                         SEQUENCE LISTING

<110>  Seattle Genetics, Inc.
 
<120>  CD47 ANTIBODIES AND USES THEREOF FOR TREATING CANCER

<130>  01218-0002-00PCT

<150>  US 62/593,712
<151>  2017-12-01

<160>  95    

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  unknown

<220>
<223>  Murine

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Ile Asp Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  2
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain variable region

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  3
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain variable region

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  4
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain variable region

<400>  4

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  5
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain variable region

<400>  5

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  6
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain variable region

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Thr Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  7
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain variable region

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  8
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized heavy chain variable region

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ala Thr Ile Thr Ser Gly Gly Thr Tyr Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Ala Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  9
<211>  108
<212>  PRT
<213>  unknown

<220>
<223>  Murine

<400>  9

Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Pro 
65                  70                  75                  80  


Glu Asp Val Gly Val Tyr Tyr Cys Gln Asn Gly His Gly Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  10
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain variable region

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Gln Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Asn Gly His Gly Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  11
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain variable region

<400>  11

Glu Ile Val Met Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Val Tyr Tyr Cys Gln Asn Gly His Gly Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  12
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain variable region

<400>  12

Glu Ile Val Met Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Gly His Gly Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  13
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain variable region

<400>  13

Glu Ile Val Met Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Gly His Gly Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  14
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain variable region

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Arg Ala Ser Gln Thr Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Asn Gly His Gly Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  15
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized light chain variable region

<400>  15

Glu Ile Val Met Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Leu Thr Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Phe Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Ala His Gly Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  16

Gly Tyr Gly Met Ser 
1               5   


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  17

Thr Ile Thr Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  18

Ser Leu Ala Gly Asn Ala Met Asp Tyr 
1               5                   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  19

Ser Tyr Ala Met Ser 
1               5   


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  20

Thr Ile Thr Ser Gly Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  21

Ser Tyr Gly Met Asn 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  22

Thr Ile Thr Ser Gly Gly Thr Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  23

Ser Tyr Gly Met His 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  24

Thr Ile Thr Ser Gly Gly Thr Tyr Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  25

Gly Phe Thr Phe Ser Gly Tyr Gly 
1               5               


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  26

Ile Thr Ser Gly Gly Thr Tyr Thr 
1               5               


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  27

Ala Arg Ser Leu Ala Gly Asn Ala Met Asp Tyr 
1               5                   10      


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  28

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  29

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain CDR sequence

<400>  30

Ile Thr Ser Gly Gly Thr Tyr Ile 
1               5               


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR sequence

<400>  31

Arg Ala Ser Gln Thr Ile Ser Asp Tyr Leu His 
1               5                   10      


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR sequence

<400>  32

Phe Ala Ser Gln Ser Ile Ser 
1               5           


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR sequence

<400>  33

Gln Asn Gly His Gly Phe Pro Arg Thr 
1               5                   


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR sequence

<400>  34

Arg Ala Ser Gln Thr Ile Ser Asn Tyr Leu Ala 
1               5                   10      


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR sequence

<400>  35

Phe Ala Ser Thr Leu Gln Ser 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR sequence

<400>  36

Gln Asn Ala His Gly Phe Pro Arg Thr 
1               5                   


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR sequence

<400>  37

Gln Thr Ile Ser Asp Tyr 
1               5       


<210>  38
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR sequence

<400>  38

Phe Ala Ser 
1           


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR sequence

<400>  39

Gln Asn Gly His Gly Phe Pro Arg Thr 
1               5                   


<210>  40
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR sequence

<400>  40

Gln Thr Ile Ser Asn Tyr 
1               5       


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain CDR sequence

<400>  41

Gln Asn Ala His Gly Phe Pro Arg Thr 
1               5                   


<210>  42
<211>  488
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masked heavy chain

<400>  42

Gln Gly Ala Ser Thr Ser Val Asp Glu Leu Gln Ala Glu Val Asp Gln 
1               5                   10                  15      


