                         SEQUENCE LISTING

<110>  Klotho Therapeutics Inc.
       TARSIO, Joseph F.
 
<120>  Therapeutic Recombinant Klotho Protein and Compositions and 
       Methods Involving the Same

<130>  20780.2a

<160>  152   

<170>  PatentIn version 3.5

<210>  1
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys 
    1010         


<210>  2
<211>  981
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser 
            980     


<210>  3
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys 
    530                 535                 540                 


Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met 
545                 550                 555                 560 


His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro 
                565                 570                 575     


Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg 
            580                 585                 590         


Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala 
        595                 600                 605             


Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala 
    610                 615                 620                 


Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu 
625                 630                 635                 640 


Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp 
                645                 650                 655     


Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly 
            660                 665                 670         


His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu 
        675                 680                 685             


Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala 
    690                 695                 700                 


Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val 
705                 710                 715                 720 


Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile 
                725                 730                 735     


Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln 
            740                 745                 750         


Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu 
        755                 760                 765             


Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile 
    770                 775                 780                 


Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu 
785                 790                 795                 800 


Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln 
                805                 810                 815     


Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys 
            820                 825                 830         


Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp 
        835                 840                 845             


Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln 
    850                 855                 860                 


Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn 
865                 870                 875                 880 


Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg 
                885                 890                 895     


Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser 
            900                 905                 910         


Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro 
        915                 920                 925             


Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu 
    930                 935                 940                 


Cys Ser Phe Phe His Thr Arg Lys Ser 
945                 950             


<210>  4
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser 
945             


<210>  5
<211>  946
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr 
            500                 505                 510         


Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Val 
        515                 520                 525             


Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln 
    530                 535                 540                 


Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg Phe 
545                 550                 555                 560 


Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val 
                565                 570                 575     


Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val 
            580                 585                 590         


Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro 
        595                 600                 605             


Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn 
    610                 615                 620                 


Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln 
625                 630                 635                 640 


Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr 
                645                 650                 655     


Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His 
            660                 665                 670         


Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn 
        675                 680                 685             


Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys 
    690                 695                 700                 


Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe 
705                 710                 715                 720 


Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro 
                725                 730                 735     


Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro 
            740                 745                 750         


Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe 
        755                 760                 765             


Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu 
    770                 775                 780                 


Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp 
785                 790                 795                 800 


Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly 
                805                 810                 815     


Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro 
            820                 825                 830         


Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala Glu Asp 
        835                 840                 845             


Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu 
    850                 855                 860                 


Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr 
865                 870                 875                 880 


Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala 
                885                 890                 895     


Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg Lys Ile 
            900                 905                 910         


Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe Cys 
        915                 920                 925             


Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His Thr Arg 
    930                 935                 940                 


Lys Ser 
945     


<210>  6
<211>  851
<212>  PRT
<213>  Homo sapiens

<400>  6

Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His 
1               5                   10                  15      


Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala 
            20                  25                  30          


Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu 
        35                  40                  45              


Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp 
    50                  55                  60                  


Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg 
65                  70                  75                  80  


Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His 
                85                  90                  95      


Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val 
            100                 105                 110         


Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg 
        115                 120                 125             


Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala 
    130                 135                 140                 


His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln 
145                 150                 155                 160 


Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg 
                165                 170                 175     


Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe 
            180                 185                 190         


Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro 
        195                 200                 205             


Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu 
    210                 215                 220                 


Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys 
225                 230                 235                 240 


Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe 
                245                 250                 255     


Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp 
            260                 265                 270         


Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe 
        275                 280                 285             


Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu 
    290                 295                 300                 


Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val 
305                 310                 315                 320 


Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp 
                325                 330                 335     


His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu 
            340                 345                 350         


Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln 
        355                 360                 365             


Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro 
    370                 375                 380                 


Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn 
385                 390                 395                 400 


Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val 
                405                 410                 415     


Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly 
            420                 425                 430         


Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile 
        435                 440                 445             


Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg 
    450                 455                 460                 


Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln 
465                 470                 475                 480 


Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu 
                485                 490                 495     


Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala 
            500                 505                 510         


Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu 
        515                 520                 525             


Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe 
    530                 535                 540                 


Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro 
545                 550                 555                 560 


Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala 
                565                 570                 575     


His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln 
            580                 585                 590         


Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala 
        595                 600                 605             


Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu 
    610                 615                 620                 


Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr 
625                 630                 635                 640 


Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu 
                645                 650                 655     


Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp 
            660                 665                 670         


Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys 
        675                 680                 685             


Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr 
    690                 695                 700                 


Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp 
705                 710                 715                 720 


Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu 
                725                 730                 735     


Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala Glu 
            740                 745                 750         


Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala 
        755                 760                 765             


Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala 
    770                 775                 780                 


Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr 
785                 790                 795                 800 


Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg Lys 
                805                 810                 815     


Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe 
            820                 825                 830         


Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His Thr 
        835                 840                 845             


Arg Lys Ser 
    850     


<210>  7
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp 
545                 


<210>  8
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp 
        515                 520     


<210>  9
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  9

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp 
        515     


<210>  10
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr 
            500                 505                 510         


Leu Trp 
        


<210>  11
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  11

Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His 
1               5                   10                  15      


Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala 
            20                  25                  30          


Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu 
        35                  40                  45              


Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp 
    50                  55                  60                  


Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg 
65                  70                  75                  80  


Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His 
                85                  90                  95      


Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val 
            100                 105                 110         


Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg 
        115                 120                 125             


Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala 
    130                 135                 140                 


His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln 
145                 150                 155                 160 


Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg 
                165                 170                 175     


Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe 
            180                 185                 190         


Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro 
        195                 200                 205             


Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu 
    210                 215                 220                 


Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys 
225                 230                 235                 240 


Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe 
                245                 250                 255     


Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp 
            260                 265                 270         


Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe 
        275                 280                 285             


Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu 
    290                 295                 300                 


Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val 
305                 310                 315                 320 


Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp 
                325                 330                 335     


His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu 
            340                 345                 350         


Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln 
        355                 360                 365             


Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro 
    370                 375                 380                 


Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn 
385                 390                 395                 400 


Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val 
                405                 410                 415     


Tyr Leu Trp 
            


<210>  12
<211>  981
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser 
            980     


<210>  13
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys 
    530                 535                 540                 


Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met 
545                 550                 555                 560 


His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro 
                565                 570                 575     


Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg 
            580                 585                 590         


Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala 
        595                 600                 605             


Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala 
    610                 615                 620                 


Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu 
625                 630                 635                 640 


Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp 
                645                 650                 655     


Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly 
            660                 665                 670         


His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu 
        675                 680                 685             


Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala 
    690                 695                 700                 


Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val 
705                 710                 715                 720 


Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile 
                725                 730                 735     


Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln 
            740                 745                 750         


Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu 
        755                 760                 765             


Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile 
    770                 775                 780                 


Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu 
785                 790                 795                 800 


Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln 
                805                 810                 815     


Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys 
            820                 825                 830         


Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp 
        835                 840                 845             


Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln 
    850                 855                 860                 


Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn 
865                 870                 875                 880 


Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg 
                885                 890                 895     


Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser 
            900                 905                 910         


Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro 
        915                 920                 925             


Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu 
    930                 935                 940                 


Cys Ser Phe Phe His Thr Arg Lys Ser 
945                 950             


<210>  14
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser 
945             


<210>  15
<211>  946
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr 
            500                 505                 510         


Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Val 
        515                 520                 525             


Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln 
    530                 535                 540                 


Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg Phe 
545                 550                 555                 560 


Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val 
                565                 570                 575     


Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val 
            580                 585                 590         


Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro 
        595                 600                 605             


Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn 
    610                 615                 620                 


Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln 
625                 630                 635                 640 


Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr 
                645                 650                 655     


Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His 
            660                 665                 670         


Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn 
        675                 680                 685             


Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys 
    690                 695                 700                 


Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe 
705                 710                 715                 720 


Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro 
                725                 730                 735     


Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro 
            740                 745                 750         


Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe 
        755                 760                 765             


Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu 
    770                 775                 780                 


Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp 
785                 790                 795                 800 


Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly 
                805                 810                 815     


Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro 
            820                 825                 830         


Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala Glu Asp 
        835                 840                 845             


Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu 
    850                 855                 860                 


Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr 
865                 870                 875                 880 


Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala 
                885                 890                 895     


Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg Lys Ile 
            900                 905                 910         


Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe Cys 
        915                 920                 925             


Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His Thr Arg 
    930                 935                 940                 


Lys Ser 
945     


<210>  16
<211>  851
<212>  PRT
<213>  Homo sapiens

<400>  16

Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His 
1               5                   10                  15      


Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala 
            20                  25                  30          


Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu 
        35                  40                  45              


Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp 
    50                  55                  60                  


Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg 
65                  70                  75                  80  


Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His 
                85                  90                  95      


Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val 
            100                 105                 110         


Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg 
        115                 120                 125             


Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala 
    130                 135                 140                 


His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln 
145                 150                 155                 160 


Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg 
                165                 170                 175     


Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe 
            180                 185                 190         


Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro 
        195                 200                 205             


Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu 
    210                 215                 220                 


Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser 
225                 230                 235                 240 


Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe 
                245                 250                 255     


Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp 
            260                 265                 270         


Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe 
        275                 280                 285             


Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu 
    290                 295                 300                 


Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val 
305                 310                 315                 320 


Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp 
                325                 330                 335     


His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu 
            340                 345                 350         


Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln 
        355                 360                 365             


Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro 
    370                 375                 380                 


Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn 
385                 390                 395                 400 


Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val 
                405                 410                 415     


Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly 
            420                 425                 430         


Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile 
        435                 440                 445             


Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg 
    450                 455                 460                 


Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln 
465                 470                 475                 480 


Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu 
                485                 490                 495     


Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala 
            500                 505                 510         


Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu 
        515                 520                 525             


Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe 
    530                 535                 540                 


Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro 
545                 550                 555                 560 


Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala 
                565                 570                 575     


His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln 
            580                 585                 590         


Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala 
        595                 600                 605             


Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu 
    610                 615                 620                 


Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr 
625                 630                 635                 640 


Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu 
                645                 650                 655     


Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp 
            660                 665                 670         


Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys 
        675                 680                 685             


Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr 
    690                 695                 700                 


Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp 
705                 710                 715                 720 


Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu 
                725                 730                 735     


Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala Glu 
            740                 745                 750         


Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala 
        755                 760                 765             


Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala 
    770                 775                 780                 


Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr 
785                 790                 795                 800 


Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg Lys 
                805                 810                 815     


Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe 
            820                 825                 830         


Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His Thr 
        835                 840                 845             


Arg Lys Ser 
    850     


<210>  17
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp 
545                 


<210>  18
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  18

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Phe Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp 
        515                 520     


<210>  19
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  19

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp 
        515     


<210>  20
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr 
            500                 505                 510         


Leu Trp 
        


<210>  21
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  21

Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His 
1               5                   10                  15      


Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala 
            20                  25                  30          


Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu 
        35                  40                  45              


Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp 
    50                  55                  60                  


Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg 
65                  70                  75                  80  


Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His 
                85                  90                  95      


Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val 
            100                 105                 110         


Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg 
        115                 120                 125             


Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala 
    130                 135                 140                 


His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln 
145                 150                 155                 160 


Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg 
                165                 170                 175     


Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe 
            180                 185                 190         


Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro 
        195                 200                 205             


Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu 
    210                 215                 220                 


Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser 
225                 230                 235                 240 


Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe 
                245                 250                 255     


Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp 
            260                 265                 270         


Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe 
        275                 280                 285             


Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu 
    290                 295                 300                 


Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val 
305                 310                 315                 320 


Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp 
                325                 330                 335     


His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu 
            340                 345                 350         


Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln 
        355                 360                 365             


Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro 
    370                 375                 380                 


Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn 
385                 390                 395                 400 


Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val 
                405                 410                 415     


Tyr Leu Trp 
            


<210>  22
<211>  1012
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys 
    1010         


<210>  23
<211>  981
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser 
            980     


<210>  24
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  24

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Val Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys 
    530                 535                 540                 


Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met 
545                 550                 555                 560 


His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro 
                565                 570                 575     


Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg 
            580                 585                 590         


Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala 
        595                 600                 605             


Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala 
    610                 615                 620                 


Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu 
625                 630                 635                 640 


Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp 
                645                 650                 655     


Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly 
            660                 665                 670         


His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu 
        675                 680                 685             


Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala 
    690                 695                 700                 


Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val 
705                 710                 715                 720 


Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile 
                725                 730                 735     


Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln 
            740                 745                 750         


Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu 
        755                 760                 765             


Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile 
    770                 775                 780                 


Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu 
785                 790                 795                 800 


Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln 
                805                 810                 815     


Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys 
            820                 825                 830         


Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp 
        835                 840                 845             


Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln 
    850                 855                 860                 


Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn 
865                 870                 875                 880 


Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg 
                885                 890                 895     


Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser 
            900                 905                 910         


Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro 
        915                 920                 925             


Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu 
    930                 935                 940                 


Cys Ser Phe Phe His Thr Arg Lys Ser 
945                 950             


<210>  25
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  25

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser 
945             


<210>  26
<211>  946
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr 
            500                 505                 510         


Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Val 
        515                 520                 525             


Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln 
    530                 535                 540                 


Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg Phe 
545                 550                 555                 560 


Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val 
                565                 570                 575     


Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val 
            580                 585                 590         


Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro 
        595                 600                 605             


Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn 
    610                 615                 620                 


Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln 
625                 630                 635                 640 


Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr 
                645                 650                 655     


Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His 
            660                 665                 670         


Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn 
        675                 680                 685             


Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys 
    690                 695                 700                 


Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe 
705                 710                 715                 720 


Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro 
                725                 730                 735     


Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro 
            740                 745                 750         


Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe 
        755                 760                 765             


Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu 
    770                 775                 780                 


Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp 
785                 790                 795                 800 


Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly 
                805                 810                 815     


Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro 
            820                 825                 830         


Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala Glu Asp 
        835                 840                 845             


Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu 
    850                 855                 860                 


Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr 
865                 870                 875                 880 


Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala 
                885                 890                 895     


Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg Lys Ile 
            900                 905                 910         


Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe Cys 
        915                 920                 925             


Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His Thr Arg 
    930                 935                 940                 


Lys Ser 
945     


<210>  27
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp 
545                 


<210>  28
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Val Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp 
        515                 520     


<210>  29
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  29

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp 
        515     


<210>  30
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  30

Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr 
            500                 505                 510         


Leu Trp 
        


<210>  31
<211>  981
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser 
            980     


<210>  32
<211>  953
<212>  PRT
<213>  Homo sapiens

<400>  32

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Val Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg 
        515                 520                 525             


Leu Ile Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys 
    530                 535                 540                 


Val Asp Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met 
545                 550                 555                 560 


His Val Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro 
                565                 570                 575     


Leu Gly Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg 
            580                 585                 590         


Cys Met Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala 
        595                 600                 605             


Leu Trp Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala 
    610                 615                 620                 


Arg Gln Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu 
625                 630                 635                 640 


Tyr Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp 
                645                 650                 655     


Ile Thr Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly 
            660                 665                 670         


His Asn Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu 
        675                 680                 685             


Lys Phe Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala 
    690                 695                 700                 


Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val 
705                 710                 715                 720 


Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile 
                725                 730                 735     


Phe Gly Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln 
            740                 745                 750         


Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu 
        755                 760                 765             


Ile Gln Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile 
    770                 775                 780                 


Leu Val Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu 
785                 790                 795                 800 


Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln 
                805                 810                 815     


Val Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys 
            820                 825                 830         


Phe Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp 
        835                 840                 845             


Asp Gly Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln 
    850                 855                 860                 


Asn Tyr Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn 
865                 870                 875                 880 


Leu Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg 
                885                 890                 895     


Phe Gly Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser 
            900                 905                 910         


Met Lys His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro 
        915                 920                 925             


Glu Thr Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu 
    930                 935                 940                 


Cys Ser Phe Phe His Thr Arg Lys Ser 
945                 950             


<210>  33
<211>  948
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser 
945             


<210>  34
<211>  946
<212>  PRT
<213>  Homo sapiens

<400>  34

Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr 
            500                 505                 510         


Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Val 
        515                 520                 525             


Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln 
    530                 535                 540                 


Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg Phe 
545                 550                 555                 560 


Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val 
                565                 570                 575     


Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val 
            580                 585                 590         


Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro 
        595                 600                 605             


Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn 
    610                 615                 620                 


Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln 
625                 630                 635                 640 


Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr 
                645                 650                 655     


Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His 
            660                 665                 670         


Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn 
        675                 680                 685             


Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys 
    690                 695                 700                 


Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe 
705                 710                 715                 720 


Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro 
                725                 730                 735     


Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro 
            740                 745                 750         


Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe 
        755                 760                 765             


Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu 
    770                 775                 780                 


Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp 
785                 790                 795                 800 


Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly 
                805                 810                 815     


Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro 
            820                 825                 830         


Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala Glu Asp 
        835                 840                 845             


Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu 
    850                 855                 860                 


Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr 
865                 870                 875                 880 


Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala 
                885                 890                 895     


Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg Lys Ile 
            900                 905                 910         


Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe Cys 
        915                 920                 925             


Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His Thr Arg 
    930                 935                 940                 


Lys Ser 
945     


<210>  35
<211>  549
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp 
545                 


<210>  36
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  36

Arg Arg Leu Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg 
1               5                   10                  15      


Val Ser Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr 
            20                  25                  30          


Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr 
        35                  40                  45              


Glu Gly Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr 
    50                  55                  60                  


Phe Thr His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser 
65                  70                  75                  80  


Leu Pro Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val 
                85                  90                  95      


Ala Ser Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg 
            100                 105                 110         


Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val 
        115                 120                 125             


Leu Pro Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr 
    130                 135                 140                 


Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val 
145                 150                 155                 160 


Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr 
                165                 170                 175     


Gly Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala 
            180                 185                 190         


Glu Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr 
        195                 200                 205             


Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg 
    210                 215                 220                 


Leu Ala Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala 
225                 230                 235                 240 


His Asn Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr 
                245                 250                 255     


Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser 
            260                 265                 270         


His Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys 
        275                 280                 285             


Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe 
    290                 295                 300                 


Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile 
305                 310                 315                 320 


Leu Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala 
                325                 330                 335     


Asp Phe Phe Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu 
            340                 345                 350         


Asp Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln 
        355                 360                 365             


Leu Leu Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile 
    370                 375                 380                 


Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala 
385                 390                 395                 400 


Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala 
                405                 410                 415     


Ile Lys Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu 
            420                 425                 430         


Met Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu 
        435                 440                 445             


Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser 
    450                 455                 460                 


Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro 
465                 470                 475                 480 


Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala 
                485                 490                 495     


Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln 
            500                 505                 510         


Phe Thr Asp Leu Asn Val Tyr Leu Trp 
        515                 520     


<210>  37
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  37

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp 
        515     


<210>  38
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  38

Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr 
            500                 505                 510         


Leu Trp 
        


<210>  39
<211>  1218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_Native_SS_34_981V_GS_IgG1_noCH1_Fc_Fusion

<400>  39

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
            980                 985                 990         


Lys Thr His Thr Cys Pro Pro Cys  Pro Ala Pro Glu Leu  Leu Gly Gly 
        995                 1000                 1005             


Pro Ser  Val Phe Leu Phe Pro  Pro Lys Pro Lys Asp  Thr Leu Met 
    1010                 1015                 1020             


Ile Ser  Arg Thr Pro Glu Val  Thr Cys Val Val Val  Asp Val Ser 
    1025                 1030                 1035             


His Glu  Asp Pro Glu Val Lys  Phe Asn Trp Tyr Val  Asp Gly Val 
    1040                 1045                 1050             


Glu Val  His Asn Ala Lys Thr  Lys Pro Arg Glu Glu  Gln Tyr Asn 
    1055                 1060                 1065             


Ser Thr  Tyr Arg Val Val Ser  Val Leu Thr Val Leu  His Gln Asp 
    1070                 1075                 1080             


Trp Leu  Asn Gly Lys Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Ala 
    1085                 1090                 1095             


Leu Pro  Ala Pro Ile Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln 
    1100                 1105                 1110             


Pro Arg  Glu Pro Gln Val Tyr  Thr Leu Pro Pro Ser  Arg Asp Glu 
    1115                 1120                 1125             


Leu Thr  Lys Asn Gln Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe 
    1130                 1135                 1140             


Tyr Pro  Ser Asp Ile Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro 
    1145                 1150                 1155             


Glu Asn  Asn Tyr Lys Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly 
    1160                 1165                 1170             


Ser Phe  Phe Leu Tyr Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp 
    1175                 1180                 1185             


Gln Gln  Gly Asn Val Phe Ser  Cys Ser Val Met His  Glu Ala Leu 
    1190                 1195                 1200             


His Asn  His Tyr Thr Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    1205                 1210                 1215             


<210>  40
<211>  1185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_981V_GS_IgG1_noCH1_Fc_Fusion

<400>  40

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
945                 950                 955                 960 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                965                 970                 975     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            980                 985                 990         


Arg Thr Pro Glu Val Thr Cys Val  Val Val Asp Val Ser  His Glu Asp 
        995                 1000                 1005             


Pro Glu  Val Lys Phe Asn Trp  Tyr Val Asp Gly Val  Glu Val His 
    1010                 1015                 1020             


Asn Ala  Lys Thr Lys Pro Arg  Glu Glu Gln Tyr Asn  Ser Thr Tyr 
    1025                 1030                 1035             


Arg Val  Val Ser Val Leu Thr  Val Leu His Gln Asp  Trp Leu Asn 
    1040                 1045                 1050             


Gly Lys  Glu Tyr Lys Cys Lys  Val Ser Asn Lys Ala  Leu Pro Ala 
    1055                 1060                 1065             


Pro Ile  Glu Lys Thr Ile Ser  Lys Ala Lys Gly Gln  Pro Arg Glu 
    1070                 1075                 1080             


Pro Gln  Val Tyr Thr Leu Pro  Pro Ser Arg Asp Glu  Leu Thr Lys 
    1085                 1090                 1095             


Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys Gly Phe  Tyr Pro Ser 
    1100                 1105                 1110             


Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly Gln Pro  Glu Asn Asn 
    1115                 1120                 1125             


Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe 
    1130                 1135                 1140             


Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly 
    1145                 1150                 1155             


Asn Val  Phe Ser Cys Ser Val  Met His Glu Ala Leu  His Asn His 
    1160                 1165                 1170             


Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro Gly Lys  
    1175                 1180                 1185 


<210>  41
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_Native_SS_34_549V_GS_IgG1_noCH1_Fc_Fusion

<400>  41

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu 
    530                 535                 540                 


Thr Lys Pro Tyr His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
545                 550                 555                 560 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                565                 570                 575     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            580                 585                 590         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        595                 600                 605             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    610                 615                 620                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
625                 630                 635                 640 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                645                 650                 655     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            660                 665                 670         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        675                 680                 685             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    690                 695                 700                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
705                 710                 715                 720 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                725                 730                 735     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            740                 745                 750         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        755                 760                 765             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    770                 775                 780                 


Gly Lys 
785     


<210>  42
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_549V_GS_IgG1_noCH1_Fc_Fusion

<400>  42

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr 
            500                 505                 510         


Lys Pro Tyr His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
        515                 520                 525             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    530                 535                 540                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
545                 550                 555                 560 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                565                 570                 575     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            580                 585                 590         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        595                 600                 605             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    610                 615                 620                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
625                 630                 635                 640 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                645                 650                 655     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            660                 665                 670         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        675                 680                 685             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    690                 695                 700                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
705                 710                 715                 720 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                725                 730                 735     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            740                 745                 750         


Lys 
    


<210>  43
<211>  1218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_Native_SS_34_981V_C370S_GS_IgG1_noCH1_Fc_Fusion

<400>  43

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
            980                 985                 990         


Lys Thr His Thr Cys Pro Pro Cys  Pro Ala Pro Glu Leu  Leu Gly Gly 
        995                 1000                 1005             


Pro Ser  Val Phe Leu Phe Pro  Pro Lys Pro Lys Asp  Thr Leu Met 
    1010                 1015                 1020             


Ile Ser  Arg Thr Pro Glu Val  Thr Cys Val Val Val  Asp Val Ser 
    1025                 1030                 1035             


His Glu  Asp Pro Glu Val Lys  Phe Asn Trp Tyr Val  Asp Gly Val 
    1040                 1045                 1050             


Glu Val  His Asn Ala Lys Thr  Lys Pro Arg Glu Glu  Gln Tyr Asn 
    1055                 1060                 1065             


Ser Thr  Tyr Arg Val Val Ser  Val Leu Thr Val Leu  His Gln Asp 
    1070                 1075                 1080             


Trp Leu  Asn Gly Lys Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Ala 
    1085                 1090                 1095             


Leu Pro  Ala Pro Ile Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln 
    1100                 1105                 1110             


Pro Arg  Glu Pro Gln Val Tyr  Thr Leu Pro Pro Ser  Arg Asp Glu 
    1115                 1120                 1125             


Leu Thr  Lys Asn Gln Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe 
    1130                 1135                 1140             


Tyr Pro  Ser Asp Ile Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro 
    1145                 1150                 1155             


Glu Asn  Asn Tyr Lys Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly 
    1160                 1165                 1170             


Ser Phe  Phe Leu Tyr Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp 
    1175                 1180                 1185             


Gln Gln  Gly Asn Val Phe Ser  Cys Ser Val Met His  Glu Ala Leu 
    1190                 1195                 1200             


His Asn  His Tyr Thr Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    1205                 1210                 1215             


<210>  44
<211>  1185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_981V_C370S_GS_IgG1_noCH1_Fc_Fusion

<400>  44

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
945                 950                 955                 960 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                965                 970                 975     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            980                 985                 990         


Arg Thr Pro Glu Val Thr Cys Val  Val Val Asp Val Ser  His Glu Asp 
        995                 1000                 1005             


Pro Glu  Val Lys Phe Asn Trp  Tyr Val Asp Gly Val  Glu Val His 
    1010                 1015                 1020             


Asn Ala  Lys Thr Lys Pro Arg  Glu Glu Gln Tyr Asn  Ser Thr Tyr 
    1025                 1030                 1035             


Arg Val  Val Ser Val Leu Thr  Val Leu His Gln Asp  Trp Leu Asn 
    1040                 1045                 1050             


Gly Lys  Glu Tyr Lys Cys Lys  Val Ser Asn Lys Ala  Leu Pro Ala 
    1055                 1060                 1065             


Pro Ile  Glu Lys Thr Ile Ser  Lys Ala Lys Gly Gln  Pro Arg Glu 
    1070                 1075                 1080             


Pro Gln  Val Tyr Thr Leu Pro  Pro Ser Arg Asp Glu  Leu Thr Lys 
    1085                 1090                 1095             


Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys Gly Phe  Tyr Pro Ser 
    1100                 1105                 1110             


Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly Gln Pro  Glu Asn Asn 
    1115                 1120                 1125             


Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe 
    1130                 1135                 1140             


Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly 
    1145                 1150                 1155             


Asn Val  Phe Ser Cys Ser Val  Met His Glu Ala Leu  His Asn His 
    1160                 1165                 1170             


Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro Gly Lys  
    1175                 1180                 1185 


<210>  45
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_Native_SS_34_549V_C370S_GS_IgG1_noCH1_Fc_Fusion

<400>  45

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu 
    530                 535                 540                 


Thr Lys Pro Tyr His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
545                 550                 555                 560 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                565                 570                 575     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            580                 585                 590         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        595                 600                 605             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    610                 615                 620                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
625                 630                 635                 640 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                645                 650                 655     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            660                 665                 670         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        675                 680                 685             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    690                 695                 700                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
705                 710                 715                 720 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                725                 730                 735     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            740                 745                 750         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        755                 760                 765             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    770                 775                 780                 


Gly Lys 
785     


<210>  46
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_549V_C370S_GS_IgG1_noCH1_Fc_Fusion

<400>  46

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr 
            500                 505                 510         


Lys Pro Tyr His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
        515                 520                 525             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    530                 535                 540                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
545                 550                 555                 560 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                565                 570                 575     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            580                 585                 590         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        595                 600                 605             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    610                 615                 620                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
625                 630                 635                 640 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                645                 650                 655     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            660                 665                 670         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        675                 680                 685             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    690                 695                 700                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
705                 710                 715                 720 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                725                 730                 735     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            740                 745                 750         


Lys 
    


<210>  47
<211>  1183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_36_981V_GS_IgG1_noCH1_Fc_Fusion

<400>  47

Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr 
            500                 505                 510         


Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Val 
        515                 520                 525             


Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln 
    530                 535                 540                 


Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg Phe 
545                 550                 555                 560 


Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val 
                565                 570                 575     


Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val 
            580                 585                 590         


Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro 
        595                 600                 605             


Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn 
    610                 615                 620                 


Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln 
625                 630                 635                 640 


Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr 
                645                 650                 655     


Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His 
            660                 665                 670         


Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn 
        675                 680                 685             


Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys 
    690                 695                 700                 


Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe 
705                 710                 715                 720 


Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro 
                725                 730                 735     


Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro 
            740                 745                 750         


Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe 
        755                 760                 765             


Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu 
    770                 775                 780                 


Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp 
785                 790                 795                 800 


Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly 
                805                 810                 815     


Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro 
            820                 825                 830         


Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala Glu Asp 
        835                 840                 845             


Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu 
    850                 855                 860                 


Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr 
865                 870                 875                 880 


Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala 
                885                 890                 895     


Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg Lys Ile 
            900                 905                 910         


Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe Cys 
        915                 920                 925             


Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His Thr Arg 
    930                 935                 940                 


Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His 
945                 950                 955                 960 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                965                 970                 975     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            980                 985                 990         


Pro Glu Val Thr Cys Val Val Val  Asp Val Ser His Glu  Asp Pro Glu 
        995                 1000                 1005             


Val Lys  Phe Asn Trp Tyr Val  Asp Gly Val Glu Val  His Asn Ala 
    1010                 1015                 1020             


Lys Thr  Lys Pro Arg Glu Glu  Gln Tyr Asn Ser Thr  Tyr Arg Val 
    1025                 1030                 1035             


Val Ser  Val Leu Thr Val Leu  His Gln Asp Trp Leu  Asn Gly Lys 
    1040                 1045                 1050             


Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Ala Leu Pro  Ala Pro Ile 
    1055                 1060                 1065             


Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln 
    1070                 1075                 1080             


Val Tyr  Thr Leu Pro Pro Ser  Arg Asp Glu Leu Thr  Lys Asn Gln 
    1085                 1090                 1095             


Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile 
    1100                 1105                 1110             


Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 
    1115                 1120                 1125             


Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 
    1130                 1135                 1140             


Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val 
    1145                 1150                 1155             


Phe Ser  Cys Ser Val Met His  Glu Ala Leu His Asn  His Tyr Thr 
    1160                 1165                 1170             


Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    1175                 1180             


<210>  48
<211>  1183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_36_981V_C370S_GS_IgG1_noCH1_Fc_Fusion

<400>  48

Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr 
            500                 505                 510         


Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Val 
        515                 520                 525             


Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln 
    530                 535                 540                 


Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg Phe 
545                 550                 555                 560 


Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val 
                565                 570                 575     


Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val 
            580                 585                 590         


Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro 
        595                 600                 605             


Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn 
    610                 615                 620                 


Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln 
625                 630                 635                 640 


Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr 
                645                 650                 655     


Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His 
            660                 665                 670         


Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn 
        675                 680                 685             


Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys 
    690                 695                 700                 


Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe 
705                 710                 715                 720 


Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro 
                725                 730                 735     


Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro 
            740                 745                 750         


Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe 
        755                 760                 765             


Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu 
    770                 775                 780                 


Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp 
785                 790                 795                 800 


Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly 
                805                 810                 815     


Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro 
            820                 825                 830         


Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala Glu Asp 
        835                 840                 845             


Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu 
    850                 855                 860                 


Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr 
865                 870                 875                 880 


Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala 
                885                 890                 895     


Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg Lys Ile 
            900                 905                 910         


Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe Cys 
        915                 920                 925             


Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His Thr Arg 
    930                 935                 940                 


Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His 
945                 950                 955                 960 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                965                 970                 975     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            980                 985                 990         


Pro Glu Val Thr Cys Val Val Val  Asp Val Ser His Glu  Asp Pro Glu 
        995                 1000                 1005             


Val Lys  Phe Asn Trp Tyr Val  Asp Gly Val Glu Val  His Asn Ala 
    1010                 1015                 1020             


Lys Thr  Lys Pro Arg Glu Glu  Gln Tyr Asn Ser Thr  Tyr Arg Val 
    1025                 1030                 1035             


Val Ser  Val Leu Thr Val Leu  His Gln Asp Trp Leu  Asn Gly Lys 
    1040                 1045                 1050             


Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Ala Leu Pro  Ala Pro Ile 
    1055                 1060                 1065             


Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln 
    1070                 1075                 1080             


Val Tyr  Thr Leu Pro Pro Ser  Arg Asp Glu Leu Thr  Lys Asn Gln 
    1085                 1090                 1095             


Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile 
    1100                 1105                 1110             


Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 
    1115                 1120                 1125             


Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 
    1130                 1135                 1140             


Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val 
    1145                 1150                 1155             


Phe Ser  Cys Ser Val Met His  Glu Ala Leu His Asn  His Tyr Thr 
    1160                 1165                 1170             


Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    1175                 1180             


<210>  49
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_36_549V_GS_IgG1_noCH1_Fc_Fusion

<400>  49

Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr Lys Pro 
            500                 505                 510         


Tyr His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His 
        515                 520                 525             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    530                 535                 540                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
545                 550                 555                 560 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                565                 570                 575     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            580                 585                 590         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        595                 600                 605             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    610                 615                 620                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
625                 630                 635                 640 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                645                 650                 655     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            660                 665                 670         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        675                 680                 685             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    690                 695                 700                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
705                 710                 715                 720 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                725                 730                 735     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745                 750     


<210>  50
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_36_549V_C370S_GS_IgG1_noCH1_Fc_Fusion

<400>  50

Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr Lys Pro 
            500                 505                 510         


Tyr His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His 
        515                 520                 525             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    530                 535                 540                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
545                 550                 555                 560 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                565                 570                 575     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            580                 585                 590         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        595                 600                 605             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    610                 615                 620                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
625                 630                 635                 640 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                645                 650                 655     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            660                 665                 670         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        675                 680                 685             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    690                 695                 700                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
705                 710                 715                 720 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                725                 730                 735     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745                 750     


<210>  51
<211>  1218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_Native_SS_34_981F_GS_IgG1_noCH1_Fc_Fusion

<400>  51

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
            980                 985                 990         


Lys Thr His Thr Cys Pro Pro Cys  Pro Ala Pro Glu Leu  Leu Gly Gly 
        995                 1000                 1005             


Pro Ser  Val Phe Leu Phe Pro  Pro Lys Pro Lys Asp  Thr Leu Met 
    1010                 1015                 1020             


Ile Ser  Arg Thr Pro Glu Val  Thr Cys Val Val Val  Asp Val Ser 
    1025                 1030                 1035             


His Glu  Asp Pro Glu Val Lys  Phe Asn Trp Tyr Val  Asp Gly Val 
    1040                 1045                 1050             


Glu Val  His Asn Ala Lys Thr  Lys Pro Arg Glu Glu  Gln Tyr Asn 
    1055                 1060                 1065             


Ser Thr  Tyr Arg Val Val Ser  Val Leu Thr Val Leu  His Gln Asp 
    1070                 1075                 1080             


Trp Leu  Asn Gly Lys Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Ala 
    1085                 1090                 1095             


Leu Pro  Ala Pro Ile Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln 
    1100                 1105                 1110             


Pro Arg  Glu Pro Gln Val Tyr  Thr Leu Pro Pro Ser  Arg Asp Glu 
    1115                 1120                 1125             


Leu Thr  Lys Asn Gln Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe 
    1130                 1135                 1140             


Tyr Pro  Ser Asp Ile Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro 
    1145                 1150                 1155             


Glu Asn  Asn Tyr Lys Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly 
    1160                 1165                 1170             


Ser Phe  Phe Leu Tyr Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp 
    1175                 1180                 1185             


Gln Gln  Gly Asn Val Phe Ser  Cys Ser Val Met His  Glu Ala Leu 
    1190                 1195                 1200             


His Asn  His Tyr Thr Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    1205                 1210                 1215             


<210>  52
<211>  1185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_981F_GS_IgG1_noCH1_Fc_Fusion

<400>  52

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
945                 950                 955                 960 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                965                 970                 975     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            980                 985                 990         


Arg Thr Pro Glu Val Thr Cys Val  Val Val Asp Val Ser  His Glu Asp 
        995                 1000                 1005             


Pro Glu  Val Lys Phe Asn Trp  Tyr Val Asp Gly Val  Glu Val His 
    1010                 1015                 1020             


Asn Ala  Lys Thr Lys Pro Arg  Glu Glu Gln Tyr Asn  Ser Thr Tyr 
    1025                 1030                 1035             


Arg Val  Val Ser Val Leu Thr  Val Leu His Gln Asp  Trp Leu Asn 
    1040                 1045                 1050             


Gly Lys  Glu Tyr Lys Cys Lys  Val Ser Asn Lys Ala  Leu Pro Ala 
    1055                 1060                 1065             


Pro Ile  Glu Lys Thr Ile Ser  Lys Ala Lys Gly Gln  Pro Arg Glu 
    1070                 1075                 1080             


Pro Gln  Val Tyr Thr Leu Pro  Pro Ser Arg Asp Glu  Leu Thr Lys 
    1085                 1090                 1095             


Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys Gly Phe  Tyr Pro Ser 
    1100                 1105                 1110             


Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly Gln Pro  Glu Asn Asn 
    1115                 1120                 1125             


Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe 
    1130                 1135                 1140             


Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly 
    1145                 1150                 1155             


Asn Val  Phe Ser Cys Ser Val  Met His Glu Ala Leu  His Asn His 
    1160                 1165                 1170             


Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro Gly Lys  
    1175                 1180                 1185 


<210>  53
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_Native_SS_34_549F_GS_IgG1_noCH1_Fc_Fusion

<400>  53

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu 
    530                 535                 540                 


Thr Lys Pro Tyr His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
545                 550                 555                 560 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                565                 570                 575     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            580                 585                 590         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        595                 600                 605             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    610                 615                 620                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
625                 630                 635                 640 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                645                 650                 655     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            660                 665                 670         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        675                 680                 685             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    690                 695                 700                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
705                 710                 715                 720 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                725                 730                 735     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            740                 745                 750         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        755                 760                 765             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    770                 775                 780                 


Gly Lys 
785     


<210>  54
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_549F_GS_IgG1_noCH1_Fc_Fusion

<400>  54

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr 
            500                 505                 510         


Lys Pro Tyr His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
        515                 520                 525             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    530                 535                 540                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
545                 550                 555                 560 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                565                 570                 575     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            580                 585                 590         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        595                 600                 605             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    610                 615                 620                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
625                 630                 635                 640 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                645                 650                 655     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            660                 665                 670         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        675                 680                 685             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    690                 695                 700                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
705                 710                 715                 720 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                725                 730                 735     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            740                 745                 750         


Lys 
    


<210>  55
<211>  1218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_Native_SS_34_981F_C370S_GS_IgG1_noCH1_Fc_Fusion

<400>  55

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
            980                 985                 990         


Lys Thr His Thr Cys Pro Pro Cys  Pro Ala Pro Glu Leu  Leu Gly Gly 
        995                 1000                 1005             


Pro Ser  Val Phe Leu Phe Pro  Pro Lys Pro Lys Asp  Thr Leu Met 
    1010                 1015                 1020             


Ile Ser  Arg Thr Pro Glu Val  Thr Cys Val Val Val  Asp Val Ser 
    1025                 1030                 1035             


His Glu  Asp Pro Glu Val Lys  Phe Asn Trp Tyr Val  Asp Gly Val 
    1040                 1045                 1050             


Glu Val  His Asn Ala Lys Thr  Lys Pro Arg Glu Glu  Gln Tyr Asn 
    1055                 1060                 1065             


Ser Thr  Tyr Arg Val Val Ser  Val Leu Thr Val Leu  His Gln Asp 
    1070                 1075                 1080             


Trp Leu  Asn Gly Lys Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Ala 
    1085                 1090                 1095             


Leu Pro  Ala Pro Ile Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln 
    1100                 1105                 1110             


Pro Arg  Glu Pro Gln Val Tyr  Thr Leu Pro Pro Ser  Arg Asp Glu 
    1115                 1120                 1125             


Leu Thr  Lys Asn Gln Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe 
    1130                 1135                 1140             


Tyr Pro  Ser Asp Ile Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro 
    1145                 1150                 1155             


Glu Asn  Asn Tyr Lys Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly 
    1160                 1165                 1170             


Ser Phe  Phe Leu Tyr Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp 
    1175                 1180                 1185             


Gln Gln  Gly Asn Val Phe Ser  Cys Ser Val Met His  Glu Ala Leu 
    1190                 1195                 1200             


His Asn  His Tyr Thr Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    1205                 1210                 1215             


<210>  56
<211>  1185
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_981F_C370S_GS_IgG1_noCH1_Fc_Fusion

<400>  56

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
945                 950                 955                 960 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                965                 970                 975     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            980                 985                 990         


Arg Thr Pro Glu Val Thr Cys Val  Val Val Asp Val Ser  His Glu Asp 
        995                 1000                 1005             


Pro Glu  Val Lys Phe Asn Trp  Tyr Val Asp Gly Val  Glu Val His 
    1010                 1015                 1020             


Asn Ala  Lys Thr Lys Pro Arg  Glu Glu Gln Tyr Asn  Ser Thr Tyr 
    1025                 1030                 1035             


Arg Val  Val Ser Val Leu Thr  Val Leu His Gln Asp  Trp Leu Asn 
    1040                 1045                 1050             


Gly Lys  Glu Tyr Lys Cys Lys  Val Ser Asn Lys Ala  Leu Pro Ala 
    1055                 1060                 1065             


Pro Ile  Glu Lys Thr Ile Ser  Lys Ala Lys Gly Gln  Pro Arg Glu 
    1070                 1075                 1080             


Pro Gln  Val Tyr Thr Leu Pro  Pro Ser Arg Asp Glu  Leu Thr Lys 
    1085                 1090                 1095             


Asn Gln  Val Ser Leu Thr Cys  Leu Val Lys Gly Phe  Tyr Pro Ser 
    1100                 1105                 1110             


Asp Ile  Ala Val Glu Trp Glu  Ser Asn Gly Gln Pro  Glu Asn Asn 
    1115                 1120                 1125             


Tyr Lys  Thr Thr Pro Pro Val  Leu Asp Ser Asp Gly  Ser Phe Phe 
    1130                 1135                 1140             


Leu Tyr  Ser Lys Leu Thr Val  Asp Lys Ser Arg Trp  Gln Gln Gly 
    1145                 1150                 1155             


Asn Val  Phe Ser Cys Ser Val  Met His Glu Ala Leu  His Asn His 
    1160                 1165                 1170             


Tyr Thr  Gln Lys Ser Leu Ser  Leu Ser Pro Gly Lys  
    1175                 1180                 1185 


<210>  57
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_Native_SS_34_549F_C370S_GS_IgG1_noCH1_Fc_Fusion

<400>  57

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu 
    530                 535                 540                 


Thr Lys Pro Tyr His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp 
545                 550                 555                 560 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
                565                 570                 575     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            580                 585                 590         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        595                 600                 605             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    610                 615                 620                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
625                 630                 635                 640 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                645                 650                 655     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            660                 665                 670         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        675                 680                 685             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    690                 695                 700                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
705                 710                 715                 720 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                725                 730                 735     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            740                 745                 750         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        755                 760                 765             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    770                 775                 780                 


Gly Lys 
785     


<210>  58
<211>  753
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_549F_C370S_GS_IgG1_noCH1_Fc_Fusion

<400>  58

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr 
            500                 505                 510         


Lys Pro Tyr His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys 
        515                 520                 525             


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
    530                 535                 540                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
545                 550                 555                 560 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
                565                 570                 575     


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            580                 585                 590         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
        595                 600                 605             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    610                 615                 620                 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
625                 630                 635                 640 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                645                 650                 655     


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
            660                 665                 670         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        675                 680                 685             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    690                 695                 700                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
705                 710                 715                 720 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                725                 730                 735     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            740                 745                 750         


Lys 
    


<210>  59
<211>  1183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_36_981F_GS_IgG1_noCH1_Fc_Fusion

<400>  59

Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr 
            500                 505                 510         


Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Val 
        515                 520                 525             


Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln 
    530                 535                 540                 


Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg Phe 
545                 550                 555                 560 


Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val 
                565                 570                 575     


Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val 
            580                 585                 590         


Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro 
        595                 600                 605             


Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn 
    610                 615                 620                 


Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln 
625                 630                 635                 640 


Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr 
                645                 650                 655     


Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His 
            660                 665                 670         


Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn 
        675                 680                 685             


Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys 
    690                 695                 700                 


Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe 
705                 710                 715                 720 


Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro 
                725                 730                 735     


Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro 
            740                 745                 750         


Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe 
        755                 760                 765             


Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu 
    770                 775                 780                 


Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp 
785                 790                 795                 800 


Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly 
                805                 810                 815     


Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro 
            820                 825                 830         


Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala Glu Asp 
        835                 840                 845             


Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu 
    850                 855                 860                 


Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr 
865                 870                 875                 880 


Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala 
                885                 890                 895     


Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg Lys Ile 
            900                 905                 910         


Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe Cys 
        915                 920                 925             


Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His Thr Arg 
    930                 935                 940                 


Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His 
945                 950                 955                 960 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                965                 970                 975     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            980                 985                 990         


Pro Glu Val Thr Cys Val Val Val  Asp Val Ser His Glu  Asp Pro Glu 
        995                 1000                 1005             


Val Lys  Phe Asn Trp Tyr Val  Asp Gly Val Glu Val  His Asn Ala 
    1010                 1015                 1020             


Lys Thr  Lys Pro Arg Glu Glu  Gln Tyr Asn Ser Thr  Tyr Arg Val 
    1025                 1030                 1035             


Val Ser  Val Leu Thr Val Leu  His Gln Asp Trp Leu  Asn Gly Lys 
    1040                 1045                 1050             


Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Ala Leu Pro  Ala Pro Ile 
    1055                 1060                 1065             


Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln 
    1070                 1075                 1080             


Val Tyr  Thr Leu Pro Pro Ser  Arg Asp Glu Leu Thr  Lys Asn Gln 
    1085                 1090                 1095             


Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile 
    1100                 1105                 1110             


Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 
    1115                 1120                 1125             


Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 
    1130                 1135                 1140             


Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val 
    1145                 1150                 1155             


Phe Ser  Cys Ser Val Met His  Glu Ala Leu His Asn  His Tyr Thr 
    1160                 1165                 1170             


Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    1175                 1180             


<210>  60
<211>  1183
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_36_981F_C370S_GS_IgG1_noCH1_Fc_Fusion

<400>  60

Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn Val Tyr 
            500                 505                 510         


Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Val 
        515                 520                 525             


Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Gln 
    530                 535                 540                 


Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe Arg Phe 
545                 550                 555                 560 


Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val 
                565                 570                 575     


Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu Leu Val 
            580                 585                 590         


Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met Ala Pro 
        595                 600                 605             


Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp Glu Asn 
    610                 615                 620                 


Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Gln 
625                 630                 635                 640 


Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu Pro Tyr 
                645                 650                 655     


Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His 
            660                 665                 670         


Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala Gln Asn 
        675                 680                 685             


Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys 
    690                 695                 700                 


Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe 
705                 710                 715                 720 


Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro 
                725                 730                 735     


Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro 
            740                 745                 750         


Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe Asp Phe 
        755                 760                 765             


Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu Lys Glu 
    770                 775                 780                 


Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp 
785                 790                 795                 800 


Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly 
                805                 810                 815     


Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro 
            820                 825                 830         


Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala Glu Asp 
        835                 840                 845             


Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu Ala Leu 
    850                 855                 860                 


Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr 
865                 870                 875                 880 


Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg Tyr Ala 
                885                 890                 895     


Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg Lys Ile 
            900                 905                 910         


Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg Phe Cys 
        915                 920                 925             


Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His Thr Arg 
    930                 935                 940                 


Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His 
945                 950                 955                 960 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                965                 970                 975     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            980                 985                 990         


Pro Glu Val Thr Cys Val Val Val  Asp Val Ser His Glu  Asp Pro Glu 
        995                 1000                 1005             


Val Lys  Phe Asn Trp Tyr Val  Asp Gly Val Glu Val  His Asn Ala 
    1010                 1015                 1020             


Lys Thr  Lys Pro Arg Glu Glu  Gln Tyr Asn Ser Thr  Tyr Arg Val 
    1025                 1030                 1035             


Val Ser  Val Leu Thr Val Leu  His Gln Asp Trp Leu  Asn Gly Lys 
    1040                 1045                 1050             


Glu Tyr  Lys Cys Lys Val Ser  Asn Lys Ala Leu Pro  Ala Pro Ile 
    1055                 1060                 1065             


Glu Lys  Thr Ile Ser Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln 
    1070                 1075                 1080             


Val Tyr  Thr Leu Pro Pro Ser  Arg Asp Glu Leu Thr  Lys Asn Gln 
    1085                 1090                 1095             


Val Ser  Leu Thr Cys Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile 
    1100                 1105                 1110             


Ala Val  Glu Trp Glu Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys 
    1115                 1120                 1125             


Thr Thr  Pro Pro Val Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr 
    1130                 1135                 1140             


Ser Lys  Leu Thr Val Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val 
    1145                 1150                 1155             


Phe Ser  Cys Ser Val Met His  Glu Ala Leu His Asn  His Tyr Thr 
    1160                 1165                 1170             


Gln Lys  Ser Leu Ser Leu Ser  Pro Gly Lys 
    1175                 1180             


<210>  61
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_36_549F_GS_IgG1_noCH1_Fc_Fusion

<400>  61

Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr Lys Pro 
            500                 505                 510         


Tyr His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His 
        515                 520                 525             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    530                 535                 540                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
545                 550                 555                 560 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                565                 570                 575     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            580                 585                 590         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        595                 600                 605             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    610                 615                 620                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
625                 630                 635                 640 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                645                 650                 655     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            660                 665                 670         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        675                 680                 685             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    690                 695                 700                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
705                 710                 715                 720 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                725                 730                 735     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745                 750     


<210>  62
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_36_549F_C370S_GS_IgG1_noCH1_Fc_Fusion

<400>  62

Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro Ala Pro 
1               5                   10                  15      


Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp 
            20                  25                  30          


Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His 
        35                  40                  45              


Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala 
    50                  55                  60                  


Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser 
65                  70                  75                  80  


Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn 
                85                  90                  95      


Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr 
            100                 105                 110         


Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly 
        115                 120                 125             


Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg 
    130                 135                 140                 


Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp 
145                 150                 155                 160 


Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala 
                165                 170                 175     


Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe 
            180                 185                 190         


Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val 
        195                 200                 205             


Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly 
    210                 215                 220                 


Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His 
225                 230                 235                 240 


Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly 
                245                 250                 255     


Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg 
            260                 265                 270         


Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
        275                 280                 285             


Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu 
    290                 295                 300                 


Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser 
305                 310                 315                 320 


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser Phe 
                325                 330                 335     


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
            340                 345                 350         


Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
        355                 360                 365             


Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
    370                 375                 380                 


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
385                 390                 395                 400 


Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp 
                405                 410                 415     


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
            420                 425                 430         


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
        435                 440                 445             


Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
    450                 455                 460                 


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
465                 470                 475                 480 


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr 
                485                 490                 495     


Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr Lys Pro 
            500                 505                 510         


Tyr His Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His 
        515                 520                 525             


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
    530                 535                 540                 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
545                 550                 555                 560 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
                565                 570                 575     


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
            580                 585                 590         


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
        595                 600                 605             


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
    610                 615                 620                 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
625                 630                 635                 640 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
                645                 650                 655     


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
            660                 665                 670         


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
        675                 680                 685             


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
    690                 695                 700                 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
705                 710                 715                 720 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
                725                 730                 735     


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            740                 745                 750     


<210>  63
<211>  988
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_981V_TEV_TwinStrep

<400>  63

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Gly Gly Glu Asn Leu Tyr Phe Gln Ser Ser Ala Trp 
945                 950                 955                 960 


Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                965                 970                 975     


Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            980                 985             


