                               SEQUENCE LISTING

<110> DISCERNDX, INC.
 
<120> ROBUST PANELS OF COLORECTAL CANCER BIOMARKERS

<130> 53897-761.601

<140> PCT/US2018/064107
<141> 2018-12-05

<150> 62/594,941
<151> 2017-12-05

<160> 71    

<170> PatentIn version 3.5

<210> 1
<211> 347
<212> PRT
<213> Homo sapiens

<400> 1
Met Ser Ser Trp Ser Arg Gln Arg Pro Lys Ser Pro Gly Gly Ile Gln 
1               5                   10                  15      


Pro His Val Ser Arg Thr Leu Phe Leu Leu Leu Leu Leu Ala Ala Ser 
            20                  25                  30          


Ala Trp Gly Val Thr Leu Ser Pro Lys Asp Cys Gln Val Phe Arg Ser 
        35                  40                  45              


Asp His Gly Ser Ser Ile Ser Cys Gln Pro Pro Ala Glu Ile Pro Gly 
    50                  55                  60                  


Tyr Leu Pro Ala Asp Thr Val His Leu Ala Val Glu Phe Phe Asn Leu 
65                  70                  75                  80  


Thr His Leu Pro Ala Asn Leu Leu Gln Gly Ala Ser Lys Leu Gln Glu 
                85                  90                  95      


Leu His Leu Ser Ser Asn Gly Leu Glu Ser Leu Ser Pro Glu Phe Leu 
            100                 105                 110         


Arg Pro Val Pro Gln Leu Arg Val Leu Asp Leu Thr Arg Asn Ala Leu 
        115                 120                 125             


Thr Gly Leu Pro Pro Gly Leu Phe Gln Ala Ser Ala Thr Leu Asp Thr 
    130                 135                 140                 


Leu Val Leu Lys Glu Asn Gln Leu Glu Val Leu Glu Val Ser Trp Leu 
145                 150                 155                 160 


His Gly Leu Lys Ala Leu Gly His Leu Asp Leu Ser Gly Asn Arg Leu 
                165                 170                 175     


Arg Lys Leu Pro Pro Gly Leu Leu Ala Asn Phe Thr Leu Leu Arg Thr 
            180                 185                 190         


Leu Asp Leu Gly Glu Asn Gln Leu Glu Thr Leu Pro Pro Asp Leu Leu 
        195                 200                 205             


Arg Gly Pro Leu Gln Leu Glu Arg Leu His Leu Glu Gly Asn Lys Leu 
    210                 215                 220                 


Gln Val Leu Gly Lys Asp Leu Leu Leu Pro Gln Pro Asp Leu Arg Tyr 
225                 230                 235                 240 


Leu Phe Leu Asn Gly Asn Lys Leu Ala Arg Val Ala Ala Gly Ala Phe 
                245                 250                 255     


Gln Gly Leu Arg Gln Leu Asp Met Leu Asp Leu Ser Asn Asn Ser Leu 
            260                 265                 270         


Ala Ser Val Pro Glu Gly Leu Trp Ala Ser Leu Gly Gln Pro Asn Trp 
        275                 280                 285             


Asp Met Arg Asp Gly Phe Asp Ile Ser Gly Asn Pro Trp Ile Cys Asp 
    290                 295                 300                 


Gln Asn Leu Ser Asp Leu Tyr Arg Trp Leu Gln Ala Gln Lys Asp Lys 
305                 310                 315                 320 


Met Phe Ser Gln Asn Asp Thr Arg Cys Ala Gly Pro Glu Ala Val Lys 
                325                 330                 335     


Gly Gln Thr Leu Leu Ala Val Ala Lys Ser Gln 
            340                 345         


<210> 2
<211> 375
<212> PRT
<213> Homo sapiens

<400> 2
Met Asp Asp Asp Thr Ala Val Leu Val Ile Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Gln Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Met Met Glu Gly Met His 
        35                  40                  45              


Gln Lys Glu Ser Tyr Val Gly Lys Glu Ala Gln Ser Lys Arg Gly Met 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Met Glu His Gly Ile Ile Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Ile Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Thr 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Phe Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Asn Ala Leu Pro His Ala Thr Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Glu Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Arg Phe Thr Thr Thr Ala Glu Gln Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Ser Glu 
    210                 215                 220                 


Gln Glu Met Ala Met Ala Ala Ser Ser Ser Ser Val Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Cys Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Lys Thr Thr Phe Asn Ser Ile Val Lys Ser Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Thr Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala His Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Ile Met Lys Ile Lys Ile Ile Ala Pro Pro Lys Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Val Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210> 3
<211> 605
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Leu Arg Lys Gly Gly Leu Ala Leu Ala Leu Leu Leu Leu Ser 
1               5                   10                  15      


Trp Val Ala Leu Gly Pro Arg Ser Leu Glu Gly Ala Asp Pro Gly Thr 
            20                  25                  30          


Pro Gly Glu Ala Glu Gly Pro Ala Cys Pro Ala Ala Cys Val Cys Ser 
        35                  40                  45              


Tyr Asp Asp Asp Ala Asp Glu Leu Ser Val Phe Cys Ser Ser Arg Asn 
    50                  55                  60                  


Leu Thr Arg Leu Pro Asp Gly Val Pro Gly Gly Thr Gln Ala Leu Trp 
65                  70                  75                  80  


Leu Asp Gly Asn Asn Leu Ser Ser Val Pro Pro Ala Ala Phe Gln Asn 
                85                  90                  95      


Leu Ser Ser Leu Gly Phe Leu Asn Leu Gln Gly Gly Gln Leu Gly Ser 
            100                 105                 110         


Leu Glu Pro Gln Ala Leu Leu Gly Leu Glu Asn Leu Cys His Leu His 
        115                 120                 125             


Leu Glu Arg Asn Gln Leu Arg Ser Leu Ala Leu Gly Thr Phe Ala His 
    130                 135                 140                 


Thr Pro Ala Leu Ala Ser Leu Gly Leu Ser Asn Asn Arg Leu Ser Arg 
145                 150                 155                 160 


Leu Glu Asp Gly Leu Phe Glu Gly Leu Gly Ser Leu Trp Asp Leu Asn 
                165                 170                 175     


Leu Gly Trp Asn Ser Leu Ala Val Leu Pro Asp Ala Ala Phe Arg Gly 
            180                 185                 190         


Leu Gly Ser Leu Arg Glu Leu Val Leu Ala Gly Asn Arg Leu Ala Tyr 
        195                 200                 205             


Leu Gln Pro Ala Leu Phe Ser Gly Leu Ala Glu Leu Arg Glu Leu Asp 
    210                 215                 220                 


Leu Ser Arg Asn Ala Leu Arg Ala Ile Lys Ala Asn Val Phe Val Gln 
225                 230                 235                 240 


Leu Pro Arg Leu Gln Lys Leu Tyr Leu Asp Arg Asn Leu Ile Ala Ala 
                245                 250                 255     


Val Ala Pro Gly Ala Phe Leu Gly Leu Lys Ala Leu Arg Trp Leu Asp 
            260                 265                 270         


Leu Ser His Asn Arg Val Ala Gly Leu Leu Glu Asp Thr Phe Pro Gly 
        275                 280                 285             


Leu Leu Gly Leu Arg Val Leu Arg Leu Ser His Asn Ala Ile Ala Ser 
    290                 295                 300                 


Leu Arg Pro Arg Thr Phe Lys Asp Leu His Phe Leu Glu Glu Leu Gln 
305                 310                 315                 320 


Leu Gly His Asn Arg Ile Arg Gln Leu Ala Glu Arg Ser Phe Glu Gly 
                325                 330                 335     


Leu Gly Gln Leu Glu Val Leu Thr Leu Asp His Asn Gln Leu Gln Glu 
            340                 345                 350         


Val Lys Ala Gly Ala Phe Leu Gly Leu Thr Asn Val Ala Val Met Asn 
        355                 360                 365             


Leu Ser Gly Asn Cys Leu Arg Asn Leu Pro Glu Gln Val Phe Arg Gly 
    370                 375                 380                 


Leu Gly Lys Leu His Ser Leu His Leu Glu Gly Ser Cys Leu Gly Arg 
385                 390                 395                 400 


Ile Arg Pro His Thr Phe Thr Gly Leu Ser Gly Leu Arg Arg Leu Phe 
                405                 410                 415     


Leu Lys Asp Asn Gly Leu Val Gly Ile Glu Glu Gln Ser Leu Trp Gly 
            420                 425                 430         


Leu Ala Glu Leu Leu Glu Leu Asp Leu Thr Ser Asn Gln Leu Thr His 
        435                 440                 445             


Leu Pro His Arg Leu Phe Gln Gly Leu Gly Lys Leu Glu Tyr Leu Leu 
    450                 455                 460                 


Leu Ser Arg Asn Arg Leu Ala Glu Leu Pro Ala Asp Ala Leu Gly Pro 
465                 470                 475                 480 


Leu Gln Arg Ala Phe Trp Leu Asp Val Ser His Asn Arg Leu Glu Ala 
                485                 490                 495     


Leu Pro Asn Ser Leu Leu Ala Pro Leu Gly Arg Leu Arg Tyr Leu Ser 
            500                 505                 510         


Leu Arg Asn Asn Ser Leu Arg Thr Phe Thr Pro Gln Pro Pro Gly Leu 
        515                 520                 525             


Glu Arg Leu Trp Leu Glu Gly Asn Pro Trp Asp Cys Gly Cys Pro Leu 
    530                 535                 540                 


Lys Ala Leu Arg Asp Phe Ala Leu Gln Asn Pro Ser Ala Val Pro Arg 
545                 550                 555                 560 


Phe Val Gln Ala Ile Cys Glu Gly Asp Asp Cys Gln Pro Pro Ala Tyr 
                565                 570                 575     


Thr Tyr Asn Asn Ile Thr Cys Ala Ser Pro Pro Glu Val Val Gly Leu 
            580                 585                 590         


Asp Leu Arg Asp Leu Ser Glu Ala His Phe Ala Pro Cys 
        595                 600                 605 


<210> 4
<211> 127
<212> PRT
<213> Homo sapiens

<400> 4
Met Ser Leu Leu Arg Asn Arg Leu Gln Ala Leu Pro Ala Leu Cys Leu 
1               5                   10                  15      


Cys Val Leu Val Leu Ala Cys Ile Gly Ala Cys Gln Pro Glu Ala Gln 
            20                  25                  30          


Glu Gly Thr Leu Ser Pro Pro Pro Lys Leu Lys Met Ser Arg Trp Ser 
        35                  40                  45              


Leu Val Arg Gly Arg Met Lys Glu Leu Leu Glu Thr Val Val Asn Arg 
    50                  55                  60                  


Thr Arg Asp Gly Trp Gln Trp Phe Trp Ser Pro Ser Thr Phe Arg Gly 
65                  70                  75                  80  


Phe Met Gln Thr Tyr Tyr Asp Asp His Leu Arg Asp Leu Gly Pro Leu 
                85                  90                  95      


Thr Lys Ala Trp Phe Leu Glu Ser Lys Asp Ser Leu Leu Lys Lys Thr 
            100                 105                 110         


His Ser Leu Cys Pro Arg Leu Val Cys Gly Asp Lys Asp Gln Gly 
        115                 120                 125         


<210> 5
<211> 317
<212> PRT
<213> Homo sapiens

<400> 5
Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Cys Gly Arg Leu Val Gln Tyr Arg Gly Glu Val Gln Ala Met Leu 
    130                 135                 140                 


Gly Gln Ser Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg 
145                 150                 155                 160 


Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Gln Lys Arg 
                165                 170                 175     


Leu Ala Val Tyr Gln Ala Gly Ala Arg Glu Gly Ala Glu Arg Gly Leu 
            180                 185                 190         


Ser Ala Ile Arg Glu Arg Leu Gly Pro Leu Val Glu Gln Gly Arg Val 
        195                 200                 205             