Leu Glu Asp Glu Asn Tyr Ala Leu Lys Thr Lys Val Ala Gln Leu Arg 
            20                  25                  30          


Lys Lys Val Glu Lys Leu Gly Ser Ile Pro Val Ser Leu Arg Ser Gly 
        35                  40                  45              


Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    50                  55                  60                  


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr 
65                  70                  75                  80  


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Arg Leu Glu Trp Val 
                85                  90                  95      


Ala Thr Ile Thr Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro Asp Ser Val 
            100                 105                 110         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
        115                 120                 125             


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Phe Cys 
    130                 135                 140                 


Ala Arg Ser Leu Ala Gly Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
145                 150                 155                 160 


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
                165                 170                 175     


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
            180                 185                 190         


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
        195                 200                 205             


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
    210                 215                 220                 


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
225                 230                 235                 240 


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
                245                 250                 255     


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
            260                 265                 270         


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys 
                485             


<210>  43
<211>  262
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masked light chain

<400>  43

Gln Gly Ala Ser Thr Thr Val Ala Gln Leu Glu Glu Lys Val Lys Thr 
1               5                   10                  15      


Leu Arg Ala Glu Asn Tyr Glu Leu Lys Ser Glu Val Gln Arg Leu Glu 
            20                  25                  30          


Glu Gln Val Ala Gln Leu Gly Ser Ile Pro Val Ser Leu Arg Ser Gly 
        35                  40                  45              


Glu Ile Val Met Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
    50                  55                  60                  


Glu Lys Val Thr Leu Thr Cys Arg Ala Ser Gln Thr Ile Ser Asp Tyr 
65                  70                  75                  80  


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
                85                  90                  95      


Lys Phe Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
            100                 105                 110         


Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
        115                 120                 125             


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Asn Gly His Gly Phe Pro Arg 
    130                 135                 140                 


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
145                 150                 155                 160 


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
                165                 170                 175     


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
            180                 185                 190         


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
        195                 200                 205             


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
    210                 215                 220                 


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
225                 230                 235                 240 


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
                245                 250                 255     


Phe Asn Arg Gly Glu Cys 
            260         


<210>  44
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  44

Gly Ala Ser Thr Ser Val Asp Glu Leu Gln Ala Glu Val Asp Gln Leu 
1               5                   10                  15      


Gln Asp Glu Asn Tyr Ala Leu Lys Thr Lys Val Ala Gln Leu Arg Lys 
            20                  25                  30          


Lys Val Glu Lys Leu Ser Glu Gly Gly Gly Gly Gly Pro Leu Gly Val 
        35                  40                  45              


Arg Gly Gly Gly Gly Ser 
    50                  


<210>  45
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  45

Gly Ala Ser Thr Thr Val Ala Gln Leu Arg Glu Arg Val Lys Thr Leu 
1               5                   10                  15      


Arg Ala Gln Asn Tyr Glu Leu Glu Ser Glu Val Gln Arg Leu Arg Glu 
            20                  25                  30          


Gln Val Ala Gln Leu Ala Ser Gly Gly Gly Gly Gly Pro Leu Gly Val 
        35                  40                  45              


Arg Gly Gly Gly Gly Ser 
    50                  


<210>  46
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  46

Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala Leu Glu 
1               5                   10                  15      


Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg Ala Arg Asn Arg 
            20                  25                  30          


Val Ser Gln Tyr Arg Thr Arg Tyr Gly Gly Gly Gly Gly Pro Leu Gly 
        35                  40                  45              


Val Arg Gly Gly Gly Gly Ser 
    50                  55  


<210>  47
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  47

Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn Thr Ala Leu Arg 
1               5                   10                  15      


Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Glu 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr Gly Gly Gly Gly Gly Pro Leu Gly 
        35                  40                  45              


Val Arg Gly Gly Gly Gly Ser 
    50                  55  


<210>  48
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  48

Leu Glu Ile Arg Ala Ala Phe Leu Arg Arg Arg Asn Thr Ala Leu Arg 
1               5                   10                  15      


Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg Leu Arg Asn Ile 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr Gly Gly Gly Gly Gly Gly Pro Leu 
        35                  40                  45              


Gly Val Arg Gly Gly Gly Gly Ser 
    50                  55      


<210>  49
<211>  56
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  49

Leu Glu Ile Glu Ala Ala Phe Leu Glu Gln Glu Asn Thr Ala Leu Glu 
1               5                   10                  15      


Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu Glu Asn Ile 
            20                  25                  30          


Val Ser Gln Tyr Glu Thr Arg Tyr Gly Gly Gly Gly Gly Gly Pro Leu 
        35                  40                  45              


Gly Val Arg Gly Gly Gly Gly Ser 
    50                  55      


<210>  50
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  50

Gly Ala Ser Thr Ser Val Asp Glu Leu Gln Ala Glu Val Asp Gln Leu 
1               5                   10                  15      


Glu Asp Glu Asn Tyr Ala Leu Lys Thr Lys Val Ala Gln Leu Arg Lys 
            20                  25                  30          


Lys Val Glu Lys Leu Gly Ser Ile Pro Val Ser Leu Arg Ser Gly 
        35                  40                  45          


<210>  51
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  51

Gly Ala Ser Thr Thr Val Ala Gln Leu Glu Glu Lys Val Lys Thr Leu 
1               5                   10                  15      


Arg Ala Glu Asn Tyr Glu Leu Lys Ser Glu Val Gln Arg Leu Glu Glu 
            20                  25                  30          


Gln Val Ala Gln Leu Gly Ser Ile Pro Val Ser Leu Arg Ser Gly 
        35                  40                  45          


<210>  52
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  52

Gly Ala Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp 
1               5                   10                  15      


Lys Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys 
            20                  25                  30          


Glu Lys Leu Glu Phe Ile Leu Ala Ala His Gly Gly Gly Gly Gly Pro 
        35                  40                  45              


Leu Gly Val Arg Gly Gly Gly Gly Ser 
    50                  55          


<210>  53
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  53

Gly Ala Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ala 
1               5                   10                  15      


Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg Glu Gln Val 
            20                  25                  30          


Ala Gln Leu Lys Gln Lys Val Met Asn Tyr Gly Gly Gly Gly Gly Pro 
        35                  40                  45              


Leu Gly Val Arg Gly Gly Gly Gly Ser 
    50                  55          


<210>  54
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  54

Gly Lys Ile Ala Ala Leu Lys Gln Lys Ile Ala Ala Leu Lys Tyr Lys 
1               5                   10                  15      


Asn Ala Ala Leu Lys Lys Lys Ile Ala Ala Leu Lys Gln Gly Gly Gly 
            20                  25                  30          


Gly Gly Pro Leu Gly Val Arg Gly Gly Gly Gly Ser 
        35                  40                  


<210>  55
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  55

Gly Glu Ile Ala Ala Leu Glu Gln Glu Ile Ala Ala Leu Glu Lys Glu 
1               5                   10                  15      


Asn Ala Ala Leu Glu Trp Glu Ile Ala Ala Leu Glu Gln Gly Gly Gly 
            20                  25                  30          


Gly Gly Pro Leu Gly Val Arg Gly Gly Gly Gly Ser 
        35                  40                  


<210>  56

<400>  56
000

<210>  57
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease cleavage sequence

<400>  57

Gly Pro Leu Gly Val Arg 
1               5       


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Protease cleavage sequence

<400>  58

Ile Pro Val Ser Leu Arg Ser Gly 
1               5               


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary linker

<400>  59

Gly Ser Gly Gly Ser 
1               5   


<210>  60
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary linker

<400>  60

Gly Gly Gly Ser 
1               


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary linker

<400>  61

Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser 
1               5                   10          


<210>  62
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary linker

<400>  62

Gly Gly Ala Ala 
1               


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary linker

<400>  63

Gly Gly Gly Gly Ser 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary linker

