                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       TZAHOR, Eldad
       UMANSKY, Kfir Baruch
       HINKEL, Rabea
       KUPATT, Christian
 
<120>  TREATMENT OF AN ISCHEMIC HEART DISEASE

<130>  75814

<150>  US 62/593,942
<151>  2017-12-03

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  4392
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu 
            20                  25                  30          


Ser Leu Pro Glu Asp Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp 
        35                  40                  45              


Thr His Ser Tyr Leu Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile 
    50                  55                  60                  


Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp Phe Gln 
65                  70                  75                  80  


Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg Ser Ile Glu Tyr 
                85                  90                  95      


Ser Pro Gln Leu Glu Asp Ala Gly Ser Arg Glu Phe Arg Glu Val Ser 
            100                 105                 110         


Glu Ala Val Val Asp Thr Leu Glu Ser Glu Tyr Leu Lys Ile Pro Gly 
        115                 120                 125             


Asp Gln Val Val Ser Val Val Phe Ile Lys Glu Leu Asp Gly Trp Val 
    130                 135                 140                 


Phe Val Glu Leu Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln 
145                 150                 155                 160 


Ile Gln Glu Met Leu Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser 
                165                 170                 175     


Tyr Val Thr Ser Pro Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val 
            180                 185                 190         


Pro Gln Phe Pro Arg Ala Cys Thr Glu Ala Glu Phe Ala Cys His Ser 
        195                 200                 205             


Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp Arg Arg Pro Asp 
    210                 215                 220                 


Cys Arg Asp Met Ser Asp Glu Leu Asn Cys Glu Glu Pro Val Leu Gly 
225                 230                 235                 240 


Ile Ser Pro Thr Phe Ser Leu Leu Val Glu Thr Thr Ser Leu Pro Pro 
                245                 250                 255     


Arg Pro Glu Thr Thr Ile Met Arg Gln Pro Pro Val Thr His Ala Pro 
            260                 265                 270         


Gln Pro Leu Leu Pro Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln 
        275                 280                 285             


Glu Ala Ala Cys Arg Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys 
    290                 295                 300                 


Asp Gly Gln Glu Asp Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly 
305                 310                 315                 320 


Pro Pro Pro Pro Cys Glu Pro Asn Glu Phe Pro Cys Gly Asn Gly His 
                325                 330                 335     


Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp Phe Asp Cys Glu Asp 
            340                 345                 350         


Arg Thr Asp Glu Ala Asn Cys Pro Thr Lys Arg Pro Glu Glu Val Cys 
        355                 360                 365             


Gly Pro Thr Gln Phe Arg Cys Val Ser Thr Asn Met Cys Ile Pro Ala 
    370                 375                 380                 


Ser Phe His Cys Asp Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu 
385                 390                 395                 400 


Phe Gly Cys Met Pro Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile 
                405                 410                 415     


Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly 
            420                 425                 430         


Val Pro Thr Pro Ile Ile Asn Trp Arg Leu Asn Trp Gly His Ile Pro 
        435                 440                 445             


Ser His Pro Arg Val Thr Val Thr Ser Glu Gly Gly Arg Gly Thr Leu 
    450                 455                 460                 


Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly Ala Tyr Thr Cys Glu 
465                 470                 475                 480 


Ala Met Asn Ala Arg Gly Met Val Phe Gly Ile Pro Asp Gly Val Leu 
                485                 490                 495     


Glu Leu Val Pro Gln Arg Ala Gly Pro Cys Pro Asp Gly His Phe Tyr 
            500                 505                 510         


Leu Glu His Ser Ala Ala Cys Leu Pro Cys Phe Cys Phe Gly Ile Thr 
        515                 520                 525             


Ser Val Cys Gln Ser Thr Arg Arg Phe Arg Asp Gln Ile Arg Leu Arg 
    530                 535                 540                 


Phe Asp Gln Pro Asp Asp Phe Lys Gly Val Asn Val Thr Met Pro Ala 
545                 550                 555                 560 


Gln Pro Gly Thr Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp Pro 
                565                 570                 575     


Ser Leu His Glu Phe Gln Leu Val Asp Leu Ser Arg Arg Phe Leu Val 
            580                 585                 590         


His Asp Ser Phe Trp Ala Leu Pro Glu Gln Phe Leu Gly Asn Lys Val 
        595                 600                 605             


Asp Ser Tyr Gly Gly Ser Leu Arg Tyr Asn Val Arg Tyr Glu Leu Ala 
    610                 615                 620                 


Arg Gly Met Leu Glu Pro Val Gln Arg Pro Asp Val Val Leu Met Gly 
625                 630                 635                 640 


Ala Gly Tyr Arg Leu Leu Ser Arg Gly His Thr Pro Thr Gln Pro Gly 
                645                 650                 655     


Ala Leu Asn Gln Arg Gln Val Gln Phe Ser Glu Glu His Trp Val His 
            660                 665                 670         


Glu Ser Gly Arg Pro Val Gln Arg Ala Glu Leu Leu Gln Val Leu Gln 
        675                 680                 685             


Ser Leu Glu Ala Val Leu Ile Gln Thr Val Tyr Asn Thr Lys Met Ala 
    690                 695                 700                 


Ser Val Gly Leu Ser Asp Ile Ala Met Asp Thr Thr Val Thr His Ala 
705                 710                 715                 720 


Thr Ser His Gly Arg Ala His Ser Val Glu Glu Cys Arg Cys Pro Ile 
                725                 730                 735     


Gly Tyr Ser Gly Leu Ser Cys Glu Ser Cys Asp Ala His Phe Thr Arg 
            740                 745                 750         


Val Pro Gly Gly Pro Tyr Leu Gly Thr Cys Ser Gly Cys Asn Cys Asn 
        755                 760                 765             


Gly His Ala Ser Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn Cys 
    770                 775                 780                 


Gln His Asn Thr Glu Gly Pro Gln Cys Asn Lys Cys Lys Ala Gly Phe 
785                 790                 795                 800 


Phe Gly Asp Ala Met Lys Ala Thr Ala Thr Ser Cys Arg Pro Cys Pro 
                805                 810                 815     


Cys Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys Phe Leu 
            820                 825                 830         


Asp Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala Pro Gly Tyr Thr 
        835                 840                 845             


Gly Arg Arg Cys Glu Ser Cys Ala Pro Gly Tyr Glu Gly Asn Pro Ile 
    850                 855                 860                 


Gln Pro Gly Gly Lys Cys Arg Pro Val Asn Gln Glu Ile Val Arg Cys 
865                 870                 875                 880 


Asp Glu Arg Gly Ser Met Gly Thr Ser Gly Glu Ala Cys Arg Cys Lys 
                885                 890                 895     


Asn Asn Val Val Gly Arg Leu Cys Asn Glu Cys Ala Asp Gly Ser Phe 
            900                 905                 910         


His Leu Ser Thr Arg Asn Pro Asp Gly Cys Leu Lys Cys Phe Cys Met 
        915                 920                 925             


Gly Val Ser Arg His Cys Thr Ser Ser Ser Trp Ser Arg Ala Gln Leu 
    930                 935                 940                 


His Gly Ala Ser Glu Glu Pro Gly His Phe Ser Leu Thr Asn Ala Ala 
945                 950                 955                 960 


Ser Thr His Thr Thr Asn Glu Gly Ile Phe Ser Pro Thr Pro Gly Glu 
                965                 970                 975     


Leu Gly Phe Ser Ser Phe His Arg Leu Leu Ser Gly Pro Tyr Phe Trp 
            980                 985                 990         


Ser Leu Pro Ser Arg Phe Leu Gly  Asp Lys Val Thr Ser  Tyr Gly Gly 
        995                 1000                 1005             


Glu Leu  Arg Phe Thr Val Thr  Gln Arg Ser Gln Pro  Gly Ser Thr 
    1010                 1015                 1020             


Pro Leu  His Gly Gln Pro Leu  Val Val Leu Gln Gly  Asn Asn Ile 
    1025                 1030                 1035             


Ile Leu  Glu His His Val Ala  Gln Glu Pro Ser Pro  Gly Gln Pro 
    1040                 1045                 1050             


Ser Thr  Phe Ile Val Pro Phe  Arg Glu Gln Ala Trp  Gln Arg Pro 
    1055                 1060                 1065             


Asp Gly  Gln Pro Ala Thr Arg  Glu His Leu Leu Met  Ala Leu Ala 
    1070                 1075                 1080             


Gly Ile  Asp Thr Leu Leu Ile  Arg Ala Ser Tyr Ala  Gln Gln Pro 
    1085                 1090                 1095             


Ala Glu  Ser Arg Val Ser Gly  Ile Ser Met Asp Val  Ala Val Pro 
    1100                 1105                 1110             


Glu Glu  Thr Gly Gln Asp Pro  Ala Leu Glu Val Glu  Gln Cys Ser 
    1115                 1120                 1125             


Cys Pro  Pro Gly Tyr Arg Gly  Pro Ser Cys Gln Asp  Cys Asp Thr 
    1130                 1135                 1140             


Gly Tyr  Thr Arg Thr Pro Ser  Gly Leu Tyr Leu Gly  Thr Cys Glu 
    1145                 1150                 1155             


Arg Cys  Ser Cys His Gly His  Ser Glu Ala Cys Glu  Pro Glu Thr 
    1160                 1165                 1170             


Gly Ala  Cys Gln Gly Cys Gln  His His Thr Glu Gly  Pro Arg Cys 
    1175                 1180                 1185             


Glu Gln  Cys Gln Pro Gly Tyr  Tyr Gly Asp Ala Gln  Arg Gly Thr 
    1190                 1195                 1200             


Pro Gln  Asp Cys Gln Leu Cys  Pro Cys Tyr Gly Asp  Pro Ala Ala 
    1205                 1210                 1215             


Gly Gln  Ala Ala His Thr Cys  Phe Leu Asp Thr Asp  Gly His Pro 
    1220                 1225                 1230             


Thr Cys  Asp Ala Cys Ser Pro  Gly His Ser Gly Arg  His Cys Glu 
    1235                 1240                 1245             


Arg Cys  Ala Pro Gly Tyr Tyr  Gly Asn Pro Ser Gln  Gly Gln Pro 
    1250                 1255                 1260             


Cys Gln  Arg Asp Ser Gln Val  Pro Gly Pro Ile Gly  Cys Asn Cys 
    1265                 1270                 1275             


Asp Pro  Gln Gly Ser Val Ser  Ser Gln Cys Asp Ala  Ala Gly Gln 
    1280                 1285                 1290             


Cys Gln  Cys Lys Ala Gln Val  Glu Gly Leu Thr Cys  Ser His Cys 
    1295                 1300                 1305             


Arg Pro  His His Phe His Leu  Ser Ala Ser Asn Pro  Asp Gly Cys 
    1310                 1315                 1320             


Leu Pro  Cys Phe Cys Met Gly  Ile Thr Gln Gln Cys  Ala Ser Ser 
    1325                 1330                 1335             


Ala Tyr  Thr Arg His Leu Ile  Ser Thr His Phe Ala  Pro Gly Asp 
    1340                 1345                 1350             


Phe Gln  Gly Phe Ala Leu Val  Asn Pro Gln Arg Asn  Ser Arg Leu 
    1355                 1360                 1365             


Thr Gly  Glu Phe Thr Val Glu  Pro Val Pro Glu Gly  Ala Gln Leu 
    1370                 1375                 1380             


Ser Phe  Gly Asn Phe Ala Gln  Leu Gly His Glu Ser  Phe Tyr Trp 
    1385                 1390                 1395             


Gln Leu  Pro Glu Thr Tyr Gln  Gly Asp Lys Val Ala  Ala Tyr Gly 
    1400                 1405                 1410             


Gly Lys  Leu Arg Tyr Thr Leu  Ser Tyr Thr Ala Gly  Pro Gln Gly 
    1415                 1420                 1425             


Ser Pro  Leu Ser Asp Pro Asp  Val Gln Ile Thr Gly  Asn Asn Ile 
    1430                 1435                 1440             


Met Leu  Val Ala Ser Gln Pro  Ala Leu Gln Gly Pro  Glu Arg Arg 
    1445                 1450                 1455             


Ser Tyr  Glu Ile Met Phe Arg  Glu Glu Phe Trp Arg  Arg Pro Asp 
    1460                 1465                 1470             


Gly Gln  Pro Ala Thr Arg Glu  His Leu Leu Met Ala  Leu Ala Asp 
    1475                 1480                 1485             


Leu Asp  Glu Leu Leu Ile Arg  Ala Thr Phe Ser Ser  Val Pro Leu 
    1490                 1495                 1500             


Ala Ala  Ser Ile Ser Ala Val  Ser Leu Glu Val Ala  Gln Pro Gly 
    1505                 1510                 1515             


Pro Ser  Asn Arg Pro Arg Ala  Leu Glu Val Glu Glu  Cys Arg Cys 
    1520                 1525                 1530             


Pro Pro  Gly Tyr Ile Gly Leu  Ser Cys Gln Asp Cys  Ala Pro Gly 
    1535                 1540                 1545             


Tyr Thr  Arg Thr Gly Ser Gly  Leu Tyr Leu Gly His  Cys Glu Leu 
    1550                 1555                 1560             


Cys Glu  Cys Asn Gly His Ser  Asp Leu Cys His Pro  Glu Thr Gly 
    1565                 1570                 1575             


Ala Cys  Ser Gln Cys Gln His  Asn Ala Ala Gly Glu  Phe Cys Glu 
    1580                 1585                 1590             


Leu Cys  Ala Pro Gly Tyr Tyr  Gly Asp Ala Thr Ala  Gly Thr Pro 
    1595                 1600                 1605             


Glu Asp  Cys Gln Pro Cys Ala  Cys Pro Leu Thr Asn  Pro Glu Asn 
    1610                 1615                 1620             


Met Phe  Ser Arg Thr Cys Glu  Ser Leu Gly Ala Gly  Gly Tyr Arg 
    1625                 1630                 1635             


Cys Thr  Ala Cys Glu Pro Gly  Tyr Thr Gly Gln Tyr  Cys Glu Gln 
    1640                 1645                 1650             


Cys Gly  Pro Gly Tyr Val Gly  Asn Pro Ser Val Gln  Gly Gly Gln 
    1655                 1660                 1665             


Cys Leu  Pro Glu Thr Asn Gln  Ala Pro Leu Val Val  Glu Val His 
    1670                 1675                 1680             


Pro Ala  Arg Ser Ile Val Pro  Gln Gly Gly Ser His  Ser Leu Arg 
    1685                 1690                 1695             


Cys Gln  Val Ser Gly Ser Pro  Pro His Tyr Phe Tyr  Trp Ser Arg 
    1700                 1705                 1710             


Glu Asp  Gly Arg Pro Val Pro  Ser Gly Thr Gln Gln  Arg His Gln 
    1715                 1720                 1725             


Gly Ser  Glu Leu His Phe Pro  Ser Val Gln Pro Ser  Asp Ala Gly 
    1730                 1735                 1740             


Val Tyr  Ile Cys Thr Cys Arg  Asn Leu His Gln Ser  Asn Thr Ser 
    1745                 1750                 1755             


Arg Ala  Glu Leu Leu Val Thr  Glu Ala Pro Ser Lys  Pro Ile Thr 
    1760                 1765                 1770             


Val Thr  Val Glu Glu Gln Arg  Ser Gln Ser Val Arg  Pro Gly Ala 
    1775                 1780                 1785             


Asp Val  Thr Phe Ile Cys Thr  Ala Lys Ser Lys Ser  Pro Ala Tyr 
    1790                 1795                 1800             


Thr Leu  Val Trp Thr Arg Leu  His Asn Gly Lys Leu  Pro Thr Arg 
    1805                 1810                 1815             


Ala Met  Asp Phe Asn Gly Ile  Leu Thr Ile Arg Asn  Val Gln Leu 
    1820                 1825                 1830             


Ser Asp  Ala Gly Thr Tyr Val  Cys Thr Gly Ser Asn  Met Phe Ala 
    1835                 1840                 1845             


Met Asp  Gln Gly Thr Ala Thr  Leu His Val Gln Ala  Ser Gly Thr 
    1850                 1855                 1860             


Leu Ser  Ala Pro Val Val Ser  Ile His Pro Pro Gln  Leu Thr Val 
    1865                 1870                 1875             


Gln Pro  Gly Gln Leu Ala Glu  Phe Arg Cys Ser Ala  Thr Gly Ser 
    1880                 1885                 1890             


Pro Thr  Pro Thr Leu Glu Trp  Thr Gly Gly Pro Gly  Gly Gln Leu 
    1895                 1900                 1905             


Pro Ala  Lys Ala Gln Ile His  Gly Gly Ile Leu Arg  Leu Pro Ala 
    1910                 1915                 1920             


Val Glu  Pro Thr Asp Gln Ala  Gln Tyr Leu Cys Arg  Ala His Ser 
    1925                 1930                 1935             


Ser Ala  Gly Gln Gln Val Ala  Arg Ala Val Leu His  Val His Gly 
    1940                 1945                 1950             


Gly Gly  Gly Pro Arg Val Gln  Val Ser Pro Glu Arg  Thr Gln Val 
    1955                 1960                 1965             


His Ala  Gly Arg Thr Val Arg  Leu Tyr Cys Arg Ala  Ala Gly Val 
    1970                 1975                 1980             


Pro Ser  Ala Thr Ile Thr Trp  Arg Lys Glu Gly Gly  Ser Leu Pro 
    1985                 1990                 1995             


Pro Gln  Ala Arg Ser Glu Arg  Thr Asp Ile Ala Thr  Leu Leu Ile 
    2000                 2005                 2010             


Pro Ala  Ile Thr Thr Ala Asp  Ala Gly Phe Tyr Leu  Cys Val Ala 
    2015                 2020                 2025             


Thr Ser  Pro Ala Gly Thr Ala  Gln Ala Arg Ile Gln  Val Val Val 
    2030                 2035                 2040             


Leu Ser  Ala Ser Asp Ala Ser  Pro Pro Pro Val Lys  Ile Glu Ser 
    2045                 2050                 2055             


Ser Ser  Pro Ser Val Thr Glu  Gly Gln Thr Leu Asp  Leu Asn Cys 
    2060                 2065                 2070             


Val Val  Ala Gly Ser Ala His  Ala Gln Val Thr Trp  Tyr Arg Arg 
    2075                 2080                 2085             


Gly Gly  Ser Leu Pro Pro His  Thr Gln Val His Gly  Ser Arg Leu 
    2090                 2095                 2100             


Arg Leu  Pro Gln Val Ser Pro  Ala Asp Ser Gly Glu  Tyr Val Cys 
    2105                 2110                 2115             


Arg Val  Glu Asn Gly Ser Gly  Pro Lys Glu Ala Ser  Ile Thr Val 
    2120                 2125                 2130             


Ser Val  Leu His Gly Thr His  Ser Gly Pro Ser Tyr  Thr Pro Val 
    2135                 2140                 2145             


Pro Gly  Ser Thr Arg Pro Ile  Arg Ile Glu Pro Ser  Ser Ser His 
    2150                 2155                 2160             


Val Ala  Glu Gly Gln Thr Leu  Asp Leu Asn Cys Val  Val Pro Gly 
    2165                 2170                 2175             


Gln Ala  His Ala Gln Val Thr  Trp His Lys Arg Gly  Gly Ser Leu 
    2180                 2185                 2190             


Pro Ala  Arg His Gln Thr His  Gly Ser Leu Leu Arg  Leu His Gln 
    2195                 2200                 2205             


Val Thr  Pro Ala Asp Ser Gly  Glu Tyr Val Cys His  Val Val Gly 
    2210                 2215                 2220             


Thr Ser  Gly Pro Leu Glu Ala  Ser Val Leu Val Thr  Ile Glu Ala 
    2225                 2230                 2235             


Ser Val  Ile Pro Gly Pro Ile  Pro Pro Val Arg Ile  Glu Ser Ser 
    2240                 2245                 2250             


Ser Ser  Thr Val Ala Glu Gly  Gln Thr Leu Asp Leu  Ser Cys Val 
    2255                 2260                 2265             


Val Ala  Gly Gln Ala His Ala  Gln Val Thr Trp Tyr  Lys Arg Gly 
    2270                 2275                 2280             


Gly Ser  Leu Pro Ala Arg His  Gln Val Arg Gly Ser  Arg Leu Tyr 
    2285                 2290                 2295             


Ile Phe  Gln Ala Ser Pro Ala  Asp Ala Gly Gln Tyr  Val Cys Arg 
    2300                 2305                 2310             


Ala Ser  Asn Gly Met Glu Ala  Ser Ile Thr Val Thr  Val Thr Gly 
    2315                 2320                 2325             


Thr Gln  Gly Ala Asn Leu Ala  Tyr Pro Ala Gly Ser  Thr Gln Pro 
    2330                 2335                 2340             


Ile Arg  Ile Glu Pro Ser Ser  Ser Gln Val Ala Glu  Gly Gln Thr 
    2345                 2350                 2355             


Leu Asp  Leu Asn Cys Val Val  Pro Gly Gln Ser His  Ala Gln Val 
    2360                 2365                 2370             


Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro Val Arg  His Gln Thr 
    2375                 2380                 2385             


His Gly  Ser Leu Leu Arg Leu  Tyr Gln Ala Ser Pro  Ala Asp Ser 
    2390                 2395                 2400             


Gly Glu  Tyr Val Cys Arg Val  Leu Gly Ser Ser Val  Pro Leu Glu 
    2405                 2410                 2415             


Ala Ser  Val Leu Val Thr Ile  Glu Pro Ala Gly Ser  Val Pro Ala 
    2420                 2425                 2430             


Leu Gly  Val Thr Pro Thr Val  Arg Ile Glu Ser Ser  Ser Ser Gln 
    2435                 2440                 2445             


Val Ala  Glu Gly Gln Thr Leu  Asp Leu Asn Cys Leu  Val Ala Gly 
    2450                 2455                 2460             


Gln Ala  His Ala Gln Val Thr  Trp His Lys Arg Gly  Gly Ser Leu 
    2465                 2470                 2475             


Pro Ala  Arg His Gln Val His  Gly Ser Arg Leu Arg  Leu Leu Gln 
    2480                 2485                 2490             


Val Thr  Pro Ala Asp Ser Gly  Glu Tyr Val Cys Arg  Val Val Gly 
    2495                 2500                 2505             


Ser Ser  Gly Thr Gln Glu Ala  Ser Val Leu Val Thr  Ile Gln Gln 
    2510                 2515                 2520             


Arg Leu  Ser Gly Ser His Ser  Gln Gly Val Ala Tyr  Pro Val Arg 
    2525                 2530                 2535             


Ile Glu  Ser Ser Ser Ala Ser  Leu Ala Asn Gly His  Thr Leu Asp 
    2540                 2545                 2550             


Leu Asn  Cys Leu Val Ala Ser  Gln Ala Pro His Thr  Ile Thr Trp 
    2555                 2560                 2565             


Tyr Lys  Arg Gly Gly Ser Leu  Pro Ser Arg His Gln  Ile Val Gly 
    2570                 2575                 2580             


Ser Arg  Leu Arg Ile Pro Gln  Val Thr Pro Ala Asp  Ser Gly Glu 
    2585                 2590                 2595             


Tyr Val  Cys His Val Ser Asn  Gly Ala Gly Ser Arg  Glu Thr Ser 
    2600                 2605                 2610             


Leu Ile  Val Thr Ile Gln Gly  Ser Gly Ser Ser His  Val Pro Ser 
    2615                 2620                 2625             


Val Ser  Pro Pro Ile Arg Ile  Glu Ser Ser Ser Pro  Thr Val Val 
    2630                 2635                 2640             


