                         SEQUENCE LISTING

<110>  President and Fellows of Harvard College
 
<120>  METHODS AND COMPOSITIONS FOR THE PRODUCTION OF OLIGODENDROCYTE
       PROGENITOR CELLS

<130>  H0498.70650WO00

<140>  Not Yet Assigned
<141>  Concurrently herewith

<150>  US 62/624,000
<151>  2018-01-30

<150>  US 62/593,560
<151>  2017-12-01

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  1101
<212>  DNA
<213>  Homo sapiens

<400>  1
atgttagcgg tgggggcaat ggagggcacc cggcagagcg cattcctgct cagcagccct       60

cccctggccg ccctgcacag catggccgag atgaagaccc cgctgtaccc tgccgcgtat      120

cccccgctgc ctgccggccc cccctcctcc tcgtcctcgt cgtcgtcctc ctcgtcgccc      180

tccccgcctc tgggcaccca caacccaggc ggcctgaagc ccccggccac gggggggctc      240

tcatccctcg gcagcccccc gcagcagctc tcggccgcca ccccacacgg catcaacgat      300

atcctgagcc ggccctccat gcccgtggcc tcgggggccg ccctgccctc cgcctcgccc      360

tccggttcct cctcctcctc ttcctcgtcc gcctctgcct cctccgcctc tgccgccgcc      420

gcggctgctg ccgcggccgc agccgccgcc tcatccccgg cggggctgct ggccggactg      480

ccacgcttta gcagcctgag cccgccgccg ccgccgcccg ggctctactt cagccccagc      540

gccgcggccg tggccgccgt gggccggtac cccaagccgc tggctgagct gcctggccgg      600

acgcccatct tctggcccgg agtgatgcag agcccgccct ggagggacgc acgcctggcc      660

tgtacccctc atcaaggatc cattttgttg gacaaagacg ggaagagaaa acacacgaga      720

cccacttttt ccggacagca gatcttcgcc ctggagaaga ctttcgaaca aacaaaatac      780

ttggcggggc ccgagagggc tcgtttggcc tattcgttgg ggatgacaga gagtcaggtc      840

aaggtctggt tccagaaccg ccggaccaag tggaggaaga agcacgctgc cgagatggcc      900

acggccaaga agaagcagga ctcggagaca gagcgcctca agggggcctc ggagaacgag      960

gaagaggacg acgactacaa taagcctctg gatcccaact cggacgacga gaaaatcacg     1020

cagctgttga agaagcacaa gtccagcagc ggcggcggcg gcggcctcct actgcacgcg     1080

tccgagccgg agagctcatc c                                               1101


<210>  2
<211>  1527
<212>  DNA
<213>  Homo sapiens

<400>  2
atgaatctcc tggacccctt catgaagatg accgacgagc aggagaaggg cctgtccggc       60

