                         SEQUENCE LISTING

<110>  AERase, Inc.
 
<120>  METHOD AND COMPOSITION FOR TREATING ARGINASE 1 DEFICIENCY

<130>  218107-0011-00-WO-582023

<150>  US 62/745,000
<151>  2018-10-12

<150>  US 62/725,612
<151>  2018-08-31

<150>  US 62/594,747
<151>  2017-12-05

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Leu Arg Gly Ser Leu Ser Arg Leu Leu Gln Thr Arg Val His 
1               5                   10                  15      


Ser Ile Leu Lys Lys Ser Val His Ser Val Ala Val Ile Gly Ala Pro 
            20                  25                  30          


Phe Ser Gln Gly Gln Lys Arg Lys Gly Val Glu His Gly Pro Ala Ala 
        35                  40                  45              


Ile Arg Glu Ala Gly Leu Met Lys Arg Leu Ser Ser Leu Gly Cys His 
    50                  55                  60                  


Leu Lys Asp Phe Gly Asp Leu Ser Phe Thr Pro Val Pro Lys Asp Asp 
65                  70                  75                  80  


Leu Tyr Asn Asn Leu Ile Val Asn Pro Arg Ser Val Gly Leu Ala Asn 
                85                  90                  95      


Gln Glu Leu Ala Glu Val Val Ser Arg Ala Val Ser Asp Gly Tyr Ser 
            100                 105                 110         


Cys Val Thr Leu Gly Gly Asp His Ser Leu Ala Ile Gly Thr Ile Ser 
        115                 120                 125             


Gly His Ala Arg His Cys Pro Asp Leu Cys Val Val Trp Val Asp Ala 
    130                 135                 140                 


His Ala Asp Ile Asn Thr Pro Leu Thr Thr Ser Ser Gly Asn Leu His 
145                 150                 155                 160 


Gly Gln Pro Val Ser Phe Leu Leu Arg Glu Leu Gln Asp Lys Val Pro 
                165                 170                 175     


Gln Leu Pro Gly Phe Ser Trp Ile Lys Pro Cys Ile Ser Ser Ala Ser 
            180                 185                 190         


Ile Val Tyr Ile Gly Leu Arg Asp Val Asp Pro Pro Glu His Phe Ile 
        195                 200                 205             


Leu Lys Asn Tyr Asp Ile Gln Tyr Phe Ser Met Arg Asp Ile Asp Arg 
    210                 215                 220                 


Leu Gly Ile Gln Lys Val Met Glu Arg Thr Phe Asp Leu Leu Ile Gly 
225                 230                 235                 240 


Lys Arg Gln Arg Pro Ile His Leu Ser Phe Asp Ile Asp Ala Phe Asp 
                245                 250                 255     


Pro Thr Leu Ala Pro Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr 
            260                 265                 270         


Tyr Arg Glu Gly Met Tyr Ile Ala Glu Glu Ile His Asn Thr Gly Leu 
        275                 280                 285             


Leu Ser Ala Leu Asp Leu Val Glu Val Asn Pro Gln Leu Ala Thr Ser 
    290                 295                 300                 


Glu Glu Glu Ala Lys Thr Thr Ala Asn Leu Ala Val Asp Val Ile Ala 
305                 310                 315                 320 


Ser Ser Phe Gly Gln Thr Arg Glu Gly Gly His Ile Val Tyr Asp Gln 
                325                 330                 335     


Leu Pro Thr Pro Ser Ser Pro Asp Glu Ser Glu Asn Gln Ala Arg Val 
            340                 345                 350         


Arg Ile 
        


<210>  2
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser 
1               5                   10                  15      


Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg 
            20                  25                  30          


Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys 
        35                  40                  45              


Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe 
    50                  55                  60                  


Gln Ile Val Lys Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu 
65                  70                  75                  80  


Ala Gly Lys Val Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val 
                85                  90                  95      


Leu Gly Gly Asp His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala 
            100                 105                 110         


Arg Val His Pro Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp 
        115                 120                 125             


Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro 
    130                 135                 140                 


Val Ser Phe Leu Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro 
145                 150                 155                 160 


Gly Phe Ser Trp Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr 
                165                 170                 175     


Ile Gly Leu Arg Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr 
            180                 185                 190         


Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile 
        195                 200                 205             


Gly Lys Val Met Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys 
    210                 215                 220                 


Arg Pro Ile His Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe 
225                 230                 235                 240 


Thr Pro Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu 
                245                 250                 255     


Gly Leu Tyr Ile Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly 
            260                 265                 270         


Leu Asp Ile Met Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu 
        275                 280                 285             


Val Thr Arg Thr Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe 
    290                 295                 300                 


Gly Leu Ala Arg Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro 
305                 310                 315                 320 


Pro Lys 
        