Glu Gly  Gln Thr Leu Asp Leu  Asn Cys Val Val Ala  Arg Gln Pro 
    2645                 2650                 2655             


Gln Ala  Ile Ile Thr Trp Tyr  Lys Arg Gly Gly Ser  Leu Pro Ser 
    2660                 2665                 2670             


Arg His  Gln Thr His Gly Ser  His Leu Arg Leu His  Gln Met Ser 
    2675                 2680                 2685             


Val Ala  Asp Ser Gly Glu Tyr  Val Cys Arg Ala Asn  Asn Asn Ile 
    2690                 2695                 2700             


Asp Ala  Leu Glu Ala Ser Ile  Val Ile Ser Val Ser  Pro Ser Ala 
    2705                 2710                 2715             


Gly Ser  Pro Ser Ala Pro Gly  Ser Ser Met Pro Ile  Arg Ile Glu 
    2720                 2725                 2730             


Ser Ser  Ser Ser His Val Ala  Glu Gly Glu Thr Leu  Asp Leu Asn 
    2735                 2740                 2745             


Cys Val  Val Pro Gly Gln Ala  His Ala Gln Val Thr  Trp His Lys 
    2750                 2755                 2760             


Arg Gly  Gly Ser Leu Pro Ser  His His Gln Thr Arg  Gly Ser Arg 
    2765                 2770                 2775             


Leu Arg  Leu His His Val Ser  Pro Ala Asp Ser Gly  Glu Tyr Val 
    2780                 2785                 2790             


Cys Arg  Val Met Gly Ser Ser  Gly Pro Leu Glu Ala  Ser Val Leu 
    2795                 2800                 2805             


Val Thr  Ile Glu Ala Ser Gly  Ser Ser Ala Val His  Val Pro Ala 
    2810                 2815                 2820             


Pro Gly  Gly Ala Pro Pro Ile  Arg Ile Glu Pro Ser  Ser Ser Arg 
    2825                 2830                 2835             


Val Ala  Glu Gly Gln Thr Leu  Asp Leu Lys Cys Val  Val Pro Gly 
    2840                 2845                 2850             


Gln Ala  His Ala Gln Val Thr  Trp His Lys Arg Gly  Gly Asn Leu 
    2855                 2860                 2865             


Pro Ala  Arg His Gln Val His  Gly Pro Leu Leu Arg  Leu Asn Gln 
    2870                 2875                 2880             


Val Ser  Pro Ala Asp Ser Gly  Glu Tyr Ser Cys Gln  Val Thr Gly 
    2885                 2890                 2895             


Ser Ser  Gly Thr Leu Glu Ala  Ser Val Leu Val Thr  Ile Glu Pro 
    2900                 2905                 2910             


Ser Ser  Pro Gly Pro Ile Pro  Ala Pro Gly Leu Ala  Gln Pro Ile 
    2915                 2920                 2925             


Tyr Ile  Glu Ala Ser Ser Ser  His Val Thr Glu Gly  Gln Thr Leu 
    2930                 2935                 2940             


Asp Leu  Asn Cys Val Val Pro  Gly Gln Ala His Ala  Gln Val Thr 
    2945                 2950                 2955             


Trp Tyr  Lys Arg Gly Gly Ser  Leu Pro Ala Arg His  Gln Thr His 
    2960                 2965                 2970             


Gly Ser  Gln Leu Arg Leu His  Leu Val Ser Pro Ala  Asp Ser Gly 
    2975                 2980                 2985             


Glu Tyr  Val Cys Arg Ala Ala  Ser Gly Pro Gly Pro  Glu Gln Glu 
    2990                 2995                 3000             


Ala Ser  Phe Thr Val Thr Val  Pro Pro Ser Glu Gly  Ser Ser Tyr 
    3005                 3010                 3015             


Arg Leu  Arg Ser Pro Val Ile  Ser Ile Asp Pro Pro  Ser Ser Thr 
    3020                 3025                 3030             


Val Gln  Gln Gly Gln Asp Ala  Ser Phe Lys Cys Leu  Ile His Asp 
    3035                 3040                 3045             


Gly Ala  Ala Pro Ile Ser Leu  Glu Trp Lys Thr Arg  Asn Gln Glu 
    3050                 3055                 3060             


Leu Glu  Asp Asn Val His Ile  Ser Pro Asn Gly Ser  Ile Ile Thr 
    3065                 3070                 3075             


Ile Val  Gly Thr Arg Pro Ser  Asn His Gly Thr Tyr  Arg Cys Val 
    3080                 3085                 3090             


Ala Ser  Asn Ala Tyr Gly Val  Ala Gln Ser Val Val  Asn Leu Ser 
    3095                 3100                 3105             


Val His  Gly Pro Pro Thr Val  Ser Val Leu Pro Glu  Gly Pro Val 
    3110                 3115                 3120             


Trp Val  Lys Val Gly Lys Ala  Val Thr Leu Glu Cys  Val Ser Ala 
    3125                 3130                 3135             


Gly Glu  Pro Arg Ser Ser Ala  Arg Trp Thr Arg Ile  Ser Ser Thr 
    3140                 3145                 3150             


Pro Ala  Lys Leu Glu Gln Arg  Thr Tyr Gly Leu Met  Asp Ser His 
    3155                 3160                 3165             


Ala Val  Leu Gln Ile Ser Ser  Ala Lys Pro Ser Asp  Ala Gly Thr 
    3170                 3175                 3180             


Tyr Val  Cys Leu Ala Gln Asn  Ala Leu Gly Thr Ala  Gln Lys Gln 
    3185                 3190                 3195             


Val Glu  Val Ile Val Asp Thr  Gly Ala Met Ala Pro  Gly Ala Pro 
    3200                 3205                 3210             


Gln Val  Gln Ala Glu Glu Ala  Glu Leu Thr Val Glu  Ala Gly His 
    3215                 3220                 3225             


Thr Ala  Thr Leu Arg Cys Ser  Ala Thr Gly Ser Pro  Ala Pro Thr 
    3230                 3235                 3240             


Ile His  Trp Ser Lys Leu Arg  Ser Pro Leu Pro Trp  Gln His Arg 
    3245                 3250                 3255             


Leu Glu  Gly Asp Thr Leu Ile  Ile Pro Arg Val Ala  Gln Gln Asp 
    3260                 3265                 3270             


Ser Gly  Gln Tyr Ile Cys Asn  Ala Thr Ser Pro Ala  Gly His Ala 
    3275                 3280                 3285             


Glu Ala  Thr Ile Ile Leu His  Val Glu Ser Pro Pro  Tyr Ala Thr 
    3290                 3295                 3300             


Thr Val  Pro Glu His Ala Ser  Val Gln Ala Gly Glu  Thr Val Gln 
    3305                 3310                 3315             


Leu Gln  Cys Leu Ala His Gly  Thr Pro Pro Leu Thr  Phe Gln Trp 
    3320                 3325                 3330             


Ser Arg  Val Gly Ser Ser Leu  Pro Gly Arg Ala Thr  Ala Arg Asn 
    3335                 3340                 3345             


Glu Leu  Leu His Phe Glu Arg  Ala Ala Pro Glu Asp  Ser Gly Arg 
    3350                 3355                 3360             


Tyr Arg  Cys Arg Val Thr Asn  Lys Val Gly Ser Ala  Glu Ala Phe 
    3365                 3370                 3375             


Ala Gln  Leu Leu Val Gln Gly  Pro Pro Gly Ser Leu  Pro Ala Thr 
    3380                 3385                 3390             


Ser Ile  Pro Ala Gly Ser Thr  Pro Thr Val Gln Val  Thr Pro Gln 
    3395                 3400                 3405             


Leu Glu  Thr Lys Ser Ile Gly  Ala Ser Val Glu Phe  His Cys Ala 
    3410                 3415                 3420             


Val Pro  Ser Asp Arg Gly Thr  Gln Leu Arg Trp Phe  Lys Glu Gly 
    3425                 3430                 3435             


Gly Gln  Leu Pro Pro Gly His  Ser Val Gln Asp Gly  Val Leu Arg 
    3440                 3445                 3450             


Ile Gln  Asn Leu Asp Gln Ser  Cys Gln Gly Thr Tyr  Ile Cys Gln 
    3455                 3460                 3465             


Ala His  Gly Pro Trp Gly Lys  Ala Gln Ala Ser Ala  Gln Leu Val 
    3470                 3475                 3480             


Ile Gln  Ala Leu Pro Ser Val  Leu Ile Asn Ile Arg  Thr Ser Val 
    3485                 3490                 3495             


Gln Thr  Val Val Val Gly His  Ala Val Glu Phe Glu  Cys Leu Ala 
    3500                 3505                 3510             


Leu Gly  Asp Pro Lys Pro Gln  Val Thr Trp Ser Lys  Val Gly Gly 
    3515                 3520                 3525             


His Leu  Arg Pro Gly Ile Val  Gln Ser Gly Gly Val  Val Arg Ile 
    3530                 3535                 3540             


Ala His  Val Glu Leu Ala Asp  Ala Gly Gln Tyr Arg  Cys Thr Ala 
    3545                 3550                 3555             


Thr Asn  Ala Ala Gly Thr Thr  Gln Ser His Val Leu  Leu Leu Val 
    3560                 3565                 3570             


Gln Ala  Leu Pro Gln Ile Ser  Met Pro Gln Glu Val  Arg Val Pro 
    3575                 3580                 3585             


Ala Gly  Ser Ala Ala Val Phe  Pro Cys Ile Ala Ser  Gly Tyr Pro 
    3590                 3595                 3600             


Thr Pro  Asp Ile Ser Trp Ser  Lys Leu Asp Gly Ser  Leu Pro Pro 
    3605                 3610                 3615             


Asp Ser  Arg Leu Glu Asn Asn  Met Leu Met Leu Pro  Ser Val Arg 
    3620                 3625                 3630             


Pro Gln  Asp Ala Gly Thr Tyr  Val Cys Thr Ala Thr  Asn Arg Gln 
    3635                 3640                 3645             


Gly Lys  Val Lys Ala Phe Ala  His Leu Gln Val Pro  Glu Arg Val 
    3650                 3655                 3660             


Val Pro  Tyr Phe Thr Gln Thr  Pro Tyr Ser Phe Leu  Pro Leu Pro 
    3665                 3670                 3675             


Thr Ile  Lys Asp Ala Tyr Arg  Lys Phe Glu Ile Lys  Ile Thr Phe 
    3680                 3685                 3690             


Arg Pro  Asp Ser Ala Asp Gly  Met Leu Leu Tyr Asn  Gly Gln Lys 
    3695                 3700                 3705             


Arg Val  Pro Gly Ser Pro Thr  Asn Leu Ala Asn Arg  Gln Pro Asp 
    3710                 3715                 3720             


Phe Ile  Ser Phe Gly Leu Val  Gly Gly Arg Pro Glu  Phe Arg Phe 
    3725                 3730                 3735             


Asp Ala  Gly Ser Gly Met Ala  Thr Ile Arg His Pro  Thr Pro Leu 
    3740                 3745                 3750             


Ala Leu  Gly His Phe His Thr  Val Thr Leu Leu Arg  Ser Leu Thr 
    3755                 3760                 3765             


Gln Gly  Ser Leu Ile Val Gly  Asp Leu Ala Pro Val  Asn Gly Thr 
    3770                 3775                 3780             


Ser Gln  Gly Lys Phe Gln Gly  Leu Asp Leu Asn Glu  Glu Leu Tyr 
    3785                 3790                 3795             


Leu Gly  Gly Tyr Pro Asp Tyr  Gly Ala Ile Pro Lys  Ala Gly Leu 
    3800                 3805                 3810             


Ser Ser  Gly Phe Ile Gly Cys  Val Arg Glu Leu Arg  Ile Gln Gly 
    3815                 3820                 3825             


Glu Glu  Ile Val Phe His Asp  Leu Asn Leu Thr Ala  His Gly Ile 
    3830                 3835                 3840             


Ser His  Cys Pro Thr Cys Arg  Asp Arg Pro Cys Gln  Asn Gly Gly 
    3845                 3850                 3855             


Gln Cys  His Asp Ser Glu Ser  Ser Ser Tyr Val Cys  Val Cys Pro 
    3860                 3865                 3870             


Ala Gly  Phe Thr Gly Ser Arg  Cys Glu His Ser Gln  Ala Leu His 
    3875                 3880                 3885             


Cys His  Pro Glu Ala Cys Gly  Pro Asp Ala Thr Cys  Val Asn Arg 
    3890                 3895                 3900             


Pro Asp  Gly Arg Gly Tyr Thr  Cys Arg Cys His Leu  Gly Arg Ser 
    3905                 3910                 3915             


Gly Leu  Arg Cys Glu Glu Gly  Val Thr Val Thr Thr  Pro Ser Leu 
    3920                 3925                 3930             


Ser Gly  Ala Gly Ser Tyr Leu  Ala Leu Pro Ala Leu  Thr Asn Thr 
    3935                 3940                 3945             


His His  Glu Leu Arg Leu Asp  Val Glu Phe Lys Pro  Leu Ala Pro 
    3950                 3955                 3960             


Asp Gly  Val Leu Leu Phe Ser  Gly Gly Lys Ser Gly  Pro Val Glu 
    3965                 3970                 3975             


Asp Phe  Val Ser Leu Ala Met  Val Gly Gly His Leu  Glu Phe Arg 
    3980                 3985                 3990             


Tyr Glu  Leu Gly Ser Gly Leu  Ala Val Leu Arg Ser  Ala Glu Pro 
    3995                 4000                 4005             


Leu Ala  Leu Gly Arg Trp His  Arg Val Ser Ala Glu  Arg Leu Asn 
    4010                 4015                 4020             


Lys Asp  Gly Ser Leu Arg Val  Asn Gly Gly Arg Pro  Val Leu Arg 
    4025                 4030                 4035             


Ser Ser  Pro Gly Lys Ser Gln  Gly Leu Asn Leu His  Thr Leu Leu 
    4040                 4045                 4050             


Tyr Leu  Gly Gly Val Glu Pro  Ser Val Pro Leu Ser  Pro Ala Thr 
    4055                 4060                 4065             


Asn Met  Ser Ala His Phe Arg  Gly Cys Val Gly Glu  Val Ser Val 
    4070                 4075                 4080             


Asn Gly  Lys Arg Leu Asp Leu  Thr Tyr Ser Phe Leu  Gly Ser Gln 
    4085                 4090                 4095             


Gly Ile  Gly Gln Cys Tyr Asp  Ser Ser Pro Cys Glu  Arg Gln Pro 
    4100                 4105                 4110             


Cys Gln  His Gly Ala Thr Cys  Met Pro Ala Gly Glu  Tyr Glu Phe 
    4115                 4120                 4125             


Gln Cys  Leu Cys Arg Asp Gly  Phe Lys Gly Asp Leu  Cys Glu His 
    4130                 4135                 4140             


Glu Glu  Asn Pro Cys Gln Leu  Arg Glu Pro Cys Leu  His Gly Gly 
    4145                 4150                 4155             


Thr Cys  Gln Gly Thr Arg Cys  Leu Cys Leu Pro Gly  Phe Ser Gly 
    4160                 4165                 4170             


Pro Arg  Cys Gln Gln Gly Ser  Gly His Gly Ile Ala  Glu Ser Asp 
    4175                 4180                 4185             


Trp His  Leu Glu Gly Ser Gly  Gly Asn Asp Ala Pro  Gly Gln Tyr 
    4190                 4195                 4200             


Gly Ala  Tyr Phe His Asp Asp  Gly Phe Leu Ala Phe  Pro Gly His 
    4205                 4210                 4215             


Val Phe  Ser Arg Ser Leu Pro  Glu Val Pro Glu Thr  Ile Glu Leu 
    4220                 4225                 4230             


Glu Val  Arg Thr Ser Thr Ala  Ser Gly Leu Leu Leu  Trp Gln Gly 
    4235                 4240                 4245             


Val Glu  Val Gly Glu Ala Gly  Gln Gly Lys Asp Phe  Ile Ser Leu 
    4250                 4255                 4260             


Gly Leu  Gln Asp Gly His Leu  Val Phe Arg Tyr Gln  Leu Gly Ser 
    4265                 4270                 4275             


Gly Glu  Ala Arg Leu Val Ser  Glu Asp Pro Ile Asn  Asp Gly Glu 
    4280                 4285                 4290             


Trp His  Arg Val Thr Ala Leu  Arg Glu Gly Arg Arg  Gly Ser Ile 
    4295                 4300                 4305             


Gln Val  Asp Gly Glu Glu Leu  Val Ser Gly Arg Ser  Pro Gly Pro 
    4310                 4315                 4320             


Asn Val  Ala Val Asn Ala Lys  Gly Ser Val Tyr Ile  Gly Gly Ala 
    4325                 4330                 4335             


Pro Asp  Val Ala Thr Leu Thr  Gly Gly Arg Phe Ser  Ser Gly Ile 
    4340                 4345                 4350             


Thr Gly  Cys Val Lys Asn Leu  Val Leu His Ser Ala  Arg Pro Gly 
    4355                 4360                 4365             


Ala Pro  Pro Pro Gln Pro Leu  Asp Leu Gln His Arg  Ala Gln Ala 
    4370                 4375                 4380             


Gly Ala  Asn Thr Arg Pro Cys  Pro Ser 
    4385                 4390         


<210>  2
<211>  4391
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu 
            20                  25                  30          


Ser Leu Pro Glu Asp Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp 
        35                  40                  45              


Thr His Ser Tyr Leu Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile 
    50                  55                  60                  


Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp Phe Gln 
65                  70                  75                  80  


Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg Ser Ile Glu Tyr 
                85                  90                  95      


Ser Pro Gln Leu Glu Asp Ala Gly Ser Arg Glu Phe Arg Glu Val Ser 
            100                 105                 110         


Glu Ala Val Val Asp Thr Leu Glu Ser Glu Tyr Leu Lys Ile Pro Gly 
        115                 120                 125             


Asp Gln Val Val Ser Val Val Phe Ile Lys Glu Leu Asp Gly Trp Val 
    130                 135                 140                 


Phe Val Glu Leu Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln 
145                 150                 155                 160 


Ile Gln Glu Met Leu Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser 
                165                 170                 175     


Tyr Val Thr Ser Pro Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val 
            180                 185                 190         


Pro Gln Phe Pro Arg Ala Cys Thr Glu Ala Glu Phe Ala Cys His Ser 
        195                 200                 205             


Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp Arg Arg Pro Asp 
    210                 215                 220                 


Cys Arg Asp Met Ser Asp Glu Leu Asn Cys Glu Glu Pro Val Leu Gly 
225                 230                 235                 240 


Ile Ser Pro Thr Phe Ser Leu Leu Val Glu Thr Thr Ser Leu Pro Pro 
                245                 250                 255     


Arg Pro Glu Thr Thr Ile Met Arg Gln Pro Pro Val Thr His Ala Pro 
            260                 265                 270         


Gln Pro Leu Leu Pro Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln 
        275                 280                 285             


Glu Ala Ala Cys Arg Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys 
    290                 295                 300                 


Asp Gly Gln Glu Asp Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly 
305                 310                 315                 320 


Pro Pro Pro Pro Cys Glu Pro Asn Glu Phe Pro Cys Gly Asn Gly His 
                325                 330                 335     


Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp Phe Asp Cys Glu Asp 
            340                 345                 350         


Arg Thr Asp Glu Ala Asn Cys Pro Thr Lys Arg Pro Glu Glu Val Cys 
        355                 360                 365             


Gly Pro Thr Gln Phe Arg Cys Val Ser Thr Asn Met Cys Ile Pro Ala 
    370                 375                 380                 


Ser Phe His Cys Asp Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu 
385                 390                 395                 400 


Phe Gly Cys Met Pro Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile 
                405                 410                 415     


Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly 
            420                 425                 430         


Val Pro Thr Pro Ile Ile Asn Trp Arg Leu Asn Trp Gly His Ile Pro 
        435                 440                 445             


Ser His Pro Arg Val Thr Val Thr Ser Glu Gly Gly Arg Gly Thr Leu 
    450                 455                 460                 


Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly Ala Tyr Thr Cys Glu 
465                 470                 475                 480 


Ala Met Asn Ala Arg Gly Met Val Phe Gly Ile Pro Asp Gly Val Leu 
                485                 490                 495     


Glu Leu Val Pro Gln Arg Gly Pro Cys Pro Asp Gly His Phe Tyr Leu 
            500                 505                 510         


Glu His Ser Ala Ala Cys Leu Pro Cys Phe Cys Phe Gly Ile Thr Ser 
        515                 520                 525             


Val Cys Gln Ser Thr Arg Arg Phe Arg Asp Gln Ile Arg Leu Arg Phe 
    530                 535                 540                 


Asp Gln Pro Asp Asp Phe Lys Gly Val Asn Val Thr Met Pro Ala Gln 
545                 550                 555                 560 


Pro Gly Thr Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp Pro Ser 
                565                 570                 575     


Leu His Glu Phe Gln Leu Val Asp Leu Ser Arg Arg Phe Leu Val His 
            580                 585                 590         


Asp Ser Phe Trp Ala Leu Pro Glu Gln Phe Leu Gly Asn Lys Val Asp 
        595                 600                 605             


Ser Tyr Gly Gly Ser Leu Arg Tyr Asn Val Arg Tyr Glu Leu Ala Arg 
    610                 615                 620                 


Gly Met Leu Glu Pro Val Gln Arg Pro Asp Val Val Leu Met Gly Ala 
625                 630                 635                 640 


Gly Tyr Arg Leu Leu Ser Arg Gly His Thr Pro Thr Gln Pro Gly Ala 
                645                 650                 655     


Leu Asn Gln Arg Gln Val Gln Phe Ser Glu Glu His Trp Val His Glu 
            660                 665                 670         


Ser Gly Arg Pro Val Gln Arg Ala Glu Leu Leu Gln Val Leu Gln Ser 
        675                 680                 685             


Leu Glu Ala Val Leu Ile Gln Thr Val Tyr Asn Thr Lys Met Ala Ser 
    690                 695                 700                 


Val Gly Leu Ser Asp Ile Ala Met Asp Thr Thr Val Thr His Ala Thr 
705                 710                 715                 720 


Ser His Gly Arg Ala His Ser Val Glu Glu Cys Arg Cys Pro Ile Gly 
                725                 730                 735     


Tyr Ser Gly Leu Ser Cys Glu Ser Cys Asp Ala His Phe Thr Arg Val 
            740                 745                 750         


Pro Gly Gly Pro Tyr Leu Gly Thr Cys Ser Gly Cys Asn Cys Asn Gly 
        755                 760                 765             


His Ala Ser Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn Cys Gln 
    770                 775                 780                 


His Asn Thr Glu Gly Pro Gln Cys Asn Lys Cys Lys Ala Gly Phe Phe 
785                 790                 795                 800 


Gly Asp Ala Met Lys Ala Thr Ala Thr Ser Cys Arg Pro Cys Pro Cys 
                805                 810                 815     


Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys Phe Leu Asp 
            820                 825                 830         


Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala Pro Gly Tyr Thr Gly 
        835                 840                 845             


Arg Arg Cys Glu Ser Cys Ala Pro Gly Tyr Glu Gly Asn Pro Ile Gln 
    850                 855                 860                 


Pro Gly Gly Lys Cys Arg Pro Val Asn Gln Glu Ile Val Arg Cys Asp 
865                 870                 875                 880 


Glu Arg Gly Ser Met Gly Thr Ser Gly Glu Ala Cys Arg Cys Lys Asn 
                885                 890                 895     


