaacg tctgctggtg      540

atgggtggcg gtattatcgc actcgaaatg gccacagtct accacgcgtt gggttctcag      600

atcgatgtgg ttgtacgcaa gcaccaagtg atccgcgccg cggacaaaga tatcgttaag      660

gtatttacca agcgcatttc aaagaagttc aacttgatgc tcgaaaccaa ggttaccgct      720

gttgaagcta aggaagacgg aatctacgtg accatggaag gaaagaaggc tcccgcagag      780

ccacagcgct acgatgcagt gcttgttgca attggacgcg tgcctaacgg caaaaatctc      840

gatgccggta aagctggcgt agaggtagat gaccgtggtt ttatccgcgt tgataagcaa      900

ttgcgaacga atgtgccaca catttttgct atcggtgaca ttgtgggtca accgatgctt      960

gcccacaagg gcgtccacga aggccacgtg gccgccgagg ttatcgccgg taagaaacac     1020

tactttgatc caaaagttat cccgtccatt gcctacactg aaccggaagt ggcatgggtg     1080

ggcttgaccg aaaaagaagc aaaagaaaag ggcattagct atgaaacagc aacctttccg     1140

tgggccgcat ccggccgcgc cattgcgagc gactgcgcgg acggcatgac taaattgatt     1200

tttgacaagg aaagccatcg cgtgatcgga ggtgcaatcg tgggtaccaa cggtggcgag     1260

ttgttgggtg agatcggcct cgctatcgaa atgggctgcg acgccgaaga tatcgctctg     1320

accattcacg cacacccaac cctgcatgaa tctgttggcc tggctgcgga ggtcttcgag     1380

ggctccatca ccgatctccc aaatccaaaa gcaaagaaaa aa                        1422


<210>  83
<211>  474
<212>  PRT
<213>  E. coli ATCC 9637

<400>  83

Met Ser Thr Glu Ile Lys Thr Gln Val Val Val Leu Gly Ala Gly Pro 
1               5                   10                  15      


Ala Gly Tyr Ser Ala Ala Phe Arg Cys Ala Asp Leu Gly Leu Glu Thr 
            20                  25                  30          


Val Ile Val Glu Arg Tyr Asn Thr Leu Gly Gly Val Cys Leu Asn Val 
        35                  40                  45              


Gly Cys Ile Pro Ser Lys Ala Leu Leu His Val Ala Lys Val Ile Glu 
    50                  55                  60                  


Glu Ala Lys Ala Leu Ala Glu His Gly Ile Val Phe Gly Glu Pro Lys 
65                  70                  75                  80  


Thr Asp Ile Asp Lys Ile Arg Thr Trp Lys Glu Lys Val Ile Asn Gln 
                85                  90                  95      


Leu Thr Gly Gly Leu Ala Gly Met Ala Lys Gly Arg Lys Val Lys Val 
            100                 105                 110         


Val Asn Gly Leu Gly Lys Phe Thr Gly Ala Asn Thr Leu Glu Val Glu 
        115                 120                 125             


Gly Glu Asn Gly Lys Thr Val Ile Asn Phe Asp Asn Ala Ile Ile Ala 
    130                 135                 140                 


Ala Gly Ser Arg Pro Ile Gln Leu Pro Phe Ile Pro His Glu Asp Pro 
145                 150                 155                 160 


Arg Ile Trp Asp Ser Thr Asp Ala Leu Glu Leu Lys Glu Val Pro Glu 
                165                 170                 175     


Arg Leu Leu Val Met Gly Gly Gly Ile Ile Gly Leu Glu Met Gly Thr 
            180                 185                 190         


Val Tyr His Ala Leu Gly Ser Gln Ile Asp Val Val Glu Met Phe Asp 
        195                 200                 205             


Gln Val Ile Pro Ala Ala Asp Lys Asp Ile Val Lys Val Phe Thr Lys 
    210                 215                 220                 


Arg Ile Ser Lys Lys Phe Asn Leu Met Leu Glu Thr Lys Val Thr Ala 
225                 230                 235                 240 


Val Glu Ala Lys Glu Asp Gly Ile Tyr Val Thr Met Glu Gly Lys Lys 
                245                 250                 255     


Ala Pro Ala Glu Pro Gln Arg Tyr Asp Ala Val Leu Val Ala Ile Gly 
            260                 265                 270         


Arg Val Pro Asn Gly Lys Asn Leu Asp Ala Gly Lys Ala Gly Val Glu 
        275                 280                 285             


Val Asp Asp Arg Gly Phe Ile Arg Val Asp Lys Gln Leu Arg Thr Asn 
    290                 295                 300                 


Val Pro His Ile Phe Ala Ile Gly Asp Ile Val Gly Gln Pro Met Leu 
305                 310                 315                 320 


Ala His Lys Gly Val His Glu Gly His Val Ala Ala Glu Val Ile Ala 
                325                 330                 335     


Gly Lys Lys His Tyr Phe Asp Pro Lys Val Ile Pro Ser Ile Ala Tyr 
            340                 345                 350         


Thr Glu Pro Glu Val Ala Trp Val Gly Leu Thr Glu Lys Glu Ala Lys 
        355                 360                 365             


Glu Lys Gly Ile Ser Tyr Glu Thr Ala Thr Phe Pro Trp Ala Ala Ser 
    370                 375                 380                 


Gly Arg Ala Ile Ala Ser Asp Cys Ala Asp Gly Met Thr Lys Leu Ile 
385                 390                 395                 400 


Phe Asp Lys Glu Ser His Arg Val Ile Gly Gly Ala Ile Val Gly Thr 
                405                 410                 415     


Asn Gly Gly Glu Leu Leu Gly Glu Ile Gly Leu Ala Ile Glu Met Gly 
            420                 425                 430         


Cys Asp Ala Glu Asp Ile Ala Leu Thr Ile His Ala His Pro Thr Leu 
        435                 440                 445             


His Glu Ser Val Gly Leu Ala Ala Glu Val Phe Glu Gly Ser Ile Thr 
    450                 455                 460                 


Asp Leu Pro Asn Pro Lys Ala Lys Lys Lys 
465                 470                 


<210>  84
<211>  1422
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  84
atgtcaactg agattaaaac tcaggtggtc gttctgggcg ccggaccagc tggctattca       60

gcagcgtttc gctgcgcaga tctgggcctg gagacagtaa tcgttgagcg ttataacacc      120

cttggcggtg tctgcctgaa cgtcggatgc atcccttcta aggccctgct gcacgtggca      180

aaagtcatcg aagaagcgaa ggctcttgcc gaacacggca tcgtgtttgg agaaccaaag      240

actgacatcg acaagatccg cacatggaaa gagaaggtga tcaaccaact caccggtggt      300

ttggccggta tggcaaaggg tcgcaaagtt aaggtagtca atggccttgg caaatttacc      360

ggcgcaaaca ctcttgaagt ggaaggtgag aacggaaaga ctgtgatcaa cttcgacaac      420

gcaatcatcg cagccggctc gcgtcctatt caactgccgt tcatcccaca cgaagatccg      480

cgtatctggg atagcaccga tgcgctggag ctgaaagaag taccggaacg attgctcgtc      540

atgggtggag gtatcatcgg cttggagatg ggaaccgtat accacgcact tggctcccag      600

atcgacgttg tcgaaatgtt cgatcaggtg attccagcag cagataagga tatcgtgaag      660

gtgttcacca agcgcatttc aaagaagttc aatctgatgt tggaaaccaa ggttacggca      720

gtggaagcaa aggaggatgg tatctacgtg actatggagg gtaaaaaagc accagcggaa      780

ccccagcgat acgacgcagt tctcgtcgct atcggacgcg tcccaaatgg taagaatctg      840

gacgctggca aagcaggcgt cgaagtggat gaccgtggct tcatccgcgt agataaacag      900

ttgcgcacaa atgttccaca catctttgca attggagaca tcgtaggcca gcccatgctg      960

gcccacaaag gtgtccatga aggtcacgtg gcggctgagg ttatcgcagg caagaagcac     1020

tacttcgatc caaaggtgat ccccagcatt gcctatacgg agccagaggt agcttgggtt     1080

ggtttgaccg aaaaagaggc aaaggagaag ggtatctcgt atgaaacagc aacctttcca     1140

tgggccgcgt ccggacgtgc tatcgcaagc gactgcgcag atggcatgac caagctgatc     1200

ttcgacaaag aatcccaccg cgtgatcggt ggtgctattg ttggcactaa cggcggcgaa     1260

ctcttgggcg aaatcggctt ggcaattgaa atgggctgcg atgctgagga catcgctttg     1320

accatccacg cacacccgac cctgcatgag tctgtgggac tggcagccga agtgttcgaa     1380

ggctcaatca ccgacctccc taatcccaag gctaagaaga aa                        1422


<210>  85
<211>  299
<212>  PRT
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  85

Met Asp Phe Pro Gln Gln Leu Glu Ala Cys Val Lys Gln Ala Asn Gln 
1               5                   10                  15      


Ala Leu Ser Arg Phe Ile Ala Pro Leu Pro Phe Gln Asn Thr Pro Val 
            20                  25                  30          


Val Glu Thr Met Gln Tyr Gly Ala Leu Leu Gly Gly Lys Arg Leu Arg 
        35                  40                  45              


Pro Phe Leu Val Tyr Ala Thr Gly His Met Phe Gly Val Ser Thr Asn 
    50                  55                  60                  


Thr Leu Asp Ala Pro Ala Ala Ala Val Glu Cys Ile His Ala Tyr Phe 
65                  70                  75                  80  


Leu Ile His Asp Asp Leu Pro Ala Met Asp Asp Asp Asp Leu Arg Arg 
                85                  90                  95      


Gly Leu Pro Thr Cys His Val Lys Phe Gly Glu Ala Asn Ala Ile Leu 
            100                 105                 110         


Ala Gly Asp Ala Leu Gln Thr Leu Ala Phe Ser Ile Leu Ser Asp Ala 
        115                 120                 125             


Asp Met Pro Glu Val Ser Asp Arg Asp Arg Ile Ser Met Ile Ser Glu 
    130                 135                 140                 


Leu Ala Ser Ala Ser Gly Ile Ala Gly Met Cys Gly Gly Gln Ala Leu 
145                 150                 155                 160 


Asp Leu Asp Ala Glu Gly Lys His Val Pro Leu Asp Ala Leu Glu Arg 
                165                 170                 175     


Ile His Arg His Lys Thr Gly Ala Leu Ile Arg Ala Ala Val Arg Leu 
            180                 185                 190         


Gly Ala Leu Ser Ala Gly Asp Lys Gly Arg Arg Ala Leu Pro Val Leu 
        195                 200                 205             


Asp Lys Tyr Ala Glu Ser Ile Gly Leu Ala Phe Gln Val Gln Asp Asp 
    210                 215                 220                 


Ile Leu Asp Val Val Gly Asp Thr Ala Thr Leu Gly Lys Arg Gln Gly 
225                 230                 235                 240 


Ala Asp Gln Gln Leu Gly Lys Ser Thr Tyr Pro Ala Leu Leu Gly Leu 
                245                 250                 255     


Glu Gln Ala Arg Lys Lys Ala Arg Asp Leu Ile Asp Asp Ala Arg Gln 
            260                 265                 270         


Ser Leu Lys Gln Leu Ala Glu Gln Ser Leu Asp Thr Ser Ala Leu Glu 
        275                 280                 285             