gcccccagcc ccaccatgtc cgaggactcc gcgggctcgc cctgcccgtc gggctccggc      120

tcggacaccg agaacacgcg gccccaggag aacacgttcc ccaagggcga gcccgatctg      180

aagaaggaga gcgaggagga caagttcccc gtgtgcatcc gcgaggcggt cagccaggtg      240

ctcaaaggct acgactggac gctggtgccc atgccggtgc gcgtcaacgg ctccagcaag      300

aacaagccgc acgtcaagcg gcccatgaac gccttcatgg tgtgggcgca ggcggcgcgc      360

aggaagctcg cggaccagta cccgcacttg cacaacgccg agctcagcaa gacgctgggc      420

aagctctgga gacttctgaa cgagagcgag aagcggccct tcgtggagga ggcggagcgg      480

ctgcgcgtgc agcacaagaa ggaccacccg gattacaagt accagccgcg gcggaggaag      540

tcggtgaaga acgggcaggc ggaggcagag gaggccacgg agcagacgca catctccccc      600

aacgccatct tcaaggcgct gcaggccgac tcgccacact cctcctccgg catgagcgag      660

gtgcactccc ccggcgagca ctcggggcaa tcccagggcc caccgacccc acccaccacc      720

cccaaaaccg acgtgcagcc gggcaaggct gacctgaagc gagaggggcg ccccttgcca      780

gaggggggca gacagccccc tatcgacttc cgcgacgtgg acatcggcga gctgagcagc      840

gacgtcatct ccaacatcga gaccttcgat gtcaacgagt ttgaccagta cctgccgccc      900

aacggccacc cgggggtgcc ggccacgcac ggccaggtca cctacacggg cagctacggc      960

atcagcagca ccgcggccac cccggcgagc gcgggccacg tgtggatgtc caagcagcag     1020

gcgccgccgc cacccccgca gcagccccca caggccccgc cggccccgca ggcgcccccg     1080

cagccgcagg cggcgccccc acagcagccg gcggcacccc cgcagcagcc acaggcgcac     1140

acgctgacca cgctgagcag cgagccgggc cagtcccagc gaacgcacat caagacggag     1200

cagctgagcc ccagccacta cagcgagcag cagcagcact cgccccaaca gatcgcctac     1260

agccccttca acctcccaca ctacagcccc tcctacccgc ccatcacccg ctcacagtac     1320

gactacaccg accaccagaa ctccagctcc tactacagcc acgcggcagg ccagggcacc     1380

ggcctctact ccaccttcac ctacatgaac cccgctcagc gccccatgta cacccccatc     1440

gccgacacct ctggggtccc ttccatcccg cagacccaca gcccccagca ctgggaacaa     1500

cccgtctaca cacagctcac tcgacct                                         1527


<210>  3
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  3
atggacacta accgcccggg cgcgttcgtg ctgagcagtg ccccgctggc cgcgctgcac       60

aacatggccg agatgaagac gtcgctgttc ccctacgcgc tgcagggtcc ggccggcttc      120

aaggcgcccg cgctgggggg cctgggcgcg cagctcccgc tcgggacccc gcacggcatc      180

agcgacatcc tgggccggcc cgtgggcgcg gcgggcgggg gcctcctggg ggggctgccc      240

cggctcaacg ggctcgcgtc gtccgccggc gtttacttcg ggcccgcggc cgctgtggcg      300

cgcggctacc ccaagcccct ggccgagctg ccggggcgcc cgcccatctt ctggcccggc      360

gtggtgcagg gcgcgccctg gagggacccg cgtctggctg gcccggcccc ggccggcggc      420

gtcctggaca aggacgggaa gaagaagcac tcgcgcccga ccttctcggg ccagcagatc      480

ttcgcgctgg agaaaacctt cgagcagacc aagtacctgg cgggcccgga gcgcgcgcgt      540

ctcgcctact cgctgggcat gaccgagagc caggtgaagg tctggttcca gaaccgccgg      600

accaagtggc gcaagcggca cgcggtggag atggcgtcgg ccaagaagaa gcaggactcg      660

gacgccgaga agctgaaggt gggcggctcg gacgcggagg acgacgacga atacaaccgg      720

cccctggacc ccaactcgga cgacgagaag atcacgcggc tgctcaagaa gcacaaaccc      780

tcgaacttgg cgctggtcag cccgtgcggc ggcggcgcgg gggacgcctt g               831


<210>  4
<211>  969
<212>  DNA
<213>  Homo sapiens

<400>  4
atggactcgg acgccagcct ggtgtccagc cgcccgtcgt cgccagagcc cgatgacctt       60