Asn Val Val Gly Arg Leu Cys Asn Glu Cys Ala Asp Gly Ser Phe His 
            900                 905                 910         


Leu Ser Thr Arg Asn Pro Asp Gly Cys Leu Lys Cys Phe Cys Met Gly 
        915                 920                 925             


Val Ser Arg His Cys Thr Ser Ser Ser Trp Ser Arg Ala Gln Leu His 
    930                 935                 940                 


Gly Ala Ser Glu Glu Pro Gly His Phe Ser Leu Thr Asn Ala Ala Ser 
945                 950                 955                 960 


Thr His Thr Thr Asn Glu Gly Ile Phe Ser Pro Thr Pro Gly Glu Leu 
                965                 970                 975     


Gly Phe Ser Ser Phe His Arg Leu Leu Ser Gly Pro Tyr Phe Trp Ser 
            980                 985                 990         


Leu Pro Ser Arg Phe Leu Gly Asp  Lys Val Thr Ser Tyr  Gly Gly Glu 
        995                 1000                 1005             


Leu Arg  Phe Thr Val Thr Gln  Arg Ser Gln Pro Gly  Ser Thr Pro 
    1010                 1015                 1020             


Leu His  Gly Gln Pro Leu Val  Val Leu Gln Gly Asn  Asn Ile Ile 
    1025                 1030                 1035             


Leu Glu  His His Val Ala Gln  Glu Pro Ser Pro Gly  Gln Pro Ser 
    1040                 1045                 1050             


Thr Phe  Ile Val Pro Phe Arg  Glu Gln Ala Trp Gln  Arg Pro Asp 
    1055                 1060                 1065             


Gly Gln  Pro Ala Thr Arg Glu  His Leu Leu Met Ala  Leu Ala Gly 
    1070                 1075                 1080             


Ile Asp  Thr Leu Leu Ile Arg  Ala Ser Tyr Ala Gln  Gln Pro Ala 
    1085                 1090                 1095             


Glu Ser  Arg Val Ser Gly Ile  Ser Met Asp Val Ala  Val Pro Glu 
    1100                 1105                 1110             


Glu Thr  Gly Gln Asp Pro Ala  Leu Glu Val Glu Gln  Cys Ser Cys 
    1115                 1120                 1125             


Pro Pro  Gly Tyr Arg Gly Pro  Ser Cys Gln Asp Cys  Asp Thr Gly 
    1130                 1135                 1140             


Tyr Thr  Arg Thr Pro Ser Gly  Leu Tyr Leu Gly Thr  Cys Glu Arg 
    1145                 1150                 1155             


Cys Ser  Cys His Gly His Ser  Glu Ala Cys Glu Pro  Glu Thr Gly 
    1160                 1165                 1170             


Ala Cys  Gln Gly Cys Gln His  His Thr Glu Gly Pro  Arg Cys Glu 
    1175                 1180                 1185             


Gln Cys  Gln Pro Gly Tyr Tyr  Gly Asp Ala Gln Arg  Gly Thr Pro 
    1190                 1195                 1200             


Gln Asp  Cys Gln Leu Cys Pro  Cys Tyr Gly Asp Pro  Ala Ala Gly 
    1205                 1210                 1215             


Gln Ala  Ala His Thr Cys Phe  Leu Asp Thr Asp Gly  His Pro Thr 
    1220                 1225                 1230             


Cys Asp  Ala Cys Ser Pro Gly  His Ser Gly Arg His  Cys Glu Arg 
    1235                 1240                 1245             


Cys Ala  Pro Gly Tyr Tyr Gly  Asn Pro Ser Gln Gly  Gln Pro Cys 
    1250                 1255                 1260             


Gln Arg  Asp Ser Gln Val Pro  Gly Pro Ile Gly Cys  Asn Cys Asp 
    1265                 1270                 1275             


Pro Gln  Gly Ser Val Ser Ser  Gln Cys Asp Ala Ala  Gly Gln Cys 
    1280                 1285                 1290             


Gln Cys  Lys Ala Gln Val Glu  Gly Leu Thr Cys Ser  His Cys Arg 
    1295                 1300                 1305             


Pro His  His Phe His Leu Ser  Ala Ser Asn Pro Asp  Gly Cys Leu 
    1310                 1315                 1320             


Pro Cys  Phe Cys Met Gly Ile  Thr Gln Gln Cys Ala  Ser Ser Ala 
    1325                 1330                 1335             


Tyr Thr  Arg His Leu Ile Ser  Thr His Phe Ala Pro  Gly Asp Phe 
    1340                 1345                 1350             


Gln Gly  Phe Ala Leu Val Asn  Pro Gln Arg Asn Ser  Arg Leu Thr 
    1355                 1360                 1365             


Gly Glu  Phe Thr Val Glu Pro  Val Pro Glu Gly Ala  Gln Leu Ser 
    1370                 1375                 1380             


Phe Gly  Asn Phe Ala Gln Leu  Gly His Glu Ser Phe  Tyr Trp Gln 
    1385                 1390                 1395             


Leu Pro  Glu Thr Tyr Gln Gly  Asp Lys Val Ala Ala  Tyr Gly Gly 
    1400                 1405                 1410             


Lys Leu  Arg Tyr Thr Leu Ser  Tyr Thr Ala Gly Pro  Gln Gly Ser 
    1415                 1420                 1425             


Pro Leu  Ser Asp Pro Asp Val  Gln Ile Thr Gly Asn  Asn Ile Met 
    1430                 1435                 1440             


Leu Val  Ala Ser Gln Pro Ala  Leu Gln Gly Pro Glu  Arg Arg Ser 
    1445                 1450                 1455             


Tyr Glu  Ile Met Phe Arg Glu  Glu Phe Trp Arg Arg  Pro Asp Gly 
    1460                 1465                 1470             


Gln Pro  Ala Thr Arg Glu His  Leu Leu Met Ala Leu  Ala Asp Leu 
    1475                 1480                 1485             


Asp Glu  Leu Leu Ile Arg Ala  Thr Phe Ser Ser Val  Pro Leu Ala 
    1490                 1495                 1500             


Ala Ser  Ile Ser Ala Val Ser  Leu Glu Val Ala Gln  Pro Gly Pro 
    1505                 1510                 1515             


Ser Asn  Arg Pro Arg Ala Leu  Glu Val Glu Glu Cys  Arg Cys Pro 
    1520                 1525                 1530             


Pro Gly  Tyr Ile Gly Leu Ser  Cys Gln Asp Cys Ala  Pro Gly Tyr 
    1535                 1540                 1545             


Thr Arg  Thr Gly Ser Gly Leu  Tyr Leu Gly His Cys  Glu Leu Cys 
    1550                 1555                 1560             


Glu Cys  Asn Gly His Ser Asp  Leu Cys His Pro Glu  Thr Gly Ala 
    1565                 1570                 1575             


Cys Ser  Gln Cys Gln His Asn  Ala Ala Gly Glu Phe  Cys Glu Leu 
    1580                 1585                 1590             


Cys Ala  Pro Gly Tyr Tyr Gly  Asp Ala Thr Ala Gly  Thr Pro Glu 
    1595                 1600                 1605             


Asp Cys  Gln Pro Cys Ala Cys  Pro Leu Thr Asn Pro  Glu Asn Met 
    1610                 1615                 1620             


Phe Ser  Arg Thr Cys Glu Ser  Leu Gly Ala Gly Gly  Tyr Arg Cys 
    1625                 1630                 1635             


Thr Ala  Cys Glu Pro Gly Tyr  Thr Gly Gln Tyr Cys  Glu Gln Cys 
    1640                 1645                 1650             


Gly Pro  Gly Tyr Val Gly Asn  Pro Ser Val Gln Gly  Gly Gln Cys 
    1655                 1660                 1665             


Leu Pro  Glu Thr Asn Gln Ala  Pro Leu Val Val Glu  Val His Pro 
    1670                 1675                 1680             


Ala Arg  Ser Ile Val Pro Gln  Gly Gly Ser His Ser  Leu Arg Cys 
    1685                 1690                 1695             


Gln Val  Ser Gly Ser Pro Pro  His Tyr Phe Tyr Trp  Ser Arg Glu 
    1700                 1705                 1710             


Asp Gly  Arg Pro Val Pro Ser  Gly Thr Gln Gln Arg  His Gln Gly 
    1715                 1720                 1725             


Ser Glu  Leu His Phe Pro Ser  Val Gln Pro Ser Asp  Ala Gly Val 
    1730                 1735                 1740             


Tyr Ile  Cys Thr Cys Arg Asn  Leu His Gln Ser Asn  Thr Ser Arg 
    1745                 1750                 1755             


Ala Glu  Leu Leu Val Thr Glu  Ala Pro Ser Lys Pro  Ile Thr Val 
    1760                 1765                 1770             


Thr Val  Glu Glu Gln Arg Ser  Gln Ser Val Arg Pro  Gly Ala Asp 
    1775                 1780                 1785             


Val Thr  Phe Ile Cys Thr Ala  Lys Ser Lys Ser Pro  Ala Tyr Thr 
    1790                 1795                 1800             


Leu Val  Trp Thr Arg Leu His  Asn Gly Lys Leu Pro  Thr Arg Ala 
    1805                 1810                 1815             


Met Asp  Phe Asn Gly Ile Leu  Thr Ile Arg Asn Val  Gln Leu Ser 
    1820                 1825                 1830             


Asp Ala  Gly Thr Tyr Val Cys  Thr Gly Ser Asn Met  Phe Ala Met 
    1835                 1840                 1845             


Asp Gln  Gly Thr Ala Thr Leu  His Val Gln Ala Ser  Gly Thr Leu 
    1850                 1855                 1860             


Ser Ala  Pro Val Val Ser Ile  His Pro Pro Gln Leu  Thr Val Gln 
    1865                 1870                 1875             


Pro Gly  Gln Leu Ala Glu Phe  Arg Cys Ser Ala Thr  Gly Ser Pro 
    1880                 1885                 1890             


Thr Pro  Thr Leu Glu Trp Thr  Gly Gly Pro Gly Gly  Gln Leu Pro 
    1895                 1900                 1905             


Ala Lys  Ala Gln Ile His Gly  Gly Ile Leu Arg Leu  Pro Ala Val 
    1910                 1915                 1920             


Glu Pro  Thr Asp Gln Ala Gln  Tyr Leu Cys Arg Ala  His Ser Ser 
    1925                 1930                 1935             


Ala Gly  Gln Gln Val Ala Arg  Ala Val Leu His Val  His Gly Gly 
    1940                 1945                 1950             


Gly Gly  Pro Arg Val Gln Val  Ser Pro Glu Arg Thr  Gln Val His 
    1955                 1960                 1965             


Ala Gly  Arg Thr Val Arg Leu  Tyr Cys Arg Ala Ala  Gly Val Pro 
    1970                 1975                 1980             


Ser Ala  Thr Ile Thr Trp Arg  Lys Glu Gly Gly Ser  Leu Pro Pro 
    1985                 1990                 1995             


Gln Ala  Arg Ser Glu Arg Thr  Asp Ile Ala Thr Leu  Leu Ile Pro 
    2000                 2005                 2010             


Ala Ile  Thr Thr Ala Asp Ala  Gly Phe Tyr Leu Cys  Val Ala Thr 
    2015                 2020                 2025             


Ser Pro  Ala Gly Thr Ala Gln  Ala Arg Ile Gln Val  Val Val Leu 
    2030                 2035                 2040             


Ser Ala  Ser Asp Ala Ser Pro  Pro Pro Val Lys Ile  Glu Ser Ser 
    2045                 2050                 2055             


Ser Pro  Ser Val Thr Glu Gly  Gln Thr Leu Asp Leu  Asn Cys Val 
    2060                 2065                 2070             


Val Ala  Gly Ser Ala His Ala  Gln Val Thr Trp Tyr  Arg Arg Gly 
    2075                 2080                 2085             


Gly Ser  Leu Pro Pro His Thr  Gln Val His Gly Ser  Arg Leu Arg 
    2090                 2095                 2100             


Leu Pro  Gln Val Ser Pro Ala  Asp Ser Gly Glu Tyr  Val Cys Arg 
    2105                 2110                 2115             


Val Glu  Asn Gly Ser Gly Pro  Lys Glu Ala Ser Ile  Thr Val Ser 
    2120                 2125                 2130             


Val Leu  His Gly Thr His Ser  Gly Pro Ser Tyr Thr  Pro Val Pro 
    2135                 2140                 2145             


Gly Ser  Thr Arg Pro Ile Arg  Ile Glu Pro Ser Ser  Ser His Val 
    2150                 2155                 2160             


Ala Glu  Gly Gln Thr Leu Asp  Leu Asn Cys Val Val  Pro Gly Gln 
    2165                 2170                 2175             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro 
    2180                 2185                 2190             


Ala Arg  His Gln Thr His Gly  Ser Leu Leu Arg Leu  His Gln Val 
    2195                 2200                 2205             


Thr Pro  Ala Asp Ser Gly Glu  Tyr Val Cys His Val  Val Gly Thr 
    2210                 2215                 2220             


Ser Gly  Pro Leu Glu Ala Ser  Val Leu Val Thr Ile  Glu Ala Ser 
    2225                 2230                 2235             


Val Ile  Pro Gly Pro Ile Pro  Pro Val Arg Ile Glu  Ser Ser Ser 
    2240                 2245                 2250             


Ser Thr  Val Ala Glu Gly Gln  Thr Leu Asp Leu Ser  Cys Val Val 
    2255                 2260                 2265             


Ala Gly  Gln Ala His Ala Gln  Val Thr Trp Tyr Lys  Arg Gly Gly 
    2270                 2275                 2280             


Ser Leu  Pro Ala Arg His Gln  Val Arg Gly Ser Arg  Leu Tyr Ile 
    2285                 2290                 2295             


Phe Gln  Ala Ser Pro Ala Asp  Ala Gly Gln Tyr Val  Cys Arg Ala 
    2300                 2305                 2310             


Ser Asn  Gly Met Glu Ala Ser  Ile Thr Val Thr Val  Thr Gly Thr 
    2315                 2320                 2325             


Gln Gly  Ala Asn Leu Ala Tyr  Pro Ala Gly Ser Thr  Gln Pro Ile 
    2330                 2335                 2340             


Arg Ile  Glu Pro Ser Ser Ser  Gln Val Ala Glu Gly  Gln Thr Leu 
    2345                 2350                 2355             


Asp Leu  Asn Cys Val Val Pro  Gly Gln Ser His Ala  Gln Val Thr 
    2360                 2365                 2370             


Trp His  Lys Arg Gly Gly Ser  Leu Pro Val Arg His  Gln Thr His 
    2375                 2380                 2385             


Gly Ser  Leu Leu Arg Leu Tyr  Gln Ala Ser Pro Ala  Asp Ser Gly 
    2390                 2395                 2400             


Glu Tyr  Val Cys Arg Val Leu  Gly Ser Ser Val Pro  Leu Glu Ala 
    2405                 2410                 2415             


Ser Val  Leu Val Thr Ile Glu  Pro Ala Gly Ser Val  Pro Ala Leu 
    2420                 2425                 2430             


Gly Val  Thr Pro Thr Val Arg  Ile Glu Ser Ser Ser  Ser Gln Val 
    2435                 2440                 2445             


Ala Glu  Gly Gln Thr Leu Asp  Leu Asn Cys Leu Val  Ala Gly Gln 
    2450                 2455                 2460             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro 
    2465                 2470                 2475             


Ala Arg  His Gln Val His Gly  Ser Arg Leu Arg Leu  Leu Gln Val 
    2480                 2485                 2490             


Thr Pro  Ala Asp Ser Gly Glu  Tyr Val Cys Arg Val  Val Gly Ser 
    2495                 2500                 2505             


Ser Gly  Thr Gln Glu Ala Ser  Val Leu Val Thr Ile  Gln Gln Arg 
    2510                 2515                 2520             


Leu Ser  Gly Ser His Ser Gln  Gly Val Ala Tyr Pro  Val Arg Ile 
    2525                 2530                 2535             


Glu Ser  Ser Ser Ala Ser Leu  Ala Asn Gly His Thr  Leu Asp Leu 
    2540                 2545                 2550             


Asn Cys  Leu Val Ala Ser Gln  Ala Pro His Thr Ile  Thr Trp Tyr 
    2555                 2560                 2565             


Lys Arg  Gly Gly Ser Leu Pro  Ser Arg His Gln Ile  Val Gly Ser 
    2570                 2575                 2580             


Arg Leu  Arg Ile Pro Gln Val  Thr Pro Ala Asp Ser  Gly Glu Tyr 
    2585                 2590                 2595             


Val Cys  His Val Ser Asn Gly  Ala Gly Ser Arg Glu  Thr Ser Leu 
    2600                 2605                 2610             


Ile Val  Thr Ile Gln Gly Ser  Gly Ser Ser His Val  Pro Ser Val 
    2615                 2620                 2625             


Ser Pro  Pro Ile Arg Ile Glu  Ser Ser Ser Pro Thr  Val Val Glu 
    2630                 2635                 2640             


Gly Gln  Thr Leu Asp Leu Asn  Cys Val Val Ala Arg  Gln Pro Gln 
    2645                 2650                 2655             


Ala Ile  Ile Thr Trp Tyr Lys  Arg Gly Gly Ser Leu  Pro Ser Arg 
    2660                 2665                 2670             


His Gln  Thr His Gly Ser His  Leu Arg Leu His Gln  Met Ser Val 
    2675                 2680                 2685             


Ala Asp  Ser Gly Glu Tyr Val  Cys Arg Ala Asn Asn  Asn Ile Asp 
    2690                 2695                 2700             


Ala Leu  Glu Ala Ser Ile Val  Ile Ser Val Ser Pro  Ser Ala Gly 
    2705                 2710                 2715             


Ser Pro  Ser Ala Pro Gly Ser  Ser Met Pro Ile Arg  Ile Glu Ser 
    2720                 2725                 2730             


Ser Ser  Ser His Val Ala Glu  Gly Glu Thr Leu Asp  Leu Asn Cys 
    2735                 2740                 2745             


Val Val  Pro Gly Gln Ala His  Ala Gln Val Thr Trp  His Lys Arg 
    2750                 2755                 2760             


Gly Gly  Ser Leu Pro Ser His  His Gln Thr Arg Gly  Ser Arg Leu 
    2765                 2770                 2775             


Arg Leu  His His Val Ser Pro  Ala Asp Ser Gly Glu  Tyr Val Cys 
    2780                 2785                 2790             


Arg Val  Met Gly Ser Ser Gly  Pro Leu Glu Ala Ser  Val Leu Val 
    2795                 2800                 2805             


Thr Ile  Glu Ala Ser Gly Ser  Ser Ala Val His Val  Pro Ala Pro 
    2810                 2815                 2820             


Gly Gly  Ala Pro Pro Ile Arg  Ile Glu Pro Ser Ser  Ser Arg Val 
    2825                 2830                 2835             


Ala Glu  Gly Gln Thr Leu Asp  Leu Lys Cys Val Val  Pro Gly Gln 
    2840                 2845                 2850             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Asn Leu Pro 
    2855                 2860                 2865             


Ala Arg  His Gln Val His Gly  Pro Leu Leu Arg Leu  Asn Gln Val 
    2870                 2875                 2880             


Ser Pro  Ala Asp Ser Gly Glu  Tyr Ser Cys Gln Val  Thr Gly Ser 
    2885                 2890                 2895             


Ser Gly  Thr Leu Glu Ala Ser  Val Leu Val Thr Ile  Glu Pro Ser 
    2900                 2905                 2910             


Ser Pro  Gly Pro Ile Pro Ala  Pro Gly Leu Ala Gln  Pro Ile Tyr 
    2915                 2920                 2925             


Ile Glu  Ala Ser Ser Ser His  Val Thr Glu Gly Gln  Thr Leu Asp 
    2930                 2935                 2940             


Leu Asn  Cys Val Val Pro Gly  Gln Ala His Ala Gln  Val Thr Trp 
    2945                 2950                 2955             


Tyr Lys  Arg Gly Gly Ser Leu  Pro Ala Arg His Gln  Thr His Gly 
    2960                 2965                 2970             


Ser Gln  Leu Arg Leu His Leu  Val Ser Pro Ala Asp  Ser Gly Glu 
    2975                 2980                 2985             


Tyr Val  Cys Arg Ala Ala Ser  Gly Pro Gly Pro Glu  Gln Glu Ala 
    2990                 2995                 3000             


Ser Phe  Thr Val Thr Val Pro  Pro Ser Glu Gly Ser  Ser Tyr Arg 
    3005                 3010                 3015             


Leu Arg  Ser Pro Val Ile Ser  Ile Asp Pro Pro Ser  Ser Thr Val 
    3020                 3025                 3030             


Gln Gln  Gly Gln Asp Ala Ser  Phe Lys Cys Leu Ile  His Asp Gly 
    3035                 3040                 3045             


Ala Ala  Pro Ile Ser Leu Glu  Trp Lys Thr Arg Asn  Gln Glu Leu 
    3050                 3055                 3060             


Glu Asp  Asn Val His Ile Ser  Pro Asn Gly Ser Ile  Ile Thr Ile 
    3065                 3070                 3075             


Val Gly  Thr Arg Pro Ser Asn  His Gly Thr Tyr Arg  Cys Val Ala 
    3080                 3085                 3090             


Ser Asn  Ala Tyr Gly Val Ala  Gln Ser Val Val Asn  Leu Ser Val 
    3095                 3100                 3105             


His Gly  Pro Pro Thr Val Ser  Val Leu Pro Glu Gly  Pro Val Trp 
    3110                 3115                 3120             


Val Lys  Val Gly Lys Ala Val  Thr Leu Glu Cys Val  Ser Ala Gly 
    3125                 3130                 3135             


Glu Pro  Arg Ser Ser Ala Arg  Trp Thr Arg Ile Ser  Ser Thr Pro 
    3140                 3145                 3150             


Ala Lys  Leu Glu Gln Arg Thr  Tyr Gly Leu Met Asp  Ser His Ala 
    3155                 3160                 3165             


Val Leu  Gln Ile Ser Ser Ala  Lys Pro Ser Asp Ala  Gly Thr Tyr 
    3170                 3175                 3180             


Val Cys  Leu Ala Gln Asn Ala  Leu Gly Thr Ala Gln  Lys Gln Val 
    3185                 3190                 3195             


Glu Val  Ile Val Asp Thr Gly  Ala Met Ala Pro Gly  Ala Pro Gln 
    3200                 3205                 3210             


Val Gln  Ala Glu Glu Ala Glu  Leu Thr Val Glu Ala  Gly His Thr 
    3215                 3220                 3225             


Ala Thr  Leu Arg Cys Ser Ala  Thr Gly Ser Pro Ala  Pro Thr Ile 
    3230                 3235                 3240             


His Trp  Ser Lys Leu Arg Ser  Pro Leu Pro Trp Gln  His Arg Leu 
    3245                 3250                 3255             


Glu Gly  Asp Thr Leu Ile Ile  Pro Arg Val Ala Gln  Gln Asp Ser 
    3260                 3265                 3270             


Gly Gln  Tyr Ile Cys Asn Ala  Thr Ser Pro Ala Gly  His Ala Glu 
    3275                 3280                 3285             


Ala Thr  Ile Ile Leu His Val  Glu Ser Pro Pro Tyr  Ala Thr Thr 
    3290                 3295                 3300             


Val Pro  Glu His Ala Ser Val  Gln Ala Gly Glu Thr  Val Gln Leu 
    3305                 3310                 3315             


Gln Cys  Leu Ala His Gly Thr  Pro Pro Leu Thr Phe  Gln Trp Ser 
    3320                 3325                 3330             


