SEQUENCE LISTING

<110>   Volution Immuno Pharmaceuticals SA

<120>   Methods for treatment of neuropathic pain

<130>   P071712WO

<141>   2018-12-07

<160>   11

<170>   SeqWin2010, version 1.0

<210>   1
<211>   793
<212>   DNA
<213>   Artificial Sequence

<400>   1
gccgcgacgg aacttcgaag gaagtcagca tgaagcttct catactctct cttgccctcg  60
tcctcgccct cagccaggtt aagggaaatc agccagattg ggccgatgaa gcggcaaatg  120
gtgcacacca agacgcctgg aagagtctga aagcggacgt tgaaaacgtt tactacatgg  180
tgaaggccac ctataagaat gacccagtgt ggggcaatga cttcacttgc gtgggtgtta  240
tggcaaatga tgtcaacgag gatgagaaga gcattcaagc agagtttttg tttatgaata  300
atgctgacac aaacatgcaa ttcgccactg aaaaggtgac tgctgttaaa atgtatggtt  360
acaataggga aaacgccttc agatacgaga cggaggatgg ccaagttttc acagacgtca  420
ttgcatactc tgatgacaac tgcgatgtca tctacgttcc tggcacagac ggaaatgagg  480
aaggttacga actatggact acggattacg acaacattcc agccaattgt ttaaataagt  540
ttaatgagta cgctgtaggt agggagacaa gggatgtatt cacaagtgct tgcctagagt  600
aataacttca gaatgtcgtt ctttcaaagc gaaaaaccaa caatgtgaac atcggcttgc  660
tgtgctcgac gtagccagcg ataatgttgt tttcctgggt ttctgggttt ggatactttt  720
agccactgcc gaagagctgt aaaggtaatg aaaaataaaa tgttcaagag tgtgaaaaaa  780
aaaaaaaaaa aaa                                                     793

<210>   2
<211>   190
<212>   PRT
<213>   Rhipicephalus appendiculatus

<400>   2
Met Lys Leu Leu Ile Leu Ser Leu Ala Leu Val Leu Ala Leu Ser Gln 
1               5                   10                  15      

Val Lys Gly Asn Gln Pro Asp Trp Ala Asp Glu Ala Ala Asn Gly Ala 
            20                  25                  30          

His Gln Asp Ala Trp Lys Ser Leu Lys Ala Asp Val Glu Asn Val Tyr 
        35                  40                  45              

Tyr Met Val Lys Ala Thr Tyr Lys Asn Asp Pro Val Trp Gly Asn Asp 
    50                  55                  60                  

Phe Thr Cys Val Gly Val Met Ala Asn Asp Val Asn Glu Asp Glu Lys 
65                  70                  75                  80  

Ser Ile Gln Ala Glu Phe Leu Phe Met Asn Asn Ala Asp Thr Asn Met 
                85                  90                  95      

Gln Phe Ala Thr Glu Lys Val Thr Ala Val Lys Met Tyr Gly Tyr Asn 
            100                 105                 110         

Arg Glu Asn Ala Phe Arg Tyr Glu Thr Glu Asp Gly Gln Val Phe Thr 
        115                 120                 125             

Asp Val Ile Ala Tyr Ser Asp Asp Asn Cys Asp Val Ile Tyr Val Pro 
    130                 135                 140                 

Gly Thr Asp Gly Asn Glu Glu Gly Tyr Glu Leu Trp Thr Thr Asp Tyr 
145                 150                 155                 160 

Asp Asn Ile Pro Ala Asn Cys Leu Asn Lys Phe Asn Glu Tyr Ala Val 
                165                 170                 175     

Gly Arg Glu Thr Arg Asp Val Phe Thr Ser Ala Cys Leu Glu 
            180                 185                 190 

<210>   3
<211>   770
<212>   DNA
<213>   Artificial Sequence

<400>   3
agaaagccaa catgaagctt ctgctctctc ttgccttcgt cttagctctc agccaagtta  60
aagccgataa gccagtttgg gcggatgaag cggcaaacgg ggaacaccaa gacgcctgga  120
agcatctcca aaaactcgtt gaagagaatt acgacttgat aaaagccacc tacaagaacg  180
acccagtttg gggtaacgac ttcacttgcg tgggtactgc agcgcagaat ttgaacgagg  240
acgagaagaa cgttgaagca tggtttatgt ttatgaataa tgctgatacc gtataccaac  300
atacttttga aaaggcgact cctgataaaa tgtacggtta caataaggaa aacgccatca  360
catatcaaac agaggatggg caagttctca cagacgtcct tgcattctct gacgacaatt  420
gctatgtcat ctacgctctt ggcccagatg gaagtggagc aggttacgaa ctctgggcta  480
ccgattacac ggatgttcca gccagttgtc tagagaagtt caatgagtat gctgcaggtc  540
tgccggtacg ggacgtatac acaagtgatt gcctcccaga ataacttggg catatcgtaa  600
tttcaacttc aaagtgtgtt attgtcagca tatgtctcga gtgtttgatg tagtgcgttc  660
gatgatgcca ttcatctagg tttcgggtgt tcggtacttt atggtcactg ccgacggcca  720
gcacgagtac tcgaaaataa agtattctga aatcggaaaa aaaaaaaaaa             770

