                         SEQUENCE LISTING

<110>  THE CLEVELAND CLINIC FOUNDATION
 
<120>  ANTITUMOR TET2 MODULATING COMPOUNDS

<130>  CCF-027130WO ORD

<150>  62/591,884
<151>  2017-11-29

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Asp Asn Leu Gln Ser Leu Ala Thr Arg Leu Ala Pro Ile Tyr Lys 
1               5                   10                  15      


Gln Tyr Ala Pro Val Ala Tyr Gln Asn Gln Val Glu Tyr Glu Asn Val 
            20                  25                  30          


Ala Arg Glu Cys Arg Leu Gly Ser Lys Glu Gly Arg Pro Phe Ser Gly 
        35                  40                  45              


Val Thr Ala Cys Leu Asp Phe Cys Ala His Pro His Arg Asp Ile His 
    50                  55                  60                  


Asn Met Asn Asn Gly Ser Thr Val Val Cys Thr Leu Thr Arg Glu Asp 
65                  70                  75                  80  


Asn Arg Ser Leu Gly Val Ile Pro Gln Asp Glu Gln Leu His Val Leu 
                85                  90                  95      


Pro Leu Tyr Lys Leu Ser Asp Thr Asp Glu Phe Gly Ser Lys Glu Gly 
            100                 105                 110         


Met Glu Ala Lys Ile Lys Ser Gly Pro Asn His Gln Pro Ser Phe Leu 
        115                 120                 125             


Thr Ser Pro Gln Asp Leu Ala Ser Ser Pro Met Glu Glu Asp Glu Gln 
    130                 135                 140                 


His Ser Glu Ala Asp Glu Pro Pro Ser Asp Glu Pro Leu Ser Asp Asp 
145                 150                 155                 160 


Pro Leu Ser Pro Ala Glu Glu Lys Leu Pro His Ile Asp Glu Tyr Trp 
                165                 170                 175     


Ser Asp Ser Glu His Ile Phe Leu Asp Ala Asn Ile Gly Gly Val Ala 
            180                 185                 190         


Ile Ala Pro Ala His Gly Ser Val Leu Ile Glu Cys Ala Arg Arg Glu 
        195                 200                 205             


Leu His Ala Thr Thr Pro Val Glu His Pro Asn Arg Asn His Pro Thr 
    210                 215                 220                 


Arg Leu Ser Leu Val Phe Tyr Gln His Lys Asn Leu Asn Lys Pro Gln 
225                 230                 235                 240 


His Gly Phe Glu Leu Asn Lys Ile Lys Phe Glu Ala Lys Glu Ala Lys 
                245                 250                 255     


Asn Lys Lys Met Lys Ala Ser Glu Gln Lys Asp Gln Ala Ala Asn Glu 
            260                 265                 270         


Gly Pro Glu Gln Ser Ser Glu Val Asn Glu Leu Asn Gln Ile Pro Ser 
        275                 280                 285             


His Lys Ala Leu Thr Leu Thr His Asp Asn Val Val Thr Val Ser Pro 
    290                 295                 300                 


Tyr Ala Leu Thr His Val Ala Gly Pro Tyr Asn His Trp Val 
305                 310                 315             


<210>  2
<211>  368
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Ser His Leu Gln Asn Leu Ser Thr Leu Met Ala Pro Thr Tyr Lys 
1               5                   10                  15      


Lys Leu Ala Pro Asp Ala Tyr Asn Asn Gln Ile Glu Tyr Glu His Arg 
            20                  25                  30          


Ala Pro Glu Cys Arg Leu Gly Leu Lys Glu Gly Arg Pro Phe Ser Gly 
        35                  40                  45              


Val Thr Ala Cys Leu Asp Phe Cys Ala His Ala His Arg Asp Leu His 
    50                  55                  60                  


Asn Met Gln Asn Gly Ser Thr Leu Val Cys Thr Leu Thr Arg Glu Asp 
65                  70                  75                  80  


Asn Arg Glu Phe Gly Gly Lys Pro Glu Asp Glu Gln Leu His Val Leu 
                85                  90                  95      


Pro Leu Tyr Lys Val Ser Asp Val Asp Glu Phe Gly Ser Val Glu Ala 
            100                 105                 110         


Gln Glu Glu Lys Lys Arg Ser Gly Glu His His Ser Pro Ser His Ile 
        115                 120                 125             


Ile His Asn Val Ser Ala Ala Pro Gly Met Phe Asn Ser Ser Leu His 
    130                 135                 140                 


Ala Leu His Leu Gln Asn Lys Glu Asn Asp Met Leu Ser His Thr Ala 
145                 150                 155                 160 


Asn Gly Leu Ser Lys Met Leu Pro Ala Leu Asn His Asp Arg Thr Ala 
                165                 170                 175     


Cys Val Gln Gly Gly Leu His Lys Leu Ser Asp Ala Asn Gly Gln Glu 
            180                 185                 190         


Lys Gln Pro Leu Ala Leu Val Gln Gly Val Ala Ser Gly Ala Glu Asp 
        195                 200                 205             