Arg Val  Gly Ser Ser Leu Pro  Gly Arg Ala Thr Ala  Arg Asn Glu 
    3335                 3340                 3345             


Leu Leu  His Phe Glu Arg Ala  Ala Pro Glu Asp Ser  Gly Arg Tyr 
    3350                 3355                 3360             


Arg Cys  Arg Val Thr Asn Lys  Val Gly Ser Ala Glu  Ala Phe Ala 
    3365                 3370                 3375             


Gln Leu  Leu Val Gln Gly Pro  Pro Gly Ser Leu Pro  Ala Thr Ser 
    3380                 3385                 3390             


Ile Pro  Ala Gly Ser Thr Pro  Thr Val Gln Val Thr  Pro Gln Leu 
    3395                 3400                 3405             


Glu Thr  Lys Ser Ile Gly Ala  Ser Val Glu Phe His  Cys Ala Val 
    3410                 3415                 3420             


Pro Ser  Asp Arg Gly Thr Gln  Leu Arg Trp Phe Lys  Glu Gly Gly 
    3425                 3430                 3435             


Gln Leu  Pro Pro Gly His Ser  Val Gln Asp Gly Val  Leu Arg Ile 
    3440                 3445                 3450             


Gln Asn  Leu Asp Gln Ser Cys  Gln Gly Thr Tyr Ile  Cys Gln Ala 
    3455                 3460                 3465             


His Gly  Pro Trp Gly Lys Ala  Gln Ala Ser Ala Gln  Leu Val Ile 
    3470                 3475                 3480             


Gln Ala  Leu Pro Ser Val Leu  Ile Asn Ile Arg Thr  Ser Val Gln 
    3485                 3490                 3495             


Thr Val  Val Val Gly His Ala  Val Glu Phe Glu Cys  Leu Ala Leu 
    3500                 3505                 3510             


Gly Asp  Pro Lys Pro Gln Val  Thr Trp Ser Lys Val  Gly Gly His 
    3515                 3520                 3525             


Leu Arg  Pro Gly Ile Val Gln  Ser Gly Gly Val Val  Arg Ile Ala 
    3530                 3535                 3540             


His Val  Glu Leu Ala Asp Ala  Gly Gln Tyr Arg Cys  Thr Ala Thr 
    3545                 3550                 3555             


Asn Ala  Ala Gly Thr Thr Gln  Ser His Val Leu Leu  Leu Val Gln 
    3560                 3565                 3570             


Ala Leu  Pro Gln Ile Ser Met  Pro Gln Glu Val Arg  Val Pro Ala 
    3575                 3580                 3585             


Gly Ser  Ala Ala Val Phe Pro  Cys Ile Ala Ser Gly  Tyr Pro Thr 
    3590                 3595                 3600             


Pro Asp  Ile Ser Trp Ser Lys  Leu Asp Gly Ser Leu  Pro Pro Asp 
    3605                 3610                 3615             


Ser Arg  Leu Glu Asn Asn Met  Leu Met Leu Pro Ser  Val Arg Pro 
    3620                 3625                 3630             


Gln Asp  Ala Gly Thr Tyr Val  Cys Thr Ala Thr Asn  Arg Gln Gly 
    3635                 3640                 3645             


Lys Val  Lys Ala Phe Ala His  Leu Gln Val Pro Glu  Arg Val Val 
    3650                 3655                 3660             


Pro Tyr  Phe Thr Gln Thr Pro  Tyr Ser Phe Leu Pro  Leu Pro Thr 
    3665                 3670                 3675             


Ile Lys  Asp Ala Tyr Arg Lys  Phe Glu Ile Lys Ile  Thr Phe Arg 
    3680                 3685                 3690             


Pro Asp  Ser Ala Asp Gly Met  Leu Leu Tyr Asn Gly  Gln Lys Arg 
    3695                 3700                 3705             


Val Pro  Gly Ser Pro Thr Asn  Leu Ala Asn Arg Gln  Pro Asp Phe 
    3710                 3715                 3720             


Ile Ser  Phe Gly Leu Val Gly  Gly Arg Pro Glu Phe  Arg Phe Asp 
    3725                 3730                 3735             


Ala Gly  Ser Gly Met Ala Thr  Ile Arg His Pro Thr  Pro Leu Ala 
    3740                 3745                 3750             


Leu Gly  His Phe His Thr Val  Thr Leu Leu Arg Ser  Leu Thr Gln 
    3755                 3760                 3765             


Gly Ser  Leu Ile Val Gly Asp  Leu Ala Pro Val Asn  Gly Thr Ser 
    3770                 3775                 3780             


Gln Gly  Lys Phe Gln Gly Leu  Asp Leu Asn Glu Glu  Leu Tyr Leu 
    3785                 3790                 3795             


Gly Gly  Tyr Pro Asp Tyr Gly  Ala Ile Pro Lys Ala  Gly Leu Ser 
    3800                 3805                 3810             


Ser Gly  Phe Ile Gly Cys Val  Arg Glu Leu Arg Ile  Gln Gly Glu 
    3815                 3820                 3825             


Glu Ile  Val Phe His Asp Leu  Asn Leu Thr Ala His  Gly Ile Ser 
    3830                 3835                 3840             


His Cys  Pro Thr Cys Arg Asp  Arg Pro Cys Gln Asn  Gly Gly Gln 
    3845                 3850                 3855             


Cys His  Asp Ser Glu Ser Ser  Ser Tyr Val Cys Val  Cys Pro Ala 
    3860                 3865                 3870             


Gly Phe  Thr Gly Ser Arg Cys  Glu His Ser Gln Ala  Leu His Cys 
    3875                 3880                 3885             


His Pro  Glu Ala Cys Gly Pro  Asp Ala Thr Cys Val  Asn Arg Pro 
    3890                 3895                 3900             


Asp Gly  Arg Gly Tyr Thr Cys  Arg Cys His Leu Gly  Arg Ser Gly 
    3905                 3910                 3915             


Leu Arg  Cys Glu Glu Gly Val  Thr Val Thr Thr Pro  Ser Leu Ser 
    3920                 3925                 3930             


Gly Ala  Gly Ser Tyr Leu Ala  Leu Pro Ala Leu Thr  Asn Thr His 
    3935                 3940                 3945             


His Glu  Leu Arg Leu Asp Val  Glu Phe Lys Pro Leu  Ala Pro Asp 
    3950                 3955                 3960             


Gly Val  Leu Leu Phe Ser Gly  Gly Lys Ser Gly Pro  Val Glu Asp 
    3965                 3970                 3975             


Phe Val  Ser Leu Ala Met Val  Gly Gly His Leu Glu  Phe Arg Tyr 
    3980                 3985                 3990             


Glu Leu  Gly Ser Gly Leu Ala  Val Leu Arg Ser Ala  Glu Pro Leu 
    3995                 4000                 4005             


Ala Leu  Gly Arg Trp His Arg  Val Ser Ala Glu Arg  Leu Asn Lys 
    4010                 4015                 4020             


Asp Gly  Ser Leu Arg Val Asn  Gly Gly Arg Pro Val  Leu Arg Ser 
    4025                 4030                 4035             


Ser Pro  Gly Lys Ser Gln Gly  Leu Asn Leu His Thr  Leu Leu Tyr 
    4040                 4045                 4050             


Leu Gly  Gly Val Glu Pro Ser  Val Pro Leu Ser Pro  Ala Thr Asn 
    4055                 4060                 4065             


Met Ser  Ala His Phe Arg Gly  Cys Val Gly Glu Val  Ser Val Asn 
    4070                 4075                 4080             


Gly Lys  Arg Leu Asp Leu Thr  Tyr Ser Phe Leu Gly  Ser Gln Gly 
    4085                 4090                 4095             


Ile Gly  Gln Cys Tyr Asp Ser  Ser Pro Cys Glu Arg  Gln Pro Cys 
    4100                 4105                 4110             


Gln His  Gly Ala Thr Cys Met  Pro Ala Gly Glu Tyr  Glu Phe Gln 
    4115                 4120                 4125             


Cys Leu  Cys Arg Asp Gly Phe  Lys Gly Asp Leu Cys  Glu His Glu 
    4130                 4135                 4140             


Glu Asn  Pro Cys Gln Leu Arg  Glu Pro Cys Leu His  Gly Gly Thr 
    4145                 4150                 4155             


Cys Gln  Gly Thr Arg Cys Leu  Cys Leu Pro Gly Phe  Ser Gly Pro 
    4160                 4165                 4170             


Arg Cys  Gln Gln Gly Ser Gly  His Gly Ile Ala Glu  Ser Asp Trp 
    4175                 4180                 4185             


His Leu  Glu Gly Ser Gly Gly  Asn Asp Ala Pro Gly  Gln Tyr Gly 
    4190                 4195                 4200             


Ala Tyr  Phe His Asp Asp Gly  Phe Leu Ala Phe Pro  Gly His Val 
    4205                 4210                 4215             


Phe Ser  Arg Ser Leu Pro Glu  Val Pro Glu Thr Ile  Glu Leu Glu 
    4220                 4225                 4230             


Val Arg  Thr Ser Thr Ala Ser  Gly Leu Leu Leu Trp  Gln Gly Val 
    4235                 4240                 4245             


Glu Val  Gly Glu Ala Gly Gln  Gly Lys Asp Phe Ile  Ser Leu Gly 
    4250                 4255                 4260             


Leu Gln  Asp Gly His Leu Val  Phe Arg Tyr Gln Leu  Gly Ser Gly 
    4265                 4270                 4275             


Glu Ala  Arg Leu Val Ser Glu  Asp Pro Ile Asn Asp  Gly Glu Trp 
    4280                 4285                 4290             


His Arg  Val Thr Ala Leu Arg  Glu Gly Arg Arg Gly  Ser Ile Gln 
    4295                 4300                 4305             


Val Asp  Gly Glu Glu Leu Val  Ser Gly Arg Ser Pro  Gly Pro Asn 
    4310                 4315                 4320             


Val Ala  Val Asn Ala Lys Gly  Ser Val Tyr Ile Gly  Gly Ala Pro 
    4325                 4330                 4335             


Asp Val  Ala Thr Leu Thr Gly  Gly Arg Phe Ser Ser  Gly Ile Thr 
    4340                 4345                 4350             


Gly Cys  Val Lys Asn Leu Val  Leu His Ser Ala Arg  Pro Gly Ala 
    4355                 4360                 4365             


Pro Pro  Pro Gln Pro Leu Asp  Leu Gln His Arg Ala  Gln Ala Gly 
    4370                 4375                 4380             


Ala Asn  Thr Arg Pro Cys Pro  Ser 
    4385                 4390     


<210>  3
<211>  4383
<212>  PRT
<213>  Mus musculus

<400>  3

Met Gly Gln Arg Ala Val Gly Ser Leu Leu Leu Gly Leu Leu Leu His 
1               5                   10                  15      


Ala Arg Leu Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu 
            20                  25                  30          


Ser Leu Pro Glu Asp Thr Glu Thr Val Thr Ala Ser Arg Tyr Gly Trp 
        35                  40                  45              


Thr Tyr Ser Tyr Leu Ser Asp Asp Glu Asp Leu Leu Ala Asp Asp Ala 
    50                  55                  60                  


Ser Gly Asp Gly Leu Gly Ser Gly Asp Val Gly Ser Gly Asp Phe Gln 
65                  70                  75                  80  


Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg Ser Ile Glu Tyr 
                85                  90                  95      


Ser Pro Gln Leu Glu Asp Ala Ser Ala Lys Glu Phe Arg Glu Val Ser 
            100                 105                 110         


Glu Ala Val Val Glu Lys Leu Glu Pro Glu Tyr Arg Lys Ile Pro Gly 
        115                 120                 125             


Asp Gln Ile Val Ser Val Val Phe Ile Lys Glu Leu Asp Gly Trp Val 
    130                 135                 140                 


Phe Val Glu Leu Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ser Gln 
145                 150                 155                 160 


Ile Gln Glu Val Leu His Thr Val Val Ser Ser Gly Ser Ile Gly Pro 
                165                 170                 175     


Tyr Val Thr Ser Pro Trp Gly Phe Lys Phe Arg Arg Leu Gly Thr Val 
            180                 185                 190         


Pro Gln Phe Pro Arg Val Cys Thr Glu Thr Glu Phe Ala Cys His Ser 
        195                 200                 205             


Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp Arg Arg Pro Asp 
    210                 215                 220                 


Cys Arg Asp Met Ser Asp Glu Leu Asn Cys Glu Glu Pro Val Pro Glu 
225                 230                 235                 240 


Leu Ser Ser Ser Thr Pro Ala Val Gly Lys Val Ser Pro Leu Pro Leu 
                245                 250                 255     


Trp Pro Glu Ala Ala Thr Thr Pro Pro Pro Pro Val Thr His Gly Pro 
            260                 265                 270         


Gln Phe Leu Leu Pro Ser Val Pro Gly Pro Ser Ala Cys Gly Pro Gln 
        275                 280                 285             


Glu Ala Ser Cys His Ser Gly His Cys Ile Pro Arg Asp Tyr Leu Cys 
    290                 295                 300                 


Asp Gly Gln Glu Asp Cys Arg Asp Gly Ser Asp Glu Leu Gly Cys Ala 
305                 310                 315                 320 


Ser Pro Pro Pro Cys Glu Pro Asn Glu Phe Ala Cys Glu Asn Gly His 
                325                 330                 335     


Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp Phe Asp Cys Glu Asp 
            340                 345                 350         


Arg Thr Asp Glu Ala Asn Cys Ser Val Lys Gln Pro Gly Glu Val Cys 
        355                 360                 365             


Gly Pro Thr His Phe Gln Cys Val Ser Thr Asn Arg Cys Ile Pro Ala 
    370                 375                 380                 


Ser Phe His Cys Asp Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu 
385                 390                 395                 400 


Phe Gly Cys Met Pro Pro Gln Val Val Thr Pro Pro Gln Gln Ser Ile 
                405                 410                 415     


Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Thr Gly 
            420                 425                 430         


Val Pro Thr Pro Ile Ile Asn Trp Arg Leu Asn Trp Gly His Ile Pro 
        435                 440                 445             


Ala His Pro Arg Val Thr Met Thr Ser Glu Gly Gly Arg Gly Thr Leu 
    450                 455                 460                 


Ile Ile Arg Asp Val Lys Glu Ala Asp Gln Gly Ala Tyr Thr Cys Glu 
465                 470                 475                 480 


Ala Met Asn Ser Arg Gly Met Val Phe Gly Ile Pro Asp Gly Val Leu 
                485                 490                 495     


Glu Leu Val Pro Gln Arg Gly Pro Cys Pro Asp Gly His Phe Tyr Leu 
            500                 505                 510         


Glu Asp Ser Ala Ser Cys Leu Pro Cys Phe Cys Phe Gly Val Thr Asn 
        515                 520                 525             


Val Cys Gln Ser Ser Leu Arg Phe Arg Asp Gln Ile Arg Leu Ser Phe 
    530                 535                 540                 


Asp Gln Pro Asn Asp Phe Lys Gly Val Asn Val Thr Met Pro Ser Gln 
545                 550                 555                 560 


Pro Gly Val Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp Pro Ala 
                565                 570                 575     


Leu Gln Glu Phe Gln Leu Val Asp Leu Ser Arg Arg Phe Leu Val His 
            580                 585                 590         


Asp Ala Phe Trp Ala Leu Pro Lys Gln Phe Leu Gly Asn Lys Val Asp 
        595                 600                 605             


Ser Tyr Gly Gly Phe Leu Arg Tyr Lys Val Arg Tyr Glu Leu Ala Arg 
    610                 615                 620                 


Gly Met Leu Glu Pro Val Gln Lys Pro Asp Val Ile Leu Val Gly Ala 
625                 630                 635                 640 


Gly Tyr Arg Leu His Ser Arg Gly His Thr Pro Thr His Pro Gly Thr 
                645                 650                 655     


Leu Asn Gln Arg Gln Val Gln Leu Ser Glu Glu His Trp Val His Glu 
            660                 665                 670         


Ser Gly Arg Pro Val Gln Arg Ala Glu Met Leu Gln Ala Leu Ala Ser 
        675                 680                 685             


Leu Glu Ala Val Leu Leu Gln Thr Val Tyr Asn Thr Lys Met Ala Ser 
    690                 695                 700                 


Val Gly Leu Ser Asp Ile Val Met Asp Thr Thr Val Thr His Thr Thr 
705                 710                 715                 720 


Ile His Gly Arg Ala His Ser Val Glu Glu Cys Arg Cys Pro Ile Gly 
                725                 730                 735     


Tyr Ser Gly Leu Ser Cys Glu Ser Cys Asp Ala His Phe Thr Arg Val 
            740                 745                 750         


Pro Gly Gly Pro Tyr Leu Gly Thr Cys Ser Gly Cys Asn Cys Asn Gly 
        755                 760                 765             


His Ala Ser Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn Cys Gln 
    770                 775                 780                 


His Asn Thr Glu Gly Pro Gln Cys Asp Lys Cys Lys Pro Gly Phe Phe 
785                 790                 795                 800 


Gly Asp Ala Thr Lys Ala Thr Ala Thr Ala Cys Arg Pro Cys Pro Cys 
                805                 810                 815     


Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys Phe Leu Asp 
            820                 825                 830         


Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala Pro Gly Tyr Thr Gly 
        835                 840                 845             


Arg Arg Cys Glu Ser Cys Ala Pro Gly Tyr Glu Gly Asn Pro Ile Gln 
    850                 855                 860                 


Pro Gly Gly Lys Cys Arg Pro Thr Thr Gln Glu Ile Val Arg Cys Asp 
865                 870                 875                 880 


Glu Arg Gly Ser Leu Gly Thr Ser Gly Glu Thr Cys Arg Cys Lys Asn 
                885                 890                 895     


Asn Val Val Gly Arg Leu Cys Asn Glu Cys Ser Asp Gly Ser Phe His 
            900                 905                 910         


Leu Ser Lys Gln Asn Pro Asp Gly Cys Leu Lys Cys Phe Cys Met Gly 
        915                 920                 925             


Val Ser Arg Gln Cys Ser Ser Ser Ser Trp Ser Arg Ala Gln Val Leu 
    930                 935                 940                 


Gly Ala Ser Glu Gln Pro Ser Gln Phe Ser Leu Ser Asn Ala Ala Gly 
945                 950                 955                 960 


Thr His Thr Thr Ser Glu Gly Val Ser Ser Pro Ala Pro Gly Glu Leu 
                965                 970                 975     


Ser Phe Ser Ser Phe His Asn Leu Leu Ser Glu Pro Tyr Phe Trp Ser 
            980                 985                 990         


Leu Pro Ala Ser Phe Arg Gly Asp  Lys Val Thr Ser Tyr  Gly Gly Glu 
        995                 1000                 1005             


Leu Arg  Phe Thr Val Thr Gln  Arg Pro Arg Pro Ser  Ser Ala Pro 
    1010                 1015                 1020             


Leu His  Arg Gln Pro Leu Val  Val Leu Gln Gly Asn  Asn Ile Val 
    1025                 1030                 1035             


Leu Glu  His His Ala Ser Arg  Asp Pro Ser Pro Gly  Gln Pro Ser 
    1040                 1045                 1050             


Asn Phe  Ile Val Pro Phe Gln  Glu Gln Ala Trp Gln  Arg Pro Asp 
    1055                 1060                 1065             


Gly Gln  Pro Ala Thr Arg Glu  His Leu Leu Met Ala  Leu Ala Gly 
    1070                 1075                 1080             


Ile Asp  Ala Leu Leu Ile Gln  Ala Ser Tyr Thr Gln  Gln Pro Ala 
    1085                 1090                 1095             


Glu Ser  Arg Val Ser Gly Ile  Ser Met Asp Val Ala  Val Pro Glu 
    1100                 1105                 1110             


Asn Thr  Gly Gln Asp Ser Ala  Arg Glu Val Glu Gln  Cys Thr Cys 
    1115                 1120                 1125             


Pro Pro  Gly Tyr Arg Gly Pro  Ser Cys Gln Asp Cys  Asp Thr Gly 
    1130                 1135                 1140             


Tyr Thr  Arg Val Pro Ser Gly  Leu Tyr Leu Gly Thr  Cys Glu Arg 
    1145                 1150                 1155             


Cys Asn  Cys His Gly His Ser  Glu Thr Cys Glu Pro  Glu Thr Gly 
    1160                 1165                 1170             


Ala Cys  Gln Ser Cys Gln His  His Thr Glu Gly Ala  Ser Cys Glu 
    1175                 1180                 1185             


Gln Cys  Gln Pro Gly Tyr Tyr  Gly Asp Ala Gln Arg  Gly Thr Pro 
    1190                 1195                 1200             


Gln Asp  Cys Gln Pro Cys Pro  Cys Tyr Gly Ala Pro  Ala Ala Gly 
    1205                 1210                 1215             


Gln Ala  Ala His Thr Cys Phe  Leu Asp Thr Asp Gly  His Pro Thr 
    1220                 1225                 1230             


Cys Asp  Ser Cys Ser Pro Gly  His Ser Gly Arg His  Cys Glu Arg 
    1235                 1240                 1245             


Cys Ala  Pro Gly Tyr Tyr Gly  Asn Pro Ser Gln Gly  Gln Pro Cys 
    1250                 1255                 1260             


His Arg  Asp Gly Gln Val Pro  Glu Val Leu Gly Cys  Gly Cys Asp 
    1265                 1270                 1275             


Pro His  Gly Ser Ile Ser Ser  Gln Cys Asp Ala Ala  Gly Gln Cys 
    1280                 1285                 1290             


Gln Cys  Lys Ala Gln Val Glu  Gly Arg Thr Cys Ser  His Cys Arg 
    1295                 1300                 1305             


Pro His  His Phe His Leu Ser  Ala Ser Asn Pro Glu  Gly Cys Leu 
    1310                 1315                 1320             


Pro Cys  Phe Cys Met Gly Val  Thr Gln Gln Cys Ala  Ser Ser Ser 
    1325                 1330                 1335             


Tyr Ser  Arg Gln Leu Ile Ser  Thr His Phe Ala Pro  Gly Asp Phe 
    1340                 1345                 1350             


Gln Gly  Phe Ala Leu Val Asn  Pro Gln Arg Asn Ser  Gln Leu Thr 
    1355                 1360                 1365             


Gly Gly  Phe Thr Val Glu Pro  Val His Asp Gly Ala  Arg Leu Ser 
    1370                 1375                 1380             


Phe Ser  Asn Phe Ala His Leu  Gly Gln Glu Ser Phe  Tyr Trp Gln 
    1385                 1390                 1395             


Leu Pro  Glu Ile Tyr Gln Gly  Asp Lys Val Ala Ala  Tyr Gly Gly 
    1400                 1405                 1410             


Lys Leu  Arg Tyr Thr Leu Ser  Tyr Thr Ala Gly Pro  Gln Gly Ser 
    1415                 1420                 1425             


Pro Leu  Leu Asp Pro Asp Ile  Gln Ile Thr Gly Asn  Asn Ile Met 
    1430                 1435                 1440             


Leu Val  Ala Ser Gln Pro Ala  Leu Gln Gly Pro Glu  Arg Arg Ser 
    1445                 1450                 1455             


Tyr Glu  Ile Ile Phe Arg Glu  Glu Phe Trp Arg Arg  Pro Asp Gly 
    1460                 1465                 1470             


Gln Pro  Ala Thr Arg Glu His  Leu Leu Met Ala Leu  Ala Asp Leu 
    1475                 1480                 1485             