<210>  64
<211>  956
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_981V_minus_TEV_TwinStrep

<400>  64

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Gly Gly Glu Asn Leu Tyr Phe Gln 
945                 950                 955     


<210>  65
<211>  988
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_981F_TEV_TwinStrep

<400>  65

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Gly Gly Glu Asn Leu Tyr Phe Gln Ser Ser Ala Trp 
945                 950                 955                 960 


Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                965                 970                 975     


Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            980                 985             


<210>  66
<211>  956
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_981F_minus_TEV_TwinStrep

<400>  66

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Gly Gly Glu Asn Leu Tyr Phe Gln 
945                 950                 955     


<210>  67
<211>  988
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_981V_C370S_TEV_TwinStrep

<400>  67

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Gly Gly Glu Asn Leu Tyr Phe Gln Ser Ser Ala Trp 
945                 950                 955                 960 


Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                965                 970                 975     


Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            980                 985             


<210>  68
<211>  956
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_981V_C370S_minus_TEV_TwinStrep

<400>  68

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Gly Gly Glu Asn Leu Tyr Phe Gln 
945                 950                 955     


<210>  69
<211>  988
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_981F_C370S_TEV_TwinStrep

<400>  69

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Gly Gly Glu Asn Leu Tyr Phe Gln Ser Ser Ala Trp 
945                 950                 955                 960 


Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly 
                965                 970                 975     


Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            980                 985             


<210>  70
<211>  956
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_34_981F_C370S_minus_TEV_TwinStrep

<400>  70

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu Asn 
            500                 505                 510         


Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp 
        515                 520                 525             


Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala 
    530                 535                 540                 


Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe 
545                 550                 555                 560 


Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser 
                565                 570                 575     


Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser Glu 
            580                 585                 590         


Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro Met 
        595                 600                 605             


Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala Trp 
    610                 615                 620                 


Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys 
625                 630                 635                 640 


Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn Glu 
                645                 650                 655     


Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys 
            660                 665                 670         


Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His Ala 
        675                 680                 685             


Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro 
    690                 695                 700                 


Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu 
705                 710                 715                 720 


Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp 
                725                 730                 735     


Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu 
            740                 745                 750         


Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr Phe 
        755                 760                 765             


Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser Glu 
    770                 775                 780                 


Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met 
785                 790                 795                 800 


Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro 
                805                 810                 815     


Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp 
            820                 825                 830         


Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His Ala 
        835                 840                 845             


Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn Glu 
    850                 855                 860                 


Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe 
865                 870                 875                 880 


Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr Arg 
                885                 890                 895     


Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr Arg 
            900                 905                 910         


Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu Arg 
        915                 920                 925             


Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe His 
    930                 935                 940                 


Thr Arg Lys Ser Gly Gly Glu Asn Leu Tyr Phe Gln 
945                 950                 955     


<210>  71
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala 
    


<210>  72
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_Synthetic_Signal_Peptide

<400>  72

Met Ala Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala 
            


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_GS_linker

<400>  73

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  74
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_ IgG1_noCH1_Fc_Fusion

<400>  74

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  75
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_TwinStrep

<400>  75

Gly Gly Glu Asn Leu Tyr Phe Gln Ser Ser Ala Trp Ser His Pro Gln 
1               5                   10                  15      


Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Ser Ala 
            20                  25                  30          


Trp Ser His Pro Gln Phe Glu Lys 
        35                  40  


<210>  76
<211>  3036
<212>  DNA
<213>  Homo sapiens

<400>  76
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc     1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc     1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc     1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct     1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc     1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac     2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc     2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat     2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct     2220

ttctcccaaa aggacaaaga ggtggccgag agagttttgg aatttgacat tggctggctg     2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa     2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc     2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat     2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac     2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag     2580

ttcaagtacg gagacctccc catgtacata atatccaacg gaatcgatga cgggctgcat     2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa     2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc     2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc     2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa     2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag     2940

tctttactgg ctttcatagc ttttctattt tttgcttcta ttatttctct ctcccttata     3000

ttttactact cgaagaaagg cagaagaagt tacaaa                               3036


<210>  77
<211>  2943
<212>  DNA
<213>  Homo sapiens

<400>  77
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc     1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc     1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc     1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct     1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc     1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac     2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc     2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat     2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct     2220

ttctcccaaa aggacaaaga ggtggccgag agagttttgg aatttgacat tggctggctg     2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa     2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc     2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat     2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac     2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag     2580

ttcaagtacg gagacctccc catgtacata atatccaacg gaatcgatga cgggctgcat     2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa     2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc     2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc     2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa     2880

agattttgtc cagaagaatt caccgtgtgt actgagtgca gtttttttca cacccgaaag     2940

tct                                                                   2943


<210>  78
<211>  2859
<212>  DNA
<213>  Homo sapiens

<400>  78
cgccgcctgc gtgcggagcc gggcgacggc gcgcagacct gggcccgtgt ctcgcggcct       60

cctgcccccg aggccgcggg cctcttccag ggcaccttcc ccgacggctt cctctgggcc      120

gtgggcagcg ccgcctacca gaccgagggc ggctggcagc agcacggcaa gggtgcgtcc      180

atctgggaca cgttcaccca ccaccccctg gcacccccgg gagactcccg gaacgccagt      240

ctgccgttgg gcgccccgtc gccgctgcag cccgccaccg gggacgtagc cagcgacagc      300

tacaacaacg tcttccgcga cacggaggcg ctgcgcgagc tcggggtcac tcactaccgc      360

ttctccatct cgtgggcgcg agtgctcccc aatggcagcg cgggcgtccc caaccgcgag      420

gggctgcgct actaccggcg cctgctggag cggctgcggg agctgggcgt gcagcccgtg      480

gtcaccctgt accactggga cctgccccag cgcctgcagg acgcctacgg cggctgggcc      540

aaccgcgccc tggccgacca cttcagggat tacgcggagc tctgcttccg ccacttcggc      600

ggtcaggtca agtactggat caccatcgac aacccctacg tggtggcctg gcacggctac      660

gccaccgggc gcctggcccc cggcatccgg ggcagcccgc ggctcgggta cctggtggcg      720

cacaacctcc tcctggctca tgccaaagtc tggcatctct acaatacttc tttccgtccc      780

actcagggag gtcaggtgtc cattgcccta agctctcact ggatcaatcc tcgaagaatg      840

accgaccaca gcatcaaaga atgtcaaaaa tctctggact ttgtactagg ttggtttgcc      900

aaacccgtat ttattgatgg tgactatccc gagagcatga agaataacct ttcatctatt      960

ctgcctgatt ttactgaatc tgagaaaaag ttcatcaaag gaactgctga cttttttgct     1020

ctttgctttg gacccacctt gagttttcaa cttttggacc ctcacatgaa gttccgccaa     1080

ttggaatctc ccaacctgag gcaactgctt tcctggattg accttgaatt taaccatcct     1140

caaatattta ttgtggaaaa tggctggttt gtctcaggga ccaccaagag agatgatgcc     1200

aaatatatgt attacctcaa aaagttcatc atggaaacct taaaagccat caagctggat     1260

ggggtggatg tcatcgggta taccgcatgg tccctcatgg atggtttcga gtggcacaga     1320

ggttacagca tcaggcgtgg actcttctat gttgactttc taagccagga caagatgttg     1380

ttgccaaagt cttcagcctt gttctaccaa aagctgatag agaaaaatgg cttccctcct     1440

ttacctgaaa atcagcccct agaagggaca tttccctgtg actttgcttg gggagttgtt     1500

gacaactaca ttcaagtaga taccactctg tctcagttta ccgacctgaa tgtttacctg     1560

tgggatgtcc accacagtaa aaggcttatt aaagtggatg gggttgtgac caagaagagg     1620

aaatcctact gtgttgactt tgctgccatc cagccccaga tcgctttact ccaggaaatg     1680

cacgttacac attttcgctt ctccctggac tgggccctga ttctccctct gggtaaccag     1740

tcccaggtga accacaccat cctgcagtac tatcgctgca tggccagcga gcttgtccgt     1800

gtcaacatca ccccagtggt ggccctgtgg cagcctatgg ccccgaacca aggactgccg     1860

cgcctcctgg ccaggcaggg cgcctgggag aacccctaca ctgccctggc ctttgcagag     1920

tatgcccgac tgtgctttca agagctcggc catcacgtca agctttggat aacgatgaat     1980

gagccgtata caaggaatat gacatacagt gctggccaca accttctgaa ggcccatgcc     2040

ctggcttggc atgtgtacaa tgaaaagttt aggcatgctc agaatgggaa aatatccata     2100

gccttgcagg ctgattggat agaacctgcc tgccctttct cccaaaagga caaagaggtg     2160

gccgagagag ttttggaatt tgacattggc tggctggctg agcccatttt cggctctgga     2220

gattatccat gggtgatgag ggactggctg aaccaaagaa acaattttct tcttccttat     2280

ttcactgaag atgaaaaaaa gctaatccag ggtacctttg actttttggc tttaagccat     2340

tataccacca tccttgtaga ctcagaaaaa gaagatccaa taaaatacaa tgattaccta     2400

gaagtgcaag aaatgaccga catcacgtgg ctcaactccc ccagtcaggt ggcggtagtg     2460

ccctgggggt tgcgcaaagt gctgaactgg ctgaagttca agtacggaga cctccccatg     2520

tacataatat ccaacggaat cgatgacggg ctgcatgctg aggacgacca gctgagggtg     2580

tattatatgc agaattacat aaacgaagct ctcaaagccc acatactgga tggtatcaat     2640

ctttgcggat actttgctta ttcgtttaac gaccgcacag ctccgaggtt tggcctctat     2700

cgttatgctg cagatcagtt tgagcccaag gcatccatga aacattacag gaaaattatt     2760

gacagcaatg gtttcccggg cccagaaact ctggaaagat tttgtccaga agaattcacc     2820

gtgtgtactg agtgcagttt ttttcacacc cgaaagtct                            2859


<210>  79
<211>  2844
<212>  DNA
<213>  Homo sapiens

<400>  79
gagccgggcg acggcgcgca gacctgggcc cgtgtctcgc ggcctcctgc ccccgaggcc       60

gcgggcctct tccagggcac cttccccgac ggcttcctct gggccgtggg cagcgccgcc      120

taccagaccg agggcggctg gcagcagcac ggcaagggtg cgtccatctg ggacacgttc      180

acccaccacc ccctggcacc cccgggagac tcccggaacg ccagtctgcc gttgggcgcc      240

ccgtcgccgc tgcagcccgc caccggggac gtagccagcg acagctacaa caacgtcttc      300

cgcgacacgg aggcgctgcg cgagctcggg gtcactcact accgcttctc catctcgtgg      360

gcgcgagtgc tccccaatgg cagcgcgggc gtccccaacc gcgaggggct gcgctactac      420

cggcgcctgc tggagcggct gcgggagctg ggcgtgcagc ccgtggtcac cctgtaccac      480

tgggacctgc cccagcgcct gcaggacgcc tacggcggct gggccaaccg cgccctggcc      540

gaccacttca gggattacgc ggagctctgc ttccgccact tcggcggtca ggtcaagtac      600

tggatcacca tcgacaaccc ctacgtggtg gcctggcacg gctacgccac cgggcgcctg      660

gcccccggca tccggggcag cccgcggctc gggtacctgg tggcgcacaa cctcctcctg      720

gctcatgcca aagtctggca tctctacaat acttctttcc gtcccactca gggaggtcag      780

gtgtccattg ccctaagctc tcactggatc aatcctcgaa gaatgaccga ccacagcatc      840

aaagaatgtc aaaaatctct ggactttgta ctaggttggt ttgccaaacc cgtatttatt      900

gatggtgact atcccgagag catgaagaat aacctttcat ctattctgcc tgattttact      960

gaatctgaga aaaagttcat caaaggaact gctgactttt ttgctctttg ctttggaccc     1020

accttgagtt ttcaactttt ggaccctcac atgaagttcc gccaattgga atctcccaac     1080

ctgaggcaac tgctttcctg gattgacctt gaatttaacc atcctcaaat atttattgtg     1140

gaaaatggct ggtttgtctc agggaccacc aagagagatg atgccaaata tatgtattac     1200

ctcaaaaagt tcatcatgga aaccttaaaa gccatcaagc tggatggggt ggatgtcatc     1260

gggtataccg catggtccct catggatggt ttcgagtggc acagaggtta cagcatcagg     1320

cgtggactct tctatgttga ctttctaagc caggacaaga tgttgttgcc aaagtcttca     1380

gccttgttct accaaaagct gatagagaaa aatggcttcc ctcctttacc tgaaaatcag     1440

cccctagaag ggacatttcc ctgtgacttt gcttggggag ttgttgacaa ctacattcaa     1500

gtagatacca ctctgtctca gtttaccgac ctgaatgttt acctgtggga tgtccaccac     1560

agtaaaaggc ttattaaagt ggatggggtt gtgaccaaga agaggaaatc ctactgtgtt     1620

gactttgctg ccatccagcc ccagatcgct ttactccagg aaatgcacgt tacacatttt     1680

cgcttctccc tggactgggc cctgattctc cctctgggta accagtccca ggtgaaccac     1740

accatcctgc agtactatcg ctgcatggcc agcgagcttg tccgtgtcaa catcacccca     1800

gtggtggccc tgtggcagcc tatggccccg aaccaaggac tgccgcgcct cctggccagg     1860

cagggcgcct gggagaaccc ctacactgcc ctggcctttg cagagtatgc ccgactgtgc     1920

tttcaagagc tcggccatca cgtcaagctt tggataacga tgaatgagcc gtatacaagg     1980

aatatgacat acagtgctgg ccacaacctt ctgaaggccc atgccctggc ttggcatgtg     2040

tacaatgaaa agtttaggca tgctcagaat gggaaaatat ccatagcctt gcaggctgat     2100

tggatagaac ctgcctgccc tttctcccaa aaggacaaag aggtggccga gagagttttg     2160

gaatttgaca ttggctggct ggctgagccc attttcggct ctggagatta tccatgggtg     2220

atgagggact ggctgaacca aagaaacaat tttcttcttc cttatttcac tgaagatgaa     2280

aaaaagctaa tccagggtac ctttgacttt ttggctttaa gccattatac caccatcctt     2340

gtagactcag aaaaagaaga tccaataaaa tacaatgatt acctagaagt gcaagaaatg     2400

accgacatca cgtggctcaa ctcccccagt caggtggcgg tagtgccctg ggggttgcgc     2460

aaagtgctga actggctgaa gttcaagtac ggagacctcc ccatgtacat aatatccaac     2520

ggaatcgatg acgggctgca tgctgaggac gaccagctga gggtgtatta tatgcagaat     2580

tacataaacg aagctctcaa agcccacata ctggatggta tcaatctttg cggatacttt     2640

gcttattcgt ttaacgaccg cacagctccg aggtttggcc tctatcgtta tgctgcagat     2700

cagtttgagc ccaaggcatc catgaaacat tacaggaaaa ttattgacag caatggtttc     2760

ccgggcccag aaactctgga aagattttgt ccagaagaat tcaccgtgtg tactgagtgc     2820

agtttttttc acacccgaaa gtct                                            2844


<210>  80
<211>  2838
<212>  DNA
<213>  Homo sapiens

<400>  80
ggcgacggcg cgcagacctg ggcccgtgtc tcgcggcctc ctgcccccga ggccgcgggc       60

ctcttccagg gcaccttccc cgacggcttc ctctgggccg tgggcagcgc cgcctaccag      120

accgagggcg gctggcagca gcacggcaag ggtgcgtcca tctgggacac gttcacccac      180

caccccctgg cacccccggg agactcccgg aacgccagtc tgccgttggg cgccccgtcg      240

ccgctgcagc ccgccaccgg ggacgtagcc agcgacagct acaacaacgt cttccgcgac      300

acggaggcgc tgcgcgagct cggggtcact cactaccgct tctccatctc gtgggcgcga      360

gtgctcccca atggcagcgc gggcgtcccc aaccgcgagg ggctgcgcta ctaccggcgc      420

ctgctggagc ggctgcggga gctgggcgtg cagcccgtgg tcaccctgta ccactgggac      480

ctgccccagc gcctgcagga cgcctacggc ggctgggcca accgcgccct ggccgaccac      540

ttcagggatt acgcggagct ctgcttccgc cacttcggcg gtcaggtcaa gtactggatc      600

accatcgaca acccctacgt ggtggcctgg cacggctacg ccaccgggcg cctggccccc      660

ggcatccggg gcagcccgcg gctcgggtac ctggtggcgc acaacctcct cctggctcat      720

gccaaagtct ggcatctcta caatacttct ttccgtccca ctcagggagg tcaggtgtcc      780

attgccctaa gctctcactg gatcaatcct cgaagaatga ccgaccacag catcaaagaa      840

tgtcaaaaat ctctggactt tgtactaggt tggtttgcca aacccgtatt tattgatggt      900

gactatcccg agagcatgaa gaataacctt tcatctattc tgcctgattt tactgaatct      960

gagaaaaagt tcatcaaagg aactgctgac ttttttgctc tttgctttgg acccaccttg     1020

agttttcaac ttttggaccc tcacatgaag ttccgccaat tggaatctcc caacctgagg     1080

caactgcttt cctggattga ccttgaattt aaccatcctc aaatatttat tgtggaaaat     1140

ggctggtttg tctcagggac caccaagaga gatgatgcca aatatatgta ttacctcaaa     1200

aagttcatca tggaaacctt aaaagccatc aagctggatg gggtggatgt catcgggtat     1260

accgcatggt ccctcatgga tggtttcgag tggcacagag gttacagcat caggcgtgga     1320

ctcttctatg ttgactttct aagccaggac aagatgttgt tgccaaagtc ttcagccttg     1380

ttctaccaaa agctgataga gaaaaatggc ttccctcctt tacctgaaaa tcagccccta     1440

gaagggacat ttccctgtga ctttgcttgg ggagttgttg acaactacat tcaagtagat     1500

accactctgt ctcagtttac cgacctgaat gtttacctgt gggatgtcca ccacagtaaa     1560

aggcttatta aagtggatgg ggttgtgacc aagaagagga aatcctactg tgttgacttt     1620

gctgccatcc agccccagat cgctttactc caggaaatgc acgttacaca ttttcgcttc     1680

tccctggact gggccctgat tctccctctg ggtaaccagt cccaggtgaa ccacaccatc     1740

ctgcagtact atcgctgcat ggccagcgag cttgtccgtg tcaacatcac cccagtggtg     1800

gccctgtggc agcctatggc cccgaaccaa ggactgccgc gcctcctggc caggcagggc     1860

gcctgggaga acccctacac tgccctggcc tttgcagagt atgcccgact gtgctttcaa     1920

gagctcggcc atcacgtcaa gctttggata acgatgaatg agccgtatac aaggaatatg     1980

acatacagtg ctggccacaa ccttctgaag gcccatgccc tggcttggca tgtgtacaat     2040

gaaaagttta ggcatgctca gaatgggaaa atatccatag ccttgcaggc tgattggata     2100

gaacctgcct gccctttctc ccaaaaggac aaagaggtgg ccgagagagt tttggaattt     2160

gacattggct ggctggctga gcccattttc ggctctggag attatccatg ggtgatgagg     2220

gactggctga accaaagaaa caattttctt cttccttatt tcactgaaga tgaaaaaaag     2280

ctaatccagg gtacctttga ctttttggct ttaagccatt ataccaccat ccttgtagac     2340

tcagaaaaag aagatccaat aaaatacaat gattacctag aagtgcaaga aatgaccgac     2400

atcacgtggc tcaactcccc cagtcaggtg gcggtagtgc cctgggggtt gcgcaaagtg     2460

ctgaactggc tgaagttcaa gtacggagac ctccccatgt acataatatc caacggaatc     2520

gatgacgggc tgcatgctga ggacgaccag ctgagggtgt attatatgca gaattacata     2580

aacgaagctc tcaaagccca catactggat ggtatcaatc tttgcggata ctttgcttat     2640

tcgtttaacg accgcacagc tccgaggttt ggcctctatc gttatgctgc agatcagttt     2700

gagcccaagg catccatgaa acattacagg aaaattattg acagcaatgg tttcccgggc     2760

ccagaaactc tggaaagatt ttgtccagaa gaattcaccg tgtgtactga gtgcagtttt     2820

tttcacaccc gaaagtct                                                   2838


<210>  81
<211>  2553
<212>  DNA
<213>  Homo sapiens

<400>  81
aacgtcttcc gcgacacgga ggcgctgcgc gagctcgggg tcactcacta ccgcttctcc       60

atctcgtggg cgcgagtgct ccccaatggc agcgcgggcg tccccaaccg cgaggggctg      120

cgctactacc ggcgcctgct ggagcggctg cgggagctgg gcgtgcagcc cgtggtcacc      180

ctgtaccact gggacctgcc ccagcgcctg caggacgcct acggcggctg ggccaaccgc      240

gccctggccg accacttcag ggattacgcg gagctctgct tccgccactt cggcggtcag      300

gtcaagtact ggatcaccat cgacaacccc tacgtggtgg cctggcacgg ctacgccacc      360

gggcgcctgg cccccggcat ccggggcagc ccgcggctcg ggtacctggt ggcgcacaac      420

ctcctcctgg ctcatgccaa agtctggcat ctctacaata cttctttccg tcccactcag      480

ggaggtcagg tgtccattgc cctaagctct cactggatca atcctcgaag aatgaccgac      540

cacagcatca aagaatgtca aaaatctctg gactttgtac taggttggtt tgccaaaccc      600

gtatttattg atggtgacta tcccgagagc atgaagaata acctttcatc tattctgcct      660

gattttactg aatctgagaa aaagttcatc aaaggaactg ctgacttttt tgctctttgc      720

tttggaccca ccttgagttt tcaacttttg gaccctcaca tgaagttccg ccaattggaa      780

tctcccaacc tgaggcaact gctttcctgg attgaccttg aatttaacca tcctcaaata      840

tttattgtgg aaaatggctg gtttgtctca gggaccacca agagagatga tgccaaatat      900

atgtattacc tcaaaaagtt catcatggaa accttaaaag ccatcaagct ggatggggtg      960

gatgtcatcg ggtataccgc atggtccctc atggatggtt tcgagtggca cagaggttac     1020

agcatcaggc gtggactctt ctatgttgac tttctaagcc aggacaagat gttgttgcca     1080

aagtcttcag ccttgttcta ccaaaagctg atagagaaaa atggcttccc tcctttacct     1140

gaaaatcagc ccctagaagg gacatttccc tgtgactttg cttggggagt tgttgacaac     1200

tacattcaag tagataccac tctgtctcag tttaccgacc tgaatgttta cctgtgggat     1260

gtccaccaca gtaaaaggct tattaaagtg gatggggttg tgaccaagaa gaggaaatcc     1320

tactgtgttg actttgctgc catccagccc cagatcgctt tactccagga aatgcacgtt     1380

acacattttc gcttctccct ggactgggcc ctgattctcc ctctgggtaa ccagtcccag     1440

gtgaaccaca ccatcctgca gtactatcgc tgcatggcca gcgagcttgt ccgtgtcaac     1500

atcaccccag tggtggccct gtggcagcct atggccccga accaaggact gccgcgcctc     1560

ctggccaggc agggcgcctg ggagaacccc tacactgccc tggcctttgc agagtatgcc     1620

cgactgtgct ttcaagagct cggccatcac gtcaagcttt ggataacgat gaatgagccg     1680

tatacaagga atatgacata cagtgctggc cacaaccttc tgaaggccca tgccctggct     1740

tggcatgtgt acaatgaaaa gtttaggcat gctcagaatg ggaaaatatc catagccttg     1800

caggctgatt ggatagaacc tgcctgccct ttctcccaaa aggacaaaga ggtggccgag     1860

agagttttgg aatttgacat tggctggctg gctgagccca ttttcggctc tggagattat     1920

ccatgggtga tgagggactg gctgaaccaa agaaacaatt ttcttcttcc ttatttcact     1980

gaagatgaaa aaaagctaat ccagggtacc tttgactttt tggctttaag ccattatacc     2040

accatccttg tagactcaga aaaagaagat ccaataaaat acaatgatta cctagaagtg     2100

caagaaatga ccgacatcac gtggctcaac tcccccagtc aggtggcggt agtgccctgg     2160

gggttgcgca aagtgctgaa ctggctgaag ttcaagtacg gagacctccc catgtacata     2220

atatccaacg gaatcgatga cgggctgcat gctgaggacg accagctgag ggtgtattat     2280

atgcagaatt acataaacga agctctcaaa gcccacatac tggatggtat caatctttgc     2340

ggatactttg cttattcgtt taacgaccgc acagctccga ggtttggcct ctatcgttat     2400

gctgcagatc agtttgagcc caaggcatcc atgaaacatt acaggaaaat tattgacagc     2460

aatggtttcc cgggcccaga aactctggaa agattttgtc cagaagaatt caccgtgtgt     2520

actgagtgca gtttttttca cacccgaaag tct                                  2553


<210>  82
<211>  1648
<212>  DNA
<213>  Homo sapiens

<400>  82
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtgtctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gacacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtggg                                        1648


<210>  83
<211>  1564
<212>  DNA
<213>  Homo sapiens

<400>  83
cgccgcctgc gtgcggagcc gggcgacggc gcgcagacct gggcccgtgt ctcgcggcct       60

cctgcccccg aggccgcggg cctcttccag ggcaccttcc ccgacggctt cctctgggcc      120

gtgggcagcg ccgcctacca gaccgagggc ggctggcagc agcacggcaa gggtgcgtcc      180

atctgggaca cgttcaccca ccaccccctg gcacccccgg gagactcccg gaacgccagt      240

ctgccgttgg gcgccccgtc gccgctgcag cccgccaccg gggacgtagc cagcgacagc      300

tacaacaacg tcttccgcga cacggaggcg ctgcgcgagc tcggggtcac tcactaccgc      360

ttctccatct cgtgggcgcg agtgctcccc aatggcagcg cgggcgtccc caaccgcgag      420

gggctgcgct actaccggcg cctgctggag cggctgcggg agctgggcgt gcagcccgtg      480

gtcaccctgt accactggga cctgccccag cgcctgcagg acgcctacgg cggctgggcc      540

aaccgcgccc tggccgacca cttcagggat tacgcggagc tctgcttccg ccacttcggc      600

ggtcaggtca agtactggat caccatcgac aacccctacg tggtggcctg gcacggctac      660

gccaccgggc gcctggcccc cggcatccgg ggcagcccgc ggctcgggta cctggtggcg      720

cacaacctcc tcctggctca tgccaaagtc tggcatctct acaatacttc tttccgtccc      780

actcagggag gtcaggtgtc cattgcccta agctctcact ggatcaatcc tcgaagaatg      840

accgaccaca gcatcaaaga atgtcaaaaa tctctggact ttgtactagg ttggtttgcc      900

aaacccgtat ttattgatgg tgactatccc gagagcatga agaataacct ttcatctatt      960

ctgcctgatt ttactgaatc tgagaaaaag ttcatcaaag gaactgctga cttttttgct     1020

ctttgctttg gacccacctt gagttttcaa cttttggacc ctcacatgaa gttccgccaa     1080

ttggaatctc ccaacctgag gcaactgctt tcctggattg accttgaatt taaccatcct     1140

caaatattta ttgtggaaaa tggctggttt gtctcaggga ccaccaagag agatgatgcc     1200

aaatatatgt attacctcaa aaagttcatc atggaaacct taaaagccat caagctggat     1260

ggggtggatg tcatcgggta taccgcatgg tccctcatgg atggtttcga gtggcacaga     1320

ggttacagca tcaggcgtgg actcttctat gttgactttc taagccagga caagatgttg     1380

ttgccaaagt cttcagcctt gttctaccaa aagctgatag agaaaaatgg cttccctcct     1440

ttacctgaaa atcagcccct agaagggaca tttccctgtg actttgcttg gggagttgtt     1500

gacaactaca ttcaagtaga taccactctg tctcagttta ccgacctgaa tgtttacctg     1560

tggg                                                                  1564


<210>  84
<211>  1549
<212>  DNA
<213>  Homo sapiens

<400>  84
gagccgggcg acggcgcgca gacctgggcc cgtgtctcgc ggcctcctgc ccccgaggcc       60

gcgggcctct tccagggcac cttccccgac ggcttcctct gggccgtggg cagcgccgcc      120

taccagaccg agggcggctg gcagcagcac ggcaagggtg cgtccatctg ggacacgttc      180

acccaccacc ccctggcacc cccgggagac tcccggaacg ccagtctgcc gttgggcgcc      240

ccgtcgccgc tgcagcccgc caccggggac gtagccagcg acagctacaa caacgtcttc      300

cgcgacacgg aggcgctgcg cgagctcggg gtcactcact accgcttctc catctcgtgg      360

gcgcgagtgc tccccaatgg cagcgcgggc gtccccaacc gcgaggggct gcgctactac      420

cggcgcctgc tggagcggct gcgggagctg ggcgtgcagc ccgtggtcac cctgtaccac      480

tgggacctgc cccagcgcct gcaggacgcc tacggcggct gggccaaccg cgccctggcc      540

gaccacttca gggattacgc ggagctctgc ttccgccact tcggcggtca ggtcaagtac      600

tggatcacca tcgacaaccc ctacgtggtg gcctggcacg gctacgccac cgggcgcctg      660

gcccccggca tccggggcag cccgcggctc gggtacctgg tggcgcacaa cctcctcctg      720

gctcatgcca aagtctggca tctctacaat acttctttcc gtcccactca gggaggtcag      780

gtgtccattg ccctaagctc tcactggatc aatcctcgaa gaatgaccga ccacagcatc      840

aaagaatgtc aaaaatctct ggactttgta ctaggttggt ttgccaaacc cgtatttatt      900

gatggtgact atcccgagag catgaagaat aacctttcat ctattctgcc tgattttact      960

gaatctgaga aaaagttcat caaaggaact gctgactttt ttgctctttg ctttggaccc     1020

accttgagtt ttcaactttt ggaccctcac atgaagttcc gccaattgga atctcccaac     1080

ctgaggcaac tgctttcctg gattgacctt gaatttaacc atcctcaaat atttattgtg     1140

gaaaatggct ggtttgtctc agggaccacc aagagagatg atgccaaata tatgtattac     1200

ctcaaaaagt tcatcatgga aaccttaaaa gccatcaagc tggatggggt ggatgtcatc     1260

gggtataccg catggtccct catggatggt ttcgagtggc acagaggtta cagcatcagg     1320

cgtggactct tctatgttga ctttctaagc caggacaaga tgttgttgcc aaagtcttca     1380

gccttgttct accaaaagct gatagagaaa aatggcttcc ctcctttacc tgaaaatcag     1440

cccctagaag ggacatttcc ctgtgacttt gcttggggag ttgttgacaa ctacattcaa     1500

gtagatacca ctctgtctca gtttaccgac ctgaatgttt acctgtggg                 1549


<210>  85
<211>  1543
<212>  DNA
<213>  Homo sapiens

<400>  85
ggcgacggcg cgcagacctg ggcccgtgtc tcgcggcctc ctgcccccga ggccgcgggc       60

ctcttccagg gcaccttccc cgacggcttc ctctgggccg tgggcagcgc cgcctaccag      120

accgagggcg gctggcagca gcacggcaag ggtgcgtcca tctgggacac gttcacccac      180

caccccctgg cacccccggg agactcccgg aacgccagtc tgccgttggg cgccccgtcg      240

ccgctgcagc ccgccaccgg ggacgtagcc agcgacagct acaacaacgt cttccgcgac      300

acggaggcgc tgcgcgagct cggggtcact cactaccgct tctccatctc gtgggcgcga      360

gtgctcccca atggcagcgc gggcgtcccc aaccgcgagg ggctgcgcta ctaccggcgc      420

ctgctggagc ggctgcggga gctgggcgtg cagcccgtgg tcaccctgta ccactgggac      480

ctgccccagc gcctgcagga cgcctacggc ggctgggcca accgcgccct ggccgaccac      540

ttcagggatt acgcggagct ctgcttccgc cacttcggcg gtcaggtcaa gtactggatc      600

accatcgaca acccctacgt ggtggcctgg cacggctacg ccaccgggcg cctggccccc      660

ggcatccggg gcagcccgcg gctcgggtac ctggtggcgc acaacctcct cctggctcat      720

gccaaagtct ggcatctcta caatacttct ttccgtccca ctcagggagg tcaggtgtcc      780

attgccctaa gctctcactg gatcaatcct cgaagaatga ccgaccacag catcaaagaa      840

tgtcaaaaat ctctggactt tgtactaggt tggtttgcca aacccgtatt tattgatggt      900

gactatcccg agagcatgaa gaataacctt tcatctattc tgcctgattt tactgaatct      960

gagaaaaagt tcatcaaagg aactgctgac ttttttgctc tttgctttgg acccaccttg     1020

agttttcaac ttttggaccc tcacatgaag ttccgccaat tggaatctcc caacctgagg     1080

caactgcttt cctggattga ccttgaattt aaccatcctc aaatatttat tgtggaaaat     1140

ggctggtttg tctcagggac caccaagaga gatgatgcca aatatatgta ttacctcaaa     1200

aagttcatca tggaaacctt aaaagccatc aagctggatg gggtggatgt catcgggtat     1260

accgcatggt ccctcatgga tggtttcgag tggcacagag gttacagcat caggcgtgga     1320

ctcttctatg ttgactttct aagccaggac aagatgttgt tgccaaagtc ttcagccttg     1380

ttctaccaaa agctgataga gaaaaatggc ttccctcctt tacctgaaaa tcagccccta     1440

gaagggacat ttccctgtga ctttgcttgg ggagttgttg acaactacat tcaagtagat     1500

accactctgt ctcagtttac cgacctgaat gtttacctgt ggg                       1543


<210>  86
<211>  1258
<212>  DNA
<213>  Homo sapiens

<400>  86
aacgtcttcc gcgacacgga ggcgctgcgc gagctcgggg tcactcacta ccgcttctcc       60

atctcgtggg cgcgagtgct ccccaatggc agcgcgggcg tccccaaccg cgaggggctg      120

cgctactacc ggcgcctgct ggagcggctg cgggagctgg gcgtgcagcc cgtggtcacc      180

ctgtaccact gggacctgcc ccagcgcctg caggacgcct acggcggctg ggccaaccgc      240

gccctggccg accacttcag ggattacgcg gagctctgct tccgccactt cggcggtcag      300

gtcaagtact ggatcaccat cgacaacccc tacgtggtgg cctggcacgg ctacgccacc      360

gggcgcctgg cccccggcat ccggggcagc ccgcggctcg ggtacctggt ggcgcacaac      420

ctcctcctgg ctcatgccaa agtctggcat ctctacaata cttctttccg tcccactcag      480

ggaggtcagg tgtccattgc cctaagctct cactggatca atcctcgaag aatgaccgac      540

cacagcatca aagaatgtca aaaatctctg gactttgtac taggttggtt tgccaaaccc      600

gtatttattg atggtgacta tcccgagagc atgaagaata acctttcatc tattctgcct      660

gattttactg aatctgagaa aaagttcatc aaaggaactg ctgacttttt tgctctttgc      720

tttggaccca ccttgagttt tcaacttttg gaccctcaca tgaagttccg ccaattggaa      780

tctcccaacc tgaggcaact gctttcctgg attgaccttg aatttaacca tcctcaaata      840

tttattgtgg aaaatggctg gtttgtctca gggaccacca agagagatga tgccaaatat      900

atgtattacc tcaaaaagtt catcatggaa accttaaaag ccatcaagct ggatggggtg      960

gatgtcatcg ggtataccgc atggtccctc atggatggtt tcgagtggca cagaggttac     1020

agcatcaggc gtggactctt ctatgttgac tttctaagcc aggacaagat gttgttgcca     1080

aagtcttcag ccttgttcta ccaaaagctg atagagaaaa atggcttccc tcctttacct     1140

gaaaatcagc ccctagaagg gacatttccc tgtgactttg cttggggagt tgttgacaac     1200

tacattcaag tagataccac tctgtctcag tttaccgacc tgaatgttta cctgtggg       1258


<210>  87
<211>  3654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA_Native_SS_34_981_GS_IgG1_noCH1_Fc_Fusion

<400>  87
atgcctgctt ccgccccgcc tagaaggcct cggcctcctc cccccagcct gtctctgctc       60

ttggtgctgc tgggactggg tggacggcgc cttcgcgcag agcctggcga cggcgcccag      120

acctgggccc gggtgtcgag gccgccagcg cccgaggccg ccggactgtt ccagggaacc      180

ttccctgatg ggttcctctg ggccgtgggc tcagccgcat accagaccga ggggggctgg      240

cagcagcacg gaaagggcgc cagcatatgg gacacgttca cccaccaccc gctggctccg      300

cccggggact ccagaaacgc ctccttgccc ctcggtgctc cttcgccact gcaacccgca      360

accggcgacg tggccagcga ttcatacaac aacgtgttcc gggacaccga ggccctgagg      420

gaactgggag tgactcacta ccgcttttcg atctcctggg cacgcgtgct cccgaacgga      480

tcggcgggag tgccgaatcg cgagggcctg cggtactacc gacggctgct ggaaaggctc      540

agagaactgg gcgtgcagcc tgtcgtgact ctttaccact gggatctgcc ccaacggctg      600

caggatgctt acgggggatg ggccaataga gccctggctg atcacttccg cgactacgcc      660

gaattgtgct tccggcactt cggtggccaa gtcaagtact ggattaccat cgacaaccca      720

tacgtcgtgg cgtggcacgg atacgcaacc ggtcggctgg cccctggtat tcgcgggtcc      780

ccgcggcttg gatacctggt ggcccacaac ctgttgctcg cgcatgccaa agtctggcac      840

ctgtacaaca cctcgttccg gccgacccag ggtggacaag tgtccatcgc cctgtcgtca      900

cactggatca acccgcggag aatgaccgac cactccatca aggaatgcca gaagtccctc      960

gatttcgtgt tgggctggtt tgccaagcct gtgtttattg acggagacta ccccgagtcc     1020

atgaagaaca acctgtcgtc tatcctgccc gatttcactg aatccgagaa aaagtttatc     1080

aagggaaccg ctgacttctt cgccctctgt ttcggcccga ccttgtcctt ccaactgctc     1140

gatcctcata tgaagttccg gcagctggaa tcccctaacc ttcgccagct gctgtcctgg     1200

atcgacttgg aattcaacca cccgcagatc ttcattgtcg agaacggctg gttcgtgtcc     1260

gggaccacca agcgcgacga cgccaagtac atgtattatc tcaaaaagtt catcatggaa     1320

accctcaagg ccatcaaatt ggatggcgtg gacgtgatcg gatatacggc gtggagcctg     1380

atggacggtt tcgagtggca ccgcggatac agcatccgca gaggactctt ctacgtggac     1440

ttcctgtcgc aagacaagat gctgctgcct aagagcagcg cgctgttcta ccaaaagctc     1500

attgagaaga acgggttccc gcccctgccg gagaaccagc ctctggaagg gaccttccct     1560

tgcgacttcg cctggggagt ggtggacaac tacatccagg tcgataccac tctgagccag     1620

ttcaccgacc tgaacgtgta cctgtgggac gtgcatcaca gcaagaggct cattaaggtc     1680

gacggagtgg tcaccaagaa gagaaagtcg tactgcgtgg atttcgccgc aatccagcca     1740

cagatcgccc tgctgcaaga gatgcacgtg acccatttcc gcttctccct ggattgggcc     1800

ctgattctcc cgctggggaa ccagtcgcaa gtgaaccaca ctatcctgca atactaccgg     1860

tgcatggctt ccgagctcgt ccgcgtgaat atcacccccg tggtggcgct ctggcagcct     1920

atggccccga accagggact gccacgactg ctggccagac agggagcgtg ggaaaacccg     1980

tacacagcac tggcctttgc ggagtacgcc cggctgtgct tccaggaact tgggcatcac     2040

gtcaagcttt ggattactat gaacgaaccc tacactagga acatgactta ctcagccgga     2100

cataaccttc tgaaggcaca cgccctcgct tggcacgtgt acaacgaaaa gttcagacac     2160

gctcagaacg gaaagatttc catcgcgctg caagcagact ggatcgagcc cgcctgccct     2220

ttctcccaaa aagacaagga agtggccgaa cgggtgctgg aattcgacat cggatggctg     2280

gccgaaccca tcttcggctc cggcgattat ccatgggtca tgcgggactg gctcaaccag     2340

cgcaacaact ttttgctgcc atacttcacc gaagatgaga agaagctgat ccagggcacc     2400

tttgatttcc tggcgctgag ccactacact acgattctgg tggacagcga aaaggaggac     2460

ccgattaagt acaacgacta cctggaagtc caggaaatga ccgatattac ttggctgaac     2520

tcacctagcc aagtggcggt ggtgccttgg ggactgagaa aggtcctcaa ctggctcaaa     2580

ttcaaatacg gagatctgcc catgtacatc atctccaatg ggatcgacga cggcctgcat     2640

gctgaggacg atcagctccg cgtgtactat atgcagaact acattaacga ggcactgaag     2700

gcccatattc tggacggcat taacctctgc ggttattttg cctactcgtt caacgaccgg     2760

actgcccccc gcttcgggtt gtaccgctac gccgcggatc agtttgagcc aaaggcctcc     2820

atgaagcatt accgcaagat cattgattcc aatggatttc cgggccccga aaccctcgaa     2880

cggttctgtc cggaagagtt caccgtgtgt accgagtgct ccttctttca cacccgcaag     2940

agcgggggtg gcggaagcgg tggcggagga agcgacaaaa ctcacacatg cccaccgtgc     3000

ccagcacctg aactcctggg gggaccgtca gtcttcctct tccccccaaa acccaaggac     3060

accctcatga tctcccggac ccctgaggtc acatgcgtgg tggtggacgt gagccacgaa     3120

gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca     3180

aagccgcggg aggagcagta caacagcacg taccgggtgg tcagcgtcct caccgtcctg     3240

caccaggact ggctgaatgg caaggagtac aagtgcaagg tcagcaacaa agccctccca     3300

gcccccatcg agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac     3360

accctgcccc catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc     3420

aaaggcttct atcccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac     3480

aactacaaga ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag     3540

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat     3600

gaggctctgc acaaccacta cacgcagaag tccctctccc tgtctccggg taaa           3654


<210>  88
<211>  2358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA_Native_Secreted_Iso2_SS_34_549_GS_IgG1_noCH1_Fc_Fusion

<400>  88
atgccagctt ccgccccccc tcggcggcct agacccccac ctccctccct gtcgctgctg       60

ctggtgctgc tcggtctggg cggacggaga ctcagggccg agcctggcga cggcgcacag      120

acctgggccc ggttctcacg ccccccggcc ccggaagccg ccggactgtt tcagggaacc      180

ttccccgacg gattcctgtg ggccgtgggt agcgcggcgt accagactga gggcggatgg      240

cagcagcacg gaaagggagc ctcaatttgg gatactttca ctcatcatcc cctcgccccg      300

ccgggggatt cgcggaacgc ctccctcccc ctgggtgctc ctagcccgct gcagccagcc      360

accggcgacg tggcatccga cagctacaac aacgtgttcc gggacaccga ggccctgagg      420

gaactgggag tgactcacta ccgcttttcg atctcctggg cacgcgtgct cccgaacgga      480

tcggcgggag tgccgaatcg cgagggcctg cggtactacc gacggctgct ggaaaggctc      540

agagaactgg gcgtgcagcc tgtcgtgact ctttaccact gggatctgcc ccaacggctg      600

caggatgctt acgggggatg ggccaataga gccctggctg atcacttccg cgactacgcc      660

gaattgtgct tccggcactt cggtggccaa gtcaagtact ggattaccat cgacaaccca      720

tacgtcgtgg cgtggcacgg atacgcaacc ggtcggctgg cccctggtat tcgcgggtcc      780

ccgcggcttg gatacctggt ggcccacaac ctgttgctcg cgcatgccaa agtctggcac      840

ctgtacaaca cctcgttccg gccgacccag ggtggacaag tgtccatcgc cctgtcgtca      900

cactggatca acccgcggag aatgaccgac cactccatca aggaatgcca gaagtccctc      960

gatttcgtgt tgggctggtt tgccaagcct gtgtttattg acggagacta ccccgagtcc     1020

atgaagaaca acctgtcgtc tatcctgccc gatttcactg aatccgagaa aaagtttatc     1080

aagggaaccg ctgacttctt cgccctctgt ttcggcccga ccttgtcctt ccaactgctc     1140

gatcctcata tgaagttccg gcagctggaa tcccctaacc ttcgccagct gctgtcctgg     1200

atcgacttgg aattcaacca cccgcagatc ttcattgtcg agaacggctg gttcgtgtcc     1260

gggaccacca agcgcgacga cgccaagtac atgtattatc tcaaaaagtt catcatggaa     1320

accctcaagg ccatcaaatt ggatggcgtg gacgtgatcg gatatacggc gtggagcctg     1380

atggacggtt tcgagtggca ccgcggatac agcatccgca gaggactctt ctacgtggac     1440

ttcctgtcgc aagacaagat gctgctgcct aagagcagcg cgctgttcta ccaaaagctc     1500

attgagaaga acgggttccc gcccctgccg gagaaccagc ctctggaagg gaccttccct     1560

tgcgacttcg cctggggagt ggtcgacaac tacattcaag tgtcccagct tactaagcca     1620

atcagcagcc tgactaagcc ataccacggc gggggagggt cgggcggagg cggatccgac     1680

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc     1740

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc     1800

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc     1860

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgg     1920

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc     1980

aaggtcagca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     2040

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac     2100

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     2160

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     2220

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     2280

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagtccctc     2340

tccctgtctc cgggtaaa                                                   2358


<210>  89
<211>  99
<212>  DNA
<213>  Homo sapiens

<400>  89
atgcctgctt ccgccccgcc tagaaggcct cggcctcctc cccccagcct gtctctgctc       60

ttggtgctgc tgggactggg tggacggcgc cttcgcgca                              99


<210>  90
<211>  99
<212>  DNA
<213>  Homo sapiens

<400>  90
atgccagctt ccgccccccc tcggcggcct agacccccac ctccctccct gtcgctgctg       60

ctggtgctgc tcggtctggg cggacggaga ctcagggcc                              99


<210>  91
<211>  2844
<212>  DNA
<213>  Homo sapiens

<400>  91
gagcctggcg acggcgccca gacctgggcc cgggtgtcga ggccgccagc gcccgaggcc       60

gccggactgt tccagggaac cttccctgat gggttcctct gggccgtggg ctcagccgca      120

taccagaccg aggggggctg gcagcagcac ggaaagggcg ccagcatatg ggacacgttc      180

acccaccacc cgctggctcc gcccggggac tccagaaacg cctccttgcc cctcggtgct      240

ccttcgccac tgcaacccgc aaccggcgac gtggccagcg attcatacaa caacgtgttc      300

cgggacaccg aggccctgag ggaactggga gtgactcact accgcttttc gatctcctgg      360

gcacgcgtgc tcccgaacgg atcggcggga gtgccgaatc gcgagggcct gcggtactac      420

cgacggctgc tggaaaggct cagagaactg ggcgtgcagc ctgtcgtgac tctttaccac      480

tgggatctgc cccaacggct gcaggatgct tacgggggat gggccaatag agccctggct      540

gatcacttcc gcgactacgc cgaattgtgc ttccggcact tcggtggcca agtcaagtac      600

tggattacca tcgacaaccc atacgtcgtg gcgtggcacg gatacgcaac cggtcggctg      660

gcccctggta ttcgcgggtc cccgcggctt ggatacctgg tggcccacaa cctgttgctc      720

gcgcatgcca aagtctggca cctgtacaac acctcgttcc ggccgaccca gggtggacaa      780

gtgtccatcg ccctgtcgtc acactggatc aacccgcgga gaatgaccga ccactccatc      840

aaggaatgcc agaagtccct cgatttcgtg ttgggctggt ttgccaagcc tgtgtttatt      900

gacggagact accccgagtc catgaagaac aacctgtcgt ctatcctgcc cgatttcact      960

gaatccgaga aaaagtttat caagggaacc gctgacttct tcgccctctg tttcggcccg     1020

accttgtcct tccaactgct cgatcctcat atgaagttcc ggcagctgga atcccctaac     1080

cttcgccagc tgctgtcctg gatcgacttg gaattcaacc acccgcagat cttcattgtc     1140

gagaacggct ggttcgtgtc cgggaccacc aagcgcgacg acgccaagta catgtattat     1200

ctcaaaaagt tcatcatgga aaccctcaag gccatcaaat tggatggcgt ggacgtgatc     1260

ggatatacgg cgtggagcct gatggacggt ttcgagtggc accgcggata cagcatccgc     1320

agaggactct tctacgtgga cttcctgtcg caagacaaga tgctgctgcc taagagcagc     1380

gcgctgttct accaaaagct cattgagaag aacgggttcc cgcccctgcc ggagaaccag     1440

cctctggaag ggaccttccc ttgcgacttc gcctggggag tggtggacaa ctacatccag     1500

gtcgatacca ctctgagcca gttcaccgac ctgaacgtgt acctgtggga cgtgcatcac     1560

agcaagaggc tcattaaggt cgacggagtg gtcaccaaga agagaaagtc gtactgcgtg     1620

gatttcgccg caatccagcc acagatcgcc ctgctgcaag agatgcacgt gacccatttc     1680

cgcttctccc tggattgggc cctgattctc ccgctgggga accagtcgca agtgaaccac     1740

actatcctgc aatactaccg gtgcatggct tccgagctcg tccgcgtgaa tatcaccccc     1800

gtggtggcgc tctggcagcc tatggccccg aaccagggac tgccacgact gctggccaga     1860

cagggagcgt gggaaaaccc gtacacagca ctggcctttg cggagtacgc ccggctgtgc     1920

ttccaggaac ttgggcatca cgtcaagctt tggattacta tgaacgaacc ctacactagg     1980

aacatgactt actcagccgg acataacctt ctgaaggcac acgccctcgc ttggcacgtg     2040

tacaacgaaa agttcagaca cgctcagaac ggaaagattt ccatcgcgct gcaagcagac     2100

tggatcgagc ccgcctgccc tttctcccaa aaagacaagg aagtggccga acgggtgctg     2160

gaattcgaca tcggatggct ggccgaaccc atcttcggct ccggcgatta tccatgggtc     2220

atgcgggact ggctcaacca gcgcaacaac tttttgctgc catacttcac cgaagatgag     2280

aagaagctga tccagggcac ctttgatttc ctggcgctga gccactacac tacgattctg     2340

gtggacagcg aaaaggagga cccgattaag tacaacgact acctggaagt ccaggaaatg     2400

accgatatta cttggctgaa ctcacctagc caagtggcgg tggtgccttg gggactgaga     2460

aaggtcctca actggctcaa attcaaatac ggagatctgc ccatgtacat catctccaat     2520

gggatcgacg acggcctgca tgctgaggac gatcagctcc gcgtgtacta tatgcagaac     2580

tacattaacg aggcactgaa ggcccatatt ctggacggca ttaacctctg cggttatttt     2640

gcctactcgt tcaacgaccg gactgccccc cgcttcgggt tgtaccgcta cgccgcggat     2700

cagtttgagc caaaggcctc catgaagcat taccgcaaga tcattgattc caatggattt     2760

ccgggccccg aaaccctcga acggttctgt ccggaagagt tcaccgtgtg taccgagtgc     2820

tccttctttc acacccgcaa gagc                                            2844


<210>  92
<211>  1548
<212>  DNA
<213>  Homo sapiens

<400>  92
gagcctggcg acggcgcaca gacctgggcc cggttctcac gccccccggc cccggaagcc       60