<210>   4
<211>   190
<212>   PRT
<213>   Rhipicephalus appendiculatus

<400>   4
Met Lys Leu Leu Leu Ser Leu Ala Phe Val Leu Ala Leu Ser Gln Val 
1               5                   10                  15      

Lys Ala Asp Lys Pro Val Trp Ala Asp Glu Ala Ala Asn Gly Glu His 
            20                  25                  30          

Gln Asp Ala Trp Lys His Leu Gln Lys Leu Val Glu Glu Asn Tyr Asp 
        35                  40                  45              

Leu Ile Lys Ala Thr Tyr Lys Asn Asp Pro Val Trp Gly Asn Asp Phe 
    50                  55                  60                  

Thr Cys Val Gly Thr Ala Ala Gln Asn Leu Asn Glu Asp Glu Lys Asn 
65                  70                  75                  80  

Val Glu Ala Trp Phe Met Phe Met Asn Asn Ala Asp Thr Val Tyr Gln 
                85                  90                  95      

His Thr Phe Glu Lys Ala Thr Pro Asp Lys Met Tyr Gly Tyr Asn Lys 
            100                 105                 110         

Glu Asn Ala Ile Thr Tyr Gln Thr Glu Asp Gly Gln Val Leu Thr Asp 
        115                 120                 125             

Val Leu Ala Phe Ser Asp Asp Asn Cys Tyr Val Ile Tyr Ala Leu Gly 
    130                 135                 140                 

Pro Asp Gly Ser Gly Ala Gly Tyr Glu Leu Trp Ala Thr Asp Tyr Thr 
145                 150                 155                 160 

Asp Val Pro Ala Ser Cys Leu Glu Lys Phe Asn Glu Tyr Ala Ala Gly 
                165                 170                 175     

Leu Pro Val Arg Asp Val Tyr Thr Ser Asp Cys Leu Pro Glu 
            180                 185                 190 

<210>   5
<211>   753
<212>   DNA
<213>   Artificial Sequence

<400>   5
aaagcactca acatgaaggt tcttttgttg gttcttggag ctgctctttg ccagaatgca  60
gatgcaaacc caacatgggc gaacgaagct aaattgggat cctaccaaga cgcctggaag  120
agccttcagc aagaccaaaa caagagatac tatttggcac aagcgacaca aacgactgac  180
ggcgtatggg gtgaagagtt tacttgtgtg agtgttacgg ctgagaagat tggaaagaaa  240
aaacttaacg ctacgatcct ctataaaaat aagcacctta ctgacctgaa agagagtcat  300
gaaacaatca ctgtctggaa agcatacgac tacacaacgg agaatggcat caagtacgag  360
acgcaaggga caaggacgca gactttcgaa gatgtctttg tattctctga ttacaagaac  420
tgcgatgtaa ttttcgttcc caaagagaga ggaagcgacg agggcgacta tgaattgtgg  480
gttagtgaag acaagattga caagattccc gattgctgca agtttacgat ggcgtacttt  540
gcccaacagc aggagaagac ggttcgtaat gtatacactg actcatcatg caaaccagca  600
ccagctcaga actgatattc tggtaatgct tgaaccgtaa tggttcgacc tgcagtctag  660
aaacatttac caccatcacg gtgattatct taccgtagtt tcttaggtct tgttctttga  720
ataaaatagt tccctgcatt gacaaaaaaa aaa                               753

<210>   6
<211>   200
<212>   PRT
<213>   Rhipicephalus appendiculatus

<400>   6
Met Lys Val Leu Leu Leu Val Leu Gly Ala Ala Leu Cys Gln Asn Ala 
1               5                   10                  15      

Asp Ala Asn Pro Thr Trp Ala Asn Glu Ala Lys Leu Gly Ser Tyr Gln 
            20                  25                  30          

Asp Ala Trp Lys Ser Leu Gln Gln Asp Gln Asn Lys Arg Tyr Tyr Leu 
        35                  40                  45              

