                         SEQUENCE LISTING

<110>  Universitaet zu Koeln
 
<120>  COMBINATIONS OF RIPK1- AND IKK-INHIBITORS FOR THE PREVENTION OR 
       TREATMENT OF IMMUNE DISEASES

<130>  U30819WO

<150>  EP17205864.6
<151>  2017-12-07

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Pro Asp Met Ser Leu Asn Val Ile Lys Met Lys Ser Ser Asp 
1               5                   10                  15      


Phe Leu Glu Ser Ala Glu Leu Asp Ser Gly Gly Phe Gly Lys Val Ser 
            20                  25                  30          


Leu Cys Phe His Arg Thr Gln Gly Leu Met Ile Met Lys Thr Val Tyr 
        35                  40                  45              


Lys Gly Pro Asn Cys Ile Glu His Asn Glu Ala Leu Leu Glu Glu Ala 
    50                  55                  60                  


Lys Met Met Asn Arg Leu Arg His Ser Arg Val Val Lys Leu Leu Gly 
65                  70                  75                  80  


Val Ile Ile Glu Glu Gly Lys Tyr Ser Leu Val Met Glu Tyr Met Glu 
                85                  90                  95      


Lys Gly Asn Leu Met His Val Leu Lys Ala Glu Met Ser Thr Pro Leu 
            100                 105                 110         


Ser Val Lys Gly Arg Ile Ile Leu Glu Ile Ile Glu Gly Met Cys Tyr 
        115                 120                 125             


Leu His Gly Lys Gly Val Ile His Lys Asp Leu Lys Pro Glu Asn Ile 
    130                 135                 140                 


Leu Val Asp Asn Asp Phe His Ile Lys Ile Ala Asp Leu Gly Leu Ala 
145                 150                 155                 160 


Ser Phe Lys Met Trp Ser Lys Leu Asn Asn Glu Glu His Asn Glu Leu 
                165                 170                 175     


Arg Glu Val Asp Gly Thr Ala Lys Lys Asn Gly Gly Thr Leu Tyr Tyr 
            180                 185                 190         


Met Ala Pro Glu His Leu Asn Asp Val Asn Ala Lys Pro Thr Glu Lys 
        195                 200                 205             


Ser Asp Val Tyr Ser Phe Ala Val Val Leu Trp Ala Ile Phe Ala Asn 
    210                 215                 220                 


Lys Glu Pro Tyr Glu Asn Ala Ile Cys Glu Gln Gln Leu Ile Met Cys 
225                 230                 235                 240 


Ile Lys Ser Gly Asn Arg Pro Asp Val Asp Asp Ile Thr Glu Tyr Cys 
                245                 250                 255     


Pro Arg Glu Ile Ile Ser Leu Met Lys Leu Cys Trp Glu Ala Asn Pro 
            260                 265                 270         


Glu Ala Arg Pro Thr Phe Pro Gly Ile Glu Glu Lys Phe Arg Pro Phe 
        275                 280                 285             


Tyr Leu Ser Gln Leu Glu Glu Ser Val Glu Glu Asp Val Lys Ser Leu 
    290                 295                 300                 


Lys Lys Glu Tyr Ser Asn Glu Asn Ala Val Val Lys Arg Met Gln Ser 
305                 310                 315                 320 


Leu Gln Leu Asp Cys Val Ala Val Pro Ser Ser Arg Ser Asn Ser Ala 
                325                 330                 335     


Thr Glu Gln Pro Gly Ser Leu His Ser Ser Gln Gly Leu Gly Met Gly 
            340                 345                 350         


Pro Val Glu Glu Ser Trp Phe Ala Pro Ser Leu Glu His Pro Gln Glu 
        355                 360                 365             


Glu Asn Glu Pro Ser Leu Gln Ser Lys Leu Gln Asp Glu Ala Asn Tyr 
    370                 375                 380                 


His Leu Tyr Gly Ser Arg Met Asp Arg Gln Thr Lys Gln Gln Pro Arg 
385                 390                 395                 400 


Gln Asn Val Ala Tyr Asn Arg Glu Glu Glu Arg Arg Arg Arg Val Ser 
                405                 410                 415     


His Asp Pro Phe Ala Gln Gln Arg Pro Tyr Glu Asn Phe Gln Asn Thr 
            420                 425                 430         


Glu Gly Lys Gly Thr Ala Tyr Ser Ser Ala Ala Ser His Gly Asn Ala 
        435                 440                 445             


Val His Gln Pro Ser Gly Leu Thr Ser Gln Pro Gln Val Leu Tyr Gln 
    450                 455                 460                 


Asn Asn Gly Leu Tyr Ser Ser His Gly Phe Gly Thr Arg Pro Leu Asp 
465                 470                 475                 480 


Pro Gly Thr Ala Gly Pro Arg Val Trp Tyr Arg Pro Ile Pro Ser His 
                485                 490                 495     