gccggactgt ttcagggaac cttccccgac ggattcctgt gggccgtggg tagcgcggcg      120

taccagactg agggcggatg gcagcagcac ggaaagggag cctcaatttg ggatactttc      180

actcatcatc ccctcgcccc gccgggggat tcgcggaacg cctccctccc cctgggtgct      240

cctagcccgc tgcagccagc caccggcgac gtggcatccg acagctacaa caacgtgttc      300

cgggacaccg aggccctgag ggaactggga gtgactcact accgcttttc gatctcctgg      360

gcacgcgtgc tcccgaacgg atcggcggga gtgccgaatc gcgagggcct gcggtactac      420

cgacggctgc tggaaaggct cagagaactg ggcgtgcagc ctgtcgtgac tctttaccac      480

tgggatctgc cccaacggct gcaggatgct tacgggggat gggccaatag agccctggct      540

gatcacttcc gcgactacgc cgaattgtgc ttccggcact tcggtggcca agtcaagtac      600

tggattacca tcgacaaccc atacgtcgtg gcgtggcacg gatacgcaac cggtcggctg      660

gcccctggta ttcgcgggtc cccgcggctt ggatacctgg tggcccacaa cctgttgctc      720

gcgcatgcca aagtctggca cctgtacaac acctcgttcc ggccgaccca gggtggacaa      780

gtgtccatcg ccctgtcgtc acactggatc aacccgcgga gaatgaccga ccactccatc      840

aaggaatgcc agaagtccct cgatttcgtg ttgggctggt ttgccaagcc tgtgtttatt      900

gacggagact accccgagtc catgaagaac aacctgtcgt ctatcctgcc cgatttcact      960

gaatccgaga aaaagtttat caagggaacc gctgacttct tcgccctctg tttcggcccg     1020

accttgtcct tccaactgct cgatcctcat atgaagttcc ggcagctgga atcccctaac     1080

cttcgccagc tgctgtcctg gatcgacttg gaattcaacc acccgcagat cttcattgtc     1140

gagaacggct ggttcgtgtc cgggaccacc aagcgcgacg acgccaagta catgtattat     1200

ctcaaaaagt tcatcatgga aaccctcaag gccatcaaat tggatggcgt ggacgtgatc     1260

ggatatacgg cgtggagcct gatggacggt ttcgagtggc accgcggata cagcatccgc     1320

agaggactct tctacgtgga cttcctgtcg caagacaaga tgctgctgcc taagagcagc     1380

gcgctgttct accaaaagct cattgagaag aacgggttcc cgcccctgcc ggagaaccag     1440

cctctggaag ggaccttccc ttgcgacttc gcctggggag tggtcgacaa ctacattcaa     1500

gtgtcccagc ttactaagcc aatcagcagc ctgactaagc cataccac                  1548


<210>  93
<211>  2838
<212>  DNA
<213>  Homo sapiens

<400>  93
ggcgacggcg cccagacctg ggcccgggtg tcgaggccgc cagcgcccga ggccgccgga       60

ctgttccagg gaaccttccc tgatgggttc ctctgggccg tgggctcagc cgcataccag      120

accgaggggg gctggcagca gcacggaaag ggcgccagca tatgggacac gttcacccac      180

cacccgctgg ctccgcccgg ggactccaga aacgcctcct tgcccctcgg tgctccttcg      240

ccactgcaac ccgcaaccgg cgacgtggcc agcgattcat acaacaacgt gttccgggac      300

accgaggccc tgagggaact gggagtgact cactaccgct tttcgatctc ctgggcacgc      360

gtgctcccga acggatcggc gggagtgccg aatcgcgagg gcctgcggta ctaccgacgg      420

ctgctggaaa ggctcagaga actgggcgtg cagcctgtcg tgactcttta ccactgggat      480

ctgccccaac ggctgcagga tgcttacggg ggatgggcca atagagccct ggctgatcac      540

ttccgcgact acgccgaatt gtgcttccgg cacttcggtg gccaagtcaa gtactggatt      600

accatcgaca acccatacgt cgtggcgtgg cacggatacg caaccggtcg gctggcccct      660

ggtattcgcg ggtccccgcg gcttggatac ctggtggccc acaacctgtt gctcgcgcat      720

gccaaagtct ggcacctgta caacacctcg ttccggccga cccagggtgg acaagtgtcc      780

atcgccctgt cgtcacactg gatcaacccg cggagaatga ccgaccactc catcaaggaa      840

tgccagaagt ccctcgattt cgtgttgggc tggtttgcca agcctgtgtt tattgacgga      900

gactaccccg agtccatgaa gaacaacctg tcgtctatcc tgcccgattt cactgaatcc      960

gagaaaaagt ttatcaaggg aaccgctgac ttcttcgccc tctgtttcgg cccgaccttg     1020

tccttccaac tgctcgatcc tcatatgaag ttccggcagc tggaatcccc taaccttcgc     1080

cagctgctgt cctggatcga cttggaattc aaccacccgc agatcttcat tgtcgagaac     1140

ggctggttcg tgtccgggac caccaagcgc gacgacgcca agtacatgta ttatctcaaa     1200

aagttcatca tggaaaccct caaggccatc aaattggatg gcgtggacgt gatcggatat     1260

acggcgtgga gcctgatgga cggtttcgag tggcaccgcg gatacagcat ccgcagagga     1320

ctcttctacg tggacttcct gtcgcaagac aagatgctgc tgcctaagag cagcgcgctg     1380

ttctaccaaa agctcattga gaagaacggg ttcccgcccc tgccggagaa ccagcctctg     1440

gaagggacct tcccttgcga cttcgcctgg ggagtggtgg acaactacat ccaggtcgat     1500

accactctga gccagttcac cgacctgaac gtgtacctgt gggacgtgca tcacagcaag     1560

aggctcatta aggtcgacgg agtggtcacc aagaagagaa agtcgtactg cgtggatttc     1620

gccgcaatcc agccacagat cgccctgctg caagagatgc acgtgaccca tttccgcttc     1680

tccctggatt gggccctgat tctcccgctg gggaaccagt cgcaagtgaa ccacactatc     1740

ctgcaatact accggtgcat ggcttccgag ctcgtccgcg tgaatatcac ccccgtggtg     1800

gcgctctggc agcctatggc cccgaaccag ggactgccac gactgctggc cagacaggga     1860

gcgtgggaaa acccgtacac agcactggcc tttgcggagt acgcccggct gtgcttccag     1920

gaacttgggc atcacgtcaa gctttggatt actatgaacg aaccctacac taggaacatg     1980

acttactcag ccggacataa ccttctgaag gcacacgccc tcgcttggca cgtgtacaac     2040

gaaaagttca gacacgctca gaacggaaag atttccatcg cgctgcaagc agactggatc     2100

gagcccgcct gccctttctc ccaaaaagac aaggaagtgg ccgaacgggt gctggaattc     2160

gacatcggat ggctggccga acccatcttc ggctccggcg attatccatg ggtcatgcgg     2220

gactggctca accagcgcaa caactttttg ctgccatact tcaccgaaga tgagaagaag     2280

ctgatccagg gcacctttga tttcctggcg ctgagccact acactacgat tctggtggac     2340

agcgaaaagg aggacccgat taagtacaac gactacctgg aagtccagga aatgaccgat     2400

attacttggc tgaactcacc tagccaagtg gcggtggtgc cttggggact gagaaaggtc     2460

ctcaactggc tcaaattcaa atacggagat ctgcccatgt acatcatctc caatgggatc     2520

gacgacggcc tgcatgctga ggacgatcag ctccgcgtgt actatatgca gaactacatt     2580

aacgaggcac tgaaggccca tattctggac ggcattaacc tctgcggtta ttttgcctac     2640

tcgttcaacg accggactgc cccccgcttc gggttgtacc gctacgccgc ggatcagttt     2700

gagccaaagg cctccatgaa gcattaccgc aagatcattg attccaatgg atttccgggc     2760

cccgaaaccc tcgaacggtt ctgtccggaa gagttcaccg tgtgtaccga gtgctccttc     2820

tttcacaccc gcaagagc                                                   2838


<210>  94
<211>  1542
<212>  DNA
<213>  Homo sapiens

<400>  94
ggcgacggcg cacagacctg ggcccggttc tcacgccccc cggccccgga agccgccgga       60

ctgtttcagg gaaccttccc cgacggattc ctgtgggccg tgggtagcgc ggcgtaccag      120

actgagggcg gatggcagca gcacggaaag ggagcctcaa tttgggatac tttcactcat      180

catcccctcg ccccgccggg ggattcgcgg aacgcctccc tccccctggg tgctcctagc      240

ccgctgcagc cagccaccgg cgacgtggca tccgacagct acaacaacgt gttccgggac      300

accgaggccc tgagggaact gggagtgact cactaccgct tttcgatctc ctgggcacgc      360

gtgctcccga acggatcggc gggagtgccg aatcgcgagg gcctgcggta ctaccgacgg      420

ctgctggaaa ggctcagaga actgggcgtg cagcctgtcg tgactcttta ccactgggat      480

ctgccccaac ggctgcagga tgcttacggg ggatgggcca atagagccct ggctgatcac      540

ttccgcgact acgccgaatt gtgcttccgg cacttcggtg gccaagtcaa gtactggatt      600

accatcgaca acccatacgt cgtggcgtgg cacggatacg caaccggtcg gctggcccct      660

ggtattcgcg ggtccccgcg gcttggatac ctggtggccc acaacctgtt gctcgcgcat      720

gccaaagtct ggcacctgta caacacctcg ttccggccga cccagggtgg acaagtgtcc      780

atcgccctgt cgtcacactg gatcaacccg cggagaatga ccgaccactc catcaaggaa      840

tgccagaagt ccctcgattt cgtgttgggc tggtttgcca agcctgtgtt tattgacgga      900

gactaccccg agtccatgaa gaacaacctg tcgtctatcc tgcccgattt cactgaatcc      960

gagaaaaagt ttatcaaggg aaccgctgac ttcttcgccc tctgtttcgg cccgaccttg     1020

tccttccaac tgctcgatcc tcatatgaag ttccggcagc tggaatcccc taaccttcgc     1080

cagctgctgt cctggatcga cttggaattc aaccacccgc agatcttcat tgtcgagaac     1140

ggctggttcg tgtccgggac caccaagcgc gacgacgcca agtacatgta ttatctcaaa     1200

aagttcatca tggaaaccct caaggccatc aaattggatg gcgtggacgt gatcggatat     1260

acggcgtgga gcctgatgga cggtttcgag tggcaccgcg gatacagcat ccgcagagga     1320

ctcttctacg tggacttcct gtcgcaagac aagatgctgc tgcctaagag cagcgcgctg     1380

ttctaccaaa agctcattga gaagaacggg ttcccgcccc tgccggagaa ccagcctctg     1440

gaagggacct tcccttgcga cttcgcctgg ggagtggtcg acaactacat tcaagtgtcc     1500

cagcttacta agccaatcag cagcctgact aagccatacc ac                        1542


<210>  95
<211>  2553
<212>  DNA
<213>  Homo sapiens

<400>  95
aacgtgttcc gggacaccga ggccctgagg gaactgggag tgactcacta ccgcttttcg       60

atctcctggg cacgcgtgct cccgaacgga tcggcgggag tgccgaatcg cgagggcctg      120

cggtactacc gacggctgct ggaaaggctc agagaactgg gcgtgcagcc tgtcgtgact      180

ctttaccact gggatctgcc ccaacggctg caggatgctt acgggggatg ggccaataga      240

gccctggctg atcacttccg cgactacgcc gaattgtgct tccggcactt cggtggccaa      300

gtcaagtact ggattaccat cgacaaccca tacgtcgtgg cgtggcacgg atacgcaacc      360

ggtcggctgg cccctggtat tcgcgggtcc ccgcggcttg gatacctggt ggcccacaac      420

ctgttgctcg cgcatgccaa agtctggcac ctgtacaaca cctcgttccg gccgacccag      480

ggtggacaag tgtccatcgc cctgtcgtca cactggatca acccgcggag aatgaccgac      540

cactccatca aggaatgcca gaagtccctc gatttcgtgt tgggctggtt tgccaagcct      600

gtgtttattg acggagacta ccccgagtcc atgaagaaca acctgtcgtc tatcctgccc      660

gatttcactg aatccgagaa aaagtttatc aagggaaccg ctgacttctt cgccctctgt      720

ttcggcccga ccttgtcctt ccaactgctc gatcctcata tgaagttccg gcagctggaa      780

tcccctaacc ttcgccagct gctgtcctgg atcgacttgg aattcaacca cccgcagatc      840

ttcattgtcg agaacggctg gttcgtgtcc gggaccacca agcgcgacga cgccaagtac      900

atgtattatc tcaaaaagtt catcatggaa accctcaagg ccatcaaatt ggatggcgtg      960

gacgtgatcg gatatacggc gtggagcctg atggacggtt tcgagtggca ccgcggatac     1020

agcatccgca gaggactctt ctacgtggac ttcctgtcgc aagacaagat gctgctgcct     1080

aagagcagcg cgctgttcta ccaaaagctc attgagaaga acgggttccc gcccctgccg     1140

gagaaccagc ctctggaagg gaccttccct tgcgacttcg cctggggagt ggtggacaac     1200

tacatccagg tcgataccac tctgagccag ttcaccgacc tgaacgtgta cctgtgggac     1260

gtgcatcaca gcaagaggct cattaaggtc gacggagtgg tcaccaagaa gagaaagtcg     1320

tactgcgtgg atttcgccgc aatccagcca cagatcgccc tgctgcaaga gatgcacgtg     1380

acccatttcc gcttctccct ggattgggcc ctgattctcc cgctggggaa ccagtcgcaa     1440

gtgaaccaca ctatcctgca atactaccgg tgcatggctt ccgagctcgt ccgcgtgaat     1500

atcacccccg tggtggcgct ctggcagcct atggccccga accagggact gccacgactg     1560

ctggccagac agggagcgtg ggaaaacccg tacacagcac tggcctttgc ggagtacgcc     1620

cggctgtgct tccaggaact tgggcatcac gtcaagcttt ggattactat gaacgaaccc     1680

tacactagga acatgactta ctcagccgga cataaccttc tgaaggcaca cgccctcgct     1740

tggcacgtgt acaacgaaaa gttcagacac gctcagaacg gaaagatttc catcgcgctg     1800

caagcagact ggatcgagcc cgcctgccct ttctcccaaa aagacaagga agtggccgaa     1860

cgggtgctgg aattcgacat cggatggctg gccgaaccca tcttcggctc cggcgattat     1920

ccatgggtca tgcgggactg gctcaaccag cgcaacaact ttttgctgcc atacttcacc     1980

gaagatgaga agaagctgat ccagggcacc tttgatttcc tggcgctgag ccactacact     2040

acgattctgg tggacagcga aaaggaggac ccgattaagt acaacgacta cctggaagtc     2100

caggaaatga ccgatattac ttggctgaac tcacctagcc aagtggcggt ggtgccttgg     2160

ggactgagaa aggtcctcaa ctggctcaaa ttcaaatacg gagatctgcc catgtacatc     2220

atctccaatg ggatcgacga cggcctgcat gctgaggacg atcagctccg cgtgtactat     2280

atgcagaact acattaacga ggcactgaag gcccatattc tggacggcat taacctctgc     2340

ggttattttg cctactcgtt caacgaccgg actgcccccc gcttcgggtt gtaccgctac     2400

gccgcggatc agtttgagcc aaaggcctcc atgaagcatt accgcaagat cattgattcc     2460

aatggatttc cgggccccga aaccctcgaa cggttctgtc cggaagagtt caccgtgtgt     2520

accgagtgct ccttctttca cacccgcaag agc                                  2553


<210>  96
<211>  1257
<212>  DNA
<213>  Homo sapiens

<400>  96
aacgtgttcc gggacaccga ggccctgagg gaactgggag tgactcacta ccgcttttcg       60

atctcctggg cacgcgtgct cccgaacgga tcggcgggag tgccgaatcg cgagggcctg      120

cggtactacc gacggctgct ggaaaggctc agagaactgg gcgtgcagcc tgtcgtgact      180

ctttaccact gggatctgcc ccaacggctg caggatgctt acgggggatg ggccaataga      240

gccctggctg atcacttccg cgactacgcc gaattgtgct tccggcactt cggtggccaa      300

gtcaagtact ggattaccat cgacaaccca tacgtcgtgg cgtggcacgg atacgcaacc      360

ggtcggctgg cccctggtat tcgcgggtcc ccgcggcttg gatacctggt ggcccacaac      420

ctgttgctcg cgcatgccaa agtctggcac ctgtacaaca cctcgttccg gccgacccag      480

ggtggacaag tgtccatcgc cctgtcgtca cactggatca acccgcggag aatgaccgac      540

cactccatca aggaatgcca gaagtccctc gatttcgtgt tgggctggtt tgccaagcct      600

gtgtttattg acggagacta ccccgagtcc atgaagaaca acctgtcgtc tatcctgccc      660

gatttcactg aatccgagaa aaagtttatc aagggaaccg ctgacttctt cgccctctgt      720

ttcggcccga ccttgtcctt ccaactgctc gatcctcata tgaagttccg gcagctggaa      780

tcccctaacc ttcgccagct gctgtcctgg atcgacttgg aattcaacca cccgcagatc      840

ttcattgtcg agaacggctg gttcgtgtcc gggaccacca agcgcgacga cgccaagtac      900

atgtattatc tcaaaaagtt catcatggaa accctcaagg ccatcaaatt ggatggcgtg      960

gacgtgatcg gatatacggc gtggagcctg atggacggtt tcgagtggca ccgcggatac     1020

agcatccgca gaggactctt ctacgtggac ttcctgtcgc aagacaagat gctgctgcct     1080

aagagcagcg cgctgttcta ccaaaagctc attgagaaga acgggttccc gcccctgccg     1140

gagaaccagc ctctggaagg gaccttccct tgcgacttcg cctggggagt ggtcgacaac     1200

tacattcaag tgtcccagct tactaagcca atcagcagcc tgactaagcc ataccac        1257


<210>  97
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA_GS_linker1

<400>  97
gggggtggcg gaagcggtgg cggaggaagc                                        30


<210>  98
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA_GS_Linker_iso2

<400>  98
ggcgggggag ggtcgggcgg aggcggatcc                                        30


<210>  99
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA_ IgG1_noCH1_Fc_Fusion

<400>  99
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgggtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtca gcaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag      420

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagtcc      660

ctctccctgt ctccgggtaa a                                                681


<210>  100
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA_Synthetic_SS

<400>  100
atggctcggc tgacagtcct ggccctgctg gctggtctgc tggcgtcctc gagggcc          57


<210>  101
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA_TwinStrep_tag

<400>  101
ggcggagaaa acctttactt ccaatcctct gcctggagcc acccccagtt tgaaaagggc       60

ggcggctcag ggggcggatc cgggggatca tccgcctggt cccatccgca attcgagaag      120


<210>  102
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_TwinStrep_Tag_2

<400>  102

Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            20                  25                  30          


<210>  103
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_TwinStrep_Tag_3

<400>  103

Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Ser Ser Ala Trp Ser His Pro Gln Phe Glu Lys 
            20                  25                  


<210>  104
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Strep_Tag

<400>  104

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_Strep_Tag_Linker

<400>  105

Gly Gly Glu Asn Leu Tyr Phe Gln Ser Ser Ala 
1               5                   10      


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_Strep_Tag_Linker_2

<400>  106

Gly Gly Glu Asn Leu Tyr Phe Gln 
1               5               


<210>  107
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  107

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr 
            500                 505                 510         


Lys Pro Tyr His 
        515     


<210>  108
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  108

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr 
            500                 505                 510         


Lys Pro Tyr His 
        515     


<210>  109
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  109

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr 
            500                 505                 510         


Lys Pro Tyr His 
        515     


<210>  110
<211>  516
<212>  PRT
<213>  Homo sapiens

<400>  110

Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
1               5                   10                  15      


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
            20                  25                  30          


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
        35                  40                  45              


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
    50                  55                  60                  


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
65                  70                  75                  80  


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
                85                  90                  95      


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
            100                 105                 110         


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
        115                 120                 125             


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
    130                 135                 140                 


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
145                 150                 155                 160 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
                165                 170                 175     


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
            180                 185                 190         


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
        195                 200                 205             


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
    210                 215                 220                 


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
225                 230                 235                 240 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
                245                 250                 255     


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
            260                 265                 270         


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
        275                 280                 285             


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
    290                 295                 300                 


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
305                 310                 315                 320 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
                325                 330                 335     


Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
            340                 345                 350         


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
        355                 360                 365             


Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp 
    370                 375                 380                 


Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr 
385                 390                 395                 400 


Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly 
                405                 410                 415     


Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu 
            420                 425                 430         


Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe 
        435                 440                 445             


Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr 
    450                 455                 460                 


Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln 
465                 470                 475                 480 


Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp 
                485                 490                 495     


Asn Tyr Ile Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr 
            500                 505                 510         


Lys Pro Tyr His 
        515     


<210>  111
<211>  864
<212>  PRT
<213>  Canis familiaris

<400>  111

Met Ala Thr Cys Ile Leu Gln Met Arg Phe Leu Arg Leu Gly Lys Ile 
1               5                   10                  15      


Leu Phe His Ser Ser Pro Gln Ser Thr Gly Gly Ser Gly Gly Thr Arg 
            20                  25                  30          


Gly Pro Arg Ala Pro Ala Gln Leu Arg Thr Gln Arg Gly Thr Asp Lys 
        35                  40                  45              


Leu Val Ala Lys Ser Glu Leu Lys Ala Lys Thr Ala His Arg Ala Leu 
    50                  55                  60                  


Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe Cys 
65                  70                  75                  80  


Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val Ala 
                85                  90                  95      


Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Val Arg Gly Ser 
            100                 105                 110         


Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His Ala 
        115                 120                 125             


Lys Ile Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly Gly 
    130                 135                 140                 


Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg Met 
145                 150                 155                 160 


Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val Leu 
                165                 170                 175     


Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp Gly Asp Tyr Pro Glu Ser 
            180                 185                 190         


Met Lys Asn Asn Leu Ser Ser Leu Leu Pro Val Phe Thr Glu Ser Glu 
        195                 200                 205             


Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser Phe Gly 
    210                 215                 220                 


Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe His Gln 
225                 230                 235                 240 


Leu Glu Ser Pro Ser Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu Glu 
                245                 250                 255     


Tyr Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val Ser 
            260                 265                 270         


Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys Lys 
        275                 280                 285             


Phe Ile Met Glu Thr Leu Lys Ala Ile Arg Leu Asp Gly Val Asp Val 
    290                 295                 300                 


Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His Arg 
305                 310                 315                 320 


Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser Gln 
                325                 330                 335     


Asp Lys Lys Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys Leu 
            340                 345                 350         


Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu Glu 
        355                 360                 365             


Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Ile Val Asp Asn Tyr Ile 
    370                 375                 380                 


Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Pro Asn Val Tyr Leu 
385                 390                 395                 400 


Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Leu Arg 
                405                 410                 415     


Ala Lys Lys Arg Lys Pro Tyr Cys Val Asp Phe Ala Ala Ile Gly Pro 
            420                 425                 430         


Gln Val Ala Leu Leu Gln Glu Met His Val Ser His Phe His Phe Ser 
        435                 440                 445             


Leu Asp Trp Ala Leu Leu Leu Pro Leu Gly Asn Gln Ser Arg Val Asn 
    450                 455                 460                 


His Ala Ala Leu His Tyr Tyr Gly Cys Val Ala Ser Glu Leu Leu Arg 
465                 470                 475                 480 


Ala Asn Ile Thr Pro Val Val Ala Leu Trp Arg Pro Ala Ala Ala His 
                485                 490                 495     


Gln Gly Leu Pro Gly Pro Leu Ala Gln Arg Gly Ala Trp Glu Asn Pro 
            500                 505                 510         


Arg Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Arg Ala 
        515                 520                 525             


Leu Gly Arg His Val Lys Val Trp Ile Thr Leu Arg Glu Pro Pro Thr 
    530                 535                 540                 


Arg Asn Leu Thr Leu Arg Ala Gly His Asn Leu Leu Arg Ala His Ala 
545                 550                 555                 560 


Leu Ala Trp Arg Val Tyr Asp Glu Gln Phe Arg Gly Ser Gln Gln Gly 
                565                 570                 575     


Lys Val Ser Ile Ala Leu Gln Ala Asp Trp Val Glu Pro Ala Cys Pro 
            580                 585                 590         


Ser Ser Gln Lys Asp Arg Glu Val Ala Glu Arg Val Leu Glu Phe Asp 
        595                 600                 605             


Val Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro Arg 
    610                 615                 620                 


Leu Met Arg Asp Trp Leu Thr Arg Arg Asp His Ser Leu Leu Pro Tyr 
625                 630                 635                 640 


Phe Thr Asp Glu Glu Lys Arg Leu Ile Arg Gly Ser Phe Asp Phe Leu 
                645                 650                 655     


Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Trp Glu Lys Glu Asp 
            660                 665                 670         


Pro Val Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp Ile 
        675                 680                 685             


Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly Leu 
    690                 695                 700                 


Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly Asp Leu Pro Met 
705                 710                 715                 720 


Tyr Ile Val Ser Asn Gly Ile Asp Asp Asp Pro Arg Ala Ala Gln Asp 
                725                 730                 735     


Ser Leu Arg Val Tyr Tyr Met Gln Asn Tyr Val Asn Glu Ala Leu Lys 
            740                 745                 750         


Ala Tyr Val Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr Ser 
        755                 760                 765             


Phe Asn Asp Arg Thr Ala Pro Lys Phe Gly Leu Tyr His Tyr Ala Ala 
    770                 775                 780                 


Asn Gln Phe Glu Pro Lys Pro Ser Val Lys His Tyr Arg Lys Ile Ile 
785                 790                 795                 800 


Asp Asn Asn Gly Phe Pro Gly Pro Glu Thr Leu Gly Arg Phe Cys Pro 
                805                 810                 815     


Glu Glu Phe Thr Leu Cys Thr Glu Cys Ser Phe Phe His Thr Arg Lys 
            820                 825                 830         


Ser Leu Leu Ala Phe Ile Ala Phe Leu Leu Phe Ala Phe Ile Ile Ser 
        835                 840                 845             


Leu Ser Leu Ile Phe Tyr Tyr Ser Arg Lys Gly Arg Arg Ser Tyr Lys 
    850                 855                 860                 


<210>  112
<211>  705
<212>  PRT
<213>  Felis catus

<400>  112

Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
1               5                   10                  15      


Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp Gly Asp Tyr Pro Glu 
            20                  25                  30          


Ser Met Lys Asn Asn Leu Ser His Leu Leu Pro Asp Phe Thr Glu Ala 
        35                  40                  45              


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser Phe 
    50                  55                  60                  


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
65                  70                  75                  80  


Gln Leu Glu Ser Pro Ser Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
                85                  90                  95      


Glu Tyr Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
            100                 105                 110         


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
        115                 120                 125             


Lys Phe Val Met Glu Thr Leu Lys Ala Ile Arg Leu Asp Gly Val Asp 
    130                 135                 140                 


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
145                 150                 155                 160 


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
                165                 170                 175     


Gln Asp Lys Lys Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
            180                 185                 190         


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
        195                 200                 205             


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Ile Val Asp Asn Tyr 
    210                 215                 220                 


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Pro Asn Val Tyr 
225                 230                 235                 240 


Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Val 
                245                 250                 255     


Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Arg 
            260                 265                 270         


Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Ser His Phe His Phe 
        275                 280                 285             


Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val 
    290                 295                 300                 


Asn His Thr Val Leu Asp Tyr Tyr Arg Cys Val Val Ser Glu Leu Val 
305                 310                 315                 320 


Arg Ala Asn Ile Thr Pro Val Val Ala Leu Trp Arg Pro Ala Ala Pro 
                325                 330                 335     


His Gln Gly Leu Pro Arg Pro Leu Ala Lys His Gly Ala Trp Glu Asn 
            340                 345                 350         


Pro His Thr Ala Ser Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Lys 
        355                 360                 365             


Asp Leu Gly His His Val Lys Phe Trp Ile Thr Met Gly Glu Pro Tyr 
    370                 375                 380                 


Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His 
385                 390                 395                 400 


Ala Leu Ala Trp Arg Val Tyr Asp Glu Asn Phe Arg Gly Ser Gln Lys 
                405                 410                 415     


Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys 
            420                 425                 430         


Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe 
        435                 440                 445             


Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro 
    450                 455                 460                 


Arg Val Met Arg Asp Trp Leu Thr Gln Arg Asn Asn Phe Leu Leu Pro 
465                 470                 475                 480 


Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Arg Gly Ser Phe Asp Phe 
                485                 490                 495     


Leu Ala Val Ser His Tyr Thr Thr Ile Leu Val Asp Trp Glu Lys Glu 
            500                 505                 510         


Asp Pro Met Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp 
        515                 520                 525             


Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly 
    530                 535                 540                 


Leu Arg Lys Ile Leu Asn Trp Leu Lys Leu Lys Tyr Gly Asp Leu Pro 
545                 550                 555                 560 


Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Asp Pro Gln Ala Ala Gln 
                565                 570                 575     


Asp Lys Leu Arg Val Tyr Tyr Met Gln Asn Tyr Val Asn Glu Ala Leu 
            580                 585                 590         


Lys Ala Tyr Val Leu Asp Gly Val Asn Leu Cys Gly Tyr Phe Ala Tyr 
        595                 600                 605             


Ser Phe Asn Asp Arg Thr Ala Pro Lys Phe Gly Phe Tyr His Tyr Ala 
    610                 615                 620                 


Ala Asn Gln Phe Glu Pro Lys Pro Ser Met Lys His Tyr Arg Lys Met 
625                 630                 635                 640 


Ile Asp Ser Asn Gly Phe Ser Gly Pro Asp Thr Leu Gly Arg Phe Cys 
                645                 650                 655     


Pro Glu Glu Phe Thr Leu Cys Thr Glu Cys Gly Phe Phe His Thr Arg 
            660                 665                 670         


Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Leu Phe Ala Phe Ile Ile 
        675                 680                 685             


Ser Leu Ser Leu Ile Phe Tyr Tyr Ser Lys Lys Gly Lys Arg Ser Tyr 
    690                 695                 700                 


Lys 
705 


<210>  113
<211>  705
<212>  PRT
<213>  Felis catus

<400>  113

Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val 
1               5                   10                  15      


Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp Gly Asp Tyr Pro Glu 
            20                  25                  30          


Ser Met Lys Asn Asn Leu Ser His Leu Leu Pro Asp Phe Thr Glu Ala 
        35                  40                  45              


Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser Phe 
    50                  55                  60                  


Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg 
65                  70                  75                  80  


Gln Leu Glu Ser Pro Ser Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu 
                85                  90                  95      


Glu Tyr Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val 
            100                 105                 110         


Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys 
        115                 120                 125             


Lys Phe Val Met Glu Thr Leu Lys Ala Ile Arg Leu Asp Gly Val Asp 
    130                 135                 140                 


Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His 
145                 150                 155                 160 


Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser 
                165                 170                 175     


Gln Asp Lys Lys Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys 
            180                 185                 190         


Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu 
        195                 200                 205             


Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Ile Val Asp Asn Tyr 
    210                 215                 220                 


Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Pro Asn Val Tyr 
225                 230                 235                 240 


Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly Val 
                245                 250                 255     


Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Arg 
            260                 265                 270         


Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Ser His Phe His Phe 
        275                 280                 285             


Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln Val 
    290                 295                 300                 


Asn His Thr Val Leu Asp Tyr Tyr Arg Cys Val Val Ser Glu Leu Val 
305                 310                 315                 320 


Arg Ala Asn Ile Thr Pro Val Val Ala Leu Trp Arg Pro Ala Ala Pro 
                325                 330                 335     


His Gln Gly Leu Pro Arg Pro Leu Ala Lys His Gly Ala Trp Glu Asn 
            340                 345                 350         


Pro His Thr Ala Ser Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe Lys 
        355                 360                 365             


Asp Leu Gly His His Val Lys Phe Trp Ile Thr Met Gly Glu Pro Tyr 
    370                 375                 380                 


Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala His 
385                 390                 395                 400 


Ala Leu Ala Trp Arg Val Tyr Asp Glu Asn Phe Arg Gly Ser Gln Lys 
                405                 410                 415     


Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys 
            420                 425                 430         


Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe 
        435                 440                 445             


Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro 
    450                 455                 460                 


Arg Val Met Arg Asp Trp Leu Thr Gln Arg Asn Asn Phe Leu Leu Pro 
465                 470                 475                 480 


Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Arg Gly Ser Phe Asp Phe 
                485                 490                 495     


Leu Ala Val Ser His Tyr Thr Thr Ile Leu Val Asp Trp Glu Lys Glu 
            500                 505                 510         


Asp Pro Met Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp 
        515                 520                 525             


Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp Gly 
    530                 535                 540                 


Leu Arg Lys Ile Leu Asn Trp Leu Lys Leu Lys Tyr Gly Asp Leu Pro 
545                 550                 555                 560 


Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Asp Pro Gln Ala Ala Gln 
                565                 570                 575     


Asp Lys Leu Arg Val Tyr Tyr Met Gln Asn Tyr Val Asn Glu Ala Leu 
            580                 585                 590         


Lys Ala Tyr Val Leu Asp Gly Val Asn Leu Cys Gly Tyr Phe Ala Tyr 
        595                 600                 605             


Ser Phe Asn Asp Arg Thr Ala Pro Lys Phe Gly Phe Tyr His Tyr Ala 
    610                 615                 620                 


Ala Asn Gln Phe Glu Pro Lys Pro Ser Met Lys His Tyr Arg Lys Met 
625                 630                 635                 640 


Ile Asp Ser Asn Gly Phe Ser Gly Pro Asp Thr Leu Gly Arg Phe Cys 
                645                 650                 655     


Pro Glu Glu Phe Thr Leu Cys Thr Glu Cys Gly Phe Phe His Thr Arg 
            660                 665                 670         


Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Leu Phe Ala Phe Ile Ile 
        675                 680                 685             


Ser Leu Ser Leu Ile Phe Tyr Tyr Ser Lys Lys Gly Lys Arg Ser Tyr 
    690                 695                 700                 


Lys 
705 


<210>  114
<211>  754
<212>  PRT
<213>  Felis catus

<400>  114

Met Arg Asp Leu Cys Tyr Ile Thr Trp Ser Arg Gly Thr Val Gln Ala 
1               5                   10                  15      


His Ala Lys Ile Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln 
            20                  25                  30          


Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg 
        35                  40                  45              


Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe 
    50                  55                  60                  


Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp Gly Asp Tyr Pro 
65                  70                  75                  80  


Glu Ser Met Lys Asn Asn Leu Ser His Leu Leu Pro Asp Phe Thr Glu 
                85                  90                  95      


Ala Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser 
            100                 105                 110         


Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe 
        115                 120                 125             


Arg Gln Leu Glu Ser Pro Ser Leu Arg Gln Leu Leu Ser Trp Ile Asp 
    130                 135                 140                 


Leu Glu Tyr Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe 
145                 150                 155                 160 


Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu 
                165                 170                 175     


Lys Lys Phe Val Met Glu Thr Leu Lys Ala Ile Arg Leu Asp Gly Val 
            180                 185                 190         


Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp 
        195                 200                 205             


His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu 
    210                 215                 220                 


Ser Gln Asp Lys Lys Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln 
225                 230                 235                 240 


Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro 
                245                 250                 255     


Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Ile Val Asp Asn 
            260                 265                 270         


Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Pro Asn Val 
        275                 280                 285             


Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val Asp Gly 
    290                 295                 300                 


Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile 
305                 310                 315                 320 


Arg Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Ser His Phe His 
                325                 330                 335     


Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln Ser Gln 
            340                 345                 350         


Val Asn His Thr Val Leu Asp Tyr Tyr Arg Cys Val Val Ser Glu Leu 
        355                 360                 365             


Val Arg Ala Asn Ile Thr Pro Val Val Ala Leu Trp Arg Pro Ala Ala 
    370                 375                 380                 


Pro His Gln Gly Leu Pro Arg Pro Leu Ala Lys His Gly Ala Trp Glu 
385                 390                 395                 400 


Asn Pro His Thr Ala Ser Ala Phe Ala Glu Tyr Ala Arg Leu Cys Phe 
                405                 410                 415     


Lys Asp Leu Gly His His Val Lys Phe Trp Ile Thr Met Gly Glu Pro 
            420                 425                 430         


Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala 
        435                 440                 445             


His Ala Leu Ala Trp Arg Val Tyr Asp Glu Asn Phe Arg Gly Ser Gln 
    450                 455                 460                 


Lys Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala 
465                 470                 475                 480 


Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu 
                485                 490                 495     


Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr 
            500                 505                 510         


Pro Arg Val Met Arg Asp Trp Leu Thr Gln Arg Asn Asn Phe Leu Leu 
        515                 520                 525             


Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Arg Gly Ser Phe Asp 
    530                 535                 540                 


Phe Leu Ala Val Ser His Tyr Thr Thr Ile Leu Val Asp Trp Glu Lys 
545                 550                 555                 560 


Glu Asp Pro Met Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr 
                565                 570                 575     


Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp 
            580                 585                 590         


Gly Leu Arg Lys Ile Leu Asn Trp Leu Lys Leu Lys Tyr Gly Asp Leu 
        595                 600                 605             


Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Asp Pro Gln Ala Ala 
    610                 615                 620                 


Gln Asp Lys Leu Arg Val Tyr Tyr Met Gln Asn Tyr Val Asn Glu Ala 
625                 630                 635                 640 


Leu Lys Ala Tyr Val Leu Asp Gly Val Asn Leu Cys Gly Tyr Phe Ala 
                645                 650                 655     


Tyr Ser Phe Asn Asp Arg Thr Ala Pro Lys Phe Gly Phe Tyr His Tyr 
            660                 665                 670         


Ala Ala Asn Gln Phe Glu Pro Lys Pro Ser Met Lys His Tyr Arg Lys 
        675                 680                 685             


Met Ile Asp Ser Asn Gly Phe Ser Gly Pro Asp Thr Leu Gly Arg Phe 
    690                 695                 700                 


Cys Pro Glu Glu Phe Thr Leu Cys Thr Glu Cys Gly Phe Phe His Thr 
705                 710                 715                 720 


Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Leu Phe Ala Phe Ile 
                725                 730                 735     


Ile Ser Leu Ser Leu Ile Phe Tyr Tyr Ser Lys Lys Gly Lys Arg Ser 
            740                 745                 750         


Tyr Lys 
        


<210>  115
<211>  1012
<212>  PRT
<213>  Sus scrofa

<400>  115

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Phe Phe Ala 
            980                 985                 990         


Ser Ile Ile Ser Leu Ser Leu Ile  Phe Tyr Tyr Ser Lys  Lys Gly Arg 
        995                 1000                 1005             


Arg Ser  Tyr Lys 
    1010         


<210>  116
<211>  1013
<212>  PRT
<213>  Bos taurus

<400>  116

Met Pro Ala Arg Ala Pro Pro Arg Arg Leu Arg Ala Phe Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Leu Trp Leu Leu Leu Leu Ala Leu Gly Gly Arg Pro Leu 
            20                  25                  30          


Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ala Arg 
        35                  40                  45              


Pro Pro Thr Pro Glu Ala Ala Gly Leu Leu His Asp Thr Phe Pro Asp 
    50                  55                  60                  


Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly 
65                  70                  75                  80  


Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His 
                85                  90                  95      


Arg Pro Pro Ala Pro Pro Gly Asp Pro Ser Ala Ala Gly Trp Pro Ser 
            100                 105                 110         


Gly Ala Pro Ser Pro Pro Pro Pro Ala Thr Gly Asp Val Ala Ser Asp 
        115                 120                 125             


Gly Tyr Asn Asn Val Phe Arg Asp Thr Glu Gly Leu Arg Glu Leu Gly 
    130                 135                 140                 


Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn 
145                 150                 155                 160 


Gly Ser Ala Ser Ala Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg 
                165                 170                 175     


Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu 
            180                 185                 190         


Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp 
        195                 200                 205             


Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys 
    210                 215                 220                 


Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn 
225                 230                 235                 240 


Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro 
                245                 250                 255     


Gly Val Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu 
            260                 265                 270         


Leu Leu Ala His Ala Lys Ile Trp His Leu Tyr Asp Thr Ser Phe Arg 
        275                 280                 285             


Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile 
    290                 295                 300                 


Ser Pro Arg Arg Met Thr Glu His Ser Ile Gln Glu Cys Gln Lys Ser 
305                 310                 315                 320 


Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp Gly 
                325                 330                 335     


Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro Asp 
            340                 345                 350         


Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe 
        355                 360                 365             


Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro Gln 
    370                 375                 380                 


Met Lys Phe Arg Gln Leu Glu Ser Pro Ser Leu Arg Gln Leu Leu Ser 
385                 390                 395                 400 


Trp Ile Asp Leu Glu Tyr Asn His Pro Gln Ile Phe Ile Val Glu Asn 
                405                 410                 415     


Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met 
            420                 425                 430         


Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Arg Leu 
        435                 440                 445             


Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly 
    450                 455                 460                 


Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val 
465                 470                 475                 480 


Asp Phe Leu Ser Gln Asp Lys Lys Leu Leu Pro Lys Ser Ser Ala Leu 
                485                 490                 495     


Phe Tyr Gln Lys Leu Ile Glu Asn Asn Gly Phe Pro Pro Leu Pro Glu 
            500                 505                 510         


Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val 
        515                 520                 525             


Val Asp Asn Cys Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Ile Asp 
    530                 535                 540                 


Pro Asn Val Tyr Leu Trp Asp Val His Arg Ser Lys Arg Leu Ile Lys 
545                 550                 555                 560 


Val Asp Gly Val Leu Thr Lys Thr Arg Lys Ser Tyr Cys Val Asp Phe 
                565                 570                 575     


Ala Ala Ile Arg Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr 
            580                 585                 590         


His Phe His Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn 
        595                 600                 605             


Arg Ser Gln Val Asn Arg Thr Val Leu Gly Phe Tyr Arg Cys Val Ala 
    610                 615                 620                 


Ser Glu Leu Val Arg Ala Asn Ile Thr Pro Val Val Ala Leu Trp Arg 
625                 630                 635                 640 


Pro Ala Ala Pro His Gln Gly Leu Pro Ala Pro Leu Ala Arg His Gly 
                645                 650                 655     


Ala Trp Glu Asn Pro His Thr Ala Leu Ala Phe Ala Glu Tyr Ala Ser 
            660                 665                 670         


Leu Cys Phe Gln Asp Leu Gly Arg His Val Lys Phe Trp Ile Thr Met 
        675                 680                 685             


His Glu Pro Ser Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu 
    690                 695                 700                 


Leu Lys Ala His Ala Leu Ala Trp Arg Thr Tyr Asp Glu Arg Phe Arg 
705                 710                 715                 720 


Arg Ser Gln Lys Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile 
                725                 730                 735     


Glu Pro Ala Cys Pro Phe Ser Pro Glu Asp Arg Glu Val Ala Glu Arg 
            740                 745                 750         


Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser 
        755                 760                 765             


Gly Asp Tyr Pro Arg Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn 
    770                 775                 780                 


Phe Leu Leu Pro Tyr Phe Thr Asp Glu Glu Lys Lys Leu Ile Arg Gly 
785                 790                 795                 800 


Ser Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp 
                805                 810                 815     


Trp Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Ala Val Gln 
            820                 825                 830         


Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val 
        835                 840                 845             


Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Ala Lys Tyr 
    850                 855                 860                 


Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Asp Pro 
865                 870                 875                 880 


His Ala Ala Gln Asp Asn Leu Arg Val Tyr Tyr Met Gln Thr Tyr Val 
                885                 890                 895     


Asn Glu Ala Leu Lys Ala Tyr Ile Leu Asp Gly Ile Asn Leu Cys Gly 
            900                 905                 910         


Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Lys Phe Gly Leu 
        915                 920                 925             


Tyr Arg Tyr Ala Ala Asn Gln Phe Glu Pro Lys Pro Ser Met Lys His 
    930                 935                 940                 


Tyr Arg Lys Ile Ile Asp Asn Asn Gly Phe Pro Gly Pro Glu Thr Leu 
945                 950                 955                 960 


Gly Arg Phe Cys Pro Glu Glu Phe Thr Leu Cys Thr Glu Cys Ser Phe 
                965                 970                 975     


Phe His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Leu Phe 
            980                 985                 990         


Ala Phe Val Ile Ser Leu Ser Leu  Ile Phe Tyr Tyr Ser  Lys Lys Gly 
        995                 1000                 1005             


Arg Arg  Gly Tyr Lys 
    1010             


<210>  117
<211>  1010
<212>  PRT
<213>  Ovis aries


<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa can be any naturally occurring amino acid

<400>  117

Met Pro Ala Arg Ala Arg Arg Ala Leu Gly Pro Ser Arg Leu Pro Ala 
1               5                   10                  15      


Ala Ala Ala Arg Leu Trp Leu Leu Leu Pro Gly Leu Gly Arg Pro Ala 
            20                  25                  30          


Leu Arg Ala Arg Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ala 
        35                  40                  45              


Arg Pro Pro Asn Pro Arg Gly Arg Gly Leu Leu His Asp Thr Xaa Pro 
    50                  55                  60                  


Asp Gly Phe Ser Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly 
65                  70                  75                  80  


Gly Trp Gln Gln His Gly Lys Gly Ala Ser His Leu Gly His Val His 
                85                  90                  95      


His Arg Pro Pro Ala Pro Pro Gly Asp Pro Ser Arg Pro Gly Trp Pro 
            100                 105                 110         


Ser Gly Ala Pro Ser Pro Pro Pro Arg Pro Pro Ser Gly Asp Val Ala 
        115                 120                 125             


Ser Asp Gly Tyr Asn Asn Val Phe Arg Asp Thr Glu Gly Leu Arg Glu 
    130                 135                 140                 


Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu 
145                 150                 155                 160 


Pro Asn Gly Ser Ala Ser Ala Pro Asn Arg Glu Gly Leu Arg Tyr Tyr 
                165                 170                 175     


Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val 
            180                 185                 190         


Thr Leu Ser His Trp Ala Leu Pro Gln Leu Leu Gln Asp Ala Tyr Gly 
        195                 200                 205             


Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu 
    210                 215                 220                 


Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile 
225                 230                 235                 240 


Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu 
                245                 250                 255     


Ala Pro Gly Gly Arg Gly Ser Pro Arg Leu His Asn Leu Leu Leu Ala 
            260                 265                 270         


His Ala Lys Ile Trp His Leu Tyr Asp Thr Ser Phe Arg Pro Thr Gln 
        275                 280                 285             


Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Ser Pro Arg 
    290                 295                 300                 


Arg Met Thr Glu His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe 
305                 310                 315                 320 


Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp Gly Asp Tyr Pro 
                325                 330                 335     


Glu Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro Asp Phe Thr Glu 
            340                 345                 350         


Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser 
        355                 360                 365             


Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro Gln Met Lys Phe 
    370                 375                 380                 


Arg Gln Leu Glu Ser Pro Ser Leu Arg Gln Leu Leu Ser Trp Ile Asp 
385                 390                 395                 400 


Leu Glu Tyr Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe 
                405                 410                 415     


Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu 
            420                 425                 430         


Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Arg Leu Asp Gly Val 
        435                 440                 445             


Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp 
    450                 455                 460                 


His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu 
465                 470                 475                 480 


Ser Gln Asp Lys Lys Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln 
                485                 490                 495     


Lys Leu Ile Glu Asn Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro 
            500                 505                 510         


Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn 
        515                 520                 525             


Cys Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Ile Asp Pro Asn Val 
    530                 535                 540                 


Tyr Leu Trp Asp Val His Arg Ser Lys Arg Leu Ile Lys Val Asp Gly 
545                 550                 555                 560 


Val Leu Thr Lys Thr Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile 
                565                 570                 575     


Arg Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His Phe His 
            580                 585                 590         


Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Arg Ser Gln 
        595                 600                 605             


Val Asn Arg Thr Val Leu Gly Phe Tyr Arg Cys Val Ala Ser Glu Leu 
    610                 615                 620                 


Val Arg Ala Asn Ile Thr Pro Val Val Ala Leu Trp Arg Pro Ala Ala 
625                 630                 635                 640 


Pro His Gln Gly Leu Pro Ala Pro Leu Ala Arg His Gly Ala Trp Glu 
                645                 650                 655     


Asn Pro His Thr Ala Leu Ala Phe Ala Glu Tyr Ala Ser Leu Cys Phe 
            660                 665                 670         


Gln Asp Leu Gly Arg His Val Lys Phe Trp Ile Thr Met His Glu Pro 
        675                 680                 685             


Ser Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu Lys Ala 
    690                 695                 700                 


His Ala Leu Ala Trp Arg Thr Tyr Asp Glu Arg Phe Arg Arg Ser Gln 
705                 710                 715                 720 


Lys Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala 
                725                 730                 735     


Cys Pro Phe Ser Pro Glu Asp Arg Glu Val Ala Glu Arg Val Leu Glu 
            740                 745                 750         


Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr 
        755                 760                 765             


Pro Arg Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu 
    770                 775                 780                 


Pro Tyr Phe Thr Asp Glu Glu Lys Lys Leu Ile Arg Gly Ser Phe Asp 
785                 790                 795                 800 


Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Trp Glu Lys 
                805                 810                 815     


Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Ala Val Gln Glu Met Thr 
            820                 825                 830         


Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val Pro Trp 
        835                 840                 845             


Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Ala Lys Tyr Gly Asp Leu 
    850                 855                 860                 


Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Asp Pro His Ala Ala 
865                 870                 875                 880 


Gln Asp Asn Leu Arg Val Tyr Tyr Met Gln Asn Tyr Val Asn Glu Ala 
                885                 890                 895     


Leu Lys Ala Tyr Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala 
            900                 905                 910         


Tyr Ser Phe Asn Asp Arg Thr Ala Pro Lys Phe Gly Leu Tyr Arg Tyr 
        915                 920                 925             


Ala Ala Asn Gln Phe Glu Pro Lys Pro Ser Met Lys His Tyr Arg Lys 
    930                 935                 940                 


Ile Ile Asp Asn Asn Gly Phe Pro Gly Pro Glu Thr Leu Gly Arg Phe 
945                 950                 955                 960 


Cys Pro Glu Glu Phe Thr Leu Cys Thr Glu Cys Ser Phe Phe His Ala 
                965                 970                 975     


Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Leu Phe Ala Phe Val 
            980                 985                 990         


Ile Ser Leu Ser Leu Ile Phe Tyr  Tyr Ser Lys Lys Gly  Arg Arg Gly 
        995                 1000                 1005             


Tyr Lys  
    1010 


<210>  118
<211>  983
<212>  PRT
<213>  Equus caballus


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  118

Met Ser Arg Lys Thr Arg Arg Ala Trp Gly Ser Pro Val His Leu Ser 
1               5                   10                  15      


Ala Arg Ser Pro Ala Pro Glu Pro Arg Gly Leu Leu Thr Ala Ser Phe 
            20                  25                  30          


Pro Asp Gly Phe Leu Xaa Ala Val Ser Ser Ala Ala Tyr Gln Thr Glu 
        35                  40                  45              


Gly Gly Trp Arg Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe 
    50                  55                  60                  


Thr His His Pro Pro Ala Thr Pro Gly Gly Pro Gln Leu Ser Gly Leu 
65                  70                  75                  80  


Pro Ser Gly Gly Pro Ser Pro Ser Pro Leu Ala Thr Gly Asp Val Ala 
                85                  90                  95      


Ser Asp Gly Tyr Asn Asn Val Phe Arg Asp Thr Glu Gly Leu Arg Glu 
            100                 105                 110         


Leu Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu 
        115                 120                 125             


Pro Asn Gly Ser Ala Gly Ala Pro Asn Arg Glu Gly Leu Arg Tyr Tyr 
    130                 135                 140                 


Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val 
145                 150                 155                 160 