Ala Leu Ala Asp Tyr Ile Ile Gln Arg Asn Lys 
    290                 295                 


<210>  86
<211>  897
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  86
atggacttcc cgcaacagct tgaagcgtgt gtgaaacagg ccaaccaagc cctttcacgg       60

ttcattgccc cgcttccgtt ccaaaatacg ccggttgtag agacgatgca atacggcgcc      120

ctgcttggtg gtaaacggtt acgccctttc ctcgtgtacg caacaggaca tatgtttggt      180

gtcagcacaa atacactgga cgctccagcg gcggctgtgg aatgtatcca tgcatacttt      240

ttaattcacg atgacttgcc tgcaatggac gatgacgact taagacgtgg gctcccgacg      300

tgccacgtaa aatttggcga agctaacgcc attctggcgg gagacgcgct tcaaacgctc      360

gcctttagca tcctgtccga tgctgatatg ccggaggtat cggatcgcga tcgcattagt      420

atgatctcag aattggccag cgcttcaggg attgccggca tgtgtggcgg gcaggcgtta      480

gacttggacg cggagggcaa acacgtccct ttagatgcgc ttgagagaat acatagacat      540

aagacagggg cgcttatcag agcagctgta agacttggcg cgctgtctgc gggcgataaa      600

ggaagacggg ccctgccggt tttagataag tatgcagaat cgatcggact ggcgttccaa      660

gtgcaggacg acatccttga tgtcgttggt gataccgcga cacttgggaa aagacagggc      720

gcggatcaac agcttggcaa atccacctat ccggctttgc tcgggctgga gcaagcgcga      780

aaaaaagcta gagacttaat tgatgatgcc cgccagagct taaagcaact cgcggagcaa      840

tcgctggata catcagcact ggaagctctg gctgactata ttatccaacg taacaag         897


<210>  87
<211>  897
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  87
atggatttcc cacaacaatt ggaggcctgc gttaagcagg cgaaccaagc tctttcgcga       60

ttcatcgcgc cactcccgtt tcaaaacacg ccagtggtcg aaactatgca atacggcgct      120

ttgcttggtg gaaagcgttt gcgccccttc cttgtttacg caaccggtca catgtttggt      180

gtctctacta acacacttga tgcccccgcg gcggccgtgg agtgtatcca cgcttacttc      240

ctcattcacg atgacctccc tgcgatggac gatgatgacc tgcgtcgtgg cctgcccacc      300

tgtcacgtga aatttggtga agctaacgcc atcctggctg gcgacgcact gcagaccctt      360

gccttctcca ttctgagcga cgcagacatg cctgaagtct ccgaccgtga tcgcatctcg      420

atgatttccg agctcgcgtc cgccagcggc attgccggta tgtgcggtgg tcaggccctt      480

gacctggatg ctgaaggcaa acacgtgccg cttgatgctc tcgaacgcat ccaccgacac      540

aagaccggcg cgctgattcg tgctgccgtg cgcctcggcg ctttgtccgc aggtgacaaa      600

ggacgccgcg ctctcccagt attggataaa tatgccgaat ccattggtct cgccttccaa      660

gtgcaagacg atatcctcga cgtggtgggc gataccgcga cccttggaaa gcgtcaaggt      720

gcggaccagc agctgggaaa gtccacttat cccgcactcc tcggtttgga gcaggcacgc      780

aagaaggccc gcgacctgat tgatgacgcg cgtcaatcac tgaaacaact cgcagagcaa      840

tccctggata catctgccct ggaggccctg gcagactaca tcatccaacg taacaag         897


<210>  88
<211>  897
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  88
atggactttc cacaacagct ggaagcatgc gtgaagcagg ctaaccaggc tctatcaaga       60

ttcatcgcgc ccttaccttt ccaaaatacg cctgttgtgg aaactatgca gtatggggca      120

ttattgggtg gtaaaaggtt aaggccgttt ttagtgtatg ctacggggca catgttcggt      180

gtcagtacaa atacacttga cgcacctgca gcggctgttg aatgtattca tgcttatttt      240

ttaatccatg atgatttacc tgcaatggat gatgatgatt tgcgtagagg cctaccaaca      300

tgtcatgtga aatttggtga agcaaatgct attctagctg gggacgcttt gcaaacttta      360

gcgttcagca tcttgtccga tgcagatatg cctgaagtta gcgatagaga tagaattagt      420

atgatctcag aattagcatc cgcttctgga atcgctggca tgtgtggtgg ccaagcgctg      480

gatttggatg ctgaaggaaa acacgtaccg ttggatgcct tggaaagaat tcataggcat      540

aaaacgggtg cattgattcg tgctgctgtg cgtcttggtg ctctgtctgc gggagacaag      600

ggtagaaggg cgttgccagt tttggataaa tatgctgaaa gcattgggtt agcgtttcaa      660

gttcaagatg acatcttgga tgtggttgga gacacagcca ctttaggtaa aagacaagga      720

gcagaccagc aattaggcaa atctacttac cctgcattgt tgggtttaga gcaggctcgt      780

aagaaggcta gagacttgat agacgatgct agacagtcat tgaagcaatt ggccgaacag      840

agccttgata cgagcgccct tgaagcctta gctgattaca ttatccaaag aaataaa         897


<210>  89
<211>  897
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  89
atggactttc ctcagcaact ggaggcctgc gtgaagcagg ctaaccaggc actgagccgg       60

tttatcgccc cccttccctt tcaaaacact cctgtcgtcg agacgatgca atacggtgct      120

cttctcggtg gtaagcgact ccgacccttc ctcgtttacg ctacaggcca tatgtttgga      180

gtctccacca ataccctcga cgccccagct gccgccgtcg aatgcatcca tgcttacttc      240

ctgatccacg acgacctgcc cgctatggac gacgatgacc tgcgacgagg actccccact      300

tgtcatgtca aattcggcga ggctaacgcc attctggctg gagacgccct ccagactctc      360

gctttctcta tcctctccga cgctgacatg cctgaagtct ctgatcgaga ccggatttcc      420

atgatttccg agctggcctc ggcctccggc attgccggaa tgtgtggtgg tcaggctctc      480

gacctggacg ctgagggcaa gcatgtgccc ctcgacgccc ttgagcggat tcatcggcac      540

aagacgggcg ctctcatccg agctgccgtt cggctcggag ctctgtctgc cggagacaag      600

ggtcgacggg ctctccccgt ccttgataag tacgctgagt ccattggcct ggcctttcaa      660

gttcaggatg atattctcga cgtcgtcggt gatacggcca cccttggcaa gcgacaaggt      720

gctgaccagc agctgggcaa gtcgacctac cctgccctgc tcggactcga acaggcccga      780

aagaaggcac gtgatctgat cgacgacgca cgacagagcc tgaaacaact ggccgagcag      840

tctcttgaca cctccgccct ggaggctctc gccgactaca ttattcagcg aaacaag         897


<210>  90
<211>  1056
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  90
atggcatctg agaaggagat cagaagagaa cgctttttaa acgtgtttcc gaaactggta       60

gaagagttaa atgcgagcct gcttgcgtac ggcatgccaa aggaagcatg tgattggtat      120

gcacacagct taaattataa tacaccggga ggtaagctta acagagggct ttctgtagtg      180

gacacgtatg ctatattaag taataaaaca gtggaacaac ttggccaaga agaatatgaa      240

aaggtggcca tcctggggtg gtgcattgag cttttacaag catattggct tgtggcggat      300

gatatgatgg acaagtcaat tacacgtcgt ggtcagccgt gctggtataa ggtaccggaa      360

gttggggaaa tagctatctg ggacgcattt atgcttgaag ctgctattta taaacttctt      420

aaaagccatt tccgtaatga aaagtattac attgacatta ccgaactttt tcatgaggta      480

acatttcaaa ccgaactggg gcagcttatg gacttgatta cagcaccgga ggacaaagtt      540

gatctgtcga aattctcact taaaaaacat tcttttattg taacgttcaa gactgcgtat      600

tattcatttt atctgccggt cgcgcttgca atgtatgtag ccggcattac agatgaaaag      660

gacttaaaac aggctcggga tgttctgatt ccattggggg aatatttcca aattcaggat      720

gactatctgg actgttttgg taccccggaa cagattggta aaatcggcac agatatccaa      780

gataataaat gctcctgggt tatcaataaa gcactggaac tggctagcgc tgaacaaaga      840

aagactttgg atgaaaacta cggcaagaaa gatagcgtcg ctgaagctaa gtgcaaaaaa      900

atttttaacg acttaaaaat cgagcaactg taccacgaat atgaagaaag tattgctaaa      960

gatctcaaag ctaaaataag ccaggtggat gaatctcgcg ggttcaaagc agatgtattg     1020

acagcgtttc ttaataaagt gtataaacga tccaaa                               1056


<210>  91
<211>  1056
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  91
atggctagcg aaaaggagat ccgaagagag agattcctca acgtgttccc taaacttgtg       60

gaggagctca acgcttcgct cctcgcttac ggtatgccca aggaggcctg tgattggtat      120

gcacactccc ttaactacaa cacgcctggt ggtaagctca accgaggtct ttctgttgtc      180

gatacctatg caattctttc caacaagacc gtcgagcaac tgggtcagga ggagtacgag      240

aaagtggcaa ttcttggctg gtgcattgaa ctcctccaag cttactggct ggtggctgat      300

gacatgatgg acaagagcat cacccgacga ggtcagccct gctggtacaa ggtgccagag      360

gttggagaga tcgccatttg ggacgcattt atgctggagg ctgccattta caagctcctt      420

aagtctcact ttcgaaacga gaagtactac atcgacatta ctgagctctt tcacgaagtg      480

acttttcaga ctgagctggg tcagcttatg gatctcatta ccgctcccga ggataaagtg      540

gatctgtcga agttttccct caagaagcat tcgtttattg tcaccttcaa gacagcatac      600

tactcttttt acctgcccgt cgccctcgca atgtacgtcg caggaattac cgatgagaaa      660

gacctcaagc aggcacgtga cgtcctcatc cccctcggcg agtactttca gattcaggat      720

gactatctcg actgcttcgg taccccagag caaatcggaa agattggaac tgacatccag      780

gacaataagt gctcttgggt tattaacaag gcccttgagc tggcttccgc cgagcaacga      840

aagacccttg acgagaatta cggcaagaag gatagcgtgg ccgaggccaa gtgcaagaag      900

atcttcaacg acctcaagat cgagcagctc taccacgagt acgaggagtc gattgctaag      960

gaccttaagg ctaagattag ccaggtggac gagtcccggg gattcaaggc tgacgtcctg     1020

accgcctttc tcaacaaggt ctacaagcga tccaag                               1056


<210>  92
<211>  603
<212>  PRT
<213>  Perilla setoyensis

<400>  92

Met Cys Ser Ile Ser Gln Lys Val Val Ile Gly Leu Asn Lys Ala Ala 
1               5                   10                  15      


Ala Asn Asn Cys Leu Gln Asn Leu Asp Arg Arg Gly Phe Lys Thr Arg 
            20                  25                  30          


Arg Val Ser Ser Ser Glu Ala Ala Ser Cys Leu Arg Ala Ser Ser Ser 
        35                  40                  45              


Leu Gln Leu Asp Val Lys Pro Val Glu Glu Gly Arg Arg Ser Gly Asn 
    50                  55                  60                  


Tyr Gln Pro Ser Ile Trp Asp Phe Asn Tyr Val Gln Ser Leu Asn Thr 
65                  70                  75                  80  


Pro Tyr Lys Glu Glu Arg Tyr Leu Thr Arg His Ala Glu Leu Ile Val 
                85                  90                  95      


Gln Val Lys Pro Leu Leu Glu Lys Lys Met Glu Ala Thr Gln Gln Leu 
            100                 105                 110         


