                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Craik, Charles S
       Harel, Efrat
       Rabuka, David
       Drake, Penelope M
       McFarland, Jesse M
 
<120>  ANTI-UPAR ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF

<130>  UCSF-558WO

<140>  PCT/US18/64124
<141>  2018-12-05

<150>  US 62/596,010
<151>  2017-12-07

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  281
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  1

Leu Arg Cys Met Gln Cys Lys Thr Asn Gly Asp Cys Arg Val Glu Glu 
1               5                   10                  15      


Cys Ala Leu Gly Gln Asp Leu Cys Arg Thr Thr Ile Val Arg Leu Trp 
            20                  25                  30          


Glu Glu Gly Glu Glu Leu Glu Leu Val Glu Lys Ser Cys Thr His Ser 
        35                  40                  45              


Glu Lys Thr Asn Arg Thr Leu Ser Tyr Arg Thr Gly Leu Lys Ile Thr 
    50                  55                  60                  


Ser Leu Thr Glu Val Val Cys Gly Leu Asp Leu Cys Asn Gln Gly Asn 
65                  70                  75                  80  


Ser Gly Arg Ala Val Thr Tyr Ser Arg Ser Arg Tyr Leu Glu Cys Ile 
                85                  90                  95      


Ser Cys Gly Ser Ser Asp Met Ser Cys Glu Arg Gly Arg His Gln Ser 
            100                 105                 110         


Leu Gln Cys Arg Ser Pro Glu Glu Gln Cys Leu Asp Val Val Thr His 
        115                 120                 125             


Trp Ile Gln Glu Gly Glu Glu Gly Arg Pro Lys Asp Asp Arg His Leu 
    130                 135                 140                 


Arg Gly Cys Gly Tyr Leu Pro Gly Cys Pro Gly Ser Asn Gly Phe His 
145                 150                 155                 160 


Asn Asn Asp Thr Phe His Phe Leu Lys Cys Cys Asn Thr Thr Lys Cys 
                165                 170                 175     


Asn Glu Gly Pro Ile Leu Glu Leu Glu Asn Leu Pro Gln Asn Gly Arg 
            180                 185                 190         


Gln Cys Tyr Ser Cys Lys Gly Asn Ser Thr His Gly Cys Ser Ser Glu 
        195                 200                 205             


Glu Thr Phe Leu Ile Asp Cys Arg Gly Pro Met Asn Gln Cys Leu Val 
    210                 215                 220                 


Ala Thr Gly Thr His Glu Pro Lys Asn Gln Ser Tyr Met Val Arg Gly 
225                 230                 235                 240 


Cys Ala Thr Ala Ser Met Cys Gln His Ala His Leu Gly Asp Ala Phe 
                245                 250                 255     


Ser Met Asn His Ile Asp Val Ser Cys Cys Thr Lys Ser Gly Cys Asn 
            260                 265                 270         


His Pro Asp Leu Asp Val Gln Tyr Arg 
        275                 280     


<210>  2
<211>  227
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  2

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Ser Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Ile Ile Asn Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Gln Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Asp Pro Gly Gly Pro Leu Asp Asp Ser Phe Asp 
            100                 105                 110         


Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys 
225         


<210>  3
<211>  220
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  3

Leu Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro 
1               5                   10                  15      


Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Arg 
            20                  25                  30          


Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Ile Arg Ala Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg 
65                  70                  75                  80  


Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln 
                85                  90                  95      


Ala Leu Gln Thr Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  4
<211>  220
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Arg Arg Phe Gly Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220 


<210>  5
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5

Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Pro Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Ser Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  6
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6

Gly Gly Asn Asn Ile Gly Ser Lys Ser Val His 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7

Asp Asp Ser Asp Arg Pro Pro 
1               5           


<210>  8
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  8

Gln Val Trp Asp Ser Ser Ser Asp His Ser Pro 
1               5                   10      


<210>  9
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9

Arg Ser Ser Gln Ser Leu Leu Arg Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  10
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10