Asp Glu  Leu Leu Val Arg Ala  Thr Phe Ser Ser Val  Pro Arg Ala 
    1490                 1495                 1500             


Ala Ser  Ile Ser Ala Val Ser  Leu Glu Val Ala Gln  Pro Gly Pro 
    1505                 1510                 1515             


Ser Ser  Gly Pro Arg Ala Leu  Glu Val Glu Glu Cys  Arg Cys Pro 
    1520                 1525                 1530             


Pro Gly  Tyr Val Gly Leu Ser  Cys Gln Asp Cys Ala  Pro Gly Tyr 
    1535                 1540                 1545             


Thr Arg  Thr Gly Ser Gly Leu  Tyr Leu Gly Gln Cys  Glu Leu Cys 
    1550                 1555                 1560             


Glu Cys  Asn Gly His Ser Asp  Leu Cys His Pro Glu  Thr Gly Ala 
    1565                 1570                 1575             


Cys Ser  Arg Cys Gln His Asn  Thr Ala Gly Glu Phe  Cys Glu Leu 
    1580                 1585                 1590             


Cys Ala  Thr Gly Tyr Tyr Gly  Asp Ala Thr Ala Gly  Thr Pro Glu 
    1595                 1600                 1605             


Asp Cys  Gln Pro Cys Ala Cys  Pro Leu Thr Asn Pro  Glu Asn Met 
    1610                 1615                 1620             


Phe Ser  Arg Thr Cys Glu Ser  Leu Gly Ala Gly Gly  Tyr Arg Cys 
    1625                 1630                 1635             


Thr Ala  Cys Glu Pro Gly Tyr  Thr Gly Gln Tyr Cys  Glu Gln Cys 
    1640                 1645                 1650             


Ala Pro  Gly Tyr Glu Gly Asp  Pro Asn Val Gln Gly  Gly Arg Cys 
    1655                 1660                 1665             


Gln Pro  Leu Thr Lys Glu Ser  Leu Glu Val Gln Ile  His Pro Ser 
    1670                 1675                 1680             


Arg Ser  Val Val Pro Gln Gly  Gly Pro His Ser Leu  Arg Cys Gln 
    1685                 1690                 1695             


Val Ser  Gly Ser Pro Pro His  Tyr Phe Tyr Trp Ser  Arg Glu Asp 
    1700                 1705                 1710             


Gly Arg  Pro Leu Pro Ser Ser  Ala Gln Gln Arg His  Gln Gly Ser 
    1715                 1720                 1725             


Glu Leu  His Phe Pro Ser Val  Gln Pro Ser Asp Ala  Gly Val Tyr 
    1730                 1735                 1740             


Ile Cys  Thr Cys Arg Asn Leu  Ile His Thr Ser Asn  Ser Arg Ala 
    1745                 1750                 1755             


Glu Leu  Leu Val Ala Glu Ala  Pro Ser Lys Pro Ile  Thr Val Thr 
    1760                 1765                 1770             


Val Glu  Glu Gln Arg Ser Gln  Ser Val Arg Pro Gly  Ala Asp Val 
    1775                 1780                 1785             


Thr Phe  Ile Cys Thr Ala Lys  Ser Lys Ser Pro Ala  Tyr Thr Leu 
    1790                 1795                 1800             


Val Trp  Thr Arg Leu His Asn  Gly Lys Leu Pro Ser  Arg Ala Met 
    1805                 1810                 1815             


Asp Phe  Asn Gly Ile Leu Thr  Ile Arg Asn Val Gln  Pro Ser Asp 
    1820                 1825                 1830             


Ala Gly  Thr Tyr Val Cys Thr  Gly Ser Asn Met Phe  Ala Met Asp 
    1835                 1840                 1845             


Gln Gly  Thr Ala Thr Leu His  Val Gln Val Ser Gly  Thr Ser Thr 
    1850                 1855                 1860             


Ala Pro  Val Ala Ser Ile His  Pro Pro Gln Leu Thr  Val Gln Pro 
    1865                 1870                 1875             


Gly Gln  Gln Ala Glu Phe Arg  Cys Ser Ala Thr Gly  Asn Pro Thr 
    1880                 1885                 1890             


Pro Met  Leu Glu Trp Ile Gly  Gly Pro Ser Gly Gln  Leu Pro Ala 
    1895                 1900                 1905             


Lys Ala  Gln Ile His Asn Gly  Ile Leu Arg Leu Pro  Ala Ile Glu 
    1910                 1915                 1920             


Pro Ser  Asp Gln Gly Gln Tyr  Leu Cys Arg Ala Leu  Ser Ser Ala 
    1925                 1930                 1935             


Gly Gln  His Val Ala Arg Ala  Met Leu Gln Val His  Gly Gly Ser 
    1940                 1945                 1950             


Gly Pro  Arg Val Gln Val Ser  Pro Glu Arg Thr Gln  Val His Glu 
    1955                 1960                 1965             


Gly Arg  Thr Val Arg Leu Tyr  Cys Arg Ala Ala Gly  Val Pro Ser 
    1970                 1975                 1980             


Ala Ser  Ile Thr Trp Arg Lys  Glu Gly Gly Ser Leu  Pro Pro Gln 
    1985                 1990                 1995             


Ala Arg  Ser Glu Asn Thr Asp  Ile Pro Thr Leu Leu  Ile Pro Ala 
    2000                 2005                 2010             


Ile Thr  Ala Ala Asp Ala Gly  Phe Tyr Leu Cys Val  Ala Thr Ser 
    2015                 2020                 2025             


Pro Thr  Gly Thr Ala Gln Ala  Arg Ile Gln Val Val  Val Leu Ser 
    2030                 2035                 2040             


Ala Ser  Gly Ala Asn Ser Val  Pro Val Arg Ile Glu  Ser Ser Ser 
    2045                 2050                 2055             


Pro Ser  Val Thr Glu Gly Gln  Thr Leu Asp Leu Asn  Cys Ala Val 
    2060                 2065                 2070             


Met Gly  Leu Thr Tyr Thr Gln  Val Thr Trp Tyr Lys  Arg Gly Gly 
    2075                 2080                 2085             


Ser Leu  Pro Pro His Ala Gln  Val His Gly Ser Arg  Leu Arg Leu 
    2090                 2095                 2100             


Pro Gln  Val Ser Pro Ala Asp  Ser Gly Asp Tyr Val  Cys Arg Val 
    2105                 2110                 2115             


Glu Ser  Asp Val Gly Pro Lys  Glu Ala Ser Ile Val  Val Ser Val 
    2120                 2125                 2130             


Leu His  Ser Pro His Ser Gly  Pro Ser Tyr Thr Pro  Ala Thr Ser 
    2135                 2140                 2145             


Ile Thr  Pro Pro Ile Arg Ile  Glu Ser Ser Ser Ser  His Val Ala 
    2150                 2155                 2160             


Glu Gly  Gln Thr Leu Asp Leu  Asn Cys Val Val Pro  Gly Gln Ala 
    2165                 2170                 2175             


Gln Val  Thr Trp Arg Lys Arg  Gly Gly Ser Leu Pro  Ala Arg His 
    2180                 2185                 2190             


Gln Thr  His Gly Ser Leu Leu  Arg Leu His Gln Val  Ser Pro Ala 
    2195                 2200                 2205             


Asp Ser  Gly Glu Tyr Val Cys  His Val Val Leu Gly  Ser Glu His 
    2210                 2215                 2220             


Thr Glu  Thr Ser Val Leu Val  Thr Ile Glu Pro Ala  Glu Ser Ile 
    2225                 2230                 2235             


Pro Ala  Pro Gly Pro Ala Pro  Pro Val Arg Ile Glu  Ala Ser Ser 
    2240                 2245                 2250             


Ser Thr  Val Thr Glu Gly His  Met Leu Asp Leu Asn  Cys Val Val 
    2255                 2260                 2265             


Ala Gly  Gln Ala His Ala Gln  Val Thr Trp Tyr Lys  Arg Gly Gly 
    2270                 2275                 2280             


Ser Leu  Pro Ala Arg His Gln  Val Arg Gly Ser Arg  Leu Tyr Ile 
    2285                 2290                 2295             


Leu Gln  Ala Ser Pro Ala Asp  Ala Gly Glu Tyr Val  Cys Arg Ala 
    2300                 2305                 2310             


Gly Asn  Gly Gln Glu Ala Thr  Ile Thr Val Thr Val  Thr Arg Asn 
    2315                 2320                 2325             


His Gly  Ala Asn Leu Ala Tyr  Pro Pro Gly Ser Thr  Ser Pro Ile 
    2330                 2335                 2340             


Arg Ile  Glu Ser Ser Ser Ser  His Val Ala Glu Gly  Gln Thr Leu 
    2345                 2350                 2355             


Asp Leu  Asn Cys Val Val Gln  Gly Gln Ala His Ala  Gln Val Thr 
    2360                 2365                 2370             


Trp His  Lys Arg Gly Gly Ser  Leu Pro Ala Arg His  Gln Thr His 
    2375                 2380                 2385             


Gly Ser  Leu Leu Arg Leu His  Gln Val Ser Pro Val  Asp Ser Gly 
    2390                 2395                 2400             


Glu Tyr  Val Cys Arg Val Glu  Gly Gly Ala Val Pro  Leu Glu Ser 
    2405                 2410                 2415             


Ser Val  Leu Val Thr Ile Glu  Pro Ala Gly Thr Ala  Pro Gly Val 
    2420                 2425                 2430             


Ile Pro  Pro Val Arg Ile Glu  Ser Ser Ser Ser His  Val Ser Glu 
    2435                 2440                 2445             


Gly Gln  Ser Leu Asp Leu Asn  Cys Leu Val Ser Gly  Gln Thr His 
    2450                 2455                 2460             


Pro Gln  Ile Ser Trp His Lys  Arg Gly Gly Ser Leu  Pro Ala Arg 
    2465                 2470                 2475             


His Gln  Val His Gly Ser Arg  Leu Arg Leu Leu Gln  Val Thr Pro 
    2480                 2485                 2490             


Thr Asp  Ser Gly Glu Tyr Val  Cys Arg Val Val Ser  Gly Ser Gly 
    2495                 2500                 2505             


Thr Gln  Glu Ala Ser Ile Leu  Val Thr Ile Gln Gln  Thr Leu Ser 
    2510                 2515                 2520             


Pro Ser  His Ser Gln Ser Val  Val His Pro Val Arg  Ile Glu Ser 
    2525                 2530                 2535             


Ser Ser  Pro Ser Leu Ala Asn  Gly His Thr Leu Asp  Leu Asn Cys 
    2540                 2545                 2550             


Leu Val  Ala Ser Leu Thr Pro  His Thr Ile Thr Trp  Tyr Lys Arg 
    2555                 2560                 2565             


Gly Gly  Ser Leu Pro Ser Arg  His Gln Ile Val Gly  Ser Arg Leu 
    2570                 2575                 2580             


Arg Ile  Pro Gln Val Thr Pro  Ala Asp Ser Gly Glu  Tyr Val Cys 
    2585                 2590                 2595             


His Val  Ser Asn Gly Ala Gly  Ser Gln Glu Thr Ser  Leu Ile Val 
    2600                 2605                 2610             


Thr Ile  Glu Ser Arg Gly Pro  Ser His Val Pro Ser  Val Ser Pro 
    2615                 2620                 2625             


Pro Met  Arg Ile Glu Thr Ser  Ser Pro Thr Val Thr  Glu Gly Gln 
    2630                 2635                 2640             


Thr Leu  Asp Leu Asn Cys Val  Val Val Gly Arg Pro  Gln Ala Thr 
    2645                 2650                 2655             


Ile Thr  Trp Tyr Lys Arg Gly  Gly Ser Leu Pro Phe  Arg His Gln 
    2660                 2665                 2670             


Ala His  Gly Ser Arg Leu Arg  Leu His His Met Ser  Val Ala Asp 
    2675                 2680                 2685             


Ser Gly  Glu Tyr Val Cys Arg  Ala Asn Asn Asn Ile  Asp Ala Gln 
    2690                 2695                 2700             


Glu Thr  Ser Ile Met Ile Ser  Val Ser Pro Ser Thr  Asn Ser Pro 
    2705                 2710                 2715             


Pro Ala  Pro Ala Ser Pro Ala  Pro Ile Arg Ile Glu  Ser Ser Ser 
    2720                 2725                 2730             


Ser Arg  Val Ala Glu Gly Gln  Thr Leu Asp Leu Asn  Cys Val Val 
    2735                 2740                 2745             


Pro Gly  His Ala His Ala Gln  Val Thr Trp His Lys  Arg Gly Gly 
    2750                 2755                 2760             


Ser Leu  Pro Thr His His Gln  Thr His Gly Ser Arg  Leu Arg Leu 
    2765                 2770                 2775             


Tyr Gln  Val Ser Ser Ala Asp  Ser Gly Glu Tyr Val  Cys Ser Val 
    2780                 2785                 2790             


Leu Ser  Ser Ser Gly Pro Leu  Glu Ala Ser Val Leu  Val Ser Ile 
    2795                 2800                 2805             


Thr Pro  Ala Ala Ala Asn Val  His Ile Pro Gly Glu  Val Pro Phe 
    2810                 2815                 2820             


Pro Pro  Ile Arg Ile Glu Thr  Ser Ser Ser Arg Val  Ala Glu Gly 
    2825                 2830                 2835             


Gln Thr  Leu Asp Leu Ser Cys  Val Val Pro Gly Gln  Ala His Ala 
    2840                 2845                 2850             


Gln Val  Thr Trp His Lys Arg  Gly Gly Ser Leu Pro  Ala Gly His 
    2855                 2860                 2865             


Gln Val  His Gly His Met Leu  Arg Leu Asn Arg Val  Ser Pro Ala 
    2870                 2875                 2880             


Asp Ser  Gly Glu Tyr Ser Cys  Gln Val Thr Gly Ser  Ser Gly Thr 
    2885                 2890                 2895             


Leu Glu  Ala Ser Val Leu Val  Thr Ile Glu Ala Ser  Glu Pro Ser 
    2900                 2905                 2910             


Pro Ile  Pro Ala Pro Gly Leu  Ala Gln Pro Val Tyr  Ile Glu Ser 
    2915                 2920                 2925             


Ser Ser  Ser His Leu Thr Glu  Gly Gln Thr Val Asp  Leu Lys Cys 
    2930                 2935                 2940             


Val Val  Pro Gly Gln Ala His  Ala Gln Val Thr Trp  His Lys Arg 
    2945                 2950                 2955             


Gly Ser  Ser Leu Pro Ala Arg  His Gln Thr His Gly  Ser Leu Leu 
    2960                 2965                 2970             


Arg Leu  Tyr Gln Leu Ser Pro  Ala Asp Ser Gly Glu  Tyr Val Cys 
    2975                 2980                 2985             


Gln Val  Ala Gly Ser Ser His  Pro Glu His Glu Ala  Ser Phe Lys 
    2990                 2995                 3000             


Leu Thr  Val Pro Ser Ser Gln  Asn Ser Ser Phe Arg  Leu Arg Ser 
    3005                 3010                 3015             


Pro Val  Ile Ser Ile Glu Pro  Pro Ser Ser Thr Val  Gln Gln Gly 
    3020                 3025                 3030             


Gln Asp  Ala Ser Phe Lys Cys  Leu Ile His Glu Gly  Ala Thr Pro 
    3035                 3040                 3045             


Ile Lys  Val Glu Trp Lys Ile  Arg Asp Gln Glu Leu  Glu Asp Asn 
    3050                 3055                 3060             


Val His  Ile Ser Pro Asn Gly  Ser Ile Ile Thr Ile  Val Gly Thr 
    3065                 3070                 3075             


Arg Pro  Ser Asn His Gly Ala  Tyr Arg Cys Val Ala  Ser Asn Val 
    3080                 3085                 3090             


Tyr Gly  Met Ala Gln Ser Val  Val Asn Leu Ser Val  His Gly Pro 
    3095                 3100                 3105             


Pro Thr  Val Ser Val Leu Pro  Glu Gly Pro Val His  Val Lys Met 
    3110                 3115                 3120             


Gly Lys  Asp Ile Thr Leu Glu  Cys Ile Ser Ser Gly  Glu Pro Arg 
    3125                 3130                 3135             


Ser Ser  Pro Arg Trp Thr Arg  Leu Gly Ile Pro Val  Lys Leu Glu 
    3140                 3145                 3150             


Pro Arg  Met Phe Gly Leu Met  Asn Ser His Ala Met  Leu Lys Ile 
    3155                 3160                 3165             


Ala Ser  Val Lys Pro Ser Asp  Ala Gly Thr Tyr Val  Cys Gln Ala 
    3170                 3175                 3180             


Gln Asn  Ala Leu Gly Thr Ala  Gln Lys Gln Val Glu  Leu Ile Val 
    3185                 3190                 3195             


Asp Thr  Gly Thr Val Ala Pro  Gly Ala Pro Gln Val  Gln Val Glu 
    3200                 3205                 3210             


Glu Ser  Glu Leu Thr Leu Glu  Ala Gly His Thr Ala  Thr Leu His 
    3215                 3220                 3225             


Cys Ser  Ala Thr Gly Asn Pro  Pro Pro Thr Ile His  Trp Ser Lys 
    3230                 3235                 3240             


Leu Arg  Ala Pro Leu Pro Trp  Gln His Arg Ile Glu  Gly Asn Thr 
    3245                 3250                 3255             


Leu Val  Ile Pro Arg Val Ala  Gln Gln Asp Ser Gly  Gln Tyr Ile 
    3260                 3265                 3270             


Cys Asn  Ala Thr Asn Ser Ala  Gly His Thr Glu Ala  Thr Val Val 
    3275                 3280                 3285             


Leu His  Val Glu Ser Pro Pro  Tyr Ala Thr Ile Ile  Pro Glu His 
    3290                 3295                 3300             


Thr Ser  Ala Gln Pro Gly Asn  Leu Val Gln Leu Gln  Cys Leu Ala 
    3305                 3310                 3315             


His Gly  Thr Pro Pro Leu Thr  Tyr Gln Trp Ser Leu  Val Gly Gly 
    3320                 3325                 3330             


Val Leu  Pro Glu Lys Ala Val  Ala Arg Asn Gln Val  Leu Arg Leu 
    3335                 3340                 3345             


Glu Pro  Thr Val Pro Glu Asp  Ser Gly Arg Tyr Arg  Cys Gln Val 
    3350                 3355                 3360             


Ser Asn  Arg Val Gly Ser Ala  Glu Ala Phe Ala Gln  Val Leu Val 
    3365                 3370                 3375             


Gln Gly  Ser Ser Ser Asn Leu  Pro Asp Thr Ser Ile  Pro Gly Gly 
    3380                 3385                 3390             


Ser Thr  Pro Thr Val Gln Val  Thr Pro Gln Leu Glu  Thr Arg Asn 
    3395                 3400                 3405             


Ile Gly  Ala Ser Val Glu Phe  His Cys Ala Val Pro  Asn Glu Arg 
    3410                 3415                 3420             


Gly Thr  His Leu Arg Trp Leu  Lys Glu Gly Gly Gln  Leu Pro Pro 
    3425                 3430                 3435             


Gly His  Ser Val Gln Asp Gly  Val Leu Arg Ile Gln  Asn Leu Asp 
    3440                 3445                 3450             


Gln Ser  Cys Gln Gly Thr Tyr  Val Cys Gln Ala His  Gly Pro Trp 
    3455                 3460                 3465             


Gly Gln  Ala Gln Ala Thr Ala  Gln Leu Ile Val Gln  Ala Leu Pro 
    3470                 3475                 3480             


Ser Val  Leu Ile Asn Val Arg  Thr Ser Val His Ser  Val Val Val 
    3485                 3490                 3495             


Gly His  Ser Val Glu Phe Glu  Cys Leu Ala Leu Gly  Asp Pro Lys 
    3500                 3505                 3510             


Pro Gln  Val Thr Trp Ser Lys  Val Gly Gly His Leu  Arg Pro Gly 
    3515                 3520                 3525             


Ile Val  Gln Ser Gly Ser Ile  Ile Arg Ile Ala His  Val Glu Leu 
    3530                 3535                 3540             


Ala Asp  Ala Gly Gln Tyr Arg  Cys Ala Ala Thr Asn  Ala Ala Gly 
    3545                 3550                 3555             


Thr Thr  Gln Ser His Val Leu  Leu Leu Val Gln Ala  Leu Pro Gln 
    3560                 3565                 3570             


Ile Ser  Thr Pro Pro Glu Ile  Arg Val Pro Ala Gly  Ser Ala Ala 
    3575                 3580                 3585             


Val Phe  Pro Cys Met Ala Ser  Gly Tyr Pro Thr Pro  Ala Ile Thr 
    3590                 3595                 3600             


Trp Ser  Lys Val Asp Gly Asp  Leu Pro Pro Asp Ser  Arg Leu Glu 
    3605                 3610                 3615             


Asn Asn  Met Leu Met Leu Pro  Ser Val Arg Pro Glu  Asp Ala Gly 
    3620                 3625                 3630             


Thr Tyr  Val Cys Thr Ala Thr  Asn Arg Gln Gly Lys  Val Lys Ala 
    3635                 3640                 3645             


Phe Ala  Tyr Leu Gln Val Pro  Glu Arg Val Ile Pro  Tyr Phe Thr 
    3650                 3655                 3660             


Gln Thr  Pro Tyr Ser Phe Leu  Pro Leu Pro Thr Ile  Lys Asp Ala 
    3665                 3670                 3675             


Tyr Arg  Lys Phe Glu Ile Lys  Ile Thr Phe Arg Pro  Asp Ser Ala 
    3680                 3685                 3690             


Asp Gly  Met Leu Leu Tyr Asn  Gly Gln Lys Arg Ser  Pro Thr Asn 
    3695                 3700                 3705             


Leu Ala  Asn Arg Gln Pro Asp  Phe Ile Ser Phe Gly  Leu Val Gly 
    3710                 3715                 3720             


Gly Arg  Pro Glu Phe Arg Phe  Asp Ala Gly Ser Gly  Met Ala Thr 
    3725                 3730                 3735             


Ile Arg  His Pro Thr Pro Leu  Ala Leu Gly Gln Phe  His Thr Val 
    3740                 3745                 3750             


Thr Leu  Leu Arg Ser Leu Thr  Gln Gly Ser Leu Ile  Val Gly Asn 
    3755                 3760                 3765             


Leu Ala  Pro Val Asn Gly Thr  Ser Gln Gly Lys Phe  Gln Gly Leu 
    3770                 3775                 3780             


Asp Leu  Asn Glu Glu Leu Tyr  Leu Gly Gly Tyr Pro  Asp Tyr Gly 
    3785                 3790                 3795             


Ala Ile  Pro Lys Ala Gly Leu  Ser Ser Gly Phe Val  Gly Cys Val 
    3800                 3805                 3810             


Arg Glu  Leu Arg Ile Gln Gly  Glu Glu Val Val Phe  His Asp Val 
    3815                 3820                 3825             


Asn Leu  Thr Thr His Gly Ile  Ser His Cys Pro Thr  Cys Gln Asp 
    3830                 3835                 3840             


Arg Pro  Cys Gln Asn Gly Gly  Gln Cys Gln Asp Ser  Glu Ser Ser 
    3845                 3850                 3855             


Ser Tyr  Thr Cys Val Cys Pro  Ala Gly Phe Thr Gly  Ser Arg Cys 
    3860                 3865                 3870             


Glu His  Ser Gln Ala Leu His  Cys His Pro Glu Ala  Cys Gly Pro 
    3875                 3880                 3885             