Arg Ala Ala Thr Val Gly Ser Leu Ala Gly Gln Pro Leu Gln Glu Arg 
    210                 215                 220                 


Ala Gln Ala Trp Gly Glu Arg Leu Arg Ala Arg Met Glu Glu Met Gly 
225                 230                 235                 240 


Ser Arg Thr Arg Asp Arg Leu Asp Glu Val Lys Glu Gln Val Ala Glu 
                245                 250                 255     


Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
            260                 265                 270         


Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
        275                 280                 285             


Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
    290                 295                 300                 


Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
305                 310                 315         


<210> 6
<211> 398
<212> PRT
<213> Homo sapiens

<400> 6
Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met 
1               5                   10                  15      


Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 
            20                  25                  30          


Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 
        35                  40                  45              


Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser 
    50                  55                  60                  


Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser 
65                  70                  75                  80  


Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly 
                85                  90                  95      


Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg 
            100                 105                 110         


Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn 
        115                 120                 125             


Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe 
    130                 135                 140                 


Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala 
145                 150                 155                 160 


Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala Asn 
                165                 170                 175     


Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr Leu Val 
            180                 185                 190         


Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu Val Leu Leu 
        195                 200                 205             


Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr Gly Ile Thr 
    210                 215                 220                 


Ser Ser Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr Gln Ala Gln Ala 
225                 230                 235                 240 


His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu Val Arg Glu 
                245                 250                 255     


Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn Thr 
            260                 265                 270         


Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg Arg 
        275                 280                 285             


Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser Arg Pro 
    290                 295                 300                 


Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg 
305                 310                 315                 320 


Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val Lys Leu Thr 
                325                 330                 335     


Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val Val Tyr Leu 
            340                 345                 350         


Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Glu Thr Ala 
        355                 360                 365             


Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn Ile 
    370                 375                 380                 


Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu 
385                 390                 395             


<210> 7
<211> 602
<212> PRT
<213> Homo sapiens

<400> 7
Met His Ser Lys Val Thr Ile Ile Cys Ile Arg Phe Leu Phe Trp Phe 
1               5                   10                  15      


Leu Leu Leu Cys Met Leu Ile Gly Lys Ser His Thr Glu Asp Asp Ile 
            20                  25                  30          


Ile Ile Ala Thr Lys Asn Gly Lys Val Arg Gly Met Asn Leu Thr Val 
        35                  40                  45              


Phe Gly Gly Thr Val Thr Ala Phe Leu Gly Ile Pro Tyr Ala Gln Pro 
    50                  55                  60                  


Pro Leu Gly Arg Leu Arg Phe Lys Lys Pro Gln Ser Leu Thr Lys Trp 
65                  70                  75                  80  


Ser Asp Ile Trp Asn Ala Thr Lys Tyr Ala Asn Ser Cys Cys Gln Asn 
                85                  90                  95      


Ile Asp Gln Ser Phe Pro Gly Phe His Gly Ser Glu Met Trp Asn Pro 
            100                 105                 110         


Asn Thr Asp Leu Ser Glu Asp Cys Leu Tyr Leu Asn Val Trp Ile Pro 
        115                 120                 125             


Ala Pro Lys Pro Lys Asn Ala Thr Val Leu Ile Trp Ile Tyr Gly Gly 
    130                 135                 140                 


Gly Phe Gln Thr Gly Thr Ser Ser Leu His Val Tyr Asp Gly Lys Phe 
145                 150                 155                 160 


Leu Ala Arg Val Glu Arg Val Ile Val Val Ser Met Asn Tyr Arg Val 
                165                 170                 175     


Gly Ala Leu Gly Phe Leu Ala Leu Pro Gly Asn Pro Glu Ala Pro Gly 
            180                 185                 190         


Asn Met Gly Leu Phe Asp Gln Gln Leu Ala Leu Gln Trp Val Gln Lys 
        195                 200                 205             


Asn Ile Ala Ala Phe Gly Gly Asn Pro Lys Ser Val Thr Leu Phe Gly 
    210                 215                 220                 


Glu Ser Ala Gly Ala Ala Ser Val Ser Leu His Leu Leu Ser Pro Gly 
225                 230                 235                 240 


Ser His Ser Leu Phe Thr Arg Ala Ile Leu Gln Ser Gly Ser Phe Asn 
                245                 250                 255     


Ala Pro Trp Ala Val Thr Ser Leu Tyr Glu Ala Arg Asn Arg Thr Leu 
            260                 265                 270         


Asn Leu Ala Lys Leu Thr Gly Cys Ser Arg Glu Asn Glu Thr Glu Ile 
        275                 280                 285             


Ile Lys Cys Leu Arg Asn Lys Asp Pro Gln Glu Ile Leu Leu Asn Glu 
    290                 295                 300                 


Ala Phe Val Val Pro Tyr Gly Thr Pro Leu Ser Val Asn Phe Gly Pro 
305                 310                 315                 320 


Thr Val Asp Gly Asp Phe Leu Thr Asp Met Pro Asp Ile Leu Leu Glu 
                325                 330                 335     


Leu Gly Gln Phe Lys Lys Thr Gln Ile Leu Val Gly Val Asn Lys Asp 
            340                 345                 350         


Glu Gly Thr Ala Phe Leu Val Tyr Gly Ala Pro Gly Phe Ser Lys Asp 
        355                 360                 365             


Asn Asn Ser Ile Ile Thr Arg Lys Glu Phe Gln Glu Gly Leu Lys Ile 
    370                 375                 380                 


Phe Phe Pro Gly Val Ser Glu Phe Gly Lys Glu Ser Ile Leu Phe His 
385                 390                 395                 400 


Tyr Thr Asp Trp Val Asp Asp Gln Arg Pro Glu Asn Tyr Arg Glu Ala 
                405                 410                 415     


Leu Gly Asp Val Val Gly Asp Tyr Asn Phe Ile Cys Pro Ala Leu Glu 
            420                 425                 430         


Phe Thr Lys Lys Phe Ser Glu Trp Gly Asn Asn Ala Phe Phe Tyr Tyr 
        435                 440                 445             


Phe Glu His Arg Ser Ser Lys Leu Pro Trp Pro Glu Trp Met Gly Val 
    450                 455                 460                 


Met His Gly Tyr Glu Ile Glu Phe Val Phe Gly Leu Pro Leu Glu Arg 
465                 470                 475                 480 


Arg Asp Asn Tyr Thr Lys Ala Glu Glu Ile Leu Ser Arg Ser Ile Val 
                485                 490                 495     


Lys Arg Trp Ala Asn Phe Ala Lys Tyr Gly Asn Pro Asn Glu Thr Gln 
            500                 505                 510         


Asn Asn Ser Thr Ser Trp Pro Val Phe Lys Ser Thr Glu Gln Lys Tyr 
        515                 520                 525             


Leu Thr Leu Asn Thr Glu Ser Thr Arg Ile Met Thr Lys Leu Arg Ala 
    530                 535                 540                 


Gln Gln Cys Arg Phe Trp Thr Ser Phe Phe Pro Lys Val Leu Glu Met 
545                 550                 555                 560 


Thr Gly Asn Ile Asp Glu Ala Glu Trp Glu Trp Lys Ala Gly Phe His 
                565                 570                 575     


Arg Trp Asn Asn Tyr Met Met Asp Trp Lys Asn Gln Phe Asn Asp Tyr 
            580                 585                 590         


Thr Ser Lys Lys Glu Ser Cys Val Gly Leu 
        595                 600         


<210> 8
<211> 782
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala Ala Thr Ala Ser Arg 
            20                  25                  30          


Gly Ala Ser Gln Ala Gly Ala Pro Gln Gly Arg Val Pro Glu Ala Arg 
        35                  40                  45              


Pro Asn Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys 
    50                  55                  60                  


Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro 
65                  70                  75                  80  


Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val 
                85                  90                  95      


Ile Leu Lys Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu 
            100                 105                 110         


His Tyr Trp Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala 
        115                 120                 125             


Ala Ile Phe Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val 
    130                 135                 140                 


Gln His Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr 
145                 150                 155                 160 


Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe 
                165                 170                 175     


Lys His Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val 
            180                 185                 190         


Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu 
        195                 200                 205             


Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile 
    210                 215                 220                 


His Gln Trp Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala 
225                 230                 235                 240 


Thr Gln Val Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala 
                245                 250                 255     


Arg Val His Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln 
            260                 265                 270         


Val Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala 
        275                 280                 285             


Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser 
    290                 295                 300                 


Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn Pro 
305                 310                 315                 320 


Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp His 
                325                 330                 335     


Gly Lys Asp Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn Thr 
            340                 345                 350         


Glu Glu Arg Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr Lys 
        355                 360                 365             


Met Asp Tyr Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly 
    370                 375                 380                 


Glu Thr Pro Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp 
385                 390                 395                 400 


Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn 
                405                 410                 415     


Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr Ala 
            420                 425                 430         


Met Ala Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys Gln 
        435                 440                 445             


Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala Thr 
    450                 455                 460                 


Tyr Gly Gln Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr 
465                 470                 475                 480 


Arg His Gly Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala 
                485                 490                 495     


Gln Ser Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln 
            500                 505                 510         


Leu Asp Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln 
        515                 520                 525             


Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met 
    530                 535                 540                 


Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro 
545                 550                 555                 560 


Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr 
                565                 570                 575     


Arg Ala Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp 
            580                 585                 590         


Ala Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr 
        595                 600                 605             


Gly Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val 
    610                 615                 620                 


Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly 
625                 630                 635                 640 


Phe Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg 
                645                 650                 655     


Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys 
            660                 665                 670         


Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu 
        675                 680                 685             


Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp 
    690                 695                 700                 


Asp Gln Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys 
705                 710                 715                 720 


Thr Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala 
                725                 730                 735     


Asn Arg Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu 
            740                 745                 750         


Pro Pro Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp 
        755                 760                 765             


Ser Val Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala 
    770                 775                 780         


<210> 9
<211> 578
<212> PRT
<213> Homo sapiens

<400> 9
Met Leu Pro Cys Leu Val Val Leu Leu Ala Ala Leu Leu Ser Leu Arg 
1               5                   10                  15      


Leu Gly Ser Asp Ala His Gly Thr Glu Leu Pro Ser Pro Pro Ser Val 
            20                  25                  30          


Trp Phe Glu Ala Glu Phe Phe His His Ile Leu His Trp Thr Pro Ile 
        35                  40                  45              


Pro Asn Gln Ser Glu Ser Thr Cys Tyr Glu Val Ala Leu Leu Arg Tyr 
    50                  55                  60                  


Gly Ile Glu Ser Trp Asn Ser Ile Ser Asn Cys Ser Gln Thr Leu Ser 
65                  70                  75                  80  


Tyr Asp Leu Thr Ala Val Thr Leu Asp Leu Tyr His Ser Asn Gly Tyr 
                85                  90                  95      


Arg Ala Arg Val Arg Ala Val Asp Gly Ser Arg His Ser Asn Trp Thr 
            100                 105                 110         


Val Thr Asn Thr Arg Phe Ser Val Asp Glu Val Thr Leu Thr Val Gly 
        115                 120                 125             


Ser Val Asn Leu Glu Ile His Asn Gly Phe Ile Leu Gly Lys Ile Gln 
    130                 135                 140                 


Leu Pro Arg Pro Lys Met Ala Pro Ala Asn Asp Thr Tyr Glu Ser Ile 
145                 150                 155                 160 


Phe Ser His Phe Arg Glu Tyr Glu Ile Ala Ile Arg Lys Val Pro Gly 
                165                 170                 175     


Asn Phe Thr Phe Thr His Lys Lys Val Lys His Glu Asn Phe Ser Leu 
            180                 185                 190         


Leu Thr Ser Gly Glu Val Gly Glu Phe Cys Val Gln Val Lys Pro Ser 
        195                 200                 205             