Ala Gln Ala Thr Gln Thr Thr Asp Gly Val Trp Gly Glu Glu Phe Thr 
    50                  55                  60                  

Cys Val Ser Val Thr Ala Glu Lys Ile Gly Lys Lys Lys Leu Asn Ala 
65                  70                  75                  80  

Thr Ile Leu Tyr Lys Asn Lys His Leu Thr Asp Leu Lys Glu Ser His 
                85                  90                  95      

Glu Thr Ile Thr Val Trp Lys Ala Tyr Asp Tyr Thr Thr Glu Asn Gly 
            100                 105                 110         

Ile Lys Tyr Glu Thr Gln Gly Thr Arg Thr Gln Thr Phe Glu Asp Val 
        115                 120                 125             

Phe Val Phe Ser Asp Tyr Lys Asn Cys Asp Val Ile Phe Val Pro Lys 
    130                 135                 140                 

Glu Arg Gly Ser Asp Glu Gly Asp Tyr Glu Leu Trp Val Ser Glu Asp 
145                 150                 155                 160 

Lys Ile Asp Lys Ile Pro Asp Cys Cys Lys Phe Thr Met Ala Tyr Phe 
                165                 170                 175     

Ala Gln Gln Gln Glu Lys Thr Val Arg Asn Val Tyr Thr Asp Ser Ser 
            180                 185                 190         

Cys Lys Pro Ala Pro Ala Gln Asn 
        195                 200 

<210>   7
<211>   719
<212>   DNA
<213>   Artificial Sequence

<400>   7
atgaagatgc aggtagtgct cttacttacc tttgttagcg ccgccctcgc cactcaagcg  60
gagactacat ctgcgaaagc aggagaaaac ccgctctggg cgcatgagga actacttgga  120
aaatatcaag atgcctggaa aagcatcgat cagggcgtgt cggtgactta tgtccttgca  180
aagacaacat atgagaatga cacaggatca tggggatccc agtttaagtg cctccaggta  240
caagaaatag aaagaaagga agaagactat acagttacat ctgttttcac ctttagaaat  300
gcgtcttctc caatcaagta ttacaacgtg acagaaacag tgaaggccgt ttttcaatat  360
ggatacaaaa acataaggaa tgcaattgaa taccaagtgg gcggtggact taacataacc  420
gacacgctca ttttcactga tggagaatta tgcgatgttt tctatgttcc caatgcagat  480
caaggttgtg agctctgggt caaaaagagt cactacaaac acgtaccaga ctactgcacg  540
ttcgtgttca atgttttctg tgcgaaagac aggaaaacct acgatatatt taatgaagaa  600
tgtgtttata acggcgaacc ctggctttaa aggacccccc tctataaaat acggtttctg  660
tagtaagtac taatagcaag tagttgaata ataaaaagat tgtaagtgca aaaaaaaaa   719

<210>   8
<211>   209
<212>   PRT
<213>   Dermacentor reticulatus

<400>   8
Met Lys Met Gln Val Val Leu Leu Leu Thr Phe Val Ser Ala Ala Leu 
1               5                   10                  15      

Ala Thr Gln Ala Glu Thr Thr Ser Ala Lys Ala Gly Glu Asn Pro Leu 
            20                  25                  30          

Trp Ala His Glu Glu Leu Leu Gly Lys Tyr Gln Asp Ala Trp Lys Ser 
        35                  40                  45              

Ile Asp Gln Gly Val Ser Val Thr Tyr Val Leu Ala Lys Thr Thr Tyr 
    50                  55                  60                  

Glu Asn Asp Thr Gly Ser Trp Gly Ser Gln Phe Lys Cys Leu Gln Val 
65                  70                  75                  80  

Gln Glu Ile Glu Arg Lys Glu Glu Asp Tyr Thr Val Thr Ser Val Phe 
                85                  90                  95      

Thr Phe Arg Asn Ala Ser Ser Pro Ile Lys Tyr Tyr Asn Val Thr Glu 
            100                 105                 110         

Thr Val Lys Ala Val Phe Gln Tyr Gly Tyr Lys Asn Ile Arg Asn Ala 
        115                 120                 125             

Ile Glu Tyr Gln Val Gly Gly Gly Leu Asn Ile Thr Asp Thr Leu Ile 
    130                 135                 140                 

Phe Thr Asp Gly Glu Leu Cys Asp Val Phe Tyr Val Pro Asn Ala Asp 
145                 150                 155                 160 

Gln Gly Cys Glu Leu Trp Val Lys Lys Ser His Tyr Lys His Val Pro 
                165                 170                 175     

Asp Tyr Cys Thr Phe Val Phe Asn Val Phe Cys Ala Lys Asp Arg Lys 
            180                 185                 190         

