                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
       Sharma, Chandan
       Hemler, Martin E
 
<120>  COMPOSITIONS AND METHODS FOR INHIBITING DHHC-TYPE 
       PALMITOYLTRANSFERASES FOR CANCER TREATMENT

<130>  52095-559001WO

<140>  PCT/US18/63341
<141>  2018-11-30

<150>  US 62/593,571
<151>  2017-12-01

<150>  US 62/653,160
<151>  2018-04-05

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Met Leu Ile Pro Thr His His Phe Arg Asn Ile Glu Arg Lys Pro 
1               5                   10                  15      


Glu Tyr Leu Gln Pro Glu Lys Cys Val Pro Pro Pro Tyr Pro Gly Pro 
            20                  25                  30          


Val Gly Thr Met Trp Phe Ile Arg Asp Gly Cys Gly Ile Ala Cys Ala 
        35                  40                  45              


Ile Val Thr Trp Phe Leu Val Leu Tyr Ala Glu Phe Val Val Leu Phe 
    50                  55                  60                  


Val Met Leu Ile Pro Ser Arg Asp Tyr Val Tyr Ser Ile Ile Asn Gly 
65                  70                  75                  80  


Ile Val Phe Asn Leu Leu Ala Phe Leu Ala Leu Ala Ser His Cys Arg 
                85                  90                  95      


Ala Met Leu Thr Asp Pro Gly Ala Val Pro Lys Gly Asn Ala Thr Lys 
            100                 105                 110         


Glu Phe Ile Glu Ser Leu Gln Leu Lys Pro Gly Gln Val Val Tyr Lys 
        115                 120                 125             


Cys Pro Lys Cys Cys Ser Ile Lys Pro Asp Arg Ala His His Cys Ser 
    130                 135                 140                 


Val Cys Lys Arg Cys Ile Arg Lys Met Asp His His Cys Pro Trp Val 
145                 150                 155                 160 


Asn Asn Cys Val Gly Glu Asn Asn Gln Lys Tyr Phe Val Leu Phe Thr 
                165                 170                 175     


Met Tyr Ile Ala Leu Ile Ser Leu His Ala Leu Ile Met Val Gly Phe 
            180                 185                 190         


His Phe Leu His Cys Phe Glu Glu Asp Trp Thr Lys Cys Ser Ser Phe 
        195                 200                 205             


Ser Pro Pro Thr Thr Val Ile Leu Leu Ile Leu Leu Cys Phe Glu Gly 
    210                 215                 220                 


Leu Leu Phe Leu Ile Phe Thr Ser Val Met Phe Gly Thr Gln Val His 
225                 230                 235                 240 


Ser Ile Cys Thr Asp Glu Thr Gly Ile Glu Gln Leu Lys Lys Glu Glu 
                245                 250                 255     


Arg Arg Trp Ala Lys Lys Thr Lys Trp Met Asn Met Lys Ala Val Phe 
            260                 265                 270         


Gly His Pro Phe Ser Leu Gly Trp Ala Ser Pro Phe Ala Thr Pro Asp 
        275                 280                 285             


Gln Gly Lys Ala Asp Pro Tyr Gln Tyr Val Val 
    290                 295                 


<210>  2
<211>  12705
<212>  DNA
<213>  Homo sapiens

<400>  2
agcgcgtcat caacctgcgc ggcggccgct cctgcagccg cggccgccgc cactgccggg       60