Thr Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly 
                165                 170                 175     


Gly Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu 
            180                 185                 190         


Leu Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile 
        195                 200                 205             


Asp Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu 
    210                 215                 220                 


Ala Pro Gly Val Arg Gly Ser Pro Gln Leu Gly Tyr Leu Val Ala His 
225                 230                 235                 240 


Asn Leu Leu Leu Ala His Ala Lys Ile Trp His Leu Tyr Asn Thr Ser 
                245                 250                 255     


Phe Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His 
            260                 265                 270         


Trp Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln 
        275                 280                 285             


Lys Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile 
    290                 295                 300                 


Asp Gly Asp Tyr Pro Glu Thr Met Lys Asn Asn Leu Ser Ser Leu Leu 
305                 310                 315                 320 


Pro Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp 
                325                 330                 335     


Phe Phe Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp 
            340                 345                 350         


Pro His Met Lys Phe Arg Gln Leu Glu Ser Pro Ser Leu Arg Gln Leu 
        355                 360                 365             


Leu Ser Trp Ile Asp Leu Glu Tyr Asn His Pro Gln Ile Phe Ile Val 
    370                 375                 380                 


Glu Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys 
385                 390                 395                 400 


Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile 
                405                 410                 415     


Arg Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met 
            420                 425                 430         


Asp Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe 
        435                 440                 445             


Tyr Val Asp Phe Leu Ser Gln Asp Lys Lys Leu Leu Pro Lys Ser Ser 
    450                 455                 460                 


Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu 
465                 470                 475                 480 


Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp 
                485                 490                 495     


Gly Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe 
            500                 505                 510         


Thr Asp Pro Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu 
        515                 520                 525             


Ile Lys Val Asp Gly Leu Val Ala Lys Lys Arg Thr Ser Tyr Cys Val 
    530                 535                 540                 


Asp Phe Ala Ala Ile Arg Pro Gln Ile Ala Leu Leu Gln Glu Met His 
545                 550                 555                 560 


Val Ser His Phe His Phe Ala Leu Asp Trp Pro Leu Ile Leu Pro Leu 
                565                 570                 575     


Gly Asn Gln Ser Gln Val Asn Arg Thr Gly Leu His Tyr Tyr Arg Cys 
            580                 585                 590         


Val Val Ser Glu Leu Val Arg Ala Asn Ile Thr Pro Val Val Ala Leu 
        595                 600                 605             


Trp Arg Pro Ser Pro Gln His Gln Gly Leu Pro Arg Leu Leu Ala Lys 
    610                 615                 620                 


His Gly Ala Trp Glu Asn Pro His Thr Ala Leu Ala Phe Ala Glu Tyr 
625                 630                 635                 640 


Ala Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Phe Trp Ile 
                645                 650                 655     


Thr Met Ser Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His 
            660                 665                 670         


Asn Leu Leu Lys Ala His Ala Leu Ala Trp Arg Val Tyr Asp Asp Lys 
        675                 680                 685             


Phe Arg His Ala Gln Lys Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp 
    690                 695                 700                 


Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln Gln Asp Lys Glu Gly Ala 
705                 710                 715                 720 


Glu Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe 
                725                 730                 735     


Gly Ser Gly Asp Tyr Pro Pro Val Met Arg Asp Trp Leu Asn Gln Arg 
            740                 745                 750         


Asn Asn Phe Leu Leu Pro Tyr Phe Ser Glu Glu Glu Lys Lys Leu Ile 
        755                 760                 765             


Arg Gly Ser Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu 
    770                 775                 780                 


Val Asp Trp Glu Lys Glu Asp Pro Met Lys Tyr Asn Asp Tyr Leu Glu 
785                 790                 795                 800 


Val Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val 
                805                 810                 815     


Ala Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Ser 
            820                 825                 830         


Lys Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ala Asn Gly Ile Asp Asp 
        835                 840                 845             


Asp Pro Gln Glu Ala Gln Asp Arg Leu Arg Val Tyr Tyr Met Gln Asn 
    850                 855                 860                 


Tyr Val Asn Glu Ala Leu Lys Ala Tyr Val Leu Asp Gly Ile Asn Leu 
865                 870                 875                 880 


Cys Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Lys Phe 
                885                 890                 895     


Gly Leu Tyr Arg Tyr Ala Ala Asn Gln Phe Glu Pro Lys Pro Ser Met 
            900                 905                 910         


Lys His Tyr Arg Lys Ile Ile Asp Asn Asn Gly Phe Pro Gly Pro Lys 
        915                 920                 925             


Thr Leu Gly Arg Phe Cys Pro Glu Glu Phe Thr Leu Cys Thr Glu Cys 
    930                 935                 940                 


Ser Phe Phe His Thr Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu 
945                 950                 955                 960 


Leu Phe Ala Phe Ile Ile Ser Leu Ser Leu Ile Phe Tyr Tyr Ser Lys 
                965                 970                 975     


Lys Gly Arg Arg Asn Tyr Lys 
            980             


<210>  119
<211>  1005
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  119

Met Pro Val Arg Ala Arg Pro Leu Gln Leu Arg Leu Arg Leu Leu Leu 
1               5                   10                  15      


Leu Ala Leu Val Gly Arg Leu Leu Arg Ala Glu Pro Gly Asp Gly Ala 
            20                  25                  30          


Gln Thr Trp Val Arg Phe Ala Arg Pro Pro Val Pro Asp Ala Ala Gly 
        35                  40                  45              


Leu Leu His Asp Thr Phe Pro Asp Gly Phe Leu Trp Ala Val Gly Ser 
    50                  55                  60                  


Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His Gly Lys Gly Glu 
65                  70                  75                  80  


Ser Ile Trp Asp Thr Phe Thr His His Pro Pro Ala Pro Leu Gly Asp 
                85                  90                  95      


Leu Ser Ile Thr Pro Leu Pro Ser Gly Thr Pro Ser Ala Pro Pro Ala 
            100                 105                 110         


Ala Thr Gly Asp Val Ala Ser Asp Gly Tyr Asn Asn Val Leu Arg Asp 
        115                 120                 125             


Thr Glu Gly Leu Arg Glu Leu Gly Val Thr His Tyr Arg Phe Ser Ile 
    130                 135                 140                 


Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Ser Ala Pro Asn Arg 
145                 150                 155                 160 


Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg Leu Arg Glu Leu 
                165                 170                 175     


Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp Leu Pro Gln Arg 
            180                 185                 190         


Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Pro Ser Leu Ala Asp His 
        195                 200                 205             


Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe Gly Ser Gln Val 
    210                 215                 220                 


Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val Ala Trp His Gly 
225                 230                 235                 240 


Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly Gly Ala Arg Leu 
                245                 250                 255     


Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His Ala Lys Ile Trp 
            260                 265                 270         


His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly Gly Gln Val Ser 
        275                 280                 285             


Ile Ala Leu Gly Ser His Trp Ile Ile Pro Arg Arg Arg Thr Asp His 
    290                 295                 300                 


Asn Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val Leu Gly Trp Phe 
305                 310                 315                 320 


Ala Arg Pro Ile Phe Ile Asp Gly Asp Tyr Pro Glu Ser Met Lys Asn 
                325                 330                 335     


Asn Leu Ser Ser Leu Leu Pro Asp Phe Thr Glu Ala Glu Lys Lys Phe 
            340                 345                 350         


Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Ser Phe Gly Pro Thr Leu 
        355                 360                 365             


Ser Phe Gln Leu Leu Asp Pro Gln Met Lys Phe Arg Gln Leu Glu Ser 
    370                 375                 380                 


Pro Ser Leu Arg Gln Leu Leu Ser Trp Ile Ala Leu Glu Tyr Asn His 
385                 390                 395                 400 


Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val Ser Gly Thr Thr 
                405                 410                 415     


Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys Lys Phe Ile Met 
            420                 425                 430         


Glu Thr Leu Lys Ala Ile Arg Leu Asp Gly Val Asp Val Ile Gly Tyr 
        435                 440                 445             


Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His Arg Gly Tyr Asn 
    450                 455                 460                 


Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser Gln Asp Lys Lys 
465                 470                 475                 480 


Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys Leu Ile Glu Lys 
                485                 490                 495     


Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu Glu Gly Thr Phe 
            500                 505                 510         


Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr Ile Gln Val Asp 
        515                 520                 525             


Thr Thr Leu Ser Gln Phe Thr Asp Pro Asn Val Tyr Leu Trp Asp Val 
    530                 535                 540                 


His His Ser Lys Arg Leu Ile Lys Leu Asp Gly Val Val Ser Arg Lys 
545                 550                 555                 560 


Arg Lys Ser Tyr Cys Val Asp Phe Ala Ala Ile Arg Ser Gln Ile Val 
                565                 570                 575     


Leu Leu Gln Glu Thr His Val Thr His Phe His Phe Ser Leu Asp Trp 
            580                 585                 590         


Ala Leu Val Leu Pro Leu Gly Asn Gln Ser Gln Val Asn Arg Thr Val 
        595                 600                 605             


Leu Arg Tyr Tyr Arg Cys Val Val Glu Glu Leu Val Arg Ala Asn Ile 
    610                 615                 620                 


Thr Pro Val Val Ala Leu Trp Gln Pro Ala Ala Pro His Gln Gly Leu 
625                 630                 635                 640 


Pro Gln Pro Leu Ala Gln Gln Gly Ala Trp Glu Asn Pro His Thr Val 
                645                 650                 655     


Leu Ala Phe Val Glu Tyr Ala Arg Leu Cys Phe Met Glu Leu Gly His 
            660                 665                 670         


Arg Ile Lys Phe Trp Ile Thr Met Asn Glu Pro Asn Thr Arg Asn Met 
        675                 680                 685             


Thr Tyr Arg Ala Gly His His Leu Leu Lys Ala His Ala Leu Val Trp 
    690                 695                 700                 


Arg Glu Tyr Asp Gly Lys Phe Arg Pro Ala Gln Lys Gly Lys Val Ser 
705                 710                 715                 720 


Ile Ala Leu Gln Ala Asp Trp Ile Glu Pro Ala Cys Pro Phe Ser Gln 
                725                 730                 735     


Lys Asp Lys Glu Val Ala Glu Arg Val Leu Glu Phe Asp Ile Gly Trp 
            740                 745                 750         


Leu Ala Glu Pro Ile Phe Gly Ser Gly Asp Tyr Pro Arg Val Met Arg 
        755                 760                 765             


Asp Trp Leu Asn Gln Arg Asn Asn Phe Leu Leu Pro Tyr Phe Thr Glu 
    770                 775                 780                 


Glu Glu Arg Gln Leu Val Arg Gly Ser Phe Asp Phe Leu Ala Leu Ser 
785                 790                 795                 800 


His Tyr Thr Thr Ile Leu Val Asp Trp Glu Lys Glu Asp Pro Thr Lys 
                805                 810                 815     


Tyr Asn Asp Tyr Leu Glu Val Gln Glu Met Thr Asp Ile Thr Trp Leu 
            820                 825                 830         


Asn Ser Pro Gly Gln Val Ala Val Val Pro Trp Gly Leu Arg Lys Val 
        835                 840                 845             


Leu Asn Trp Leu Arg Leu Lys Tyr Gly Asp Leu Pro Met Tyr Val Ile 
    850                 855                 860                 


Ala Asn Gly Ile Asp Asp Asp Leu Gln Ala Glu Gln Asp Gln Leu Arg 
865                 870                 875                 880 


Val Tyr Tyr Ile Gln Asn Tyr Val Asn Glu Ala Leu Lys Ala Tyr Met 
                885                 890                 895     


Leu Asp Gly Ile Asn Leu Cys Gly Tyr Phe Ala Tyr Ser Leu Asn Asp 
            900                 905                 910         


Arg Ser Ala Pro Lys Phe Gly Leu Tyr Arg Tyr Ala Ala Asn Gln Phe 
        915                 920                 925             


Glu Pro Lys Pro Ser Met Lys His Tyr Arg Arg Ile Ile Asp Asn Asn 
    930                 935                 940                 


Gly Phe Pro Ser Ser Glu Thr Leu Glu Glu Phe Cys Pro Glu Glu Leu 
945                 950                 955                 960 


Ser Lys Cys Ile Glu Cys Ser Phe Phe His Lys Arg Lys Ser Leu Leu 
                965                 970                 975     


Ala Phe Ile Ala Phe Leu Phe Phe Ala Phe Ile Ile Ser Leu Ser Leu 
            980                 985                 990         


Ile Phe Tyr Tyr Ser Lys Lys Gly  Arg Arg Ser Tyr Lys  
        995                 1000                 1005 


<210>  120
<211>  1013
<212>  PRT
<213>  Capra aegagrus

<400>  120

Met Pro Ala Arg Ala Pro Pro Arg Arg Leu Arg Ala Leu Pro Pro Pro 
1               5                   10                  15      


Pro Pro Pro Leu Trp Leu Leu Leu Leu Ala Leu Gly Gly Arg Pro Leu 
            20                  25                  30          


Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ala Arg 
        35                  40                  45              


Pro Pro Thr Pro Glu Ala Ala Gly Leu Leu His Asp Thr Phe Pro Asp 
    50                  55                  60                  


Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly 
65                  70                  75                  80  


Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His 
                85                  90                  95      


Arg Pro Pro Ala Pro Pro Gly Asp Pro Ser Ala Ala Gly Trp Pro Ser 
            100                 105                 110         


Gly Ala Pro Ser Pro Pro Pro Pro Ala Thr Gly Asp Val Ala Ser Asp 
        115                 120                 125             


Gly Tyr Asn Asn Val Phe Arg Asp Thr Glu Gly Leu Arg Glu Leu Gly 
    130                 135                 140                 


Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn 
145                 150                 155                 160 


Gly Ser Ala Ser Ala Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg 
                165                 170                 175     


Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu 
            180                 185                 190         


Tyr His Trp Asp Leu Pro Gln Leu Leu Gln Asp Ala Tyr Gly Gly Trp 
        195                 200                 205             


Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys 
    210                 215                 220                 


Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn 
225                 230                 235                 240 


Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro 
                245                 250                 255     


Gly Val Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu 
            260                 265                 270         


Leu Leu Ala His Ala Lys Ile Trp His Leu Tyr Asp Thr Ser Phe Arg 
        275                 280                 285             


Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile 
    290                 295                 300                 


Ser Pro Arg Arg Met Thr Glu His Ser Ile Lys Glu Cys Gln Lys Ser 
305                 310                 315                 320 


Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Ile Phe Ile Asp Gly 
                325                 330                 335     


Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Leu Leu Pro Asp 
            340                 345                 350         


Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe 
        355                 360                 365             


Ala Leu Ser Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro Gln 
    370                 375                 380                 


Met Lys Phe Arg Gln Leu Glu Ser Pro Ser Leu Arg Gln Leu Leu Ser 
385                 390                 395                 400 


Trp Ile Asp Leu Glu Tyr Asn His Pro Gln Ile Phe Ile Val Glu Asn 
                405                 410                 415     


Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met 
            420                 425                 430         


Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Arg Leu 
        435                 440                 445             


Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly 
    450                 455                 460                 


Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val 
465                 470                 475                 480 


Asp Phe Leu Ser Gln Asp Lys Lys Leu Leu Pro Lys Ser Ser Ala Leu 
                485                 490                 495     


Phe Tyr Gln Lys Leu Ile Glu Asn Asn Gly Phe Pro Pro Leu Pro Glu 
            500                 505                 510         


Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val 
        515                 520                 525             


Val Asp Asn Cys Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Ile Asp 
    530                 535                 540                 


Pro Asn Val Tyr Leu Trp Asp Val His Arg Ser Lys Arg Leu Ile Lys 
545                 550                 555                 560 


Val Asp Gly Val Leu Thr Lys Thr Arg Lys Ser Tyr Cys Val Asp Phe 
                565                 570                 575     


Ala Ala Ile Arg Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr 
            580                 585                 590         


His Phe His Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn 
        595                 600                 605             


Arg Ser Gln Val Asn Arg Thr Val Leu Gly Phe Tyr Arg Cys Val Ala 
    610                 615                 620                 


Ser Glu Leu Val Arg Ala Asn Ile Thr Pro Val Val Ala Leu Trp Arg 
625                 630                 635                 640 


Pro Ala Ala Pro His Gln Gly Leu Pro Ala Pro Leu Ala Arg His Gly 
                645                 650                 655     


Ala Trp Glu Asn Pro His Thr Ala Leu Ala Phe Ala Glu Tyr Ala Ser 
            660                 665                 670         


Leu Cys Phe Gln Asp Leu Gly Arg His Val Lys Phe Trp Ile Thr Met 
        675                 680                 685             


His Glu Pro Ser Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu 
    690                 695                 700                 


Leu Lys Ala His Ala Leu Ala Trp Arg Thr Tyr Asp Glu Arg Phe Arg 
705                 710                 715                 720 


Arg Ser Gln Lys Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile 
                725                 730                 735     


Glu Pro Ala Cys Pro Phe Ser Pro Glu Asp Arg Glu Val Ala Glu Arg 
            740                 745                 750         


Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser 
        755                 760                 765             


Gly Asp Tyr Pro Arg Val Met Arg Glu Trp Leu Asn Gln Arg Asn Asn 
    770                 775                 780                 


Phe Leu Leu Pro Tyr Phe Thr Asp Glu Glu Lys Lys Leu Ile Arg Gly 
785                 790                 795                 800 


Ser Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp 
                805                 810                 815     


Trp Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Ala Val Gln 
            820                 825                 830         


Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val 
        835                 840                 845             


Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Ala Lys Tyr 
    850                 855                 860                 


Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Asp Pro 
865                 870                 875                 880 


His Thr Ala Gln Asp Asn Leu Arg Val Tyr Tyr Met Gln Asn Tyr Val 
                885                 890                 895     


Asn Glu Ala Leu Lys Ala Tyr Ile Leu Asp Gly Ile Asn Leu Cys Gly 
            900                 905                 910         


Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Lys Phe Gly Leu 
        915                 920                 925             


Tyr Arg Tyr Ala Ala Asn Gln Phe Glu Pro Lys Pro Ser Met Lys His 
    930                 935                 940                 


Tyr Arg Lys Ile Ile Asp Asn Asn Gly Phe Pro Gly Pro Glu Thr Leu 
945                 950                 955                 960 


Gly Arg Phe Cys Pro Glu Glu Phe Thr Leu Cys Thr Glu Cys Ser Phe 
                965                 970                 975     


Phe His Ala Arg Lys Ser Leu Leu Ala Phe Ile Ala Phe Leu Leu Phe 
            980                 985                 990         


Ala Phe Val Ile Ser Leu Ser Leu  Ile Phe Tyr Tyr Ser  Lys Lys Gly 
        995                 1000                 1005             


Arg Arg  Gly Tyr Lys 
    1010             


<210>  121
<211>  4570
<212>  PRT
<213>  Canis familiaris

<400>  121

Ala Thr Gly Gly Cys Cys Ala Cys Cys Thr Gly Cys Ala Thr Thr Thr 
1               5                   10                  15      


Thr Ala Cys Ala Gly Ala Thr Gly Ala Gly Ala Thr Thr Cys Cys Thr 
            20                  25                  30          


Ala Ala Gly Gly Cys Thr Gly Gly Gly Gly Ala Ala Gly Ala Thr Ala 
        35                  40                  45              


Cys Thr Gly Thr Thr Cys Cys Ala Cys Thr Cys Cys Ala Gly Cys Cys 
    50                  55                  60                  


Cys Ala Cys Ala Ala Ala Gly Cys Ala Cys Ala Gly Gly Thr Gly Gly 
65                  70                  75                  80  


Cys Ala Gly Thr Gly Gly Thr Gly Gly Gly Ala Cys Cys Cys Gly Gly 
                85                  90                  95      


Gly Gly Ala Cys Cys Thr Cys Gly Ala Gly Cys Thr Cys Cys Gly Gly 
            100                 105                 110         


Cys Ala Cys Ala Gly Cys Thr Gly Cys Gly Ala Ala Cys Gly Cys Ala 
        115                 120                 125             


Gly Cys Gly Thr Gly Gly Cys Ala Cys Ala Gly Ala Thr Ala Ala Gly 
    130                 135                 140                 


Thr Thr Ala Gly Thr Thr Gly Cys Thr Ala Ala Gly Thr Cys Ala Gly 
145                 150                 155                 160 


Ala Gly Cys Thr Cys Ala Ala Gly Gly Cys Thr Ala Ala Ala Ala Cys 
                165                 170                 175     


Gly Gly Cys Cys Cys Ala Cys Cys Gly Cys Gly Cys Gly Cys Thr Gly 
            180                 185                 190         


Gly Cys Cys Gly Ala Cys Cys Ala Cys Thr Thr Cys Ala Gly Gly Gly 
        195                 200                 205             


Ala Cys Thr Ala Cys Gly Cys Cys Gly Ala Gly Cys Thr Cys Thr Gly 
    210                 215                 220                 


Cys Thr Thr Cys Cys Gly Cys Cys Ala Cys Thr Thr Cys Thr Gly Cys 
225                 230                 235                 240 


Gly Gly Cys Cys Ala Gly Gly Thr Cys Ala Ala Gly Thr Ala Cys Thr 
                245                 250                 255     


Gly Gly Ala Thr Cys Ala Cys Cys Ala Thr Cys Gly Ala Cys Ala Ala 
            260                 265                 270         


Cys Cys Cys Cys Thr Ala Cys Gly Thr Gly Gly Thr Gly Gly Cys Cys 
        275                 280                 285             


Thr Gly Gly Cys Ala Cys Gly Gly Cys Thr Ala Cys Gly Cys Cys Ala 
    290                 295                 300                 


Cys Cys Gly Gly Gly Cys Gly Cys Cys Thr Gly Gly Cys Cys Cys Cys 
305                 310                 315                 320 


Cys Gly Gly Cys Gly Thr Cys Cys Gly Gly Gly Gly Cys Ala Gly Cys 
                325                 330                 335     


Cys Cys Gly Cys Gly Gly Cys Thr Cys Gly Gly Gly Thr Ala Cys Cys 
            340                 345                 350         


Thr Gly Gly Thr Gly Gly Cys Gly Cys Ala Cys Ala Ala Cys Cys Thr 
        355                 360                 365             


Cys Cys Thr Cys Cys Thr Gly Gly Cys Thr Cys Ala Cys Gly Cys Cys 
    370                 375                 380                 


Ala Ala Ala Ala Thr Cys Thr Gly Gly Cys Ala Thr Cys Thr Cys Thr 
385                 390                 395                 400 


Ala Cys Ala Ala Thr Ala Cys Thr Thr Cys Thr Thr Thr Cys Cys Gly 
                405                 410                 415     


Cys Cys Cys Ala Ala Cys Thr Cys Ala Gly Gly Gly Ala Gly Gly Cys 
            420                 425                 430         


Cys Ala Gly Gly Thr Ala Thr Cys Cys Ala Thr Thr Gly Cys Cys Cys 
        435                 440                 445             


Thr Ala Ala Gly Cys Thr Cys Cys Cys Ala Cys Thr Gly Gly Ala Thr 
    450                 455                 460                 


Cys Ala Ala Thr Cys Cys Thr Cys Gly Ala Ala Gly Ala Ala Thr Gly 
465                 470                 475                 480 


Ala Cys Cys Gly Ala Cys Cys Ala Thr Ala Gly Cys Ala Thr Cys Ala 
                485                 490                 495     


Ala Ala Gly Ala Ala Thr Gly Thr Cys Ala Ala Ala Ala Ala Thr Cys 
            500                 505                 510         


Thr Cys Thr Thr Gly Ala Cys Thr Thr Thr Gly Thr Ala Cys Thr Ala 
        515                 520                 525             


Gly Gly Cys Thr Gly Gly Thr Thr Thr Gly Cys Cys Ala Ala Gly Cys 
    530                 535                 540                 


Cys Cys Ala Thr Ala Thr Thr Thr Ala Thr Thr Gly Ala Thr Gly Gly 
545                 550                 555                 560 


Thr Gly Ala Cys Thr Ala Thr Cys Cys Thr Gly Ala Gly Ala Gly Cys 
                565                 570                 575     


Ala Thr Gly Ala Ala Gly Ala Ala Thr Ala Ala Cys Cys Thr Gly Thr 
            580                 585                 590         


Cys Ala Thr Cys Thr Cys Thr Thr Cys Thr Gly Cys Cys Thr Gly Thr 
        595                 600                 605             


Thr Thr Thr Thr Ala Cys Thr Gly Ala Ala Thr Cys Thr Gly Ala Gly 
    610                 615                 620                 


Ala Ala Ala Ala Ala Gly Thr Thr Cys Ala Thr Cys Ala Ala Gly Gly 
625                 630                 635                 640 


Gly Ala Ala Cys Ala Gly Cys Thr Gly Ala Cys Thr Thr Thr Thr Thr 
                645                 650                 655     


Thr Gly Cys Thr Cys Thr Thr Thr Cys Thr Thr Thr Thr Gly Gly Ala 
            660                 665                 670         


Cys Cys Ala Ala Cys Thr Thr Thr Gly Ala Gly Thr Thr Thr Thr Cys 
        675                 680                 685             


Ala Ala Cys Thr Cys Thr Thr Gly Gly Ala Cys Cys Cys Thr Cys Ala 
    690                 695                 700                 


Thr Ala Thr Gly Ala Ala Gly Thr Thr Cys Cys Ala Cys Cys Ala Ala 
705                 710                 715                 720 


Thr Thr Ala Gly Ala Ala Thr Cys Thr Cys Cys Cys Ala Gly Cys Cys 
                725                 730                 735     


Thr Gly Ala Gly Gly Cys Ala Ala Cys Thr Cys Cys Thr Thr Thr Cys 
            740                 745                 750         


Thr Thr Gly Gly Ala Thr Thr Gly Ala Cys Cys Thr Thr Gly Ala Ala 
        755                 760                 765             


Thr Ala Thr Ala Ala Cys Cys Ala Cys Cys Cys Thr Cys Ala Ala Ala 
    770                 775                 780                 


Thr Ala Thr Thr Thr Ala Thr Thr Gly Thr Gly Gly Ala Ala Ala Ala 
785                 790                 795                 800 


Thr Gly Gly Cys Thr Gly Gly Thr Thr Thr Gly Thr Cys Thr Cys Ala 
                805                 810                 815     


Gly Gly Gly Ala Cys Cys Ala Cys Cys Ala Ala Gly Ala Gly Ala Gly 
            820                 825                 830         


Ala Thr Gly Ala Thr Gly Cys Cys Ala Ala Ala Thr Ala Thr Ala Thr 
        835                 840                 845             


Gly Thr Ala Thr Thr Ala Cys Cys Thr Cys Ala Ala Ala Ala Ala Ala 
    850                 855                 860                 


Thr Thr Cys Ala Thr Ala Ala Thr Gly Gly Ala Ala Ala Cys Cys Thr 
865                 870                 875                 880 


Thr Ala Ala Ala Ala Gly Cys Cys Ala Thr Cys Ala Gly Gly Cys Thr 
                885                 890                 895     


Gly Gly Ala Thr Gly Gly Gly Gly Thr Gly Gly Ala Thr Gly Thr Cys 
            900                 905                 910         


Ala Thr Ala Gly Gly Ala Thr Ala Cys Ala Cys Ala Gly Cys Gly Thr 
        915                 920                 925             


Gly Gly Thr Cys Cys Cys Thr Thr Ala Thr Gly Gly Ala Thr Gly Gly 
    930                 935                 940                 


Cys Thr Thr Cys Gly Ala Gly Thr Gly Gly Cys Ala Cys Ala Gly Ala 
945                 950                 955                 960 


Gly Gly Cys Thr Ala Cys Ala Gly Cys Ala Thr Cys Ala Gly Ala Cys 
                965                 970                 975     


Gly Thr Gly Gly Ala Cys Thr Cys Thr Thr Cys Thr Ala Cys Gly Thr 
            980                 985                 990         


Gly Gly Ala Cys Thr Thr Thr Cys  Thr Ala Ala Gly Cys  Cys Ala Gly 
        995                 1000                 1005             


Gly Ala  Thr Ala Ala Gly Ala  Ala Ala Cys Thr Gly  Thr Thr Gly 
    1010                 1015                 1020             


Cys Cys  Ala Ala Ala Gly Thr  Cys Thr Thr Cys Ala  Gly Cys Cys 
    1025                 1030                 1035             


Thr Thr  Gly Thr Thr Cys Thr  Ala Cys Cys Ala Ala  Ala Ala Gly 
    1040                 1045                 1050             


Cys Thr  Gly Ala Thr Ala Gly  Ala Gly Ala Ala Ala  Ala Ala Thr 
    1055                 1060                 1065             


Gly Gly  Cys Thr Thr Cys Cys  Cys Thr Cys Cys Thr  Thr Thr Ala 
    1070                 1075                 1080             


Cys Cys  Thr Gly Ala Ala Ala  Ala Thr Cys Ala Gly  Cys Cys Cys 
    1085                 1090                 1095             


Cys Thr  Ala Gly Ala Ala Gly  Gly Gly Ala Cys Ala  Thr Thr Thr 
    1100                 1105                 1110             


Cys Cys  Cys Thr Gly Thr Gly  Ala Cys Thr Thr Thr  Gly Cys Thr 
    1115                 1120                 1125             


Thr Gly  Gly Gly Gly Ala Ala  Thr Thr Gly Thr Thr  Gly Ala Cys 
    1130                 1135                 1140             


Ala Ala  Cys Thr Ala Cys Ala  Thr Thr Cys Ala Ala  Gly Thr Gly 
    1145                 1150                 1155             


Gly Ala  Cys Ala Cys Cys Ala  Cys Thr Cys Thr Gly  Thr Cys Thr 
    1160                 1165                 1170             


Cys Ala  Gly Thr Thr Thr Ala  Cys Cys Gly Ala Cys  Cys Cys Gly 
    1175                 1180                 1185             


Ala Ala  Cys Gly Thr Thr Thr  Ala Cys Cys Thr Gly  Thr Gly Gly 
    1190                 1195                 1200             


Gly Ala  Cys Gly Thr Cys Cys  Ala Thr Cys Ala Cys  Ala Gly Cys 
    1205                 1210                 1215             


Ala Ala  Gly Ala Gly Gly Cys  Thr Gly Ala Thr Thr  Ala Ala Gly 
    1220                 1225                 1230             


Gly Thr  Gly Gly Ala Cys Gly  Gly Gly Cys Thr Gly  Cys Gly Gly 
    1235                 1240                 1245             


Gly Cys  Cys Ala Ala Gly Ala  Ala Gly Ala Gly Gly  Ala Ala Gly 
    1250                 1255                 1260             


Cys Cys  Cys Thr Ala Cys Thr  Gly Cys Gly Thr Gly  Gly Ala Cys 
    1265                 1270                 1275             


Thr Thr  Thr Gly Cys Cys Gly  Cys Cys Ala Thr Cys  Gly Gly Gly 
    1280                 1285                 1290             


Cys Cys  Cys Cys Ala Gly Gly  Thr Gly Gly Cys Cys  Cys Thr Gly 
    1295                 1300                 1305             


Cys Thr  Gly Cys Ala Gly Gly  Ala Gly Ala Thr Gly  Cys Ala Cys 
    1310                 1315                 1320             


Gly Thr  Cys Thr Cys Gly Cys  Ala Thr Thr Thr Thr  Cys Ala Cys 
    1325                 1330                 1335             


Thr Thr  Cys Thr Cys Gly Cys  Thr Gly Gly Ala Cys  Thr Gly Gly 
    1340                 1345                 1350             


Gly Cys  Cys Cys Thr Gly Cys  Thr Cys Cys Thr Gly  Cys Cys Gly 
    1355                 1360                 1365             


Cys Thr  Gly Gly Gly Cys Ala  Ala Cys Cys Ala Gly  Thr Cys Cys 
    1370                 1375                 1380             


Cys Gly  Gly Gly Thr Gly Ala  Ala Cys Cys Ala Cys  Gly Cys Gly 
    1385                 1390                 1395             


Gly Cys  Cys Cys Thr Gly Cys  Ala Cys Thr Ala Cys  Thr Ala Cys 
    1400                 1405                 1410             


Gly Gly  Cys Thr Gly Cys Gly  Thr Gly Gly Cys Cys  Ala Gly Cys 
    1415                 1420                 1425             


Gly Ala  Gly Cys Thr Cys Cys  Thr Gly Cys Gly Cys  Gly Cys Cys 
    1430                 1435                 1440             


Ala Ala  Cys Ala Thr Cys Ala  Cys Cys Cys Cys Gly  Gly Thr Gly 
    1445                 1450                 1455             


Gly Thr  Gly Gly Cys Gly Cys  Thr Cys Thr Gly Gly  Cys Gly Cys 
    1460                 1465                 1470             


Cys Cys  Cys Gly Cys Cys Gly  Cys Cys Gly Cys Gly  Cys Ala Cys 
    1475                 1480                 1485             


Cys Ala  Gly Gly Gly Cys Cys  Thr Gly Cys Cys Gly  Gly Gly Gly 
    1490                 1495                 1500             


Cys Cys  Gly Cys Thr Gly Gly  Cys Cys Cys Ala Gly  Cys Gly Cys 
    1505                 1510                 1515             


Gly Gly  Cys Gly Cys Cys Thr  Gly Gly Gly Ala Gly  Ala Ala Cys 
    1520                 1525                 1530             


Cys Cys  Gly Cys Gly Cys Ala  Cys Cys Gly Cys Cys  Cys Thr Gly 
    1535                 1540                 1545             


Gly Cys  Gly Thr Thr Cys Gly  Cys Cys Gly Ala Gly  Thr Ala Cys 
    1550                 1555                 1560             


Gly Cys  Gly Cys Gly Cys Cys  Thr Gly Thr Gly Cys  Thr Thr Cys 
    1565                 1570                 1575             


Cys Gly  Cys Gly Cys Cys Cys  Thr Gly Gly Gly Cys  Cys Gly Cys 
    1580                 1585                 1590             


Cys Ala  Cys Gly Thr Cys Ala  Ala Gly Gly Thr Gly  Thr Gly Gly 
    1595                 1600                 1605             


Ala Thr  Cys Ala Cys Gly Cys  Thr Gly Cys Gly Cys  Gly Ala Gly 
    1610                 1615                 1620             


Cys Cys  Gly Cys Cys Cys Ala  Cys Gly Cys Gly Gly  Ala Ala Cys 
    1625                 1630                 1635             


Cys Thr  Gly Ala Cys Gly Cys  Thr Cys Cys Gly Cys  Gly Cys Cys 
    1640                 1645                 1650             


Gly Gly  Gly Cys Ala Cys Ala  Ala Cys Cys Thr Gly  Cys Thr Gly 
    1655                 1660                 1665             


Cys Gly  Gly Gly Cys Gly Cys  Ala Cys Gly Cys Gly  Cys Thr Gly 
    1670                 1675                 1680             


Gly Cys  Cys Thr Gly Gly Cys  Gly Cys Gly Thr Gly  Thr Ala Cys 
    1685                 1690                 1695             


Gly Ala  Cys Gly Ala Gly Cys  Ala Gly Thr Thr Cys  Cys Gly Gly 
    1700                 1705                 1710             


Gly Gly  Cys Thr Cys Gly Cys  Ala Gly Cys Ala Gly  Gly Gly Gly 
    1715                 1720                 1725             


Ala Ala  Gly Gly Thr Gly Thr  Cys Cys Ala Thr Cys  Gly Cys Cys 
    1730                 1735                 1740             


Cys Thr  Gly Cys Ala Gly Gly  Cys Cys Gly Ala Cys  Thr Gly Gly 
    1745                 1750                 1755             


Gly Thr  Gly Gly Ala Gly Cys  Cys Cys Gly Cys Cys  Thr Gly Cys 
    1760                 1765                 1770             


Cys Cys  Cys Thr Cys Cys Thr  Cys Cys Cys Ala Gly  Ala Ala Gly 
    1775                 1780                 1785             


Gly Ala  Cys Cys Gly Cys Gly  Ala Ala Gly Thr Gly  Gly Cys Cys 
    1790                 1795                 1800             


Gly Ala  Gly Ala Gly Gly Gly  Thr Thr Cys Thr Gly  Gly Ala Gly 
    1805                 1810                 1815             


Thr Thr  Cys Gly Ala Cys Gly  Thr Cys Gly Gly Cys  Thr Gly Gly 
    1820                 1825                 1830             


Cys Thr  Gly Gly Cys Cys Gly  Ala Gly Cys Cys Cys  Ala Thr Cys 
    1835                 1840                 1845             


Thr Thr  Cys Gly Gly Cys Thr  Cys Cys Gly Gly Gly  Gly Ala Cys 
    1850                 1855                 1860             


Thr Ala  Cys Cys Cys Gly Cys  Gly Gly Cys Thr Gly  Ala Thr Gly 
    1865                 1870                 1875             


Cys Gly  Cys Gly Ala Cys Thr  Gly Gly Cys Thr Cys  Ala Cys Cys 
    1880                 1885                 1890             


Cys Gly  Gly Ala Gly Ala Gly  Ala Cys Cys Ala Thr  Thr Cys Cys 
    1895                 1900                 1905             


Cys Thr  Cys Cys Thr Gly Cys  Cys Cys Thr Ala Thr  Thr Thr Cys 
    1910                 1915                 1920             


Ala Cys  Thr Gly Ala Cys Gly  Ala Ala Gly Ala Gly  Ala Ala Gly 
    1925                 1930                 1935             


Ala Gly  Gly Cys Thr Ala Ala  Thr Cys Cys Gly Gly  Gly Gly Thr 
    1940                 1945                 1950             


Thr Cys  Cys Thr Thr Thr Gly  Ala Cys Thr Thr Cys  Cys Thr Gly 
    1955                 1960                 1965             


Gly Cys  Cys Thr Thr Gly Ala  Gly Cys Cys Ala Thr  Thr Ala Cys 
    1970                 1975                 1980             


Ala Cys  Cys Ala Cys Cys Ala  Thr Cys Cys Thr Cys  Gly Thr Gly 
    1985                 1990                 1995             


Gly Ala  Cys Thr Gly Gly Gly  Ala Ala Ala Ala Gly  Gly Ala Ala 
    2000                 2005                 2010             


Gly Ala  Cys Cys Cys Ala Gly  Thr Cys Ala Ala Ala  Thr Ala Cys 
    2015                 2020                 2025             


Ala Ala  Thr Gly Ala Thr Thr  Ala Cys Cys Thr Gly  Gly Ala Ala 
    2030                 2035                 2040             


Gly Thr  Gly Cys Ala Gly Gly  Ala Gly Ala Thr Gly  Ala Cys Cys 
    2045                 2050                 2055             


Gly Ala  Cys Ala Thr Cys Ala  Cys Cys Thr Gly Gly  Cys Thr Cys 
    2060                 2065                 2070             


Ala Ala  Cys Thr Cys Cys Cys  Cys Cys Ala Gly Thr  Cys Ala Gly 
    2075                 2080                 2085             


Gly Thr  Gly Gly Cys Cys Gly  Thr Ala Gly Thr Gly  Cys Cys Cys 
    2090                 2095                 2100             


Thr Gly  Gly Gly Gly Cys Cys  Thr Gly Cys Gly Cys  Ala Ala Ala 
    2105                 2110                 2115             


Gly Thr  Gly Cys Thr Cys Ala  Ala Cys Thr Gly Gly  Cys Thr Cys 
    2120                 2125                 2130             


Ala Ala  Gly Thr Thr Cys Ala  Ala Gly Thr Ala Cys  Gly Gly Ala 
    2135                 2140                 2145             


Gly Ala  Cys Cys Thr Cys Cys  Cys Cys Ala Thr Gly  Thr Ala Thr 
    2150                 2155                 2160             


Ala Thr  Cys Gly Thr Ala Thr  Cys Cys Ala Ala Cys  Gly Gly Cys 
    2165                 2170                 2175             


Ala Thr  Ala Gly Ala Thr Gly  Ala Cys Gly Ala Thr  Cys Cys Gly 
    2180                 2185                 2190             


Cys Gly  Gly Gly Cys Ala Gly  Cys Cys Cys Ala Gly  Gly Ala Cys 
    2195                 2200                 2205             


Thr Cys  Gly Thr Thr Gly Ala  Gly Gly Gly Thr Gly  Thr Ala Thr 
    2210                 2215                 2220             


Thr Ala  Cys Ala Thr Gly Cys  Ala Gly Ala Ala Cys  Thr Ala Thr 
    2225                 2230                 2235             


Gly Thr  Ala Ala Ala Thr Gly  Ala Ala Gly Cys Thr  Cys Thr Gly 
    2240                 2245                 2250             


Ala Ala  Ala Gly Cys Cys Thr  Ala Cys Gly Thr Ala  Thr Thr Gly 
    2255                 2260                 2265             


Gly Ala  Thr Gly Gly Thr Ala  Thr Cys Ala Ala Thr  Cys Thr Thr 
    2270                 2275                 2280             


Thr Gly  Thr Gly Gly Ala Thr  Ala Cys Thr Thr Thr  Gly Cys Cys 
    2285                 2290                 2295             


Thr Ala  Cys Thr Cys Ala Thr  Thr Thr Ala Ala Thr  Gly Ala Thr 
    2300                 2305                 2310             


Cys Gly  Cys Ala Cys Ala Gly  Cys Thr Cys Cys Gly  Ala Ala Gly 
    2315                 2320                 2325             


Thr Thr  Thr Gly Gly Cys Cys  Thr Cys Thr Ala Thr  Cys Ala Thr 
    2330                 2335                 2340             


Thr Ala  Thr Gly Cys Thr Gly  Cys Ala Ala Ala Cys  Cys Ala Gly 
    2345                 2350                 2355             


Thr Thr  Thr Gly Ala Gly Cys  Cys Cys Ala Ala Ala  Cys Cys Gly 
    2360                 2365                 2370             


Thr Cys  Gly Gly Thr Gly Ala  Ala Gly Cys Ala Thr  Thr Ala Cys 
    2375                 2380                 2385             


Ala Gly  Gly Ala Ala Ala Ala  Thr Thr Ala Thr Thr  Gly Ala Cys 
    2390                 2395                 2400             


Ala Ala  Cys Ala Ala Thr Gly  Gly Cys Thr Thr Cys  Cys Cys Ala 
    2405                 2410                 2415             


Gly Gly  Cys Cys Cys Thr Gly  Ala Ala Ala Cys Thr  Thr Thr Gly 
    2420                 2425                 2430             


Gly Gly  Gly Cys Gly Gly Thr  Thr Thr Thr Gly Thr  Cys Cys Ala 
    2435                 2440                 2445             


Gly Ala  Gly Gly Ala Ala Thr  Thr Cys Ala Cys Cys  Cys Thr Gly 
    2450                 2455                 2460             


Thr Gly  Cys Ala Cys Cys Gly  Ala Ala Thr Gly Cys  Ala Gly Cys 
    2465                 2470                 2475             


Thr Thr  Thr Thr Thr Thr Cys  Ala Cys Ala Cys Cys  Cys Gly Ala 
    2480                 2485                 2490             


Ala Ala  Gly Thr Cys Thr Thr  Thr Ala Cys Thr Gly  Gly Cys Thr 
    2495                 2500                 2505             


Thr Thr  Cys Ala Thr Ala Gly  Cys Thr Thr Thr Cys  Cys Thr Ala 
    2510                 2515                 2520             


Cys Thr  Thr Thr Thr Thr Gly  Cys Thr Thr Thr Thr  Ala Thr Thr 
    2525                 2530                 2535             


Ala Thr  Thr Thr Cys Thr Cys  Thr Thr Thr Cys Thr  Cys Thr Gly 
    2540                 2545                 2550             


Ala Thr  Thr Thr Thr Cys Thr  Ala Cys Thr Ala Cys  Thr Cys Thr 
    2555                 2560                 2565             


Ala Gly  Gly Ala Ala Ala Gly  Gly Cys Ala Gly Ala  Ala Gly Ala 
    2570                 2575                 2580             


Ala Gly  Thr Thr Ala Thr Ala  Ala Ala Thr Ala Gly  Thr Cys Cys 
    2585                 2590                 2595             


Thr Gly  Ala Ala Cys Ala Thr  Thr Thr Thr Cys Cys  Thr Ala Thr 
    2600                 2605                 2610             


Thr Cys  Ala Thr Cys Thr Ala  Thr Thr Thr Thr Gly  Ala Ala Ala 
    2615                 2620                 2625             


Thr Ala  Ala Thr Thr Ala Thr  Gly Cys Ala Cys Ala  Thr Ala Cys 
    2630                 2635                 2640             


Ala Thr  Cys Ala Gly Cys Thr  Gly Thr Thr Ala Ala  Cys Cys Ala 
    2645                 2650                 2655             


Thr Thr  Thr Gly Cys Ala Cys  Thr Thr Cys Thr Cys  Ala Gly Thr 
    2660                 2665                 2670             


Gly Thr  Thr Gly Thr Gly Ala  Ala Ala Cys Thr Ala  Thr Ala Gly 
    2675                 2680                 2685             


Gly Thr  Thr Thr Cys Gly Thr  Thr Ala Thr Thr Cys  Cys Gly Gly 
    2690                 2695                 2700             


Cys Thr  Thr Cys Thr Ala Gly  Ala Ala Gly Ala Ala  Ala Ala Ala 
    2705                 2710                 2715             


Thr Thr  Thr Thr Thr Gly Thr  Gly Gly Cys Ala Thr  Ala Thr Gly 
    2720                 2725                 2730             


Ala Cys  Ala Gly Ala Cys Gly  Thr Thr Thr Gly Thr  Ala Ala Ala 
    2735                 2740                 2745             


Thr Gly  Ala Gly Cys Ala Thr  Ala Gly Cys Thr Gly  Ala Thr Thr 
    2750                 2755                 2760             


Gly Thr  Ala Ala Ala Ala Thr  Ala Thr Thr Gly Gly  Ala Thr Ala 
    2765                 2770                 2775             


Ala Thr  Gly Thr Gly Ala Ala  Thr Ala Gly Thr Gly  Cys Cys Thr 
    2780                 2785                 2790             


Gly Gly  Ala Thr Thr Thr Gly  Thr Thr Cys Thr Thr  Thr Thr Thr 
    2795                 2800                 2805             


Thr Thr  Gly Ala Ala Gly Gly  Gly Thr Ala Ala Thr  Cys Ala Ala 
    2810                 2815                 2820             


Ala Gly  Ala Cys Thr Gly Thr  Cys Ala Gly Gly Gly  Gly Cys Cys 
    2825                 2830                 2835             


Ala Thr  Cys Ala Thr Thr Cys  Cys Thr Gly Thr Ala  Ala Cys Ala 
    2840                 2845                 2850             


Cys Ala  Cys Ala Cys Thr Gly  Thr Ala Ala Cys Ala  Ala Ala Thr 
    2855                 2860                 2865             


Gly Thr  Ala Thr Gly Gly Gly  Ala Ala Gly Thr Gly  Gly Gly Gly 
    2870                 2875                 2880             


Gly Thr  Cys Ala Cys Thr Cys  Thr Gly Cys Ala Ala  Cys Ala Thr 
    2885                 2890                 2895             


Thr Thr  Thr Thr Ala Cys Ala  Gly Ala Ala Ala Thr  Thr Gly Ala 
    2900                 2905                 2910             


Ala Thr  Gly Gly Thr Gly Cys  Cys Cys Ala Thr Thr  Cys Ala Ala 
    2915                 2920                 2925             


Thr Thr  Ala Gly Thr Gly Cys  Cys Cys Ala Thr Thr  Cys Thr Thr 
    2930                 2935                 2940             


Ala Ala  Ala Thr Gly Thr Ala  Ala Thr Gly Thr Thr  Thr Ala Thr 
    2945                 2950                 2955             


Cys Thr  Cys Gly Ala Ala Gly  Thr Ala Ala Thr Ala  Ala Thr Thr 
    2960                 2965                 2970             


Gly Cys  Ala Gly Ala Thr Gly  Thr Thr Gly Gly Ala  Ala Thr Ala 
    2975                 2980                 2985             


Ala Ala  Ala Ala Gly Thr Thr  Ala Ala Ala Ala Gly  Gly Thr Cys 
    2990                 2995                 3000             


Cys Cys  Ala Ala Gly Cys Ala  Ala Cys Cys Ala Thr  Cys Thr Cys 
    3005                 3010                 3015             


Thr Ala  Ala Ala Cys Cys Gly  Cys Cys Ala Thr Gly  Ala Thr Ala 
    3020                 3025                 3030             


Thr Gly  Cys Cys Thr Ala Ala  Gly Gly Gly Thr Thr  Cys Gly Cys 
    3035                 3040                 3045             


Thr Gly  Thr Thr Gly Ala Ala  Cys Cys Ala Ala Gly  Thr Thr Thr 
    3050                 3055                 3060             


Cys Cys  Cys Cys Thr Gly Ala  Ala Ala Ala Ala Cys  Ala Ala Ala 
    3065                 3070                 3075             


Gly Gly  Gly Gly Thr Ala Gly  Ala Ala Thr Ala Thr  Ala Gly Gly 
    3080                 3085                 3090             


Ala Gly  Ala Ala Gly Thr Gly  Ala Cys Ala Ala Gly  Gly Gly Gly 
    3095                 3100                 3105             


Cys Cys  Ala Ala Gly Gly Gly  Gly Gly Gly Cys Ala  Gly Cys Ala 
    3110                 3115                 3120             


Ala Cys  Gly Thr Thr Cys Cys  Thr Thr Thr Thr Ala  Ala Ala Ala 
    3125                 3130                 3135             


Gly Cys  Ala Gly Thr Gly Thr  Thr Thr Cys Thr Ala  Gly Cys Ala 
    3140                 3145                 3150             


Ala Ala  Thr Gly Cys Thr Gly  Cys Thr Ala Ala Thr  Ala Thr Thr 
    3155                 3160                 3165             


Ala Gly  Thr Thr Thr Cys Cys  Gly Thr Gly Thr Cys  Thr Gly Gly 
    3170                 3175                 3180             


Thr Thr  Ala Ala Thr Gly Ala  Thr Ala Thr Gly Thr  Thr Thr Ala 
    3185                 3190                 3195             


Gly Cys  Ala Gly Ala Gly Cys  Ala Gly Ala Thr Thr  Ala Thr Ala 
    3200                 3205                 3210             


Gly Ala  Ala Cys Thr Thr Cys  Ala Thr Cys Gly Thr  Thr Thr Gly 
    3215                 3220                 3225             


Thr Gly  Ala Cys Thr Thr Thr  Thr Gly Ala Gly Gly  Thr Cys Thr 
    3230                 3235                 3240             


Cys Cys  Ala Gly Gly Cys Cys  Cys Gly Gly Gly Gly  Gly Thr Cys 
    3245                 3250                 3255             


Cys Thr  Thr Gly Ala Gly Gly  Ala Cys Thr Thr Thr  Gly Thr Gly 
    3260                 3265                 3270             


Thr Thr  Ala Cys Thr Gly Gly  Gly Gly Cys Cys Thr  Thr Ala Cys 
    3275                 3280                 3285             


Cys Ala  Ala Gly Gly Gly Cys  Cys Thr Gly Cys Gly  Cys Ala Ala 
    3290                 3295                 3300             


Ala Ala  Ala Gly Gly Ala Cys  Thr Cys Thr Thr Ala  Ala Thr Gly 
    3305                 3310                 3315             


Thr Thr  Thr Gly Thr Ala Gly  Ala Ala Ala Ala Ala  Thr Ala Ala 
    3320                 3325                 3330             


Gly Thr  Ala Thr Gly Ala Ala  Thr Cys Gly Thr Gly  Ala Gly Ala 
    3335                 3340                 3345             


Thr Gly  Thr Thr Gly Gly Cys  Cys Thr Cys Thr Thr  Cys Ala Gly 
    3350                 3355                 3360             