Glu Leu Ile Asp Asp Leu Asn Asn Leu Gly Leu Ser Tyr Phe Phe Gln 
        115                 120                 125             


Asp Arg Ile Lys Gln Ile Leu Ser Phe Ile Tyr Asp Glu Asn Gln Cys 
    130                 135                 140                 


Phe His Ser Asn Ile Asn Asp Gln Ala Glu Lys Arg Asp Leu Tyr Phe 
145                 150                 155                 160 


Thr Ala Leu Gly Phe Arg Leu Leu Arg Gln His Gly Phe Asn Val Ser 
                165                 170                 175     


Gln Glu Val Phe Asp Cys Phe Lys Asn Asp Lys Gly Ser Asp Phe Lys 
            180                 185                 190         


Ala Ser Leu Ser Gly Asn Thr Lys Gly Leu Leu Gln Leu Tyr Glu Ala 
        195                 200                 205             


Ser Phe Leu Val Arg Glu Gly Glu Asp Thr Leu Glu Leu Ala Arg Gln 
    210                 215                 220                 


Phe Ala Thr Lys Phe Leu Arg Arg Lys Leu Asp Glu Ile Asp Asp Asn 
225                 230                 235                 240 


His Leu Leu Ser Arg Ile His His Ser Leu Glu Ile Pro Leu His Trp 
                245                 250                 255     


Arg Ile Gln Arg Leu Glu Ala Arg Trp Phe Leu Asp Ala Tyr Ala Thr 
            260                 265                 270         


Arg His Asp Met Asn Pro Ile Ile Leu Glu Leu Ala Lys Leu Asp Phe 
        275                 280                 285             


Asn Ile Ile Gln Ala Thr His Gln Glu Glu Leu Lys Asp Val Ser Arg 
    290                 295                 300                 


Trp Trp Gln Asn Thr Arg Leu Ala Glu Lys Leu Pro Phe Val Arg Asp 
305                 310                 315                 320 


Arg Leu Val Glu Ser Tyr Phe Trp Ala Ile Ala Leu Phe Glu Pro His 
                325                 330                 335     


Gln Tyr Gly Tyr Gln Arg Arg Val Ala Ala Lys Ile Ile Thr Leu Ala 
            340                 345                 350         


Thr Ser Ile Asp Asp Val Tyr Asp Ile Tyr Gly Thr Leu Asp Glu Leu 
        355                 360                 365             


Gln Leu Phe Thr Asp Asn Phe Arg Arg Trp Asp Thr Glu Ser Leu Gly 
    370                 375                 380                 


Gly Leu Pro Tyr Ser Met Gln Leu Phe Tyr Met Val Ile His Asn Phe 
385                 390                 395                 400 


Val Ser Glu Leu Ala Tyr Glu Ile Leu Lys Glu Lys Gly Phe Ile Ala 
                405                 410                 415     


Ile Pro Tyr Leu Gln Arg Ser Trp Val Asp Leu Ala Glu Ser Phe Leu 
            420                 425                 430         


Lys Glu Ala Asn Trp Tyr Tyr Ser Gly Tyr Thr Pro Ser Leu Glu Glu 
        435                 440                 445             


Tyr Ile Asp Asn Gly Ser Ile Ser Ile Gly Ala Val Ala Val Leu Ser 
    450                 455                 460                 


Gln Val Tyr Phe Thr Leu Ala Asn Ser Ile Glu Lys Pro Lys Ile Glu 
465                 470                 475                 480 


Ser Met Tyr Lys Tyr His His Ile Leu Arg Leu Ser Gly Leu Leu Val 
                485                 490                 495     


Arg Leu His Asp Asp Leu Gly Thr Ser Leu Phe Glu Lys Lys Arg Gly 
            500                 505                 510         


Asp Val Pro Lys Ala Val Glu Ile Cys Met Lys Glu Arg Asn Asp Thr 
        515                 520                 525             


Glu Glu Glu Ala Glu Glu His Val Lys Tyr Leu Ile Arg Glu Ala Trp 
    530                 535                 540                 


Lys Glu Met Asn Thr Ala Thr Ala Ala Ala Gly Cys Pro Phe Met Asp 
545                 550                 555                 560 


Glu Leu Asn Val Ala Ala Ala Asn Leu Gly Arg Ala Ala Gln Phe Val 
                565                 570                 575     


Tyr Leu Asp Gly Asp Gly His Gly Val Gln His Ser Lys Ile His Gln 
            580                 585                 590         


Gln Met Gly Gly Leu Met Phe Lys Pro Tyr Val 
        595                 600             


<210>  93
<211>  1809
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  93
atgtgcagca tctctcaaaa ggtcgttatt ggattgaata aggcagcggc caataactgc       60

ctccaaaacc ttgatcgccg aggttttaaa acacgccgtg tttcatcctc cgaagcggct      120

tcttgcctcc gagcctcaag ctcgctgcag cttgatgtca agccggtgga ggaaggccga      180

cgttccggta actatcagcc atcaatctgg gattttaatt atgtccagtc cctcaacacc      240

ccctacaaag aggaacgtta ccttacccga cacgcggaac tcatcgttca ggtcaagccg      300

cttctcgaaa aaaagatgga ggctactcag cagttggagc tcatcgatga ccttaacaac      360

ctcggtctga gctacttttt ccaagaccgc atcaagcaga ttctctcatt catctatgat      420

gaaaatcagt gtttccactc caatatcaat gatcaagctg aaaagcgaga cctgtacttt      480

accgcccttg gatttcgtct ccttcgccag cacggcttta acgtgtctca ggaggtgttc      540

gattgcttca aaaacgataa aggctccgat tttaaagcgt ccctgtctgg aaacaccaag      600

ggcctcctcc agctctacga agcctccttc ttggtccgtg agggtgaaga caccctcgaa      660

ctggcccgtc agttcgcgac caagttcctg cgccgcaagc ttgacgaaat cgacgacaac      720

catctgctct cacgaattca ccactcactc gaaatcccgt tgcactggcg catccagcgt      780

ctggaggcgc gctggtttct ggacgcgtac gctacacgcc acgatatgaa tcccattatc      840

ttggagctcg caaaactgga ctttaatatt attcaagcaa cccaccaaga agagctcaag      900

gacgtgagcc gttggtggca gaatacgcgc ctggccgaaa agctcccgtt tgtgcgcgat      960

cgacttgtcg agtcatactt ttgggccatc gcactctttg agccacatca atatggatac     1020

cagcgccgtg ttgctgccaa gattatcacc ctcgcgacat ccatcgatga cgtgtacgac     1080

atctacggca ctctcgacga gctccaactt tttaccgata acttccgtcg ctgggacacg     1140

gaatccttgg gcggtcttcc ttactcgatg cagttgttct acatggtgat tcacaacttt     1200

gtctctgagt tggcctatga aatcctgaaa gaaaaaggtt ttatcgccat cccctacctc     1260

caacgctcct gggttgattt ggcagaatcc tttttgaaag aggcaaactg gtactactct     1320

ggttatacac cctccctcga agaatacatc gacaacggct ccatctcaat tggcgcagta     1380

gctgtgttgt cccaagttta tttcactttg gcaaattcta tcgaaaagcc aaagattgaa     1440

tctatgtaca agtaccacca tattttgcgt ctgtcgggtt tgttggtgcg cctgcacgat     1500

gacttgggaa cttccttgtt cgagaagaag cgcggcgatg ttcctaaggc ggtcgaaatt     1560

tgcatgaaag aacgcaacga tacggaggag gaagcagaag aacacgttaa gtacttgatt     1620

cgcgaagcct ggaaggagat gaacactgct acggcagctg caggatgtcc ttttatggat     1680

gagctcaacg tggctgctgc caatctgggt cgcgcagccc agttcgtgta cctcgacgga     1740

gacggtcatg gcgtgcagca ctccaaaatc catcaacaga tgggtggcct tatgtttaaa     1800

ccgtatgtg                                                             1809


<210>  94
<211>  1809
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  94
atgtgctcta tttcccaaaa agtagttatt ggccttaaca aggcggctgc taacaactgc       60

ttacaaaatc ttgacagacg tggtttcaaa actcgtagag tttcatcttc cgaggccgct      120

agctgcctgc gggcctctag ctctttgcag ctggacgtta aaccagtgga agaggggcgc      180

agatcgggga actatcagcc atcgatctgg gactttaatt acgtacaatc actgaatact      240

ccttacaaag aagaacggta tctgacacgg cacgcagaac tgattgtcca agtgaaacca      300

ctgctggaaa agaagatgga agccacccaa caactggaac tcatcgacga cctgaacaac      360

ttgggactgt cctacttttt tcaggacaga attaaacaaa ttctttcatt tatatacgac      420

gaaaatcaat gctttcattc taatatcaac gatcaagccg aaaaacggga cctttacttc      480

acggctttag gttttcgtct gcttagacag catggcttca atgtgagtca agaagtattc      540

gactgcttta aaaacgataa gggatcagac tttaaagctt cattatcagg taacaccaaa      600

ggcttgcttc aattgtatga agcgagtttt ttagtccgag aaggggaaga tactcttgaa      660

ttagcccgac agttcgcgac taaattcctg cgtagaaaac tggatgaaat cgacgataac      720

catcttttaa gccgcattca tcattccttg gaaattccgt tacattggcg cattcagcgg      780

ttggaagcac gctggttcct tgacgcttat gctacgcgtc atgacatgaa tccaatcatc      840

ctcgaactcg cgaaacttga ctttaatatt attcaagcta cacatcaaga agaacttaaa      900

gacgtatcta gatggtggca gaacacacgt ctggccgaga aacttccgtt tgtccgggac      960

agattagtgg aatcttattt ctgggctatt gctctttttg aacctcatca atatgggtac     1020

caacgtcgag ttgctgctaa gattattaca ttggcaacaa gcattgatga tgtttacgat     1080

atttacggga ctttggatga attacaactt tttacggata attttcggag atgggataca     1140

gagtccctgg gtgggcttcc gtattctatg cagctgtttt atatggttat ccataatttc     1200

gtgagcgaac ttgcgtatga aattctgaaa gaaaaaggct ttatagccat tccttatctt     1260

cagagaagtt gggttgacct ggccgagtcc tttctcaaag aggcgaactg gtactattcc     1320

ggctataccc ctagcctgga agaatacatc gataacgggt ctatcagcat aggcgcagtc     1380

gcagtgcttt cacaggttta ttttacgttg gctaacagta ttgaaaaacc taagatagag     1440

agcatgtata aatatcacca tatcttgcgc ttatctggtt tgttagtccg cttacatgat     1500

gaccttggaa caagtctgtt cgagaagaag cggggcgatg taccgaaggc ggttgagatt     1560

tgcatgaaag aacggaatga cacagaagaa gaagcagaag aacatgttaa atacctgatc     1620

cgcgaagctt ggaaagaaat gaacacagct acagcagctg ccgggtgtcc gtttatggat     1680

gaattgaatg tcgcggcggc aaatctgggt cgggcagccc agtttgtata tttggatggg     1740

gacggccatg gcgtccagca tagtaaaatt catcaacaga tgggaggctt gatgttcaaa     1800

ccttacgtc                                                             1809


<210>  95
<211>  1809
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  95
atgtgttcaa tatcacaaaa agtcgtaatt gggttgaaca aggccgctgc caataactgt       60