Val Ala Ser Arg Ser Asn Lys Gly Met Trp Ser Lys Glu Glu Cys Ile 
    210                 215                 220                 


Ser Leu Thr Arg Gln Tyr Phe Thr Val Thr Asn Val Ile Ile Phe Phe 
225                 230                 235                 240 


Ala Phe Val Leu Leu Leu Ser Gly Ala Leu Ala Tyr Cys Leu Ala Leu 
                245                 250                 255     


Gln Leu Tyr Val Arg Arg Arg Lys Lys Leu Pro Ser Val Leu Leu Phe 
            260                 265                 270         


Lys Lys Pro Ser Pro Phe Ile Phe Ile Ser Gln Arg Pro Ser Pro Glu 
        275                 280                 285             


Thr Gln Asp Thr Ile His Pro Leu Asp Glu Glu Ala Phe Leu Lys Val 
    290                 295                 300                 


Ser Pro Glu Leu Lys Asn Leu Asp Leu His Gly Ser Thr Asp Ser Gly 
305                 310                 315                 320 


Phe Gly Ser Thr Lys Pro Ser Leu Gln Thr Glu Glu Pro Gln Phe Leu 
                325                 330                 335     


Leu Pro Asp Pro His Pro Gln Ala Asp Arg Thr Leu Gly Asn Arg Glu 
            340                 345                 350         


Pro Pro Val Leu Gly Asp Ser Cys Ser Ser Gly Ser Ser Asn Ser Thr 
        355                 360                 365             


Asp Ser Gly Ile Cys Leu Gln Glu Pro Ser Leu Ser Pro Ser Thr Gly 
    370                 375                 380                 


Pro Thr Trp Glu Gln Gln Val Gly Ser Asn Ser Arg Gly Gln Asp Asp 
385                 390                 395                 400 


Ser Gly Ile Asp Leu Val Gln Asn Ser Glu Gly Arg Ala Gly Asp Thr 
                405                 410                 415     


Gln Gly Gly Ser Ala Leu Gly His His Ser Pro Pro Glu Pro Glu Val 
            420                 425                 430         


Pro Gly Glu Glu Asp Pro Ala Ala Val Ala Phe Gln Gly Tyr Leu Arg 
        435                 440                 445             


Gln Thr Arg Cys Ala Glu Glu Lys Ala Thr Lys Thr Gly Cys Leu Glu 
    450                 455                 460                 


Glu Glu Ser Pro Leu Thr Asp Gly Leu Gly Pro Lys Phe Gly Arg Cys 
465                 470                 475                 480 


Leu Val Asp Glu Ala Gly Leu His Pro Pro Ala Leu Ala Lys Gly Tyr 
                485                 490                 495     


Leu Lys Gln Asp Pro Leu Glu Met Thr Leu Ala Ser Ser Gly Ala Pro 
            500                 505                 510         


Thr Gly Gln Trp Asn Gln Pro Thr Glu Glu Trp Ser Leu Leu Ala Leu 
        515                 520                 525             


Ser Ser Cys Ser Asp Leu Gly Ile Ser Asp Trp Ser Phe Ala His Asp 
    530                 535                 540                 


Leu Ala Pro Leu Gly Cys Val Ala Ala Pro Gly Gly Leu Leu Gly Ser 
545                 550                 555                 560 


Phe Asn Ser Asp Leu Val Thr Leu Pro Leu Ile Ser Ser Leu Gln Ser 
                565                 570                 575     


Ser Glu 
        


<210> 10
<211> 946
<212> PRT
<213> Homo sapiens

<400> 10
Met Lys Arg Leu Thr Cys Phe Phe Ile Cys Phe Phe Leu Ser Glu Val 
1               5                   10                  15      


Ser Gly Phe Glu Ile Pro Ile Asn Gly Leu Ser Glu Phe Val Asp Tyr 
            20                  25                  30          


Glu Asp Leu Val Glu Leu Ala Pro Gly Lys Phe Gln Leu Val Ala Glu 
        35                  40                  45              


Asn Arg Arg Tyr Gln Arg Ser Leu Pro Gly Glu Ser Glu Glu Met Met 
    50                  55                  60                  


Glu Glu Val Asp Gln Val Thr Leu Tyr Ser Tyr Lys Val Gln Ser Thr 
65                  70                  75                  80  


Ile Thr Ser Arg Met Ala Thr Thr Met Ile Gln Ser Lys Val Val Asn 
                85                  90                  95      


Asn Ser Pro Gln Pro Gln Asn Val Val Phe Asp Val Gln Ile Pro Lys 
            100                 105                 110         


Gly Ala Phe Ile Ser Asn Phe Ser Met Thr Val Asp Gly Lys Thr Phe 
        115                 120                 125             


Arg Ser Ser Ile Lys Glu Lys Thr Val Gly Arg Ala Leu Tyr Ala Gln 
    130                 135                 140                 


Ala Arg Ala Lys Gly Lys Thr Ala Gly Leu Val Arg Ser Ser Ala Leu 
145                 150                 155                 160 


Asp Met Glu Asn Phe Arg Thr Glu Val Asn Val Leu Pro Gly Ala Lys 
                165                 170                 175     


Val Gln Phe Glu Leu His Tyr Gln Glu Val Lys Trp Arg Lys Leu Gly 
            180                 185                 190         


Ser Tyr Glu His Arg Ile Tyr Leu Gln Pro Gly Arg Leu Ala Lys His 
        195                 200                 205             


Leu Glu Val Asp Val Trp Val Ile Glu Pro Gln Gly Leu Arg Phe Leu 
    210                 215                 220                 


His Val Pro Asp Thr Phe Glu Gly His Phe Asp Gly Val Pro Val Ile 
225                 230                 235                 240 


Ser Lys Gly Gln Gln Lys Ala His Val Ser Phe Lys Pro Thr Val Ala 
                245                 250                 255     


Gln Gln Arg Ile Cys Pro Asn Cys Arg Glu Thr Ala Val Asp Gly Glu 
            260                 265                 270         


Leu Val Val Leu Tyr Asp Val Lys Arg Glu Glu Lys Ala Gly Glu Leu 
        275                 280                 285             


Glu Val Phe Asn Gly Tyr Phe Val His Phe Phe Ala Pro Asp Asn Leu 
    290                 295                 300                 


Asp Pro Ile Pro Lys Asn Ile Leu Phe Val Ile Asp Val Ser Gly Ser 
305                 310                 315                 320 


Met Trp Gly Val Lys Met Lys Gln Thr Val Glu Ala Met Lys Thr Ile 
                325                 330                 335     


Leu Asp Asp Leu Arg Ala Glu Asp His Phe Ser Val Ile Asp Phe Asn 
            340                 345                 350         


Gln Asn Ile Arg Thr Trp Arg Asn Asp Leu Ile Ser Ala Thr Lys Thr 
        355                 360                 365             


Gln Val Ala Asp Ala Lys Arg Tyr Ile Glu Lys Ile Gln Pro Ser Gly 
    370                 375                 380                 


Gly Thr Asn Ile Asn Glu Ala Leu Leu Arg Ala Ile Phe Ile Leu Asn 
385                 390                 395                 400 


Glu Ala Asn Asn Leu Gly Leu Leu Asp Pro Asn Ser Val Ser Leu Ile 
                405                 410                 415     


Ile Leu Val Ser Asp Gly Asp Pro Thr Val Gly Glu Leu Lys Leu Ser 
            420                 425                 430         


Lys Ile Gln Lys Asn Val Lys Glu Asn Ile Gln Asp Asn Ile Ser Leu 
        435                 440                 445             


Phe Ser Leu Gly Met Gly Phe Asp Val Asp Tyr Asp Phe Leu Lys Arg 
    450                 455                 460                 


Leu Ser Asn Glu Asn His Gly Ile Ala Gln Arg Ile Tyr Gly Asn Gln 
465                 470                 475                 480 


Asp Thr Ser Ser Gln Leu Lys Lys Phe Tyr Asn Gln Val Ser Thr Pro 
                485                 490                 495     


Leu Leu Arg Asn Val Gln Phe Asn Tyr Pro His Thr Ser Val Thr Asp 
            500                 505                 510         


Val Thr Gln Asn Asn Phe His Asn Tyr Phe Gly Gly Ser Glu Ile Val 
        515                 520                 525             


Val Ala Gly Lys Phe Asp Pro Ala Lys Leu Asp Gln Ile Glu Ser Val 
    530                 535                 540                 


Ile Thr Ala Thr Ser Ala Asn Thr Gln Leu Val Leu Glu Thr Leu Ala 
545                 550                 555                 560 


Gln Met Asp Asp Leu Gln Asp Phe Leu Ser Lys Asp Lys His Ala Asp 
                565                 570                 575     


Pro Asp Phe Thr Arg Lys Leu Trp Ala Tyr Leu Thr Ile Asn Gln Leu 
            580                 585                 590         


Leu Ala Glu Arg Ser Leu Ala Pro Thr Ala Ala Ala Lys Arg Arg Ile 
        595                 600                 605             


Thr Arg Ser Ile Leu Gln Met Ser Leu Asp His His Ile Val Thr Pro 
    610                 615                 620                 


Leu Thr Ser Leu Val Ile Glu Asn Glu Ala Gly Asp Glu Arg Met Leu 
625                 630                 635                 640 


Ala Asp Ala Pro Pro Gln Asp Pro Ser Cys Cys Ser Gly Ala Leu Tyr 
                645                 650                 655     


Tyr Gly Ser Lys Val Val Pro Asp Ser Thr Pro Ser Trp Ala Asn Pro 
            660                 665                 670         


Ser Pro Thr Pro Val Ile Ser Met Leu Ala Gln Gly Ser Gln Val Leu 
        675                 680                 685             


Glu Ser Thr Pro Pro Pro His Val Met Arg Val Glu Asn Asp Pro His 
    690                 695                 700                 


Phe Ile Ile Tyr Leu Pro Lys Ser Gln Lys Asn Ile Cys Phe Asn Ile 
705                 710                 715                 720 


Asp Ser Glu Pro Gly Lys Ile Leu Asn Leu Val Ser Asp Pro Glu Ser 
                725                 730                 735     


Gly Ile Val Val Asn Gly Gln Leu Val Gly Ala Lys Lys Pro Asn Asn 
            740                 745                 750         


Gly Lys Leu Ser Thr Tyr Phe Gly Lys Leu Gly Phe Tyr Phe Gln Ser 
        755                 760                 765             


Glu Asp Ile Lys Ile Glu Ile Ser Thr Glu Thr Ile Thr Leu Ser His 
    770                 775                 780                 


Gly Ser Ser Thr Phe Ser Leu Ser Trp Ser Asp Thr Ala Gln Val Thr 
785                 790                 795                 800 


Asn Gln Arg Val Gln Ile Ser Val Lys Lys Glu Lys Val Val Thr Ile 
                805                 810                 815     


Thr Leu Asp Lys Glu Met Ser Phe Ser Val Leu Leu His Arg Val Trp 
            820                 825                 830         


Lys Lys His Pro Val Asn Val Asp Phe Leu Gly Ile Tyr Ile Pro Pro 
        835                 840                 845             


Thr Asn Lys Phe Ser Pro Lys Ala His Gly Leu Ile Gly Gln Phe Met 
    850                 855                 860                 


Gln Glu Pro Lys Ile His Ile Phe Asn Glu Arg Pro Gly Lys Asp Pro 
865                 870                 875                 880 


Glu Lys Pro Glu Ala Ser Met Glu Val Lys Gly Gln Lys Leu Ile Ile 
                885                 890                 895     


Thr Arg Gly Leu Gln Lys Asp Tyr Arg Thr Asp Leu Val Phe Gly Thr 
            900                 905                 910         


Asp Val Thr Cys Trp Phe Val His Asn Ser Gly Lys Gly Phe Ile Asp 
        915                 920                 925             