agagctcgat gggcttctcc tgcgcgccgc ccggtgtctg gccgagtcca gagagccgcg      120

gcgcctcgtt ccgaggagcc atcgccgaag cccgaggccg ggtcccgggt tggggactgc      180

aggggaaggc agcggcggcg gcggcgggag ccccaccggg gtctgggact ggggaactgc      240

ctccggcttc acggggcacc taaaaggaag acagcttgca gggttggact ttgccttcca      300

gggaaactga aagaggtgaa gccggaagga tttcctccct aatgaaggca cagatgccag      360

tatggacaga atagcttatg atgcttatcc ccacccacca cttccgaaac attgagcgga      420

aaccagaata cctccagcca gagaagtgtg tcccaccccc ctaccctggt cctgtgggaa      480

ccatgtggtt tatccgtgac ggctgtggca tcgcctgtgc catcgttacc tggtttctgg      540

tcctctatgc ggagttcgtg gtcctctttg tcatgctgat tccatctcga gactacgtgt      600

atagcatcat caacggaatt gtgttcaacc tgctggcctt cttggccctg gcctcccact      660

gccgggccat gctgacggac cccggggcag tgcccaaagg aaatgccact aaagaattca      720

tcgagagttt acagttgaag cctgggcagg tggtgtacaa gtgccccaaa tgctgcagca      780

tcaagcccga ccgagcccac cactgcagtg tttgtaagcg gtgcattcgg aagatggacc      840

accactgtcc ctgggtcaac aactgtgtag gcgagaacaa ccagaagtac ttcgtcctgt      900

ttacaatgta catagctctc atttccttgc acgccctcat catggtggga ttccacttcc      960

tgcattgctt tgaagaagat tggacaaagt gcagctcctt ctctccaccc accacagtga     1020

ttctccttat cctgctgtgc tttgagggcc tgctcttcct cattttcaca tcagtgatgt     1080

ttgggaccca ggtgcactcc atctgcacag atgagacggg aatagaacaa ttgaaaaagg     1140

aagagagaag atgggctaaa aaaacaaaat ggatgaacat gaaagccgtt tttggccacc     1200

ccttctctct aggctgggcc agcccctttg ccacgccaga ccaagggaag gcagacccgt     1260

accagtatgt ggtctgaagg accccgaccg gcatggccac tcagacacaa gtccacacca     1320

cagcactacc gtcccatccg ttctcatgaa tgtttaaatc gaaaaagcaa aacaactact     1380

cttaaaactt tttttatgtc tcaagtaaaa tggctgagca ttgcagagaa aaaaaaaagt     1440

ccccacattt tattttttaa aaaccatcct ttcgatttct tttggtgacc gaagctgctc     1500

tcttttcctt ttaaaatcac ttctctggcc tctggtttct ctctgctgtc tgtctggcat     1560

gactaatgta gagggcgctg tctcgcgctg tgcccattct actaactgag tgagacatga     1620

cgctgtgcgt ggatggaata gtctggacac ctggtggggg atgcatggga aagccaggag     1680

ggccctgacc tcccactgcc caggaggcag tggcgggctc cccgatggga cataaaacct     1740

caccgaagat ggatgcttac cccttgaggc ctgagaaggg caggatcaga agggaccttg     1800

gcacagcgac ctcatccccc aagtggacac ggtttgcctg ctaactcgca aagcaattgc     1860

ctgccttgta ctttatgggc ttggggtgtg tagaatgatt ttgcggggga gtggggagaa     1920

agatgaaaga ggtcttattt gtattctgaa tcagcaatta tattccctgt gattatttgg     1980

aagagtgtgt aggaaagacg tttttccagt tcaaaatgcc ttatacaatc aagaggaaaa     2040

aaaattacac aatttcaggc aagctacgtt ttcctttgtt tcatctgctt cctctctcac     2100

caccccatct ccctctcttc cccagcaaga tgtcaattaa gcagtgtgaa ttctgactgc     2160

aataggcacc agtgcccaac acatacagcc ccaccatcat ccccttctca ttttataaac     2220

ctcaaagtgg attcactttc tgatagttaa cccccataaa tgtgcacgta cctgtgtctt     2280

atctatattt taacctggga gactgttgtc ctggcatgga gatgaccatg atgctggggt     2340

tacctcacag tccccaccct ttcaaagttg acatatggcc atcccattgg ccagaatcca     2400

cagacacacc taagcctgtg gcactgggac agaatagatt ttccatttga gaggcacttc     2460

ctgtgtcagt cttgtttgaa ggaggtggtg atggtggata gaggtgaagg aggtagggag     2520

tgccctccaa gtgcaaaaat aacaaatatg attattgacc atcggggaat tctcacacat     2580

tgatttgttt tttaagcaat tgccagaaac cccctttttt agcttttgct tggggtgggg     2640