ttgcagaatt tggataggag gggtttcaaa acaagaaggg tcagctcttc cgaggcggca      120

tcatgcttaa gagcttccag tagcttgcaa ctagatgtta aaccagtcga ggagggtaga      180

aggtcaggga actaccaacc aagtatctgg gatttcaatt atgtccaatc attgaatact      240

ccctataagg aggagcgtta cttaactaga catgcggaac tgattgtcca agtgaaacct      300

ttgttagaaa agaagatgga agctactcaa cagctggaat taattgacga tctaaataat      360

ttaggtttgt cttatttttt ccaagatagg atcaagcaaa tattgtcatt tatctatgac      420

gagaatcaat gtttccactc taacattaac gaccaggcag aaaagaggga cctgtatttt      480

accgcattgg gttttaggct tctacgtcag catggtttta atgtttctca agaagttttt      540

gattgcttta aaaatgacaa aggtagcgat tttaaggcta gcttatctgg caacaccaaa      600

ggtttgttgc aactatacga agcttctttt ctggtgagag aaggggaaga tactctagaa      660

ctagctagac aattcgctac caaatttctg aggagaaaat tggatgaaat tgatgataac      720

catctattaa gcagaataca ccattctcta gagattccat tgcattggag aatccaacgt      780

ttggaagcca ggtggttctt ggatgcttat gcaacacgtc atgatatgaa cccaattatt      840

ttggagcttg ccaaacttga ttttaacata attcaggcta cccatcaaga agaacttaag      900

gatgtttcca gatggtggca gaacactcgt ttggctgaaa agcttccatt tgtaagagat      960

agactagtcg aatcatactt ttgggcaatc gccttatttg aaccacatca gtacggttac     1020

caacgtagag tcgccgctaa aataataact ttggccactt ctatagatga tgtttatgat     1080

atttacggga cattagatga attgcaactt ttcaccgaca atttcagaag atgggatacc     1140

gaaagcctag gcggtctacc ttatagtatg caattgttct atatggttat tcataatttt     1200

gtttcagaat tggcttacga aatactgaaa gaaaaaggtt tcattgccat tccttattta     1260

caaaggagtt gggtggactt agcagaaagc tttctgaaag aggcgaattg gtattattca     1320

ggttatactc cgtctctgga ggagtatatt gataacggca gcatctctat tggtgcagtg     1380

gcagtattga gccaagtcta ctttacctta gctaacagca ttgaaaaacc aaaaattgag     1440

tccatgtata aataccatca catcttaaga ctttctggat tgttagtacg tttacacgac     1500

gatctgggca ccagtttgtt cgaaaaaaaa aggggcgacg tccctaaggc agtagaaatt     1560

tgtatgaaag aaaggaacga tacagaagaa gaagctgaag agcatgtgaa atatctgatt     1620

agagaggcgt ggaaggaaat gaacacagct acagctgctg cagggtgtcc attcatggat     1680

gaattaaacg tagctgcagc caatctgggt cgtgccgctc agttcgttta tttagacggt     1740

gatggtcatg gggttcagca ttccaagata caccaacaaa tggggggttt aatgtttaag     1800

ccttatgta                                                             1809


<210>  96
<211>  1809
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  96
atgtgttcca tctcgcagaa agttgtgatc ggcctgaaca aggctgccgc taacaactgt       60

ctccagaacc tggatcgacg aggtttcaag acaagacggg tgtcttcttc cgaggctgct      120

tcctgcctgc gagcatctag ctcccttcag cttgacgtca agcctgtcga ggagggtcga      180

cggtctggca actaccaacc ctccatttgg gacttcaatt acgtgcaatc gctgaacact      240

ccttacaagg aggagcgata cctcacccga cacgccgagc tcattgttca ggtcaagccc      300

ctccttgaga agaagatgga ggcaacccag cagctggagc tgattgatga cctgaacaac      360

ctgggcctct cctacttctt tcaggaccgg attaagcaaa ttctgtcctt tatttacgac      420

gagaaccaat gttttcattc taacatcaac gaccaggctg aaaagcgaga tctttacttc      480

accgccctcg gattccgtct cctccgacag cacggcttta acgtttcgca agaggtcttt      540

gattgcttta agaatgataa aggctccgac ttcaaggctt ctctttctgg taacaccaag      600

ggtctgctgc aactgtacga agcttccttt cttgttagag agggcgagga taccctggag      660

ctggcccggc agtttgctac caagttcctg cgacgaaagc tggatgagat tgacgacaac      720

caccttctgt cccgaatcca ccactcgctt gagatccccc tccactggcg aatccagcga      780

ctggaagcta gatggtttct ggatgcctac gctactcgac acgacatgaa tcctattatc      840

ctggagctgg ccaagcttga cttcaacatc atccaggcca cccaccagga ggaactgaaa      900

gacgtctctc gatggtggca gaacacccga cttgccgaaa agctcccctt tgtgcgagac      960

cgactggtcg agagctactt ttgggctatt gccctctttg agccccacca gtacggttac     1020

cagcgaagag tcgctgctaa aatcatcacc ctggccacta gcatcgacga cgtttacgac     1080

atttacggaa ccctcgatga gctgcaactg tttaccgata actttcggcg ttgggacaca     1140

gaaagccttg gaggtctgcc ctactctatg cagctcttct atatggtgat ccacaacttt     1200

gtgtctgagc tggcttatga gatccttaag gaaaagggct tcatcgccat cccttacctt     1260

cagcgatcct gggtcgatct tgccgagtct ttcctcaagg aggccaactg gtattactct     1320

ggctacaccc catctctgga ggagtatatt gataacggtt ctatttctat cggcgccgtg     1380

gctgtccttt cccaagtcta tttcacactg gctaattcca tcgagaagcc caagattgaa     1440

tctatgtaca aataccatca catcctgcga ctgagcggtc ttctggtgcg gcttcatgac     1500

gatcttggca cttctctgtt cgagaagaaa cgaggagatg tgcctaaggc tgtcgagatt     1560

tgtatgaaag agcgtaacga caccgaggag gaggccgagg agcacgtgaa gtacctgatt     1620

cgagaggcat ggaaagaaat gaacaccgct actgccgccg ctggttgccc ctttatggat     1680

gagctgaacg ttgcagccgc caaccttggc cgagcagccc agttcgtcta cctggacggc     1740

gacggccacg gcgtccagca ttctaaaatt caccagcaga tgggtggcct gatgttcaag     1800

ccctatgtc                                                             1809


<210>  97
<211>  591
<212>  PRT
<213>  Vitis vinifera (Grape)

<400>  97

Met Ser Arg Phe Val Thr Met Pro Ser His Val Leu Pro Ser Ser Phe 
1               5                   10                  15      


Val Ala Pro Ser Leu Gln Val Ser Ser Ser Pro Cys Ser Trp Arg Thr 
            20                  25                  30          


Arg Pro Ser Pro Cys Thr Ser Cys His Leu Ser Pro Ser Ser Ser Ser 
        35                  40                  45              


Lys Pro Leu Leu Gly Ser His Asp Tyr Ser Leu Leu Lys Ser Leu Thr 
    50                  55                  60                  


Leu Ser Pro His Ala Val Asn Ser Glu Ala Asp Ser Ser Thr Arg Arg 
65                  70                  75                  80  


Met Lys Glu Val Lys Glu Arg Thr Trp Glu Ala Phe Tyr Arg Ala Trp 
                85                  90                  95      


Asp Ser Arg Ala Ala Met Glu Met Val Asp Thr Val Glu Arg Leu Gly 
            100                 105                 110         


Leu Ser Tyr His Phe Glu Asp Glu Ile Asn Ala Leu Leu Gln Arg Phe 
        115                 120                 125             


Cys Asp Trp Asn Ala Ser Glu Asp Leu Phe Thr Thr Ala Leu Arg Phe 
    130                 135                 140                 


Arg Leu Leu Arg Gln Asn Gly Phe Pro Thr His Ser Asp Val Phe Gly 
145                 150                 155                 160 


Lys Phe Met Asp Lys Asn Gly Lys Phe Lys Glu Ser Leu Thr Glu Asp 
                165                 170                 175     


Ile Trp Gly Met Leu Ser Leu His Glu Ala Ser His Leu Gly Ala Lys 
            180                 185                 190         


Asn Glu Glu Val Leu Ala Glu Ala Lys Glu Phe Thr Arg Ile His Leu 
        195                 200                 205             


Ile Gln Ser Met Pro His Met Glu Pro His Phe Ser Ser His Val Gly 
    210                 215                 220                 


Arg Ala Leu Glu Leu Pro Arg His Leu Arg Met Val Arg Leu Glu Ala 
225                 230                 235                 240 


Arg Asn Tyr Ile Gly Glu Tyr Ser Arg Glu Ser Asn Pro Asn Leu Ala 
                245                 250                 255     


Phe Leu Glu Leu Ala Lys Leu Asp Phe Asp Met Val Gln Ser Leu His 
            260                 265                 270         


Gln Lys Glu Leu Ala Glu Ile Val Arg Trp Trp Lys Gln Leu Gly Leu 
        275                 280                 285             


Val Asp Lys Leu Asp Phe Ala Arg Asp Arg Pro Met Glu Cys Phe Leu 
    290                 295                 300                 


Trp Thr Val Gly Ile Phe Pro Asp Pro Arg His Ser Ser Cys Arg Ile 
305                 310                 315                 320 


Glu Leu Thr Lys Ala Ile Ala Ile Leu Leu Val Ile Asp Asp Ile Tyr 
                325                 330                 335     


Asp Ser Tyr Gly Ser Leu Asp Glu Leu Ala Leu Phe Thr Asp Ala Val 
            340                 345                 350         


Lys Arg Trp Asp Leu Gly Ala Met Asp Gln Leu Pro Glu Tyr Met Lys 
        355                 360                 365             


Ile Cys Tyr Met Ala Leu Tyr Asn Thr Thr Asn Asp Ile Ala Tyr Arg 
    370                 375                 380                 


Ile Leu Lys Glu His Gly Trp Ser Val Ile Glu Asp Leu Lys Arg Thr 
385                 390                 395                 400 


Trp Met Asp Ile Phe Gly Ala Phe Leu Ala Glu Ala Tyr Cys Phe Lys 
                405                 410                 415     


Gly Gly His Val Pro Ser Leu Glu Glu Tyr Leu Thr Asn Ala Val Thr 
            420                 425                 430         


Thr Gly Gly Thr Tyr Met Ala Leu Val His Ala Phe Phe Leu Met Gly 
        435                 440                 445             


Gln Gly Val Thr Arg Glu Asn Met Ala Met Leu Lys Pro Tyr Pro Asn 
    450                 455                 460                 


Ile Phe Ser Cys Ser Gly Lys Ile Leu Arg Leu Trp Asp Asp Leu Gly 
465                 470                 475                 480 


Thr Ala Arg Glu Glu Gln Glu Arg Gly Asp Asn Ala Ser Ser Ile Glu 
                485                 490                 495     


Cys Tyr Lys Arg Glu Arg Glu Met Asp Thr Val Leu Glu Asp Glu Ala 
            500                 505                 510         


Cys Arg Lys His Ile Arg Gln Met Ile Gln Ser Leu Trp Val Glu Leu 
        515                 520                 525             


Asn Gly Glu Leu Val Ala Ser Ser Ala Leu Pro Leu Ser Ile Ile Lys 
    530                 535                 540                 


Ala Ala Phe Asn Leu Ser Arg Thr Ala Gln Val Ile Tyr Gln His Gly 
545                 550                 555                 560 


Asp Asp Asn Lys Thr Ser Ser Val Glu Asp His Val Gln Ala Leu Leu 
                565                 570                 575     


Phe Arg Pro Val Ser Ser Asn Gly His Ala Gln Ile Thr Met His 
            580                 585                 590     