Thr Tyr Asp Ile Phe Asn Glu Glu Cys Val Tyr Asn Gly Glu Pro Trp 
        195                 200                 205             

Leu 
    

<210>   9
<211>   516
<212>   DNA
<213>   Artificial Sequence

<400>   9
atgaatcagc cagattgggc cgatgaagcg gcaaatggtg cacaccaaga cgcctggaag  60
agtctgaaag cggacgttga aaacgtttac tacatggtga aggccaccta taagaatgac  120
ccagtgtggg gcaatgactt cacttgcgtg ggtgttatgg caaatgatgt caacgaggat  180
gagaagagca ttcaagcaga gtttttgttt atgaataatg ctgacacaaa catgcaattc  240
gccactgaaa aggtgactgc tgttaaaatg tatggttaca atagggaaaa cgccttcaga  300
tacgagacgg aggatggcca agttttcaca gacgtcattg catactctga tgacaactgc  360
gatgtcatct acgttcctgg cacagacgga aatgaggaag gttacgaact atggactacg  420
gattacgaca acattctagc caattgttta aataagttta atgagtacgc tgtaggtagg  480
gagacaaggg atgtattcac aagtgcttgc ctagag                            516

<210>   10
<211>   172
<212>   PRT
<213>   Artificial Sequence

<400>   10
Met Asn Gln Pro Asp Trp Ala Asp Glu Ala Ala Asn Gly Ala His Gln 
1               5                   10                  15      

Asp Ala Trp Lys Ser Leu Lys Ala Asp Val Glu Asn Val Tyr Tyr Met 
            20                  25                  30          

Val Lys Ala Thr Tyr Lys Asn Asp Pro Val Trp Gly Asn Asp Phe Thr 
        35                  40                  45              

Cys Val Gly Val Met Ala Asn Asp Val Asn Glu Asp Glu Lys Ser Ile 
    50                  55                  60                  

Gln Ala Glu Phe Leu Phe Met Asn Asn Ala Asp Thr Asn Met Gln Phe 
65                  70                  75                  80  

Ala Thr Glu Lys Val Thr Ala Val Lys Met Tyr Gly Tyr Asn Arg Glu 
                85                  90                  95      

Asn Ala Phe Arg Tyr Glu Thr Glu Asp Gly Gln Val Phe Thr Asp Val 
            100                 105                 110         

Ile Ala Tyr Ser Asp Asp Asn Cys Asp Val Ile Tyr Val Pro Gly Thr 
        115                 120                 125             

Asp Gly Asn Glu Glu Gly Tyr Glu Leu Trp Thr Thr Asp Tyr Asp Asn 
    130                 135                 140                 

Ile Leu Ala Asn Cys Leu Asn Lys Phe Asn Glu Tyr Ala Val Gly Arg 
145                 150                 155                 160 

Glu Thr Arg Asp Val Phe Thr Ser Ala Cys Leu Glu 
                165                 170         

<210>   11
<211>   171
<212>   PRT
<213>   Rhipicephalus appendiculatus

<400>   11
Asn Gln Pro Asp Trp Ala Asp Glu Ala Ala Asn Gly Ala His Gln Asp 
1               5                   10                  15      

Ala Trp Lys Ser Leu Lys Ala Asp Val Glu Asn Val Tyr Tyr Met Val 
            20                  25                  30          

Lys Ala Thr Tyr Lys Asn Asp Pro Val Trp Gly Asn Asp Phe Thr Cys 
        35                  40                  45              

Val Gly Val Met Ala Asn Asp Val Asn Glu Asp Glu Lys Ser Ile Gln 
    50                  55                  60                  

Ala Glu Phe Leu Phe Met Asn Asn Ala Asp Thr Asn Met Gln Phe Ala 
65                  70                  75                  80  

Thr Glu Lys Val Thr Ala Val Lys Met Tyr Gly Tyr Asn Arg Glu Asn 
                85                  90                  95      

Ala Phe Arg Tyr Glu Thr Glu Asp Gly Gln Val Phe Thr Asp Val Ile 
            100                 105                 110         

Ala Tyr Ser Asp Asp Asn Cys Asp Val Ile Tyr Val Pro Gly Thr Asp 
        115                 120                 125             

Gly Asn Glu Glu Gly Tyr Glu Leu Trp Thr Thr Asp Tyr Asp Asn Ile 
    130                 135                 140                 

Leu Ala Asn Cys Leu Asn Lys Phe Asn Glu Tyr Ala Val Gly Arg Glu 
145                 150                 155                 160 

Thr Arg Asp Val Phe Thr Ser Ala Cys Leu Glu 
                165                 170     