tttctgccgg cccggagtaa gggcagcagc ggcagcgcct tcactggggg caccgtgtcc      120

tcgtccaccc cgagtgactg cccgccggag ctgagcgccg agctgcgcgg cgctatgggc      180

tctgcgggcg cgcatcctgg ggacaagcta ggaggcagtg gcttcaagtc atcctcgtcc      240

agcacctcgt cgtctacgtc gtcggcggct gcgtcgtcca ccaagaagga caagaagcaa      300

atgacagagc cggagctgca gcagctgcgt ctcaagatca acagccgcga gcgcaagcgc      360

atgcacgacc tcaacatcgc catggatggc ctccgcgagg tcatgccgta cgcacacggc      420

ccttcggtgc gcaagctttc caagatcgcc acgctgctgc tggcgcgcaa ctacatcctc      480

atgctcacca actcgctgga ggagatgaag cgactggtga gcgagatcta cgggggccac      540

cacgctggct tccacccgtc ggcctgcggc ggcctggcgc actccgcgcc cctgcccgcc      600

gccaccgcgc acccggcagc agcagcgcac gccgcacatc accccgcggt gcaccacccc      660

atcctgccgc ccgccgccgc agcggctgct gccgccgctg cagccgcggc tgtgtccagc      720

gcctctctgc ccggatccgg gctgccgtcg gtcggctcca tccgtccacc gcacggccta      780

ctcaagtctc cgtctgctgc cgcggccgcc ccgctggggg gcgggggcgg cggcagtggg      840

gcgagcgggg gcttccagca ctggggcggc atgccctgcc cctgcagcat gtgccaggtg      900

ccgccgccgc accaccacgt gtcggctatg ggcgccggca gcctgccgcg cctcacctcc      960

gacgccaag                                                              969


<210>  5
<211>  1083
<212>  DNA
<213>  Homo sapiens

<400>  5
atggcgggac acctggcttc agattttgcc ttctcgcccc ctccaggtgg tggaggtgat       60

gggccagggg ggccggagcc gggctgggtt gatcctcgga cctggctaag cttccaaggc      120

cctcctggag ggccaggaat cgggccgggg gttgggccag gctctgaggt gtgggggatt      180

cccccatgcc ccccgccgta tgagttctgt ggggggatgg cgtactgtgg gccccaggtt      240

ggagtggggc tagtgcccca aggcggcttg gagacctctc agcctgaggg cgaagcagga      300

gtcggggtgg agagcaactc cgatggggcc tccccggagc cctgcaccgt cacccctggt      360

gccgtgaagc tggagaagga gaagctggag caaaacccgg aggagtccca ggacatcaaa      420

gctctgcaga aagaactcga gcaatttgcc aagctcctga agcagaagag gatcaccctg      480

ggatatacac aggccgatgt ggggctcacc ctgggggttc tatttgggaa ggtattcagc      540

caaacgacca tctgccgctt tgaggctctg cagcttagct tcaagaacat gtgtaagctg      600

cggcccttgc tgcagaagtg ggtggaggaa gctgacaaca atgaaaatct tcaggagata      660

tgcaaagcag aaaccctcgt gcaggcccga aagagaaagc gaaccagtat cgagaaccga      720

gtgagaggca acctggagaa tttgttcctg cagtgcccga aacccacact gcagcagatc      780

agccacatcg cccagcagct tgggctcgag aaggatgtgg tccgagtgtg gttctgtaac      840

cggcgccaga agggcaagcg atcaagcagc gactatgcac aacgagagga ttttgaggct      900

gctgggtctc ctttctcagg gggaccagtg tcctttcctc tggccccagg gccccatttt      960

ggtaccccag gctatgggag ccctcacttc actgcactgt actcctcggt ccctttccct     1020

gagggggaag cctttccccc tgtctctgtc accactctgg gctctcccat gcattcaaac     1080

tga                                                                   1083


<210>  6
<211>  367
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Ala Val Gly Ala Met Glu Gly Thr Arg Gln Ser Ala Phe Leu 
1               5                   10                  15      


Leu Ser Ser Pro Pro Leu Ala Ala Leu His Ser Met Ala Glu Met Lys 
            20                  25                  30          


Thr Pro Leu Tyr Pro Ala Ala Tyr Pro Pro Leu Pro Ala Gly Pro Pro 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Ser Pro Pro Leu 
    50                  55                  60                  


Gly Thr His Asn Pro Gly Gly Leu Lys Pro Pro Ala Thr Gly Gly Leu 
65                  70                  75                  80  


Ser Ser Leu Gly Ser Pro Pro Gln Gln Leu Ser Ala Ala Thr Pro His 
                85                  90                  95      


Gly Ile Asn Asp Ile Leu Ser Arg Pro Ser Met Pro Val Ala Ser Gly 
            100                 105                 110         


Ala Ala Leu Pro Ser Ala Ser Pro Ser Gly Ser Ser Ser Ser Ser Ser 
        115                 120                 125             