<210>  98
<211>  1773
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  98
atgtctcgct tcgttacaat gccatctcat gtattaccta gttcattcgt tgcgcctagc       60

ctgcaggtgt cgtctagccc gtgttcttgg agaactcggc cgtccccttg cacttcatgc      120

catttatcac cgagctcttc atcaaaacct ctcttaggat ctcacgatta ttcacttttg      180

aaatccttaa cgttatctcc acacgccgta aactcggaag cagattcatc cacacggcgc      240

atgaaagagg tgaaagaaag aacgtgggaa gccttttatc gagcatggga tagtagagct      300

gccatggaga tggtggacac agtcgagcgc cttggacttt cctatcactt tgaagatgaa      360

attaatgcgc tgcttcaaag attttgcgac tggaacgcgt cagaggattt gtttacaacc      420

gccttaagat ttagactgct tcggcagaat gggtttccta ctcactccga tgtgtttgga      480

aagtttatgg acaagaacgg aaaatttaag gagagtctga cggaagatat ttggggtatg      540

ctttcgcttc atgaagcttc acatcttggg gcaaaaaacg aggaagtcct tgctgaagca      600

aaagagttta ctcgaataca tcttattcag tctatgccgc atatggagcc tcatttctcg      660

tcacacgtag gtcgggcact tgaactccct cgtcatctcc ggatggtgcg tctcgaagct      720

cgtaattata tcggggaata ttcacgtgaa agcaacccga acctcgcatt ccttgaattg      780

gccaaattgg atttcgatat ggtacaatca ttgcatcaaa aagagctggc ggaaattgtt      840

cgatggtgga aacaattagg attagtcgac aaattagatt ttgctcgcga tcggccgatg      900

gagtgttttc tctggaccgt tggtatcttc ccggatcctc ggcattccag ctgtcgtatt      960

gaattgacga aagctattgc gattctgttg gtcattgacg atatttatga ttcatatgga     1020

agcttggatg aactggcttt atttactgat gctgttaaaa gatgggatct gggtgcgatg     1080

gatcaacttc cggagtatat gaaaatctgc tacatggctc tgtacaacac aacaaacgat     1140

atagcataca gaatattaaa agagcacggc tggagcgtaa ttgaagattt aaaacgcaca     1200

tggatggaca tctttggggc gtttttggca gaagcatact gtttcaaagg tggacatgtt     1260

ccgagccttg aggaatactt aacaaacgca gtcacgactg gcggcaccta tatggccctt     1320

gttcacgcgt tctttcttat gggacaaggc gtgactcgtg aaaatatggc catgcttaaa     1380

ccgtatccta atatcttctc atgtagcggt aaaattcttc gactttggga tgacttgggt     1440

acagctcgag aagaacaaga gcgcggggat aatgcgagct ccattgaatg ctacaaaaga     1500

gaaagagaaa tggatacggt actggaagat gaagcatgta gaaaacatat cagacagatg     1560

atccaatcac tgtgggtgga acttaacggc gagctggtgg ccagcagcgc tctgccgttg     1620

tcaattataa aagccgcgtt taacctttcc cgtacagctc aagttatcta tcagcacggt     1680

gatgataaca aaacatcatc agttgaagac catgtccaag cccttttgtt tcgtccggta     1740

tcttcaaatg gtcatgctca aatcacgatg cat                                  1773


<210>  99
<211>  1773
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  99
atgtcccgtt ttgtcactat gccatcgcac gtcttgccta gcagcttcgt agcgccatct       60

ctgcaagtgt cttcatcccc atgctcgtgg cgcacccgcc cttccccatg cacctcttgt      120

cacttgtcac catcctcttc ttcaaaacca cttttgggca gccacgatta ctccctgctt      180

aagagcctga ccctttctcc acacgccgtg aattccgaag cggattcttc cacccgccga      240

atgaaggaag tcaaggagcg cacatgggaa gctttctatc gagcctggga ttcacgtgct      300

gctatggaga tggttgacac cgtggaacgt ctgggtcttt cataccactt tgaggacgaa      360

attaatgcgc tcttgcagcg cttttgtgat tggaacgctt ccgaagatct gttcacaacc      420

gccttgcgtt tccgccttct gcgccagaac ggttttccta cccattctga cgtctttggc      480

aaattcatgg ataagaacgg aaaattcaag gaaagcttga ctgaggatat ctggggaatg      540

ctgtcattgc atgaggcatc gcacttgggc gcaaaaaacg aggaggtcct cgcggaagca      600

aaggagttca cccgcatcca tctgatccaa tcaatgccgc atatggaacc tcacttctcc      660

tcccacgtcg gacgcgctct ggaactccct cgccatcttc gcatggtgcg actcgaagct      720

cgcaattata tcggcgagta ctcccgcgag agcaacccga atcttgcatt cttggaactc      780

gcgaagttgg attttgacat ggtgcagtca ctccaccaaa aggaactcgc ggagatcgtt      840

cgctggtgga aacagctggg tctcgtggac aagttggatt tcgcgcgcga ccgacctatg      900

gaatgcttcc tctggaccgt gggcatcttt cctgatcctc gacattcctc ttgtcgcatc      960

gaattgacta aagcaatcgc catcctcctg gttatcgacg atatttatga ctcatatggc     1020

agcctcgacg aattggcact gttcacagac gcagtcaaac gctgggattt gggagcgatg     1080

gatcagttgc ccgaatatat gaagatctgc tatatggcac tttacaacac cacaaacgat     1140

atcgcgtacc gcatccttaa agaacatggt tggtccgtta tcgaagactt gaagcgcacc     1200

tggatggaca tcttcggtgc gttcctcgcg gaggcatact gtttcaaagg cggtcacgta     1260

ccctctctcg aggaatacct caccaatgca gtcaccactg gaggcactta tatggccctg     1320

gtccacgctt ttttcctcat gggtcagggc gtgacccgcg aaaatatggc catgcttaag     1380

ccatacccaa acattttctc atgttccgga aaaattctgc gcctttggga cgatcttggt     1440

accgctcgcg aggagcaaga acgcggagac aacgcttctt ccatcgagtg ctataaacga     1500

gagcgcgaaa tggacaccgt gctcgaagac gaagcatgtc gcaagcatat ccgccaaatg     1560

atccagtcac tttgggtgga gcttaacggt gagctcgtgg catcttcggc tcttccactg     1620

tccattatta aggcggcgtt caacctgtct cgcacggcac aagtcatcta ccaacacgga     1680

gacgataaca agacttcgtc tgtggaggac catgtacagg ccttgctgtt tcgtcccgtt     1740

tcttcaaacg gccacgctca aatcaccatg cac                                  1773


<210>  100
<211>  1773
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  100
atgagtagat ttgttactat gccctcacat gtcctaccat cttcttttgt agccccttcc       60

ttgcaagtca gctcaagtcc gtgtagttgg agaactaggc cgagcccatg tacttcatgt      120

catttaagtc cgtcctcaag cagcaaacca ttgctgggat cccatgacta ttctttgcta      180

aaatccttga cgttgtctcc tcacgcagtt aactcagagg cagattcatc tacaaggaga      240

atgaaagaag tgaaagaaag aacttgggaa gcgttctaca gagcatggga ttcaagggca      300

gcaatggaaa tggtcgatac ggtggaaaga ttaggcttgt cataccattt tgaagacgaa      360

ataaatgctt tgcttcaaag gttctgtgac tggaatgcat ctgaggatct ttttacgacc      420

gcactaagat ttagactgtt gagacagaac ggcttcccaa cgcatagcga tgtgtttggt      480

aagttcatgg ataagaatgg gaaatttaag gagtccttaa ccgaagacat ctggggaatg      540

ttatccttgc atgaagcttc ccaccttggt gccaaaaacg aggaagtctt ggccgaagct      600

aaagaattca ccagaattca cctaatacaa tccatgcccc atatggaacc acatttctcc      660

tctcatgtgg ggagagcctt agagttgccg agacacttaa ggatggttag actagaagct      720

aggaactata tcggggaata ttcaagagaa agtaatccga atttggcgtt tttggagctt      780

gctaagttgg attttgatat ggttcaatcc ctgcaccaaa aagaactagc cgaaatagtt      840

aggtggtgga agcaattagg tctggttgat aaactggact ttgctagaga tagaccaatg      900

gagtgctttc tttggacggt aggtatcttc cctgacccaa ggcacagctc ttgtagaatt      960

gaacttacta aggcaatcgc catcctattg gtaattgatg atatctacga tagttatggt     1020

agtctggacg aattggcctt atttactgac gcagtaaaga gatgggatct aggtgctatg     1080

gatcagctgc ctgagtatat gaaaatctgt tacatggccc tttataacac cactaatgat     1140

atcgcatata gaatcttgaa ggagcacggt tggtcagtga ttgaagattt aaaaaggact     1200

tggatggata tttttggagc ttttcttgct gaagcttatt gctttaaagg tggtcatgtc     1260

ccctcattag aagaatacct gaccaatgcc gtgactactg gtggtaccta catggcttta     1320

gtgcatgcct tttttcttat gggtcaaggc gttactcgtg aaaacatggc aatgctgaaa     1380

ccatatccca atatattcag ctgctcaggt aagattttac gtttatggga cgatcttggt     1440

actgcaagag aagaacaaga aaggggggac aatgcatcca gcattgaatg ctataaaaga     1500

gaacgtgaaa tggacacagt gttagaagat gaagcttgca gaaaacatat aagacaaatg     1560

attcaatctt tatgggttga actaaacggg gagctagtgg cgtcaagtgc gcttccctta     1620

agtatcatca aggcagcttt taacctaagt agaaccgcac aagttattta ccagcacggc     1680

gatgataaca aaacctcctc agttgaagac cacgttcaag ctctattatt ccgtccagtt     1740

tcaagtaacg gacatgccca aattacaatg cat                                  1773


<210>  101
<211>  1773
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  101
atgtcgcgat tcgttaccat gccctcccac gtgcttccat cgtccttcgt tgctccatct       60

ctccaggttt cgtcgtctcc ctgttcttgg agaactcgac cttccccctg tacttcttgt      120

catctgtccc ccagctcgtc gtccaaacct ctgctgggta gccacgatta cagcctcctg      180

aagtctctca ccctttctcc tcacgctgtt aactccgagg ccgattcctc cacccgacgg      240

atgaaagagg tgaaggagcg aacttgggaa gccttctacc gagcttggga ctcccgggcc      300

gcaatggaga tggtcgacac tgtcgaaaga ctgggtctgt cttaccactt tgaggatgag      360

atcaacgctc tcctccagag attctgtgat tggaacgcct cggaggacct gttcacgacc      420

gctctccgat tccgactcct gagacagaac ggcttcccca cacattcgga cgtcttcggc      480

aagttcatgg acaagaacgg aaagttcaag gagtcgctca cggaagacat ctggggaatg      540

ctttctctcc atgaggcctc gcacctgggc gctaagaatg aggaggtcct cgccgaggcc      600

aaggagttta cccgaatcca ccttatccag agcatgcctc acatggagcc tcacttttcc      660

tcccacgtcg gtcgagccct tgagctgccc cgacatcttc gaatggtccg actggaggct      720

cgtaactaca ttggcgagta ctctagagag tccaacccca acctggcctt cctcgaactc      780

gccaagctgg atttcgacat ggtccagtcg ctgcaccaga aggagctcgc cgagattgtc      840

cgatggtgga agcaactcgg ccttgtcgac aaactggatt tcgctcgaga tcgacccatg      900

gagtgcttcc tgtggaccgt tggtattttc cccgaccccc gtcactcttc ctgccgaatc      960

gagctgacca aggccatcgc cattctgctc gttattgatg acatttacga ctcctacgga     1020

agccttgacg agctcgcact cttcaccgac gccgtgaagc gatgggatct gggtgccatg     1080

gatcaactgc ccgagtacat gaagatctgc tacatggccc tttacaacac aaccaacgac     1140

atcgcttacc gaatccttaa ggagcacgga tggtctgtta ttgaggacct caagcgaacg     1200

tggatggata tcttcggagc ctttctggct gaggcctact gtttcaaggg aggccatgtc     1260

ccttcgctcg aagagtatct gaccaacgct gtcaccaccg gtggtactta catggctctg     1320

gtccacgcat tcttcctgat gggtcaagga gtcacaagag agaatatggc tatgcttaag     1380

ccctatccca acattttttc ttgctctgga aagattctcc ggctctggga tgacctcggc     1440

actgctcgag aggagcagga gcgaggcgat aacgcttcct cgattgagtg ctacaagcga     1500

gagcgagaga tggataccgt ccttgaggac gaggcttgcc gtaagcatat tcgtcaaatg     1560

attcagtcgc tctgggttga gctgaacgga gaactggttg catcgtccgc cctccctctg     1620

tcgatcatca aagccgcttt caacctctcg agaactgctc aggtgattta ccagcacgga     1680

gatgacaaca agaccagctc tgtcgaagac cacgtccagg ctctgctttt cagacctgtg     1740

tcctcgaacg gtcacgctca aattaccatg cac                                  1773


<210>  102
<211>  501
<212>  PRT
<213>  Phaseolus angularis (Azuki bean) (Vigna angularis)