Leu Gly Ser Ile Arg Ala Ser 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  11

Met Gln Ala Leu Gln Thr Pro Phe Thr 
1               5                   


<210>  12
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  12

Gly Gly Ser Phe Ser Gly Tyr Tyr Trp Ser Trp 
1               5                   10      


<210>  13
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  13

Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  14
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  14

Gly Arg Arg Phe Gly Asp Phe Asp Tyr 
1               5                   


<210>  15
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  15

Gly Asp Ser Val Ser Ser Asn Ser Ala Ala Trp Asn 
1               5                   10          


<210>  16
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  16

Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val 
1               5                   10                  15      


Lys Ser 
        


<210>  17
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  17

Asp Pro Gly Gly Pro Leu Asp Asp Ser Phe Asp Ile 
1               5                   10          


<210>  18
<211>  681
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  18
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc       60

acctgtgcca tctccgggga cagtgtctct agcaacagtg ctgcttggaa ctggatcagg      120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat      180

aatgattatg cagtatccgt gaaaagtcga ataattatca acccagacac atccaagaac      240

cagttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca      300

agagatccgg gggggcctct cgatgatagt tttgatatct ggggccaagg gacaatggtc      360

accgtctcaa gcgcctccac caagggccca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tccacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtagtga ccgtgccctc cagcagcttg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

aaagttgagc ccaaatcttg t                                                681


<210>  19
<211>  660
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  19
cttgatgttg tgatgactca gtctccactc tccctgcccg tcacccctgg agagccggcc       60

tccatctcct gcaggtctag tcagagcctc ctgcgtagta atggatacaa ctatttggat      120

tggtacctgc agaagccagg gcagtctcca cagctcctga tctatttggg ttctattcgg      180

gcctccgggg tccctgacag gttcagtggc agtggatcgg gcacagattt tacactgaga      240

attagcagag tggaggctga ggatgttggg gtttattact gcatgcaagc tctacaaacc      300

ccgttcactt ttggccaggg gaccaagctg gagatcaagc gaactgtggc tgcaccatct      360

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc      420

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc      480

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc      540

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc      600

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt      660


<210>  20
<211>  660
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  20
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc       60

acctgcgctg tctatggtgg gtccttcagt ggttactact ggagctggat ccgccagccc      120

ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac      180

ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg      240

aagctgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggcagaagg      300

ttcggggatt ttgactactg gggccaggga accctggtca ccgtctcaag cgcctccacc      360

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg      420

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca      480

ggcgccctga ccagcggcgt ccacaccttc ccggctgtcc tacagtcctc aggactctac      540

tccctcagca gcgtagtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc      600

aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt      660


<210>  21
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  21
cagcctgtgc tgactcagcc cccctcggtg tcagtggccc caggaaagac ggccaggatt       60

acctgtgggg gaaacaacat tggaagtaaa agtgtgcact ggtaccagca gaagccaggc      120

caggcccctg tgctggtcgt ctatgatgat agcgaccggc ccccagggat ccctgagcga      180

ttctctggct ccaattctgg gaacacggcc accctgacca tcagcagggt cgaagccggg      240

gatgaggccg actattactg tcaggtgtgg gatagtagta gtgatcactc ccccttcgga      300

actgggacca aggtcaccgt cctaggtcag cccaaggcca accccactgt cactctgttc      360

ccgccctcct ctgaggagct ccaagccaac aaggccacac tagtgtgtct gatcagtgac      420

ttctacccgg gagctgtgac agtggcctgg aaggcagatg gcagccccgt caaggcggga      480

gtggagacca ccaaaccctc caaacagagc aacaacaagt acgcggccag cagctacctg      540

agcctgacgc ccgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgct ct                         642


<210>  22
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  22

Leu Cys Thr Pro Ser Arg 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  23

Met Cys Thr Pro Ser Arg 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  24

Val Cys Thr Pro Ser Arg 
1               5       


<210>  25
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  25

Leu Cys Ser Pro Ser Arg 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  26