Ser Ser Ala Ser Ala Ser Ser Ala Ser Ala Ala Ala Ala Ala Ala Ala 
    130                 135                 140                 


Ala Ala Ala Ala Ala Ala Ser Ser Pro Ala Gly Leu Leu Ala Gly Leu 
145                 150                 155                 160 


Pro Arg Phe Ser Ser Leu Ser Pro Pro Pro Pro Pro Pro Gly Leu Tyr 
                165                 170                 175     


Phe Ser Pro Ser Ala Ala Ala Val Ala Ala Val Gly Arg Tyr Pro Lys 
            180                 185                 190         


Pro Leu Ala Glu Leu Pro Gly Arg Thr Pro Ile Phe Trp Pro Gly Val 
        195                 200                 205             


Met Gln Ser Pro Pro Trp Arg Asp Ala Arg Leu Ala Cys Thr Pro His 
    210                 215                 220                 


Gln Gly Ser Ile Leu Leu Asp Lys Asp Gly Lys Arg Lys His Thr Arg 
225                 230                 235                 240 


Pro Thr Phe Ser Gly Gln Gln Ile Phe Ala Leu Glu Lys Thr Phe Glu 
                245                 250                 255     


Gln Thr Lys Tyr Leu Ala Gly Pro Glu Arg Ala Arg Leu Ala Tyr Ser 
            260                 265                 270         


Leu Gly Met Thr Glu Ser Gln Val Lys Val Trp Phe Gln Asn Arg Arg 
        275                 280                 285             


Thr Lys Trp Arg Lys Lys His Ala Ala Glu Met Ala Thr Ala Lys Lys 
    290                 295                 300                 


Lys Gln Asp Ser Glu Thr Glu Arg Leu Lys Gly Ala Ser Glu Asn Glu 
305                 310                 315                 320 


Glu Glu Asp Asp Asp Tyr Asn Lys Pro Leu Asp Pro Asn Ser Asp Asp 
                325                 330                 335     


Glu Lys Ile Thr Gln Leu Leu Lys Lys His Lys Ser Ser Ser Gly Gly 
            340                 345                 350         


Gly Gly Gly Leu Leu Leu His Ala Ser Glu Pro Glu Ser Ser Ser 
        355                 360                 365         


<210>  7
<211>  509
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asn Leu Leu Asp Pro Phe Met Lys Met Thr Asp Glu Gln Glu Lys 
1               5                   10                  15      


Gly Leu Ser Gly Ala Pro Ser Pro Thr Met Ser Glu Asp Ser Ala Gly 
            20                  25                  30          


Ser Pro Cys Pro Ser Gly Ser Gly Ser Asp Thr Glu Asn Thr Arg Pro 
        35                  40                  45              


Gln Glu Asn Thr Phe Pro Lys Gly Glu Pro Asp Leu Lys Lys Glu Ser 
    50                  55                  60                  


Glu Glu Asp Lys Phe Pro Val Cys Ile Arg Glu Ala Val Ser Gln Val 
65                  70                  75                  80  


Leu Lys Gly Tyr Asp Trp Thr Leu Val Pro Met Pro Val Arg Val Asn 
                85                  90                  95      


Gly Ser Ser Lys Asn Lys Pro His Val Lys Arg Pro Met Asn Ala Phe 
            100                 105                 110         


Met Val Trp Ala Gln Ala Ala Arg Arg Lys Leu Ala Asp Gln Tyr Pro 
        115                 120                 125             


His Leu His Asn Ala Glu Leu Ser Lys Thr Leu Gly Lys Leu Trp Arg 
    130                 135                 140                 


Leu Leu Asn Glu Ser Glu Lys Arg Pro Phe Val Glu Glu Ala Glu Arg 
145                 150                 155                 160 


Leu Arg Val Gln His Lys Lys Asp His Pro Asp Tyr Lys Tyr Gln Pro 
                165                 170                 175     


Arg Arg Arg Lys Ser Val Lys Asn Gly Gln Ala Glu Ala Glu Glu Ala 
            180                 185                 190         


Thr Glu Gln Thr His Ile Ser Pro Asn Ala Ile Phe Lys Ala Leu Gln 
        195                 200                 205             