Gly His Tyr Lys Asp Tyr Phe Val Pro Gln Leu Tyr Ser Phe Leu Lys 
    930                 935                 940                 


Arg Pro 
945     


<210> 11
<211> 427
<212> PRT
<213> Homo sapiens

<400> 11
Met His Leu Ile Asp Tyr Leu Leu Leu Leu Leu Val Gly Leu Leu Ala 
1               5                   10                  15      


Leu Ser His Gly Gln Leu His Val Glu His Asp Gly Glu Ser Cys Ser 
            20                  25                  30          


Asn Ser Ser His Gln Gln Ile Leu Glu Thr Gly Glu Gly Ser Pro Ser 
        35                  40                  45              


Leu Lys Ile Ala Pro Ala Asn Ala Asp Phe Ala Phe Arg Phe Tyr Tyr 
    50                  55                  60                  


Leu Ile Ala Ser Glu Thr Pro Gly Lys Asn Ile Phe Phe Ser Pro Leu 
65                  70                  75                  80  


Ser Ile Ser Ala Ala Tyr Ala Met Leu Ser Leu Gly Ala Cys Ser His 
                85                  90                  95      


Ser Arg Ser Gln Ile Leu Glu Gly Leu Gly Phe Asn Leu Thr Glu Leu 
            100                 105                 110         


Ser Glu Ser Asp Val His Arg Gly Phe Gln His Leu Leu His Thr Leu 
        115                 120                 125             


Asn Leu Pro Gly His Gly Leu Glu Thr Arg Val Gly Ser Ala Leu Phe 
    130                 135                 140                 


Leu Ser His Asn Leu Lys Phe Leu Ala Lys Phe Leu Asn Asp Thr Met 
145                 150                 155                 160 


Ala Val Tyr Glu Ala Lys Leu Phe His Thr Asn Phe Tyr Asp Thr Val 
                165                 170                 175     


Gly Thr Ile Gln Leu Ile Asn Asp His Val Lys Lys Glu Thr Arg Gly 
            180                 185                 190         


Lys Ile Val Asp Leu Val Ser Glu Leu Lys Lys Asp Val Leu Met Val 
        195                 200                 205             


Leu Val Asn Tyr Ile Tyr Phe Lys Ala Leu Trp Glu Lys Pro Phe Ile 
    210                 215                 220                 


Ser Ser Arg Thr Thr Pro Lys Asp Phe Tyr Val Asp Glu Asn Thr Thr 
225                 230                 235                 240 


Val Arg Val Pro Met Met Leu Gln Asp Gln Glu His His Trp Tyr Leu 
                245                 250                 255     


His Asp Arg Tyr Leu Pro Cys Ser Val Leu Arg Met Asp Tyr Lys Gly 
            260                 265                 270         


Asp Ala Thr Val Phe Phe Ile Leu Pro Asn Gln Gly Lys Met Arg Glu 
        275                 280                 285             


Ile Glu Glu Val Leu Thr Pro Glu Met Leu Met Arg Trp Asn Asn Leu 
    290                 295                 300                 


Leu Arg Lys Arg Asn Phe Tyr Lys Lys Leu Glu Leu His Leu Pro Lys 
305                 310                 315                 320 


Phe Ser Ile Ser Gly Ser Tyr Val Leu Asp Gln Ile Leu Pro Arg Leu 
                325                 330                 335     


Gly Phe Thr Asp Leu Phe Ser Lys Trp Ala Asp Leu Ser Gly Ile Thr 
            340                 345                 350         


Lys Gln Gln Lys Leu Glu Ala Ser Lys Ser Phe His Lys Ala Thr Leu 
        355                 360                 365             


Asp Val Asp Glu Ala Gly Thr Glu Ala Ala Ala Ala Thr Ser Phe Ala 
    370                 375                 380                 


Ile Lys Phe Phe Ser Ala Gln Thr Asn Arg His Ile Leu Arg Phe Asn 
385                 390                 395                 400 


Arg Pro Phe Leu Val Val Ile Phe Ser Thr Ser Thr Gln Ser Val Leu 
                405                 410                 415     


Phe Leu Gly Lys Val Val Asp Pro Thr Lys Pro 
            420                 425         


<210> 12
<211> 355
<212> PRT
<213> Homo sapiens

<400> 12
Met Ala Lys Leu Ile Ala Leu Thr Leu Leu Gly Met Gly Leu Ala Leu 
1               5                   10                  15      


Phe Arg Asn His Gln Ser Ser Tyr Gln Thr Arg Leu Asn Ala Leu Arg 
            20                  25                  30          


Glu Val Gln Pro Val Glu Leu Pro Asn Cys Asn Leu Val Lys Gly Ile 
        35                  40                  45              


Glu Thr Gly Ser Glu Asp Leu Glu Ile Leu Pro Asn Gly Leu Ala Phe 
    50                  55                  60                  


Ile Ser Ser Gly Leu Lys Tyr Pro Gly Ile Lys Ser Phe Asn Pro Asn 
65                  70                  75                  80  


Ser Pro Gly Lys Ile Leu Leu Met Asp Leu Asn Glu Glu Asp Pro Thr 
                85                  90                  95      


Val Leu Glu Leu Gly Ile Thr Gly Ser Lys Phe Asp Val Ser Ser Phe 
            100                 105                 110         


Asn Pro His Gly Ile Ser Thr Phe Thr Asp Glu Asp Asn Ala Met Tyr 
        115                 120                 125             


Leu Leu Val Val Asn His Pro Asp Ala Lys Ser Thr Val Glu Leu Phe 
    130                 135                 140                 


Lys Phe Gln Glu Glu Glu Lys Ser Leu Leu His Leu Lys Thr Ile Arg 
145                 150                 155                 160 


His Lys Leu Leu Pro Asn Leu Asn Asp Ile Val Ala Val Gly Pro Glu 
                165                 170                 175     


His Phe Tyr Gly Thr Asn Asp His Tyr Phe Leu Asp Pro Tyr Leu Gln 
            180                 185                 190         


Ser Trp Glu Met Tyr Leu Gly Leu Ala Trp Ser Tyr Val Val Tyr Tyr 
        195                 200                 205             


Ser Pro Ser Glu Val Arg Val Val Ala Glu Gly Phe Asp Phe Ala Asn 
    210                 215                 220                 


Gly Ile Asn Ile Ser Pro Asp Gly Lys Tyr Val Tyr Ile Ala Glu Leu 
225                 230                 235                 240 


Leu Ala His Lys Ile His Val Tyr Glu Lys His Ala Asn Trp Thr Leu 
                245                 250                 255     


Thr Pro Leu Lys Ser Leu Asp Phe Asn Thr Leu Val Asp Asn Ile Ser 
            260                 265                 270         


Val Asp Pro Glu Thr Gly Asp Leu Trp Val Gly Cys His Pro Asn Gly 
        275                 280                 285             


Met Lys Ile Phe Phe Tyr Asp Ser Glu Asn Pro Pro Ala Ser Glu Val 
    290                 295                 300                 


Leu Arg Ile Gln Asn Ile Leu Thr Glu Glu Pro Lys Val Thr Gln Val 
305                 310                 315                 320 


Tyr Ala Glu Asn Gly Thr Val Leu Gln Gly Ser Thr Val Ala Ser Val 
                325                 330                 335     


Tyr Lys Gly Lys Leu Leu Ile Gly Thr Val Phe His Lys Ala Leu Tyr 
            340                 345                 350         


Cys Glu Leu 
        355 


<210> 13
<211> 1337
<212> PRT
<213> Homo sapiens

<400> 13
Met Lys Pro Ala Ala Arg Glu Ala Arg Leu Pro Pro Arg Ser Pro Gly 
1               5                   10                  15      


Leu Arg Trp Ala Leu Pro Leu Leu Leu Leu Leu Leu Arg Leu Gly Gln 
            20                  25                  30          


Ile Leu Cys Ala Gly Gly Thr Pro Ser Pro Ile Pro Asp Pro Ser Val 
        35                  40                  45              


Ala Thr Val Ala Thr Gly Glu Asn Gly Ile Thr Gln Ile Ser Ser Thr 
    50                  55                  60                  


Ala Glu Ser Phe His Lys Gln Asn Gly Thr Gly Thr Pro Gln Val Glu 
65                  70                  75                  80  


Thr Asn Thr Ser Glu Asp Gly Glu Ser Ser Gly Ala Asn Asp Ser Leu 
                85                  90                  95      


Arg Thr Pro Glu Gln Gly Ser Asn Gly Thr Asp Gly Ala Ser Gln Lys 
            100                 105                 110         


Thr Pro Ser Ser Thr Gly Pro Ser Pro Val Phe Asp Ile Lys Ala Val 
        115                 120                 125             


Ser Ile Ser Pro Thr Asn Val Ile Leu Thr Trp Lys Ser Asn Asp Thr 
    130                 135                 140                 


Ala Ala Ser Glu Tyr Lys Tyr Val Val Lys His Lys Met Glu Asn Glu 
145                 150                 155                 160 


Lys Thr Ile Thr Val Val His Gln Pro Trp Cys Asn Ile Thr Gly Leu 
                165                 170                 175     


Arg Pro Ala Thr Ser Tyr Val Phe Ser Ile Thr Pro Gly Ile Gly Asn 
            180                 185                 190         


Glu Thr Trp Gly Asp Pro Arg Val Ile Lys Val Ile Thr Glu Pro Ile 
        195                 200                 205             


Pro Val Ser Asp Leu Arg Val Ala Leu Thr Gly Val Arg Lys Ala Ala 
    210                 215                 220                 


Leu Ser Trp Ser Asn Gly Asn Gly Thr Ala Ser Cys Arg Val Leu Leu 
225                 230                 235                 240 


Glu Ser Ile Gly Ser His Glu Glu Leu Thr Gln Asp Ser Arg Leu Gln 
                245                 250                 255     


Val Asn Ile Ser Gly Leu Lys Pro Gly Val Gln Tyr Asn Ile Asn Pro 
            260                 265                 270         


Tyr Leu Leu Gln Ser Asn Lys Thr Lys Gly Asp Pro Leu Gly Thr Glu 
        275                 280                 285             


Gly Gly Leu Asp Ala Ser Asn Thr Glu Arg Ser Arg Ala Gly Ser Pro 
    290                 295                 300                 


Thr Ala Pro Val His Asp Glu Ser Leu Val Gly Pro Val Asp Pro Ser 
305                 310                 315                 320 


Ser Gly Gln Gln Ser Arg Asp Thr Glu Val Leu Leu Val Gly Leu Glu 
                325                 330                 335     


Pro Gly Thr Arg Tyr Asn Ala Thr Val Tyr Ser Gln Ala Ala Asn Gly 
            340                 345                 350         


Thr Glu Gly Gln Pro Gln Ala Ile Glu Phe Arg Thr Asn Ala Ile Gln 
        355                 360                 365             


Val Phe Asp Val Thr Ala Val Asn Ile Ser Ala Thr Ser Leu Thr Leu 
    370                 375                 380                 


Ile Trp Lys Val Ser Asp Asn Glu Ser Ser Ser Asn Tyr Thr Tyr Lys 
385                 390                 395                 400 


Ile His Val Ala Gly Glu Thr Asp Ser Ser Asn Leu Asn Val Ser Glu 
                405                 410                 415     


Pro Arg Ala Val Ile Pro Gly Leu Arg Ser Ser Thr Phe Tyr Asn Ile 
            420                 425                 430         


Thr Val Cys Pro Val Leu Gly Asp Ile Glu Gly Thr Pro Gly Phe Leu 
        435                 440                 445             


Gln Val His Thr Pro Pro Val Pro Val Ser Asp Phe Arg Val Thr Val 
    450                 455                 460                 


Val Ser Thr Thr Glu Ile Gly Leu Ala Trp Ser Ser His Asp Ala Glu 
465                 470                 475                 480 