Gly Ala  Ala Gly Cys Ala Thr  Gly Ala Ala Cys Thr  Gly Ala Thr 
    3365                 3370                 3375             


Cys Thr  Thr Gly Ala Ala Ala  Thr Gly Cys Ala Thr  Thr Gly Thr 
    3380                 3385                 3390             


Ala Cys  Thr Gly Cys Gly Thr  Gly Gly Cys Thr Cys  Thr Ala Gly 
    3395                 3400                 3405             


Gly Gly  Gly Gly Ala Gly Gly  Ala Ala Ala Gly Gly  Ala Gly Gly 
    3410                 3415                 3420             


Ala Ala  Ala Ala Ala Gly Thr  Ala Cys Thr Thr Ala  Thr Thr Ala 
    3425                 3430                 3435             


Thr Gly  Ala Gly Cys Ala Ala  Cys Gly Gly Thr Ala  Thr Gly Ala 
    3440                 3445                 3450             


Thr Thr  Ala Ala Thr Thr Thr  Gly Ala Thr Thr Ala  Thr Ala Ala 
    3455                 3460                 3465             


Ala Cys  Thr Cys Thr Thr Cys  Gly Ala Thr Thr Thr  Thr Ala Gly 
    3470                 3475                 3480             


Ala Gly  Cys Ala Cys Thr Cys  Cys Ala Thr Gly Cys  Ala Ala Thr 
    3485                 3490                 3495             


Gly Ala  Ala Thr Gly Ala Thr  Gly Thr Gly Ala Cys  Cys Thr Thr 
    3500                 3505                 3510             


Thr Cys  Cys Thr Gly Ala Gly  Cys Ala Ala Gly Thr  Gly Ala Gly 
    3515                 3520                 3525             


Ala Ala  Cys Gly Ala Ala Ala  Thr Ala Ala Thr Ala  Ala Cys Thr 
    3530                 3535                 3540             


Cys Ala  Thr Cys Cys Gly Cys  Thr Gly Ala Cys Gly  Ala Gly Thr 
    3545                 3550                 3555             


Gly Ala  Cys Thr Thr Cys Gly  Cys Thr Thr Gly Cys  Thr Gly Thr 
    3560                 3565                 3570             


Thr Cys  Thr Thr Cys Ala Gly  Ala Ala Thr Gly Thr  Gly Thr Cys 
    3575                 3580                 3585             


Ala Thr  Gly Ala Thr Thr Thr  Cys Thr Thr Thr Gly  Ala Ala Thr 
    3590                 3595                 3600             


Thr Gly  Ala Gly Gly Thr Thr  Thr Thr Thr Ala Ala  Ala Ala Thr 
    3605                 3610                 3615             


Thr Cys  Thr Thr Ala Gly Thr  Ala Gly Gly Cys Thr  Cys Cys Ala 
    3620                 3625                 3630             


Ala Ala  Gly Cys Ala Thr Thr  Thr Gly Gly Thr Cys  Thr Gly Ala 
    3635                 3640                 3645             


Thr Ala  Ala Cys Ala Cys Thr  Gly Gly Gly Ala Gly  Ala Thr Thr 
    3650                 3655                 3660             


Thr Gly  Thr Thr Cys Cys Thr  Ala Thr Gly Ala Thr  Thr Gly Cys 
    3665                 3670                 3675             


Thr Gly  Ala Gly Gly Thr Thr  Thr Ala Thr Thr Thr  Thr Ala Cys 
    3680                 3685                 3690             


Ala Thr  Thr Gly Thr Thr Gly  Cys Thr Gly Cys Ala  Ala Cys Thr 
    3695                 3700                 3705             


Thr Cys  Thr Gly Thr Gly Gly  Ala Ala Cys Thr Ala  Gly Cys Thr 
    3710                 3715                 3720             


Thr Thr  Gly Ala Ala Cys Thr  Ala Gly Thr Thr Thr  Thr Gly Cys 
    3725                 3730                 3735             


Thr Thr  Thr Gly Ala Ala Cys  Thr Thr Thr Cys Ala  Cys Ala Gly 
    3740                 3745                 3750             


Thr Gly  Ala Ala Ala Cys Ala  Gly Gly Cys Thr Ala  Cys Thr Gly 
    3755                 3760                 3765             


Ala Thr  Thr Thr Cys Thr Ala  Gly Ala Ala Ala Gly  Gly Gly Cys 
    3770                 3775                 3780             


Thr Ala  Ala Thr Gly Ala Gly  Gly Thr Cys Thr Thr  Ala Thr Cys 
    3785                 3790                 3795             


Cys Thr  Thr Gly Ala Ala Ala  Gly Cys Cys Cys Cys  Thr Thr Ala 
    3800                 3805                 3810             


Ala Gly  Thr Thr Thr Thr Gly  Ala Thr Gly Ala Thr  Thr Thr Thr 
    3815                 3820                 3825             


Cys Ala  Gly Ala Cys Ala Gly  Gly Gly Gly Thr Cys  Thr Thr Thr 
    3830                 3835                 3840             


Cys Thr  Gly Thr Thr Ala Cys  Ala Cys Thr Gly Gly  Ala Gly Thr 
    3845                 3850                 3855             


Thr Gly  Cys Gly Gly Ala Thr  Gly Ala Thr Cys Ala  Thr Gly Thr 
    3860                 3865                 3870             


Thr Ala  Thr Thr Thr Cys Thr  Thr Thr Thr Cys Thr  Ala Gly Ala 
    3875                 3880                 3885             


Thr Ala  Ala Gly Cys Cys Ala  Ala Thr Ala Thr Cys  Ala Thr Ala 
    3890                 3895                 3900             


Thr Cys  Ala Gly Gly Cys Ala  Ala Gly Gly Thr Ala  Ala Ala Cys 
    3905                 3910                 3915             


Cys Ala  Cys Thr Ala Thr Cys  Ala Thr Ala Thr Cys  Thr Ala Gly 
    3920                 3925                 3930             


Cys Ala  Thr Cys Gly Cys Thr  Ala Ala Thr Cys Thr  Thr Gly Cys 
    3935                 3940                 3945             


Thr Gly  Ala Cys Ala Cys Ala  Gly Gly Gly Thr Gly  Ala Thr Ala 
    3950                 3955                 3960             


Gly Thr  Gly Thr Gly Cys Ala  Ala Ala Ala Ala Ala  Ala Thr Thr 
    3965                 3970                 3975             


Gly Cys  Thr Gly Thr Ala Cys  Thr Gly Thr Ala Thr  Thr Ala Thr 
    3980                 3985                 3990             


Gly Thr  Ala Thr Cys Ala Thr  Cys Thr Thr Cys Ala  Gly Ala Gly 
    3995                 4000                 4005             


Gly Thr  Gly Gly Thr Ala Gly  Gly Ala Thr Thr Thr  Thr Thr Thr 
    4010                 4015                 4020             


Thr Thr  Cys Cys Ala Thr Gly  Ala Ala Ala Gly Ala  Thr Gly Ala 
    4025                 4030                 4035             


Gly Cys  Thr Thr Thr Thr Gly  Thr Thr Gly Gly Thr  Ala Ala Thr 
    4040                 4045                 4050             


Cys Thr  Thr Thr Thr Ala Ala  Ala Ala Ala Thr Thr  Gly Gly Ala 
    4055                 4060                 4065             


Cys Thr  Thr Gly Gly Thr Ala  Thr Thr Ala Ala Ala  Ala Thr Thr 
    4070                 4075                 4080             


Ala Gly  Ala Ala Ala Cys Thr  Ala Gly Ala Thr Ala  Thr Ala Ala 
    4085                 4090                 4095             


Thr Ala  Gly Thr Thr Thr Cys  Thr Thr Thr Thr Ala  Thr Gly Thr 
    4100                 4105                 4110             


Ala Thr  Ala Thr Ala Thr Thr  Thr Thr Thr Thr Cys  Cys Gly Ala 
    4115                 4120                 4125             


Thr Thr  Cys Thr Thr Ala Gly  Ala Gly Thr Ala Ala  Thr Thr Thr 
    4130                 4135                 4140             


Ala Thr  Gly Thr Thr Cys Ala  Thr Thr Gly Thr Ala  Ala Ala Ala 
    4145                 4150                 4155             


Ala Ala  Thr Thr Gly Ala Ala  Ala Ala Ala Cys Ala  Cys Ala Gly 
    4160                 4165                 4170             


Ala Ala  Ala Cys Thr Ala Thr  Ala Thr Gly Thr Ala  Ala Ala Gly 
    4175                 4180                 4185             


Ala Gly  Ala Ala Ala Ala Ala  Thr Gly Ala Cys Cys  Thr Ala Thr 
    4190                 4195                 4200             


Ala Ala  Gly Cys Thr Cys Ala  Cys Thr Ala Cys Cys  Ala Ala Ala 
    4205                 4210                 4215             


Gly Thr  Gly Gly Cys Cys Ala  Cys Thr Ala Thr Thr  Ala Ala Cys 
    4220                 4225                 4230             


Ala Thr  Ala Gly Cys Cys Gly  Ala Thr Gly Thr Ala  Thr Thr Thr 
    4235                 4240                 4245             


Thr Ala  Thr Thr Thr Thr Gly  Cys Ala Thr Gly Gly  Ala Gly Thr 
    4250                 4255                 4260             


Cys Ala  Gly Ala Thr Cys Ala  Thr Ala Thr Thr Gly  Cys Ala Ala 
    4265                 4270                 4275             


Ala Thr  Ala Ala Thr Thr Ala  Thr Gly Thr Gly Thr  Cys Thr Thr 
    4280                 4285                 4290             


Thr Ala  Thr Thr Ala Ala Thr  Thr Thr Cys Thr Ala  Thr Cys Gly 
    4295                 4300                 4305             


Thr Gly  Thr Gly Thr Gly Thr  Thr Thr Cys Thr Thr  Thr Thr Gly 
    4310                 4315                 4320             


Thr Cys  Ala Thr Thr Ala Gly  Thr Cys Thr Thr Cys  Ala Ala Ala 
    4325                 4330                 4335             


Ala Gly  Cys Ala Thr Gly Ala  Thr Thr Thr Cys Thr  Ala Ala Thr 
    4340                 4345                 4350             


Ala Gly  Thr Thr Gly Thr Ala  Gly Ala Gly Thr Gly  Ala Thr Thr 
    4355                 4360                 4365             


Cys Thr  Gly Cys Thr Thr Thr  Ala Thr Gly Ala Ala  Thr Thr Thr 
    4370                 4375                 4380             


Ala Thr  Cys Ala Cys Ala Ala  Cys Thr Cys Ala Thr  Gly Thr Ala 
    4385                 4390                 4395             


Ala Cys  Cys Ala Thr Thr Cys  Cys Thr Ala Thr Thr  Gly Gly Thr 
    4400                 4405                 4410             


Thr Gly  Gly Ala Cys Cys Ala  Gly Thr Thr Thr Ala  Thr Thr Gly 
    4415                 4420                 4425             


Thr Thr  Ala Ala Thr Thr Ala  Cys Thr Gly Thr Thr  Ala Ala Ala 
    4430                 4435                 4440             


Thr Ala  Ala Thr Gly Thr Thr  Thr Ala Ala Ala Ala  Ala Thr Ala 
    4445                 4450                 4455             


Thr Thr  Cys Thr Thr Gly Cys  Thr Ala Cys Ala Ala  Cys Ala Thr 
    4460                 4465                 4470             


Thr Ala  Ala Thr Thr Thr Thr  Cys Ala Thr Thr Thr  Cys Cys Thr 
    4475                 4480                 4485             


Thr Gly  Ala Gly Thr Gly Thr  Ala Gly Ala Cys Ala  Gly Ala Ala 
    4490                 4495                 4500             


Gly Thr  Ala Ala Thr Thr Cys  Thr Gly Thr Cys Cys  Cys Thr Thr 
    4505                 4510                 4515             


Gly Ala  Thr Gly Ala Ala Gly  Thr Ala Thr Thr Gly  Thr Ala Ala 
    4520                 4525                 4530             


Thr Ala  Ala Ala Thr Cys Thr  Gly Cys Cys Thr Gly  Ala Gly Gly 
    4535                 4540                 4545             


Cys Thr  Thr Thr Gly Cys Thr  Thr Cys Thr Thr Thr  Cys Cys Thr 
    4550                 4555                 4560             


Ala Ala  Thr Thr Ala Thr Ala  
    4565                 4570 


<210>  122
<211>  2805
<212>  PRT
<213>  Felis catus

<400>  122

Cys Ala Thr Gly Gly Thr Gly Ala Thr Thr Ala Gly Thr Gly Gly Ala 
1               5                   10                  15      


Cys Thr Ala Gly Gly Cys Thr Cys Ala Thr Gly Cys Cys Ala Ala Ala 
            20                  25                  30          


Ala Thr Cys Thr Gly Gly Cys Ala Thr Cys Thr Cys Thr Ala Cys Ala 
        35                  40                  45              


Ala Thr Ala Cys Thr Thr Cys Thr Thr Thr Cys Cys Gly Thr Cys Cys 
    50                  55                  60                  


Ala Ala Cys Thr Cys Ala Gly Gly Gly Ala Gly Gly Cys Cys Ala Gly 
65                  70                  75                  80  


Gly Thr Cys Thr Cys Cys Ala Thr Cys Gly Cys Cys Cys Thr Ala Ala 
                85                  90                  95      


Gly Cys Thr Cys Cys Cys Ala Cys Thr Gly Gly Ala Thr Cys Ala Ala 
            100                 105                 110         


Thr Cys Cys Thr Cys Gly Ala Ala Gly Ala Ala Thr Gly Ala Cys Cys 
        115                 120                 125             


Gly Ala Cys Cys Ala Cys Ala Gly Cys Ala Thr Cys Ala Ala Ala Gly 
    130                 135                 140                 


Ala Ala Thr Gly Thr Cys Ala Ala Ala Ala Gly Thr Cys Thr Cys Thr 
145                 150                 155                 160 


Thr Gly Ala Cys Thr Thr Thr Gly Thr Ala Cys Thr Ala Gly Gly Cys 
                165                 170                 175     


Thr Gly Gly Thr Thr Thr Gly Cys Cys Ala Ala Ala Cys Cys Cys Ala 
            180                 185                 190         


Thr Ala Thr Thr Thr Ala Thr Thr Gly Ala Thr Gly Gly Thr Gly Ala 
        195                 200                 205             


Cys Thr Ala Thr Cys Cys Thr Gly Ala Gly Ala Gly Cys Ala Thr Gly 
    210                 215                 220                 


Ala Ala Gly Ala Ala Thr Ala Ala Thr Cys Thr Thr Thr Cys Ala Cys 
225                 230                 235                 240 


Ala Thr Cys Thr Thr Cys Thr Gly Cys Cys Thr Gly Ala Thr Thr Thr 
                245                 250                 255     


Thr Ala Cys Thr Gly Ala Ala Gly Cys Thr Gly Ala Gly Ala Ala Ala 
            260                 265                 270         


Ala Ala Gly Thr Thr Cys Ala Thr Thr Ala Ala Gly Gly Gly Ala Ala 
        275                 280                 285             


Cys Ala Gly Cys Thr Gly Ala Cys Thr Thr Thr Thr Thr Thr Gly Cys 
    290                 295                 300                 


Thr Cys Thr Thr Thr Cys Thr Thr Thr Thr Gly Gly Ala Cys Cys Ala 
305                 310                 315                 320 


Ala Cys Cys Thr Thr Gly Ala Gly Thr Thr Thr Thr Cys Ala Ala Cys 
                325                 330                 335     


Thr Ala Thr Thr Gly Gly Ala Cys Cys Cys Cys Cys Ala Cys Ala Thr 
            340                 345                 350         


Gly Ala Ala Gly Thr Thr Cys Cys Gly Cys Cys Ala Gly Thr Thr Ala 
        355                 360                 365             


Gly Ala Ala Thr Cys Thr Cys Cys Cys Ala Gly Cys Cys Thr Gly Ala 
    370                 375                 380                 


Gly Gly Cys Ala Ala Cys Thr Cys Cys Thr Thr Thr Cys Thr Thr Gly 
385                 390                 395                 400 


Gly Ala Thr Thr Gly Ala Cys Cys Thr Thr Gly Ala Ala Thr Ala Thr 
                405                 410                 415     


Ala Ala Cys Cys Ala Cys Cys Cys Thr Cys Ala Ala Ala Thr Ala Thr 
            420                 425                 430         


Thr Thr Ala Thr Thr Gly Thr Gly Gly Ala Ala Ala Ala Thr Gly Gly 
        435                 440                 445             


Cys Thr Gly Gly Thr Thr Thr Gly Thr Cys Thr Cys Ala Gly Gly Gly 
    450                 455                 460                 


Ala Cys Cys Ala Cys Cys Ala Ala Gly Ala Gly Ala Gly Ala Cys Gly 
465                 470                 475                 480 


Ala Cys Gly Cys Cys Ala Ala Ala Thr Ala Thr Ala Thr Gly Thr Ala 
                485                 490                 495     


Thr Thr Ala Cys Cys Thr Cys Ala Ala Ala Ala Ala Ala Thr Thr Cys 
            500                 505                 510         


Gly Thr Ala Ala Thr Gly Gly Ala Ala Ala Cys Cys Thr Thr Ala Ala 
        515                 520                 525             


Ala Ala Gly Cys Cys Ala Thr Thr Ala Gly Gly Cys Thr Gly Gly Ala 
    530                 535                 540                 


Thr Gly Gly Gly Gly Thr Gly Gly Ala Cys Gly Thr Cys Ala Thr Thr 
545                 550                 555                 560 


Gly Gly Gly Thr Ala Cys Ala Cys Gly Gly Cys Cys Thr Gly Gly Thr 
                565                 570                 575     


Cys Cys Cys Thr Thr Ala Thr Gly Gly Ala Thr Gly Gly Cys Thr Thr 
            580                 585                 590         


Cys Gly Ala Ala Thr Gly Gly Cys Ala Cys Ala Gly Ala Gly Gly Thr 
        595                 600                 605             


Thr Ala Cys Ala Gly Cys Ala Thr Cys Ala Gly Gly Cys Gly Thr Gly 
    610                 615                 620                 


Gly Ala Cys Thr Cys Thr Thr Cys Thr Ala Thr Gly Thr Thr Gly Ala 
625                 630                 635                 640 


Cys Thr Thr Thr Cys Thr Ala Ala Gly Cys Cys Ala Gly Gly Ala Thr 
                645                 650                 655     


Ala Ala Gly Ala Ala Ala Cys Thr Gly Thr Thr Gly Cys Cys Gly Ala 
            660                 665                 670         


Ala Ala Thr Cys Thr Thr Cys Ala Gly Cys Cys Thr Thr Gly Thr Thr 
        675                 680                 685             


Cys Thr Ala Cys Cys Ala Ala Ala Ala Gly Cys Thr Gly Ala Thr Ala 
    690                 695                 700                 


Gly Ala Gly Ala Ala Ala Ala Ala Thr Gly Gly Cys Thr Thr Cys Cys 
705                 710                 715                 720 


Cys Thr Cys Cys Thr Thr Thr Ala Cys Cys Thr Gly Ala Ala Ala Ala 
                725                 730                 735     


Thr Cys Ala Ala Cys Cys Thr Cys Thr Ala Gly Ala Ala Gly Gly Gly 
            740                 745                 750         


Ala Cys Ala Thr Thr Thr Cys Cys Cys Thr Gly Thr Gly Ala Cys Thr 
        755                 760                 765             


Thr Thr Gly Cys Thr Thr Gly Gly Gly Gly Ala Ala Thr Thr Gly Thr 
    770                 775                 780                 


Thr Gly Ala Cys Ala Ala Cys Thr Ala Cys Ala Thr Thr Cys Ala Ala 
785                 790                 795                 800 


Gly Thr Gly Gly Ala Cys Ala Cys Cys Ala Cys Thr Cys Thr Gly Thr 
                805                 810                 815     


Cys Thr Cys Ala Gly Thr Thr Thr Ala Cys Cys Gly Ala Cys Cys Cys 
            820                 825                 830         


Gly Ala Ala Cys Gly Thr Thr Thr Ala Cys Cys Thr Gly Thr Gly Gly 
        835                 840                 845             


Gly Ala Cys Gly Thr Cys Cys Ala Cys Cys Ala Cys Ala Gly Thr Ala 
    850                 855                 860                 


Ala Gly Ala Gly Gly Cys Thr Ala Ala Thr Thr Ala Ala Gly Gly Thr 
865                 870                 875                 880 


Gly Gly Ala Cys Gly Gly Gly Gly Thr Thr Gly Thr Gly Ala Cys Cys 
                885                 890                 895     


Ala Ala Gly Ala Ala Gly Cys Gly Gly Ala Ala Gly Thr Cys Cys Thr 
            900                 905                 910         


Ala Cys Thr Gly Cys Gly Thr Gly Gly Ala Cys Thr Thr Cys Gly Cys 
        915                 920                 925             


Thr Gly Cys Cys Ala Thr Cys Cys Gly Gly Cys Cys Cys Cys Ala Gly 
    930                 935                 940                 


Ala Thr Ala Gly Cys Cys Thr Thr Ala Cys Thr Cys Cys Ala Gly Gly 
945                 950                 955                 960 


Ala Gly Ala Thr Gly Cys Ala Cys Gly Thr Thr Thr Cys Cys Cys Ala 
                965                 970                 975     


Thr Thr Thr Cys Cys Ala Cys Thr Thr Cys Thr Cys Cys Cys Thr Gly 
            980                 985                 990         


Gly Ala Cys Thr Gly Gly Gly Cys  Cys Cys Thr Gly Ala  Thr Cys Cys 
        995                 1000                 1005             


Thr Gly  Cys Cys Gly Cys Thr  Gly Gly Gly Cys Ala  Ala Cys Cys 
    1010                 1015                 1020             


Ala Gly  Thr Cys Cys Cys Ala  Gly Gly Thr Gly Ala  Ala Cys Cys 
    1025                 1030                 1035             


Ala Cys  Ala Cys Gly Gly Thr  Cys Cys Thr Cys Gly  Ala Cys Thr 
    1040                 1045                 1050             


Ala Cys  Thr Ala Cys Cys Gly  Cys Thr Gly Cys Gly  Thr Gly Gly 
    1055                 1060                 1065             


Thr Cys  Ala Gly Cys Gly Ala  Gly Cys Thr Cys Gly  Thr Gly Cys 
    1070                 1075                 1080             


Gly Cys  Gly Cys Cys Ala Ala  Cys Ala Thr Cys Ala  Cys Cys Cys 
    1085                 1090                 1095             


Cys Gly  Gly Thr Gly Gly Thr  Gly Gly Cys Gly Cys  Thr Cys Thr 
    1100                 1105                 1110             


Gly Gly  Cys Gly Ala Cys Cys  Cys Gly Cys Gly Gly  Cys Cys Cys 
    1115                 1120                 1125             


Cys Gly  Cys Ala Cys Cys Ala  Ala Gly Gly Gly Cys  Thr Gly Cys 
    1130                 1135                 1140             


Cys Gly  Cys Gly Gly Cys Cys  Cys Cys Thr Gly Gly  Cys Cys Ala 
    1145                 1150                 1155             


Ala Gly  Cys Ala Cys Gly Gly  Ala Gly Cys Cys Thr  Gly Gly Gly 
    1160                 1165                 1170             


Ala Gly  Ala Ala Cys Cys Cys  Ala Cys Ala Cys Ala  Cys Cys Gly 
    1175                 1180                 1185             


Cys Cys  Thr Cys Gly Gly Cys  Thr Thr Thr Thr Gly  Cys Ala Gly 
    1190                 1195                 1200             


Ala Gly  Thr Ala Cys Gly Cys  Cys Cys Gly Gly Cys  Thr Gly Thr 
    1205                 1210                 1215             


Gly Cys  Thr Thr Cys Ala Ala  Gly Gly Ala Thr Cys  Thr Cys Gly 
    1220                 1225                 1230             


Gly Cys  Cys Ala Cys Cys Ala  Cys Gly Thr Cys Ala  Ala Gly Thr 
    1235                 1240                 1245             


Thr Cys  Thr Gly Gly Ala Thr  Cys Ala Cys Gly Ala  Thr Gly Gly 
    1250                 1255                 1260             


Gly Cys  Gly Ala Gly Cys Cys  Gly Thr Ala Cys Ala  Cys Ala Cys 
    1265                 1270                 1275             


Gly Gly  Ala Ala Cys Ala Thr  Gly Ala Cys Cys Thr  Ala Cys Ala 
    1280                 1285                 1290             


Gly Cys  Gly Cys Gly Gly Gly  Gly Cys Ala Cys Ala  Ala Thr Cys 
    1295                 1300                 1305             


Thr Thr  Cys Thr Gly Ala Ala  Gly Gly Cys Thr Cys  Ala Cys Gly 
    1310                 1315                 1320             


Cys Gly  Thr Thr Gly Gly Cys  Cys Thr Gly Gly Cys  Gly Cys Gly 
    1325                 1330                 1335             


Thr Gly  Thr Ala Cys Gly Ala  Thr Gly Ala Ala Ala  Ala Cys Thr 
    1340                 1345                 1350             


Thr Thr  Cys Gly Gly Gly Gly  Cys Thr Cys Thr Cys  Ala Gly Ala 
    1355                 1360                 1365             


Ala Gly  Gly Gly Gly Ala Ala  Ala Ala Thr Ala Thr  Cys Cys Ala 
    1370                 1375                 1380             


Thr Ala  Gly Cys Cys Cys Thr  Gly Cys Ala Gly Gly  Cys Cys Gly 
    1385                 1390                 1395             


Ala Cys  Thr Gly Gly Ala Thr  Ala Gly Ala Gly Cys  Cys Gly Gly 
    1400                 1405                 1410             


Cys Cys  Thr Gly Cys Cys Cys  Thr Thr Thr Cys Thr  Cys Cys Cys 
    1415                 1420                 1425             


Ala Ala  Ala Ala Gly Gly Ala  Cys Ala Ala Ala Gly  Ala Ala Gly 
    1430                 1435                 1440             


Thr Gly  Gly Cys Ala Gly Ala  Gly Ala Gly Ala Gly  Thr Thr Thr 
    1445                 1450                 1455             


Thr Gly  Gly Ala Ala Thr Thr  Thr Gly Ala Cys Ala  Thr Thr Gly 
    1460                 1465                 1470             


Gly Cys  Thr Gly Gly Cys Thr  Gly Gly Cys Cys Gly  Ala Gly Cys 
    1475                 1480                 1485             


Cys Cys  Ala Thr Thr Thr Thr  Cys Gly Gly Cys Thr  Cys Thr Gly 
    1490                 1495                 1500             


Gly Gly  Gly Ala Thr Thr Ala  Thr Cys Cys Gly Cys  Gly Thr Gly 
    1505                 1510                 1515             


Thr Gly  Ala Thr Gly Ala Gly  Gly Gly Ala Cys Thr  Gly Gly Cys 
    1520                 1525                 1530             


Thr Cys  Ala Cys Gly Cys Ala  Gly Ala Gly Ala Ala  Ala Cys Ala 
    1535                 1540                 1545             


Ala Thr  Thr Thr Cys Cys Thr  Thr Cys Thr Ala Cys  Cys Thr Thr 
    1550                 1555                 1560             


Ala Thr  Thr Thr Cys Ala Cys  Thr Gly Ala Ala Gly  Ala Thr Gly 
    1565                 1570                 1575             


Ala Ala  Ala Ala Ala Ala Ala  Gly Cys Thr Ala Ala  Thr Cys Cys 
    1580                 1585                 1590             


Gly Gly  Gly Gly Thr Thr Cys  Cys Thr Thr Cys Gly  Ala Cys Thr 
    1595                 1600                 1605             


Thr Thr  Cys Thr Gly Gly Cys  Cys Gly Thr Ala Ala  Gly Cys Cys 
    1610                 1615                 1620             


Ala Thr  Thr Ala Cys Ala Cys  Cys Ala Cys Cys Ala  Thr Cys Cys 
    1625                 1630                 1635             


Thr Cys  Gly Thr Cys Gly Ala  Cys Thr Gly Gly Gly  Ala Ala Ala 
    1640                 1645                 1650             


Ala Ala  Gly Ala Ala Gly Ala  Thr Cys Cys Ala Ala  Thr Gly Ala 
    1655                 1660                 1665             


Ala Ala  Thr Ala Cys Ala Ala  Cys Gly Ala Thr Thr  Ala Cys Cys 
    1670                 1675                 1680             


Thr Gly  Gly Ala Gly Gly Thr  Gly Cys Ala Gly Gly  Ala Ala Ala 
    1685                 1690                 1695             


Thr Gly  Ala Cys Cys Gly Ala  Cys Ala Thr Cys Ala  Cys Gly Thr 
    1700                 1705                 1710             


Gly Gly  Cys Thr Cys Ala Ala  Cys Thr Cys Cys Cys  Cys Cys Ala 
    1715                 1720                 1725             


Gly Thr  Cys Ala Gly Gly Thr  Gly Gly Cys Ala Gly  Thr Ala Gly 
    1730                 1735                 1740             


Thr Gly  Cys Cys Cys Thr Gly  Gly Gly Gly Cys Thr  Thr Ala Cys 
    1745                 1750                 1755             


Gly Cys  Ala Ala Ala Ala Thr  Thr Cys Thr Cys Ala  Ala Cys Thr 
    1760                 1765                 1770             


Gly Gly  Cys Thr Gly Ala Ala  Gly Cys Thr Gly Ala  Ala Gly Thr 
    1775                 1780                 1785             


Ala Cys  Gly Gly Ala Gly Ala  Cys Cys Thr Cys Cys  Cys Cys Ala 
    1790                 1795                 1800             


Thr Gly  Thr Ala Thr Ala Thr  Ala Ala Thr Ala Thr  Cys Cys Ala 
    1805                 1810                 1815             


Ala Cys  Gly Gly Cys Ala Thr  Ala Gly Ala Cys Gly  Ala Cys Gly 
    1820                 1825                 1830             


Ala Thr  Cys Cys Gly Cys Ala  Gly Gly Cys Ala Gly  Cys Gly Cys 
    1835                 1840                 1845             


Ala Ala  Gly Ala Cys Ala Ala  Gly Cys Thr Gly Ala  Gly Gly Gly 
    1850                 1855                 1860             


Thr Gly  Thr Ala Thr Thr Ala  Cys Ala Thr Gly Cys  Ala Ala Ala 
    1865                 1870                 1875             


Ala Thr  Thr Ala Thr Gly Thr  Ala Ala Ala Thr Gly  Ala Ala Gly 
    1880                 1885                 1890             


Cys Thr  Cys Thr Gly Ala Ala  Ala Gly Cys Cys Thr  Ala Cys Gly 
    1895                 1900                 1905             


Thr Ala  Thr Thr Gly Gly Ala  Thr Gly Gly Thr Gly  Thr Cys Ala 
    1910                 1915                 1920             


Ala Thr  Cys Thr Thr Thr Gly  Thr Gly Gly Ala Thr  Ala Cys Thr 
    1925                 1930                 1935             


Thr Thr  Gly Cys Thr Thr Ala  Thr Thr Cys Ala Thr  Thr Cys Ala 
    1940                 1945                 1950             


Ala Thr  Gly Ala Thr Cys Gly  Cys Ala Cys Ala Gly  Cys Thr Cys 
    1955                 1960                 1965             


Cys Ala  Ala Ala Gly Thr Thr  Thr Gly Gly Cys Thr  Thr Cys Thr 
    1970                 1975                 1980             


Ala Thr  Cys Ala Thr Thr Ala  Cys Gly Cys Thr Gly  Cys Ala Ala 
    1985                 1990                 1995             


Ala Thr  Cys Ala Gly Thr Thr  Thr Gly Ala Gly Cys  Cys Cys Ala 
    2000                 2005                 2010             


Ala Ala  Cys Cys Gly Thr Cys  Cys Ala Thr Gly Ala  Ala Ala Cys 
    2015                 2020                 2025             


Ala Thr  Thr Ala Thr Cys Gly  Gly Ala Ala Ala Ala  Thr Gly Ala 
    2030                 2035                 2040             


Thr Thr  Gly Ala Cys Ala Gly  Cys Ala Ala Thr Gly  Gly Cys Thr 
    2045                 2050                 2055             


Thr Cys  Thr Cys Cys Gly Gly  Thr Cys Cys Thr Gly  Ala Cys Ala 
    2060                 2065                 2070             


Cys Thr  Cys Thr Gly Gly Gly  Gly Ala Gly Ala Thr  Thr Thr Thr 
    2075                 2080                 2085             


Gly Thr  Cys Cys Ala Gly Ala  Ala Gly Ala Ala Thr  Thr Cys Ala 
    2090                 2095                 2100             


Cys Cys  Cys Thr Gly Thr Gly  Cys Ala Cys Cys Gly  Ala Ala Thr 
    2105                 2110                 2115             


Gly Cys  Gly Gly Cys Thr Thr  Thr Thr Thr Thr Cys  Ala Cys Ala 
    2120                 2125                 2130             


Cys Cys  Cys Gly Cys Ala Ala  Ala Thr Cys Thr Thr  Thr Ala Cys 
    2135                 2140                 2145             


Thr Gly  Gly Cys Thr Thr Thr  Cys Ala Thr Ala Gly  Cys Thr Thr 
    2150                 2155                 2160             


Thr Cys  Cys Thr Ala Cys Thr  Thr Thr Thr Thr Gly  Cys Thr Thr 
    2165                 2170                 2175             


Thr Thr  Ala Thr Thr Ala Thr  Thr Thr Cys Thr Cys  Thr Thr Thr 
    2180                 2185                 2190             


Cys Thr  Cys Thr Gly Ala Thr  Thr Thr Thr Thr Thr  Ala Cys Thr 
    2195                 2200                 2205             


Ala Cys  Thr Cys Thr Ala Ala  Gly Ala Ala Ala Gly  Gly Cys Ala 
    2210                 2215                 2220             


Ala Ala  Ala Gly Ala Ala Gly  Thr Thr Ala Cys Ala  Ala Gly Thr 
    2225                 2230                 2235             


Ala Gly  Thr Cys Cys Thr Gly  Ala Cys Cys Thr Thr  Thr Thr Thr 
    2240                 2245                 2250             


Cys Cys  Thr Ala Thr Thr Cys  Ala Thr Thr Thr Ala  Cys Thr Thr 
    2255                 2260                 2265             


Thr Gly  Ala Ala Ala Thr Gly  Ala Thr Thr Ala Thr  Gly Cys Ala 
    2270                 2275                 2280             


Cys Ala  Cys Ala Cys Ala Thr  Cys Ala Gly Cys Thr  Gly Thr Thr 
    2285                 2290                 2295             


Cys Ala  Cys Cys Ala Thr Thr  Thr Gly Cys Ala Cys  Thr Thr Cys 
    2300                 2305                 2310             


Thr Cys  Ala Gly Thr Gly Thr  Cys Gly Thr Ala Ala  Gly Ala Cys 
    2315                 2320                 2325             


Thr Gly  Gly Ala Thr Thr Thr  Cys Ala Cys Thr Thr  Ala Thr Cys 
    2330                 2335                 2340             


Thr Gly  Ala Cys Thr Thr Cys  Thr Ala Gly Ala Ala  Ala Ala Ala 
    2345                 2350                 2355             


Ala Ala  Ala Thr Gly Thr Gly  Thr Gly Gly Cys Gly  Thr Ala Thr 
    2360                 2365                 2370             


Gly Ala  Cys Ala Gly Ala Gly  Gly Thr Ala Thr Gly  Gly Ala Ala 
    2375                 2380                 2385             


Gly Thr  Gly Ala Gly Cys Ala  Thr Ala Gly Gly Thr  Gly Ala Thr 
    2390                 2395                 2400             


Thr Gly  Thr Ala Ala Ala Ala  Thr Ala Cys Thr Gly  Ala Ala Thr 
    2405                 2410                 2415             


Ala Ala  Thr Gly Thr Gly Ala  Ala Thr Ala Gly Thr  Gly Cys Cys 
    2420                 2425                 2430             


Thr Gly  Gly Ala Thr Thr Thr  Gly Thr Thr Cys Thr  Thr Thr Cys 
    2435                 2440                 2445             


Thr Thr  Gly Gly Ala Gly Gly  Ala Thr Gly Ala Thr  Cys Ala Ala 
    2450                 2455                 2460             


Ala Gly  Ala Cys Gly Gly Thr  Thr Ala Gly Gly Gly  Gly Cys Cys 
    2465                 2470                 2475             


Ala Thr  Cys Ala Thr Cys Thr  Cys Thr Gly Cys Ala  Ala Cys Ala 
    2480                 2485                 2490             


Cys Ala  Thr Thr Cys Thr Gly  Thr Ala Ala Cys Ala  Ala Ala Thr 
    2495                 2500                 2505             


Gly Thr  Ala Thr Gly Gly Gly  Ala Ala Gly Thr Gly  Gly Gly Ala 
    2510                 2515                 2520             


Cys Cys  Cys Ala Thr Thr Cys  Thr Gly Gly Ala Ala  Cys Ala Thr 
    2525                 2530                 2535             


Thr Thr  Thr Thr Ala Thr Ala  Gly Ala Ala Ala Thr  Thr Gly Ala 
    2540                 2545                 2550             


Ala Thr  Ala Gly Cys Ala Ala  Gly Ala Thr Cys Ala  Gly Thr Gly 
    2555                 2560                 2565             


Cys Cys  Cys Gly Thr Thr Cys  Cys Thr Ala Ala Ala  Thr Thr Ala 
    2570                 2575                 2580             


Thr Cys  Thr Thr Gly Ala Ala  Gly Thr Ala Ala Ala  Ala Cys Ala 
    2585                 2590                 2595             


Ala Ala  Thr Gly Thr Gly Gly  Ala Ala Ala Thr Ala  Ala Ala Ala 
    2600                 2605                 2610             


Ala Gly  Thr Thr Ala Ala Gly  Thr Cys Cys Cys Ala  Ala Ala Thr 
    2615                 2620                 2625             


Ala Ala  Cys Cys Ala Thr Cys  Thr Cys Thr Ala Ala  Ala Cys Thr 
    2630                 2635                 2640             


Thr Cys  Cys Ala Thr Gly Ala  Thr Ala Thr Gly Cys  Cys Thr Ala 
    2645                 2650                 2655             


Ala Thr  Gly Gly Thr Cys Thr  Cys Thr Gly Thr Thr  Gly Gly Ala 
    2660                 2665                 2670             


Cys Cys  Cys Ala Gly Thr Thr  Thr Cys Cys Cys Thr  Thr Gly Ala 
    2675                 2680                 2685             


Ala Ala  Ala Ala Gly Ala Ala  Ala Thr Gly Gly Thr  Ala Gly Ala 
    2690                 2695                 2700             


Ala Thr  Ala Thr Thr Ala Gly  Ala Gly Ala Cys Ala  Thr Gly Ala 
    2705                 2710                 2715             


Cys Ala  Gly Ala Gly Gly Gly  Cys Cys Cys Thr Ala  Cys Gly Cys 
    2720                 2725                 2730             


Thr Ala  Gly Ala Ala Cys Gly  Thr Thr Cys Cys Thr  Thr Thr Thr 
    2735                 2740                 2745             


Ala Thr  Thr Thr Thr Thr Thr  Thr Thr Thr Thr Thr  Ala Ala Ala 
    2750                 2755                 2760             


Thr Thr  Thr Thr Thr Thr Thr  Thr Cys Ala Ala Thr  Gly Thr Thr 
    2765                 2770                 2775             


Thr Thr  Thr Ala Thr Thr Thr  Ala Thr Thr Thr Thr  Thr Gly Gly 
    2780                 2785                 2790             


Gly Ala  Cys Ala Gly Ala Gly  Ala Gly Ala Gly Ala  
    2795                 2800                 2805 


<210>  123
<211>  3178
<212>  PRT
<213>  Felis catus

<400>  123

Gly Gly Gly Gly Thr Cys Ala Cys Cys Cys Ala Cys Thr Ala Cys Cys 
1               5                   10                  15      


Gly Cys Thr Thr Cys Thr Cys Cys Ala Thr Cys Thr Cys Gly Thr Gly 
            20                  25                  30          


Gly Gly Cys Gly Cys Gly Gly Gly Thr Gly Cys Thr Cys Cys Cys Cys 
        35                  40                  45              


Ala Ala Thr Gly Gly Cys Ala Gly Cys Gly Cys Gly Gly Gly Cys Gly 
    50                  55                  60                  


Cys Cys Cys Cys Cys Ala Ala Cys Cys Gly Cys Gly Ala Gly Gly Gly 
65                  70                  75                  80  


Gly Cys Thr Gly Cys Gly Cys Thr Ala Cys Thr Ala Cys Cys Gly Gly 
                85                  90                  95      


Cys Gly Cys Cys Thr Gly Cys Thr Gly Gly Ala Gly Cys Gly Gly Cys 
            100                 105                 110         


Thr Gly Cys Gly Gly Gly Ala Gly Cys Thr Gly Gly Gly Cys Gly Thr 
        115                 120                 125             


Gly Cys Ala Gly Cys Cys Cys Gly Thr Gly Gly Thr Cys Ala Cys Cys 
    130                 135                 140                 


Cys Thr Gly Thr Ala Cys Cys Ala Cys Thr Ala Gly Gly Ala Cys Cys 
145                 150                 155                 160 


Thr Gly Cys Cys Cys Cys Ala Gly Cys Gly Cys Cys Thr Gly Cys Ala 
                165                 170                 175     


Gly Gly Ala Cys Gly Cys Cys Thr Ala Cys Gly Gly Cys Gly Gly Cys 
            180                 185                 190         


Thr Gly Gly Gly Cys Cys Ala Ala Cys Cys Gly Cys Gly Cys Cys Cys 
        195                 200                 205             


Thr Gly Gly Cys Cys Gly Ala Cys Cys Ala Cys Thr Thr Cys Ala Gly 
    210                 215                 220                 


Gly Gly Ala Thr Thr Ala Cys Gly Cys Cys Gly Ala Gly Cys Thr Cys 
225                 230                 235                 240 


Thr Gly Cys Thr Thr Cys Cys Gly Cys Cys Ala Cys Thr Thr Cys Gly 
                245                 250                 255     


Gly Cys Gly Gly Cys Cys Ala Gly Gly Thr Cys Ala Ala Gly Thr Ala 
            260                 265                 270         


Cys Thr Gly Gly Ala Thr Cys Ala Cys Cys Ala Thr Cys Gly Ala Cys 
        275                 280                 285             


Ala Ala Cys Cys Cys Cys Thr Ala Cys Gly Thr Gly Gly Thr Gly Gly 
    290                 295                 300                 


Cys Cys Thr Gly Gly Cys Ala Cys Gly Gly Cys Thr Ala Cys Gly Cys 
305                 310                 315                 320 


Cys Ala Cys Cys Gly Gly Gly Cys Gly Cys Cys Thr Gly Gly Cys Cys 
                325                 330                 335     


Cys Cys Thr Gly Gly Cys Gly Thr Cys Cys Gly Gly Gly Gly Cys Ala 
            340                 345                 350         


Gly Cys Gly Cys Gly Cys Gly Gly Cys Thr Cys Gly Gly Gly Thr Ala 
        355                 360                 365             


Cys Cys Thr Gly Gly Thr Gly Gly Cys Gly Cys Ala Cys Ala Ala Cys 
    370                 375                 380                 


Cys Thr Cys Cys Thr Cys Cys Thr Gly Gly Cys Thr Cys Ala Thr Gly 
385                 390                 395                 400 


Cys Cys Ala Ala Ala Ala Thr Cys Thr Gly Gly Cys Ala Thr Cys Thr 
                405                 410                 415     


Cys Thr Ala Cys Ala Ala Thr Ala Cys Thr Thr Cys Thr Thr Thr Cys 
            420                 425                 430         


Cys Gly Thr Cys Cys Ala Ala Cys Thr Cys Ala Gly Gly Gly Ala Gly 
        435                 440                 445             


Gly Cys Cys Ala Gly Gly Thr Cys Thr Cys Cys Ala Thr Cys Gly Cys 
    450                 455                 460                 


Cys Cys Thr Ala Ala Gly Cys Thr Cys Cys Cys Ala Cys Thr Gly Gly 
465                 470                 475                 480 


Ala Thr Cys Ala Ala Thr Cys Cys Thr Cys Gly Ala Ala Gly Ala Ala 
                485                 490                 495     


Thr Gly Ala Cys Cys Gly Ala Cys Cys Ala Cys Ala Gly Cys Ala Thr 
            500                 505                 510         


Cys Ala Ala Ala Gly Ala Ala Thr Gly Thr Cys Ala Ala Ala Ala Gly 
        515                 520                 525             


Thr Cys Thr Cys Thr Thr Gly Ala Cys Thr Thr Thr Gly Thr Ala Cys 
    530                 535                 540                 


Thr Ala Gly Gly Cys Thr Gly Gly Thr Thr Thr Gly Cys Cys Ala Ala 
545                 550                 555                 560 


Ala Cys Cys Cys Ala Thr Ala Thr Thr Thr Ala Thr Thr Gly Ala Thr 
                565                 570                 575     


Gly Gly Thr Gly Ala Cys Thr Ala Thr Cys Cys Thr Gly Ala Gly Ala 
            580                 585                 590         


Gly Cys Ala Thr Gly Ala Ala Gly Ala Ala Thr Ala Ala Thr Cys Thr 
        595                 600                 605             


Thr Thr Cys Ala Cys Ala Thr Cys Thr Thr Cys Thr Gly Cys Cys Thr 
    610                 615                 620                 


Gly Ala Thr Thr Thr Thr Ala Cys Thr Gly Ala Ala Gly Cys Thr Gly 
625                 630                 635                 640 


Ala Gly Ala Ala Ala Ala Ala Gly Thr Thr Cys Ala Thr Thr Ala Ala 
                645                 650                 655     


Gly Gly Gly Ala Ala Cys Ala Gly Cys Thr Gly Ala Cys Thr Thr Thr 
            660                 665                 670         


Thr Thr Thr Gly Cys Thr Cys Thr Thr Thr Cys Thr Thr Thr Thr Gly 
        675                 680                 685             


Gly Ala Cys Cys Ala Ala Cys Cys Thr Thr Gly Ala Gly Thr Thr Thr 
    690                 695                 700                 


Thr Cys Ala Ala Cys Thr Ala Thr Thr Gly Gly Ala Cys Cys Cys Cys 
705                 710                 715                 720 


Cys Ala Cys Ala Thr Gly Ala Ala Gly Thr Thr Cys Cys Gly Cys Cys 
                725                 730                 735     


Ala Gly Thr Thr Ala Gly Ala Ala Thr Cys Thr Cys Cys Cys Ala Gly 
            740                 745                 750         


Cys Cys Thr Gly Ala Gly Gly Cys Ala Ala Cys Thr Cys Cys Thr Thr 
        755                 760                 765             


Thr Cys Thr Thr Gly Gly Ala Thr Thr Gly Ala Cys Cys Thr Thr Gly 
    770                 775                 780                 


Ala Ala Thr Ala Thr Ala Ala Cys Cys Ala Cys Cys Cys Thr Cys Ala 
785                 790                 795                 800 


Ala Ala Thr Ala Thr Thr Thr Ala Thr Thr Gly Thr Gly Gly Ala Ala 
                805                 810                 815     


Ala Ala Thr Gly Gly Cys Thr Gly Gly Thr Thr Thr Gly Thr Cys Thr 
            820                 825                 830         


Cys Ala Gly Gly Gly Ala Cys Cys Ala Cys Cys Ala Ala Gly Ala Gly 
        835                 840                 845             


Ala Gly Ala Cys Gly Ala Cys Gly Cys Cys Ala Ala Ala Thr Ala Thr 
    850                 855                 860                 


Ala Thr Gly Thr Ala Thr Thr Ala Cys Cys Thr Cys Ala Ala Ala Ala 
865                 870                 875                 880 


Ala Ala Thr Thr Cys Gly Thr Ala Ala Thr Gly Gly Ala Ala Ala Cys 
                885                 890                 895     


Cys Thr Thr Ala Ala Ala Ala Gly Cys Cys Ala Thr Thr Ala Gly Gly 
            900                 905                 910         


Cys Thr Gly Gly Ala Thr Gly Gly Gly Gly Thr Gly Gly Ala Cys Gly 
        915                 920                 925             


Thr Cys Ala Thr Thr Gly Gly Gly Thr Ala Cys Ala Cys Gly Gly Cys 
    930                 935                 940                 


Cys Thr Gly Gly Thr Cys Cys Cys Thr Thr Ala Thr Gly Gly Ala Thr 
945                 950                 955                 960 


Gly Gly Cys Thr Thr Cys Gly Ala Ala Thr Gly Gly Cys Ala Cys Ala 
                965                 970                 975     


Gly Ala Gly Gly Thr Thr Ala Cys Ala Gly Cys Ala Thr Cys Ala Gly 
            980                 985                 990         


Gly Cys Gly Thr Gly Gly Ala Cys  Thr Cys Thr Thr Cys  Thr Ala Thr 
        995                 1000                 1005             


Gly Thr  Thr Gly Ala Cys Thr  Thr Thr Cys Thr Ala  Ala Gly Cys 
    1010                 1015                 1020             


Cys Ala  Gly Gly Ala Thr Ala  Ala Gly Ala Ala Ala  Cys Thr Gly 
    1025                 1030                 1035             


Thr Thr  Gly Cys Cys Gly Ala  Ala Ala Thr Cys Thr  Thr Cys Ala 
    1040                 1045                 1050             


Gly Cys  Cys Thr Thr Gly Thr  Thr Cys Thr Ala Cys  Cys Ala Ala 
    1055                 1060                 1065             


Ala Ala  Gly Cys Thr Gly Ala  Thr Ala Gly Ala Gly  Ala Ala Ala 
    1070                 1075                 1080             


Ala Ala  Thr Gly Gly Cys Thr  Thr Cys Cys Cys Thr  Cys Cys Thr 
    1085                 1090                 1095             


Thr Thr  Ala Cys Cys Thr Gly  Ala Ala Ala Ala Thr  Cys Ala Ala 
    1100                 1105                 1110             


Cys Cys  Thr Cys Thr Ala Gly  Ala Ala Gly Gly Gly  Ala Cys Ala 
    1115                 1120                 1125             


Thr Thr  Thr Cys Cys Cys Thr  Gly Thr Gly Ala Cys  Thr Thr Thr 
    1130                 1135                 1140             


Gly Cys  Thr Thr Gly Gly Gly  Gly Ala Ala Thr Thr  Gly Thr Thr 
    1145                 1150                 1155             


Gly Ala  Cys Ala Ala Cys Thr  Ala Cys Ala Thr Thr  Cys Ala Ala 
    1160                 1165                 1170             


Gly Thr  Gly Gly Ala Cys Ala  Cys Cys Ala Cys Thr  Cys Thr Gly 
    1175                 1180                 1185             


Thr Cys  Thr Cys Ala Gly Thr  Thr Thr Ala Cys Cys  Gly Ala Cys 
    1190                 1195                 1200             


Cys Cys  Gly Ala Ala Cys Gly  Thr Thr Thr Ala Cys  Cys Thr Gly 
    1205                 1210                 1215             


Thr Gly  Gly Gly Ala Cys Gly  Thr Cys Cys Ala Cys  Cys Ala Cys 
    1220                 1225                 1230             


Ala Gly  Thr Ala Ala Gly Ala  Gly Gly Cys Thr Ala  Ala Thr Thr 
    1235                 1240                 1245             