Asp Ala  Thr Cys Val Asn Arg  Pro Asp Gly Arg Gly  Tyr Thr Cys 
    3890                 3895                 3900             


Arg Cys  His Leu Gly Arg Ser  Gly Val Arg Cys Glu  Glu Gly Val 
    3905                 3910                 3915             


Thr Val  Thr Thr Pro Ser Met  Ser Gly Ala Gly Ser  Tyr Leu Ala 
    3920                 3925                 3930             


Leu Pro  Ala Leu Thr Asn Met  His His Glu Leu Arg  Leu Asp Val 
    3935                 3940                 3945             


Glu Phe  Lys Pro Leu Glu Pro  Asn Gly Ile Leu Leu  Phe Ser Gly 
    3950                 3955                 3960             


Gly Lys  Ser Gly Pro Val Glu  Asp Phe Val Ser Leu  Ala Met Val 
    3965                 3970                 3975             


Gly Gly  His Leu Glu Phe Arg  Tyr Glu Leu Gly Ser  Gly Leu Ala 
    3980                 3985                 3990             


Val Leu  Arg Ser His Glu Pro  Leu Thr Leu Gly Arg  Trp His Arg 
    3995                 4000                 4005             


Val Ser  Ala Glu Arg Leu Asn  Lys Asp Gly Ser Leu  Arg Val Asp 
    4010                 4015                 4020             


Gly Gly  Arg Pro Val Leu Arg  Ser Ser Pro Gly Lys  Ser Gln Gly 
    4025                 4030                 4035             


Leu Asn  Leu His Thr Leu Leu  Tyr Leu Gly Gly Val  Glu Pro Ser 
    4040                 4045                 4050             


Val Gln  Leu Ser Pro Ala Thr  Asn Met Ser Ala His  Phe His Gly 
    4055                 4060                 4065             


Cys Val  Gly Glu Val Ser Val  Asn Gly Lys Arg Leu  Asp Leu Thr 
    4070                 4075                 4080             


Tyr Ser  Phe Leu Gly Ser Gln  Gly Val Gly Gln Cys  Tyr Asp Ser 
    4085                 4090                 4095             


Ser Pro  Cys Glu Arg Gln Pro  Cys Gln Asn Gly Ala  Thr Cys Met 
    4100                 4105                 4110             


Pro Ala  Gly Glu Tyr Glu Phe  Gln Cys Leu Cys Gln  Asp Gly Phe 
    4115                 4120                 4125             


Lys Gly  Asp Leu Cys Glu His  Glu Glu Asn Pro Cys  Gln Leu His 
    4130                 4135                 4140             


Glu Pro  Cys Leu Asn Gly Gly  Thr Cys Arg Gly Ala  Arg Cys Leu 
    4145                 4150                 4155             


Cys Leu  Pro Gly Phe Ser Gly  Pro Arg Cys Gln Gln  Gly Ala Gly 
    4160                 4165                 4170             


Tyr Gly  Val Val Glu Ser Asp  Trp His Pro Glu Gly  Ser Gly Gly 
    4175                 4180                 4185             


Asn Asp  Ala Pro Gly Gln Tyr  Gly Ala Tyr Phe Tyr  Asp Asn Gly 
    4190                 4195                 4200             


Phe Leu  Gly Leu Pro Gly Asn  Ser Phe Ser Arg Ser  Leu Pro Glu 
    4205                 4210                 4215             


Val Pro  Glu Thr Ile Glu Phe  Glu Val Arg Thr Ser  Thr Ala Asp 
    4220                 4225                 4230             


Gly Leu  Leu Leu Trp Gln Gly  Val Val Arg Glu Ala  Ser Arg Ser 
    4235                 4240                 4245             


Lys Asp  Phe Ile Ser Leu Gly  Leu Gln Asp Gly His  Leu Val Phe 
    4250                 4255                 4260             


Ser Tyr  Gln Leu Gly Ser Gly  Glu Ala Arg Leu Val  Ser Glu Asp 
    4265                 4270                 4275             


Pro Ile  Asn Asp Gly Glu Trp  His Arg Ile Thr Ala  Leu Arg Glu 
    4280                 4285                 4290             


Gly Gln  Arg Gly Ser Ile Gln  Val Asp Gly Glu Asp  Leu Val Thr 
    4295                 4300                 4305             


Gly Arg  Ser Pro Gly Pro Asn  Val Ala Val Asn Thr  Lys Asp Ile 
    4310                 4315                 4320             


Ile Tyr  Ile Gly Gly Ala Pro  Asp Val Ala Thr Leu  Thr Arg Gly 
    4325                 4330                 4335             


Lys Phe  Ser Ser Gly Ile Thr  Gly Cys Ile Lys Asn  Leu Val Leu 
    4340                 4345                 4350             


His Thr  Ala Arg Pro Gly Ala  Pro Pro Pro Gln Pro  Leu Asp Leu 
    4355                 4360                 4365             


Gln His  Arg Ala Gln Ala Gly  Ala Asn Thr Arg Pro  Cys Pro Ser 
    4370                 4375                 4380             


<210>  4
<211>  2068
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Lys Ser Arg Lys  Val Pro His 
    1745                 1750                 1755             


Thr Val  Leu Asn Leu Lys Glu  Pro Leu Tyr Val Gly  Gly Ala Pro 
    1760                 1765                 1770             


Asp Phe  Ser Lys Leu Ala Arg  Ala Ala Ala Val Ser  Ser Gly Phe 
    1775                 1780                 1785             


Asp Gly  Ala Ile Gln Leu Val  Ser Leu Gly Gly Arg  Gln Leu Leu 
    1790                 1795                 1800             


Thr Pro  Glu His Val Leu Arg  Gln Val Asp Val Thr  Ser Phe Ala 
    1805                 1810                 1815             


Gly His  Pro Cys Thr Arg Ala  Ser Gly His Pro Cys  Leu Asn Gly 
    1820                 1825                 1830             


Ala Ser  Cys Val Pro Arg Glu  Ala Ala Tyr Val Cys  Leu Cys Pro 
    1835                 1840                 1845             


Gly Gly  Phe Ser Gly Pro His  Cys Glu Lys Gly Leu  Val Glu Lys 
    1850                 1855                 1860             


Ser Ala  Gly Asp Val Asp Thr  Leu Ala Phe Asp Gly  Arg Thr Phe 
    1865                 1870                 1875             


Val Glu  Tyr Leu Asn Ala Val  Thr Glu Ser Glu Leu  Ala Asn Glu 
    1880                 1885                 1890             


Ile Pro  Val Pro Glu Thr Leu  Asp Ser Gly Ala Leu  His Ser Glu 
    1895                 1900                 1905             


Lys Ala  Leu Gln Ser Asn His  Phe Glu Leu Ser Leu  Arg Thr Glu 
    1910                 1915                 1920             


Ala Thr  Gln Gly Leu Val Leu  Trp Ser Gly Lys Ala  Thr Glu Arg 
    1925                 1930                 1935             


Ala Asp  Tyr Val Ala Leu Ala  Ile Val Asp Gly His  Leu Gln Leu 
    1940                 1945                 1950             


Ser Tyr  Asn Leu Gly Ser Gln  Pro Val Val Leu Arg  Ser Thr Val 
    1955                 1960                 1965             


Pro Val  Asn Thr Asn Arg Trp  Leu Arg Val Val Ala  His Arg Glu 
    1970                 1975                 1980             


Gln Arg  Glu Gly Ser Leu Gln  Val Gly Asn Glu Ala  Pro Val Thr 
    1985                 1990                 1995             


Gly Ser  Ser Pro Leu Gly Ala  Thr Gln Leu Asp Thr  Asp Gly Ala 
    2000                 2005                 2010             


Leu Trp  Leu Gly Gly Leu Pro  Glu Leu Pro Val Gly  Pro Ala Leu 
    2015                 2020                 2025             


Pro Lys  Ala Tyr Gly Thr Gly  Phe Val Gly Cys Leu  Arg Asp Val 
    2030                 2035                 2040             


Val Val  Gly Arg His Pro Leu  His Leu Leu Glu Asp  Ala Val Thr 
    2045                 2050                 2055             


Lys Pro  Glu Leu Arg Pro Cys  Pro Thr Pro 
    2060                 2065             


<210>  5
<211>  2045
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro 
            20                  25                  30          


Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr 
        35                  40                  45              


Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr 
    50                  55                  60                  


Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val 
65                  70                  75                  80  


Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly 
                85                  90                  95      


Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr 
            100                 105                 110         


Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His 
        115                 120                 125             


Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg 
    130                 135                 140                 


Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His 
145                 150                 155                 160 


Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu 
                165                 170                 175     


Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg 
            180                 185                 190         


Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro 
        195                 200                 205             


Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln 
    210                 215                 220                 


Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly 
225                 230                 235                 240 


Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly 
                245                 250                 255     


Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys 
            260                 265                 270         


Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp 
        275                 280                 285             


Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala 
    290                 295                 300                 


Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys 
305                 310                 315                 320 


Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg 
                325                 330                 335     


Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg 
            340                 345                 350         


Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys 
        355                 360                 365             


Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val 
    370                 375                 380                 


Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg 
385                 390                 395                 400 


Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys 
                405                 410                 415     


Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp 
            420                 425                 430         


Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg 
        435                 440                 445             


Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala 
    450                 455                 460                 


Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala 
465                 470                 475                 480 


Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser 
                485                 490                 495     


Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala 
            500                 505                 510         


Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val 
        515                 520                 525             


Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala 
    530                 535                 540                 


Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val 
545                 550                 555                 560 


Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser 
                565                 570                 575     


Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His 
            580                 585                 590         


Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala 
        595                 600                 605             


Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu 
    610                 615                 620                 


His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
625                 630                 635                 640 


Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile 
                645                 650                 655     


Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly 
            660                 665                 670         


Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg 
        675                 680                 685             


Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val 
    690                 695                 700                 


Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser 
705                 710                 715                 720 


Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys 
                725                 730                 735     


Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly 
            740                 745                 750         


Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln 
        755                 760                 765             


Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val 
    770                 775                 780                 


Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser 
785                 790                 795                 800 


Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro 
                805                 810                 815     


Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn 
            820                 825                 830         


Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser 
        835                 840                 845             


Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly 
    850                 855                 860                 


Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys 
865                 870                 875                 880 


Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser 
                885                 890                 895     


Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys 
            900                 905                 910         


Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys 
        915                 920                 925             


Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr 
    930                 935                 940                 


Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln 
945                 950                 955                 960 


Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser 
                965                 970                 975     


Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu 
            980                 985                 990         


Leu Ser Gln Ala Leu Pro Ala Pro  Pro Gly Ala Leu Pro  Leu Ala Pro 
        995                 1000                 1005             


Ser Ser  Thr Ala His Ser Gln  Thr Thr Pro Pro Pro  Ser Ser Arg 
    1010                 1015                 1020             


Pro Arg  Thr Thr Ala Ser Val  Pro Arg Thr Thr Val  Trp Pro Val 
    1025                 1030                 1035             


Leu Thr  Val Pro Pro Thr Ala  Pro Ser Pro Ala Pro  Ser Leu Val 
    1040                 1045                 1050             


Ala Ser  Ala Phe Gly Glu Ser  Gly Ser Thr Asp Gly  Ser Ser Asp 
    1055                 1060                 1065             


Glu Glu  Leu Ser Gly Asp Gln  Glu Ala Ser Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Gly Leu  Glu Pro Leu Glu Gly  Ser Ser Val Ala Thr  Pro Gly Pro 
    1085                 1090                 1095             


Pro Val  Glu Arg Ala Ser Cys  Tyr Asn Ser Ala Leu  Gly Cys Cys 
    1100                 1105                 1110             


Ser Asp  Gly Lys Thr Pro Ser  Leu Asp Ala Glu Gly  Ser Asn Cys 
    1115                 1120                 1125             


Pro Ala  Thr Lys Val Phe Gln  Gly Val Leu Glu Leu  Glu Gly Val 
    1130                 1135                 1140             


Glu Gly  Gln Glu Leu Phe Tyr  Thr Pro Glu Met Ala  Asp Pro Lys 
    1145                 1150                 1155             


Ser Glu  Leu Phe Gly Glu Thr  Ala Arg Ser Ile Glu  Ser Thr Leu 
    1160                 1165                 1170             


Asp Asp  Leu Phe Arg Asn Ser  Asp Val Lys Lys Asp  Phe Arg Ser 
    1175                 1180                 1185             


Val Arg  Leu Arg Asp Leu Gly  Pro Gly Lys Ser Val  Arg Ala Ile 
    1190                 1195                 1200             


Val Asp  Val His Phe Asp Pro  Thr Thr Ala Phe Arg  Ala Pro Asp 
    1205                 1210                 1215             


Val Ala  Arg Ala Leu Leu Arg  Gln Ile Gln Val Ser  Arg Arg Arg 
    1220                 1225                 1230             


Ser Leu  Gly Val Arg Arg Pro  Leu Gln Glu His Val  Arg Phe Met 
    1235                 1240                 1245             


Asp Phe  Asp Trp Phe Pro Ala  Phe Ile Thr Gly Ala  Thr Ser Gly 
    1250                 1255                 1260             


Ala Ile  Ala Ala Gly Ala Thr  Ala Arg Ala Thr Thr  Ala Ser Arg 
    1265                 1270                 1275             


Leu Pro  Ser Ser Ala Val Thr  Pro Arg Ala Pro His  Pro Ser His 
    1280                 1285                 1290             


Thr Ser  Gln Pro Val Ala Lys  Thr Thr Ala Ala Pro  Thr Thr Arg 
    1295                 1300                 1305             


Arg Pro  Pro Thr Thr Ala Pro  Ser Arg Val Pro Gly  Arg Arg Pro 
    1310                 1315                 1320             


Pro Ala  Pro Gln Gln Pro Pro  Lys Pro Cys Asp Ser  Gln Pro Cys 
    1325                 1330                 1335             


Phe His  Gly Gly Thr Cys Gln  Asp Trp Ala Leu Gly  Gly Gly Phe 
    1340                 1345                 1350             


Thr Cys  Ser Cys Pro Ala Gly  Arg Gly Gly Ala Val  Cys Glu Lys 
    1355                 1360                 1365             


Val Leu  Gly Ala Pro Val Pro  Ala Phe Glu Gly Arg  Ser Phe Leu 
    1370                 1375                 1380             


Ala Phe  Pro Thr Leu Arg Ala  Tyr His Thr Leu Arg  Leu Ala Leu 
    1385                 1390                 1395             


Glu Phe  Arg Ala Leu Glu Pro  Gln Gly Leu Leu Leu  Tyr Asn Gly 
    1400                 1405                 1410             


Asn Ala  Arg Gly Lys Asp Phe  Leu Ala Leu Ala Leu  Leu Asp Gly 
    1415                 1420                 1425             


Arg Val  Gln Leu Arg Phe Asp  Thr Gly Ser Gly Pro  Ala Val Leu 
    1430                 1435                 1440             


Thr Ser  Ala Val Pro Val Glu  Pro Gly Gln Trp His  Arg Leu Glu 
    1445                 1450                 1455             


Leu Ser  Arg His Trp Arg Arg  Gly Thr Leu Ser Val  Asp Gly Glu 
    1460                 1465                 1470             


Thr Pro  Val Leu Gly Glu Ser  Pro Ser Gly Thr Asp  Gly Leu Asn 
    1475                 1480                 1485             


Leu Asp  Thr Asp Leu Phe Val  Gly Gly Val Pro Glu  Asp Gln Ala 
    1490                 1495                 1500             


Ala Val  Ala Leu Glu Arg Thr  Phe Val Gly Ala Gly  Leu Arg Gly 
    1505                 1510                 1515             


Cys Ile  Arg Leu Leu Asp Val  Asn Asn Gln Arg Leu  Glu Leu Gly 
    1520                 1525                 1530             


Ile Gly  Pro Gly Ala Ala Thr  Arg Gly Ser Gly Val  Gly Glu Cys 
    1535                 1540                 1545             


Gly Asp  His Pro Cys Leu Pro  Asn Pro Cys His Gly  Gly Ala Pro 
    1550                 1555                 1560             


Cys Gln  Asn Leu Glu Ala Gly  Arg Phe His Cys Gln  Cys Pro Pro 
    1565                 1570                 1575             


Gly Arg  Val Gly Pro Thr Cys  Ala Asp Glu Lys Ser  Pro Cys Gln 
    1580                 1585                 1590             


Pro Asn  Pro Cys His Gly Ala  Ala Pro Cys Arg Val  Leu Pro Glu 
    1595                 1600                 1605             


Gly Gly  Ala Gln Cys Glu Cys  Pro Leu Gly Arg Glu  Gly Thr Phe 
    1610                 1615                 1620             


Cys Gln  Thr Ala Ser Gly Gln  Asp Gly Ser Gly Pro  Phe Leu Ala 
    1625                 1630                 1635             


Asp Phe  Asn Gly Phe Ser His  Leu Glu Leu Arg Gly  Leu His Thr 
    1640                 1645                 1650             


Phe Ala  Arg Asp Leu Gly Glu  Lys Met Ala Leu Glu  Val Val Phe 
    1655                 1660                 1665             


Leu Ala  Arg Gly Pro Ser Gly  Leu Leu Leu Tyr Asn  Gly Gln Lys 
    1670                 1675                 1680             


Thr Asp  Gly Lys Gly Asp Phe  Val Ser Leu Ala Leu  Arg Asp Arg 
    1685                 1690                 1695             


Arg Leu  Glu Phe Arg Tyr Asp  Leu Gly Lys Gly Ala  Ala Val Ile 
    1700                 1705                 1710             


Arg Ser  Arg Glu Pro Val Thr  Leu Gly Ala Trp Thr  Arg Val Ser 
    1715                 1720                 1725             


Leu Glu  Arg Asn Gly Arg Lys  Gly Ala Leu Arg Val  Gly Asp Gly 
    1730                 1735                 1740             


Pro Arg  Val Leu Gly Glu Ser  Pro Val Pro His Thr  Val Leu Asn 
    1745                 1750                 1755             


Leu Lys  Glu Pro Leu Tyr Val  Gly Gly Ala Pro Asp  Phe Ser Lys 
    1760                 1765                 1770             


Leu Ala  Arg Ala Ala Ala Val  Ser Ser Gly Phe Asp  Gly Ala Ile 
    1775                 1780                 1785             


Gln Leu  Val Ser Leu Gly Gly  Arg Gln Leu Leu Thr  Pro Glu His 
    1790                 1795                 1800             


Val Leu  Arg Gln Val Asp Val  Thr Ser Phe Ala Gly  His Pro Cys 
    1805                 1810                 1815             


Thr Arg  Ala Ser Gly His Pro  Cys Leu Asn Gly Ala  Ser Cys Val 
    1820                 1825                 1830             


Pro Arg  Glu Ala Ala Tyr Val  Cys Leu Cys Pro Gly  Gly Phe Ser 
    1835                 1840                 1845             


Gly Pro  His Cys Glu Lys Gly  Leu Val Glu Lys Ser  Ala Gly Asp 
    1850                 1855                 1860             


Val Asp  Thr Leu Ala Phe Asp  Gly Arg Thr Phe Val  Glu Tyr Leu 
    1865                 1870                 1875             


Asn Ala  Val Thr Glu Ser Glu  Lys Ala Leu Gln Ser  Asn His Phe 
    1880                 1885                 1890             


Glu Leu  Ser Leu Arg Thr Glu  Ala Thr Gln Gly Leu  Val Leu Trp 
    1895                 1900                 1905             


Ser Gly  Lys Ala Thr Glu Arg  Ala Asp Tyr Val Ala  Leu Ala Ile 
    1910                 1915                 1920             


Val Asp  Gly His Leu Gln Leu  Ser Tyr Asn Leu Gly  Ser Gln Pro 
    1925                 1930                 1935             


Val Val  Leu Arg Ser Thr Val  Pro Val Asn Thr Asn  Arg Trp Leu 
    1940                 1945                 1950             


Arg Val  Val Ala His Arg Glu  Gln Arg Glu Gly Ser  Leu Gln Val 
    1955                 1960                 1965             


Gly Asn  Glu Ala Pro Val Thr  Gly Ser Ser Pro Leu  Gly Ala Thr 
    1970                 1975                 1980             


Gln Leu  Asp Thr Asp Gly Ala  Leu Trp Leu Gly Gly  Leu Pro Glu 
    1985                 1990                 1995             


Leu Pro  Val Gly Pro Ala Leu  Pro Lys Ala Tyr Gly  Thr Gly Phe 
    2000                 2005                 2010             


Val Gly  Cys Leu Arg Asp Val  Val Val Gly Arg His  Pro Leu His 
    2015                 2020                 2025             


Leu Leu  Glu Asp Ala Val Thr  Lys Pro Glu Leu Arg  Pro Cys Pro 
    2030                 2035                 2040             


Thr Pro  
    2045 


<210>  6
<211>  1940
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Pro Pro Leu Pro Leu Glu His Arg Pro Arg Gln Glu Pro Gly Ala 
1               5                   10                  15      


Ser Met Leu Val Arg Tyr Phe Met Ile Pro Cys Asn Ile Cys Leu Ile 
            20                  25                  30          


Leu Leu Ala Thr Ser Thr Leu Gly Phe Ala Val Leu Leu Phe Leu Ser 
        35                  40                  45              


Asn Tyr Lys Pro Gly Ile His Phe Thr Pro Ala Pro Pro Thr Pro Pro 
    50                  55                  60                  


Asp Val Cys Arg Gly Met Leu Cys Gly Phe Gly Ala Val Cys Glu Pro 
65                  70                  75                  80  


Ser Val Glu Asp Pro Gly Arg Ala Ser Cys Val Cys Lys Lys Asn Ala 
                85                  90                  95      


Cys Pro Ala Thr Val Ala Pro Val Cys Gly Ser Asp Ala Ser Thr Tyr 
            100                 105                 110         


Ser Asn Glu Cys Glu Leu Gln Arg Ala Gln Cys Asn Gln Gln Arg Arg 
        115                 120                 125             


Ile Arg Leu Leu Arg Gln Gly Pro Cys Gly Ser Arg Asp Pro Cys Ala 
    130                 135                 140                 


Asn Val Thr Cys Ser Phe Gly Ser Thr Cys Val Pro Ser Ala Asp Gly 
145                 150                 155                 160 


Gln Thr Ala Ser Cys Leu Cys Pro Thr Thr Cys Phe Gly Ala Pro Asp 
                165                 170                 175     


Gly Thr Val Cys Gly Ser Asp Gly Val Asp Tyr Pro Ser Glu Cys Gln 
            180                 185                 190         


Leu Leu Ser His Ala Cys Ala Ser Gln Glu His Ile Phe Lys Lys Phe 
        195                 200                 205             


Asn Gly Pro Cys Asp Pro Cys Gln Gly Ser Met Ser Asp Leu Asn His 
    210                 215                 220                 


Ile Cys Arg Val Asn Pro Arg Thr Arg His Pro Glu Met Leu Leu Arg 
225                 230                 235                 240 


Pro Glu Asn Cys Pro Ala Gln His Thr Pro Ile Cys Gly Asp Asp Gly 
                245                 250                 255     


Val Thr Tyr Glu Asn Asp Cys Val Met Ser Arg Ile Gly Ala Thr Arg 
            260                 265                 270         


Gly Leu Leu Leu Gln Lys Val Arg Ser Gly Gln Cys Gln Thr Arg Asp 
        275                 280                 285             


Gln Cys Pro Glu Thr Cys Gln Phe Asn Ser Val Cys Leu Ser Arg Arg 
    290                 295                 300                 