gtaggagtta aggtttattc aatcctgtcc tgggtagggc gaaagttaat ctagccatgt     2700

gatttttcag aaaagtaagt ggaacatgct gccacttttc aattctgtca gtgcttccac     2760

atggaaacaa aatgcaataa aatttttcca aaacctgttc tgatttagct ctctcttgag     2820

gtgttaccct tagtgggagg ccgactatcc acaatctact tgagttttct ctggttgggt     2880

gtttgtttca ttgctctgtc tcttgaatga ggatacttta ttttttttgt tttaaaatgc     2940

atttatggtc cctctcttga accagcttgc cccaccaggc ctctttcctt tgctttctgc     3000

agcctgaatc aattcctttg tgctgatggg ctctcctaag agctttcctg agtcagttaa     3060

ctttacctcg tgtctacggt gctattcatg cgatacgggc gaggctgaga tgctaagatt     3120

aaaaagaaaa gaatgctgtt ttagatcaag ttgatagcat ttgttttcca tatgcttttt     3180

taaaattttt tcataacata cagctcagtt aggtgtatga aagaagtgtt attgtattaa     3240

ataactagag cagggctaca gctctggccc tcccctaggg ggaagagatt ggtaatactc     3300

catcttccag ggcatttttt aaagtgagcc aggttagctc ttttcccctg gcatttctca     3360

ggaatgcagt agatagtgct gaagatgcac tgactttttt ttagtcctaa aaatagaaac     3420

tcctccttta aagctgtgca tactatgctt atctttccaa tagagtgggg ttccttcaga     3480

tatcctatag gattctgcct ctggttttgt ataggccttg gctagaaaga gtcaatgttt     3540

ctgagctctc aaaccagttg ctctcagaag ataggaatac cccaaggttc ctggcatttt     3600

tcctatttca tttttgttca gactgatatt ttgccaagag cacaatgact gaggaatgta     3660

gccatcattt gcagggtagt gattggttcc cagcctggct tccacacagg acaggaaggg     3720

aaagcatccc tgagctctcc tcagtatttc cggatgtaat gaaagaggac atctttctac     3780

acaaagtcag ccccaacttt tggcttggtc acaggagttc tgatagtact gtttggtgca     3840

ctcatgggaa attgaaccag tcgtagccac agtctttcag agcctgggct ctggggagtg     3900

gaagtgaaaa ataaagatgt ggcttgttgg attgtgatcc ccagcttgct ttccttctgt     3960

caactctgtc aggtttgtgt tcatagcaac tagactgaat atgcaaaagg cttagatcca     4020

agcaaatcta taatctatgc atatttgcat gggcttggta atatcatgta cacaaaacac     4080

atttgggtag aagtgcatgt gctaaatctc cttttagtcc caccattttg tcttcttcat     4140

actgtacttc ctcttttttg tttgagacaa ggtcttgctc tgtcacccag gctggaatgc     4200

agtggcacaa ttagagctca ctgcagcctt gaactcctgg gctcaagtga ttcttgtgcc     4260

ttggcctcct gaatatccag ggctacaggc acgtactacc atgcctggct aatttttttg     4320

ttttttaata gagtcagggt ctcactgtgt tgccctagct agtctcaaat gcccggcctc     4380

cagcaatttt cctgccttag cctcccaaag tcctgggatt acaggcgtga gccactgggc     4440

ccagccctgt acttcttgaa aaagccccaa gtattagctt ttgctcatct ggctaggcca     4500

cttaaatagt tagaatccac cgtcccctaa tgcagaaacc gtttaggtga ggtaaattaa     4560

caaacatttt aagccgggcg cggacacttc tcactgtgga catccctcac gcctgtaatc     4620

ccagcacttt gggaggccga ggcgggcaga tcacgaggtc aagagatcga gatcatcctg     4680

gctaacacgg tgaaaccctg tctctactaa aaatataaaa aaattagctg ggcgtggtgg     4740

caggcgtctg tagtcccagc tacttgggag gctgaggcag gagaatggcg tgaacccggg     4800

aagtggagct tgcagtgagc caagatcgca ccactgcact ccagcctggg cgacagagtg     4860

agactccgtc tcaaaaaaaa aaaacaaaca ttttaaacat gtatgtgagg ttggcattac     4920

acagaaactc ctctccgggt gggctgggat gggctttctc agccaggcta atgggtttta     4980

aatttctctc ttttcaagac ttgcagtgca tcagcttaaa gggtgagcca gccagtagag     5040

gggaaggcgc cccacctaga aggtgccctt agatatcaaa gaaatgtgaa aagagaaaga     5100

ttttgctaga atcctcctca aaggtgttct tgaggttgcc agaccagcaa cgtcaacatc     5160