Ala Ala  Gly Gly Thr Gly Gly  Ala Cys Gly Gly Gly  Gly Thr Thr 
    1250                 1255                 1260             


Gly Thr  Gly Ala Cys Cys Ala  Ala Gly Ala Ala Gly  Cys Gly Gly 
    1265                 1270                 1275             


Ala Ala  Gly Thr Cys Cys Thr  Ala Cys Thr Gly Cys  Gly Thr Gly 
    1280                 1285                 1290             


Gly Ala  Cys Thr Thr Cys Gly  Cys Thr Gly Cys Cys  Ala Thr Cys 
    1295                 1300                 1305             


Cys Gly  Gly Cys Cys Cys Cys  Ala Gly Ala Thr Ala  Gly Cys Cys 
    1310                 1315                 1320             


Thr Thr  Ala Cys Thr Cys Cys  Ala Gly Gly Ala Gly  Ala Thr Gly 
    1325                 1330                 1335             


Cys Ala  Cys Gly Thr Thr Thr  Cys Cys Cys Ala Thr  Thr Thr Cys 
    1340                 1345                 1350             


Cys Ala  Cys Thr Thr Cys Thr  Cys Cys Cys Thr Gly  Gly Ala Cys 
    1355                 1360                 1365             


Thr Gly  Gly Gly Cys Cys Cys  Thr Gly Ala Thr Cys  Cys Thr Gly 
    1370                 1375                 1380             


Cys Cys  Gly Cys Thr Gly Gly  Gly Cys Ala Ala Cys  Cys Ala Gly 
    1385                 1390                 1395             


Thr Cys  Cys Cys Ala Gly Gly  Thr Gly Ala Ala Cys  Cys Ala Cys 
    1400                 1405                 1410             


Ala Cys  Gly Gly Thr Cys Cys  Thr Cys Gly Ala Cys  Thr Ala Cys 
    1415                 1420                 1425             


Thr Ala  Cys Cys Gly Cys Thr  Gly Cys Gly Thr Gly  Gly Thr Cys 
    1430                 1435                 1440             


Ala Gly  Cys Gly Ala Gly Cys  Thr Cys Gly Thr Gly  Cys Gly Cys 
    1445                 1450                 1455             


Gly Cys  Cys Ala Ala Cys Ala  Thr Cys Ala Cys Cys  Cys Cys Gly 
    1460                 1465                 1470             


Gly Thr  Gly Gly Thr Gly Gly  Cys Gly Cys Thr Cys  Thr Gly Gly 
    1475                 1480                 1485             


Cys Gly  Ala Cys Cys Cys Gly  Cys Gly Gly Cys Cys  Cys Cys Gly 
    1490                 1495                 1500             


Cys Ala  Cys Cys Ala Ala Gly  Gly Gly Cys Thr Gly  Cys Cys Gly 
    1505                 1510                 1515             


Cys Gly  Gly Cys Cys Cys Cys  Thr Gly Gly Cys Cys  Ala Ala Gly 
    1520                 1525                 1530             


Cys Ala  Cys Gly Gly Ala Gly  Cys Cys Thr Gly Gly  Gly Ala Gly 
    1535                 1540                 1545             


Ala Ala  Cys Cys Cys Ala Cys  Ala Cys Ala Cys Cys  Gly Cys Cys 
    1550                 1555                 1560             


Thr Cys  Gly Gly Cys Thr Thr  Thr Thr Gly Cys Ala  Gly Ala Gly 
    1565                 1570                 1575             


Thr Ala  Cys Gly Cys Cys Cys  Gly Gly Cys Thr Gly  Thr Gly Cys 
    1580                 1585                 1590             


Thr Thr  Cys Ala Ala Gly Gly  Ala Thr Cys Thr Cys  Gly Gly Cys 
    1595                 1600                 1605             


Cys Ala  Cys Cys Ala Cys Gly  Thr Cys Ala Ala Gly  Thr Thr Cys 
    1610                 1615                 1620             


Thr Gly  Gly Ala Thr Cys Ala  Cys Gly Ala Thr Gly  Gly Gly Cys 
    1625                 1630                 1635             


Gly Ala  Gly Cys Cys Gly Thr  Ala Cys Ala Cys Ala  Cys Gly Gly 
    1640                 1645                 1650             


Ala Ala  Cys Ala Thr Gly Ala  Cys Cys Thr Ala Cys  Ala Gly Cys 
    1655                 1660                 1665             


Gly Cys  Gly Gly Gly Gly Cys  Ala Cys Ala Ala Thr  Cys Thr Thr 
    1670                 1675                 1680             


Cys Thr  Gly Ala Ala Gly Gly  Cys Thr Cys Ala Cys  Gly Cys Gly 
    1685                 1690                 1695             


Thr Thr  Gly Gly Cys Cys Thr  Gly Gly Cys Gly Cys  Gly Thr Gly 
    1700                 1705                 1710             


Thr Ala  Cys Gly Ala Thr Gly  Ala Ala Ala Ala Cys  Thr Thr Thr 
    1715                 1720                 1725             


Cys Gly  Gly Gly Gly Cys Thr  Cys Thr Cys Ala Gly  Ala Ala Gly 
    1730                 1735                 1740             


Gly Gly  Gly Ala Ala Ala Ala  Thr Ala Thr Cys Cys  Ala Thr Ala 
    1745                 1750                 1755             


Gly Cys  Cys Cys Thr Gly Cys  Ala Gly Gly Cys Cys  Gly Ala Cys 
    1760                 1765                 1770             


Thr Gly  Gly Ala Thr Ala Gly  Ala Gly Cys Cys Gly  Gly Cys Cys 
    1775                 1780                 1785             


Thr Gly  Cys Cys Cys Thr Thr  Thr Cys Thr Cys Cys  Cys Ala Ala 
    1790                 1795                 1800             


Ala Ala  Gly Gly Ala Cys Ala  Ala Ala Gly Ala Ala  Gly Thr Gly 
    1805                 1810                 1815             


Gly Cys  Ala Gly Ala Gly Ala  Gly Ala Gly Thr Thr  Thr Thr Gly 
    1820                 1825                 1830             


Gly Ala  Ala Thr Thr Thr Gly  Ala Cys Ala Thr Thr  Gly Gly Cys 
    1835                 1840                 1845             


Thr Gly  Gly Cys Thr Gly Gly  Cys Cys Gly Ala Gly  Cys Cys Cys 
    1850                 1855                 1860             


Ala Thr  Thr Thr Thr Cys Gly  Gly Cys Thr Cys Thr  Gly Gly Gly 
    1865                 1870                 1875             


Gly Ala  Thr Thr Ala Thr Cys  Cys Gly Cys Gly Thr  Gly Thr Gly 
    1880                 1885                 1890             


Ala Thr  Gly Ala Gly Gly Gly  Ala Cys Thr Gly Gly  Cys Thr Cys 
    1895                 1900                 1905             


Ala Cys  Gly Cys Ala Gly Ala  Gly Ala Ala Ala Cys  Ala Ala Thr 
    1910                 1915                 1920             


Thr Thr  Cys Cys Thr Thr Cys  Thr Ala Cys Cys Thr  Thr Ala Thr 
    1925                 1930                 1935             


Thr Thr  Cys Ala Cys Thr Gly  Ala Ala Gly Ala Thr  Gly Ala Ala 
    1940                 1945                 1950             


Ala Ala  Ala Ala Ala Gly Cys  Thr Ala Ala Thr Cys  Cys Gly Gly 
    1955                 1960                 1965             


Gly Gly  Thr Thr Cys Cys Thr  Thr Cys Gly Ala Cys  Thr Thr Thr 
    1970                 1975                 1980             


Cys Thr  Gly Gly Cys Cys Gly  Thr Ala Ala Gly Cys  Cys Ala Thr 
    1985                 1990                 1995             


Thr Ala  Cys Ala Cys Cys Ala  Cys Cys Ala Thr Cys  Cys Thr Cys 
    2000                 2005                 2010             


Gly Thr  Cys Gly Ala Cys Thr  Gly Gly Gly Ala Ala  Ala Ala Ala 
    2015                 2020                 2025             


Gly Ala  Ala Gly Ala Thr Cys  Cys Ala Ala Thr Gly  Ala Ala Ala 
    2030                 2035                 2040             


Thr Ala  Cys Ala Ala Cys Gly  Ala Thr Thr Ala Cys  Cys Thr Gly 
    2045                 2050                 2055             


Gly Ala  Gly Gly Thr Gly Cys  Ala Gly Gly Ala Ala  Ala Thr Gly 
    2060                 2065                 2070             


Ala Cys  Cys Gly Ala Cys Ala  Thr Cys Ala Cys Gly  Thr Gly Gly 
    2075                 2080                 2085             


Cys Thr  Cys Ala Ala Cys Thr  Cys Cys Cys Cys Cys  Ala Gly Thr 
    2090                 2095                 2100             


Cys Ala  Gly Gly Thr Gly Gly  Cys Ala Gly Thr Ala  Gly Thr Gly 
    2105                 2110                 2115             


Cys Cys  Cys Thr Gly Gly Gly  Gly Cys Thr Thr Ala  Cys Gly Cys 
    2120                 2125                 2130             


Ala Ala  Ala Ala Thr Thr Cys  Thr Cys Ala Ala Cys  Thr Gly Gly 
    2135                 2140                 2145             


Cys Thr  Gly Ala Ala Gly Cys  Thr Gly Ala Ala Gly  Thr Ala Cys 
    2150                 2155                 2160             


Gly Gly  Ala Gly Ala Cys Cys  Thr Cys Cys Cys Cys  Ala Thr Gly 
    2165                 2170                 2175             


Thr Ala  Thr Ala Thr Ala Ala  Thr Ala Thr Cys Cys  Ala Ala Cys 
    2180                 2185                 2190             


Gly Gly  Cys Ala Thr Ala Gly  Ala Cys Gly Ala Cys  Gly Ala Thr 
    2195                 2200                 2205             


Cys Cys  Gly Cys Ala Gly Gly  Cys Ala Gly Cys Gly  Cys Ala Ala 
    2210                 2215                 2220             


Gly Ala  Cys Ala Ala Gly Cys  Thr Gly Ala Gly Gly  Gly Thr Gly 
    2225                 2230                 2235             


Thr Ala  Thr Thr Ala Cys Ala  Thr Gly Cys Ala Ala  Ala Ala Thr 
    2240                 2245                 2250             


Thr Ala  Thr Gly Thr Ala Ala  Ala Thr Gly Ala Ala  Gly Cys Thr 
    2255                 2260                 2265             


Cys Thr  Gly Ala Ala Ala Gly  Cys Cys Thr Ala Cys  Gly Thr Ala 
    2270                 2275                 2280             


Thr Thr  Gly Gly Ala Thr Gly  Gly Thr Gly Thr Cys  Ala Ala Thr 
    2285                 2290                 2295             


Cys Thr  Thr Thr Gly Thr Gly  Gly Ala Thr Ala Cys  Thr Thr Thr 
    2300                 2305                 2310             


Gly Cys  Thr Thr Ala Thr Thr  Cys Ala Thr Thr Cys  Ala Ala Thr 
    2315                 2320                 2325             


Gly Ala  Thr Cys Gly Cys Ala  Cys Ala Gly Cys Thr  Cys Cys Ala 
    2330                 2335                 2340             


Ala Ala  Gly Thr Thr Thr Gly  Gly Cys Thr Thr Cys  Thr Ala Thr 
    2345                 2350                 2355             


Cys Ala  Thr Thr Ala Cys Gly  Cys Thr Gly Cys Ala  Ala Ala Thr 
    2360                 2365                 2370             


Cys Ala  Gly Thr Thr Thr Gly  Ala Gly Cys Cys Cys  Ala Ala Ala 
    2375                 2380                 2385             


Cys Cys  Gly Thr Cys Cys Ala  Thr Gly Ala Ala Ala  Cys Ala Thr 
    2390                 2395                 2400             


Thr Ala  Thr Cys Gly Gly Ala  Ala Ala Ala Thr Gly  Ala Thr Thr 
    2405                 2410                 2415             


Gly Ala  Cys Ala Gly Cys Ala  Ala Thr Gly Gly Cys  Thr Thr Cys 
    2420                 2425                 2430             


Thr Cys  Cys Gly Gly Thr Cys  Cys Thr Gly Ala Cys  Ala Cys Thr 
    2435                 2440                 2445             


Cys Thr  Gly Gly Gly Gly Ala  Gly Ala Thr Thr Thr  Thr Gly Thr 
    2450                 2455                 2460             


Cys Cys  Ala Gly Ala Ala Gly  Ala Ala Thr Thr Cys  Ala Cys Cys 
    2465                 2470                 2475             


Cys Thr  Gly Thr Gly Cys Ala  Cys Cys Gly Ala Ala  Thr Gly Cys 
    2480                 2485                 2490             


Gly Gly  Cys Thr Thr Thr Thr  Thr Thr Cys Ala Cys  Ala Cys Cys 
    2495                 2500                 2505             


Cys Gly  Cys Ala Ala Ala Thr  Cys Thr Thr Thr Ala  Cys Thr Gly 
    2510                 2515                 2520             


Gly Cys  Thr Thr Thr Cys Ala  Thr Ala Gly Cys Thr  Thr Thr Cys 
    2525                 2530                 2535             


Cys Thr  Ala Cys Thr Thr Thr  Thr Thr Gly Cys Thr  Thr Thr Thr 
    2540                 2545                 2550             


Ala Thr  Thr Ala Thr Thr Thr  Cys Thr Cys Thr Thr  Thr Cys Thr 
    2555                 2560                 2565             


Cys Thr  Gly Ala Thr Thr Thr  Thr Thr Thr Ala Cys  Thr Ala Cys 
    2570                 2575                 2580             


Thr Cys  Thr Ala Ala Gly Ala  Ala Ala Gly Gly Cys  Ala Ala Ala 
    2585                 2590                 2595             


Ala Gly  Ala Ala Gly Thr Thr  Ala Cys Ala Ala Gly  Thr Ala Gly 
    2600                 2605                 2610             


Thr Cys  Cys Thr Gly Ala Cys  Cys Thr Thr Thr Thr  Thr Cys Cys 
    2615                 2620                 2625             


Thr Ala  Thr Thr Cys Ala Thr  Thr Thr Ala Cys Thr  Thr Thr Gly 
    2630                 2635                 2640             


Ala Ala  Ala Thr Gly Ala Thr  Thr Ala Thr Gly Cys  Ala Cys Ala 
    2645                 2650                 2655             


Cys Ala  Cys Ala Thr Cys Ala  Gly Cys Thr Gly Thr  Thr Cys Ala 
    2660                 2665                 2670             


Cys Cys  Ala Thr Thr Thr Gly  Cys Ala Cys Thr Thr  Cys Thr Cys 
    2675                 2680                 2685             


Ala Gly  Thr Gly Thr Cys Gly  Thr Ala Ala Gly Ala  Cys Thr Gly 
    2690                 2695                 2700             


Gly Ala  Thr Thr Thr Cys Ala  Cys Thr Thr Ala Thr  Cys Thr Gly 
    2705                 2710                 2715             


Ala Cys  Thr Thr Cys Thr Ala  Gly Ala Ala Ala Ala  Ala Ala Ala 
    2720                 2725                 2730             


Ala Thr  Gly Thr Gly Thr Gly  Gly Cys Gly Thr Ala  Thr Gly Ala 
    2735                 2740                 2745             


Cys Ala  Gly Ala Gly Gly Thr  Ala Thr Gly Gly Ala  Ala Gly Thr 
    2750                 2755                 2760             


Gly Ala  Gly Cys Ala Thr Ala  Gly Gly Thr Gly Ala  Thr Thr Gly 
    2765                 2770                 2775             


Thr Ala  Ala Ala Ala Thr Ala  Cys Thr Gly Ala Ala  Thr Ala Ala 
    2780                 2785                 2790             


Thr Gly  Thr Gly Ala Ala Thr  Ala Gly Thr Gly Cys  Cys Thr Gly 
    2795                 2800                 2805             


Gly Ala  Thr Thr Thr Gly Thr  Thr Cys Thr Thr Thr  Cys Thr Thr 
    2810                 2815                 2820             


Gly Gly  Ala Gly Gly Ala Thr  Gly Ala Thr Cys Ala  Ala Ala Gly 
    2825                 2830                 2835             


Ala Cys  Gly Gly Thr Thr Ala  Gly Gly Gly Gly Cys  Cys Ala Thr 
    2840                 2845                 2850             


Cys Ala  Thr Cys Thr Cys Thr  Gly Cys Ala Ala Cys  Ala Cys Ala 
    2855                 2860                 2865             


Thr Thr  Cys Thr Gly Thr Ala  Ala Cys Ala Ala Ala  Thr Gly Thr 
    2870                 2875                 2880             


Ala Thr  Gly Gly Gly Ala Ala  Gly Thr Gly Gly Gly  Ala Cys Cys 
    2885                 2890                 2895             


Cys Ala  Thr Thr Cys Thr Gly  Gly Ala Ala Cys Ala  Thr Thr Thr 
    2900                 2905                 2910             


Thr Thr  Ala Thr Ala Gly Ala  Ala Ala Thr Thr Gly  Ala Ala Thr 
    2915                 2920                 2925             


Ala Gly  Cys Ala Ala Gly Ala  Thr Cys Ala Gly Thr  Gly Cys Cys 
    2930                 2935                 2940             


Cys Gly  Thr Thr Cys Cys Thr  Ala Ala Ala Thr Thr  Ala Thr Cys 
    2945                 2950                 2955             


Thr Thr  Gly Ala Ala Gly Thr  Ala Ala Ala Ala Cys  Ala Ala Ala 
    2960                 2965                 2970             


Thr Gly  Thr Gly Gly Ala Ala  Ala Thr Ala Ala Ala  Ala Ala Gly 
    2975                 2980                 2985             


Thr Thr  Ala Ala Gly Thr Cys  Cys Cys Ala Ala Ala  Thr Ala Ala 
    2990                 2995                 3000             


Cys Cys  Ala Thr Cys Thr Cys  Thr Ala Ala Ala Cys  Thr Thr Cys 
    3005                 3010                 3015             


Cys Ala  Thr Gly Ala Thr Ala  Thr Gly Cys Cys Thr  Ala Ala Thr 
    3020                 3025                 3030             


Gly Gly  Thr Cys Thr Cys Thr  Gly Thr Thr Gly Gly  Ala Cys Cys 
    3035                 3040                 3045             


Cys Ala  Gly Thr Thr Thr Cys  Cys Cys Thr Thr Gly  Ala Ala Ala 
    3050                 3055                 3060             


Ala Ala  Gly Ala Ala Ala Thr  Gly Gly Thr Ala Gly  Ala Ala Thr 
    3065                 3070                 3075             


Ala Thr  Thr Ala Gly Ala Gly  Ala Cys Ala Thr Gly  Ala Cys Ala 
    3080                 3085                 3090             


Gly Ala  Gly Gly Gly Cys Cys  Cys Thr Ala Cys Gly  Cys Thr Ala 
    3095                 3100                 3105             


Gly Ala  Ala Cys Gly Thr Thr  Cys Cys Thr Thr Thr  Thr Ala Thr 
    3110                 3115                 3120             


Thr Thr  Thr Thr Thr Thr Thr  Thr Thr Thr Ala Ala  Ala Thr Thr 
    3125                 3130                 3135             


Thr Thr  Thr Thr Thr Thr Cys  Ala Ala Thr Gly Thr  Thr Thr Thr 
    3140                 3145                 3150             


Thr Ala  Thr Thr Thr Ala Thr  Thr Thr Thr Thr Gly  Gly Gly Ala 
    3155                 3160                 3165             


Cys Ala  Gly Ala Gly Ala Gly  Ala Gly Ala 
    3170                 3175             


<210>  124
<211>  2968
<212>  PRT
<213>  Felis catus

<400>  124

Thr Cys Thr Thr Thr Cys Thr Gly Gly Ala Thr Thr Gly Cys Thr Cys 
1               5                   10                  15      


Cys Gly Thr Cys Ala Thr Gly Ala Gly Ala Ala Cys Cys Gly Gly Thr 
            20                  25                  30          


Gly Thr Cys Ala Gly Cys Ala Cys Gly Thr Gly Gly Gly Cys Thr Gly 
        35                  40                  45              


Gly Thr Thr Thr Ala Cys Thr Gly Ala Ala Ala Gly Gly Thr Gly Ala 
    50                  55                  60                  


Ala Gly Ala Cys Ala Gly Ala Cys Thr Thr Thr Gly Gly Ala Ala Gly 
65                  70                  75                  80  


Ala Thr Cys Ala Ala Ala Gly Ala Thr Cys Ala Cys Cys Cys Thr Gly 
                85                  90                  95      


Gly Ala Thr Gly Thr Thr Cys Thr Cys Gly Cys Cys Ala Cys Cys Gly 
            100                 105                 110         


Gly Thr Gly Ala Gly Ala Thr Cys Cys Cys Ala Gly Cys Thr Gly Ala 
        115                 120                 125             


Gly Thr Gly Cys Ala Gly Cys Thr Ala Thr Ala Thr Gly Cys Gly Thr 
    130                 135                 140                 


Gly Ala Cys Cys Thr Cys Thr Gly Cys Thr Ala Cys Ala Thr Cys Ala 
145                 150                 155                 160 


Cys Ala Thr Gly Gly Ala Gly Cys Ala Gly Ala Gly Gly Ala Ala Cys 
                165                 170                 175     


Thr Gly Thr Cys Cys Ala Gly Gly Cys Thr Cys Ala Thr Gly Cys Cys 
            180                 185                 190         


Ala Ala Ala Ala Thr Cys Thr Gly Gly Cys Ala Thr Cys Thr Cys Thr 
        195                 200                 205             


Ala Cys Ala Ala Thr Ala Cys Thr Thr Cys Thr Thr Thr Cys Cys Gly 
    210                 215                 220                 


Thr Cys Cys Ala Ala Cys Thr Cys Ala Gly Gly Gly Ala Gly Gly Cys 
225                 230                 235                 240 


Cys Ala Gly Gly Thr Cys Thr Cys Cys Ala Thr Cys Gly Cys Cys Cys 
                245                 250                 255     


Thr Ala Ala Gly Cys Thr Cys Cys Cys Ala Cys Thr Gly Gly Ala Thr 
            260                 265                 270         


Cys Ala Ala Thr Cys Cys Thr Cys Gly Ala Ala Gly Ala Ala Thr Gly 
        275                 280                 285             


Ala Cys Cys Gly Ala Cys Cys Ala Cys Ala Gly Cys Ala Thr Cys Ala 
    290                 295                 300                 


Ala Ala Gly Ala Ala Thr Gly Thr Cys Ala Ala Ala Ala Gly Thr Cys 
305                 310                 315                 320 


Thr Cys Thr Thr Gly Ala Cys Thr Thr Thr Gly Thr Ala Cys Thr Ala 
                325                 330                 335     


Gly Gly Cys Thr Gly Gly Thr Thr Thr Gly Cys Cys Ala Ala Ala Cys 
            340                 345                 350         


Cys Cys Ala Thr Ala Thr Thr Thr Ala Thr Thr Gly Ala Thr Gly Gly 
        355                 360                 365             


Thr Gly Ala Cys Thr Ala Thr Cys Cys Thr Gly Ala Gly Ala Gly Cys 
    370                 375                 380                 


Ala Thr Gly Ala Ala Gly Ala Ala Thr Ala Ala Thr Cys Thr Thr Thr 
385                 390                 395                 400 


Cys Ala Cys Ala Thr Cys Thr Thr Cys Thr Gly Cys Cys Thr Gly Ala 
                405                 410                 415     


Thr Thr Thr Thr Ala Cys Thr Gly Ala Ala Gly Cys Thr Gly Ala Gly 
            420                 425                 430         


Ala Ala Ala Ala Ala Gly Thr Thr Cys Ala Thr Thr Ala Ala Gly Gly 
        435                 440                 445             


Gly Ala Ala Cys Ala Gly Cys Thr Gly Ala Cys Thr Thr Thr Thr Thr 
    450                 455                 460                 


Thr Gly Cys Thr Cys Thr Thr Thr Cys Thr Thr Thr Thr Gly Gly Ala 
465                 470                 475                 480 


Cys Cys Ala Ala Cys Cys Thr Thr Gly Ala Gly Thr Thr Thr Thr Cys 
                485                 490                 495     


Ala Ala Cys Thr Ala Thr Thr Gly Gly Ala Cys Cys Cys Cys Cys Ala 
            500                 505                 510         


Cys Ala Thr Gly Ala Ala Gly Thr Thr Cys Cys Gly Cys Cys Ala Gly 
        515                 520                 525             


Thr Thr Ala Gly Ala Ala Thr Cys Thr Cys Cys Cys Ala Gly Cys Cys 
    530                 535                 540                 


Thr Gly Ala Gly Gly Cys Ala Ala Cys Thr Cys Cys Thr Thr Thr Cys 
545                 550                 555                 560 


Thr Thr Gly Gly Ala Thr Thr Gly Ala Cys Cys Thr Thr Gly Ala Ala 
                565                 570                 575     


Thr Ala Thr Ala Ala Cys Cys Ala Cys Cys Cys Thr Cys Ala Ala Ala 
            580                 585                 590         


Thr Ala Thr Thr Thr Ala Thr Thr Gly Thr Gly Gly Ala Ala Ala Ala 
        595                 600                 605             


Thr Gly Gly Cys Thr Gly Gly Thr Thr Thr Gly Thr Cys Thr Cys Ala 
    610                 615                 620                 


Gly Gly Gly Ala Cys Cys Ala Cys Cys Ala Ala Gly Ala Gly Ala Gly 
625                 630                 635                 640 


Ala Cys Gly Ala Cys Gly Cys Cys Ala Ala Ala Thr Ala Thr Ala Thr 
                645                 650                 655     


Gly Thr Ala Thr Thr Ala Cys Cys Thr Cys Ala Ala Ala Ala Ala Ala 
            660                 665                 670         


Thr Thr Cys Gly Thr Ala Ala Thr Gly Gly Ala Ala Ala Cys Cys Thr 
        675                 680                 685             


Thr Ala Ala Ala Ala Gly Cys Cys Ala Thr Thr Ala Gly Gly Cys Thr 
    690                 695                 700                 


Gly Gly Ala Thr Gly Gly Gly Gly Thr Gly Gly Ala Cys Gly Thr Cys 
705                 710                 715                 720 


Ala Thr Thr Gly Gly Gly Thr Ala Cys Ala Cys Gly Gly Cys Cys Thr 
                725                 730                 735     


Gly Gly Thr Cys Cys Cys Thr Thr Ala Thr Gly Gly Ala Thr Gly Gly 
            740                 745                 750         


Cys Thr Thr Cys Gly Ala Ala Thr Gly Gly Cys Ala Cys Ala Gly Ala 
        755                 760                 765             


Gly Gly Thr Thr Ala Cys Ala Gly Cys Ala Thr Cys Ala Gly Gly Cys 
    770                 775                 780                 


Gly Thr Gly Gly Ala Cys Thr Cys Thr Thr Cys Thr Ala Thr Gly Thr 
785                 790                 795                 800 


Thr Gly Ala Cys Thr Thr Thr Cys Thr Ala Ala Gly Cys Cys Ala Gly 
                805                 810                 815     


Gly Ala Thr Ala Ala Gly Ala Ala Ala Cys Thr Gly Thr Thr Gly Cys 
            820                 825                 830         


Cys Gly Ala Ala Ala Thr Cys Thr Thr Cys Ala Gly Cys Cys Thr Thr 
        835                 840                 845             


Gly Thr Thr Cys Thr Ala Cys Cys Ala Ala Ala Ala Gly Cys Thr Gly 
    850                 855                 860                 


Ala Thr Ala Gly Ala Gly Ala Ala Ala Ala Ala Thr Gly Gly Cys Thr 
865                 870                 875                 880 


Thr Cys Cys Cys Thr Cys Cys Thr Thr Thr Ala Cys Cys Thr Gly Ala 
                885                 890                 895     


Ala Ala Ala Thr Cys Ala Ala Cys Cys Thr Cys Thr Ala Gly Ala Ala 
            900                 905                 910         


Gly Gly Gly Ala Cys Ala Thr Thr Thr Cys Cys Cys Thr Gly Thr Gly 
        915                 920                 925             


Ala Cys Thr Thr Thr Gly Cys Thr Thr Gly Gly Gly Gly Ala Ala Thr 
    930                 935                 940                 


Thr Gly Thr Thr Gly Ala Cys Ala Ala Cys Thr Ala Cys Ala Thr Thr 
945                 950                 955                 960 


Cys Ala Ala Gly Thr Gly Gly Ala Cys Ala Cys Cys Ala Cys Thr Cys 
                965                 970                 975     


Thr Gly Thr Cys Thr Cys Ala Gly Thr Thr Thr Ala Cys Cys Gly Ala 
            980                 985                 990         


Cys Cys Cys Gly Ala Ala Cys Gly  Thr Thr Thr Ala Cys  Cys Thr Gly 
        995                 1000                 1005             


Thr Gly  Gly Gly Ala Cys Gly  Thr Cys Cys Ala Cys  Cys Ala Cys 
    1010                 1015                 1020             


Ala Gly  Thr Ala Ala Gly Ala  Gly Gly Cys Thr Ala  Ala Thr Thr 
    1025                 1030                 1035             


Ala Ala  Gly Gly Thr Gly Gly  Ala Cys Gly Gly Gly  Gly Thr Thr 
    1040                 1045                 1050             


Gly Thr  Gly Ala Cys Cys Ala  Ala Gly Ala Ala Gly  Cys Gly Gly 
    1055                 1060                 1065             


Ala Ala  Gly Thr Cys Cys Thr  Ala Cys Thr Gly Cys  Gly Thr Gly 
    1070                 1075                 1080             


Gly Ala  Cys Thr Thr Cys Gly  Cys Thr Gly Cys Cys  Ala Thr Cys 
    1085                 1090                 1095             


Cys Gly  Gly Cys Cys Cys Cys  Ala Gly Ala Thr Ala  Gly Cys Cys 
    1100                 1105                 1110             


Thr Thr  Ala Cys Thr Cys Cys  Ala Gly Gly Ala Gly  Ala Thr Gly 
    1115                 1120                 1125             


Cys Ala  Cys Gly Thr Thr Thr  Cys Cys Cys Ala Thr  Thr Thr Cys 
    1130                 1135                 1140             


Cys Ala  Cys Thr Thr Cys Thr  Cys Cys Cys Thr Gly  Gly Ala Cys 
    1145                 1150                 1155             


Thr Gly  Gly Gly Cys Cys Cys  Thr Gly Ala Thr Cys  Cys Thr Gly 
    1160                 1165                 1170             


Cys Cys  Gly Cys Thr Gly Gly  Gly Cys Ala Ala Cys  Cys Ala Gly 
    1175                 1180                 1185             


Thr Cys  Cys Cys Ala Gly Gly  Thr Gly Ala Ala Cys  Cys Ala Cys 
    1190                 1195                 1200             


Ala Cys  Gly Gly Thr Cys Cys  Thr Cys Gly Ala Cys  Thr Ala Cys 
    1205                 1210                 1215             


Thr Ala  Cys Cys Gly Cys Thr  Gly Cys Gly Thr Gly  Gly Thr Cys 
    1220                 1225                 1230             


Ala Gly  Cys Gly Ala Gly Cys  Thr Cys Gly Thr Gly  Cys Gly Cys 
    1235                 1240                 1245             


Gly Cys  Cys Ala Ala Cys Ala  Thr Cys Ala Cys Cys  Cys Cys Gly 
    1250                 1255                 1260             


Gly Thr  Gly Gly Thr Gly Gly  Cys Gly Cys Thr Cys  Thr Gly Gly 
    1265                 1270                 1275             


Cys Gly  Ala Cys Cys Cys Gly  Cys Gly Gly Cys Cys  Cys Cys Gly 
    1280                 1285                 1290             


Cys Ala  Cys Cys Ala Ala Gly  Gly Gly Cys Thr Gly  Cys Cys Gly 
    1295                 1300                 1305             


Cys Gly  Gly Cys Cys Cys Cys  Thr Gly Gly Cys Cys  Ala Ala Gly 
    1310                 1315                 1320             


Cys Ala  Cys Gly Gly Ala Gly  Cys Cys Thr Gly Gly  Gly Ala Gly 
    1325                 1330                 1335             


Ala Ala  Cys Cys Cys Ala Cys  Ala Cys Ala Cys Cys  Gly Cys Cys 
    1340                 1345                 1350             


Thr Cys  Gly Gly Cys Thr Thr  Thr Thr Gly Cys Ala  Gly Ala Gly 
    1355                 1360                 1365             


Thr Ala  Cys Gly Cys Cys Cys  Gly Gly Cys Thr Gly  Thr Gly Cys 
    1370                 1375                 1380             


Thr Thr  Cys Ala Ala Gly Gly  Ala Thr Cys Thr Cys  Gly Gly Cys 
    1385                 1390                 1395             


Cys Ala  Cys Cys Ala Cys Gly  Thr Cys Ala Ala Gly  Thr Thr Cys 
    1400                 1405                 1410             


Thr Gly  Gly Ala Thr Cys Ala  Cys Gly Ala Thr Gly  Gly Gly Cys 
    1415                 1420                 1425             


Gly Ala  Gly Cys Cys Gly Thr  Ala Cys Ala Cys Ala  Cys Gly Gly 
    1430                 1435                 1440             


Ala Ala  Cys Ala Thr Gly Ala  Cys Cys Thr Ala Cys  Ala Gly Cys 
    1445                 1450                 1455             


Gly Cys  Gly Gly Gly Gly Cys  Ala Cys Ala Ala Thr  Cys Thr Thr 
    1460                 1465                 1470             


Cys Thr  Gly Ala Ala Gly Gly  Cys Thr Cys Ala Cys  Gly Cys Gly 
    1475                 1480                 1485             


Thr Thr  Gly Gly Cys Cys Thr  Gly Gly Cys Gly Cys  Gly Thr Gly 
    1490                 1495                 1500             


Thr Ala  Cys Gly Ala Thr Gly  Ala Ala Ala Ala Cys  Thr Thr Thr 
    1505                 1510                 1515             


Cys Gly  Gly Gly Gly Cys Thr  Cys Thr Cys Ala Gly  Ala Ala Gly 
    1520                 1525                 1530             


Gly Gly  Gly Ala Ala Ala Ala  Thr Ala Thr Cys Cys  Ala Thr Ala 
    1535                 1540                 1545             


Gly Cys  Cys Cys Thr Gly Cys  Ala Gly Gly Cys Cys  Gly Ala Cys 
    1550                 1555                 1560             


Thr Gly  Gly Ala Thr Ala Gly  Ala Gly Cys Cys Gly  Gly Cys Cys 
    1565                 1570                 1575             


Thr Gly  Cys Cys Cys Thr Thr  Thr Cys Thr Cys Cys  Cys Ala Ala 
    1580                 1585                 1590             


Ala Ala  Gly Gly Ala Cys Ala  Ala Ala Gly Ala Ala  Gly Thr Gly 
    1595                 1600                 1605             


Gly Cys  Ala Gly Ala Gly Ala  Gly Ala Gly Thr Thr  Thr Thr Gly 
    1610                 1615                 1620             


Gly Ala  Ala Thr Thr Thr Gly  Ala Cys Ala Thr Thr  Gly Gly Cys 
    1625                 1630                 1635             


Thr Gly  Gly Cys Thr Gly Gly  Cys Cys Gly Ala Gly  Cys Cys Cys 
    1640                 1645                 1650             


Ala Thr  Thr Thr Thr Cys Gly  Gly Cys Thr Cys Thr  Gly Gly Gly 
    1655                 1660                 1665             


Gly Ala  Thr Thr Ala Thr Cys  Cys Gly Cys Gly Thr  Gly Thr Gly 
    1670                 1675                 1680             


Ala Thr  Gly Ala Gly Gly Gly  Ala Cys Thr Gly Gly  Cys Thr Cys 
    1685                 1690                 1695             


Ala Cys  Gly Cys Ala Gly Ala  Gly Ala Ala Ala Cys  Ala Ala Thr 
    1700                 1705                 1710             


Thr Thr  Cys Cys Thr Thr Cys  Thr Ala Cys Cys Thr  Thr Ala Thr 
    1715                 1720                 1725             


Thr Thr  Cys Ala Cys Thr Gly  Ala Ala Gly Ala Thr  Gly Ala Ala 
    1730                 1735                 1740             


Ala Ala  Ala Ala Ala Gly Cys  Thr Ala Ala Thr Cys  Cys Gly Gly 
    1745                 1750                 1755             


Gly Gly  Thr Thr Cys Cys Thr  Thr Cys Gly Ala Cys  Thr Thr Thr 
    1760                 1765                 1770             


Cys Thr  Gly Gly Cys Cys Gly  Thr Ala Ala Gly Cys  Cys Ala Thr 
    1775                 1780                 1785             


Thr Ala  Cys Ala Cys Cys Ala  Cys Cys Ala Thr Cys  Cys Thr Cys 
    1790                 1795                 1800             


Gly Thr  Cys Gly Ala Cys Thr  Gly Gly Gly Ala Ala  Ala Ala Ala 
    1805                 1810                 1815             


Gly Ala  Ala Gly Ala Thr Cys  Cys Ala Ala Thr Gly  Ala Ala Ala 
    1820                 1825                 1830             


Thr Ala  Cys Ala Ala Cys Gly  Ala Thr Thr Ala Cys  Cys Thr Gly 
    1835                 1840                 1845             


Gly Ala  Gly Gly Thr Gly Cys  Ala Gly Gly Ala Ala  Ala Thr Gly 
    1850                 1855                 1860             


Ala Cys  Cys Gly Ala Cys Ala  Thr Cys Ala Cys Gly  Thr Gly Gly 
    1865                 1870                 1875             


Cys Thr  Cys Ala Ala Cys Thr  Cys Cys Cys Cys Cys  Ala Gly Thr 
    1880                 1885                 1890             


Cys Ala  Gly Gly Thr Gly Gly  Cys Ala Gly Thr Ala  Gly Thr Gly 
    1895                 1900                 1905             


Cys Cys  Cys Thr Gly Gly Gly  Gly Cys Thr Thr Ala  Cys Gly Cys 
    1910                 1915                 1920             


Ala Ala  Ala Ala Thr Thr Cys  Thr Cys Ala Ala Cys  Thr Gly Gly 
    1925                 1930                 1935             


Cys Thr  Gly Ala Ala Gly Cys  Thr Gly Ala Ala Gly  Thr Ala Cys 
    1940                 1945                 1950             


Gly Gly  Ala Gly Ala Cys Cys  Thr Cys Cys Cys Cys  Ala Thr Gly 
    1955                 1960                 1965             


Thr Ala  Thr Ala Thr Ala Ala  Thr Ala Thr Cys Cys  Ala Ala Cys 
    1970                 1975                 1980             


Gly Gly  Cys Ala Thr Ala Gly  Ala Cys Gly Ala Cys  Gly Ala Thr 
    1985                 1990                 1995             


Cys Cys  Gly Cys Ala Gly Gly  Cys Ala Gly Cys Gly  Cys Ala Ala 
    2000                 2005                 2010             


Gly Ala  Cys Ala Ala Gly Cys  Thr Gly Ala Gly Gly  Gly Thr Gly 
    2015                 2020                 2025             


Thr Ala  Thr Thr Ala Cys Ala  Thr Gly Cys Ala Ala  Ala Ala Thr 
    2030                 2035                 2040             


Thr Ala  Thr Gly Thr Ala Ala  Ala Thr Gly Ala Ala  Gly Cys Thr 
    2045                 2050                 2055             


Cys Thr  Gly Ala Ala Ala Gly  Cys Cys Thr Ala Cys  Gly Thr Ala 
    2060                 2065                 2070             


Thr Thr  Gly Gly Ala Thr Gly  Gly Thr Gly Thr Cys  Ala Ala Thr 
    2075                 2080                 2085             


Cys Thr  Thr Thr Gly Thr Gly  Gly Ala Thr Ala Cys  Thr Thr Thr 
    2090                 2095                 2100             


Gly Cys  Thr Thr Ala Thr Thr  Cys Ala Thr Thr Cys  Ala Ala Thr 
    2105                 2110                 2115             


Gly Ala  Thr Cys Gly Cys Ala  Cys Ala Gly Cys Thr  Cys Cys Ala 
    2120                 2125                 2130             


Ala Ala  Gly Thr Thr Thr Gly  Gly Cys Thr Thr Cys  Thr Ala Thr 
    2135                 2140                 2145             


Cys Ala  Thr Thr Ala Cys Gly  Cys Thr Gly Cys Ala  Ala Ala Thr 
    2150                 2155                 2160             


Cys Ala  Gly Thr Thr Thr Gly  Ala Gly Cys Cys Cys  Ala Ala Ala 
    2165                 2170                 2175             


Cys Cys  Gly Thr Cys Cys Ala  Thr Gly Ala Ala Ala  Cys Ala Thr 
    2180                 2185                 2190             


Thr Ala  Thr Cys Gly Gly Ala  Ala Ala Ala Thr Gly  Ala Thr Thr 
    2195                 2200                 2205             


Gly Ala  Cys Ala Gly Cys Ala  Ala Thr Gly Gly Cys  Thr Thr Cys 
    2210                 2215                 2220             


Thr Cys  Cys Gly Gly Thr Cys  Cys Thr Gly Ala Cys  Ala Cys Thr 
    2225                 2230                 2235             


Cys Thr  Gly Gly Gly Gly Ala  Gly Ala Thr Thr Thr  Thr Gly Thr 
    2240                 2245                 2250             


Cys Cys  Ala Gly Ala Ala Gly  Ala Ala Thr Thr Cys  Ala Cys Cys 
    2255                 2260                 2265             


Cys Thr  Gly Thr Gly Cys Ala  Cys Cys Gly Ala Ala  Thr Gly Cys 
    2270                 2275                 2280             


Gly Gly  Cys Thr Thr Thr Thr  Thr Thr Cys Ala Cys  Ala Cys Cys 
    2285                 2290                 2295             


Cys Gly  Cys Ala Ala Ala Thr  Cys Thr Thr Thr Ala  Cys Thr Gly 
    2300                 2305                 2310             


Gly Cys  Thr Thr Thr Cys Ala  Thr Ala Gly Cys Thr  Thr Thr Cys 
    2315                 2320                 2325             


Cys Thr  Ala Cys Thr Thr Thr  Thr Thr Gly Cys Thr  Thr Thr Thr 
    2330                 2335                 2340             


Ala Thr  Thr Ala Thr Thr Thr  Cys Thr Cys Thr Thr  Thr Cys Thr 
    2345                 2350                 2355             


Cys Thr  Gly Ala Thr Thr Thr  Thr Thr Thr Ala Cys  Thr Ala Cys 
    2360                 2365                 2370             


Thr Cys  Thr Ala Ala Gly Ala  Ala Ala Gly Gly Cys  Ala Ala Ala 
    2375                 2380                 2385             


Ala Gly  Ala Ala Gly Thr Thr  Ala Cys Ala Ala Gly  Thr Ala Gly 
    2390                 2395                 2400             


Thr Cys  Cys Thr Gly Ala Cys  Cys Thr Thr Thr Thr  Thr Cys Cys 
    2405                 2410                 2415             


Thr Ala  Thr Thr Cys Ala Thr  Thr Thr Ala Cys Thr  Thr Thr Gly 
    2420                 2425                 2430             


Ala Ala  Ala Thr Gly Ala Thr  Thr Ala Thr Gly Cys  Ala Cys Ala 
    2435                 2440                 2445             


Cys Ala  Cys Ala Thr Cys Ala  Gly Cys Thr Gly Thr  Thr Cys Ala 
    2450                 2455                 2460             


Cys Cys  Ala Thr Thr Thr Gly  Cys Ala Cys Thr Thr  Cys Thr Cys 
    2465                 2470                 2475             


Ala Gly  Thr Gly Thr Cys Gly  Thr Ala Ala Gly Ala  Cys Thr Gly 
    2480                 2485                 2490             


Gly Ala  Thr Thr Thr Cys Ala  Cys Thr Thr Ala Thr  Cys Thr Gly 
    2495                 2500                 2505             


Ala Cys  Thr Thr Cys Thr Ala  Gly Ala Ala Ala Ala  Ala Ala Ala 
    2510                 2515                 2520             


Ala Thr  Gly Thr Gly Thr Gly  Gly Cys Gly Thr Ala  Thr Gly Ala 
    2525                 2530                 2535             


Cys Ala  Gly Ala Gly Gly Thr  Ala Thr Gly Gly Ala  Ala Gly Thr 
    2540                 2545                 2550             


Gly Ala  Gly Cys Ala Thr Ala  Gly Gly Thr Gly Ala  Thr Thr Gly 
    2555                 2560                 2565             


Thr Ala  Ala Ala Ala Thr Ala  Cys Thr Gly Ala Ala  Thr Ala Ala 
    2570                 2575                 2580             


Thr Gly  Thr Gly Ala Ala Thr  Ala Gly Thr Gly Cys  Cys Thr Gly 
    2585                 2590                 2595             


Gly Ala  Thr Thr Thr Gly Thr  Thr Cys Thr Thr Thr  Cys Thr Thr 
    2600                 2605                 2610             


Gly Gly  Ala Gly Gly Ala Thr  Gly Ala Thr Cys Ala  Ala Ala Gly 
    2615                 2620                 2625             


Ala Cys  Gly Gly Thr Thr Ala  Gly Gly Gly Gly Cys  Cys Ala Thr 
    2630                 2635                 2640             


Cys Ala  Thr Cys Thr Cys Thr  Gly Cys Ala Ala Cys  Ala Cys Ala 
    2645                 2650                 2655             


Thr Thr  Cys Thr Gly Thr Ala  Ala Cys Ala Ala Ala  Thr Gly Thr 
    2660                 2665                 2670             


Ala Thr  Gly Gly Gly Ala Ala  Gly Thr Gly Gly Gly  Ala Cys Cys 
    2675                 2680                 2685             


Cys Ala  Thr Thr Cys Thr Gly  Gly Ala Ala Cys Ala  Thr Thr Thr 
    2690                 2695                 2700             


Thr Thr  Ala Thr Ala Gly Ala  Ala Ala Thr Thr Gly  Ala Ala Thr 
    2705                 2710                 2715             


Ala Gly  Cys Ala Ala Gly Ala  Thr Cys Ala Gly Thr  Gly Cys Cys 
    2720                 2725                 2730             


Cys Gly  Thr Thr Cys Cys Thr  Ala Ala Ala Thr Thr  Ala Thr Cys 
    2735                 2740                 2745             


Thr Thr  Gly Ala Ala Gly Thr  Ala Ala Ala Ala Cys  Ala Ala Ala 
    2750                 2755                 2760             


Thr Gly  Thr Gly Gly Ala Ala  Ala Thr Ala Ala Ala  Ala Ala Gly 
    2765                 2770                 2775             


Thr Thr  Ala Ala Gly Thr Cys  Cys Cys Ala Ala Ala  Thr Ala Ala 
    2780                 2785                 2790             


Cys Cys  Ala Thr Cys Thr Cys  Thr Ala Ala Ala Cys  Thr Thr Cys 
    2795                 2800                 2805             


Cys Ala  Thr Gly Ala Thr Ala  Thr Gly Cys Cys Thr  Ala Ala Thr 
    2810                 2815                 2820             


Gly Gly  Thr Cys Thr Cys Thr  Gly Thr Thr Gly Gly  Ala Cys Cys 
    2825                 2830                 2835             


Cys Ala  Gly Thr Thr Thr Cys  Cys Cys Thr Thr Gly  Ala Ala Ala 
    2840                 2845                 2850             


Ala Ala  Gly Ala Ala Ala Thr  Gly Gly Thr Ala Gly  Ala Ala Thr 
    2855                 2860                 2865             


Ala Thr  Thr Ala Gly Ala Gly  Ala Cys Ala Thr Gly  Ala Cys Ala 
    2870                 2875                 2880             


Gly Ala  Gly Gly Gly Cys Cys  Cys Thr Ala Cys Gly  Cys Thr Ala 
    2885                 2890                 2895             


Gly Ala  Ala Cys Gly Thr Thr  Cys Cys Thr Thr Thr  Thr Ala Thr 
    2900                 2905                 2910             


Thr Thr  Thr Thr Thr Thr Thr  Thr Thr Thr Ala Ala  Ala Thr Thr 
    2915                 2920                 2925             


Thr Thr  Thr Thr Thr Thr Cys  Ala Ala Thr Gly Thr  Thr Thr Thr 
    2930                 2935                 2940             


Thr Ala  Thr Thr Thr Ala Thr  Thr Thr Thr Thr Gly  Gly Gly Ala 
    2945                 2950                 2955             


Cys Ala  Gly Ala Gly Ala Gly  Ala Gly Ala 
    2960                 2965             


<210>  125
<211>  1204
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal_ECD_34_981_2xGS_Fc

<400>  125

Met Ala Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Val Ser 
            20                  25                  30          


Arg Pro Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro 
        35                  40                  45              


Asp Gly Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly 
    50                  55                  60                  


Gly Trp Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr 
65                  70                  75                  80  


His His Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro 
                85                  90                  95      


Leu Gly Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser 
            100                 105                 110         


Asp Ser Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu 
        115                 120                 125             


Gly Val Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro 
    130                 135                 140                 


Asn Gly Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg 
145                 150                 155                 160 


Arg Leu Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr 
                165                 170                 175     


Leu Tyr His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly 
            180                 185                 190         


Trp Ala Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu 
        195                 200                 205             


Cys Phe Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp 
    210                 215                 220                 


Asn Pro Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala 
225                 230                 235                 240 


Pro Gly Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn 
                245                 250                 255     


Leu Leu Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe 
            260                 265                 270         


Arg Pro Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp 
        275                 280                 285             


Ile Asn Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys 
    290                 295                 300                 


Ser Leu Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp 
305                 310                 315                 320 


Gly Asp Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro 
                325                 330                 335     


Asp Phe Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe 
            340                 345                 350         


Phe Ala Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro 
        355                 360                 365             


His Met Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu 
    370                 375                 380                 


Ser Trp Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu 
385                 390                 395                 400 


Asn Gly Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr 
                405                 410                 415     


Met Tyr Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys 
            420                 425                 430         


Leu Asp Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp 
        435                 440                 445             


Gly Phe Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr 
    450                 455                 460                 


Val Asp Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala 
465                 470                 475                 480 


Leu Phe Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro 
                485                 490                 495     


Glu Asn Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly 
            500                 505                 510         


Val Val Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr 
        515                 520                 525             


Asp Leu Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile 
    530                 535                 540                 


Lys Val Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp 
545                 550                 555                 560 


Phe Ala Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val 
                565                 570                 575     


Thr His Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly 
            580                 585                 590         


Asn Gln Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met 
        595                 600                 605             


Ala Ser Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp 
    610                 615                 620                 


Gln Pro Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln 
625                 630                 635                 640 


Gly Ala Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala 
                645                 650                 655     


Arg Leu Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr 
            660                 665                 670         


Met Asn Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn 
        675                 680                 685             


Leu Leu Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe 
    690                 695                 700                 


Arg His Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp 
705                 710                 715                 720 


Ile Glu Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu 
                725                 730                 735     


Arg Val Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly 
            740                 745                 750         


Ser Gly Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn 
        755                 760                 765             


Asn Phe Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln 
    770                 775                 780                 


Gly Thr Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val 
785                 790                 795                 800 


Asp Ser Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val 
                805                 810                 815     


Gln Glu Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala 
            820                 825                 830         


Val Val Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys 
        835                 840                 845             


Tyr Gly Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly 
    850                 855                 860                 


Leu His Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr 
865                 870                 875                 880 


Ile Asn Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys 
                885                 890                 895     