<400>  102

Met Glu Thr Asn Ser Thr Leu Phe Phe Thr Phe Thr Val Leu Leu Ile 
1               5                   10                  15      


Thr Ile Ile Thr Phe Leu Lys Ala Leu Lys Ser Leu Phe Thr Pro Asn 
            20                  25                  30          


Lys Ser Lys Ser Asn Leu Pro Pro Gly Pro Lys Gly Leu Pro Leu Val 
        35                  40                  45              


Gly Asn Leu Leu Gln Leu Gly Ala Lys Pro His Gln Thr Leu Ala Thr 
    50                  55                  60                  


Leu Ala Asn Ile His Gly Ser Ile Met Ser Leu Lys Leu Gly Gln Glu 
65                  70                  75                  80  


Thr Thr Ile Val Met Ser Ser Ala Glu Ala Ala Lys Gly Val Leu Gln 
                85                  90                  95      


Ile His Asp His Phe Leu Ser Asn Arg Lys Ile Pro Asp Ala Met Arg 
            100                 105                 110         


Gly Ser Ser His Asp His Phe Ser Leu Pro Phe Met Pro Val Ser Gln 
        115                 120                 125             


Gln Trp Arg Glu Leu Arg Lys Leu Cys Asn Glu Leu Leu Phe Ser Asn 
    130                 135                 140                 


Lys Asn Leu Asp Ala Thr Gln Gly Leu Arg Ser Lys Lys Val Arg Glu 
145                 150                 155                 160 


Leu Tyr Ser Asp Ile His Arg Ser Ser Leu Lys Gly Glu Pro Val Asn 
                165                 170                 175     


Ile Gly Arg Leu Ala Phe Lys Thr Thr Ile Asn Gln Leu Ser Asn Thr 
            180                 185                 190         


Ile Tyr Ser Glu Asp Phe Leu Gln Ser Ala Glu Lys Ala Gly Glu Met 
        195                 200                 205             


Lys Glu Leu Val Thr Asn Ile Met Lys Glu Val Gly Arg Pro Asn Leu 
    210                 215                 220                 


Ala Asp Cys Phe Pro Val Leu Lys Met Ile Asp Pro His Gly Ile Arg 
225                 230                 235                 240 


Arg Arg Thr Gly Ser Tyr Phe Ser Lys Leu Leu Asn Ile Phe Lys Ser 
                245                 250                 255     


Leu Ile His Lys Arg Leu Glu Leu Arg Lys Asp Ala Ala Gly Tyr Cys 
            260                 265                 270         


Thr Lys Lys Asp Met Leu Asp Ala Met Leu Asn Asp Ala Gln His Lys 
        275                 280                 285             


Met Asp Ile Val Lys Ile Gln Arg Leu Ser Leu Asp Leu Phe Val Ala 
    290                 295                 300                 


Gly Thr Asp Thr Val Thr Ser Thr Val Glu Trp Ala Met Ala Glu Leu 
305                 310                 315                 320 


Leu His Asn Pro His Val Met Ser Lys Ala Lys Glu Glu Leu Glu Arg 
                325                 330                 335     


Ile Ile Gly Lys Asp Asn Leu Val Glu Glu Ser Asp Ile Ala Lys Leu 
            340                 345                 350         


Pro Tyr Leu Gln Ala Ile Val Lys Glu Thr Phe Arg Leu His Pro Ala 
        355                 360                 365             


Val Pro Leu Leu Leu Pro Arg Lys Ala Glu Val Glu Phe Glu Met His 
    370                 375                 380                 


Gly Tyr Thr Ile Pro Lys Gly Ala Gln Val Leu Ile Asn Val Trp Ala 
385                 390                 395                 400 


Ile Gly Arg Asp Pro Asn Leu Trp Glu Lys Pro Arg Leu Phe Trp Pro 
                405                 410                 415     


Glu Arg Phe Leu Glu Ser Glu Ile Asp Phe Lys Gly Arg Ser Phe Glu 
            420                 425                 430         


Leu Thr Pro Phe Gly Gly Gly Arg Arg Ile Cys Pro Gly Leu Pro Leu 
        435                 440                 445             


Ala Ile Arg Leu Val Phe Leu Met Leu Gly Leu Phe Ile Asn Ser Phe 
    450                 455                 460                 


Asp Trp Glu Leu Gln Asp Ile Gln Pro Glu Asp Met Asn Met Asp Glu 
465                 470                 475                 480 


Asn Phe Gly Leu Thr Leu Glu Lys Ala Gln Pro Val Leu Ala Ile Pro 
                485                 490                 495     


Ile Ile Pro Lys His 
            500     


<210>  103
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  103
atggagacta actctaccct tttctttaca ttcaccgtcc tcctgatcac aatcattacg       60

ttcctgaagg cgttgaaatc tttgtttacc cctaacaagt caaaatctaa cctcccaccc      120

ggtcccaagg gccttccttt ggttggcaac ctgcttcagt tgggcgcgaa gccgcaccag      180

accctcgcaa ccctcgcaaa catccacgga tccatcatgt ccctcaaatt gggtcaagag      240

acaaccatcg tgatgtcttc cgctgaggcc gcaaagggag ttctgcagat tcatgatcat      300

ttcctctcaa accgcaaaat ccccgacgca atgcgcggct cctcccacga ccacttctcc      360

cttcctttca tgcctgtttc ccaacagtgg cgagaattgc gaaagctttg caacgaactc      420

ctgttctcca acaagaacct ggacgctaca caaggcctgc gctccaaaaa ggttcgagaa      480

ctgtacagcg atattcaccg cagctcgctg aagggcgagc ccgtgaacat cggtcgtctg      540

gcttttaaaa cgaccatcaa ccaactttct aacaccatct actcggaaga cttcttgcaa      600

tccgccgaga aagcgggcga aatgaaggaa ctcgttacca atattatgaa ggaggttggc      660

cgcccgaacc ttgccgactg cttccccgtt ctgaaaatga tcgaccccca cggcatccgc      720

cgtcgaaccg gctcttactt cagcaagctg cttaatatct tcaaatccct gatccacaag      780

cgtctggaac ttcgtaaaga tgctgcgggc tactgtacta aaaaggatat gcttgacgcg      840

atgctgaacg acgcccaaca caaaatggac atcgttaaga tccagcgtct ctctcttgat      900

ttgttcgttg caggaacgga taccgtcacc tccactgtcg agtgggctat ggctgaactg      960

cttcacaacc cccacgttat gtcaaaggct aaagaggaac tcgaacgcat tatcggtaag     1020

gataatctgg tggaggagtc agacatcgcc aagttgcctt acttgcaggc tatcgtgaag     1080

gagaccttcc gtctccaccc agcagtcccc cttttgctgc cacgcaaagc cgaggttgaa     1140

tttgaaatgc acggttacac aatccccaaa ggcgcccagg tcctgatcaa tgtctgggcc     1200

attggtcgcg acccgaactt gtgggaaaag ccacgcctgt tttggcccga gcgatttctt     1260

gaatccgaga tcgacttcaa gggccgatcg ttcgagctca ccccgttcgg cggcggccgt     1320

cgcatctgcc ctggactccc attggcgatc cgacttgttt ttctgatgct cggcctgttt     1380

attaactctt tcgattggga acttcaggac attcagccgg aagacatgaa tatggacgaa     1440

aacttcggtc tgactcttga aaaggcccag ccagttctcg caattccaat cattccaaaa     1500

cac                                                                   1503


<210>  104
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  104
atggaaacca acagtacttt attctttaca tttacagtcc ttcttatcac tatcataaca       60

tttctcaagg cgctcaaaag tttattcacg ccgaataaat caaaatcaaa tcttccgcct      120

ggaccaaaag gactcccgct ggttggaaat cttttgcaac tcggggcaaa acctcatcag      180

acattagcta cgcttgctaa cattcacgga agcattatgt ctctgaagtt aggtcaagaa      240

acaacaattg tcatgtcttc ggcggaggcg gctaaaggcg ttttgcagat ccacgatcat      300

tttctgagca accggaaaat tcctgacgcc atgcgtggta gctcacatga tcatttctca      360

ttaccgttca tgccagtaag ccaacaatgg cgcgagctga gaaaactgtg taatgagtta      420

ttattttcaa ataaaaactt ggatgcaacg caggggctga gaagcaaaaa agttcgtgaa      480

ctgtattcag atatacatcg ctcgtctctt aaaggcgaac cggtcaacat cgggagactt      540

gcttttaaaa caacaattaa ccaattgagc aatacgatct actcggagga cttccttcaa      600

agcgcggaaa aagcaggtga aatgaaggaa ctggtcacaa acatcatgaa ggaagtggga      660

cgtccgaatc tggctgactg ttttccggtg ctgaaaatga ttgatcctca cggaattcgc      720

cgccggacag gttcatattt ctcaaaactt ctgaatatat tcaaaagctt aattcataaa      780

cgcttagagt tgcgcaaaga tgctgcaggc tattgcacga agaaagatat gctggatgcg      840

atgctgaacg atgctcaaca taaaatggat atcgtgaaaa tccagcggct ctcactcgac      900

ttatttgttg ctggcacaga taccgtcacc tcgaccgtcg agtgggccat ggcagagttg      960

ctgcataatc cacacgtaat gtccaaagct aaagaagaac tggaaagaat cattggcaag     1020

gataacctcg ttgaagaaag cgacatcgcg aaacttcctt acttacaggc gattgtaaag     1080

gagacgttta gactgcatcc agcagtacct ctgcttcttc cgcgcaaagc tgaagtagaa     1140

tttgaaatgc atggatatac gatcccgaaa ggggcacagg tactcatcaa tgtgtgggcg     1200

attggcagag atccaaattt gtgggaaaaa cctcgtttgt tttggcctga aagattcctg     1260

gagtcagaaa ttgacttcaa gggcagatcc ttcgaactca cgccgtttgg cgggggccgg     1320

cgtatttgcc ctggcctgcc gttagccatt agattggttt tcttgatgtt aggcttattc     1380

atcaatagct tcgattggga gctccaggat attcaaccgg aagacatgaa tatggacgaa     1440

aactttggct taacactgga gaaagcacag ccggtactgg ccattccgat catcccgaaa     1500

cat                                                                   1503


<210>  105
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  105
atggaaacta acagcacttt attttttaca ttcacagtct tacttattac gataattacg       60