Met Pro Ser Leu His Asn Ile Pro Val Pro Glu Thr Asn Tyr Leu Gly 
            500                 505                 510         


Asn Thr Pro Thr Met Pro Phe Ser Ser Leu Pro Pro Thr Asp Glu Ser 
        515                 520                 525             


Ile Lys Tyr Thr Ile Tyr Asn Ser Thr Gly Ile Gln Ile Gly Ala Tyr 
    530                 535                 540                 


Asn Tyr Met Glu Ile Gly Gly Thr Ser Ser Ser Leu Leu Asp Ser Thr 
545                 550                 555                 560 


Asn Thr Asn Phe Lys Glu Glu Pro Ala Ala Lys Tyr Gln Ala Ile Phe 
                565                 570                 575     


Asp Asn Thr Thr Ser Leu Thr Asp Lys His Leu Asp Pro Ile Arg Glu 
            580                 585                 590         


Asn Leu Gly Lys His Trp Lys Asn Cys Ala Arg Lys Leu Gly Phe Thr 
        595                 600                 605             


Gln Ser Gln Ile Asp Glu Ile Asp His Asp Tyr Glu Arg Asp Gly Leu 
    610                 615                 620                 


Lys Glu Lys Val Tyr Gln Met Leu Gln Lys Trp Val Met Arg Glu Gly 
625                 630                 635                 640 


Ile Lys Gly Ala Thr Val Gly Lys Leu Ala Gln Ala Leu His Gln Cys 
                645                 650                 655     


Ser Arg Ile Asp Leu Leu Ser Ser Leu Ile Tyr Val Ser Gln Asn 
            660                 665                 670     


<210>  2
<211>  756
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Trp Ser Pro Ser Leu Thr Thr Gln Thr Cys Gly Ala Trp Glu 
1               5                   10                  15      


Met Lys Glu Arg Leu Gly Thr Gly Gly Phe Gly Asn Val Ile Arg Trp 
            20                  25                  30          


His Asn Gln Glu Thr Gly Glu Gln Ile Ala Ile Lys Gln Cys Arg Gln 
        35                  40                  45              


Glu Leu Ser Pro Arg Asn Arg Glu Arg Trp Cys Leu Glu Ile Gln Ile 
    50                  55                  60                  


Met Arg Arg Leu Thr His Pro Asn Val Val Ala Ala Arg Asp Val Pro 
65                  70                  75                  80  


Glu Gly Met Gln Asn Leu Ala Pro Asn Asp Leu Pro Leu Leu Ala Met 
                85                  90                  95      


Glu Tyr Cys Gln Gly Gly Asp Leu Arg Lys Tyr Leu Asn Gln Phe Glu 
            100                 105                 110         


Asn Cys Cys Gly Leu Arg Glu Gly Ala Ile Leu Thr Leu Leu Ser Asp 
        115                 120                 125             


Ile Ala Ser Ala Leu Arg Tyr Leu His Glu Asn Arg Ile Ile His Arg 
    130                 135                 140                 


Asp Leu Lys Pro Glu Asn Ile Val Leu Gln Gln Gly Glu Gln Arg Leu 
145                 150                 155                 160 


Ile His Lys Ile Ile Asp Leu Gly Tyr Ala Lys Glu Leu Asp Gln Gly 
                165                 170                 175     


Ser Leu Cys Thr Ser Phe Val Gly Thr Leu Gln Tyr Leu Ala Pro Glu 
            180                 185                 190         


Leu Leu Glu Gln Gln Lys Tyr Thr Val Thr Val Asp Tyr Trp Ser Phe 
        195                 200                 205             


Gly Thr Leu Ala Phe Glu Cys Ile Thr Gly Phe Arg Pro Phe Leu Pro 
    210                 215                 220                 


Asn Trp Gln Pro Val Gln Trp His Ser Lys Val Arg Gln Lys Ser Glu 
225                 230                 235                 240 


Val Asp Ile Val Val Ser Glu Asp Leu Asn Gly Thr Val Lys Phe Ser 
                245                 250                 255     


Ser Ser Leu Pro Tyr Pro Asn Asn Leu Asn Ser Val Leu Ala Glu Arg 
            260                 265                 270         


Leu Glu Lys Trp Leu Gln Leu Met Leu Met Trp His Pro Arg Gln Arg 
        275                 280                 285             


Gly Thr Asp Pro Thr Tyr Gly Pro Asn Gly Cys Phe Lys Ala Leu Asp 
    290                 295                 300                 


Asp Ile Leu Asn Leu Lys Leu Val His Ile Leu Asn Met Val Thr Gly 
305                 310                 315                 320 


Thr Ile His Thr Tyr Pro Val Thr Glu Asp Glu Ser Leu Gln Ser Leu 
                325                 330                 335     