Gly Tyr Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly 
            900                 905                 910         


Leu Tyr Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys 
        915                 920                 925             


His Tyr Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr 
    930                 935                 940                 


Leu Glu Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser 
945                 950                 955                 960 


Phe Phe His Thr Arg Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                965                 970                 975     


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            980                 985                 990         


Gly Gly Pro Ser Val Phe Leu Phe  Pro Pro Lys Pro Lys  Asp Thr Leu 
        995                 1000                 1005             


Met Ile  Ser Arg Thr Pro Glu  Val Thr Cys Val Val  Val Asp Val 
    1010                 1015                 1020             


Ser His  Glu Asp Pro Glu Val  Lys Phe Asn Trp Tyr  Val Asp Gly 
    1025                 1030                 1035             


Val Glu  Val His Asn Ala Lys  Thr Lys Pro Arg Glu  Glu Gln Tyr 
    1040                 1045                 1050             


Asn Ser  Thr Tyr Arg Val Val  Ser Val Leu Thr Val  Leu His Gln 
    1055                 1060                 1065             


Asp Trp  Leu Asn Gly Lys Glu  Tyr Lys Cys Lys Val  Ser Asn Lys 
    1070                 1075                 1080             


Ala Leu  Pro Ala Pro Ile Glu  Lys Thr Ile Ser Lys  Ala Lys Gly 
    1085                 1090                 1095             


Gln Pro  Arg Glu Pro Gln Val  Tyr Thr Leu Pro Pro  Ser Arg Asp 
    1100                 1105                 1110             


Glu Leu  Thr Lys Asn Gln Val  Ser Leu Thr Cys Leu  Val Lys Gly 
    1115                 1120                 1125             


Phe Tyr  Pro Ser Asp Ile Ala  Val Glu Trp Glu Ser  Asn Gly Gln 
    1130                 1135                 1140             


Pro Glu  Asn Asn Tyr Lys Thr  Thr Pro Pro Val Leu  Asp Ser Asp 
    1145                 1150                 1155             


Gly Ser  Phe Phe Leu Tyr Ser  Lys Leu Thr Val Asp  Lys Ser Arg 
    1160                 1165                 1170             


Trp Gln  Gln Gly Asn Val Phe  Ser Cys Ser Val Met  His Glu Ala 
    1175                 1180                 1185             


Leu His  Asn His Tyr Thr Gln  Lys Ser Leu Ser Leu  Ser Pro Gly 
    1190                 1195                 1200             


Lys 
 

<210>  126
<211>  1223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1_981_V45F_3xGS__IgG1_noCH1_Fc_Fusion

<400>  126

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            980                 985                 990         


Gly Gly Gly Ser Asp Lys Thr His  Thr Cys Pro Pro Cys  Pro Ala Pro 
        995                 1000                 1005             


Glu Leu  Leu Gly Gly Pro Ser  Val Phe Leu Phe Pro  Pro Lys Pro 
    1010                 1015                 1020             


Lys Asp  Thr Leu Met Ile Ser  Arg Thr Pro Glu Val  Thr Cys Val 
    1025                 1030                 1035             


Val Val  Asp Val Ser His Glu  Asp Pro Glu Val Lys  Phe Asn Trp 
    1040                 1045                 1050             


Tyr Val  Asp Gly Val Glu Val  His Asn Ala Lys Thr  Lys Pro Arg 
    1055                 1060                 1065             


Glu Glu  Gln Tyr Asn Ser Thr  Tyr Arg Val Val Ser  Val Leu Thr 
    1070                 1075                 1080             


Val Leu  His Gln Asp Trp Leu  Asn Gly Lys Glu Tyr  Lys Cys Lys 
    1085                 1090                 1095             


Val Ser  Asn Lys Ala Leu Pro  Ala Pro Ile Glu Lys  Thr Ile Ser 
    1100                 1105                 1110             


Lys Ala  Lys Gly Gln Pro Arg  Glu Pro Gln Val Tyr  Thr Leu Pro 
    1115                 1120                 1125             


Pro Ser  Arg Asp Glu Leu Thr  Lys Asn Gln Val Ser  Leu Thr Cys 
    1130                 1135                 1140             


Leu Val  Lys Gly Phe Tyr Pro  Ser Asp Ile Ala Val  Glu Trp Glu 
    1145                 1150                 1155             


Ser Asn  Gly Gln Pro Glu Asn  Asn Tyr Lys Thr Thr  Pro Pro Val 
    1160                 1165                 1170             


Leu Asp  Ser Asp Gly Ser Phe  Phe Leu Tyr Ser Lys  Leu Thr Val 
    1175                 1180                 1185             


Asp Lys  Ser Arg Trp Gln Gln  Gly Asn Val Phe Ser  Cys Ser Val 
    1190                 1195                 1200             


Met His  Glu Ala Leu His Asn  His Tyr Thr Gln Lys  Ser Leu Ser 
    1205                 1210                 1215             


Leu Ser  Pro Gly Lys 
    1220             


<210>  127
<211>  1572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA_Signal_HSA_Seq_GS_ECD_34_981

<400>  127

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    610                 615                 620                 


Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro 
625                 630                 635                 640 


Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe 
                645                 650                 655     


Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln 
            660                 665                 670         


Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro 
        675                 680                 685             


Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala 
    690                 695                 700                 


Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr 
705                 710                 715                 720 


Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr 
                725                 730                 735     


His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser 
            740                 745                 750         


Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu 
        755                 760                 765             


Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His 
    770                 775                 780                 


Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn 
785                 790                 795                 800 


Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg 
                805                 810                 815     


His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr 
            820                 825                 830         


Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile 
        835                 840                 845             


Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu 
    850                 855                 860                 


Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr 
865                 870                 875                 880 


Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro 
                885                 890                 895     


Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp 
            900                 905                 910         


Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr 
        915                 920                 925             


Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr 
    930                 935                 940                 


Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu 
945                 950                 955                 960 


Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys 
                965                 970                 975     


Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile 
            980                 985                 990         


Asp Leu Glu Phe Asn His Pro Gln  Ile Phe Ile Val Glu  Asn Gly Trp 
        995                 1000                 1005             


Phe Val  Ser Gly Thr Thr Lys  Arg Asp Asp Ala Lys  Tyr Met Tyr 
    1010                 1015                 1020             


Tyr Leu  Lys Lys Phe Ile Met  Glu Thr Leu Lys Ala  Ile Lys Leu 
    1025                 1030                 1035             


Asp Gly  Val Asp Val Ile Gly  Tyr Thr Ala Trp Ser  Leu Met Asp 
    1040                 1045                 1050             


Gly Phe  Glu Trp His Arg Gly  Tyr Ser Ile Arg Arg  Gly Leu Phe 
    1055                 1060                 1065             


Tyr Val  Asp Phe Leu Ser Gln  Asp Lys Met Leu Leu  Pro Lys Ser 
    1070                 1075                 1080             


Ser Ala  Leu Phe Tyr Gln Lys  Leu Ile Glu Lys Asn  Gly Phe Pro 
    1085                 1090                 1095             


Pro Leu  Pro Glu Asn Gln Pro  Leu Glu Gly Thr Phe  Pro Cys Asp 
    1100                 1105                 1110             


Phe Ala  Trp Gly Val Val Asp  Asn Tyr Ile Gln Val  Asp Thr Thr 
    1115                 1120                 1125             


Leu Ser  Gln Phe Thr Asp Leu  Asn Val Tyr Leu Trp  Asp Val His 
    1130                 1135                 1140             


His Ser  Lys Arg Leu Ile Lys  Val Asp Gly Val Val  Thr Lys Lys 
    1145                 1150                 1155             


Arg Lys  Ser Tyr Cys Val Asp  Phe Ala Ala Ile Gln  Pro Gln Ile 
    1160                 1165                 1170             


Ala Leu  Leu Gln Glu Met His  Val Thr His Phe Arg  Phe Ser Leu 
    1175                 1180                 1185             


Asp Trp  Ala Leu Ile Leu Pro  Leu Gly Asn Gln Ser  Gln Val Asn 
    1190                 1195                 1200             


His Thr  Ile Leu Gln Tyr Tyr  Arg Cys Met Ala Ser  Glu Leu Val 
    1205                 1210                 1215             


Arg Val  Asn Ile Thr Pro Val  Val Ala Leu Trp Gln  Pro Met Ala 
    1220                 1225                 1230             


Pro Asn  Gln Gly Leu Pro Arg  Leu Leu Ala Arg Gln  Gly Ala Trp 
    1235                 1240                 1245             


Glu Asn  Pro Tyr Thr Ala Leu  Ala Phe Ala Glu Tyr  Ala Arg Leu 
    1250                 1255                 1260             


Cys Phe  Gln Glu Leu Gly His  His Val Lys Leu Trp  Ile Thr Met 
    1265                 1270                 1275             


Asn Glu  Pro Tyr Thr Arg Asn  Met Thr Tyr Ser Ala  Gly His Asn 
    1280                 1285                 1290             


Leu Leu  Lys Ala His Ala Leu  Ala Trp His Val Tyr  Asn Glu Lys 
    1295                 1300                 1305             


Phe Arg  His Ala Gln Asn Gly  Lys Ile Ser Ile Ala  Leu Gln Ala 
    1310                 1315                 1320             


Asp Trp  Ile Glu Pro Ala Cys  Pro Phe Ser Gln Lys  Asp Lys Glu 
    1325                 1330                 1335             


Val Ala  Glu Arg Val Leu Glu  Phe Asp Ile Gly Trp  Leu Ala Glu 
    1340                 1345                 1350             


Pro Ile  Phe Gly Ser Gly Asp  Tyr Pro Trp Val Met  Arg Asp Trp 
    1355                 1360                 1365             


Leu Asn  Gln Arg Asn Asn Phe  Leu Leu Pro Tyr Phe  Thr Glu Asp 
    1370                 1375                 1380             


Glu Lys  Lys Leu Ile Gln Gly  Thr Phe Asp Phe Leu  Ala Leu Ser 
    1385                 1390                 1395             


His Tyr  Thr Thr Ile Leu Val  Asp Ser Glu Lys Glu  Asp Pro Ile 
    1400                 1405                 1410             


Lys Tyr  Asn Asp Tyr Leu Glu  Val Gln Glu Met Thr  Asp Ile Thr 
    1415                 1420                 1425             


Trp Leu  Asn Ser Pro Ser Gln  Val Ala Val Val Pro  Trp Gly Leu 
    1430                 1435                 1440             


Arg Lys  Val Leu Asn Trp Leu  Lys Phe Lys Tyr Gly  Asp Leu Pro 
    1445                 1450                 1455             


Met Tyr  Ile Ile Ser Asn Gly  Ile Asp Asp Gly Leu  His Ala Glu 
    1460                 1465                 1470             


Asp Asp  Gln Leu Arg Val Tyr  Tyr Met Gln Asn Tyr  Ile Asn Glu 
    1475                 1480                 1485             


Ala Leu  Lys Ala His Ile Leu  Asp Gly Ile Asn Leu  Cys Gly Tyr 
    1490                 1495                 1500             


Phe Ala  Tyr Ser Phe Asn Asp  Arg Thr Ala Pro Arg  Phe Gly Leu 
    1505                 1510                 1515             


Tyr Arg  Tyr Ala Ala Asp Gln  Phe Glu Pro Lys Ala  Ser Met Lys 
    1520                 1525                 1530             


His Tyr  Arg Lys Ile Ile Asp  Ser Asn Gly Phe Pro  Gly Pro Glu 
    1535                 1540                 1545             


Thr Leu  Glu Arg Phe Cys Pro  Glu Glu Phe Thr Val  Cys Thr Glu 
    1550                 1555                 1560             


Cys Ser  Phe Phe His Thr Arg  Lys Ser 
    1565                 1570         


<210>  128
<211>  1581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native_1_981_GS_HSA_Seq

<400>  128

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            980                 985                 990         


Gly Gly Gly Ser Asp Ala His Lys  Ser Glu Val Ala His  Arg Phe Lys 
        995                 1000                 1005             


Asp Leu  Gly Glu Glu Asn Phe  Lys Ala Leu Val Leu  Ile Ala Phe 
    1010                 1015                 1020             


Ala Gln  Tyr Leu Gln Gln Cys  Pro Phe Glu Asp His  Val Lys Leu 
    1025                 1030                 1035             


Val Asn  Glu Val Thr Glu Phe  Ala Lys Thr Cys Val  Ala Asp Glu 
    1040                 1045                 1050             


Ser Ala  Glu Asn Cys Asp Lys  Ser Leu His Thr Leu  Phe Gly Asp 
    1055                 1060                 1065             


Lys Leu  Cys Thr Val Ala Thr  Leu Arg Glu Thr Tyr  Gly Glu Met 
    1070                 1075                 1080             


Ala Asp  Cys Cys Ala Lys Gln  Glu Pro Glu Arg Asn  Glu Cys Phe 
    1085                 1090                 1095             


Leu Gln  His Lys Asp Asp Asn  Pro Asn Leu Pro Arg  Leu Val Arg 
    1100                 1105                 1110             


Pro Glu  Val Asp Val Met Cys  Thr Ala Phe His Asp  Asn Glu Glu 
    1115                 1120                 1125             


Thr Phe  Leu Lys Lys Tyr Leu  Tyr Glu Ile Ala Arg  Arg His Pro 
    1130                 1135                 1140             


Tyr Phe  Tyr Ala Pro Glu Leu  Leu Phe Phe Ala Lys  Arg Tyr Lys 
    1145                 1150                 1155             


Ala Ala  Phe Thr Glu Cys Cys  Gln Ala Ala Asp Lys  Ala Ala Cys 
    1160                 1165                 1170             


Leu Leu  Pro Lys Leu Asp Glu  Leu Arg Asp Glu Gly  Lys Ala Ser 
    1175                 1180                 1185             


Ser Ala  Lys Gln Arg Leu Lys  Cys Ala Ser Leu Gln  Lys Phe Gly 
    1190                 1195                 1200             


Glu Arg  Ala Phe Lys Ala Trp  Ala Val Ala Arg Leu  Ser Gln Arg 
    1205                 1210                 1215             


Phe Pro  Lys Ala Glu Phe Ala  Glu Val Ser Lys Leu  Val Thr Asp 
    1220                 1225                 1230             


Leu Thr  Lys Val His Thr Glu  Cys Cys His Gly Asp  Leu Leu Glu 
    1235                 1240                 1245             


Cys Ala  Asp Asp Arg Ala Asp  Leu Ala Lys Tyr Ile  Cys Glu Asn 
    1250                 1255                 1260             


Gln Asp  Ser Ile Ser Ser Lys  Leu Lys Glu Cys Cys  Glu Lys Pro 
    1265                 1270                 1275             


Leu Leu  Glu Lys Ser His Cys  Ile Ala Glu Val Glu  Asn Asp Glu 
    1280                 1285                 1290             


Met Pro  Ala Asp Leu Pro Ser  Leu Ala Ala Asp Phe  Val Glu Ser 
    1295                 1300                 1305             


Lys Asp  Val Cys Lys Asn Tyr  Ala Glu Ala Lys Asp  Val Phe Leu 
    1310                 1315                 1320             


Gly Met  Phe Leu Tyr Glu Tyr  Ala Arg Arg His Pro  Asp Tyr Ser 
    1325                 1330                 1335             


Val Val  Leu Leu Leu Arg Leu  Ala Lys Thr Tyr Glu  Thr Thr Leu 
    1340                 1345                 1350             


Glu Lys  Cys Cys Ala Ala Ala  Asp Pro His Glu Cys  Tyr Ala Lys 
    1355                 1360                 1365             


Val Phe  Asp Glu Phe Lys Pro  Leu Val Glu Glu Pro  Gln Asn Leu 
    1370                 1375                 1380             


Ile Lys  Gln Asn Cys Glu Leu  Phe Glu Gln Leu Gly  Glu Tyr Lys 
    1385                 1390                 1395             


Phe Gln  Asn Ala Leu Leu Val  Arg Tyr Thr Lys Lys  Val Pro Gln 
    1400                 1405                 1410             


Val Ser  Thr Pro Thr Leu Val  Glu Val Ser Arg Asn  Leu Gly Lys 
    1415                 1420                 1425             


Val Gly  Ser Lys Cys Cys Lys  His Pro Glu Ala Lys  Arg Met Pro 
    1430                 1435                 1440             


Cys Ala  Glu Asp Tyr Leu Ser  Val Val Leu Asn Gln  Leu Cys Val 
    1445                 1450                 1455             


Leu His  Glu Lys Thr Pro Val  Ser Asp Arg Val Thr  Lys Cys Cys 
    1460                 1465                 1470             


Thr Glu  Ser Leu Val Asn Arg  Arg Pro Cys Phe Ser  Ala Leu Glu 
    1475                 1480                 1485             


Val Asp  Glu Thr Tyr Val Pro  Lys Glu Phe Asn Ala  Glu Thr Phe 
    1490                 1495                 1500             


Thr Phe  His Ala Asp Ile Cys  Thr Leu Ser Glu Lys  Glu Arg Gln 
    1505                 1510                 1515             


Ile Lys  Lys Gln Thr Ala Leu  Val Glu Leu Val Lys  His Lys Pro 
    1520                 1525                 1530             


Lys Ala  Thr Lys Glu Gln Leu  Lys Ala Val Met Asp  Asp Phe Ala 
    1535                 1540                 1545             


Ala Phe  Val Glu Lys Cys Cys  Lys Ala Asp Asp Lys  Glu Thr Cys 
    1550                 1555                 1560             


Phe Ala  Glu Glu Gly Lys Lys  Leu Val Ala Ala Ser  Gln Ala Ala 
    1565                 1570                 1575             


Leu Gly  Leu 
    1580     


<210>  129
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS_linker_3x

<400>  129

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  130
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA_Signal

<400>  130

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg 
            20                  


<210>  131
<211>  585
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA_Seq

<400>  131

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  132
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HSA_Full_Signal_Seq

<400>  132

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  133
<211>  989
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native_1_981_GG_6xHis

<400>  133

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp 
        435                 440                 445             


Gly Val Asp Val Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe 
    450                 455                 460                 


Glu Trp His Arg Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp 
465                 470                 475                 480 


Phe Leu Ser Gln Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe 
                485                 490                 495     


Tyr Gln Lys Leu Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn 
            500                 505                 510         


Gln Pro Leu Glu Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val 
        515                 520                 525             


Asp Asn Tyr Ile Gln Val Asp Thr Thr Leu Ser Gln Phe Thr Asp Leu 
    530                 535                 540                 


Asn Val Tyr Leu Trp Asp Val His His Ser Lys Arg Leu Ile Lys Val 
545                 550                 555                 560 


Asp Gly Val Val Thr Lys Lys Arg Lys Ser Tyr Cys Val Asp Phe Ala 
                565                 570                 575     


Ala Ile Gln Pro Gln Ile Ala Leu Leu Gln Glu Met His Val Thr His 
            580                 585                 590         


Phe Arg Phe Ser Leu Asp Trp Ala Leu Ile Leu Pro Leu Gly Asn Gln 
        595                 600                 605             


Ser Gln Val Asn His Thr Ile Leu Gln Tyr Tyr Arg Cys Met Ala Ser 
    610                 615                 620                 


Glu Leu Val Arg Val Asn Ile Thr Pro Val Val Ala Leu Trp Gln Pro 
625                 630                 635                 640 


Met Ala Pro Asn Gln Gly Leu Pro Arg Leu Leu Ala Arg Gln Gly Ala 
                645                 650                 655     


Trp Glu Asn Pro Tyr Thr Ala Leu Ala Phe Ala Glu Tyr Ala Arg Leu 
            660                 665                 670         


Cys Phe Gln Glu Leu Gly His His Val Lys Leu Trp Ile Thr Met Asn 
        675                 680                 685             


Glu Pro Tyr Thr Arg Asn Met Thr Tyr Ser Ala Gly His Asn Leu Leu 
    690                 695                 700                 


Lys Ala His Ala Leu Ala Trp His Val Tyr Asn Glu Lys Phe Arg His 
705                 710                 715                 720 


Ala Gln Asn Gly Lys Ile Ser Ile Ala Leu Gln Ala Asp Trp Ile Glu 
                725                 730                 735     


Pro Ala Cys Pro Phe Ser Gln Lys Asp Lys Glu Val Ala Glu Arg Val 
            740                 745                 750         


Leu Glu Phe Asp Ile Gly Trp Leu Ala Glu Pro Ile Phe Gly Ser Gly 
        755                 760                 765             


Asp Tyr Pro Trp Val Met Arg Asp Trp Leu Asn Gln Arg Asn Asn Phe 
    770                 775                 780                 


Leu Leu Pro Tyr Phe Thr Glu Asp Glu Lys Lys Leu Ile Gln Gly Thr 
785                 790                 795                 800 


Phe Asp Phe Leu Ala Leu Ser His Tyr Thr Thr Ile Leu Val Asp Ser 
                805                 810                 815     


Glu Lys Glu Asp Pro Ile Lys Tyr Asn Asp Tyr Leu Glu Val Gln Glu 
            820                 825                 830         


Met Thr Asp Ile Thr Trp Leu Asn Ser Pro Ser Gln Val Ala Val Val 
        835                 840                 845             


Pro Trp Gly Leu Arg Lys Val Leu Asn Trp Leu Lys Phe Lys Tyr Gly 
    850                 855                 860                 


Asp Leu Pro Met Tyr Ile Ile Ser Asn Gly Ile Asp Asp Gly Leu His 
865                 870                 875                 880 


Ala Glu Asp Asp Gln Leu Arg Val Tyr Tyr Met Gln Asn Tyr Ile Asn 
                885                 890                 895     


Glu Ala Leu Lys Ala His Ile Leu Asp Gly Ile Asn Leu Cys Gly Tyr 
            900                 905                 910         


Phe Ala Tyr Ser Phe Asn Asp Arg Thr Ala Pro Arg Phe Gly Leu Tyr 
        915                 920                 925             


Arg Tyr Ala Ala Asp Gln Phe Glu Pro Lys Ala Ser Met Lys His Tyr 
    930                 935                 940                 


Arg Lys Ile Ile Asp Ser Asn Gly Phe Pro Gly Pro Glu Thr Leu Glu 
945                 950                 955                 960 


Arg Phe Cys Pro Glu Glu Phe Thr Val Cys Thr Glu Cys Ser Phe Phe 
                965                 970                 975     


His Thr Arg Lys Ser Gly Gly His His His His His His 
            980                 985                 


<210>  134
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GG_6xHis

<400>  134

Gly Gly His His His His His His 
1               5               


<210>  135
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  6xHis

<400>  135

His His His His His His 
1               5       


<210>  136
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GG_linker

<400>  136

Gly Gly 
1       


<210>  137
<211>  3654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1_981_2xGS_linker_ IgG1-noCH1-Fc

<400>  137
atgcccgcca gcgccccgcc gcgccgcccg cggccgccgc cgccgtcgct gtcgctgctg       60

ctggtgctgc tgggcctggg cggccgccgc ctgcgtgcgg agccgggcga cggcgcgcag      120

acctgggccc gtttctcgcg gcctcctgcc cccgaggccg cgggcctctt ccagggcacc      180

ttccccgacg gcttcctctg ggccgtgggc agcgccgcct accagaccga gggcggctgg      240

cagcagcacg gcaagggtgc gtccatctgg gatacgttca cccaccaccc cctggcaccc      300

ccgggagact cccggaacgc cagtctgccg ttgggcgccc cgtcgccgct gcagcccgcc      360

accggggacg tagccagcga cagctacaac aacgtcttcc gcgacacgga ggcgctgcgc      420

gagctcgggg tcactcacta ccgcttctcc atctcgtggg cgcgagtgct ccccaatggc      480

agcgcgggcg tccccaaccg cgaggggctg cgctactacc ggcgcctgct ggagcggctg      540

cgggagctgg gcgtgcagcc cgtggtcacc ctgtaccact gggacctgcc ccagcgcctg      600

caggacgcct acggcggctg ggccaaccgc gccctggccg accacttcag ggattacgcg      660

gagctctgct tccgccactt cggcggtcag gtcaagtact ggatcaccat cgacaacccc      720

tacgtggtgg cctggcacgg ctacgccacc gggcgcctgg cccccggcat ccggggcagc      780

ccgcggctcg ggtacctggt ggcgcacaac ctcctcctgg ctcatgccaa agtctggcat      840

ctctacaata cttctttccg tcccactcag ggaggtcagg tgtccattgc cctaagctct      900

cactggatca atcctcgaag aatgaccgac cacagcatca aagaatgtca aaaatctctg      960

gactttgtac taggttggtt tgccaaaccc gtatttattg atggtgacta tcccgagagc     1020

atgaagaata acctttcatc tattctgcct gattttactg aatctgagaa aaagttcatc     1080

aaaggaactg ctgacttttt tgctctttgc tttggaccca ccttgagttt tcaacttttg     1140

gaccctcaca tgaagttccg ccaattggaa tctcccaacc tgaggcaact gctttcctgg     1200

attgaccttg aatttaacca tcctcaaata tttattgtgg aaaatggctg gtttgtctca     1260

gggaccacca agagagatga tgccaaatat atgtattacc tcaaaaagtt catcatggaa     1320

accttaaaag ccatcaagct ggatggggtg gatgtcatcg ggtataccgc atggtccctc     1380

atggatggtt tcgagtggca cagaggttac agcatcaggc gtggactctt ctatgttgac     1440

tttctaagcc aggacaagat gttgttgcca aagtcttcag ccttgttcta ccaaaagctg     1500

atagagaaaa atggcttccc tcctttacct gaaaatcagc ccctagaagg gacatttccc     1560

tgtgactttg cttggggagt tgttgacaac tacattcaag tagataccac tctgtctcag     1620

tttaccgacc tgaatgttta cctgtgggat gtccaccaca gtaaaaggct tattaaagtg     1680

gatggggttg tgaccaagaa gaggaaatcc tactgtgttg actttgctgc catccagccc     1740

cagatcgctt tactccagga aatgcacgtt acacattttc gcttctccct ggactgggcc     1800

ctgattctcc ctctgggtaa ccagtcccag gtgaaccaca ccatcctgca gtactatcgc     1860

tgcatggcca gcgagcttgt ccgtgtcaac atcaccccag tggtggccct gtggcagcct     1920

atggccccga accaaggact gccgcgcctc ctggccaggc agggcgcctg ggagaacccc     1980

tacactgccc tggcctttgc agagtatgcc cgactgtgct ttcaagagct cggccatcac     2040

gtcaagcttt ggataacgat gaatgagccg tatacaagga atatgacata cagtgctggc     2100

cacaaccttc tgaaggccca tgccctggct tggcatgtgt acaatgaaaa gtttaggcat     2160

gctcagaatg ggaaaatatc catagccttg caggctgatt ggatagaacc tgcctgccct     2220

ttctcccaaa aggacaaaga ggtggccgag agagttttgg aatttgacat tggctggctg     2280

gctgagccca ttttcggctc tggagattat ccatgggtga tgagggactg gctgaaccaa     2340

agaaacaatt ttcttcttcc ttatttcact gaagatgaaa aaaagctaat ccagggtacc     2400

tttgactttt tggctttaag ccattatacc accatccttg tagactcaga aaaagaagat     2460

ccaataaaat acaatgatta cctagaagtg caagaaatga ccgacatcac gtggctcaac     2520

tcccccagtc aggtggcggt agtgccctgg gggttgcgca aagtgctgaa ctggctgaag     2580

ttcaagtacg gagacctccc catgtacata atatccaacg gaatcgatga cgggctgcat     2640

gctgaggacg accagctgag ggtgtattat atgcagaatt acataaacga agctctcaaa     2700

gcccacatac tggatggtat caatctttgc ggatactttg cttattcgtt taacgaccgc     2760

acagctccga ggtttggcct ctatcgttat gctgcagatc agtttgagcc caaggcatcc     2820

atgaaacatt acaggaaaat tattgacagc aatggtttcc cgggcccaga aactctggaa     2880

agattttgtc cagaagaatt cacagtatgt accgaatgct cattcttcca cactcgcaaa     2940

tctggcggcg gcgggtctgg tggggggggc agtgataaga cccatacgtg tccaccatgt     3000

ccagcgccag aactgttggg aggcccaagt gtcttccttt tcccacctaa gcctaaggac     3060

accttgatga tttcacggac acccgaggtc acgtgtgtgg tggtcgatgt ttcccatgag     3120

gacccagaag ttaaatttaa ttggtatgtg gatggagtcg aggtccacaa cgcgaagact     3180

aagcccagag aggagcagta caatagcacg tatagagtcg tctccgtctt gacggtactt     3240

catcaggatt ggttgaatgg aaaagaatac aaatgtaagg tctcaaataa agcattgcct     3300

gcaccgatcg aaaagacaat cagcaaagcg aagggacagc cccgagaacc acaggtttat     3360

accctgcccc cgtccagaga tgaattgaca aaaaatcagg tctccttgac ctgtctcgtg     3420

aaaggattct atccgagcga tatcgctgta gagtgggaga gcaacggaca acctgaaaac     3480

aattacaaaa caaccccacc cgttcttgac tcagatggtt ccttctttct gtatagcaag     3540

ctcactgttg ataagtcacg atggcagcaa ggtaatgtgt tctcttgctc agttatgcac     3600

gaagcgctgc acaaccacta cactcagaag tccctctccc tcagtcccgg aaaa           3654


<210>  138
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  2xGS_linker

<400>  138
ggcggcggcg ggtctggtgg ggggggcagt                                        30


<210>  139
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1-noCH1-Fc

<400>  139
gataagaccc atacgtgtcc accatgtcca gcgccagaac tgttgggagg cccaagtgtc       60

ttccttttcc cacctaagcc taaggacacc ttgatgattt cacggacacc cgaggtcacg      120

tgtgtggtgg tcgatgtttc ccatgaggac ccagaagtta aatttaattg gtatgtggat      180

ggagtcgagg tccacaacgc gaagactaag cccagagagg agcagtacaa tagcacgtat      240

agagtcgtct ccgtcttgac ggtacttcat caggattggt tgaatggaaa agaatacaaa      300

tgtaaggtct caaataaagc attgcctgca ccgatcgaaa agacaatcag caaagcgaag      360

ggacagcccc gagaaccaca ggtttatacc ctgcccccgt ccagagatga attgacaaaa      420

aatcaggtct ccttgacctg tctcgtgaaa ggattctatc cgagcgatat cgctgtagag      480

tgggagagca acggacaacc tgaaaacaat tacaaaacaa ccccacccgt tcttgactca      540

gatggttcct tctttctgta tagcaagctc actgttgata agtcacgatg gcagcaaggt      600

aatgtgttct cttgctcagt tatgcacgaa gcgctgcaca accactacac tcagaagtcc      660

ctctccctca gtcccggaaa a                                                681


<210>  140
<211>  1676
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wtSP_Seq6_Sc

<400>  140
aagcttaccg ccaccatgcc ggcgtccgcc cccccccgcc gcccgaggcc ccccccgccc       60

tccctgtccc tgctcctcgt cctgctcggc ctggggggcc gccggctgcg cgccgagccg      120

ggcgacgggg cccagacctg ggcccgcttc agcaggcccc cggcccccga ggcggcgggt      180

ctgttccagg ggaccttccc ggacggtttc ctgtgggccg tcggctccgc cgcgtaccag      240

acggagggcg ggtggcaaca acacgggaag ggcgcgtcga tctgggacac tttcacccac      300

caccccctgg cccccccggg ggactcgcgg aacgcgagcc tcccgctggg cgcccccagc      360

cccctccagc cggccaccgg cgacgtggcg agcgacagct acaacaatgt cttcagggac      420

accgaggccc tccgggaact cggcgtcacg cactaccgct tcagcatcag ctgggcgcgg      480

gtcctgccga acggctccgc cggcgtgccg aaccgagagg gcctgaggta ctacaggcgc      540

ctcctggaga ggctccggga gctgggcgta cagcccgtcg tcaccctcta ccactgggac      600

ctcccgcagc gcctgcagga cgcgtacggg gggtgggcca accgcgccct ggccgaccac      660

ttccgggact acgccgagct ctgcttccgc cacttcgggg gccaggtcaa gtactggatc      720

accatcgaca acccctacgt cgtggcctgg cacggctacg ccaccggtcg cctggccccg      780

ggcatccggg gctccccgcg gctgggctac ctcgtcgcgc ataacctgct gctcgcgcac      840

gcgaaggtct ggcacctcta caacaccagc ttccggccga cccagggcgg ccaggtgagc      900

atcgcgctgt cgagccactg gatcaacccc cgccgtatga ctgaccactc gatcaaggaa      960

tgccagaaga gcctggactt cgtcctgggg tggttcgcca agccggtgtt catcgacggt     1020

gactacccgg aatcgatgaa gaacaacctg tcctcgatcc tgcccgactt caccgagtcc     1080

gagaagaagt tcattaaggg caccgccgac ttcttcgcgc tgtgcttcgg gcccaccctg     1140

tccttccagc tgctggaccc ccacatgaag ttccgccagc tagagtctcc gaacctgcgc     1200

cagctcctgt cgtggatcga cctggagttc aaccacccgc agatcttcat cgtcgagaac     1260

ggctggttcg tctcggggac caccaaacgg gacgacgcca agtatatgta ctacctcaag     1320

aagttcatca tggagaccct gaaggcgatc aagctggacg gggtcgacgt catcgggtac     1380

accgcctggt ccctgatgga cggcttcgag tggcaccgcg gctactcgat cagacgcggc     1440

ctgttctacg tcgacttcct gtcgcaggac aagatgctcc tgccgaagtc cagcgcgctc     1500

ttctaccaga agctgatcga gaagaacggc ttcccaccgc tgcccgagaa ccagccactc     1560

gaaggcacct tcccgtgcga cttcgcctgg ggcgtcgtgg acaactacat ccaggtgtcg     1620

cagctcacga agccgatctc ctcgctcacc aagccgtacc actgataatc tagagt         1676


<210>  141
<211>  3641
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LubSP_Seq3_Sc

<400>  141
aagcttaccg ccaccatggc ctggaagact ctccccatct acctcctgct gctcctgtcg       60

gtcttcgtca tccagcaggt gtcctccgag ccgggcgacg gcgcgcagac ctgggcgcgc      120

ttcagccggc cgccggcccc ggaggcagcc ggcctgttcc aggggacctt cccggacggc      180

ttcctctggg ccgtcggctc ggccgcctac cagaccgagg gtggctggca gcagcacggc      240

aagggcgcct ccatctggga caccttcacc caccacccgc tggccccgcc gggcgactcc      300

cgcaacgcct ccctgccgct gggcgccccc tcgcccctgc agccggccac cggcgacgtg      360

gcgtcggaca gctacaacaa cgtgttccgc gacaccgaag ccctgcggga gctgggcgtc      420

acccactacc gcttctccat cagctgggct agggtcctgc ccaacggcag cgcgggcgtg      480

cccaaccgcg agggcctgcg ttactaccgg cgcctgctgg agcgcctgcg cgaactcggg      540

gtccagccgg tcgtcaccct ctaccactgg gatctgcccc agcgccttca ggacgcctac      600

ggcggctggg ccaaccgggc cctggccgac cacttccgcg actacgccga gctctgcttc      660

cgccactttg gcggccaggt caagtactgg atcaccatcg acaacccgta cgtcgtcgcc      720

tggcacggct acgcaaccgg ccggctggcc ccgggcatcc gcggctcccc ccgcctgggc      780

tacctcgtgg cgcacaacct cctgctggcc cacgccaagg tgtggcacct gtacaacacc      840

tccttccgcc cgacccaagg cggccaggtg tccatcgccc tgtccagcca ctggatcaac      900

ccccggcgca tgacggacca ctcgatcaag gagtgccaga agagcctcga cttcgtgctg      960

ggctggttcg cgaagccggt gttcatcgac ggtgactacc cggagtccat gaagaacaac     1020

ctgtcctcga tcctgcccga cttcaccgag agtgagaaga agttcatcaa gggcaccgcc     1080

gacttcttcg cgctctgctt cggccccacc ctctcgttcc agctgctgga cccccacatg     1140

aagttccggc agctggagag cccgaacctg cgccagctcc tgagctggat cgacctcgag     1200

ttcaatcacc cccagatctt catcgtggag aacggttggt tcgtgagcgg caccaccaag     1260

cgcgacgacg ccaaatacat gtactacctg aagaagttta tcatggagac cctgaaggcg     1320

atcaagctgg acggcgtcga cgtgatcggc tacaccgcct ggtccctgat ggacggcttc     1380

gagtggcacc gggggtacag catccggcgg ggcctgttct acgtggactt cctgtcgcag     1440

gacaagatgt tgctgcccaa gtcgtcggcc ctcttctacc agaagctgat cgagaagaac     1500

ggcttcccgc cgctgcccga gaaccagccc ctggagggca ccttcccgtg cgacttcgcc     1560

tggggcgtcg tggacaacta catccaggtc gacaccaccc tgagccagtt cacagacctc     1620

aacgtgtacc tctgggacgt gcaccacagc aaacgcctca tcaaggtcga cggcgtagtc     1680

accaagaagc ggaagagcta ttgcgtggac ttcgccgcga ttcaacccca aatcgcgctc     1740

ctccaggaga tgcacgtcac ccacttcagg ttcagcctcg actgggcgct gatcctgccg     1800

ctcgggaacc agtcgcaggt gaaccacacg atcctgcaat actacaggtg catggcgtcg     1860

gagctcgtcc gggtcaacat cacccccgtg gtcgccctct ggcagcccat ggcgcccaac     1920

cagggcctgc cccgcctcct ggcccgccag ggcgcctggg agaacccgta caccgcgctg     1980

gccttcgcgg agtacgcgcg cctctgcttc caggagctgg ggcaccacgt gaagctgtgg     2040

atcaccatga acgaacccta cacgcgcaac atgacataca gcgcggggca caacctgctg     2100

aaggcacacg ccctcgcgtg gcacgtctac aacgaaaagt tccggcacgc ccagaacggc     2160

aagatctcca tcgccctcca ggccgactgg atcgagcctg cctgcccgtt ctcgcagaag     2220

gacaaagagg tggccgagcg ggtgctggag ttcgacatcg gttggctggc ggagccgatc     2280

ttcggctccg gcgactaccc ctgggtcatg cgggactggc tgaaccagcg caacaacttc     2340

ttgcttccct acttcaccga agacgaaaag aagctgatcc agggaacctt cgacttcctc     2400

gccctcagcc actacaccac catcttggtc gactcggaga aggaggaccc catcaagtac     2460

aacgattacc tcgaggtcca ggagatgacg gacatcacgt ggctcaactc gccgtcccag     2520

gtcgcggtgg tcccctgggg cctgcggaag gtgctcaact ggctgaagtt caagtacggc     2580

gacctcccca tgtacatcat cagcaacgga atcgacgacg gcctgcacgc cgaggacgac     2640

cagctccgtg tctactacat gcagaactac atcaacgagg ccctgaaggc ccacatcctg     2700

gacggcatca acctgtgtgg ttacttcgcc tactcattca acgaccgcac cgccccccgg     2760

ttcggcctct acaggtacgc ggcggaccag ttcgagccca aggcgtcgat gaagcactac     2820

cgcaagatca tcgacagcaa cggcttcccc ggcccggaga ccctcgaacg cttctgcccc     2880

gaggagttca cggtgtgcac cgagtgcagc ttcttccaca cccgcaagtc gggcgggggc     2940

ggcagcggcg gcggcggctc ggacaagacc cacacctgtc ccccctgccc cgcccccgag     3000

ctgctgggtg gcccgtccgt cttcctgttc cccccgaagc cgaaggacac tctcatgatc     3060

tcccggaccc ccgaggtcac ctgcgtggtc gtagacgtgt cccacgagga cccggaggtg     3120

aagttcaact ggtacgtgga cggcgtggaa gtccacaacg ccaagaccaa gccgcgcgaa     3180

gagcagtaca actcgaccta ccgggtcgtc agcgtcctca cggtcctgca ccaggactgg     3240

ctcaatggga aggaatacaa gtgcaaggtg tccaacaagg cgctgcccgc ccccatcgag     3300

aagaccatca gcaaggccaa ggggcagccg cgggaaccgc aggtctacac gctcccgccc     3360

agccgggacg agctcaccaa gaatcaggtc agtctgacct gcctggtgaa gggcttctac     3420

ccgagtgaca tcgccgtgga gtgggagtcg aatggccagc ccgagaacaa ctacaagaca     3480

acgccccccg tcctggactc cgacggctcc ttcttcctgt actcgaagct cacggtcgac     3540

aagagccggt ggcagcaggg caacgtgttc agctgcagcg tcatgcacga ggccctgcac     3600

aaccactaca cgcagaagag cctgtcgctg tccccgggaa a                         3641


<210>  142
<211>  2972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wtSP_Seq2_Sc

<400>  142
aagcttaccg ccaccatgcc cgcctccgcg cccccccgcc gcccgcgtcc tcccccgccg       60

agcctctccc tgctgctggt gctcctgggc ctgggcggac gccggctccg cgccgagccg      120

ggcgacggcg cgcagacctg ggcgcgcgtg agccggccgc cggccccgga ggcagccggc      180

ctgttccagg ggaccttccc ggacggcttc ctctgggccg tcggctcggc cgcctaccag      240

accgagggtg gctggcagca gcacggcaag ggcgcctcca tctgggacac cttcacccac      300

cacccgctgg ccccgccggg cgactcccgc aacgcctccc tgccgctggg cgccccctcg      360

cccctgcagc cggccaccgg cgacgtggcg tcggacagct acaacaacgt gttccgcgac      420

accgaagccc tgcgggagct gggcgtcacc cactaccgct tctccatcag ctgggctagg      480

gtcctgccca acggcagcgc gggcgtgccc aaccgcgagg gcctgcgtta ctaccggcgc      540

ctgctggagc gcctgcgcga actcggggtc cagccggtcg tcaccctcta ccactgggat      600

ctgccccagc gccttcagga cgcctacggc ggctgggcca accgggccct ggccgaccac      660

ttccgcgact acgccgagct ctgcttccgc cactttggcg gccaggtcaa gtactggatc      720

accatcgaca acccgtacgt cgtcgcctgg cacggctacg caaccggccg gctggccccg      780

ggcatccgcg gctccccccg cctgggctac ctcgtggcgc acaacctcct gctggcccac      840

gccaaggtgt ggcacctgta caacacctcc ttccgcccga cccaaggcgg ccaggtgtcc      900

atcgccctgt ccagccactg gatcaacccc cggcgcatga cggaccactc gatcaaggag      960

tgccagaaga gcctcgactt cgtgctgggc tggttcgcga agccggtgtt catcgacggt     1020

gactacccgg agtccatgaa gaacaacctg tcctcgatcc tgcccgactt caccgagagt     1080

gagaagaagt tcatcaaggg caccgccgac ttcttcgcgc tctgcttcgg ccccaccctc     1140

tcgttccagc tgctggaccc ccacatgaag ttccggcagc tggagagccc gaacctgcgc     1200

cagctcctga gctggatcga cctcgagttc aatcaccccc agatcttcat cgtggagaac     1260

ggttggttcg tgagcggcac caccaagcgc gacgacgcca aatacatgta ctacctgaag     1320

aagtttatca tggagaccct gaaggcgatc aagctggacg gcgtcgacgt gatcggctac     1380

accgcctggt ccctgatgga cggcttcgag tggcaccggg ggtacagcat ccggcggggc     1440

ctgttctacg tggacttcct gtcgcaggac aagatgttgc tgcccaagtc gtcggccctc     1500

ttctaccaga agctgatcga gaagaacggc ttcccgccgc tgcccgagaa ccagcccctg     1560

gagggcacct tcccgtgcga cttcgcctgg ggcgtcgtgg acaactacat ccaggtcgac     1620

accaccctga gccagttcac agacctcaac gtgtacctct gggacgtgca ccacagcaaa     1680

cgcctcatca aggtcgacgg cgtagtcacc aagaagcgga agagctattg cgtggacttc     1740

gccgcgattc aaccccaaat cgcgctcctc caggagatgc acgtcaccca cttcaggttc     1800

agcctcgact gggcgctgat cctgccgctc gggaaccagt cgcaggtgaa ccacacgatc     1860

ctgcaatact acaggtgcat ggcgtcggag ctcgtccggg tcaacatcac ccccgtggtc     1920

gccctctggc agcccatggc gcccaaccag ggcctgcccc gcctcctggc ccgccagggc     1980

gcctgggaga acccgtacac cgcgctggcc ttcgcggagt acgcgcgcct ctgcttccag     2040

gagctggggc accacgtgaa gctgtggatc accatgaacg aaccctacac gcgcaacatg     2100

acatacagcg cggggcacaa cctgctgaag gcacacgccc tcgcgtggca cgtctacaac     2160

gaaaagttcc ggcacgccca gaacggcaag atctccatcg ccctccaggc cgactggatc     2220

gagcctgcct gcccgttctc gcagaaggac aaagaggtgg ccgagcgggt gctggagttc     2280

gacatcggtt ggctggcgga gccgatcttc ggctccggcg actacccctg ggtcatgcgg     2340

gactggctga accagcgcaa caacttcttg cttccctact tcaccgaaga cgaaaagaag     2400

ctgatccagg gaaccttcga cttcctcgcc ctcagccact acaccaccat cttggtcgac     2460

tcggagaagg aggaccccat caagtacaac gattacctcg aggtccagga gatgacggac     2520

atcacgtggc tcaactcgcc gtcccaggtc gcggtggtcc cctggggcct gcggaaggtg     2580

ctcaactggc tgaagttcaa gtacggcgac ctccccatgt acatcatcag caacggaatc     2640

gacgacggcc tgcacgccga ggacgaccag ctccgtgtct actacatgca gaactacatc     2700

aacgaggccc tgaaggccca catcctggac ggcatcaacc tgtgtggtta cttcgcctac     2760

tcattcaacg accgcaccgc cccccggttc ggcctctaca ggtacgcggc ggaccagttc     2820

gagcccaagg cgtcgatgaa gcactaccgc aagatcatcg acagcaacgg cttccccggc     2880

ccggagaccc tcgaacgctt ctgccccgag gagttcacgg tgtgcaccga gtgcagcttc     2940

ttccacaccc gcaagtcgtg ataatctaga gt                                   2972


<210>  143
<211>  2945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LubSP_Seq2_Sc

<400>  143
aagcttaccg ccaccatggc ctggaagact ctccccatct acctcctgct gctcctgtcg       60

gtcttcgtca tccagcaggt gtcctccgag ccgggcgacg gcgcgcagac ctgggcgcgc      120

gtgagccggc cgccggcccc ggaggcagcc ggcctgttcc aggggacctt cccggacggc      180

ttcctctggg ccgtcggctc ggccgcctac cagaccgagg gtggctggca gcagcacggc      240

aagggcgcct ccatctggga caccttcacc caccacccgc tggccccgcc gggcgactcc      300

cgcaacgcct ccctgccgct gggcgccccc tcgcccctgc agccggccac cggcgacgtg      360

gcgtcggaca gctacaacaa cgtgttccgc gacaccgaag ccctgcggga gctgggcgtc      420

acccactacc gcttctccat cagctgggct agggtcctgc ccaacggcag cgcgggcgtg      480

cccaaccgcg agggcctgcg ttactaccgg cgcctgctgg agcgcctgcg cgaactcggg      540

gtccagccgg tcgtcaccct ctaccactgg gatctgcccc agcgccttca ggacgcctac      600

ggcggctggg ccaaccgggc cctggccgac cacttccgcg actacgccga gctctgcttc      660

cgccactttg gcggccaggt caagtactgg atcaccatcg acaacccgta cgtcgtcgcc      720

tggcacggct acgcaaccgg ccggctggcc ccgggcatcc gcggctcccc ccgcctgggc      780

tacctcgtgg cgcacaacct cctgctggcc cacgccaagg tgtggcacct gtacaacacc      840

tccttccgcc cgacccaagg cggccaggtg tccatcgccc tgtccagcca ctggatcaac      900

ccccggcgca tgacggacca ctcgatcaag gagtgccaga agagcctcga cttcgtgctg      960

ggctggttcg cgaagccggt gttcatcgac ggtgactacc cggagtccat gaagaacaac     1020

ctgtcctcga tcctgcccga cttcaccgag agtgagaaga agttcatcaa gggcaccgcc     1080

gacttcttcg cgctctgctt cggccccacc ctctcgttcc agctgctgga cccccacatg     1140

aagttccggc agctggagag cccgaacctg cgccagctcc tgagctggat cgacctcgag     1200

ttcaatcacc cccagatctt catcgtggag aacggttggt tcgtgagcgg caccaccaag     1260

cgcgacgacg ccaaatacat gtactacctg aagaagttta tcatggagac cctgaaggcg     1320

atcaagctgg acggcgtcga cgtgatcggc tacaccgcct ggtccctgat ggacggcttc     1380

gagtggcacc gggggtacag catccggcgg ggcctgttct acgtggactt cctgtcgcag     1440

gacaagatgt tgctgcccaa gtcgtcggcc ctcttctacc agaagctgat cgagaagaac     1500

ggcttcccgc cgctgcccga gaaccagccc ctggagggca ccttcccgtg cgacttcgcc     1560

tggggcgtcg tggacaacta catccaggtc gacaccaccc tgagccagtt cacagacctc     1620

aacgtgtacc tctgggacgt gcaccacagc aaacgcctca tcaaggtcga cggcgtagtc     1680

accaagaagc ggaagagcta ttgcgtggac ttcgccgcga ttcaacccca aatcgcgctc     1740

ctccaggaga tgcacgtcac ccacttcagg ttcagcctcg actgggcgct gatcctgccg     1800

ctcgggaacc agtcgcaggt gaaccacacg atcctgcaat actacaggtg catggcgtcg     1860

gagctcgtcc gggtcaacat cacccccgtg gtcgccctct ggcagcccat ggcgcccaac     1920

cagggcctgc cccgcctcct ggcccgccag ggcgcctggg agaacccgta caccgcgctg     1980

gccttcgcgg agtacgcgcg cctctgcttc caggagctgg ggcaccacgt gaagctgtgg     2040

atcaccatga acgaacccta cacgcgcaac atgacataca gcgcggggca caacctgctg     2100

aaggcacacg ccctcgcgtg gcacgtctac aacgaaaagt tccggcacgc ccagaacggc     2160

aagatctcca tcgccctcca ggccgactgg atcgagcctg cctgcccgtt ctcgcagaag     2220

gacaaagagg tggccgagcg ggtgctggag ttcgacatcg gttggctggc ggagccgatc     2280

ttcggctccg gcgactaccc ctgggtcatg cgggactggc tgaaccagcg caacaacttc     2340

ttgcttccct acttcaccga agacgaaaag aagctgatcc agggaacctt cgacttcctc     2400

gccctcagcc actacaccac catcttggtc gactcggaga aggaggaccc catcaagtac     2460

aacgattacc tcgaggtcca ggagatgacg gacatcacgt ggctcaactc gccgtcccag     2520

gtcgcggtgg tcccctgggg cctgcggaag gtgctcaact ggctgaagtt caagtacggc     2580

gacctcccca tgtacatcat cagcaacgga atcgacgacg gcctgcacgc cgaggacgac     2640

cagctccgtg tctactacat gcagaactac atcaacgagg ccctgaaggc ccacatcctg     2700

gacggcatca acctgtgtgg ttacttcgcc tactcattca acgaccgcac cgccccccgg     2760

ttcggcctct acaggtacgc ggcggaccag ttcgagccca aggcgtcgat gaagcactac     2820

cgcaagatca tcgacagcaa cggcttcccc ggcccggaga ccctcgaacg cttctgcccc     2880

gaggagttca cggtgtgcac cgagtgcagc ttcttccaca cccgcaagtc gtgataatct     2940

agagt                                                                 2945


<210>  144
<211>  3656
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LubSP_Seq1_Sc