ttcctgaaag ctctgaaatc actatttact ccaaataaaa gtaagtctaa cttgccccct      120

ggcccaaagg gtttgccact tgttggaaat ctattgcaat taggtgcaaa acctcatcaa      180

acactggcta ctttggctaa tatacatggg tccattatga gcctaaagtt gggccaagag      240

acaactatag tgatgtcttc tgctgaagca gccaagggtg tcttgcaaat acatgatcat      300

ttcctgagca atagaaagat tcctgacgct atgaggggat caagccacga tcatttctca      360

ttgccattca tgcctgtatc ccagcaatgg agagaattaa gaaaattatg taatgaactg      420

ttattttcta acaagaatct ggatgcaaca cagggcttaa gatcaaagaa agttagggaa      480

ttatattcag atatccatcg tagttcttta aaaggcgaac cagtcaacat cggcagactg      540

gcatttaaaa ccaccattaa ccagttgtct aataccattt atagcgaaga tttcttacaa      600

tctgccgaaa aagctggcga gatgaaagaa ttggttacta atatcatgaa ggaagttggt      660

aggccgaacc ttgcagactg ctttcctgtc ttgaagatga tagatccaca tggcattaga      720

agaagaacgg gttcttattt ttctaagttg cttaatattt tcaaatcatt gatccacaag      780

aggttggagt tgagaaaaga tgcggcagga tattgtacga aaaaagacat gctggatgca      840

atgcttaacg atgctcagca taagatggat atagttaaga tccaaagatt atctttggat      900

ttgttcgtcg ccggtactga tactgttacc tccactgtag aatgggccat ggcagaattg      960

cttcataacc cgcatgtcat gtcaaaagct aaagaagaat tggaaagaat tattggcaag     1020

gataatctgg tagaggaaag tgacatagct aaacttccat acttgcaagc cattgttaag     1080

gagactttta gattgcatcc agcagtgcct cttcttttgc caagaaaggc tgaagtggaa     1140

tttgaaatgc acggctacac aattccaaaa ggagctcaag tgttgatcaa tgtatgggcc     1200

attggtcgtg acccaaatct atgggaaaaa ccacgtttat tctggccaga gagatttttg     1260

gaatcagaaa ttgacttcaa gggcaggtca ttcgagttga ccccattcgg cggtggtaga     1320

aggatatgtc ctggcttacc acttgccatc cgtttagtat ttttgatgct tgggctattc     1380

attaactctt ttgactggga gcttcaagat attcagcccg aggatatgaa catggatgag     1440

aatttcgggc tgacacttga aaaagcgcaa cctgtattag ctattccgat aattccaaaa     1500

cat                                                                   1503


<210>  106
<211>  1503
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  106
atggagacca actcgactct gttctttact tttactgttc tcctgatcac cattatcacc       60

ttcctcaagg cactgaagtc gctgttcacc cccaataagt cgaagagcaa cctccccccc      120

ggtcctaagg gcctccctct ggtgggaaac ctcctccagc tcggcgccaa acctcatcag      180

actctggcta ccctggccaa cattcacggc agcatcatgt cgctcaagct tggtcaggag      240

actactatcg tcatgtcgtc ggccgaggct gctaagggcg tccttcagat ccacgatcac      300

ttcctgtcta accgaaagat ccccgacgct atgagaggat cttctcacga ccatttctct      360

ctccctttca tgccagtctc gcagcagtgg cgagagcttc gaaagctctg taacgagctt      420

ctcttctcta ataagaacct tgatgctact cagggtctca gatctaagaa ggttcgagag      480

ctgtattcgg acattcatcg atcttctctg aagggtgagc ccgtcaacat tggtagactg      540

gctttcaaga caacaattaa tcagctctct aacacaattt acagcgagga cttcctccag      600

tcggctgaga aggccggtga aatgaaggaa ctcgtcacca acatcatgaa ggaagtgggc      660

cggcccaacc ttgctgattg cttccccgtt ctcaagatga ttgaccccca tggaatccgg      720

cgacggaccg gctcctattt ttccaagctc ctgaacattt tcaagtccct catccacaag      780

cgactcgaac tccgaaaaga cgccgccggt tactgtacca aaaaagacat gcttgacgct      840

atgctcaacg acgcacagca caagatggat attgtcaaga ttcagcgact gtccctcgac      900

ctgttcgtgg ctggaaccga caccgttaca tctacagtcg aatgggctat ggccgaactg      960

ctgcataacc ctcacgtgat gagcaaggct aaggaggagc ttgagcgaat catcggaaag     1020

gacaacctcg tggaggagtc ggacatcgcc aagctgcctt accttcaagc cattgttaag     1080

gagacctttc gactgcaccc agctgttcca ctgctgctcc caagaaaagc tgaggtcgag     1140

ttcgaaatgc acggatatac aatccccaag ggagctcagg ttcttatcaa cgtctgggct     1200

attggacgag accccaacct ctgggagaag cctcgactct tttggcctga gcgattcctc     1260

gagagcgaga ttgactttaa gggtagatct ttcgaactga ccccctttgg tggcggacga     1320

cggatctgcc ccggtctgcc cctcgctatt cgactggttt tcctcatgct tggcctcttc     1380

atcaatagct ttgactggga gcttcaagac attcagcctg aagacatgaa catggacgag     1440

aacttcggcc tgaccctgga gaaggcccag cccgtcctgg caatccccat catccccaag     1500

cac                                                                   1503


<210>  107
<211>  495
<212>  PRT
<213>  Swertia mussotii (Felwort)

<400>  107

Met Asp Phe Asp Phe Leu Thr Ile Ala Ile Gly Phe Leu Phe Thr Ile 
1               5                   10                  15      


Thr Leu Tyr Gln Ala Leu Asn Phe Phe Ser Arg Lys Ser Lys Asn Leu 
            20                  25                  30          


Pro Pro Gly Pro Ser Pro Leu Pro Leu Ile Gly Asn Leu His Leu Leu 
        35                  40                  45              


Gly Asp Gln Pro His Lys Ser Leu Ala Lys Leu Ala Lys Lys His Gly 
    50                  55                  60                  


Pro Ile Met Gly Leu Gln Leu Gly Gln Val Thr Thr Ile Val Val Thr 
65                  70                  75                  80  


Ser Ser Gly Met Ala Lys Glu Val Leu Gln Lys Gln Asp Leu Ala Phe 
                85                  90                  95      


Ser Ser Arg Ser Ile Pro Asn Ala Ile His Ala His Asp Gln Tyr Lys 
            100                 105                 110         


Tyr Ser Val Ile Trp Leu Pro Val Ala Ser Arg Trp Arg Gly Leu Arg 
        115                 120                 125             


Lys Ala Leu Asn Ser Asn Met Phe Ser Gly Asn Arg Leu Asp Ala Asn 
    130                 135                 140                 


Gln His Leu Arg Ser Arg Lys Val Gln Glu Leu Ile Ala Tyr Cys Arg 
145                 150                 155                 160 


Lys Ser Ser Gln Thr Gly Asp Ala Ile Asp Val Gly Arg Ala Ala Phe 
                165                 170                 175     


Arg Thr Ser Leu Asn Leu Leu Ser Asn Thr Met Phe Ser Lys Asp Leu 
            180                 185                 190         


Thr Asp Pro Tyr Ser Asp Ser Ala Lys Glu Phe Lys Asp Leu Val Trp 
        195                 200                 205             


Asn Val Met Val Glu Ala Gly Lys Pro Asn Leu Val Asp Tyr Phe Pro 
    210                 215                 220                 


Leu Leu Asp Lys Val Asp Pro Gln Gly Ile Arg Lys Arg Met Thr Ile 
225                 230                 235                 240 


His Phe Gly Lys Ile Leu Glu Leu Phe Gly Gly Leu Ile Asp Glu Arg 
                245                 250                 255     


Leu Gln Gln Lys Lys Ala Lys Gly Val Asn Asp Asp Val Leu Asp Val 
            260                 265                 270         


Leu Leu Thr Thr Ser Glu Glu Ser Pro Glu Glu Ile Asp Arg Thr His 
        275                 280                 285             


Ile Gln Arg Met Cys Leu Asp Leu Phe Val Ala Gly Thr Asp Thr Thr 
    290                 295                 300                 


Ser Ser Thr Leu Glu Trp Ala Met Ser Glu Met Leu Lys Asn Pro Glu 
305                 310                 315                 320 


Lys Met Lys Ala Ala Gln Ala Glu Leu Ala Gln Val Ile Gly Lys Gly 
                325                 330                 335     


Lys Ala Val Glu Glu Ala Asp Leu Ala Arg Leu Pro Tyr Leu Arg Cys 
            340                 345                 350         


Ala Ile Lys Glu Thr Leu Arg Ile His Pro Pro Val Pro Leu Leu Ile 
        355                 360                 365             


Pro Arg Arg Thr Glu Gln Glu Val Glu Val Cys Gly Tyr Thr Val Pro 
    370                 375                 380                 


Lys Asn Ser Gln Val Leu Val Asn Val Trp Ala Ile Ser Arg Asp Asp 
385                 390                 395                 400 


Ala Ile Trp Lys Asp Pro Leu Ser Phe Lys Pro Glu Arg Phe Leu Glu 
                405                 410                 415     


Ser Glu Leu Glu Met Arg Gly Lys Asp Phe Glu Leu Ile Pro Phe Gly 
            420                 425                 430         


Ala Gly Arg Arg Ile Cys Pro Gly Leu Pro Leu Ala Val Arg Met Val 
        435                 440                 445             


Pro Val Met Leu Gly Ser Leu Leu Asn Ser Phe Asp Trp Lys Leu Glu 
    450                 455                 460                 


Gly Gly Ile Ala Pro Lys Asp Leu Asp Met Glu Glu Lys Phe Gly Ile 
465                 470                 475                 480 


Thr Leu Gln Lys Ala His Pro Leu Arg Ala Val Ala Thr Pro Leu 
                485                 490                 495 