Ser Phe Gln Met His Ile Thr Gln Glu Gly Ala Gly Asn Ser Arg Val 
                485                 490                 495     


Glu Ile Thr Thr Asn Gln Ser Ile Ile Ile Gly Gly Leu Phe Pro Gly 
            500                 505                 510         


Thr Lys Tyr Cys Phe Glu Ile Val Pro Lys Gly Pro Asn Gly Thr Glu 
        515                 520                 525             


Gly Ala Ser Arg Thr Val Cys Asn Arg Thr Val Pro Ser Ala Val Phe 
    530                 535                 540                 


Asp Ile His Val Val Tyr Val Thr Thr Thr Glu Met Trp Leu Asp Trp 
545                 550                 555                 560 


Lys Ser Pro Asp Gly Ala Ser Glu Tyr Val Tyr His Leu Val Ile Glu 
                565                 570                 575     


Ser Lys His Gly Ser Asn His Thr Ser Thr Tyr Asp Lys Ala Ile Thr 
            580                 585                 590         


Leu Gln Gly Leu Ile Pro Gly Thr Leu Tyr Asn Ile Thr Ile Ser Pro 
        595                 600                 605             


Glu Val Asp His Val Trp Gly Asp Pro Asn Ser Thr Ala Gln Tyr Thr 
    610                 615                 620                 


Arg Pro Ser Asn Val Ser Asn Ile Asp Val Ser Thr Asn Thr Thr Ala 
625                 630                 635                 640 


Ala Thr Leu Ser Trp Gln Asn Phe Asp Asp Ala Ser Pro Thr Tyr Ser 
                645                 650                 655     


Tyr Cys Leu Leu Ile Glu Lys Ala Gly Asn Ser Ser Asn Ala Thr Gln 
            660                 665                 670         


Val Val Thr Asp Ile Gly Ile Thr Asp Ala Thr Val Thr Glu Leu Ile 
        675                 680                 685             


Pro Gly Ser Ser Tyr Thr Val Glu Ile Phe Ala Gln Val Gly Asp Gly 
    690                 695                 700                 


Ile Lys Ser Leu Glu Pro Gly Arg Lys Ser Phe Cys Thr Asp Pro Ala 
705                 710                 715                 720 


Ser Met Ala Ser Phe Asp Cys Glu Val Val Pro Lys Glu Pro Ala Leu 
                725                 730                 735     


Val Leu Lys Trp Thr Cys Pro Pro Gly Ala Asn Ala Gly Phe Glu Leu 
            740                 745                 750         


Glu Val Ser Ser Gly Ala Trp Asn Asn Ala Thr His Leu Glu Ser Cys 
        755                 760                 765             


Ser Ser Glu Asn Gly Thr Glu Tyr Arg Thr Glu Val Thr Tyr Leu Asn 
    770                 775                 780                 


Phe Ser Thr Ser Tyr Asn Ile Ser Ile Thr Thr Val Ser Cys Gly Lys 
785                 790                 795                 800 


Met Ala Ala Pro Thr Arg Asn Thr Cys Thr Thr Gly Ile Thr Asp Pro 
                805                 810                 815     


Pro Pro Pro Asp Gly Ser Pro Asn Ile Thr Ser Val Ser His Asn Ser 
            820                 825                 830         


Val Lys Val Lys Phe Ser Gly Phe Glu Ala Ser His Gly Pro Ile Lys 
        835                 840                 845             


Ala Tyr Ala Val Ile Leu Thr Thr Gly Glu Ala Gly His Pro Ser Ala 
    850                 855                 860                 


Asp Val Leu Lys Tyr Thr Tyr Glu Asp Phe Lys Lys Gly Ala Ser Asp 
865                 870                 875                 880 


Thr Tyr Val Thr Tyr Leu Ile Arg Thr Glu Glu Lys Gly Arg Ser Gln 
                885                 890                 895     


Ser Leu Ser Glu Val Leu Lys Tyr Glu Ile Asp Val Gly Asn Glu Ser 
            900                 905                 910         


Thr Thr Leu Gly Tyr Tyr Asn Gly Lys Leu Glu Pro Leu Gly Ser Tyr 
        915                 920                 925             


Arg Ala Cys Val Ala Gly Phe Thr Asn Ile Thr Phe His Pro Gln Asn 
    930                 935                 940                 


Lys Gly Leu Ile Asp Gly Ala Glu Ser Tyr Val Ser Phe Ser Arg Tyr 
945                 950                 955                 960 


Ser Asp Ala Val Ser Leu Pro Gln Asp Pro Gly Val Ile Cys Gly Ala 
                965                 970                 975     


Val Phe Gly Cys Ile Phe Gly Ala Leu Val Ile Val Thr Val Gly Gly 
            980                 985                 990         


Phe Ile Phe Trp Arg Lys Lys Arg  Lys Asp Ala Lys Asn  Asn Glu Val 
        995                 1000                 1005             


Ser Phe  Ser Gln Ile Lys Pro  Lys Lys Ser Lys Leu  Ile Arg Val 
    1010                 1015                 1020             


Glu Asn  Phe Glu Ala Tyr Phe  Lys Lys Gln Gln Ala  Asp Ser Asn 
    1025                 1030                 1035             


Cys Gly  Phe Ala Glu Glu Tyr  Glu Asp Leu Lys Leu  Val Gly Ile 
    1040                 1045                 1050             


Ser Gln  Pro Lys Tyr Ala Ala  Glu Leu Ala Glu Asn  Arg Gly Lys 
    1055                 1060                 1065             


Asn Arg  Tyr Asn Asn Val Leu  Pro Tyr Asp Ile Ser  Arg Val Lys 
    1070                 1075                 1080             


Leu Ser  Val Gln Thr His Ser  Thr Asp Asp Tyr Ile  Asn Ala Asn 
    1085                 1090                 1095             


Tyr Met  Pro Gly Tyr His Ser  Lys Lys Asp Phe Ile  Ala Thr Gln 
    1100                 1105                 1110             


Gly Pro  Leu Pro Asn Thr Leu  Lys Asp Phe Trp Arg  Met Val Trp 
    1115                 1120                 1125             


Glu Lys  Asn Val Tyr Ala Ile  Ile Met Leu Thr Lys  Cys Val Glu 
    1130                 1135                 1140             


Gln Gly  Arg Thr Lys Cys Glu  Glu Tyr Trp Pro Ser  Lys Gln Ala 
    1145                 1150                 1155             


Gln Asp  Tyr Gly Asp Ile Thr  Val Ala Met Thr Ser  Glu Ile Val 
    1160                 1165                 1170             


Leu Pro  Glu Trp Thr Ile Arg  Asp Phe Thr Val Lys  Asn Ile Gln 
    1175                 1180                 1185             


Thr Ser  Glu Ser His Pro Leu  Arg Gln Phe His Phe  Thr Ser Trp 
    1190                 1195                 1200             


Pro Asp  His Gly Val Pro Asp  Thr Thr Asp Leu Leu  Ile Asn Phe 
    1205                 1210                 1215             


Arg Tyr  Leu Val Arg Asp Tyr  Met Lys Gln Ser Pro  Pro Glu Ser 
    1220                 1225                 1230             


Pro Ile  Leu Val His Cys Ser  Ala Gly Val Gly Arg  Thr Gly Thr 
    1235                 1240                 1245             


Phe Ile  Ala Ile Asp Arg Leu  Ile Tyr Gln Ile Glu  Asn Glu Asn 
    1250                 1255                 1260             


Thr Val  Asp Val Tyr Gly Ile  Val Tyr Asp Leu Arg  Met His Arg 
    1265                 1270                 1275             


Pro Leu  Met Val Gln Thr Glu  Asp Gln Tyr Val Phe  Leu Asn Gln 
    1280                 1285                 1290             


Cys Val  Leu Asp Ile Val Arg  Ser Gln Lys Asp Ser  Lys Val Asp 
    1295                 1300                 1305             


Leu Ile  Tyr Gln Asn Thr Thr  Ala Met Thr Ile Tyr  Glu Asn Leu 
    1310                 1315                 1320             


Ala Pro  Val Thr Thr Phe Gly  Lys Thr Asn Gly Tyr  Ile Ala 
    1325                 1330                 1335         


<210> 14
<211> 211
<212> PRT
<213> Homo sapiens

<400> 14
Met Ile Ser Arg Met Glu Lys Met Thr Met Met Met Lys Ile Leu Ile 
1               5                   10                  15      


Met Phe Ala Leu Gly Met Asn Tyr Trp Ser Cys Ser Gly Phe Pro Val 
            20                  25                  30          


Tyr Asp Tyr Asp Pro Ser Ser Leu Arg Asp Ala Leu Ser Ala Ser Val 
        35                  40                  45              


Val Lys Val Asn Ser Gln Ser Leu Ser Pro Tyr Leu Phe Arg Ala Phe 
    50                  55                  60                  


Arg Ser Ser Leu Lys Arg Val Glu Val Leu Asp Glu Asn Asn Leu Val 
65                  70                  75                  80  


Met Asn Leu Glu Phe Ser Ile Arg Glu Thr Thr Cys Arg Lys Asp Ser 
                85                  90                  95      


Gly Glu Asp Pro Ala Thr Cys Ala Phe Gln Arg Asp Tyr Tyr Val Ser 
            100                 105                 110         


Thr Ala Val Cys Arg Ser Thr Val Lys Val Ser Ala Gln Gln Val Gln 
        115                 120                 125             


Gly Val His Ala Arg Cys Ser Trp Ser Ser Ser Thr Ser Glu Ser Tyr 
    130                 135                 140                 


Ser Ser Glu Glu Met Ile Phe Gly Asp Met Leu Gly Ser His Lys Trp 
145                 150                 155                 160 


Arg Asn Asn Tyr Leu Phe Gly Leu Ile Ser Asp Glu Ser Ile Ser Glu 
                165                 170                 175     


Gln Phe Tyr Asp Arg Ser Leu Gly Ile Met Arg Arg Val Leu Pro Pro 
            180                 185                 190         


Gly Asn Arg Arg Tyr Pro Asn His Arg His Arg Ala Arg Ile Asn Thr 
        195                 200                 205             


Asp Phe Glu 
    210     


<210> 15
<211> 760
<212> PRT
<213> Homo sapiens

<400> 15
Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Gly Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210> 16
<211> 251
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Glu Asp Leu Gly Leu Ser Phe Gly Glu Thr Ala Ser Val Glu 
1               5                   10                  15      


Met Leu Pro Glu His Gly Ser Cys Arg Pro Lys Ala Arg Ser Ser Ser 
            20                  25                  30          


Ala Arg Trp Ala Leu Thr Cys Cys Leu Val Leu Leu Pro Phe Leu Ala 
        35                  40                  45              


Gly Leu Thr Thr Tyr Leu Leu Val Ser Gln Leu Arg Ala Gln Gly Glu 
    50                  55                  60                  


Ala Cys Val Gln Phe Gln Ala Leu Lys Gly Gln Glu Phe Ala Pro Ser 
65                  70                  75                  80  


His Gln Gln Val Tyr Ala Pro Leu Arg Ala Asp Gly Asp Lys Pro Arg 
                85                  90                  95      


Ala His Leu Thr Val Val Arg Gln Thr Pro Thr Gln His Phe Lys Asn 
            100                 105                 110         


Gln Phe Pro Ala Leu His Trp Glu His Glu Leu Gly Leu Ala Phe Thr 
        115                 120                 125             


Lys Asn Arg Met Asn Tyr Thr Asn Lys Phe Leu Leu Ile Pro Glu Ser 
    130                 135                 140                 


Gly Asp Tyr Phe Ile Tyr Ser Gln Val Thr Phe Arg Gly Met Thr Ser 
145                 150                 155                 160 


Glu Cys Ser Glu Ile Arg Gln Ala Gly Arg Pro Asn Lys Pro Asp Ser 
                165                 170                 175     