agcatcacct gagaacttgt tagaaatgca cattctcggt ccccacccca ggctaccgaa     5220

ccagaaaccg agcggggccc agcagcccgt gtcttaacag ccctccaggt gattctgact     5280

atcaagtttg agaatccagt tggggctagc aggagtcccc cctcaggtgg tccctgatgc     5340

ctgctggtga tatgggtctt gtgtgctgct gggctcagca tagtgcagtt ggggtgtgct     5400

gattgtgaga caggcacgtg ttccctccgc ggagaagcca ctgagactgc cttccctcat     5460

aagctgcggc ctccccaaca aacaactgcc aagacatcaa agaaagtctg tatgaagcag     5520

atccaaatta ttagcctgcc caccactcct tgtgcatctc atcagtggaa cccatctcta     5580

gaccaagggc cctttgggtg aagaagcagc ccggaaggga aagagaaaag agtagaacca     5640

agggacctcc agatgggagc ggcggccggt gagtagtcta gagccagggg cattgtagca     5700

gcctggatac atgacctgaa cacgtcttga cctttgcttt ctacgtgtgg gtttcaacac     5760

ccatgtggct ttttcttgta ttctttaaat atgtatctgg cttaggatca cctcatagaa     5820

gagaaagaat tcacagtgaa gcagaaacaa gccactgacc agcgtactcc caacctgaac     5880

cttctttttc tcaccctctc cctcaagtaa acatcttgct gacttgagca gtgtgattgc     5940

cgtagcaaag cagagtggcc cccagggatc ccgctctgtt gggcccacag gaggagccga     6000

tgaagctgat ccaaggagtg aggacaagcg ctgcagaggg acgttcgcta aaagccttct     6060

aggggccgca catgctctaa cacggacata aggatgccct gaatttctgc agctgaggcc     6120

atatagtctg gtgaccaagt atttgggtcc tggcttcagt ctttggttga aatgtctgct     6180

tggctactta ttaccgcacc tactaccaaa atatgacctt gagcagtaac ttctttaagc     6240

ctcagttttt tcatctgaaa acgggaatga taatctaaat cacaaagtta atggaaggat     6300

taaatgaggg tgatgaatag gaatgtatag cgtctggccc tggtatggct ttataaatgt     6360

tagctgtgtt ggagctgtgc ttttcaaacc attggtcaca gccattcatg gtttgcaacc     6420

agcatgtttt tcaagaaaaa tgtttaatgc attacatatt gcaggataag tattgtttta     6480

tgaagcttag ggagttgtgt gtatatgtgt tctggaatgc aacagaaaaa tgtttcctct     6540

tgtgggttac aatatagagg tatgaaatct ctgatgagga gagacagtgt tatctggccc     6600

gctatgaaga gacacatttg cataggctgc tccctgaggc tctggctttc tacatctgat     6660

gatacaggga gcagggaaca gcctgttctc gttctgtggg gctcagctga gtctgttctg     6720

cacagactct tccttcctcg ggagccttag tcctaataca ttcattttgg agtgttggtg     6780

agtttgttca cagatcacag ctcatgtgtc acccagactg acctgggcca aaaggcccat     6840

cacacaccct gcaagagctt ctggtgtcga ctatgacccc cttaccaggc atcaaccatt     6900

tttgttcgtt ctcttgagcc tgaagctact attactgctc ctctgcaaac ctcaagctta     6960

agaactttgc ctgcaggatc cctttaaatc cacacaaaac tcaaaattga gtcctaccag     7020

gaaaaagcag ccctcagccc atttttatac atcggatttg tttgcaatat tttctttcta     7080

gactcaaaag tcaacactcc ctgaaagttt gtcgacttta ctgctgaaga cctctggtag     7140

acaggccagg ctctgtctgg aatactttat gaggttggtg aggaggttga gtataatcca     7200

agagtgccta tctgggagca tgccacatga atggcaaata atcatcctgt gggctcttgg     7260

cttcattccc cttctctctg actgagctca gcctgggcac agtggtgatt tgcagtagaa     7320

ctggaaacct gttgggcaga aaaaaagaca ctagttctgg ttccagttct gatacataac     7380

aagctagatg agccttggcc accgtcatgg cctcttggaa cttctgtttc ttccccatct     7440

gccaatcatc aatactcata cccacctcct cacaaggagg ccataaaaac ctatggtcat     7500

ggctttgagt ccaagtcagt gtggatgcag ccagtctgtc atttttgggt gtttcctctg     7560

tagccgggtc tgccatatgg tgatgtccca gctctcgtgc tatgaagtta aagcctcttt     7620

ctcaacaggc tgcagatgat cacccaggaa gagaatgcag aatgcccaaa gcaaaccatc     7680

tcagctggtc actgcttctg tgccaagaag ggaggcctgg cgaggggcca gtcaggaagc     7740