<210>  108
<211>  1485
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  108
atggatttcg atttccttac gattgccatt ggatttcttt ttacaattac cttgtatcag       60

gctctgaatt ttttcagtcg taaatcgaaa aaccttccgc caggaccatc accgctgcct      120

ttgataggga atcttcattt gttaggtgac cagcctcata aatcgttggc caagcttgcg      180

aagaaacatg gtcctattat gggcttacaa ttgggccaag tgacgactat tgttgttacg      240

tctagcggca tggccaagga agttcttcaa aagcaggatt tagctttttc atcccgttct      300

attccaaatg cgatacatgc acatgatcag tacaagtact cagtgatttg gcttcctgtg      360

gcatcacggt ggcgtgggct gcgcaaagct ttgaattcca acatgttttc cggaaacaga      420

ctggatgcga accaacatct gcggtctcgc aaagtgcagg aattaattgc ctattgcaga      480

aaatcaagcc aaactggtga cgcaattgac gtagggcgag ccgcctttcg aacatctctt      540

aacctcctgt ctaacacgat gttttctaaa gacctcactg atccttactc cgattccgcg      600

aaagaattca aggatttggt ctggaacgtg atggttgagg cgggaaaacc taacttggtg      660

gattattttc cgctccttga taaagtggac ccgcaaggaa ttcggaagcg catgacgatc      720

cattttggta aaattctcga gctttttggc ggattaattg atgaacgtct tcagcaaaaa      780

aaggcgaagg gagtgaacga cgacgttctt gacgtgcttc tgacgacctc tgaggaatcc      840

ccagaagaga ttgatcggac tcatattcag cgtatgtgcc tggatttgtt tgtggccggt      900

acggacacta cctcctccac gctcgaatgg gcaatgtcgg aaatgttaaa aaatcctgag      960

aaaatgaaag cggctcaagc agaactggcc caagtcatcg gcaaaggcaa agccgtagaa     1020

gaagccgatc ttgctcgctt gccgtattta cggtgcgcaa ttaaagaaac cctgagaatc     1080

catccgcctg tcccgctttt aatccctcga agaacagaac aagaggtcga agtctgtgga     1140

tataccgtgc ctaaaaattc acaagtgctc gtaaacgtct gggcgattag tcgtgacgac     1200

gcgatatgga aagacccgct tagttttaaa ccggaacggt tcctcgagag cgagttagaa     1260

atgcggggta aggatttcga gctgattcct ttcggggcgg gtagaagaat ctgccctggc     1320

ctgccgctgg cggtgcggat ggttccagtt atgcttggtt ctctgcttaa ttcattcgat     1380

tggaaactgg agggtggaat cgcgccgaag gacctggata tggaggagaa atttggaatt     1440

actttacaga aggcgcatcc tcttcgcgca gttgccacgc ctctc                     1485


<210>  109
<211>  1485
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  109
atggattttg attttttaac cattgcaatt ggttttttat tcaccattac gttgtatcaa       60

gcgttaaatt ttttttctag gaagtccaaa aaccttccgc caggtccttc tccactgcca      120

ctaatcggca acctacatct tttgggtgat cagcctcaca aatcattggc aaaattggcg      180

aagaaacacg gcccgattat gggtctacaa ctgggtcaag taacgaccat agttgtaaca      240

tctagtggca tggctaaaga agtacttcaa aagcaagatt tagctttttc ctcaagatct      300

ataccaaacg caatacatgc ccatgatcaa tacaagtaca gtgttatatg gctgccagtt      360

gcttccagat ggcgtgggct acgtaaagcg ctaaattcta acatgttctc tggcaataga      420

ttggacgcca accagcattt aagatctaga aaagtgcaag aattaattgc atactgtaga      480

aaatctagtc aaacagggga tgccatagat gtagggcgtg ctgcgtttag aaccagcttg      540

aatttattgt ctaacactat gttttcaaaa gacttgaccg atccctacag cgactccgca      600

aaggaattta aagatttagt ttggaacgtt atggtagagg ctggaaaacc gaatttggtg      660

gattattttc ccttgttgga taaggtcgac ccccagggta ttagaaagag aatgacaatt      720

cacttcggaa agatattgga actgtttggt ggattgatag acgaacgttt acaacaaaag      780

aaagccaaag gtgtgaatga tgatgtgctt gatgttttgc taactacaag cgaggaaagt      840

ccggaagaaa tagataggac ccatatccaa aggatgtgtt tggacttgtt tgttgccgga      900

actgatacca ctagttcaac attagaatgg gctatgtctg agatgttgaa aaatcctgag      960

aaaatgaaag ctgcacaggc agagttggcg caagtgatag gtaaaggtaa agctgtagag     1020

gaagcggatt tggctagatt accctatttg aggtgtgcta tcaaggaaac tcttaggatt     1080

catcctccag taccactatt aattccacgt agaaccgaac aggaagtgga agtgtgtgga     1140

tataccgtac cgaagaactc tcaagtgctg gtaaatgtgt gggccatttc tagagatgat     1200

gctatatgga aagacccatt atcttttaaa cccgagaggt ttctggaaag cgagttggaa     1260

atgagaggca aagactttga attgatccca tttggggcgg ggagaagaat ctgtcctgga     1320

ttgccgttgg cagtgagaat ggttccagtt atgctgggtt ctctgttgaa cagtttcgat     1380

tggaagttag agggagggat agcccctaaa gatctggaca tggaagaaaa gtttggcatt     1440

actcttcaaa aagcccatcc actaagggcc gtagctacac cgctg                     1485


<210>  110
<211>  1485
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  110
atggatttcg atttcctgac cattgcaatc ggctttcttt ttaccattac tctttaccag       60

gctcttaact tcttctctcg aaagtctaag aacctccctc ctggaccttc ccccctgccc      120

ctgatcggaa accttcacct cctcggcgac cagccccaca agtccctggc taagcttgct      180

aaaaagcacg gccccatcat gggtcttcag ctgggacagg ttacaactat tgttgttacc      240

agctccggaa tggctaagga ggtgctccag aaacaggacc ttgccttctc ctcgagatcc      300

atccccaacg ccatccatgc ccacgatcag tacaagtact ctgttatttg gctccctgtg      360

gcctctcgtt ggcgaggtct ccgaaaagct ctgaattcca acatgttcag cggtaaccgt      420

ctggacgcaa atcagcatct ccggtctaga aaggttcagg agctgattgc ttactgtcga      480

aagtcttcgc agacaggtga cgctatcgat gtgggtagag cagccttccg aacttcgctg      540

aacctcctct cgaataccat gttctctaag gatcttaccg atccatacag cgattctgcc      600

aaggagttta aggacctggt ttggaacgtc atggtcgagg caggtaagcc taacctggtt      660

gattactttc ccctgcttga taaagtggac cctcagggaa ttcgaaagag aatgaccatt      720

cattttggta agatcctcga gctgttcggt ggccttatcg acgagcgact ccagcagaaa      780

aaggccaagg gtgttaacga cgacgttctc gacgtgctgc tgacgacatc tgaggagtcc      840

cccgaggaaa ttgaccgaac ccatatccaa agaatgtgtc tggacctctt tgtcgctggt      900

actgacacca cttcctccac actggagtgg gcaatgtcgg aaatgctcaa gaaccctgag      960

aagatgaagg ctgcccaggc cgagcttgcc caggtcatcg gcaagggtaa ggccgtggaa     1020

gaggccgacc tcgctcgact gccctacctt cgatgtgcta tcaaggagac gctgagaatc     1080

cacccccctg tgcccctcct catcccccgt cgaaccgagc aggaagttga ggtctgtggc     1140

tacaccgtcc caaagaactc ccaggttctc gttaacgtgt gggctatttc cagagatgac     1200

gccatctgga aggaccctct gtcttttaag cctgagcgat tcctggagtc cgagctggag     1260

atgcggggaa aggactttga actgatcccc tttggagctg gacgacgaat ctgccccggt     1320

ctccccctgg ccgtccgaat ggtccccgtc atgcttggat cgctcctcaa ctcgtttgac     1380

tggaagcttg aaggcggaat tgctcccaag gaccttgata tggaagagaa gttcggtatc     1440

actctgcaga aagcacaccc cctccgggca gtcgccactc ctctg                     1485


<210>  111
<211>  864
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  111
atgacagcag ataacaattc catgcctcac ggtgctgtgt cttcatacgc gaaactggtg       60

cagaaccaaa cacctgagga tattctcgag gaattccccg aaatcatccc tctccagcag      120

cgcccgaaca cccgctcctc tgaaacctct aatgacgaat ccggcgagac atgtttctcc      180

ggccacgacg aagagcaaat taagctgatg aacgaaaatt gcatcgtgtt ggactgggat      240

gacaacgcca ttggagccgg taccaaaaag gtgtgccatc tgatggagaa cattgaaaag      300

ggactgctcc atcgagcttt ctcagtgttc attttcaatg aacagggtga gctcctgctg      360

caacagcgcg caacggaaaa gattaccttc cccgacctct ggactaacac ctgctgctca      420

cacccattgt gtatcgatga cgaacttggc ttgaagggca agcttgatga taagattaag      480

ggcgcaatca cggccgctgt tcgtaaactc gatcacgaac ttggaattcc tgaagacgaa      540

accaagactc gcggcaaatt tcacttcttg aatcgtatcc actatatggc gccttccaac      600

gagccttggg gcgagcacga gatcgactat attttgttct acaagatcaa tgcaaaggag      660

aacctgactg tgaacccgaa tgtgaatgaa gtgcgtgact tcaagtgggt ctcaccgaac      720

gatctgaaga ccatgtttgc cgatccatcc tacaaattca ccccgtggtt caaaattatc      780

tgtgaaaact atctgttcaa ttggtgggaa caactcgacg atttgtccga ggtcgagaac      840

gatcgtcaaa tccaccgtat gctt                                             864


<210>  112
<211>  1485
<212>  DNA
<213>  Artificial

<220>
<223>  mutated and/or codon-optimized sequence

<400>  112
atggattttg atttcttgac aatcgcaatt ggtttcctgt tcaccattac cttgtaccaa       60

gcgctcaact tctttagccg caaatccaag aacctcccac caggtccgag ccccctcccg      120

cttattggca acctgcactt gctgggagat cagccgcaca aatcattggc gaagctcgct      180

aagaagcacg gtccaattat gggtctgcag ttgggccaag ttacaactat cgtcgtgacc      240

tcgtccggaa tggcaaagga ggttttgcaa aaacaagatt tggctttctc gtcccgctcc      300

atccccaacg ctatccacgc acacgaccag tacaagtaca gcgtgatttg gctgcccgtt      360

gctagccgct ggcgcggatt gcgcaaggca ctgaattcca acatgttctc tggcaaccgc      420

ttggacgcca accaacacct tcgatcccgc aaagtgcaag aactgatcgc ttactgtcgc      480

aaaagctctc agaccggcga tgccattgac gtaggccgcg cggcatttcg aacctcgctc      540

aaccttctct cgaacacgat gttttcaaaa gaccttaccg acccatattc agattccgcc      600

aaggagttca aggaccttgt ttggaacgtg atggtcgaag ccggcaagcc gaatcttgtc      660

gattactttc cgttgctcga taaggtggat ccccagggaa tccgcaagcg tatgaccatc      720

cacttcggaa aaatcctgga gctgttcggt ggcctgatcg acgagcgcct tcaacagaag      780

aaggccaagg gagttaatga cgacgtgctg gatgtgcttc tcaccacctc tgaagagtcc      840

cctgaggaga tcgatcgtac acacatccag cgcatgtgtc ttgatttgtt cgtggctgga      900

acagatacca caagctcaac cttggagtgg gcaatgtcgg agatgcttaa gaacccggaa      960

aagatgaagg ctgcacaggc ggaactggcc caggtaatcg gcaagggtaa ggcagtagaa     1020

gaggctgacc tcgcacgact cccatatctc cgttgtgcta tcaaggagac cctgcgtatt     1080

cacccgccgg tccctcttct tattcctcgc cgcaccgagc aggaggttga agtgtgtggt     1140

tacactgtgc ccaaaaactc ccaagtgctg gtcaacgttt gggcgatctc gcgcgatgac     1200

gccatctgga aagacccttt gtccttcaag ccagagcgtt ttttggaatc cgagctggag     1260

atgcgtggaa aggattttga attgatcccg ttcggtgccg gtcgtcgcat ctgcccgggt     1320

cttccccttg cagtacgcat ggtcccggta atgctgggct cgctcctgaa ctcttttgat     1380

tggaaacttg agggcggtat cgctccaaag gacttggata tggaagaaaa gttcggaatt     1440

actttgcaaa aagcacaccc gttgcgcgca gtcgcaaccc ctctg                     1485