Lys Ala Arg Ile Gln Gln Asp Thr Gly Ile Pro Glu Glu Asp Gln Glu 
            340                 345                 350         


Leu Leu Gln Glu Ala Gly Leu Ala Leu Ile Pro Asp Lys Pro Ala Thr 
        355                 360                 365             


Gln Cys Ile Ser Asp Gly Lys Leu Asn Glu Gly His Thr Leu Asp Met 
    370                 375                 380                 


Asp Leu Val Phe Leu Phe Asp Asn Ser Lys Ile Thr Tyr Glu Thr Gln 
385                 390                 395                 400 


Ile Ser Pro Arg Pro Gln Pro Glu Ser Val Ser Cys Ile Leu Gln Glu 
                405                 410                 415     


Pro Lys Arg Asn Leu Ala Phe Phe Gln Leu Arg Lys Val Trp Gly Gln 
            420                 425                 430         


Val Trp His Ser Ile Gln Thr Leu Lys Glu Asp Cys Asn Arg Leu Gln 
        435                 440                 445             


Gln Gly Gln Arg Ala Ala Met Met Asn Leu Leu Arg Asn Asn Ser Cys 
    450                 455                 460                 


Leu Ser Lys Met Lys Asn Ser Met Ala Ser Met Ser Gln Gln Leu Lys 
465                 470                 475                 480 


Ala Lys Leu Asp Phe Phe Lys Thr Ser Ile Gln Ile Asp Leu Glu Lys 
                485                 490                 495     


Tyr Ser Glu Gln Thr Glu Phe Gly Ile Thr Ser Asp Lys Leu Leu Leu 
            500                 505                 510         


Ala Trp Arg Glu Met Glu Gln Ala Val Glu Leu Cys Gly Arg Glu Asn 
        515                 520                 525             


Glu Val Lys Leu Leu Val Glu Arg Met Met Ala Leu Gln Thr Asp Ile 
    530                 535                 540                 


Val Asp Leu Gln Arg Ser Pro Met Gly Arg Lys Gln Gly Gly Thr Leu 
545                 550                 555                 560 


Asp Asp Leu Glu Glu Gln Ala Arg Glu Leu Tyr Arg Arg Leu Arg Glu 
                565                 570                 575     


Lys Pro Arg Asp Gln Arg Thr Glu Gly Asp Ser Gln Glu Met Val Arg 
            580                 585                 590         


Leu Leu Leu Gln Ala Ile Gln Ser Phe Glu Lys Lys Val Arg Val Ile 
        595                 600                 605             


Tyr Thr Gln Leu Ser Lys Thr Val Val Cys Lys Gln Lys Ala Leu Glu 
    610                 615                 620                 


Leu Leu Pro Lys Val Glu Glu Val Val Ser Leu Met Asn Glu Asp Glu 
625                 630                 635                 640 


Lys Thr Val Val Arg Leu Gln Glu Lys Arg Gln Lys Glu Leu Trp Asn 
                645                 650                 655     


Leu Leu Lys Ile Ala Cys Ser Lys Val Arg Gly Pro Val Ser Gly Ser 
            660                 665                 670         


Pro Asp Ser Met Asn Ala Ser Arg Leu Ser Gln Pro Gly Gln Leu Met 
        675                 680                 685             


Ser Gln Pro Ser Thr Ala Ser Asn Ser Leu Pro Glu Pro Ala Lys Lys 
    690                 695                 700                 


Ser Glu Glu Leu Val Ala Glu Ala His Asn Leu Cys Thr Leu Leu Glu 
705                 710                 715                 720 


Asn Ala Ile Gln Asp Thr Val Arg Glu Gln Asp Gln Ser Phe Thr Ala 
                725                 730                 735     


Leu Asp Trp Ser Trp Leu Gln Thr Glu Glu Glu Glu His Ser Cys Leu 
            740                 745                 750         


Glu Gln Ala Ser 
        755     


<210>  3
<211>  82
<212>  DNA
<213>  Homo sapiens

<400>  3
gcgacaggtg aacagatcgc catcaagcaa tgccgacagg agctcagccc aaagaacaga       60

gaccgctggt gcctcgaaat cc                                                82


<210>  4
<211>  83
<212>  DNA
<213>  Homo sapiens

<400>  4
gcgacaggtg aacagatcgc catcgcgcaa tgccgacagg agctcagccc aaagaacaga       60

gaccgctggt gcctcgaaat cca                                               83


<210>  5
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Thr Gly Glu Gln Ile Ala Ile Lys Gln Cys Arg Gln Glu Leu Ser 
1               5                   10                  15      


Pro Lys Asn Arg Asp Arg Trp Cys Leu Glu Ile Gln 
            20                  25              


<210>  6
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  6
catcaagcaa t                                                            11


<210>  7
<211>  11
<212>  DNA
<213>  Homo sapiens

<400>  7
catcgcgcaa t                                                            11