agcatggcat cacatgctca tgacccacat gaaggtccct ttagacttgt gtcaacaaga     7800

tccattttct gaaacaacta tttttgttct gattataaaa gtaacattgg ctcattggta     7860

aaacttggat tgtgtgagaa gtctacagaa ataaatacaa atcctctaga attccatccc     7920

caaaagtaac cactcagaca aatgttctaa tgtcatgtaa aaccatatta aaccatcttt     7980

tctagctgca tagtgttata gaatcatttg cttaaccatc attattgggc atttctcatt     8040

tccagctttg cattattata attcagtgtt caagtttgta ttgcataaat ctttgtctca     8100

gattattgat tatttttaaa ctttttgtga aatcagactt acaaaaatgt gacaaaaaca     8160

gtacaaagag ttcccatgta cctttcagtc agtctcacca aaggtaaaca ttttatacaa     8220

ccataataca aatataaaac cctggacatt ggcaacacca tacccttaac taatgtatgt     8280

accttattca catttctcca gttgtcccat taacaccctt ttctgttcca ggatcccaca     8340

ctgcatcatt tgcgatgtct ccttagtctc ctccagtttg tgacagttcc tcagtcttcc     8400

tttgtctttc atgaccttga ccctttttaa aaatcgaggt gaaattcctg taacacaaaa     8460

ttagccattt taaagtgtac atttaatgca ttcacaatgt tttgtaacca ccaggtctgt     8520

ctggttccaa aatcttttca tcaatctttg acccttttga agattgtagg gcaggtattc     8580

tgtaggctgt ccttcagatt gtgtttttga tgtttttctc atgattagat tgaggttagg     8640

catttggggc aggagcactg ctgaagcaat gtgtcctcgt tgcaccgtat caggaggcat     8700

atggtgttga tacgtttcat tattgtgatg ttaactttga tcattgggtg aaggtggtac     8760

gtgcaatgtt tcttccctgc tattaaggta ctgtttttcc ctttgtaatt gataagtatc     8820

ttatgaggat atacttttga gatccaattt ttttaactta gaatttattc aaaagtcaag     8880

aatcttaaat ctctgaaatg gcgtgggaag aaaaagtgct agatacacag agatctttct     8940

tgagtcatgt gaaggagcag tgcccaagcc cagcaaaccc acagcaaatt cccttggctt     9000

ccagaagaga tggagaaagc agtgccccca gtggagggtc aaaggcctct gtgcagggtg     9060

ttgtgggcct ggagagctgg cctggccatg tctttacctc ctctgggcat ctccccaccc     9120

caacaccctt tctgtggcct ggtggctgag ttgcagccga cacccagagg caggtgagtt     9180

gacagcttgg aagaggctgc agggtggatc tgctgcatga gcaggcctga gcccagcctt     9240

acctccccac agtggtcctg tgtgccctcc ggctgcctaa tgcatgttgg cacttgctgt     9300

acgagcaccc gcttcttcac ctcgcatgct gtttgtgtcc tgcactcctt ccttaacccc     9360

atcgtccttc tgctgtgttt gcagccccta tctaccctgg tgggagtggc caaaaatatt     9420

taggagggga tcaccagttt gtagtggcct cagaggatgt gtggtccccc ttatgcctca     9480

gccactcatc agcctagccc ctgcccatca tctggcattg cacttgtgga aggaaagaag     9540

gggagggctg ggtggtgggt ggagaacacg tcagtccacc aggcgggccc tgcttgctgt     9600

gttcctccac gctgctgtcc acccacaccc cagcagtcct ctgagggacc tcccgggggt     9660

gacctgggcc acaacagact gcccactcag accccatctt acccatgccg tggacacccc     9720

gccccccccc ccgccactgc tatgctatag ctgggggtgt ctatgtgagc tgtacagccc     9780

agcaccacgc tgacgatgtt cttcatcccc ttctccctgc agggcatcga gcgcctcaaa     9840

cgaaagaacc agcccaggga gcacatgggg agctggcagt cagtaaagga gacctttggt     9900

ggggacttct ccctgaactg gttcaacccc ttctccagac cgtgtcagcc agagatcccc     9960

agtgacaaag acatggtgcg gcaggtgaca tcgctgtcag acaccgaaac aatggaggat    10020

ccatcagagg agacaaagga cgaggactct gtggaggtga cagatgaata gatgctgctg    10080

tggggagaga agcaaacact aaaaagtgct gtcaaccttc atcctggggt tttggctaaa    10140

ggggcttatg ggcatggtgc gctcccagca cccccagtgc ttcccttagc cactcgcttg    10200

gccttgccat ttcccctcct tcttctctcc atgttgggcc aggtctgggg gtcgggagta    10260

ggctggggac atcagaggag gatgggggct ttctcagagt tcatctaaga agagtctgca    10320