Gly Arg Pro His Cys Ser Cys Asp Arg Val Thr Cys Asp Gly Ser Tyr 
305                 310                 315                 320 


Arg Pro Val Cys Ala Gln Asp Gly His Thr Tyr Asn Asn Asp Cys Trp 
                325                 330                 335     


Arg Gln Gln Ala Glu Cys Arg Gln Gln Arg Ala Ile Pro Pro Lys His 
            340                 345                 350         


Gln Gly Pro Cys Asp Gln Thr Pro Ser Pro Cys His Gly Val Gln Cys 
        355                 360                 365             


Ala Phe Gly Ala Val Cys Thr Val Lys Asn Gly Lys Ala Glu Cys Glu 
    370                 375                 380                 


Cys Gln Arg Val Cys Ser Gly Ile Tyr Asp Pro Val Cys Gly Ser Asp 
385                 390                 395                 400 


Gly Val Thr Tyr Gly Ser Val Cys Glu Leu Glu Ser Met Ala Cys Thr 
                405                 410                 415     


Leu Gly Arg Glu Ile Gln Val Ala Arg Arg Gly Pro Cys Asp Pro Cys 
            420                 425                 430         


Gly Gln Cys Arg Phe Gly Ser Leu Cys Glu Val Glu Thr Gly Arg Cys 
        435                 440                 445             


Val Cys Pro Ser Glu Cys Val Glu Ser Ala Gln Pro Val Cys Gly Ser 
    450                 455                 460                 


Asp Gly His Thr Tyr Ala Ser Glu Cys Glu Leu His Val His Ala Cys 
465                 470                 475                 480 


Thr His Gln Ile Ser Leu Tyr Val Ala Ser Ala Gly His Cys Gln Thr 
                485                 490                 495     


Cys Gly Glu Lys Val Cys Thr Phe Gly Ala Val Cys Ser Ala Gly Gln 
            500                 505                 510         


Cys Val Cys Pro Arg Cys Glu His Pro Pro Pro Gly Pro Val Cys Gly 
        515                 520                 525             


Ser Asp Gly Val Thr Tyr Leu Ser Ala Cys Glu Leu Arg Glu Ala Ala 
    530                 535                 540                 


Cys Gln Gln Gln Val Gln Ile Glu Glu Ala His Ala Gly Pro Cys Glu 
545                 550                 555                 560 


Pro Ala Glu Cys Gly Ser Gly Gly Ser Gly Ser Gly Glu Asp Asp Glu 
                565                 570                 575     


Cys Glu Gln Glu Leu Cys Arg Gln Arg Gly Gly Ile Trp Asp Glu Asp 
            580                 585                 590         


Ser Glu Asp Gly Pro Cys Val Cys Asp Phe Ser Cys Gln Ser Val Pro 
        595                 600                 605             


Arg Ser Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Thr Glu Cys 
    610                 615                 620                 


Asp Leu Lys Lys Ala Arg Cys Glu Ser Gln Gln Glu Leu Tyr Val Ala 
625                 630                 635                 640 


Ala Gln Gly Ala Cys Arg Gly Pro Thr Leu Ala Pro Leu Leu Pro Val 
                645                 650                 655     


Ala Phe Pro His Cys Ala Gln Thr Pro Tyr Gly Cys Cys Gln Asp Asn 
            660                 665                 670         


Phe Thr Ala Ala Gln Gly Val Gly Leu Ala Gly Cys Pro Ser Thr Cys 
        675                 680                 685             


His Cys Asn Pro His Gly Ser Tyr Ser Gly Thr Cys Asp Pro Ala Thr 
    690                 695                 700                 


Gly Gln Cys Ser Cys Arg Pro Gly Val Gly Gly Leu Arg Cys Asp Arg 
705                 710                 715                 720 


Cys Glu Pro Gly Phe Trp Asn Phe Arg Gly Ile Val Thr Asp Gly His 
                725                 730                 735     


Ser Gly Cys Thr Pro Cys Ser Cys Asp Pro Arg Gly Ala Val Arg Asp 
            740                 745                 750         


Asp Cys Glu Gln Met Thr Gly Leu Cys Ser Cys Arg Pro Gly Val Ala 
        755                 760                 765             


Gly Pro Lys Cys Gly Gln Cys Pro Asp Gly Gln Val Leu Gly His Leu 
    770                 775                 780                 


Gly Cys Glu Ala Asp Pro Met Thr Pro Val Thr Cys Val Glu Ile His 
785                 790                 795                 800 


Cys Glu Phe Gly Ala Ser Cys Val Glu Lys Ala Gly Phe Ala Gln Cys 
                805                 810                 815     


Ile Cys Pro Thr Leu Thr Cys Pro Glu Ala Asn Ser Thr Lys Val Cys 
            820                 825                 830         


Gly Ser Asp Gly Val Thr Tyr Gly Asn Glu Cys Gln Leu Lys Ala Ile 
        835                 840                 845             


Ala Cys Arg Gln Arg Leu Asp Ile Ser Thr Gln Ser Leu Gly Pro Cys 
    850                 855                 860                 


Gln Glu Ser Val Thr Pro Gly Ala Ser Pro Thr Ser Ala Ser Met Thr 
865                 870                 875                 880 


Thr Pro Arg His Ile Leu Ser Lys Thr Leu Pro Phe Pro His Asn Ser 
                885                 890                 895     


Leu Pro Leu Ser Pro Gly Ser Thr Thr His Asp Trp Pro Thr Pro Leu 
            900                 905                 910         


Pro Ile Ser Pro His Thr Thr Val Ser Ile Pro Arg Ser Thr Ala Trp 
        915                 920                 925             


Pro Val Leu Thr Val Pro Pro Thr Ala Ala Ala Ser Asp Val Thr Ser 
    930                 935                 940                 


Leu Ala Thr Ser Ile Phe Ser Glu Ser Gly Ser Ala Asn Gly Ser Gly 
945                 950                 955                 960 


Asp Glu Glu Leu Ser Gly Asp Glu Glu Ala Ser Gly Gly Gly Ser Gly 
                965                 970                 975     


Gly Leu Glu Pro Pro Val Gly Ser Ile Val Val Thr His Gly Pro Pro 
            980                 985                 990         


Ile Glu Arg Ala Ser Cys Tyr Asn  Ser Pro Leu Gly Cys  Cys Ser Asp 
        995                 1000                 1005             


Gly Lys  Thr Pro Ser Leu Asp  Ser Glu Gly Ser Asn  Cys Pro Ala 
    1010                 1015                 1020             


Thr Lys  Ala Phe Gln Gly Val  Leu Glu Leu Glu Gly  Val Glu Gly 
    1025                 1030                 1035             


Gln Glu  Leu Phe Tyr Thr Pro  Glu Met Ala Asp Pro  Lys Ser Glu 
    1040                 1045                 1050             


Leu Phe  Gly Glu Thr Ala Arg  Ser Ile Glu Ser Thr  Leu Asp Asp 
    1055                 1060                 1065             


Leu Phe  Arg Asn Ser Asp Val  Lys Lys Asp Phe Trp  Ser Val Arg 
    1070                 1075                 1080             


Leu Arg  Glu Leu Gly Pro Gly  Lys Leu Val Arg Ala  Ile Val Asp 
    1085                 1090                 1095             


Val His  Phe Asp Pro Thr Thr  Ala Phe Gln Ala Ser  Asp Val Gly 
    1100                 1105                 1110             


Gln Ala  Leu Leu Arg Gln Ile  Gln Val Ser Arg Pro  Trp Ala Leu 
    1115                 1120                 1125             


Ala Val  Arg Arg Pro Leu Gln  Glu His Val Arg Phe  Leu Asp Phe 
    1130                 1135                 1140             


Asp Trp  Phe Pro Thr Phe Phe  Thr Gly Ala Ala Thr  Gly Thr Thr 
    1145                 1150                 1155             


Ala Ala  Met Ala Thr Ala Arg  Ala Thr Thr Val Ser  Arg Leu Pro 
    1160                 1165                 1170             


Ala Ser  Ser Val Thr Pro Arg  Val Tyr Pro Ser His  Thr Ser Arg 
    1175                 1180                 1185             


Pro Val  Gly Arg Thr Thr Ala  Pro Pro Thr Thr Arg  Arg Pro Pro 
    1190                 1195                 1200             


Thr Thr  Ala Thr Asn Met Asp  Arg Pro Arg Thr Pro  Gly His Gln 
    1205                 1210                 1215             


Gln Pro  Ser Lys Ser Cys Asp  Ser Gln Pro Cys Leu  His Gly Gly 
    1220                 1225                 1230             


Thr Cys  Gln Asp Gln Asp Ser  Gly Lys Gly Phe Thr  Cys Ser Cys 
    1235                 1240                 1245             


Thr Ala  Gly Arg Gly Gly Ser  Val Cys Glu Lys Val  Gln Pro Pro 
    1250                 1255                 1260             


Ser Met  Pro Ala Phe Lys Gly  His Ser Phe Leu Ala  Phe Pro Thr 
    1265                 1270                 1275             


Leu Arg  Ala Tyr His Thr Leu  Arg Leu Ala Leu Glu  Phe Arg Ala 
    1280                 1285                 1290             


Leu Glu  Thr Glu Gly Leu Leu  Leu Tyr Asn Gly Asn  Ala Arg Gly 
    1295                 1300                 1305             


Lys Asp  Phe Leu Ala Leu Ala  Leu Leu Asp Gly Arg  Val Gln Phe 
    1310                 1315                 1320             


Arg Phe  Asp Thr Gly Ser Gly  Pro Ala Val Leu Thr  Ser Leu Val 
    1325                 1330                 1335             


Pro Val  Glu Pro Gly Arg Trp  His Arg Leu Glu Leu  Ser Arg His 
    1340                 1345                 1350             


Trp Arg  Gln Gly Thr Leu Ser  Val Asp Gly Glu Thr  Pro Val Val 
    1355                 1360                 1365             


Gly Glu  Ser Pro Ser Gly Thr  Asp Gly Leu Asn Leu  Asp Thr Asn 
    1370                 1375                 1380             


Leu Tyr  Val Gly Gly Ile Pro  Glu Glu Gln Val Ala  Met Val Leu 
    1385                 1390                 1395             


Asp Arg  Thr Ser Val Gly Val  Gly Leu Lys Gly Cys  Ile Arg Met 
    1400                 1405                 1410             


Leu Asp  Ile Asn Asn Gln Gln  Leu Glu Leu Ser Asp  Trp Gln Arg 
    1415                 1420                 1425             


Ala Ala  Val Gln Ser Ser Gly  Val Gly Glu Cys Gly  Asp His Pro 
    1430                 1435                 1440             


Cys Leu  Pro Asn Pro Cys His  Gly Gly Ala Leu Cys  Gln Ala Leu 
    1445                 1450                 1455             


Glu Ala  Gly Met Phe Leu Cys  Gln Cys Pro Pro Gly  Arg Phe Gly 
    1460                 1465                 1470             


Pro Thr  Cys Ala Asp Glu Lys  Ser Pro Cys Gln Pro  Asn Pro Cys 
    1475                 1480                 1485             


His Gly  Ala Ala Pro Cys Arg  Val Leu Ser Ser Gly  Gly Ala Lys 
    1490                 1495                 1500             


Cys Glu  Cys Pro Leu Gly Arg  Ser Gly Thr Phe Cys  Gln Thr Val 
    1505                 1510                 1515             


Leu Glu  Thr Ala Gly Ser Arg  Pro Phe Leu Ala Asp  Phe Asn Gly 
    1520                 1525                 1530             


Phe Ser  Tyr Leu Glu Leu Lys  Gly Leu His Thr Phe  Glu Arg Asp 
    1535                 1540                 1545             


Leu Gly  Glu Lys Met Ala Leu  Glu Met Val Phe Leu  Ala Arg Gly 
    1550                 1555                 1560             


Pro Ser  Gly Leu Leu Leu Tyr  Asn Gly Gln Lys Thr  Asp Gly Lys 
    1565                 1570                 1575             


Gly Asp  Phe Val Ser Leu Ala  Leu His Asn Arg His  Leu Glu Phe 
    1580                 1585                 1590             


Cys Tyr  Asp Leu Gly Lys Gly  Ala Ala Val Ile Arg  Ser Lys Glu 
    1595                 1600                 1605             


Pro Ile  Ala Leu Gly Thr Trp  Val Arg Val Phe Leu  Glu Arg Asn 
    1610                 1615                 1620             


Gly Arg  Lys Gly Ala Leu Gln  Val Gly Asp Gly Pro  Arg Val Leu 
    1625                 1630                 1635             


Gly Glu  Ser Pro Lys Ser Arg  Lys Val Pro His Thr  Met Leu Asn 
    1640                 1645                 1650             


Leu Lys  Glu Pro Leu Tyr Ile  Gly Gly Ala Pro Asp  Phe Ser Lys 
    1655                 1660                 1665             


Leu Ala  Arg Gly Ala Ala Val  Ser Ser Gly Phe Ser  Gly Val Ile 
    1670                 1675                 1680             


Gln Leu  Val Ser Leu Arg Gly  His Gln Leu Leu Thr  Gln Glu His 
    1685                 1690                 1695             


Val Leu  Arg Ala Val Asp Val  Ser Pro Phe Ala Asp  His Pro Cys 
    1700                 1705                 1710             


Thr Gln  Ala Leu Gly Asn Pro  Cys Leu Asn Gly Gly  Ser Cys Val 
    1715                 1720                 1725             


Pro Arg  Glu Ala Thr Tyr Glu  Cys Leu Cys Pro Gly  Gly Phe Ser 
    1730                 1735                 1740             


Gly Leu  His Cys Glu Lys Gly  Leu Val Glu Lys Ser  Val Gly Asp 
    1745                 1750                 1755             


Leu Glu  Thr Leu Ala Phe Asp  Gly Arg Thr Tyr Ile  Glu Tyr Leu 
    1760                 1765                 1770             


Asn Ala  Val Ile Glu Ser Glu  Lys Ala Leu Gln Ser  Asn His Phe 
    1775                 1780                 1785             


Glu Leu  Ser Leu Arg Thr Glu  Ala Thr Gln Gly Leu  Val Leu Trp 
    1790                 1795                 1800             


Ile Gly  Lys Ala Ala Glu Arg  Ala Asp Tyr Met Ala  Leu Ala Ile 
    1805                 1810                 1815             


Val Asp  Gly His Leu Gln Leu  Ser Tyr Asp Leu Gly  Ser Gln Pro 
    1820                 1825                 1830             


Val Val  Leu Arg Ser Thr Val  Lys Val Asn Thr Asn  Arg Trp Leu 
    1835                 1840                 1845             


Arg Ile  Arg Ala His Arg Glu  His Arg Glu Gly Ser  Leu Gln Val 
    1850                 1855                 1860             


Gly Asn  Glu Ala Pro Val Thr  Gly Ser Ser Pro Leu  Gly Ala Thr 
    1865                 1870                 1875             


Gln Leu  Asp Thr Asp Gly Ala  Leu Trp Leu Gly Gly  Leu Gln Lys 
    1880                 1885                 1890             


Leu Pro  Val Gly Gln Ala Leu  Pro Lys Ala Tyr Gly  Thr Gly Phe 
    1895                 1900                 1905             


Val Gly  Cys Leu Arg Asp Val  Val Val Gly His Arg  Gln Leu His 
    1910                 1915                 1920             


Leu Leu  Glu Asp Ala Val Thr  Lys Pro Glu Leu Arg  Pro Cys Pro 
    1925                 1930                 1935             


Thr Pro  
    1940 


<210>  7
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence encoding Minimal human  Agrin human sequence 
       - G1 + G2

<400>  7

Gly Ala Pro Val Pro Ala Phe Glu Gly Arg Ser Phe Leu Ala Phe Pro 
1               5                   10                  15      


Thr Leu Arg Ala Tyr His Thr Leu Arg Leu Ala Leu Glu Phe Arg Ala 
            20                  25                  30          


Leu Glu Pro Gln Gly Leu Leu Leu Tyr Asn Gly Asn Ala Arg Gly Lys 
        35                  40                  45              


Asp Phe Leu Ala Leu Ala Leu Leu Asp Gly Arg Val Gln Leu Arg Phe 
    50                  55                  60                  


Asp Thr Gly Ser Gly Pro Ala Val Leu Thr Ser Ala Val Pro Val Glu 
65                  70                  75                  80  


Pro Gly Gln Trp His Arg Leu Glu Leu Ser Arg His Trp Arg Arg Gly 
                85                  90                  95      


Thr Leu Ser Val Asp Gly Glu Thr Pro Val Leu Gly Glu Ser Pro Ser 
            100                 105                 110         


Gly Thr Asp Gly Leu Asn Leu Asp Thr Asp Leu Phe Val Gly Gly Val 
        115                 120                 125             


Pro Glu Asp Gln Ala Ala Val Ala Leu Glu Arg Thr Phe Val Gly Ala 
    130                 135                 140                 


Gly Leu Arg Gly Cys Ile Arg Leu Leu Asp Val Asn Asn Gln Arg Leu 
145                 150                 155                 160 


Glu Leu Gly Ile Gly Pro Gly Ala Ala Thr Arg Gly Ser Gly Val Gly 
                165                 170                 175     


Glu Cys Gly Asp His Pro Cys Leu Pro Asn Pro Cys His Gly Gly Ala 
            180                 185                 190         


Pro Cys Gln Asn Leu Glu Ala Gly Arg Phe His Cys Gln Cys Pro Pro 
        195                 200                 205             


Gly Arg Val Gly Pro Thr Cys Ala Asp Glu Lys Ser Pro Cys Gln Pro 
    210                 215                 220                 


Asn Pro Cys His Gly Ala Ala Pro Cys Arg Val Leu Pro Glu Gly Gly 
225                 230                 235                 240 


Ala Gln Cys Glu Cys Pro Leu Gly Arg Glu Gly Thr Phe Cys Gln Thr 
                245                 250                 255     


Ala Ser Gly Gln Asp Gly Ser Gly Pro Phe Leu Ala Asp Phe Asn Gly 
            260                 265                 270         


Phe Ser His Leu Glu Leu Arg Gly Leu His Thr Phe Ala Arg Asp Leu 
        275                 280                 285             


Gly Glu Lys Met Ala Leu Glu Val Val Phe Leu Ala Arg Gly Pro Ser 
    290                 295                 300                 


Gly Leu Leu Leu Tyr Asn Gly Gln Lys Thr Asp Gly Lys Gly Asp Phe 
305                 310                 315                 320 


Val Ser Leu Ala Leu Arg Asp Arg Arg Leu Glu Phe Arg Tyr Asp Leu 
                325                 330                 335     


Gly Lys Gly Ala Ala Val Ile Arg Ser Arg Glu Pro Val Thr Leu Gly 
            340                 345                 350         


Ala Trp Thr Arg Val Ser Leu Glu Arg Asn Gly Arg Lys Gly Ala Leu 
        355                 360                 365             


Arg Val Gly Asp Gly Pro Arg Val Leu Gly Glu Ser Pro Lys Ser Arg 
    370                 375                 380                 


Lys Val Pro His Thr Val Leu Asn Leu Lys Glu Pro Leu Tyr Val Gly 
385                 390                 395                 400 


Gly Ala Pro Asp Phe Ser Lys Leu Ala Arg Ala Ala Ala Val Ser Ser 
                405                 410                 415     


Gly Phe Asp Gly Ala Ile Gln Leu Val Ser Leu Gly Gly Arg Gln Leu 
            420                 425                 430         


Leu Thr Pro Glu His Val Leu Arg Gln Val Asp Val Thr Ser Phe Ala 
        435                 440                 445             


Gly His Pro Cys 
    450         


<210>  8
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence encoding Minimal human  Agrin human sequence 
       -  G2 only

<400>  8

Pro Phe Leu Ala Asp Phe Asn Gly Phe Ser His Leu Glu Leu Arg Gly 
1               5                   10                  15      


Leu His Thr Phe Ala Arg Asp Leu Gly Glu Lys Met Ala Leu Glu Val 
            20                  25                  30          


Val Phe Leu Ala Arg Gly Pro Ser Gly Leu Leu Leu Tyr Asn Gly Gln 
        35                  40                  45              


Lys Thr Asp Gly Lys Gly Asp Phe Val Ser Leu Ala Leu Arg Asp Arg 
    50                  55                  60                  


Arg Leu Glu Phe Arg Tyr Asp Leu Gly Lys Gly Ala Ala Val Ile Arg 
65                  70                  75                  80  


Ser Arg Glu Pro Val Thr Leu Gly Ala Trp Thr Arg Val Ser Leu Glu 
                85                  90                  95      


Arg Asn Gly Arg Lys Gly Ala Leu Arg Val Gly Asp Gly Pro Arg Val 
            100                 105                 110         


Leu Gly Glu Ser Pro Lys Ser Arg Lys Val Pro His Thr Val Leu Asn 
        115                 120                 125             


Leu Lys Glu Pro Leu Tyr Val Gly Gly Ala Pro Asp Phe Ser Lys Leu 
    130                 135                 140                 


Ala Arg Ala Ala Ala Val Ser Ser Gly Phe Asp Gly Ala Ile Gln Leu 
145                 150                 155                 160 


Val Ser Leu Gly Gly Arg Gln Leu Leu Thr Pro Glu His Val Leu Arg 
                165                 170                 175     


Gln Val Asp Val Thr Ser Phe Ala Gly His Pro Cys 
            180                 185             


<210>  9
<211>  2034
<212>  PRT
<213>  Mus musculus

<400>  9

Met Val Arg Pro Arg Leu Ser Phe Pro Ala Pro Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Leu Leu Ala Ala Ala Ala Pro Ala Val Pro Gly Ala Ser Gly Thr 
            20                  25                  30          


Cys Pro Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val 
        35                  40                  45              


Leu Thr Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His 
    50                  55                  60                  


Thr Tyr Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp 
65                  70                  75                  80  


Val Val Ala Gln Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile 
                85                  90                  95      


Gly Gly Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly 
            100                 105                 110         


Asp Thr Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro 
        115                 120                 125             


Ala His Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr 
    130                 135                 140                 


Leu Arg Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly 
145                 150                 155                 160 


Ile His Phe Thr Ala Ala Pro Ser Met Pro Pro Asp Val Cys Arg Gly 
                165                 170                 175     


Met Leu Cys Gly Phe Gly Ala Val Cys Glu Pro Ser Val Glu Asp Pro 
            180                 185                 190         


Gly Arg Ala Ser Cys Val Cys Lys Lys Asn Val Cys Pro Ala Met Val 
        195                 200                 205             


Ala Pro Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu 
    210                 215                 220                 


Leu Gln Arg Ala Gln Cys Asn Gln Gln Arg Arg Ile Arg Leu Leu Arg 
225                 230                 235                 240 


Gln Gly Pro Cys Gly Ser Arg Asp Pro Cys Ala Asn Val Thr Cys Ser 
                245                 250                 255     


Phe Gly Ser Thr Cys Val Pro Ser Ala Asp Gly Gln Thr Ala Ser Cys 
            260                 265                 270         


Leu Cys Pro Thr Thr Cys Phe Gly Ala Pro Asp Gly Thr Val Cys Gly 
        275                 280                 285             


Ser Asp Gly Val Asp Tyr Pro Ser Glu Cys Gln Leu Leu Arg His Ala 
    290                 295                 300                 


Cys Ala Asn Gln Glu His Ile Phe Lys Lys Phe Asp Gly Pro Cys Asp 
305                 310                 315                 320 


Pro Cys Gln Gly Ser Met Ser Asp Leu Asn His Ile Cys Arg Val Asn 
                325                 330                 335     