Ile Thr Val Val Ile Thr Lys Val Thr Asp Ser Tyr Pro Glu Pro Thr 
            180                 185                 190         


Gln Leu Leu Met Gly Thr Lys Ser Val Cys Glu Val Gly Ser Asn Trp 
        195                 200                 205             


Phe Gln Pro Ile Tyr Leu Gly Ala Met Phe Ser Leu Gln Glu Gly Asp 
    210                 215                 220                 


Lys Leu Met Val Asn Val Ser Asp Ile Ser Leu Val Asp Tyr Thr Lys 
225                 230                 235                 240 


Glu Asp Lys Thr Phe Phe Gly Ala Phe Leu Leu 
                245                 250     


<210> 17
<211> 291
<212> PRT
<213> Homo sapiens

<400> 17
Met Gln Arg Ala Arg Pro Thr Leu Trp Ala Ala Ala Leu Thr Leu Leu 
1               5                   10                  15      


Val Leu Leu Arg Gly Pro Pro Val Ala Arg Ala Gly Ala Ser Ser Ala 
            20                  25                  30          


Gly Leu Gly Pro Val Val Arg Cys Glu Pro Cys Asp Ala Arg Ala Leu 
        35                  40                  45              


Ala Gln Cys Ala Pro Pro Pro Ala Val Cys Ala Glu Leu Val Arg Glu 
    50                  55                  60                  


Pro Gly Cys Gly Cys Cys Leu Thr Cys Ala Leu Ser Glu Gly Gln Pro 
65                  70                  75                  80  


Cys Gly Ile Tyr Thr Glu Arg Cys Gly Ser Gly Leu Arg Cys Gln Pro 
                85                  90                  95      


Ser Pro Asp Glu Ala Arg Pro Leu Gln Ala Leu Leu Asp Gly Arg Gly 
            100                 105                 110         


Leu Cys Val Asn Ala Ser Ala Val Ser Arg Leu Arg Ala Tyr Leu Leu 
        115                 120                 125             


Pro Ala Pro Pro Ala Pro Gly Asn Ala Ser Glu Ser Glu Glu Asp Arg 
    130                 135                 140                 


Ser Ala Gly Ser Val Glu Ser Pro Ser Val Ser Ser Thr His Arg Val 
145                 150                 155                 160 


Ser Asp Pro Lys Phe His Pro Leu His Ser Lys Ile Ile Ile Ile Lys 
                165                 170                 175     


Lys Gly His Ala Lys Asp Ser Gln Arg Tyr Lys Val Asp Tyr Glu Ser 
            180                 185                 190         


Gln Ser Thr Asp Thr Gln Asn Phe Ser Ser Glu Ser Lys Arg Glu Thr 
        195                 200                 205             


Glu Tyr Gly Pro Cys Arg Arg Glu Met Glu Asp Thr Leu Asn His Leu 
    210                 215                 220                 


Lys Phe Leu Asn Val Leu Ser Pro Arg Gly Val His Ile Pro Asn Cys 
225                 230                 235                 240 


Asp Lys Lys Gly Phe Tyr Lys Lys Lys Gln Cys Arg Pro Ser Lys Gly 
                245                 250                 255     


Arg Lys Arg Gly Phe Cys Trp Cys Val Asp Lys Tyr Gly Gln Pro Leu 
            260                 265                 270         


Pro Gly Tyr Thr Thr Lys Gly Lys Glu Asp Val His Cys Tyr Ser Met 
        275                 280                 285             


Gln Ser Lys 
    290     


<210> 18
<211> 461
<212> PRT
<213> Homo sapiens

<400> 18
Met Thr Pro Asn Ser Met Thr Glu Asn Gly Leu Thr Ala Trp Asp Lys 
1               5                   10                  15      


Pro Lys His Cys Pro Asp Arg Glu His Asp Trp Lys Leu Val Gly Met 
            20                  25                  30          


Ser Glu Ala Cys Leu His Arg Lys Ser His Ser Glu Arg Arg Ser Thr 
        35                  40                  45              


Leu Lys Asn Glu Gln Ser Ser Pro His Leu Ile Gln Thr Thr Trp Thr 
    50                  55                  60                  


Ser Ser Ile Phe His Leu Asp His Asp Asp Val Asn Asp Gln Ser Val 
65                  70                  75                  80  


Ser Ser Ala Gln Thr Phe Gln Thr Glu Glu Lys Lys Cys Lys Gly Tyr 
                85                  90                  95      


Ile Pro Ser Tyr Leu Asp Lys Asp Glu Leu Cys Val Val Cys Gly Asp 
            100                 105                 110         


Lys Ala Thr Gly Tyr His Tyr Arg Cys Ile Thr Cys Glu Gly Cys Lys 
        115                 120                 125             


Gly Phe Phe Arg Arg Thr Ile Gln Lys Asn Leu His Pro Ser Tyr Ser 
    130                 135                 140                 


Cys Lys Tyr Glu Gly Lys Cys Val Ile Asp Lys Val Thr Arg Asn Gln 
145                 150                 155                 160 


Cys Gln Glu Cys Arg Phe Lys Lys Cys Ile Tyr Val Gly Met Ala Thr 
                165                 170                 175     


Asp Leu Val Leu Asp Asp Ser Lys Arg Leu Ala Lys Arg Lys Leu Ile 
            180                 185                 190         


Glu Glu Asn Arg Glu Lys Arg Arg Arg Glu Glu Leu Gln Lys Ser Ile 
        195                 200                 205             


Gly His Lys Pro Glu Pro Thr Asp Glu Glu Trp Glu Leu Ile Lys Thr 
    210                 215                 220                 


Val Thr Glu Ala His Val Ala Thr Asn Ala Gln Gly Ser His Trp Lys 
225                 230                 235                 240 


Gln Lys Arg Lys Phe Leu Pro Glu Asp Ile Gly Gln Ala Pro Ile Val 
                245                 250                 255     


Asn Ala Pro Glu Gly Gly Lys Val Asp Leu Glu Ala Phe Ser His Phe 
            260                 265                 270         


Thr Lys Ile Ile Thr Pro Ala Ile Thr Arg Val Val Asp Phe Ala Lys 
        275                 280                 285             


Lys Leu Pro Met Phe Cys Glu Leu Pro Cys Glu Asp Gln Ile Ile Leu 
    290                 295                 300                 


Leu Lys Gly Cys Cys Met Glu Ile Met Ser Leu Arg Ala Ala Val Arg 
305                 310                 315                 320 


Tyr Asp Pro Glu Ser Glu Thr Leu Thr Leu Asn Gly Glu Met Ala Val 
                325                 330                 335     


Thr Arg Gly Gln Leu Lys Asn Gly Gly Leu Gly Val Val Ser Asp Ala 
            340                 345                 350         


Ile Phe Asp Leu Gly Met Ser Leu Ser Ser Phe Asn Leu Asp Asp Thr 
        355                 360                 365             


Glu Val Ala Leu Leu Gln Ala Val Leu Leu Met Ser Ser Asp Arg Pro 
    370                 375                 380                 


Gly Leu Ala Cys Val Glu Arg Ile Glu Lys Tyr Gln Asp Ser Phe Leu 
385                 390                 395                 400 


Leu Ala Phe Glu His Tyr Ile Asn Tyr Arg Lys His His Val Thr His 
                405                 410                 415     


Phe Trp Pro Lys Leu Leu Met Lys Val Thr Asp Leu Arg Met Ile Gly 
            420                 425                 430         


Ala Cys His Ala Ser Arg Phe Leu His Met Lys Val Glu Cys Pro Thr 
        435                 440                 445             


Glu Leu Phe Pro Pro Leu Phe Leu Glu Val Phe Glu Asp 
    450                 455                 460     


<210> 19
<211> 115
<212> PRT
<213> Homo sapiens

<400> 19
Met Asn Ala Phe Leu Leu Ser Ala Leu Cys Leu Leu Gly Ala Trp Ala 
1               5                   10                  15      


Ala Leu Ala Gly Gly Val Thr Val Gln Asp Gly Asn Phe Ser Phe Ser 
            20                  25                  30          


Leu Glu Ser Val Lys Lys Leu Lys Asp Leu Gln Glu Pro Gln Glu Pro 
        35                  40                  45              


Arg Val Gly Lys Leu Arg Asn Phe Ala Pro Ile Pro Gly Glu Pro Val 
    50                  55                  60                  


Val Pro Ile Leu Cys Ser Asn Pro Asn Phe Pro Glu Glu Leu Lys Pro 
65                  70                  75                  80  


Leu Cys Lys Glu Pro Asn Ala Gln Glu Ile Leu Gln Arg Leu Glu Glu 
                85                  90                  95      


Ile Ala Glu Asp Pro Gly Thr Cys Glu Ile Cys Ala Tyr Ala Ala Cys 
            100                 105                 110         


Thr Gly Cys 
        115 


<210> 20
<211> 131
<212> PRT
<213> Homo sapiens

<400> 20
Met Thr Pro Leu Leu Thr Leu Ile Leu Val Val Leu Met Gly Leu Pro 
1               5                   10                  15      


Leu Ala Gln Ala Leu Asp Cys His Val Cys Ala Tyr Asn Gly Asp Asn 
            20                  25                  30          


Cys Phe Asn Pro Met Arg Cys Pro Ala Met Val Ala Tyr Cys Met Thr 
        35                  40                  45              


Thr Arg Thr Ser Ala Ala Glu Ala Ile Trp Cys His Gln Cys Thr Gly 
    50                  55                  60                  


Phe Gly Gly Cys Ser His Gly Ser Arg Cys Leu Arg Asp Ser Thr His 
65                  70                  75                  80  


Cys Val Thr Thr Ala Thr Arg Val Leu Ser Asn Thr Glu Asp Leu Pro 
                85                  90                  95      


Leu Val Thr Lys Met Cys His Ile Gly Cys Pro Asp Ile Pro Ser Leu 
            100                 105                 110         


Gly Leu Gly Pro Tyr Val Ser Ile Ala Cys Cys Gln Thr Ser Leu Cys 
        115                 120                 125             


Asn His Asp 
    130     


<210> 21
<211> 1606
<212> PRT
<213> Homo sapiens

<400> 21
Met Ser Glu Asp Ser Arg Gly Asp Ser Arg Ala Glu Ser Ala Lys Asp 
1               5                   10                  15      


Leu Glu Lys Gln Leu Arg Leu Arg Val Cys Val Leu Ser Glu Leu Gln 
            20                  25                  30          


Lys Thr Glu Arg Asp Tyr Val Gly Thr Leu Glu Phe Leu Val Ser Ala 
        35                  40                  45              


Phe Leu His Arg Met Asn Gln Cys Ala Ala Ser Lys Val Asp Lys Asn 
    50                  55                  60                  


Val Thr Glu Glu Thr Val Lys Met Leu Phe Ser Asn Ile Glu Asp Ile 
65                  70                  75                  80  


Leu Ala Val His Lys Glu Phe Leu Lys Val Val Glu Glu Cys Leu His 
                85                  90                  95      


Pro Glu Pro Asn Ala Gln Gln Glu Val Gly Thr Cys Phe Leu His Phe 
            100                 105                 110         


Lys Asp Lys Phe Arg Ile Tyr Asp Glu Tyr Cys Ser Asn His Glu Lys 
        115                 120                 125             


Ala Gln Lys Leu Leu Leu Glu Leu Asn Lys Ile Arg Thr Ile Arg Thr 
    130                 135                 140                 


Phe Leu Leu Asn Cys Met Leu Leu Gly Gly Arg Lys Asn Thr Asp Val 
145                 150                 155                 160 


Pro Leu Glu Gly Tyr Leu Val Thr Pro Ile Gln Arg Ile Cys Lys Tyr 
                165                 170                 175     