<400>  64

Leu Ala Ala Ala Ala 
1               5   


<210>  65
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary linker

<400>  65

Gly Gly Ser Gly 
1               


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary linker

<400>  66

Gly Gly Ser Gly Gly 
1               5   


<210>  67
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary linker

<400>  67

Gly Ser Gly Ser Gly 
1               5   


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary linker

<400>  68

Gly Ser Gly Gly Gly 
1               5   


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary linker

<400>  69

Gly Gly Gly Ser Gly 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary linker

<400>  70

Gly Ser Ser Ser Gly 
1               5   


<210>  71
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protease site


<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  71

Pro Leu Gly Xaa Xaa Xaa 
1               5       


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protease site

<400>  72

Pro Leu Gly Val Arg 
1               5   


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protease site

<400>  73

Ile Pro Val Ser Leu Arg Ser Gly 
1               5               


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  exemplary protease site

<400>  74

Leu Ser Gly Arg Ser Asp Asn Tyr 
1               5               


<210>  75
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  75

Glu Ala Cys Gly Ala Ser Thr Ser Val Asp Glu Leu Gln Ala Glu Val 
1               5                   10                  15      


Asp Gln Leu Gln Asp Glu Asn Tyr Ala Leu Lys Thr Lys Val Ala Gln 
            20                  25                  30          


Leu Arg Lys Lys Val Glu Lys Leu Ser Glu Gly Gly Gly Gly Gly Pro 
        35                  40                  45              


Leu Gly Val Arg Gly Gly Gly Gly Ser 
    50                  55          


<210>  76
<211>  57
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  76

Glu Ala Cys Gly Ala Ser Thr Thr Val Ala Gln Leu Arg Glu Arg Val 
1               5                   10                  15      


Lys Thr Leu Arg Ala Gln Asn Tyr Glu Leu Glu Ser Glu Val Gln Arg 
            20                  25                  30          


Leu Arg Glu Gln Val Ala Gln Leu Ala Ser Gly Gly Gly Gly Gly Pro 
        35                  40                  45              


Leu Gly Val Arg Gly Gly Gly Gly Ser 
    50                  55          


<210>  77
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  77

Glu Ala Cys Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn Thr 
1               5                   10                  15      


Ala Leu Glu Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg Ala 
            20                  25                  30          


Arg Asn Arg Val Ser Gln Tyr Arg Thr Arg Tyr Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Leu Gly Val Arg Gly Gly Gly Gly Ser 
    50                  55              


<210>  78
<211>  58
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  78

Glu Ala Cys Leu Glu Ile Arg Ala Ala Phe Leu Arg Gln Arg Asn Thr 
1               5                   10                  15      


Ala Leu Arg Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu 
            20                  25                  30          


Glu Asn Glu Val Ser Gln Tyr Glu Thr Arg Tyr Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Leu Gly Val Arg Gly Gly Gly Gly Ser 
    50                  55              


<210>  79
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  79

Glu Ala Cys Leu Glu Ile Arg Ala Ala Phe Leu Arg Arg Arg Asn Thr 
1               5                   10                  15      


Ala Leu Arg Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg Leu 
            20                  25                  30          


Arg Asn Ile Val Ser Gln Tyr Glu Thr Arg Tyr Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Pro Leu Gly Val Arg Gly Gly Gly Gly Ser 
    50                  55                  


<210>  80
<211>  59
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  80

Glu Ala Cys Leu Glu Ile Glu Ala Ala Phe Leu Glu Gln Glu Asn Thr 
1               5                   10                  15      


Ala Leu Glu Thr Glu Val Ala Glu Leu Glu Gln Glu Val Gln Arg Leu 
            20                  25                  30          


Glu Asn Ile Val Ser Gln Tyr Glu Thr Arg Tyr Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Pro Leu Gly Val Arg Gly Gly Gly Gly Ser 
    50                  55                  


<210>  81
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  81

Glu Ala Cys Gly Ala Ser Thr Ser Val Asp Glu Leu Gln Ala Glu Val 
1               5                   10                  15      


Asp Gln Leu Glu Asp Glu Asn Tyr Ala Leu Lys Thr Lys Val Ala Gln 
            20                  25                  30          