Ala Asp Ser Pro His Ser Ser Ser Gly Met Ser Glu Val His Ser Pro 
    210                 215                 220                 


Gly Glu His Ser Gly Gln Ser Gln Gly Pro Pro Thr Pro Pro Thr Thr 
225                 230                 235                 240 


Pro Lys Thr Asp Val Gln Pro Gly Lys Ala Asp Leu Lys Arg Glu Gly 
                245                 250                 255     


Arg Pro Leu Pro Glu Gly Gly Arg Gln Pro Pro Ile Asp Phe Arg Asp 
            260                 265                 270         


Val Asp Ile Gly Glu Leu Ser Ser Asp Val Ile Ser Asn Ile Glu Thr 
        275                 280                 285             


Phe Asp Val Asn Glu Phe Asp Gln Tyr Leu Pro Pro Asn Gly His Pro 
    290                 295                 300                 


Gly Val Pro Ala Thr His Gly Gln Val Thr Tyr Thr Gly Ser Tyr Gly 
305                 310                 315                 320 


Ile Ser Ser Thr Ala Ala Thr Pro Ala Ser Ala Gly His Val Trp Met 
                325                 330                 335     


Ser Lys Gln Gln Ala Pro Pro Pro Pro Pro Gln Gln Pro Pro Gln Ala 
            340                 345                 350         


Pro Pro Ala Pro Gln Ala Pro Pro Gln Pro Gln Ala Ala Pro Pro Gln 
        355                 360                 365             


Gln Pro Ala Ala Pro Pro Gln Gln Pro Gln Ala His Thr Leu Thr Thr 
    370                 375                 380                 


Leu Ser Ser Glu Pro Gly Gln Ser Gln Arg Thr His Ile Lys Thr Glu 
385                 390                 395                 400 


Gln Leu Ser Pro Ser His Tyr Ser Glu Gln Gln Gln His Ser Pro Gln 
                405                 410                 415     


Gln Ile Ala Tyr Ser Pro Phe Asn Leu Pro His Tyr Ser Pro Ser Tyr 
            420                 425                 430         


Pro Pro Ile Thr Arg Ser Gln Tyr Asp Tyr Thr Asp His Gln Asn Ser 
        435                 440                 445             


Ser Ser Tyr Tyr Ser His Ala Ala Gly Gln Gly Thr Gly Leu Tyr Ser 
    450                 455                 460                 


Thr Phe Thr Tyr Met Asn Pro Ala Gln Arg Pro Met Tyr Thr Pro Ile 
465                 470                 475                 480 


Ala Asp Thr Ser Gly Val Pro Ser Ile Pro Gln Thr His Ser Pro Gln 
                485                 490                 495     


His Trp Glu Gln Pro Val Tyr Thr Gln Leu Thr Arg Pro 
            500                 505                 


<210>  8
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Thr Asn Arg Pro Gly Ala Phe Val Leu Ser Ser Ala Pro Leu 
1               5                   10                  15      


Ala Ala Leu His Asn Met Ala Glu Met Lys Thr Ser Leu Phe Pro Tyr 
            20                  25                  30          


Ala Leu Gln Gly Pro Ala Gly Phe Lys Ala Pro Ala Leu Gly Gly Leu 
        35                  40                  45              


Gly Ala Gln Leu Pro Leu Gly Thr Pro His Gly Ile Ser Asp Ile Leu 
    50                  55                  60                  


Gly Arg Pro Val Gly Ala Ala Gly Gly Gly Leu Leu Gly Gly Leu Pro 
65                  70                  75                  80  


Arg Leu Asn Gly Leu Ala Ser Ser Ala Gly Val Tyr Phe Gly Pro Ala 
                85                  90                  95      


Ala Ala Val Ala Arg Gly Tyr Pro Lys Pro Leu Ala Glu Leu Pro Gly 
            100                 105                 110         


Arg Pro Pro Ile Phe Trp Pro Gly Val Val Gln Gly Ala Pro Trp Arg 
        115                 120                 125             