ctgagacggc tcatcaagaa ccgttctcca agactgggtg gctttcacat tctccgccca    10380

gcaaagggag cttttgaaca gggcatccca ggggcagaaa agagcttgcc tttggctttc    10440

cccaggattt ctgtcttctc ttgggaaggc tgggcccctg gctcctggct ttgagaagta    10500

aggttgtgac agaaggaccg ggcagggctt gccttgggga cctgggttgg gacactgaca    10560

tcaggggaga ctagcctgga aagactgcag agctgccagc tactccctgg aaagggcttc    10620

cccatgctgc ctgccgaaat taggaggtag aggtggctgc cacatctacc tgcaagggcc    10680

aggcatggtt caaagaggac cctgcattaa gctctacaca cacatgtgca ggacatgtcc    10740

agcatggaca gagccagagt taagacagta gcaccgaaaa tgagccccca ttccacagac    10800

actggagtct tcactgagcg agacagctgg gagctgtcct gcctgtggct acatatctag    10860

ccattcacag atgtggatat gggaaggacc tctttggagc tactggggac tccctaacca    10920

ctcgcatgag aacttaattg aatgttacct cttggaggga gtctaataac acatgtaggt    10980

agaactgacc ataaaccctg cctgtgtgtt tgaaaaggcc agttctccca aattggtgcc    11040

catcttgtct ctgaaaagat gggtgatggc cagggtctgc tgattgatga atcagatgaa    11100

tcaggaagat agacaaacac acacacacac acacacaccc caccaggatg agtctgccct    11160

ctattcaccc catttgaagc ctgtggtgtc tgtgaccact gctgaaggtc tgagcagcgt    11220

tctggtgctc ctaaacccca ttccagtggt tgctgaagca gcatcttctg cacaaagccc    11280

aacagaaggg ttcttatccc cgtttggtat aagaagtgga ttcaccaccc actccctcca    11340

cgtgcctttg ttcctctctt tggcccattt ccccagcgtc tactggcgtc aggattggca    11400

ggagcacagg cactcagcag agcatgcccc tgcaagacct cagtgttagg gccccccttc    11460

cagctccagg caaaagggca tgagtcctgg ccccaagggg cctgtggctg cagttcagag    11520

gagaagaagg tcagtgtttg gaggtgcagc ctcaggatgc tgagaaagga aactggcgac    11580

cgtgagaaag aaaagagcca agcagcatcc tggttcttgg acagcatctt tggacactct    11640

gtgaagggca acgatcctgc cagagaccgt ctctctacaa ctgatgaccc actagggcct    11700

ggggttaatt gctcaaaggg cccagtgttc acaaagccac ctctgcccta acccttgcca    11760

gagctctcca actatgaccc acgagagggg tgatggtggg attctaacat caacagagca    11820

accagaaaga cattgggcct cccacactca ggctgcaggc ccactttctt ggtccttatc    11880

agctttaata tttattaatg acgacatagg agcccgagtc agctgtaaag gccattaact    11940

tgcaatctgg acaggaagtt gacgctcacc actttgggta agagctgctc tgactgtagg    12000

gccccctatt tgttgtccta acccagaagc agctctgggc tgccaggatg gtggatggaa    12060

taccagagag ttcacactag ggaggaagca atgcctgccc cctggagtct cctagggggc    12120

agcagttaga ataagggaag aggatttgct ggtcactgtt tgctgacatg ggtttccatg    12180

gtgagttcag gcctgaggac agcagtgtct gcaaaaccac atggcccttg agaaatgtcc    12240

ttgcacattg ggcttcaaac tcctcttcta gggaatccat cttggcctga aagcagaggt    12300

acaacaccag ccccaaaggc aattctgttt tcagattggt tgctctggaa aggaaggctg    12360

gggtgagggg gcattttact tgcacagagg ctgaccctgc ctcccctctt cactgacccc    12420

atctccaagg tagacctcag ccatgtcagt ccctgttctg ggaggtgctg ggctgggcca    12480

cagccagggt tatgtaggta attaacctgt ccaaccctga gcctcgcctc cccacaccag    12540

caacacagtg gtctctctgt ggtgaccatt cacagcataa cattctgctt agcctcagac    12600

tgaaagcatt gcaactgatg tcaaaaccag atgagatctt acagggagag agattgggtg    12660

caatttgcct ctttctttga ataaaaagct ctttgctcac cctca                    12705


<210>  3
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Asn Gly Ala Val Tyr Ser Pro Thr Thr Glu Glu Asp Pro Gly 
1               5                   10                  15      