<400>  144
aagcttaccg ccaccatggc ctggaagact ctccccatct acctcctgct gctcctgtcg       60

gtcttcgtca tccagcaggt gtcctccgag ccgggcgacg gcgcgcagac ctgggcgcgc      120

gtgagccggc cgccggcccc ggaggcagcc ggcctgttcc aggggacctt cccggacggc      180

ttcctctggg ccgtcggctc ggccgcctac cagaccgagg gtggctggca gcagcacggc      240

aagggcgcct ccatctggga caccttcacc caccacccgc tggccccgcc gggcgactcc      300

cgcaacgcct ccctgccgct gggcgccccc tcgcccctgc agccggccac cggcgacgtg      360

gcgtcggaca gctacaacaa cgtgttccgc gacaccgaag ccctgcggga gctgggcgtc      420

acccactacc gcttctccat cagctgggct agggtcctgc ccaacggcag cgcgggcgtg      480

cccaaccgcg agggcctgcg ttactaccgg cgcctgctgg agcgcctgcg cgaactcggg      540

gtccagccgg tcgtcaccct ctaccactgg gatctgcccc agcgccttca ggacgcctac      600

ggcggctggg ccaaccgggc cctggccgac cacttccgcg actacgccga gctctgcttc      660

cgccactttg gcggccaggt caagtactgg atcaccatcg acaacccgta cgtcgtcgcc      720

tggcacggct acgcaaccgg ccggctggcc ccgggcatcc gcggctcccc ccgcctgggc      780

tacctcgtgg cgcacaacct cctgctggcc cacgccaagg tgtggcacct gtacaacacc      840

tccttccgcc cgacccaagg cggccaggtg tccatcgccc tgtccagcca ctggatcaac      900

ccccggcgca tgacggacca ctcgatcaag gagtgccaga agagcctcga cttcgtgctg      960

ggctggttcg cgaagccggt gttcatcgac ggtgactacc cggagtccat gaagaacaac     1020

ctgtcctcga tcctgcccga cttcaccgag agtgagaaga agttcatcaa gggcaccgcc     1080

gacttcttcg cgctctgctt cggccccacc ctctcgttcc agctgctgga cccccacatg     1140

aagttccggc agctggagag cccgaacctg cgccagctcc tgagctggat cgacctcgag     1200

ttcaatcacc cccagatctt catcgtggag aacggttggt tcgtgagcgg caccaccaag     1260

cgcgacgacg ccaaatacat gtactacctg aagaagttta tcatggagac cctgaaggcg     1320

atcaagctgg acggcgtcga cgtgatcggc tacaccgcct ggtccctgat ggacggcttc     1380

gagtggcacc gggggtacag catccggcgg ggcctgttct acgtggactt cctgtcgcag     1440

gacaagatgt tgctgcccaa gtcgtcggcc ctcttctacc agaagctgat cgagaagaac     1500

ggcttcccgc cgctgcccga gaaccagccc ctggagggca ccttcccgtg cgacttcgcc     1560

tggggcgtcg tggacaacta catccaggtc gacaccaccc tgagccagtt cacagacctc     1620

aacgtgtacc tctgggacgt gcaccacagc aaacgcctca tcaaggtcga cggcgtagtc     1680

accaagaagc ggaagagcta ttgcgtggac ttcgccgcga ttcaacccca aatcgcgctc     1740

ctccaggaga tgcacgtcac ccacttcagg ttcagcctcg actgggcgct gatcctgccg     1800

ctcgggaacc agtcgcaggt gaaccacacg atcctgcaat actacaggtg catggcgtcg     1860

gagctcgtcc gggtcaacat cacccccgtg gtcgccctct ggcagcccat ggcgcccaac     1920

cagggcctgc cccgcctcct ggcccgccag ggcgcctggg agaacccgta caccgcgctg     1980

gccttcgcgg agtacgcgcg cctctgcttc caggagctgg ggcaccacgt gaagctgtgg     2040

atcaccatga acgaacccta cacgcgcaac atgacataca gcgcggggca caacctgctg     2100

aaggcacacg ccctcgcgtg gcacgtctac aacgaaaagt tccggcacgc ccagaacggc     2160

aagatctcca tcgccctcca ggccgactgg atcgagcctg cctgcccgtt ctcgcagaag     2220

gacaaagagg tggccgagcg ggtgctggag ttcgacatcg gttggctggc ggagccgatc     2280

ttcggctccg gcgactaccc ctgggtcatg cgggactggc tgaaccagcg caacaacttc     2340

ttgcttccct acttcaccga agacgaaaag aagctgatcc agggaacctt cgacttcctc     2400

gccctcagcc actacaccac catcttggtc gactcggaga aggaggaccc catcaagtac     2460

aacgattacc tcgaggtcca ggagatgacg gacatcacgt ggctcaactc gccgtcccag     2520

gtcgcggtgg tcccctgggg cctgcggaag gtgctcaact ggctgaagtt caagtacggc     2580

gacctcccca tgtacatcat cagcaacgga atcgacgacg gcctgcacgc cgaggacgac     2640

cagctccgtg tctactacat gcagaactac atcaacgagg ccctgaaggc ccacatcctg     2700

gacggcatca acctgtgtgg ttacttcgcc tactcattca acgaccgcac cgccccccgg     2760

ttcggcctct acaggtacgc ggcggaccag ttcgagccca aggcgtcgat gaagcactac     2820

cgcaagatca tcgacagcaa cggcttcccc ggcccggaga ccctcgaacg cttctgcccc     2880

gaggagttca cggtgtgcac cgagtgcagc ttcttccaca cccgcaagtc gggcgggggc     2940

ggcagcggcg gcggcggctc ggacaagacc cacacctgtc ccccctgccc cgcccccgag     3000

ctgctgggtg gcccgtccgt cttcctgttc cccccgaagc cgaaggacac tctcatgatc     3060

tcccggaccc ccgaggtcac ctgcgtggtc gtagacgtgt cccacgagga cccggaggtg     3120

aagttcaact ggtacgtgga cggcgtggaa gtccacaacg ccaagaccaa gccgcgcgaa     3180

gagcagtaca actcgaccta ccgggtcgtc agcgtcctca cggtcctgca ccaggactgg     3240

ctcaatggga aggaatacaa gtgcaaggtg tccaacaagg cgctgcccgc ccccatcgag     3300

aagaccatca gcaaggccaa ggggcagccg cgggaaccgc aggtctacac gctcccgccc     3360

agccgggacg agctcaccaa gaatcaggtc agtctgacct gcctggtgaa gggcttctac     3420

ccgagtgaca tcgccgtgga gtgggagtcg aatggccagc ccgagaacaa ctacaagaca     3480

acgccccccg tcctggactc cgacggctcc ttcttcctgt actcgaagct cacggtcgac     3540

aagagccggt ggcagcaggg caacgtgttc agctgcagcg tcatgcacga ggccctgcac     3600

aaccactaca cgcagaagag cctgtcgctg tccccgggaa agtgataatc tagagt         3656


<210>  145
<211>  2387
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wtSP_Seq5_Sc

<400>  145
aagcttaccg ccaccatgcc ggcgtccgcc cccccccgcc gcccgaggcc ccccccgccc       60

tccctgtccc tgctcctcgt cctgctcggc ctggggggcc gccggctgcg cgccgagccg      120

ggcgacgggg cccagacctg ggcccgcttc agcaggcccc cggcccccga ggcggcgggt      180

ctgttccagg ggaccttccc ggacggtttc ctgtgggccg tcggctccgc cgcgtaccag      240

acggagggcg ggtggcaaca acacgggaag ggcgcgtcga tctgggacac tttcacccac      300

caccccctgg cccccccggg ggactcgcgg aacgcgagcc tcccgctggg cgcccccagc      360

cccctccagc cggccaccgg cgacgtggcg agcgacagct acaacaatgt cttcagggac      420

accgaggccc tccgggaact cggcgtcacg cactaccgct tcagcatcag ctgggcgcgg      480

gtcctgccga acggctccgc cggcgtgccg aaccgagagg gcctgaggta ctacaggcgc      540

ctcctggaga ggctccggga gctgggcgta cagcccgtcg tcaccctcta ccactgggac      600

ctcccgcagc gcctgcagga cgcgtacggg gggtgggcca accgcgccct ggccgaccac      660

ttccgggact acgccgagct ctgcttccgc cacttcgggg gccaggtcaa gtactggatc      720

accatcgaca acccctacgt cgtggcctgg cacggctacg ccaccggtcg cctggccccg      780

ggcatccggg gctccccgcg gctgggctac ctcgtcgcgc ataacctgct gctcgcgcac      840

gcgaaggtct ggcacctcta caacaccagc ttccggccga cccagggcgg ccaggtgagc      900

atcgcgctgt cgagccactg gatcaacccc cgccgtatga ctgaccactc gatcaaggaa      960

tgccagaaga gcctggactt cgtcctgggg tggttcgcca agccggtgtt catcgacggt     1020

gactacccgg aatcgatgaa gaacaacctg tcctcgatcc tgcccgactt caccgagtcc     1080

gagaagaagt tcattaaggg caccgccgac ttcttcgcgc tgtgcttcgg gcccaccctg     1140

tccttccagc tgctggaccc ccacatgaag ttccgccagc tagagtctcc gaacctgcgc     1200

cagctcctgt cgtggatcga cctggagttc aaccacccgc agatcttcat cgtcgagaac     1260

ggctggttcg tctcggggac caccaaacgg gacgacgcca agtatatgta ctacctcaag     1320

aagttcatca tggagaccct gaaggcgatc aagctggacg gggtcgacgt catcgggtac     1380

accgcctggt ccctgatgga cggcttcgag tggcaccgcg gctactcgat cagacgcggc     1440

ctgttctacg tcgacttcct gtcgcaggac aagatgctcc tgccgaagtc cagcgcgctc     1500

ttctaccaga agctgatcga gaagaacggc ttcccaccgc tgcccgagaa ccagccactc     1560

gaaggcacct tcccgtgcga cttcgcctgg ggcgtcgtgg acaactacat ccaggtgtcg     1620

cagctcacga agccgatctc ctcgctcacc aagccgtacc acgggggcgg cggtagcggc     1680

ggcggcggct ccgacaagac ccacacctgc ccgccgtgcc ccgcgcccga gctgctcggc     1740

ggcccctccg tcttcctgtt ccctcccaag cccaaggaca cgctgatgat ctcccggacc     1800

cccgaggtca cctgcgtcgt ggtcgacgtg tcgcacgagg acccggaggt gaagttcaac     1860

tggtacgtgg acggtgtgga ggtgcataac gccaagacca agccgcggga agagcagtac     1920

aactccacgt acagggtcgt ctcggtgctg acggtcctgc accaagactg gctgaacggc     1980

aaggagtaca agtgcaaggt gagcaacaag gccctcccgg cgcccatcga gaagaccatc     2040

agcaaggcga agggccagcc gcgggagccg caggtctaca ccctcccgcc gagccgtgac     2100

gaactgacca agaaccaggt ctcgctcacg tgcctggtca aggggttcta cccgagcgac     2160

atcgccgtgg agtgggaatc gaacggccag ccggagaaca actacaagac caccccgccc     2220

gtgctggaca gcgacggctc cttcttcctc tactccaagc tgaccgtcga caagtcgcgc     2280

tggcagcaag ggaacgtgtt ctcctgctcg gtcatgcacg aggccctgca caaccactat     2340

acccaaaaga gtctgtcgct gtccccgggg aagtgataat ctagagt                   2387


<210>  146
<211>  3683
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wtSP_Seq3_Sc

<400>  146
aagcttaccg ccaccatgcc cgcctccgcg cccccccgcc gcccgcgtcc tcccccgccg       60

agcctctccc tgctgctggt gctcctgggc ctgggcggac gccggctccg cgccgagccg      120

ggcgacggcg cgcagacctg ggcgcgcttc agccggccgc cggccccgga ggcagccggc      180

ctgttccagg ggaccttccc ggacggcttc ctctgggccg tcggctcggc cgcctaccag      240

accgagggtg gctggcagca gcacggcaag ggcgcctcca tctgggacac cttcacccac      300

cacccgctgg ccccgccggg cgactcccgc aacgcctccc tgccgctggg cgccccctcg      360

cccctgcagc cggccaccgg cgacgtggcg tcggacagct acaacaacgt gttccgcgac      420

accgaagccc tgcgggagct gggcgtcacc cactaccgct tctccatcag ctgggctagg      480

gtcctgccca acggcagcgc gggcgtgccc aaccgcgagg gcctgcgtta ctaccggcgc      540

ctgctggagc gcctgcgcga actcggggtc cagccggtcg tcaccctcta ccactgggat      600

ctgccccagc gccttcagga cgcctacggc ggctgggcca accgggccct ggccgaccac      660

ttccgcgact acgccgagct ctgcttccgc cactttggcg gccaggtcaa gtactggatc      720

accatcgaca acccgtacgt cgtcgcctgg cacggctacg caaccggccg gctggccccg      780

ggcatccgcg gctccccccg cctgggctac ctcgtggcgc acaacctcct gctggcccac      840

gccaaggtgt ggcacctgta caacacctcc ttccgcccga cccaaggcgg ccaggtgtcc      900

atcgccctgt ccagccactg gatcaacccc cggcgcatga cggaccactc gatcaaggag      960

tgccagaaga gcctcgactt cgtgctgggc tggttcgcga agccggtgtt catcgacggt     1020

gactacccgg agtccatgaa gaacaacctg tcctcgatcc tgcccgactt caccgagagt     1080

gagaagaagt tcatcaaggg caccgccgac ttcttcgcgc tctgcttcgg ccccaccctc     1140

tcgttccagc tgctggaccc ccacatgaag ttccggcagc tggagagccc gaacctgcgc     1200

cagctcctga gctggatcga cctcgagttc aatcaccccc agatcttcat cgtggagaac     1260

ggttggttcg tgagcggcac caccaagcgc gacgacgcca aatacatgta ctacctgaag     1320

aagtttatca tggagaccct gaaggcgatc aagctggacg gcgtcgacgt gatcggctac     1380

accgcctggt ccctgatgga cggcttcgag tggcaccggg ggtacagcat ccggcggggc     1440

ctgttctacg tggacttcct gtcgcaggac aagatgttgc tgcccaagtc gtcggccctc     1500

ttctaccaga agctgatcga gaagaacggc ttcccgccgc tgcccgagaa ccagcccctg     1560

gagggcacct tcccgtgcga cttcgcctgg ggcgtcgtgg acaactacat ccaggtcgac     1620

accaccctga gccagttcac agacctcaac gtgtacctct gggacgtgca ccacagcaaa     1680

cgcctcatca aggtcgacgg cgtagtcacc aagaagcgga agagctattg cgtggacttc     1740

gccgcgattc aaccccaaat cgcgctcctc caggagatgc acgtcaccca cttcaggttc     1800

agcctcgact gggcgctgat cctgccgctc gggaaccagt cgcaggtgaa ccacacgatc     1860

ctgcaatact acaggtgcat ggcgtcggag ctcgtccggg tcaacatcac ccccgtggtc     1920

gccctctggc agcccatggc gcccaaccag ggcctgcccc gcctcctggc ccgccagggc     1980

gcctgggaga acccgtacac cgcgctggcc ttcgcggagt acgcgcgcct ctgcttccag     2040

gagctggggc accacgtgaa gctgtggatc accatgaacg aaccctacac gcgcaacatg     2100

acatacagcg cggggcacaa cctgctgaag gcacacgccc tcgcgtggca cgtctacaac     2160

gaaaagttcc ggcacgccca gaacggcaag atctccatcg ccctccaggc cgactggatc     2220

gagcctgcct gcccgttctc gcagaaggac aaagaggtgg ccgagcgggt gctggagttc     2280

gacatcggtt ggctggcgga gccgatcttc ggctccggcg actacccctg ggtcatgcgg     2340

gactggctga accagcgcaa caacttcttg cttccctact tcaccgaaga cgaaaagaag     2400

ctgatccagg gaaccttcga cttcctcgcc ctcagccact acaccaccat cttggtcgac     2460

tcggagaagg aggaccccat caagtacaac gattacctcg aggtccagga gatgacggac     2520

atcacgtggc tcaactcgcc gtcccaggtc gcggtggtcc cctggggcct gcggaaggtg     2580

ctcaactggc tgaagttcaa gtacggcgac ctccccatgt acatcatcag caacggaatc     2640

gacgacggcc tgcacgccga ggacgaccag ctccgtgtct actacatgca gaactacatc     2700

aacgaggccc tgaaggccca catcctggac ggcatcaacc tgtgtggtta cttcgcctac     2760

tcattcaacg accgcaccgc cccccggttc ggcctctaca ggtacgcggc ggaccagttc     2820

gagcccaagg cgtcgatgaa gcactaccgc aagatcatcg acagcaacgg cttccccggc     2880

ccggagaccc tcgaacgctt ctgccccgag gagttcacgg tgtgcaccga gtgcagcttc     2940

ttccacaccc gcaagtcggg cgggggcggc agcggcggcg gcggctcgga caagacccac     3000

acctgtcccc cctgccccgc ccccgagctg ctgggtggcc cgtccgtctt cctgttcccc     3060

ccgaagccga aggacactct catgatctcc cggacccccg aggtcacctg cgtggtcgta     3120

gacgtgtccc acgaggaccc ggaggtgaag ttcaactggt acgtggacgg cgtggaagtc     3180

cacaacgcca agaccaagcc gcgcgaagag cagtacaact cgacctaccg ggtcgtcagc     3240

gtcctcacgg tcctgcacca ggactggctc aatgggaagg aatacaagtg caaggtgtcc     3300

aacaaggcgc tgcccgcccc catcgagaag accatcagca aggccaaggg gcagccgcgg     3360

gaaccgcagg tctacacgct cccgcccagc cgggacgagc tcaccaagaa tcaggtcagt     3420

ctgacctgcc tggtgaaggg cttctacccg agtgacatcg ccgtggagtg ggagtcgaat     3480

ggccagcccg agaacaacta caagacaacg ccccccgtcc tggactccga cggctccttc     3540

ttcctgtact cgaagctcac ggtcgacaag agccggtggc agcagggcaa cgtgttcagc     3600

tgcagcgtca tgcacgaggc cctgcacaac cactacacgc agaagagcct gtcgctgtcc     3660

ccgggaaagt gataatctag agt                                             3683


<210>  147
<211>  2945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LubSP_Seq4_Sc

<400>  147
aagcttaccg ccaccatggc ctggaagact ctccccatct acctcctgct gctcctgtcg       60

gtcttcgtca tccagcaggt gtcctccgag ccgggcgacg gcgcgcagac ctgggcgcgc      120

ttcagccggc cgccggcccc ggaggcagcc ggcctgttcc aggggacctt cccggacggc      180

ttcctctggg ccgtcggctc ggccgcctac cagaccgagg gtggctggca gcagcacggc      240

aagggcgcct ccatctggga caccttcacc caccacccgc tggccccgcc gggcgactcc      300

cgcaacgcct ccctgccgct gggcgccccc tcgcccctgc agccggccac cggcgacgtg      360

gcgtcggaca gctacaacaa cgtgttccgc gacaccgaag ccctgcggga gctgggcgtc      420

acccactacc gcttctccat cagctgggct agggtcctgc ccaacggcag cgcgggcgtg      480

cccaaccgcg agggcctgcg ttactaccgg cgcctgctgg agcgcctgcg cgaactcggg      540

gtccagccgg tcgtcaccct ctaccactgg gatctgcccc agcgccttca ggacgcctac      600

ggcggctggg ccaaccgggc cctggccgac cacttccgcg actacgccga gctctgcttc      660

cgccactttg gcggccaggt caagtactgg atcaccatcg acaacccgta cgtcgtcgcc      720

tggcacggct acgcaaccgg ccggctggcc ccgggcatcc gcggctcccc ccgcctgggc      780

tacctcgtgg cgcacaacct cctgctggcc cacgccaagg tgtggcacct gtacaacacc      840

tccttccgcc cgacccaagg cggccaggtg tccatcgccc tgtccagcca ctggatcaac      900

ccccggcgca tgacggacca ctcgatcaag gagtgccaga agagcctcga cttcgtgctg      960

ggctggttcg cgaagccggt gttcatcgac ggtgactacc cggagtccat gaagaacaac     1020

ctgtcctcga tcctgcccga cttcaccgag agtgagaaga agttcatcaa gggcaccgcc     1080

gacttcttcg cgctctgctt cggccccacc ctctcgttcc agctgctgga cccccacatg     1140

aagttccggc agctggagag cccgaacctg cgccagctcc tgagctggat cgacctcgag     1200

ttcaatcacc cccagatctt catcgtggag aacggttggt tcgtgagcgg caccaccaag     1260

cgcgacgacg ccaaatacat gtactacctg aagaagttta tcatggagac cctgaaggcg     1320

atcaagctgg acggcgtcga cgtgatcggc tacaccgcct ggtccctgat ggacggcttc     1380

gagtggcacc gggggtacag catccggcgg ggcctgttct acgtggactt cctgtcgcag     1440

gacaagatgt tgctgcccaa gtcgtcggcc ctcttctacc agaagctgat cgagaagaac     1500

ggcttcccgc cgctgcccga gaaccagccc ctggagggca ccttcccgtg cgacttcgcc     1560

tggggcgtcg tggacaacta catccaggtc gacaccaccc tgagccagtt cacagacctc     1620

aacgtgtacc tctgggacgt gcaccacagc aaacgcctca tcaaggtcga cggcgtagtc     1680

accaagaagc ggaagagcta ttgcgtggac ttcgccgcga ttcaacccca aatcgcgctc     1740

ctccaggaga tgcacgtcac ccacttcagg ttcagcctcg actgggcgct gatcctgccg     1800

ctcgggaacc agtcgcaggt gaaccacacg atcctgcaat actacaggtg catggcgtcg     1860

gagctcgtcc gggtcaacat cacccccgtg gtcgccctct ggcagcccat ggcgcccaac     1920

cagggcctgc cccgcctcct ggcccgccag ggcgcctggg agaacccgta caccgcgctg     1980

gccttcgcgg agtacgcgcg cctctgcttc caggagctgg ggcaccacgt gaagctgtgg     2040

atcaccatga acgaacccta cacgcgcaac atgacataca gcgcggggca caacctgctg     2100

aaggcacacg ccctcgcgtg gcacgtctac aacgaaaagt tccggcacgc ccagaacggc     2160

aagatctcca tcgccctcca ggccgactgg atcgagcctg cctgcccgtt ctcgcagaag     2220

gacaaagagg tggccgagcg ggtgctggag ttcgacatcg gttggctggc ggagccgatc     2280

ttcggctccg gcgactaccc ctgggtcatg cgggactggc tgaaccagcg caacaacttc     2340

ttgcttccct acttcaccga agacgaaaag aagctgatcc agggaacctt cgacttcctc     2400

gccctcagcc actacaccac catcttggtc gactcggaga aggaggaccc catcaagtac     2460

aacgattacc tcgaggtcca ggagatgacg gacatcacgt ggctcaactc gccgtcccag     2520

gtcgcggtgg tcccctgggg cctgcggaag gtgctcaact ggctgaagtt caagtacggc     2580

gacctcccca tgtacatcat cagcaacgga atcgacgacg gcctgcacgc cgaggacgac     2640

cagctccgtg tctactacat gcagaactac atcaacgagg ccctgaaggc ccacatcctg     2700

gacggcatca acctgtgtgg ttacttcgcc tactcattca acgaccgcac cgccccccgg     2760

ttcggcctct acaggtacgc ggcggaccag ttcgagccca aggcgtcgat gaagcactac     2820

cgcaagatca tcgacagcaa cggcttcccc ggcccggaga ccctcgaacg cttctgcccc     2880

gaggagttca cggtgtgcac cgagtgcagc ttcttccaca cccgcaagtc gtgataatct     2940

agagt                                                                 2945


<210>  148
<211>  2360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LubSP_Seq5_Sc

<400>  148
aagcttaccg ccaccatggc ctggaagact ctccccatct acctcctgct gctcctgtcg       60

gtcttcgtca tccagcaggt gtcctccgag ccgggcgacg gggcccagac ctgggcccgc      120

ttcagcaggc ccccggcccc cgaggcggcg ggtctgttcc aggggacctt cccggacggt      180

ttcctgtggg ccgtcggctc cgccgcgtac cagacggagg gcgggtggca acaacacggg      240

aagggcgcgt cgatctggga cactttcacc caccaccccc tggccccccc gggggactcg      300

cggaacgcga gcctcccgct gggcgccccc agccccctcc agccggccac cggcgacgtg      360

gcgagcgaca gctacaacaa tgtcttcagg gacaccgagg ccctccggga actcggcgtc      420

acgcactacc gcttcagcat cagctgggcg cgggtcctgc cgaacggctc cgccggcgtg      480

ccgaaccgag agggcctgag gtactacagg cgcctcctgg agaggctccg ggagctgggc      540

gtacagcccg tcgtcaccct ctaccactgg gacctcccgc agcgcctgca ggacgcgtac      600

ggggggtggg ccaaccgcgc cctggccgac cacttccggg actacgccga gctctgcttc      660

cgccacttcg ggggccaggt caagtactgg atcaccatcg acaaccccta cgtcgtggcc      720

tggcacggct acgccaccgg tcgcctggcc ccgggcatcc ggggctcccc gcggctgggc      780

tacctcgtcg cgcataacct gctgctcgcg cacgcgaagg tctggcacct ctacaacacc      840

agcttccggc cgacccaggg cggccaggtg agcatcgcgc tgtcgagcca ctggatcaac      900

ccccgccgta tgactgacca ctcgatcaag gaatgccaga agagcctgga cttcgtcctg      960

gggtggttcg ccaagccggt gttcatcgac ggtgactacc cggaatcgat gaagaacaac     1020

ctgtcctcga tcctgcccga cttcaccgag tccgagaaga agttcattaa gggcaccgcc     1080

gacttcttcg cgctgtgctt cgggcccacc ctgtccttcc agctgctgga cccccacatg     1140

aagttccgcc agctagagtc tccgaacctg cgccagctcc tgtcgtggat cgacctggag     1200

ttcaaccacc cgcagatctt catcgtcgag aacggctggt tcgtctcggg gaccaccaaa     1260

cgggacgacg ccaagtatat gtactacctc aagaagttca tcatggagac cctgaaggcg     1320

atcaagctgg acggggtcga cgtcatcggg tacaccgcct ggtccctgat ggacggcttc     1380

gagtggcacc gcggctactc gatcagacgc ggcctgttct acgtcgactt cctgtcgcag     1440

gacaagatgc tcctgccgaa gtccagcgcg ctcttctacc agaagctgat cgagaagaac     1500

ggcttcccac cgctgcccga gaaccagcca ctcgaaggca ccttcccgtg cgacttcgcc     1560

tggggcgtcg tggacaacta catccaggtg tcgcagctca cgaagccgat ctcctcgctc     1620

accaagccgt accacggggg cggcggtagc ggcggcggcg gctccgacaa gacccacacc     1680

tgcccgccgt gccccgcgcc cgagctgctc ggcggcccct ccgtcttcct gttccctccc     1740

aagcccaagg acacgctgat gatctcccgg acccccgagg tcacctgcgt cgtggtcgac     1800

gtgtcgcacg aggacccgga ggtgaagttc aactggtacg tggacggtgt ggaggtgcat     1860

aacgccaaga ccaagccgcg ggaagagcag tacaactcca cgtacagggt cgtctcggtg     1920

ctgacggtcc tgcaccaaga ctggctgaac ggcaaggagt acaagtgcaa ggtgagcaac     1980

aaggccctcc cggcgcccat cgagaagacc atcagcaagg cgaagggcca gccgcgggag     2040

ccgcaggtct acaccctccc gccgagccgt gacgaactga ccaagaacca ggtctcgctc     2100

acgtgcctgg tcaaggggtt ctacccgagc gacatcgccg tggagtggga atcgaacggc     2160

cagccggaga acaactacaa gaccaccccg cccgtgctgg acagcgacgg ctccttcttc     2220

ctctactcca agctgaccgt cgacaagtcg cgctggcagc aagggaacgt gttctcctgc     2280

tcggtcatgc acgaggccct gcacaaccac tatacccaaa agagtctgtc gctgtccccg     2340

gggaagtgat aatctagagt                                                 2360


<210>  149
<211>  3683
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wtSP_Seq1_Sc

<400>  149
aagcttaccg ccaccatgcc cgcctccgcg cccccccgcc gcccgcgtcc tcccccgccg       60

agcctctccc tgctgctggt gctcctgggc ctgggcggac gccggctccg cgccgagccg      120

ggcgacggcg cgcagacctg ggcgcgcgtg agccggccgc cggccccgga ggcagccggc      180

ctgttccagg ggaccttccc ggacggcttc ctctgggccg tcggctcggc cgcctaccag      240

accgagggtg gctggcagca gcacggcaag ggcgcctcca tctgggacac cttcacccac      300

cacccgctgg ccccgccggg cgactcccgc aacgcctccc tgccgctggg cgccccctcg      360

cccctgcagc cggccaccgg cgacgtggcg tcggacagct acaacaacgt gttccgcgac      420

accgaagccc tgcgggagct gggcgtcacc cactaccgct tctccatcag ctgggctagg      480

gtcctgccca acggcagcgc gggcgtgccc aaccgcgagg gcctgcgtta ctaccggcgc      540

ctgctggagc gcctgcgcga actcggggtc cagccggtcg tcaccctcta ccactgggat      600

ctgccccagc gccttcagga cgcctacggc ggctgggcca accgggccct ggccgaccac      660

ttccgcgact acgccgagct ctgcttccgc cactttggcg gccaggtcaa gtactggatc      720

accatcgaca acccgtacgt cgtcgcctgg cacggctacg caaccggccg gctggccccg      780

ggcatccgcg gctccccccg cctgggctac ctcgtggcgc acaacctcct gctggcccac      840

gccaaggtgt ggcacctgta caacacctcc ttccgcccga cccaaggcgg ccaggtgtcc      900

atcgccctgt ccagccactg gatcaacccc cggcgcatga cggaccactc gatcaaggag      960

tgccagaaga gcctcgactt cgtgctgggc tggttcgcga agccggtgtt catcgacggt     1020

gactacccgg agtccatgaa gaacaacctg tcctcgatcc tgcccgactt caccgagagt     1080

gagaagaagt tcatcaaggg caccgccgac ttcttcgcgc tctgcttcgg ccccaccctc     1140

tcgttccagc tgctggaccc ccacatgaag ttccggcagc tggagagccc gaacctgcgc     1200

cagctcctga gctggatcga cctcgagttc aatcaccccc agatcttcat cgtggagaac     1260

ggttggttcg tgagcggcac caccaagcgc gacgacgcca aatacatgta ctacctgaag     1320

aagtttatca tggagaccct gaaggcgatc aagctggacg gcgtcgacgt gatcggctac     1380

accgcctggt ccctgatgga cggcttcgag tggcaccggg ggtacagcat ccggcggggc     1440

ctgttctacg tggacttcct gtcgcaggac aagatgttgc tgcccaagtc gtcggccctc     1500

ttctaccaga agctgatcga gaagaacggc ttcccgccgc tgcccgagaa ccagcccctg     1560

gagggcacct tcccgtgcga cttcgcctgg ggcgtcgtgg acaactacat ccaggtcgac     1620

accaccctga gccagttcac agacctcaac gtgtacctct gggacgtgca ccacagcaaa     1680

cgcctcatca aggtcgacgg cgtagtcacc aagaagcgga agagctattg cgtggacttc     1740

gccgcgattc aaccccaaat cgcgctcctc caggagatgc acgtcaccca cttcaggttc     1800

agcctcgact gggcgctgat cctgccgctc gggaaccagt cgcaggtgaa ccacacgatc     1860

ctgcaatact acaggtgcat ggcgtcggag ctcgtccggg tcaacatcac ccccgtggtc     1920

gccctctggc agcccatggc gcccaaccag ggcctgcccc gcctcctggc ccgccagggc     1980

gcctgggaga acccgtacac cgcgctggcc ttcgcggagt acgcgcgcct ctgcttccag     2040

gagctggggc accacgtgaa gctgtggatc accatgaacg aaccctacac gcgcaacatg     2100

acatacagcg cggggcacaa cctgctgaag gcacacgccc tcgcgtggca cgtctacaac     2160

gaaaagttcc ggcacgccca gaacggcaag atctccatcg ccctccaggc cgactggatc     2220

gagcctgcct gcccgttctc gcagaaggac aaagaggtgg ccgagcgggt gctggagttc     2280

gacatcggtt ggctggcgga gccgatcttc ggctccggcg actacccctg ggtcatgcgg     2340

gactggctga accagcgcaa caacttcttg cttccctact tcaccgaaga cgaaaagaag     2400

ctgatccagg gaaccttcga cttcctcgcc ctcagccact acaccaccat cttggtcgac     2460

tcggagaagg aggaccccat caagtacaac gattacctcg aggtccagga gatgacggac     2520

atcacgtggc tcaactcgcc gtcccaggtc gcggtggtcc cctggggcct gcggaaggtg     2580

ctcaactggc tgaagttcaa gtacggcgac ctccccatgt acatcatcag caacggaatc     2640

gacgacggcc tgcacgccga ggacgaccag ctccgtgtct actacatgca gaactacatc     2700

aacgaggccc tgaaggccca catcctggac ggcatcaacc tgtgtggtta cttcgcctac     2760

tcattcaacg accgcaccgc cccccggttc ggcctctaca ggtacgcggc ggaccagttc     2820

gagcccaagg cgtcgatgaa gcactaccgc aagatcatcg acagcaacgg cttccccggc     2880

ccggagaccc tcgaacgctt ctgccccgag gagttcacgg tgtgcaccga gtgcagcttc     2940

ttccacaccc gcaagtcggg cgggggcggc agcggcggcg gcggctcgga caagacccac     3000

acctgtcccc cctgccccgc ccccgagctg ctgggtggcc cgtccgtctt cctgttcccc     3060

ccgaagccga aggacactct catgatctcc cggacccccg aggtcacctg cgtggtcgta     3120

gacgtgtccc acgaggaccc ggaggtgaag ttcaactggt acgtggacgg cgtggaagtc     3180

cacaacgcca agaccaagcc gcgcgaagag cagtacaact cgacctaccg ggtcgtcagc     3240

gtcctcacgg tcctgcacca ggactggctc aatgggaagg aatacaagtg caaggtgtcc     3300

aacaaggcgc tgcccgcccc catcgagaag accatcagca aggccaaggg gcagccgcgg     3360

gaaccgcagg tctacacgct cccgcccagc cgggacgagc tcaccaagaa tcaggtcagt     3420

ctgacctgcc tggtgaaggg cttctacccg agtgacatcg ccgtggagtg ggagtcgaat     3480

ggccagcccg agaacaacta caagacaacg ccccccgtcc tggactccga cggctccttc     3540

ttcctgtact cgaagctcac ggtcgacaag agccggtggc agcagggcaa cgtgttcagc     3600

tgcagcgtca tgcacgaggc cctgcacaac cactacacgc agaagagcct gtcgctgtcc     3660

ccgggaaagt gataatctag agt                                             3683


<210>  150
<211>  1649
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LubSP_Seq6_Sc

<400>  150
aagcttaccg ccaccatggc ctggaagact ctccccatct acctcctgct gctcctgtcg       60

gtcttcgtca tccagcaggt gtcctccgag ccgggcgacg gggcccagac ctgggcccgc      120

ttcagcaggc ccccggcccc cgaggcggcg ggtctgttcc aggggacctt cccggacggt      180

ttcctgtggg ccgtcggctc cgccgcgtac cagacggagg gcgggtggca acaacacggg      240

aagggcgcgt cgatctggga cactttcacc caccaccccc tggccccccc gggggactcg      300

cggaacgcga gcctcccgct gggcgccccc agccccctcc agccggccac cggcgacgtg      360

gcgagcgaca gctacaacaa tgtcttcagg gacaccgagg ccctccggga actcggcgtc      420

acgcactacc gcttcagcat cagctgggcg cgggtcctgc cgaacggctc cgccggcgtg      480

ccgaaccgag agggcctgag gtactacagg cgcctcctgg agaggctccg ggagctgggc      540

gtacagcccg tcgtcaccct ctaccactgg gacctcccgc agcgcctgca ggacgcgtac      600

ggggggtggg ccaaccgcgc cctggccgac cacttccggg actacgccga gctctgcttc      660

cgccacttcg ggggccaggt caagtactgg atcaccatcg acaaccccta cgtcgtggcc      720

tggcacggct acgccaccgg tcgcctggcc ccgggcatcc ggggctcccc gcggctgggc      780

tacctcgtcg cgcataacct gctgctcgcg cacgcgaagg tctggcacct ctacaacacc      840

agcttccggc cgacccaggg cggccaggtg agcatcgcgc tgtcgagcca ctggatcaac      900

ccccgccgta tgactgacca ctcgatcaag gaatgccaga agagcctgga cttcgtcctg      960

gggtggttcg ccaagccggt gttcatcgac ggtgactacc cggaatcgat gaagaacaac     1020

ctgtcctcga tcctgcccga cttcaccgag tccgagaaga agttcattaa gggcaccgcc     1080

gacttcttcg cgctgtgctt cgggcccacc ctgtccttcc agctgctgga cccccacatg     1140

aagttccgcc agctagagtc tccgaacctg cgccagctcc tgtcgtggat cgacctggag     1200

ttcaaccacc cgcagatctt catcgtcgag aacggctggt tcgtctcggg gaccaccaaa     1260

cgggacgacg ccaagtatat gtactacctc aagaagttca tcatggagac cctgaaggcg     1320

atcaagctgg acggggtcga cgtcatcggg tacaccgcct ggtccctgat ggacggcttc     1380

gagtggcacc gcggctactc gatcagacgc ggcctgttct acgtcgactt cctgtcgcag     1440

gacaagatgc tcctgccgaa gtccagcgcg ctcttctacc agaagctgat cgagaagaac     1500

ggcttcccac cgctgcccga gaaccagcca ctcgaaggca ccttcccgtg cgacttcgcc     1560

tggggcgtcg tggacaacta catccaggtg tcgcagctca cgaagccgat ctcctcgctc     1620

accaagccgt accactgata atctagagt                                       1649


<210>  151
<211>  2972
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wtSP_Seq4_Sc

<400>  151
aagcttaccg ccaccatgcc cgcctccgcg cccccccgcc gcccgcgtcc tcccccgccg       60

agcctctccc tgctgctggt gctcctgggc ctgggcggac gccggctccg cgccgagccg      120

ggcgacggcg cgcagacctg ggcgcgcttc agccggccgc cggccccgga ggcagccggc      180

ctgttccagg ggaccttccc ggacggcttc ctctgggccg tcggctcggc cgcctaccag      240

accgagggtg gctggcagca gcacggcaag ggcgcctcca tctgggacac cttcacccac      300

cacccgctgg ccccgccggg cgactcccgc aacgcctccc tgccgctggg cgccccctcg      360

cccctgcagc cggccaccgg cgacgtggcg tcggacagct acaacaacgt gttccgcgac      420

accgaagccc tgcgggagct gggcgtcacc cactaccgct tctccatcag ctgggctagg      480

gtcctgccca acggcagcgc gggcgtgccc aaccgcgagg gcctgcgtta ctaccggcgc      540

ctgctggagc gcctgcgcga actcggggtc cagccggtcg tcaccctcta ccactgggat      600

ctgccccagc gccttcagga cgcctacggc ggctgggcca accgggccct ggccgaccac      660

ttccgcgact acgccgagct ctgcttccgc cactttggcg gccaggtcaa gtactggatc      720

accatcgaca acccgtacgt cgtcgcctgg cacggctacg caaccggccg gctggccccg      780

ggcatccgcg gctccccccg cctgggctac ctcgtggcgc acaacctcct gctggcccac      840

gccaaggtgt ggcacctgta caacacctcc ttccgcccga cccaaggcgg ccaggtgtcc      900

atcgccctgt ccagccactg gatcaacccc cggcgcatga cggaccactc gatcaaggag      960

tgccagaaga gcctcgactt cgtgctgggc tggttcgcga agccggtgtt catcgacggt     1020

gactacccgg agtccatgaa gaacaacctg tcctcgatcc tgcccgactt caccgagagt     1080

gagaagaagt tcatcaaggg caccgccgac ttcttcgcgc tctgcttcgg ccccaccctc     1140

tcgttccagc tgctggaccc ccacatgaag ttccggcagc tggagagccc gaacctgcgc     1200

cagctcctga gctggatcga cctcgagttc aatcaccccc agatcttcat cgtggagaac     1260

ggttggttcg tgagcggcac caccaagcgc gacgacgcca aatacatgta ctacctgaag     1320

aagtttatca tggagaccct gaaggcgatc aagctggacg gcgtcgacgt gatcggctac     1380

accgcctggt ccctgatgga cggcttcgag tggcaccggg ggtacagcat ccggcggggc     1440

ctgttctacg tggacttcct gtcgcaggac aagatgttgc tgcccaagtc gtcggccctc     1500

ttctaccaga agctgatcga gaagaacggc ttcccgccgc tgcccgagaa ccagcccctg     1560

gagggcacct tcccgtgcga cttcgcctgg ggcgtcgtgg acaactacat ccaggtcgac     1620

accaccctga gccagttcac agacctcaac gtgtacctct gggacgtgca ccacagcaaa     1680

cgcctcatca aggtcgacgg cgtagtcacc aagaagcgga agagctattg cgtggacttc     1740

gccgcgattc aaccccaaat cgcgctcctc caggagatgc acgtcaccca cttcaggttc     1800

agcctcgact gggcgctgat cctgccgctc gggaaccagt cgcaggtgaa ccacacgatc     1860

ctgcaatact acaggtgcat ggcgtcggag ctcgtccggg tcaacatcac ccccgtggtc     1920

gccctctggc agcccatggc gcccaaccag ggcctgcccc gcctcctggc ccgccagggc     1980

gcctgggaga acccgtacac cgcgctggcc ttcgcggagt acgcgcgcct ctgcttccag     2040

gagctggggc accacgtgaa gctgtggatc accatgaacg aaccctacac gcgcaacatg     2100

acatacagcg cggggcacaa cctgctgaag gcacacgccc tcgcgtggca cgtctacaac     2160

gaaaagttcc ggcacgccca gaacggcaag atctccatcg ccctccaggc cgactggatc     2220

gagcctgcct gcccgttctc gcagaaggac aaagaggtgg ccgagcgggt gctggagttc     2280

gacatcggtt ggctggcgga gccgatcttc ggctccggcg actacccctg ggtcatgcgg     2340

gactggctga accagcgcaa caacttcttg cttccctact tcaccgaaga cgaaaagaag     2400

ctgatccagg gaaccttcga cttcctcgcc ctcagccact acaccaccat cttggtcgac     2460

tcggagaagg aggaccccat caagtacaac gattacctcg aggtccagga gatgacggac     2520

atcacgtggc tcaactcgcc gtcccaggtc gcggtggtcc cctggggcct gcggaaggtg     2580

ctcaactggc tgaagttcaa gtacggcgac ctccccatgt acatcatcag caacggaatc     2640

gacgacggcc tgcacgccga ggacgaccag ctccgtgtct actacatgca gaactacatc     2700

aacgaggccc tgaaggccca catcctggac ggcatcaacc tgtgtggtta cttcgcctac     2760

tcattcaacg accgcaccgc cccccggttc ggcctctaca ggtacgcggc ggaccagttc     2820

gagcccaagg cgtcgatgaa gcactaccgc aagatcatcg acagcaacgg cttccccggc     2880

ccggagaccc tcgaacgctt ctgccccgag gagttcacgg tgtgcaccga gtgcagcttc     2940

ttccacaccc gcaagtcgtg ataatctaga gt                                   2972


<210>  152
<211>  1098
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protein_1_549_Variant

<400>  152

Met Pro Ala Ser Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser 
1               5                   10                  15      


Leu Ser Leu Leu Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg 
            20                  25                  30          


Ala Glu Pro Gly Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro 
        35                  40                  45              


Pro Ala Pro Glu Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly 
    50                  55                  60                  


Phe Leu Trp Ala Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp 
65                  70                  75                  80  


Gln Gln His Gly Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His 
                85                  90                  95      


Pro Leu Ala Pro Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly 
            100                 105                 110         


Ala Pro Ser Pro Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser 
        115                 120                 125             


Tyr Asn Asn Val Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val 
    130                 135                 140                 


Thr His Tyr Arg Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly 
145                 150                 155                 160 


Ser Ala Gly Val Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu 
                165                 170                 175     


Leu Glu Arg Leu Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr 
            180                 185                 190         


His Trp Asp Leu Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala 
        195                 200                 205             


Asn Arg Ala Leu Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe 
    210                 215                 220                 


Arg His Phe Gly Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro 
225                 230                 235                 240 


Tyr Val Val Ala Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly 
                245                 250                 255     


Ile Arg Gly Ser Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu 
            260                 265                 270         


Leu Ala His Ala Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro 
        275                 280                 285             


Thr Gln Gly Gly Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn 
    290                 295                 300                 


Pro Arg Arg Met Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu 
305                 310                 315                 320 


Asp Phe Val Leu Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp 
                325                 330                 335     


Tyr Pro Glu Ser Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe 
            340                 345                 350         


Thr Glu Ser Glu Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala 
        355                 360                 365             


Leu Cys Phe Gly Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met 
    370                 375                 380                 


Lys Phe Arg Gln Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp 
385                 390                 395                 400 


Ile Asp Leu Glu Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly 
                405                 410                 415     


Trp Phe Val Ser Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr 
            420                 425                 430         


Tyr Leu Lys Lys Phe Ile Met Glu Thr Leu Lys Ala Met Pro Ala Ser 
        435                 440                 445             


Ala Pro Pro Arg Arg Pro Arg Pro Pro Pro Pro Ser Leu Ser Leu Leu 
    450                 455                 460                 


Leu Val Leu Leu Gly Leu Gly Gly Arg Arg Leu Arg Ala Glu Pro Gly 
465                 470                 475                 480 


Asp Gly Ala Gln Thr Trp Ala Arg Phe Ser Arg Pro Pro Ala Pro Glu 
                485                 490                 495     


Ala Ala Gly Leu Phe Gln Gly Thr Phe Pro Asp Gly Phe Leu Trp Ala 
            500                 505                 510         


Val Gly Ser Ala Ala Tyr Gln Thr Glu Gly Gly Trp Gln Gln His Gly 
        515                 520                 525             


Lys Gly Ala Ser Ile Trp Asp Thr Phe Thr His His Pro Leu Ala Pro 
    530                 535                 540                 


Pro Gly Asp Ser Arg Asn Ala Ser Leu Pro Leu Gly Ala Pro Ser Pro 
545                 550                 555                 560 


Leu Gln Pro Ala Thr Gly Asp Val Ala Ser Asp Ser Tyr Asn Asn Val 
                565                 570                 575     


Phe Arg Asp Thr Glu Ala Leu Arg Glu Leu Gly Val Thr His Tyr Arg 
            580                 585                 590         


Phe Ser Ile Ser Trp Ala Arg Val Leu Pro Asn Gly Ser Ala Gly Val 
        595                 600                 605             


Pro Asn Arg Glu Gly Leu Arg Tyr Tyr Arg Arg Leu Leu Glu Arg Leu 
    610                 615                 620                 


Arg Glu Leu Gly Val Gln Pro Val Val Thr Leu Tyr His Trp Asp Leu 
625                 630                 635                 640 


Pro Gln Arg Leu Gln Asp Ala Tyr Gly Gly Trp Ala Asn Arg Ala Leu 
                645                 650                 655     


Ala Asp His Phe Arg Asp Tyr Ala Glu Leu Cys Phe Arg His Phe Gly 
            660                 665                 670         


Gly Gln Val Lys Tyr Trp Ile Thr Ile Asp Asn Pro Tyr Val Val Ala 
        675                 680                 685             


Trp His Gly Tyr Ala Thr Gly Arg Leu Ala Pro Gly Ile Arg Gly Ser 
    690                 695                 700                 


Pro Arg Leu Gly Tyr Leu Val Ala His Asn Leu Leu Leu Ala His Ala 
705                 710                 715                 720 


Lys Val Trp His Leu Tyr Asn Thr Ser Phe Arg Pro Thr Gln Gly Gly 
                725                 730                 735     


Gln Val Ser Ile Ala Leu Ser Ser His Trp Ile Asn Pro Arg Arg Met 
            740                 745                 750         


Thr Asp His Ser Ile Lys Glu Cys Gln Lys Ser Leu Asp Phe Val Leu 
        755                 760                 765             


Gly Trp Phe Ala Lys Pro Val Phe Ile Asp Gly Asp Tyr Pro Glu Ser 
    770                 775                 780                 


Met Lys Asn Asn Leu Ser Ser Ile Leu Pro Asp Phe Thr Glu Ser Glu 
785                 790                 795                 800 


Lys Lys Phe Ile Lys Gly Thr Ala Asp Phe Phe Ala Leu Cys Phe Gly 
                805                 810                 815     


Pro Thr Leu Ser Phe Gln Leu Leu Asp Pro His Met Lys Phe Arg Gln 
            820                 825                 830         


Leu Glu Ser Pro Asn Leu Arg Gln Leu Leu Ser Trp Ile Asp Leu Glu 
        835                 840                 845             


Phe Asn His Pro Gln Ile Phe Ile Val Glu Asn Gly Trp Phe Val Ser 
    850                 855                 860                 


Gly Thr Thr Lys Arg Asp Asp Ala Lys Tyr Met Tyr Tyr Leu Lys Lys 
865                 870                 875                 880 


Phe Ile Met Glu Thr Leu Lys Ala Ile Lys Leu Asp Gly Val Asp Val 
                885                 890                 895     


Ile Gly Tyr Thr Ala Trp Ser Leu Met Asp Gly Phe Glu Trp His Arg 
            900                 905                 910         


Gly Tyr Ser Ile Arg Arg Gly Leu Phe Tyr Val Asp Phe Leu Ser Gln 
        915                 920                 925             


Asp Lys Met Leu Leu Pro Lys Ser Ser Ala Leu Phe Tyr Gln Lys Leu 
    930                 935                 940                 


Ile Glu Lys Asn Gly Phe Pro Pro Leu Pro Glu Asn Gln Pro Leu Glu 
945                 950                 955                 960 


Gly Thr Phe Pro Cys Asp Phe Ala Trp Gly Val Val Asp Asn Tyr Ile 
                965                 970                 975     


Gln Val Ser Gln Leu Thr Lys Pro Ile Ser Ser Leu Thr Lys Pro Tyr 
            980                 985                 990         


His Ile Lys Leu Asp Gly Val Asp  Val Ile Gly Tyr Thr  Ala Trp Ser 
        995                 1000                 1005             


Leu Met  Asp Gly Phe Glu Trp  His Arg Gly Tyr Ser  Ile Arg Arg 
    1010                 1015                 1020             


Gly Leu  Phe Tyr Val Asp Phe  Leu Ser Gln Asp Lys  Met Leu Leu 
    1025                 1030                 1035             


Pro Lys  Ser Ser Ala Leu Phe  Tyr Gln Lys Leu Ile  Glu Lys Asn 
    1040                 1045                 1050             


Gly Phe  Pro Pro Leu Pro Glu  Asn Gln Pro Leu Glu  Gly Thr Phe 
    1055                 1060                 1065             


Pro Cys  Asp Phe Ala Trp Gly  Val Val Asp Asn Tyr  Ile Gln Val 
    1070                 1075                 1080             


Ser Gln  Leu Thr Lys Pro Ile  Ser Ser Leu Thr Lys  Pro Tyr His 
    1085                 1090                 1095             