Asn Asp Glu Val Trp Ser Asp Ser Glu Gln Ser Phe Leu Asp Pro Asp 
    210                 215                 220                 


Ile Gly Gly Val Ala Val Ala Pro Thr His Gly Ser Ile Leu Ile Glu 
225                 230                 235                 240 


Cys Ala Lys Arg Glu Leu His Ala Thr Thr Pro Leu Lys Asn Pro Asn 
                245                 250                 255     


Arg Asn His Pro Thr Arg Ile Ser Leu Val Phe Tyr Gln His Lys Ser 
            260                 265                 270         


Met Asn Glu Pro Lys His Gly Leu Ala Leu Trp Glu Ala Lys Met Ala 
        275                 280                 285             


Glu Lys Ala Arg Glu Lys Glu Glu Glu Cys Glu Lys Tyr Gly Pro Asp 
    290                 295                 300                 


Tyr Val Pro Gln Lys Ser His Gly Lys Lys Val Lys Arg Glu Pro Ala 
305                 310                 315                 320 


Glu Pro His Glu Thr Ser Glu Pro Thr Tyr Leu Arg Phe Ile Lys Ser 
                325                 330                 335     


Leu Ala Glu Arg Thr Met Ser Val Thr Thr Asp Ser Thr Val Thr Thr 
            340                 345                 350         


Ser Pro Tyr Ala Phe Thr Arg Val Thr Gly Pro Tyr Asn Arg Tyr Ile 
        355                 360                 365             


<210>  3
<211>  392
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Lys Ser Phe Gln Asp Leu Ala Thr Glu Val Ala Pro Leu Tyr Lys 
1               5                   10                  15      


Arg Leu Ala Pro Gln Ala Tyr Gln Asn Gln Val Thr Asn Glu Glu Ile 
            20                  25                  30          


Ala Ile Asp Cys Arg Leu Gly Leu Lys Glu Gly Arg Pro Phe Ala Gly 
        35                  40                  45              


Val Thr Ala Cys Met Asp Phe Cys Ala His Ala His Lys Asp Gln His 
    50                  55                  60                  


Asn Leu Tyr Asn Gly Cys Thr Val Val Cys Thr Leu Thr Lys Glu Asp 
65                  70                  75                  80  


Asn Arg Cys Val Gly Lys Ile Pro Glu Asp Glu Gln Leu His Val Leu 
                85                  90                  95      


Pro Leu Tyr Lys Met Ala Asn Thr Asp Glu Phe Gly Ser Glu Glu Asn 
            100                 105                 110         


Gln Asn Ala Lys Val Gly Ser Gly Ala Leu Ala Gly Pro Ser Leu Thr 
        115                 120                 125             


Glu Lys Pro Trp Ala Leu Gly Ala Gly Asp Phe Asn Ser Ala Leu Lys 
    130                 135                 140                 


Gly Ser Pro Gly Phe Gln Asp Lys Leu Trp Asn Pro Met Lys Gly Glu 
145                 150                 155                 160 


Glu Gly Arg Ile Pro Ala Ala Gly Ala Ser Gln Leu Asp Arg Ala Trp 
                165                 170                 175     


Gln Ser Phe Gly Leu Pro Leu Gly Ser Ser Glu Lys Leu Phe Gly Ala 
            180                 185                 190         


Leu Lys Ser Glu Glu Lys Leu Trp Asp Pro Phe Ser Leu Glu Glu Gly 
        195                 200                 205             


Pro Ala Glu Glu Pro Pro Ser Lys Gly Ala Val Lys Glu Glu Lys Gly 
    210                 215                 220                 


Gly Gly Gly Ala Glu Glu Glu Glu Glu Glu Leu Trp Ser Asp Ser Glu 
225                 230                 235                 240 


His Asn Phe Leu Asp Glu Asn Ile Gly Gly Val Ala Val Ala Pro Ala 
                245                 250                 255     


His Gly Ser Ile Leu Ile Glu Cys Ala Arg Arg Glu Leu His Ala Thr 
            260                 265                 270         


Thr Pro Leu Lys Lys Pro Asn Arg Cys His Pro Thr Arg Ile Ser Leu 
        275                 280                 285             


Val Phe Tyr Gln His Lys Asn Leu Asn Gln Pro Asn His Gly Leu Ala 
    290                 295                 300                 


Leu Trp Glu Ala Lys Met Lys Gln Leu Ala Glu Arg Ala Arg Ala Arg 
305                 310                 315                 320 


Gln Glu Glu Ala Ala Arg Leu Gly Leu Gly Gln Gln Glu Ala Lys Leu 
                325                 330                 335     


Tyr Gly Lys Lys Arg Lys Trp Gly Gly Thr Val Val Ala Glu Pro Gln 
            340                 345                 350         


Gln Lys Glu Lys Lys Gly Val Val Pro Thr Arg Gln Ala Leu Ala Val 
        355                 360                 365             


Pro Thr Asp Ser Ala Val Thr Val Ser Ser Tyr Ala Tyr Thr Lys Val 
    370                 375                 380                 


Thr Gly Pro Tyr Ser Arg Trp Ile 
385                 390         