Pro Ala Arg Gly Pro Arg Ser Gly Leu Ala Ala Tyr Phe Phe Met Gly 
            20                  25                  30          


Arg Leu Pro Leu Leu Arg Arg Val Leu Lys Gly Leu Gln Leu Leu Leu 
        35                  40                  45              


Ser Leu Leu Ala Phe Ile Cys Glu Glu Val Val Ser Gln Cys Thr Leu 
    50                  55                  60                  


Cys Gly Gly Leu Tyr Phe Phe Glu Phe Val Ser Cys Ser Ala Phe Leu 
65                  70                  75                  80  


Leu Ser Leu Leu Ile Leu Ile Val Tyr Cys Thr Pro Phe Tyr Glu Arg 
                85                  90                  95      


Val Asp Thr Thr Lys Val Lys Ser Ser Asp Phe Tyr Ile Thr Leu Gly 
            100                 105                 110         


Thr Gly Cys Val Phe Leu Leu Ala Ser Ile Ile Phe Val Ser Thr His 
        115                 120                 125             


Asp Arg Thr Ser Ala Glu Ile Ala Ala Ile Val Phe Gly Phe Ile Ala 
    130                 135                 140                 


Ser Phe Met Phe Leu Leu Asp Phe Ile Thr Met Leu Tyr Glu Lys Arg 
145                 150                 155                 160 


Gln Glu Ser Gln Leu Arg Lys Pro Glu Asn Thr Thr Arg Ala Glu Ala 
                165                 170                 175     


Leu Thr Glu Pro Leu Asn Ala 
            180             


<210>  4
<211>  3384
<212>  DNA
<213>  Homo sapiens

<400>  4
agggggcggg gcgggccaag ggcgggggcg ggaaggggcg gagtcaggcg gaagccgggg       60