Pro Leu Ile Leu Lys Glu Leu Leu Lys Arg Thr Pro Arg Lys His Ser 
            180                 185                 190         


Asp Tyr Ala Ala Val Met Glu Ala Leu Gln Ala Met Lys Ala Val Cys 
        195                 200                 205             


Ser Asn Ile Asn Glu Ala Lys Arg Gln Met Glu Lys Leu Glu Val Leu 
    210                 215                 220                 


Glu Glu Trp Gln Ser His Ile Glu Gly Trp Glu Gly Ser Asn Ile Thr 
225                 230                 235                 240 


Asp Thr Cys Thr Glu Met Leu Met Cys Gly Val Leu Leu Lys Ile Ser 
                245                 250                 255     


Ser Gly Asn Ile Gln Glu Arg Val Phe Phe Leu Phe Asp Asn Leu Leu 
            260                 265                 270         


Val Tyr Cys Lys Arg Lys His Arg Arg Leu Lys Asn Ser Lys Ala Ser 
        275                 280                 285             


Thr Asp Gly His Arg Tyr Leu Phe Arg Gly Arg Ile Asn Thr Glu Val 
    290                 295                 300                 


Met Glu Val Glu Asn Val Asp Asp Gly Thr Ala Asp Phe His Ser Ser 
305                 310                 315                 320 


Gly His Ile Val Val Asn Gly Trp Lys Ile His Asn Thr Ala Lys Asn 
                325                 330                 335     


Lys Trp Phe Val Cys Met Ala Lys Thr Pro Glu Glu Lys His Glu Trp 
            340                 345                 350         


Phe Glu Ala Ile Leu Lys Glu Arg Glu Arg Arg Lys Gly Leu Lys Leu 
        355                 360                 365             


Gly Met Glu Gln Asp Thr Trp Val Met Ile Ser Glu Gln Gly Glu Lys 
    370                 375                 380                 


Leu Tyr Lys Met Met Cys Arg Gln Gly Asn Leu Ile Lys Asp Arg Lys 
385                 390                 395                 400 


Arg Lys Leu Thr Thr Phe Pro Lys Cys Phe Leu Gly Ser Glu Phe Val 
                405                 410                 415     


Ser Trp Leu Leu Glu Ile Gly Glu Ile His Arg Pro Glu Glu Gly Val 
            420                 425                 430         


His Leu Gly Gln Ala Leu Leu Glu Asn Gly Ile Ile His His Val Thr 
        435                 440                 445             


Asp Lys His Gln Phe Lys Pro Glu Gln Met Leu Tyr Arg Phe Arg Tyr 
    450                 455                 460                 


Asp Asp Gly Thr Phe Tyr Pro Arg Asn Glu Met Gln Asp Val Ile Ser 
465                 470                 475                 480 


Lys Gly Val Arg Leu Tyr Cys Arg Leu His Ser Leu Phe Thr Pro Val 
                485                 490                 495     


Ile Arg Asp Lys Asp Tyr His Leu Arg Thr Tyr Lys Ser Val Val Met 
            500                 505                 510         


Ala Asn Lys Leu Ile Asp Trp Leu Ile Ala Gln Gly Asp Cys Arg Thr 
        515                 520                 525             


Arg Glu Glu Ala Met Ile Phe Gly Val Gly Leu Cys Asp Asn Gly Phe 
    530                 535                 540                 


Met His His Val Leu Glu Lys Ser Glu Phe Lys Asp Glu Pro Leu Leu 
545                 550                 555                 560 


Phe Arg Phe Phe Ser Asp Glu Glu Met Glu Gly Ser Asn Met Lys His 
                565                 570                 575     


Arg Leu Met Lys His Asp Leu Lys Val Val Glu Asn Val Ile Ala Lys 
            580                 585                 590         


Ser Leu Leu Ile Lys Ser Asn Glu Gly Ser Tyr Gly Phe Gly Leu Glu 
        595                 600                 605             


Asp Lys Asn Lys Val Pro Ile Ile Lys Leu Val Glu Lys Gly Ser Asn 
    610                 615                 620                 


Ala Glu Met Ala Gly Met Glu Val Gly Lys Lys Ile Phe Ala Ile Asn 
625                 630                 635                 640 


Gly Asp Leu Val Phe Met Arg Pro Phe Asn Glu Val Asp Cys Phe Leu 
                645                 650                 655     


Lys Ser Cys Leu Asn Ser Arg Lys Pro Leu Arg Val Leu Val Ser Thr 
            660                 665                 670         


Lys Pro Arg Glu Thr Val Lys Ile Pro Asp Ser Ala Asp Gly Leu Gly 
        675                 680                 685             


Phe Gln Ile Arg Gly Phe Gly Pro Ser Val Val His Ala Val Gly Arg 
    690                 695                 700                 


Gly Thr Val Ala Ala Ala Ala Gly Leu His Pro Gly Gln Cys Ile Ile 
705                 710                 715                 720 


Lys Val Asn Gly Ile Asn Val Ser Lys Glu Thr His Ala Ser Val Ile 
                725                 730                 735     


Ala His Val Thr Ala Cys Arg Lys Tyr Arg Arg Pro Thr Lys Gln Asp 
            740                 745                 750         


Ser Ile Gln Trp Val Tyr Asn Ser Ile Glu Ser Ala Gln Glu Asp Leu 
        755                 760                 765             


Gln Lys Ser His Ser Lys Pro Pro Gly Asp Glu Ala Gly Asp Ala Phe 
    770                 775                 780                 


Asp Cys Lys Val Glu Glu Val Ile Asp Lys Phe Asn Thr Met Ala Ile 
785                 790                 795                 800 


Ile Asp Gly Lys Lys Glu His Val Ser Leu Thr Val Asp Asn Val His 
                805                 810                 815     


Leu Glu Tyr Gly Val Val Tyr Glu Tyr Asp Ser Thr Ala Gly Ile Lys 
            820                 825                 830         


Cys Asn Val Val Glu Lys Met Ile Glu Pro Lys Gly Phe Phe Ser Leu 
        835                 840                 845             


Thr Ala Lys Ile Leu Glu Ala Leu Ala Lys Ser Asp Glu His Phe Val 
    850                 855                 860                 


Gln Asn Cys Thr Ser Leu Asn Ser Leu Asn Glu Val Ile Pro Thr Asp 
865                 870                 875                 880 


Leu Gln Ser Lys Phe Ser Ala Leu Cys Ser Glu Arg Ile Glu His Leu 
                885                 890                 895     


Cys Gln Arg Ile Ser Ser Tyr Lys Lys Phe Ser Arg Val Leu Lys Asn 
            900                 905                 910         


Arg Ala Trp Pro Thr Phe Lys Gln Ala Lys Ser Lys Ile Ser Pro Leu 
        915                 920                 925             


His Ser Ser Asp Phe Cys Pro Thr Asn Cys His Val Asn Val Met Glu 
    930                 935                 940                 


Val Ser Tyr Pro Lys Thr Ser Thr Ser Leu Gly Ser Ala Phe Gly Val 
945                 950                 955                 960 


Gln Leu Asp Ser Arg Lys His Asn Ser His Asp Lys Glu Asn Lys Ser 
                965                 970                 975     


Ser Glu Gln Gly Lys Leu Ser Pro Met Val Tyr Ile Gln His Thr Ile 
            980                 985                 990         


Thr Thr Met Ala Ala Pro Ser Gly  Leu Ser Leu Gly Gln  Gln Asp Gly 
        995                 1000                 1005             


His Gly  Leu Arg Tyr Leu Leu  Lys Glu Glu Asp Leu  Glu Thr Gln 
    1010                 1015                 1020             


Asp Ile  Tyr Gln Lys Leu Leu  Gly Lys Leu Gln Thr  Ala Leu Lys 
    1025                 1030                 1035             


Glu Val  Glu Met Cys Val Cys  Gln Ile Asp Asp Leu  Leu Ser Ser 
    1040                 1045                 1050             


Ile Thr  Tyr Ser Pro Lys Leu  Glu Arg Lys Thr Ser  Glu Gly Ile 
    1055                 1060                 1065             


Ile Pro  Thr Asp Ser Asp Asn  Glu Lys Gly Glu Arg  Asn Ser Lys 
    1070                 1075                 1080             


Arg Val  Cys Phe Asn Val Ala  Gly Asp Glu Gln Glu  Asp Ser Gly 
    1085                 1090                 1095             


His Asp  Thr Ile Ser Asn Arg  Asp Ser Tyr Ser Asp  Cys Asn Ser 
    1100                 1105                 1110             


Asn Arg  Asn Ser Ile Ala Ser  Phe Thr Ser Ile Cys  Ser Ser Gln 
    1115                 1120                 1125             


Cys Ser  Ser Tyr Phe His Ser  Asp Glu Met Asp Ser  Gly Asp Glu 
    1130                 1135                 1140             


Leu Pro  Leu Ser Val Arg Ile  Ser His Asp Lys Gln  Asp Lys Ile 
    1145                 1150                 1155             


His Ser  Cys Leu Glu His Leu  Phe Ser Gln Val Asp  Ser Ile Thr 
    1160                 1165                 1170             


Asn Leu  Leu Lys Gly Gln Ala  Val Val Arg Ala Phe  Asp Gln Thr 
    1175                 1180                 1185             


Lys Tyr  Leu Thr Pro Gly Arg  Gly Leu Gln Glu Phe  Gln Gln Glu 
    1190                 1195                 1200             


Met Glu  Pro Lys Leu Ser Cys  Pro Lys Arg Leu Arg  Leu His Ile 
    1205                 1210                 1215             


Lys Gln  Asp Pro Trp Asn Leu  Pro Ser Ser Val Arg  Thr Leu Ala 
    1220                 1225                 1230             


Gln Asn  Ile Arg Lys Phe Val  Glu Glu Val Lys Cys  Arg Leu Leu 
    1235                 1240                 1245             


Leu Ala  Leu Leu Glu Tyr Ser  Asp Ser Glu Thr Gln  Leu Arg Arg 
    1250                 1255                 1260             


Asp Met  Val Phe Cys Gln Thr  Leu Val Ala Thr Val  Cys Ala Phe 
    1265                 1270                 1275             


Ser Glu  Gln Leu Met Ala Ala  Leu Asn Gln Met Phe  Asp Asn Ser 
    1280                 1285                 1290             


Lys Glu  Asn Glu Met Glu Thr  Trp Glu Ala Ser Arg  Arg Trp Leu 
    1295                 1300                 1305             


Asp Gln  Ile Ala Asn Ala Gly  Val Leu Phe His Phe  Gln Ser Leu 
    1310                 1315                 1320             


Leu Ser  Pro Asn Leu Thr Asp  Glu Gln Ala Met Leu  Glu Asp Thr 
    1325                 1330                 1335             


Leu Val  Ala Leu Phe Asp Leu  Glu Lys Val Ser Phe  Tyr Phe Lys 
    1340                 1345                 1350             


Pro Ser  Glu Glu Glu Pro Leu  Val Ala Asn Val Pro  Leu Thr Tyr 
    1355                 1360                 1365             


Gln Ala  Glu Gly Ser Arg Gln  Ala Leu Lys Val Tyr  Phe Tyr Ile 
    1370                 1375                 1380             


Asp Ser  Tyr His Phe Glu Gln  Leu Pro Gln Arg Leu  Lys Asn Gly 
    1385                 1390                 1395             


Gly Gly  Phe Lys Ile His Pro  Val Leu Phe Ala Gln  Ala Leu Glu 
    1400                 1405                 1410             


Ser Met  Glu Gly Tyr Tyr Tyr  Arg Asp Asn Val Ser  Val Glu Glu 
    1415                 1420                 1425             


Phe Gln  Ala Gln Ile Asn Ala  Ala Ser Leu Glu Lys  Val Lys Gln 
    1430                 1435                 1440             