Asp Pro Arg Leu Ala Gly Pro Ala Pro Ala Gly Gly Val Leu Asp Lys 
    130                 135                 140                 


Asp Gly Lys Lys Lys His Ser Arg Pro Thr Phe Ser Gly Gln Gln Ile 
145                 150                 155                 160 


Phe Ala Leu Glu Lys Thr Phe Glu Gln Thr Lys Tyr Leu Ala Gly Pro 
                165                 170                 175     


Glu Arg Ala Arg Leu Ala Tyr Ser Leu Gly Met Thr Glu Ser Gln Val 
            180                 185                 190         


Lys Val Trp Phe Gln Asn Arg Arg Thr Lys Trp Arg Lys Arg His Ala 
        195                 200                 205             


Val Glu Met Ala Ser Ala Lys Lys Lys Gln Asp Ser Asp Ala Glu Lys 
    210                 215                 220                 


Leu Lys Val Gly Gly Ser Asp Ala Glu Asp Asp Asp Glu Tyr Asn Arg 
225                 230                 235                 240 


Pro Leu Asp Pro Asn Ser Asp Asp Glu Lys Ile Thr Arg Leu Leu Lys 
                245                 250                 255     


Lys His Lys Pro Ser Asn Leu Ala Leu Val Ser Pro Cys Gly Gly Gly 
            260                 265                 270         


Ala Gly Asp Ala Leu 
        275         


<210>  9
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Ser Asp Ala Ser Leu Val Ser Ser Arg Pro Ser Ser Pro Glu 
1               5                   10                  15      


Pro Asp Asp Leu Phe Leu Pro Ala Arg Ser Lys Gly Ser Ser Gly Ser 
            20                  25                  30          


Ala Phe Thr Gly Gly Thr Val Ser Ser Ser Thr Pro Ser Asp Cys Pro 
        35                  40                  45              


Pro Glu Leu Ser Ala Glu Leu Arg Gly Ala Met Gly Ser Ala Gly Ala 
    50                  55                  60                  


His Pro Gly Asp Lys Leu Gly Gly Ser Gly Phe Lys Ser Ser Ser Ser 
65                  70                  75                  80  


Ser Thr Ser Ser Ser Thr Ser Ser Ala Ala Ala Ser Ser Thr Lys Lys 
                85                  90                  95      


Asp Lys Lys Gln Met Thr Glu Pro Glu Leu Gln Gln Leu Arg Leu Lys 
            100                 105                 110         


Ile Asn Ser Arg Glu Arg Lys Arg Met His Asp Leu Asn Ile Ala Met 
        115                 120                 125             


Asp Gly Leu Arg Glu Val Met Pro Tyr Ala His Gly Pro Ser Val Arg 
    130                 135                 140                 


Lys Leu Ser Lys Ile Ala Thr Leu Leu Leu Ala Arg Asn Tyr Ile Leu 
145                 150                 155                 160 


Met Leu Thr Asn Ser Leu Glu Glu Met Lys Arg Leu Val Ser Glu Ile 
                165                 170                 175     


Tyr Gly Gly His His Ala Gly Phe His Pro Ser Ala Cys Gly Gly Leu 
            180                 185                 190         


Ala His Ser Ala Pro Leu Pro Ala Ala Thr Ala His Pro Ala Ala Ala 
        195                 200                 205             


Ala His Ala Ala His His Pro Ala Val His His Pro Ile Leu Pro Pro 
    210                 215                 220                 


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Ser Ser 
225                 230                 235                 240 


Ala Ser Leu Pro Gly Ser Gly Leu Pro Ser Val Gly Ser Ile Arg Pro 
                245                 250                 255     


Pro His Gly Leu Leu Lys Ser Pro Ser Ala Ala Ala Ala Ala Pro Leu 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Ser Gly Ala Ser Gly Gly Phe Gln His Trp 
        275                 280                 285             


Gly Gly Met Pro Cys Pro Cys Ser Met Cys Gln Val Pro Pro Pro His 
    290                 295                 300                 


His His Val Ser Ala Met Gly Ala Gly Ser Leu Pro Arg Leu Thr Ser 
305                 310                 315                 320 


Asp Ala Lys 
            


<210>  10
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