agaaggccca ggaagtgacg gccgcctccc ggctaccggg gacttctgga gtccgagaag      120

tcaacggcgc ggttgctgcg gccgccgcgc tccccggccc gaggcgatgg agaacggagc      180

ggtgtacagc cccactacgg aggaggaccc gggccccgcc agaggccccc ggagcggcct      240

cgctgcctac tttttcatgg gccggctccc attgctccgg cgcgttctca agggcttgca      300

gctgttgctg tctctgctgg ccttcatctg tgaagaagtt gtatcacaat gtactttatg      360

tggaggactt tatttttttg agtttgtaag ctgcagtgcc tttcttctga gtctccttat      420

actgattgtg tattgcactc cattttatga gagagttgat accacaaaag taaaatcatc      480

ggatttttat attactttgg gaacaggatg tgtgtttttg ttggcatcca tcatttttgt      540

ttccacacat gacaggactt cagctgagat tgctgcaatt gtgtttggat ttatagcaag      600

ttttatgttc ctacttgact ttatcactat gctgtatgaa aaacgacagg agtcccagct      660

gagaaaacct gaaaatacca ctagggctga agccctcact gagccactta atgcctaaag      720

actctgggga gcagatgtta cctaaggtag tgaccctgca ttgtggtgcc tgagccctgg      780

cagaagctct tgtaaaattt gttaattgtt taaaccactt cttttggaga gcaaggggaa      840

ggtcaagaag gcagttttat caatattgtg tcagtcacca caaagtaggc cagataagtt      900

aaaaaaaatt tttttttaaa taataattga aacttatctc aaatggagat tttggtggga      960

ggaggagaaa acaattgttt ttaaatcaca cagctcaacg gttgataaat gattctgtca     1020

ttctgttaca ggtcattctt ttactaggct tagcttccaa attatgcttt atagctgtat     1080

aaacatcgtg attatattca tctacttaga aattgtttta tttttaaatt aatttgctta     1140

gctgtttgtt ttgatgctta gattatgttc tgttaatggg aatttaacat atttaagaaa     1200

ccaatattta aaatgttggt ctaggttttt ttccttaaca tatattacca ggctttactg     1260

tatttcactc agccttaaat gttataatat ttttggataa cggttattaa ttctttgaga     1320

ccttcgtata gcctataaaa tgtatgggag atgttggtat tttatgtgta taaaagcaac     1380

aatatcagca acttcgtgtt tatactgcac cttggttgtt gatgtcaagt aaaaaaaaga     1440

ttgttttgta acacataaaa aaatggaaga aactgatacc acacctaagg accaaagata     1500

agaaagactt tttgcccaag acagtgaaag taattataaa aacaagcttt gaccacttac     1560

caagtatctg aagagatgag ttcatactat gatttagaaa gtggttcaat tcccctgttg     1620

gcatatgatt atttttacta aaattaatac agctctgtgg gtcttcctta gtgttttctt     1680

tgaagccaat ctgttttttt taggacacca gcctttggtt tttcatctgt tcgagatgcc     1740

tcttctctgt ctccttatca gatagaaatg gagtcatgtg ctgctgcttc atctagcaga     1800

ggttggcctc tggctctgac actttttgtc agttgtcttt aggtggtcct gaatcttggg     1860

cccttttgat tgtgaatact gtgtagcagg atcttgagag tccttgttct tacataggca     1920

ttgctctagt ttgtctttgg caaaaaaaaa aaaaaaaaaa agtaaatatc cagggaaccc     1980

tgcccagact aatactgttg gtggcataag agaatcaagc cattctcaag agataacttc     2040

ataaccagaa ttgtctgttg gctagcagct gtcacagata ggcagggcac ttgggatatg     2100

acctttctgt ccaggtgatt cacagactag acctttctta tcctcctcct agagttttga     2160

cttgggactc tagtgttaag atgatgagcc cgtgcatcag gtccttctgc actttggtgg     2220

aagtctccca gggtaggttt cctatttgaa acagtggaat catgtttcca gtgataaagt     2280

ttaatgacct catccttttt tttttttctc atctgccatt tgtgtgtctt agatgggttt     2340

taattgcatg aatgtggcta atgtggttct cagaaattgg tcagtatggc ccaacatagc     2400

ttctgctctg tcttactgac tcaatacctt taggatttgt atcagagttt ggatactagt     2460

gttagtggtg gtgtcaccac tacttaattg ggagataatg aaaccaatca tggatgctgt     2520

ttttattggg catgtcatct aagagaggag aaatagctgg gttttgggtc taattatgaa     2580

taaggactga ttcagaaaac gagtttatgg taggtagact aaagtttcac atcagactgt     2640

accattgtga tttagaccta tctaaaattc agagcatatc atctgggcta cctcagggtc     2700

accacccatg tattgggctt agtcaggatt gacagataca ttctcagctg gcctgtcata     2760

taaaacatac tgtcattgag cttaagctcc gcttgttctg aggtttcacc tccatgtgtt     2820

tcattggtgc aaaagtggat ctcttagttg gtcacttaat tctttctttt tcagaaagat     2880

agtatgttca ctggtatatt tggtcactct tagaaccttc cttcacattg ttttttatgg     2940

gacccatgaa tggttagcct ttcttttcta ttgtagaagg aaataaatag gagtaaaaag     3000

accattgtag taaataagtt caaggggaac ttgggaccag aaaccactgt tatgtacaaa     3060

aaaatggcaa attcaataaa ctcaaattta aaataatttt taaattaaca gttatgataa     3120

attttatatt ttatacaaat agattgctta gaatggttct caagaattat aagagaaatg     3180

aactcacagt acaaaaattt tataattact atacttgtgt tttgtttggg ggctgggaaa     3240

tgtattttta cattgtagcc aatcatttta tatttgtcaa tttaaatctt atgggtcttt     3300

tttttttatc tctcttgatg tcagatttta tagtcttttt aaataaatcc atttaattaa     3360

aacgttaaaa aaaaaaaaaa aaaa                                            3384


<210>  5
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  6
<211>  873
<212>  DNA
<213>  Homo sapiens

<400>  6
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact       60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc      120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag      180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc      240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag      300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt      360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga      420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac      480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc      540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac      600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat      660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggactcac      720

ttggtaattc tgggagccat cttattatgc cttggtgtag cactgacatt catcttccgt      780

ttaagaaaag ggagaatgat ggatgtgaaa aaatgtggca tccaagatac aaactcaaag      840

aagcaaagtg atacacattt ggaggagacg taa                                   873