Tyr Asn  Gln Lys Leu Arg Ala  Phe Tyr Leu Asp Lys  Ser Asn Ser 
    1445                 1450                 1455             


Pro Pro  Asn Ser Thr Ser Lys  Ala Ala Tyr Val Asp  Lys Leu Met 
    1460                 1465                 1470             


Arg Pro  Leu Asn Ala Leu Asp  Glu Leu Tyr Arg Leu  Val Ala Ser 
    1475                 1480                 1485             


Phe Ile  Arg Ser Lys Arg Thr  Ala Ala Cys Ala Asn  Thr Ala Cys 
    1490                 1495                 1500             


Ser Ala  Ser Gly Val Gly Leu  Leu Ser Val Ser Ser  Glu Leu Cys 
    1505                 1510                 1515             


Asn Arg  Leu Gly Ala Cys His  Ile Ile Met Cys Ser  Ser Gly Val 
    1520                 1525                 1530             


His Arg  Cys Thr Leu Ser Val  Thr Leu Glu Gln Ala  Ile Ile Leu 
    1535                 1540                 1545             


Ala Arg  Ser His Gly Leu Pro  Pro Arg Tyr Ile Met  Gln Ala Thr 
    1550                 1555                 1560             


Asp Val  Met Arg Lys Gln Gly  Ala Arg Val Gln Asn  Thr Ala Lys 
    1565                 1570                 1575             


Asn Leu  Gly Val Arg Asp Arg  Thr Pro Gln Ser Ala  Pro Arg Leu 
    1580                 1585                 1590             


Tyr Lys  Leu Cys Glu Pro Pro  Pro Pro Ala Gly Glu  Glu 
    1595                 1600                 1605     


<210> 22
<211> 201
<212> PRT
<213> Homo sapiens

<400> 22
Met Lys Trp Val Trp Ala Leu Leu Leu Leu Ala Ala Leu Gly Ser Gly 
1               5                   10                  15      


Arg Ala Glu Arg Asp Cys Arg Val Ser Ser Phe Arg Val Lys Glu Asn 
            20                  25                  30          


Phe Asp Lys Ala Arg Phe Ser Gly Thr Trp Tyr Ala Met Ala Lys Lys 
        35                  40                  45              


Asp Pro Glu Gly Leu Phe Leu Gln Asp Asn Ile Val Ala Glu Phe Ser 
    50                  55                  60                  


Val Asp Glu Thr Gly Gln Met Ser Ala Thr Ala Lys Gly Arg Val Arg 
65                  70                  75                  80  


Leu Leu Asn Asn Trp Asp Val Cys Ala Asp Met Val Gly Thr Phe Thr 
                85                  90                  95      


Asp Thr Glu Asp Pro Ala Lys Phe Lys Met Lys Tyr Trp Gly Val Ala 
            100                 105                 110         


Ser Phe Leu Gln Lys Gly Asn Asp Asp His Trp Ile Val Asp Thr Asp 
        115                 120                 125             


Tyr Asp Thr Tyr Ala Val Gln Tyr Ser Cys Arg Leu Leu Asn Leu Asp 
    130                 135                 140                 


Gly Thr Cys Ala Asp Ser Tyr Ser Phe Val Phe Ser Arg Asp Pro Asn 
145                 150                 155                 160 


Gly Leu Pro Pro Glu Ala Gln Lys Ile Val Arg Gln Arg Gln Glu Glu 
                165                 170                 175     


Leu Cys Leu Ala Arg Gln Tyr Arg Leu Ile Val His Asn Gly Tyr Cys 
            180                 185                 190         


Asp Gly Arg Ser Glu Arg Asn Leu Leu 
        195                 200     


<210> 23
<211> 14
<212> PRT
<213> Homo sapiens

<400> 23
Ala Gly Asp Phe Leu Glu Ala Asn Tyr Met Asn Leu Gln Arg 
1               5                   10                  


<210> 24
<211> 6
<212> PRT
<213> Homo sapiens

<400> 24
Ser Leu Tyr Leu Gly Arg 
1               5       


<210> 25
<211> 10
<212> PRT
<213> Homo sapiens

<400> 25
Asp Leu Leu Leu Pro Gln Pro Asp Leu Arg 
1               5                   10  


<210> 26
<211> 10
<212> PRT
<213> Homo sapiens

<400> 26
Val Ala Ala Gly Ala Phe Gln Gly Leu Arg 
1               5                   10  


<210> 27
<211> 10
<212> PRT
<213> Homo sapiens

<400> 27
Val Ala Ala Gly Ala Phe Gln Gly Leu Arg 
1               5                   10  


<210> 28
<211> 6
<212> PRT
<213> Homo sapiens

<400> 28
Glu Leu Asp Leu Ser Arg 
1               5       


<210> 29
<211> 7
<212> PRT
<213> Homo sapiens

<400> 29
Leu Phe Gln Gly Leu Gly Lys 
1               5           


<210> 30
<211> 7
<212> PRT
<213> Homo sapiens

<400> 30
Leu Phe Gln Gly Leu Gly Lys 
1               5           


<210> 31
<211> 8
<212> PRT
<213> Homo sapiens

<400> 31
Phe Leu Asn Val Leu Ser Pro Arg 
1               5               


<210> 32
<211> 11
<212> PRT
<213> Homo sapiens

<400> 32
Tyr Gly Gln Pro Leu Pro Gly Tyr Thr Thr Lys 
1               5                   10      


<210> 33
<211> 7
<212> PRT
<213> Homo sapiens

<400> 33
Val Ala Leu Thr Gly Val Arg 
1               5           


<210> 34
<211> 6
<212> PRT
<213> Homo sapiens

<400> 34
Ile Tyr Ile His Pro Arg 
1               5       


<210> 35
<211> 16
<212> PRT
<213> Homo sapiens

<400> 35
Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
1               5                   10                  15      


<210> 36
<211> 7
<212> PRT
<213> Homo sapiens

<400> 36
Ala Trp Phe Leu Glu Ser Lys 
1               5           


<210> 37
<211> 7
<212> PRT
<213> Homo sapiens

<400> 37
Ala Gln Ala Trp Gly Glu Arg 
1               5           


<210> 38
<211> 7
<212> PRT
<213> Homo sapiens

<400> 38
Ala Leu Asp Asn Leu Ala Arg 
1               5           


<210> 39
<211> 10
<212> PRT
<213> Homo sapiens

<400> 39
Glu Pro Asn Ala Gln Glu Ile Leu Gln Arg 
1               5                   10  


<210> 40
<211> 7
<212> PRT
<213> Homo sapiens

<400> 40
Glu Tyr Glu Ile Ala Ile Arg 
1               5           


<210> 41
<211> 6
<212> PRT
<213> Homo sapiens

<400> 41
Thr Ala Gly Leu Val Arg 
1               5       


<210> 42
<211> 7
<212> PRT
<213> Homo sapiens

<400> 42
Leu Glu Leu His Leu Pro Lys 
1               5           


<210> 43
<211> 13
<212> PRT
<213> Homo sapiens

<400> 43
Val Leu Ser Asn Thr Glu Asp Leu Pro Leu Val Thr Lys 
1               5                   10              


<210> 44
<211> 6
<212> PRT
<213> Homo sapiens

<400> 44
Ser Leu Leu His Leu Lys 
1               5       


<210> 45
<211> 6
<212> PRT
<213> Homo sapiens

<400> 45
Ser Leu Leu His Leu Lys 
1               5       


<210> 46
<211> 6
<212> PRT
<213> Homo sapiens

<400> 46
Ala Phe Tyr Leu Asp Lys 
1               5       


<210> 47
<211> 10
<212> PRT
<213> Homo sapiens

<400> 47
Tyr Trp Gly Val Ala Ser Phe Leu Gln Lys 
1               5                   10  


<210> 48
<211> 9
<212> PRT
<213> Homo sapiens

<400> 48
Asp Ala Leu Ser Ala Ser Val Val Lys 
1               5                   


<210> 49
<211> 7
<212> PRT
<213> Homo sapiens

<400> 49
Leu Tyr Trp Asp Asp Leu Lys 
1               5           


<210> 50
<211> 10
<212> PRT
<213> Homo sapiens

<400> 50
Ser Gly Val Gly Thr Ala Leu Leu Leu Lys 
1               5                   10  


<210> 51
<211> 10
<212> PRT
<213> Homo sapiens

<400> 51
Ser Gly Val Gly Thr Ala Leu Leu Leu Lys 
1               5                   10  


<210> 52
<211> 7
<212> PRT
<213> Homo sapiens

<400> 52
Ala His Leu Thr Val Val Arg 
1               5           


<210> 53
<211> 7
<212> PRT
<213> Homo sapiens

<400> 53
Glu Phe Gln Glu Gly Leu Lys 
1               5           


<210> 54
<211> 13
<212> PRT
<213> Homo sapiens

<400> 54
Ala Gly Ala Leu Asn Ser Asn Asp Ala Phe Val Leu Lys 
1               5                   10              


<210> 55
<211> 11
<212> PRT
<213> Homo sapiens

<400> 55
His Tyr Gly Tyr Ser Leu Tyr Ser Ala Ile Lys 
1               5                   10      


<210> 56
<211> 9
<212> PRT
<213> Homo sapiens

<400> 56
Thr Leu Thr Leu Leu Ser Val Thr Arg 
1               5                   


<210> 57
<211> 9
<212> PRT
<213> Homo sapiens

<400> 57
Leu Leu Leu Gln Pro Ser Pro Gln Arg 
1               5                   


<210> 58
<211> 15
<212> PRT
<213> Homo sapiens

<400> 58
Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys 
1               5                   10                  15  


<210> 59
<211> 10
<212> PRT
<213> Homo sapiens

<400> 59
Ile Pro Val Gly Pro Glu Thr Leu Gly Arg 
1               5                   10  


<210> 60
<211> 6
<212> PRT
<213> Homo sapiens

<400> 60
Ala Leu Gln Val Val Arg 
1               5       


<210> 61
<211> 7
<212> PRT
<213> Homo sapiens

<400> 61
Ser Phe Ala Ile Asn Phe Lys 
1               5           


<210> 62
<211> 12
<212> PRT
<213> Homo sapiens

<400> 62
Ser Phe Glu Asn Ser Leu Gly Ile Asn Val Pro Arg 
1               5                   10          


<210> 63
<211> 14
<212> PRT
<213> Homo sapiens

<400> 63
Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro Lys 
1               5                   10                  


<210> 64
<211> 10
<212> PRT
<213> Homo sapiens

<400> 64
His Thr Leu Asn Gln Ile Asp Glu Val Lys 
1               5                   10  


<210> 65
<211> 9
<212> PRT
<213> Homo sapiens

<400> 65
Ile Ser Ser Pro Thr Glu Thr Glu Arg 
1               5                   


<210> 66
<211> 9
<212> PRT
<213> Homo sapiens

<400> 66
Glu Val Glu Leu Ile Val Gln Glu Lys 
1               5                   


<210> 67
<211> 11
<212> PRT
<213> Homo sapiens

<400> 67
Thr Ala Ala Ser Ile Tyr Glu Glu Leu Leu Lys 
1               5                   10      


<210> 68
<211> 13
<212> PRT
<213> Homo sapiens

<400> 68
Ala Gly Ala Leu Asn Ser Asn Asp Ala Phe Val Leu Lys 
1               5                   10              


<210> 69
<211> 9
<212> PRT
<213> Homo sapiens

<400> 69
His Ser Leu Val Ser Phe Val Val Arg 
1               5                   


<210> 70
<211> 9
<212> PRT
<213> Homo sapiens

<400> 70
Pro Phe Asp Ala Phe Thr Asp Leu Lys 
1               5                   


<210> 71
<211> 8
<212> PRT
<213> Homo sapiens

<400> 71
Gly Lys Ile Thr Asp Leu Ile Lys 
1               5               