Leu Arg Lys Lys Val Glu Lys Leu Gly Ser Ile Pro Val Ser Leu Arg 
        35                  40                  45              


Ser Gly 
    50  


<210>  82
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  82

Glu Ala Cys Gly Ala Ser Thr Thr Val Ala Gln Leu Glu Glu Lys Val 
1               5                   10                  15      


Lys Thr Leu Arg Ala Glu Asn Tyr Glu Leu Lys Ser Glu Val Gln Arg 
            20                  25                  30          


Leu Glu Glu Gln Val Ala Gln Leu Gly Ser Ile Pro Val Ser Leu Arg 
        35                  40                  45              


Ser Gly 
    50  


<210>  83
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  83

Glu Ala Cys Gly Ala Leu Thr Asp Thr Leu Gln Ala Glu Thr Asp Gln 
1               5                   10                  15      


Leu Glu Asp Lys Lys Ser Ala Leu Gln Thr Glu Ile Ala Asn Leu Leu 
            20                  25                  30          


Lys Glu Lys Glu Lys Leu Glu Phe Ile Leu Ala Ala His Gly Gly Gly 
        35                  40                  45              


Gly Gly Pro Leu Gly Val Arg Gly Gly Gly Gly Ser 
    50                  55                  60  


<210>  84
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  84

Glu Ala Cys Gly Ala Arg Ile Ala Arg Leu Glu Glu Lys Val Lys Thr 
1               5                   10                  15      


Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn Met Leu Arg 
            20                  25                  30          


Glu Gln Val Ala Gln Leu Lys Gln Lys Val Met Asn Tyr Gly Gly Gly 
        35                  40                  45              


Gly Gly Pro Leu Gly Val Arg Gly Gly Gly Gly Ser 
    50                  55                  60  


<210>  85
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  85

Glu Ala Cys Gly Lys Ile Ala Ala Leu Lys Gln Lys Ile Ala Ala Leu 
1               5                   10                  15      


Lys Tyr Lys Asn Ala Ala Leu Lys Lys Lys Ile Ala Ala Leu Lys Gln 
            20                  25                  30          


Gly Gly Gly Gly Gly Pro Leu Gly Val Arg Gly Gly Gly Gly Ser 
        35                  40                  45          


<210>  86
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  86

Glu Ala Cys Gly Glu Ile Ala Ala Leu Glu Gln Glu Ile Ala Ala Leu 
1               5                   10                  15      


Glu Lys Glu Asn Ala Ala Leu Glu Trp Glu Ile Ala Ala Leu Glu Gln 
            20                  25                  30          


Gly Gly Gly Gly Gly Pro Leu Gly Val Arg Gly Gly Gly Gly Ser 
        35                  40                  45          


<210>  87

<400>  87
000

<210>  88
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  88

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  89
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  89

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  90
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  90

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


<210>  91
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  91

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  92
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  92

Glu Ile Val Leu Thr Gln Ser Pro Asp Phe Gln Ser Val Thr Pro Lys 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Ser 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Pro Asp Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Ala 
65                  70                  75                  80  


Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Ser Ser Ser Leu Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  93
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  93

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105         


<210>  94
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  94

Gln Gly Ala Ser Thr Ser Val Asp Glu Leu Gln Ala Glu Val Asp Gln 
1               5                   10                  15      


Leu Glu Asp Glu Asn Tyr Ala Leu Lys Thr Lys Val Ala Gln Leu Arg 
            20                  25                  30          


Lys Lys Val Glu Lys Leu Gly Ser 
        35                  40  


<210>  95
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Masking domain sequence

<400>  95

Gln Gly Ala Ser Thr Thr Val Ala Gln Leu Glu Glu Lys Val Lys Thr 
1               5                   10                  15      


Leu Arg Ala Glu Asn Tyr Glu Leu Lys Ser Glu Val Gln Arg Leu Glu 
            20                  25                  30          


Glu Gln Val Ala Gln Leu Gly Ser 
        35                  40  