Leu Cys Ala Pro Ser Arg 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  27

Leu Cys Val Pro Ser Arg 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  28

Leu Cys Gly Pro Ser Arg 
1               5       


<210>  29
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  29

Ile Cys Thr Pro Ala Arg 
1               5       


<210>  30
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  30

Leu Cys Thr Pro Ser Lys 
1               5       


<210>  31
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  31

Met Cys Thr Pro Ser Lys 
1               5       


<210>  32
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  32

Val Cys Thr Pro Ser Lys 
1               5       


<210>  33
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  33

Leu Cys Ser Pro Ser Lys 
1               5       


<210>  34
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  34

Leu Cys Ala Pro Ser Lys 
1               5       


<210>  35
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  35

Leu Cys Val Pro Ser Lys 
1               5       


<210>  36
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  36

Leu Cys Gly Pro Ser Lys 
1               5       


<210>  37
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  37

Leu Cys Thr Pro Ser Ala 
1               5       


<210>  38
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  38

Ile Cys Thr Pro Ala Ala 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  39

Met Cys Thr Pro Ser Ala 
1               5       


<210>  40
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  40

Val Cys Thr Pro Ser Ala 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  41

Leu Cys Ser Pro Ser Ala 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  42

Leu Cys Ala Pro Ser Ala 
1               5       


<210>  43
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  43

Leu Cys Val Pro Ser Ala 
1               5       


<210>  44
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  44

Leu Cys Gly Pro Ser Ala 
1               5       


<210>  45
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 may be present or absent and, when present, can
       be any amino acid, with the proviso that when the sequence is at 
       the N-terminus of the conjugate, Xaa is present

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is a modified amino acid residue of formula (I)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is proline or alanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is a basic amino acid or an aliphatic amino 
       acid

<400>  45

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  46
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is the modified amino acid residue of formula 
       (I)

<400>  46

Leu Xaa Thr Pro Ser Arg 
1               5       


<210>  47
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is the modified amino acid residue of formula 
       (I)

<400>  47

Ser Leu Ser Leu Ser Leu Gly Ser Leu Xaa Thr Pro Ser Arg Gly Ser 
1               5                   10                  15      


<210>  48
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is the modified amino acid residue of formula 
       (I)

<400>  48

Trp Asn Ser Gly Ala Leu Xaa Thr Pro Ser Arg Gly Val His Thr Phe 
1               5                   10                  15      


Pro Ala 
        


<210>  49
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  49

Ser Trp Asn Ser Gly Ala Leu Cys Thr Pro Ser Arg Gly Val His Thr 
1               5                   10                  15      


Phe Pro Ala 
            


<210>  50
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  50

Leu Cys Thr Pro Ser Arg 
1               5       


<210>  51
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 is present or absent and, when present, is any 
       amino acid, with the proviso that when the heterologous sulfatase
       motif is at an N-terminus of the polypeptide, Xaa is present

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 cysteine or serine

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is proline or alanine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is an aliphatic amino acid or a basic amino 
       acid

<400>  51

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  52
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 may be present or absent and, when present, can
       be any amino acid with the proviso that when the sulfatase motif 
       is at the N-terminus of the target polypeptide, Xaa is present

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is a basic amino acid or an aliphatic amino 
       acid

<400>  52

Xaa Cys Xaa Pro Xaa Glx 
1               5       


<210>  53
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 may be present or absent and, when present, can
       be any amino acid, with the proviso that when the sulfatase motif
       is at the N-terminus of the target polypeptide, Xaa is present

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is a formylglycine residue

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is either a proline or alanine residue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 may be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is a basic amino acid or an aliphatic amino 
       acid

<400>  53

Xaa Xaa Xaa Glx Xaa Glx 
1               5       


<210>  54
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 may be cysteine ro serine

<400>  54

Leu Xaa Thr Pro Ser Arg 
1               5       


<210>  55
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is 2-formylglycine

<400>  55

Leu Xaa Thr Pro Ser Arg 
1               5       