Pro Arg Thr Arg His Pro Glu Met Leu Leu Arg Pro Glu Asn Cys Pro 
            340                 345                 350         


Ala Gln His Thr Pro Ile Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn 
        355                 360                 365             


Asp Cys Val Met Ser Arg Ile Gly Ala Ala Arg Gly Leu Leu Leu Gln 
    370                 375                 380                 


Lys Val Arg Ser Gly Gln Cys Gln Thr Arg Asp Gln Cys Pro Glu Thr 
385                 390                 395                 400 


Cys Gln Phe Asn Ser Val Cys Leu Ser Arg Arg Gly Arg Pro His Cys 
                405                 410                 415     


Ser Cys Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala 
            420                 425                 430         


Gln Asp Gly His Thr Tyr Asp Asn Asp Cys Trp Arg Gln Gln Ala Glu 
        435                 440                 445             


Cys Arg Gln Gln Gln Thr Ile Pro Pro Lys His Gln Gly Pro Cys Asp 
    450                 455                 460                 


Gln Thr Pro Ser Pro Cys Arg Gly Ala Gln Cys Ala Phe Gly Ala Thr 
465                 470                 475                 480 


Cys Thr Val Lys Asn Gly Lys Ala Val Cys Glu Cys Gln Arg Val Cys 
                485                 490                 495     


Ser Gly Gly Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly 
            500                 505                 510         


Ser Val Cys Glu Leu Glu Ser Met Ala Cys Thr Leu Gly Arg Glu Ile 
        515                 520                 525             


Arg Val Ala Arg Arg Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe 
    530                 535                 540                 


Gly Ser Leu Cys Glu Val Glu Thr Gly Arg Cys Val Cys Pro Ser Glu 
545                 550                 555                 560 


Cys Val Glu Ser Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr 
                565                 570                 575     


Ala Ser Glu Cys Glu Leu His Val His Ala Cys Thr His Gln Ile Ser 
            580                 585                 590         


Leu Tyr Val Ala Ser Ala Gly His Cys Gln Thr Cys Gly Glu Thr Val 
        595                 600                 605             


Cys Thr Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg 
    610                 615                 620                 


Cys Glu His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr 
625                 630                 635                 640 


Tyr Leu Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Gln Gln Gln Val 
                645                 650                 655     


Gln Ile Glu Glu Ala Arg Ala Gly Pro Cys Glu Pro Ala Glu Cys Gly 
            660                 665                 670         


Ser Gly Gly Ser Gly Ser Gly Glu Asp Asn Ala Cys Glu Gln Glu Leu 
        675                 680                 685             


Cys Arg Gln His Gly Gly Val Trp Asp Glu Asp Ser Glu Asp Gly Pro 
    690                 695                 700                 


Cys Val Cys Asp Phe Ser Cys Gln Ser Val Leu Lys Ser Pro Val Cys 
705                 710                 715                 720 


Gly Ser Asp Gly Val Thr Tyr Ser Thr Glu Cys His Leu Lys Lys Ala 
                725                 730                 735     


Arg Cys Glu Ala Arg Gln Glu Leu Tyr Val Ala Ala Gln Gly Ala Cys 
            740                 745                 750         


Arg Gly Pro Thr Leu Ala Pro Leu Leu Pro Met Ala Ser Pro His Cys 
        755                 760                 765             


Ala Gln Thr Pro Tyr Gly Cys Cys Gln Asp Asn Val Thr Ala Ala Gln 
    770                 775                 780                 


Gly Val Gly Leu Ala Gly Cys Pro Ser Thr Cys His Cys Asn Pro His 
785                 790                 795                 800 


Gly Ser Tyr Ser Gly Thr Cys Asp Pro Val Thr Gly Gln Cys Ser Cys 
                805                 810                 815     


Arg Pro Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe 
            820                 825                 830         


Trp Asn Phe Arg Gly Ile Val Thr Asp Gly His Ser Gly Cys Thr Pro 
        835                 840                 845             


Cys Ser Cys Asp Pro Arg Gly Ala Val Arg Asp Asp Cys Glu Gln Met 
    850                 855                 860                 


Thr Gly Leu Cys Ser Cys Arg Pro Gly Val Ala Gly Pro Lys Cys Gly 
865                 870                 875                 880 


Gln Cys Pro Asp Gly Gln Ala Leu Gly His Leu Gly Cys Glu Ala Asp 
                885                 890                 895     


Pro Thr Thr Pro Val Thr Cys Val Glu Met His Cys Glu Phe Gly Ala 
            900                 905                 910         


Ser Cys Val Glu Glu Ala Gly Phe Ala Gln Cys Val Cys Pro Thr Leu 
        915                 920                 925             


Thr Cys Pro Glu Ala Asn Ser Thr Lys Val Cys Gly Ser Asp Gly Val 
    930                 935                 940                 


Thr Tyr Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Arg 
945                 950                 955                 960 


Leu Asp Ile Ser Ile Gln Ser Leu Gly Pro Cys Arg Glu Ser Val Ala 
                965                 970                 975     


Pro Gly Val Ser Pro Thr Ser Ala Ser Met Thr Thr Pro Arg His Ile 
            980                 985                 990         


Leu Ser Arg Thr Leu Ala Ser Pro  His Ser Ser Leu Pro  Leu Ser Pro 
        995                 1000                 1005             


Ser Thr  Thr Ala His Asp Trp  Pro Thr Pro Leu Pro  Thr Ser Pro 
    1010                 1015                 1020             


Gln Thr  Val Val Gly Thr Pro  Arg Ser Thr Ala Ala  Thr Pro Ser 
    1025                 1030                 1035             


Asp Val  Ala Ser Leu Ala Thr  Ala Ile Phe Arg Glu  Ser Gly Ser 
    1040                 1045                 1050             


Thr Asn  Gly Ser Gly Asp Glu  Glu Leu Ser Gly Asp  Glu Glu Ala 
    1055                 1060                 1065             


Ser Gly  Gly Gly Ser Gly Gly  Leu Glu Pro Pro Val  Gly Ser Val 
    1070                 1075                 1080             


Val Val  Thr His Gly Pro Pro  Ile Glu Arg Ala Ser  Cys Tyr Asn 
    1085                 1090                 1095             


Ser Pro  Leu Gly Cys Cys Ser  Asp Gly Lys Thr Pro  Ser Leu Asp 
    1100                 1105                 1110             


Ser Glu  Gly Ser Asn Cys Pro  Ala Thr Lys Ala Phe  Gln Gly Val 
    1115                 1120                 1125             


Leu Glu  Leu Glu Gly Val Glu  Gly Gln Glu Leu Phe  Tyr Thr Pro 
    1130                 1135                 1140             


Glu Met  Ala Asp Pro Lys Ser  Glu Leu Phe Gly Glu  Thr Ala Arg 
    1145                 1150                 1155             


Ser Ile  Glu Ser Thr Leu Asp  Asp Leu Phe Arg Asn  Ser Asp Val 
    1160                 1165                 1170             


Lys Lys  Asp Phe Trp Ser Ile  Arg Leu Arg Glu Leu  Gly Pro Gly 
    1175                 1180                 1185             


Lys Leu  Val Arg Ala Ile Val  Asp Val His Phe Asp  Pro Thr Thr 
    1190                 1195                 1200             


Ala Phe  Gln Ala Pro Asp Val  Gly Gln Ala Leu Leu  Gln Gln Ile 
    1205                 1210                 1215             


Gln Val  Ser Arg Pro Trp Ala  Leu Ala Val Arg Arg  Pro Leu Arg 
    1220                 1225                 1230             


Glu His  Val Arg Phe Leu Asp  Phe Asp Trp Phe Pro  Thr Phe Phe 
    1235                 1240                 1245             


Thr Gly  Ala Ala Thr Gly Thr  Thr Ala Ala Val Ala  Thr Ala Arg 
    1250                 1255                 1260             


Ala Thr  Thr Val Ser Arg Leu  Ser Ala Ser Ser Val  Thr Pro Arg 
    1265                 1270                 1275             


Val Tyr  Pro Ser Tyr Thr Ser  Arg Pro Val Gly Arg  Thr Thr Ala 
    1280                 1285                 1290             


Pro Leu  Thr Thr Arg Arg Pro  Pro Thr Thr Thr Ala  Ser Ile Asp 
    1295                 1300                 1305             


Arg Pro  Arg Thr Pro Gly Pro  Gln Arg Pro Pro Lys  Ser Cys Asp 
    1310                 1315                 1320             


Ser Gln  Pro Cys Leu His Gly  Gly Thr Cys Gln Asp  Leu Asp Ser 
    1325                 1330                 1335             


Gly Lys  Gly Phe Ser Cys Ser  Cys Thr Ala Gly Arg  Ala Gly Thr 
    1340                 1345                 1350             


Val Cys  Glu Lys Val Gln Leu  Pro Ser Val Pro Ala  Phe Lys Gly 
    1355                 1360                 1365             


His Ser  Phe Leu Ala Phe Pro  Thr Leu Arg Ala Tyr  His Thr Leu 
    1370                 1375                 1380             


Arg Leu  Ala Leu Glu Phe Arg  Ala Leu Glu Thr Glu  Gly Leu Leu 
    1385                 1390                 1395             


Leu Tyr  Asn Gly Asn Ala Arg  Gly Lys Asp Phe Leu  Ala Leu Ala 
    1400                 1405                 1410             


Leu Leu  Asp Gly His Val Gln  Phe Arg Phe Asp Thr  Gly Ser Gly 
    1415                 1420                 1425             


Pro Ala  Val Leu Thr Ser Leu  Val Pro Val Glu Pro  Gly Arg Trp 
    1430                 1435                 1440             


His Arg  Leu Glu Leu Ser Arg  His Trp Arg Gln Gly  Thr Leu Ser 
    1445                 1450                 1455             


Val Asp  Gly Glu Ala Pro Val  Val Gly Glu Ser Pro  Ser Gly Thr 
    1460                 1465                 1470             


Asp Gly  Leu Asn Leu Asp Thr  Lys Leu Tyr Val Gly  Gly Leu Pro 
    1475                 1480                 1485             


Glu Glu  Gln Val Ala Thr Val  Leu Asp Arg Thr Ser  Val Gly Ile 
    1490                 1495                 1500             


Gly Leu  Lys Gly Cys Ile Arg  Met Leu Asp Ile Asn  Asn Gln Gln 
    1505                 1510                 1515             


Leu Glu  Leu Ser Asp Trp Gln  Arg Ala Val Val Gln  Ser Ser Gly 
    1520                 1525                 1530             


Val Gly  Glu Cys Gly Asp His  Pro Cys Ser Pro Asn  Pro Cys His 
    1535                 1540                 1545             


Gly Gly  Ala Leu Cys Gln Ala  Leu Glu Ala Gly Val  Phe Leu Cys 
    1550                 1555                 1560             


Gln Cys  Pro Pro Gly Arg Phe  Gly Pro Thr Cys Ala  Asp Glu Lys 
    1565                 1570                 1575             


Asn Pro  Cys Gln Pro Asn Pro  Cys His Gly Ser Ala  Pro Cys His 
    1580                 1585                 1590             


Val Leu  Ser Arg Gly Gly Ala  Lys Cys Ala Cys Pro  Leu Gly Arg 
    1595                 1600                 1605             


Ser Gly  Ser Phe Cys Glu Thr  Val Leu Glu Asn Ala  Gly Ser Arg 
    1610                 1615                 1620             


Pro Phe  Leu Ala Asp Phe Asn  Gly Phe Ser Tyr Leu  Glu Leu Lys 
    1625                 1630                 1635             


Gly Leu  His Thr Phe Glu Arg  Asp Leu Gly Glu Lys  Met Ala Leu 
    1640                 1645                 1650             


Glu Met  Val Phe Leu Ala Arg  Gly Pro Ser Gly Leu  Leu Leu Tyr 
    1655                 1660                 1665             


Asn Gly  Gln Lys Thr Asp Gly  Lys Gly Asp Phe Val  Ser Leu Ala 
    1670                 1675                 1680             


Leu His  Asn Arg His Leu Glu  Phe Arg Tyr Asp Leu  Gly Lys Gly 
    1685                 1690                 1695             


Ala Ala  Ile Ile Arg Ser Lys  Glu Pro Ile Ala Leu  Gly Thr Trp 
    1700                 1705                 1710             


Val Arg  Val Phe Leu Glu Arg  Asn Gly Arg Lys Gly  Ala Leu Gln 
    1715                 1720                 1725             


Val Gly  Asp Gly Pro Arg Val  Leu Gly Glu Ser Pro  Val Pro His 
    1730                 1735                 1740             


Thr Met  Leu Asn Leu Lys Glu  Pro Leu Tyr Val Gly  Gly Ala Pro 
    1745                 1750                 1755             


Asp Phe  Ser Lys Leu Ala Arg  Gly Ala Ala Val Ala  Ser Gly Phe 
    1760                 1765                 1770             


Asp Gly  Ala Ile Gln Leu Val  Ser Leu Arg Gly His  Gln Leu Leu 
    1775                 1780                 1785             


Thr Gln  Glu His Val Leu Arg  Ala Val Asp Val Ala  Pro Phe Ala 
    1790                 1795                 1800             


Gly His  Pro Cys Thr Gln Ala  Val Asp Asn Pro Cys  Leu Asn Gly 
    1805                 1810                 1815             


Gly Ser  Cys Ile Pro Arg Glu  Ala Thr Tyr Glu Cys  Leu Cys Pro 
    1820                 1825                 1830             


Gly Gly  Phe Ser Gly Leu His  Cys Glu Lys Gly Ile  Val Glu Lys 
    1835                 1840                 1845             


Ser Val  Gly Asp Leu Glu Thr  Leu Ala Phe Asp Gly  Arg Thr Tyr 
    1850                 1855                 1860             


Ile Glu  Tyr Leu Asn Ala Val  Thr Glu Ser Glu Lys  Ala Leu Gln 
    1865                 1870                 1875             


Ser Asn  His Phe Glu Leu Ser  Leu Arg Thr Glu Ala  Thr Gln Gly 
    1880                 1885                 1890             


Leu Val  Leu Trp Ile Gly Lys  Val Gly Glu Arg Ala  Asp Tyr Met 
    1895                 1900                 1905             


Ala Leu  Ala Ile Val Asp Gly  His Leu Gln Leu Ser  Tyr Asp Leu 
    1910                 1915                 1920             


Gly Ser  Gln Pro Val Val Leu  Arg Ser Thr Val Lys  Val Asn Thr 
    1925                 1930                 1935             


Asn Arg  Trp Leu Arg Val Arg  Ala His Arg Glu His  Arg Glu Gly 
    1940                 1945                 1950             


Ser Leu  Gln Val Gly Asn Glu  Ala Pro Val Thr Gly  Ser Ser Pro 
    1955                 1960                 1965             


Leu Gly  Ala Thr Gln Leu Asp  Thr Asp Gly Ala Leu  Trp Leu Gly 
    1970                 1975                 1980             


Gly Leu  Gln Lys Leu Pro Val  Gly Gln Ala Leu Pro  Lys Ala Tyr 
    1985                 1990                 1995             


Gly Thr  Gly Phe Val Gly Cys  Leu Arg Asp Val Val  Val Gly His 
    2000                 2005                 2010             


Arg Gln  Leu His Leu Leu Glu  Asp Ala Val Thr Lys  Pro Glu Leu 
    2015                 2020                 2025             


Arg Pro  Cys Pro Thr Leu 
    2030                 


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  10
gtcggctcgc ggcaaaaagc                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  11
gacatcaaag agaagctgtg                                                   20


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  12
actccatacc gataaaggaa g                                                 21


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  13
gagagaaaga aaccagagtg                                                   20


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  14
gtctagcagg ttcttgaaat c                                                 21


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  15
aattcaagat gcagaagctg                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  16
gaattttgag gtctctgctg                                                   20


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  17
ccagaaacat catcataacc g                                                 21


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  18
catcgccacc ttaatagttg                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  19
gtcaggctgg tcaccttctg                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  20
aactcttggc accatgaacc                                                   20


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  21
gctgggctcc ctggacattg ac                                                22


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  22
cctgggcctg gattctggtg at                                                22


<210>  23
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  23
ccagtgtgaa cttgattttg atgaa                                             25


<210>  24
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  24
aacataactt gggagacaga gacatct                                           27


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  25
catcgacgcc cagatgaaga                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  26
tggtgaacag ggtcccaaac                                                   20


<210>  27
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  27
cggaggagcg aacacctg                                                     18


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  28
gttggatcct caccctctgc                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  29
ttcgatggtc cttgtgaccc                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  30
agataggtgt gtgttgggcg                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  31
gtgcccatcg tcaacctgaa                                                   20


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  32
agttgaccct gggagccaga                                                   20


<210>  33
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  33
ccttctggca caagtctctt gg                                                22


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  34
tcgaagatga cactggcatc gg                                                22


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  35
tcgagcttga tctctcctat                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  36
tggtcccagg tcttacagaa                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Single strand DNA oligonucleotide

<400>  37
tggccggcag cgtttctgag                                                   20


<210>  38
<211>  4380
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Gly Trp Arg Ala Ala Gly Ala Leu Leu Leu Ala Leu Leu Leu His 
1               5                   10                  15      


Gly Arg Leu Leu Ala Val Thr His Gly Leu Arg Ala Tyr Asp Gly Leu 
            20                  25                  30          


Ser Leu Pro Glu Asp Ile Glu Thr Val Thr Ala Ser Gln Met Arg Trp 
        35                  40                  45              


Thr His Ser Tyr Leu Ser Asp Asp Glu Asp Met Leu Ala Asp Ser Ile 
    50                  55                  60                  


Ser Gly Asp Asp Leu Gly Ser Gly Asp Leu Gly Ser Gly Asp Phe Gln 
65                  70                  75                  80  


Met Val Tyr Phe Arg Ala Leu Val Asn Phe Thr Arg Ser Ile Glu Tyr 
                85                  90                  95      


Ser Pro Gln Leu Glu Asp Ala Gly Ser Arg Glu Phe Arg Glu Val Ser 
            100                 105                 110         


Glu Ala Val Val Asp Thr Leu Glu Ser Glu Tyr Leu Lys Ile Pro Gly 
        115                 120                 125             


Asp Gln Val Val Ser Val Val Phe Ile Lys Glu Leu Asp Gly Trp Val 
    130                 135                 140                 


Phe Val Glu Leu Asp Val Gly Ser Glu Gly Asn Ala Asp Gly Ala Gln 
145                 150                 155                 160 


Ile Gln Glu Met Leu Leu Arg Val Ile Ser Ser Gly Ser Val Ala Ser 
                165                 170                 175     


Tyr Val Thr Ser Pro Gln Gly Phe Gln Phe Arg Arg Leu Gly Thr Val 
            180                 185                 190         


Pro Gln Phe Pro Arg Ala Cys Thr Glu Ala Glu Phe Ala Cys His Ser 
        195                 200                 205             


Tyr Asn Glu Cys Val Ala Leu Glu Tyr Arg Cys Asp Arg Arg Pro Asp 
    210                 215                 220                 


Cys Arg Asp Met Ser Asp Glu Leu Asn Cys Glu Glu Pro Val Leu Gly 
225                 230                 235                 240 


Ile Ser Pro Thr Phe Ser Leu Leu Val Glu Thr Thr Ser Leu Pro Pro 
                245                 250                 255     


Arg Pro Glu Thr Thr Ile Met Arg Gln Pro Pro Val Thr His Ala Pro 
            260                 265                 270         


Gln Pro Leu Leu Pro Gly Ser Val Arg Pro Leu Pro Cys Gly Pro Gln 
        275                 280                 285             


Glu Ala Ala Cys Arg Asn Gly His Cys Ile Pro Arg Asp Tyr Leu Cys 
    290                 295                 300                 


Asp Gly Gln Glu Asp Cys Glu Asp Gly Ser Asp Glu Leu Asp Cys Gly 
305                 310                 315                 320 


Pro Pro Pro Pro Cys Glu Pro Asn Glu Phe Pro Cys Gly Asn Gly His 
                325                 330                 335     


Cys Ala Leu Lys Leu Trp Arg Cys Asp Gly Asp Phe Asp Cys Glu Asp 
            340                 345                 350         


Arg Thr Asp Glu Ala Asn Cys Pro Thr Lys Arg Pro Glu Glu Val Cys 
        355                 360                 365             


Gly Pro Thr Gln Phe Arg Cys Val Ser Thr Asn Met Cys Ile Pro Ala 
    370                 375                 380                 


Ser Phe His Cys Asp Glu Glu Ser Asp Cys Pro Asp Arg Ser Asp Glu 
385                 390                 395                 400 


Phe Gly Cys Met Pro Pro Gln Val Val Thr Pro Pro Arg Glu Ser Ile 
                405                 410                 415     


Gln Ala Ser Arg Gly Gln Thr Val Thr Phe Thr Cys Val Ala Ile Gly 
            420                 425                 430         


Val Pro Thr Pro Ile Ile Asn Trp Arg Leu Asn Trp Gly His Ile Pro 
        435                 440                 445             


Ser His Pro Arg Val Thr Val Thr Ser Glu Gly Gly Arg Gly Thr Leu 
    450                 455                 460                 


Ile Ile Arg Asp Val Lys Glu Ser Asp Gln Gly Ala Tyr Thr Cys Glu 
465                 470                 475                 480 


Ala Met Asn Ala Arg Gly Met Val Phe Gly Ile Pro Asp Gly Val Leu 
                485                 490                 495     


Glu Leu Val Pro Gln Arg Gly Pro Cys Pro Asp Gly His Phe Tyr Leu 
            500                 505                 510         


Glu His Ser Ala Ala Cys Leu Pro Cys Phe Cys Phe Gly Ile Thr Ser 
        515                 520                 525             


Val Cys Gln Ser Thr Arg Arg Phe Arg Asp Gln Ile Arg Leu Arg Phe 
    530                 535                 540                 


Asp Gln Pro Asp Asp Phe Lys Gly Val Asn Val Thr Met Pro Ala Gln 
545                 550                 555                 560 


Pro Gly Thr Pro Pro Leu Ser Ser Thr Gln Leu Gln Ile Asp Pro Ser 
                565                 570                 575     


Leu His Glu Phe Gln Leu Val Asp Leu Ser Arg Arg Phe Leu Val His 
            580                 585                 590         


Asp Ser Phe Trp Ala Leu Pro Glu Gln Phe Leu Gly Asn Lys Val Asp 
        595                 600                 605             


Ser Tyr Gly Gly Ser Leu Arg Tyr Asn Val Arg Tyr Glu Leu Ala Arg 
    610                 615                 620                 


Gly Met Leu Glu Pro Val Gln Arg Pro Asp Val Val Leu Met Gly Ala 
625                 630                 635                 640 


Gly Tyr Arg Leu Leu Ser Arg Gly His Thr Pro Thr Gln Pro Gly Ala 
                645                 650                 655     


Leu Asn Gln Arg Gln Val Gln Phe Ser Glu Glu His Trp Val His Glu 
            660                 665                 670         


Ser Gly Arg Pro Val Gln Arg Ala Glu Leu Leu Gln Val Leu Gln Ser 
        675                 680                 685             


Leu Glu Ala Val Leu Ile Gln Thr Val Tyr Asn Thr Lys Met Ala Ser 
    690                 695                 700                 


Val Gly Leu Ser Asp Ile Ala Met Asp Thr Thr Val Thr His Ala Thr 
705                 710                 715                 720 


Ser His Gly Arg Ala His Ser Val Glu Glu Cys Arg Cys Pro Ile Gly 
                725                 730                 735     


Tyr Ser Gly Leu Ser Cys Glu Ser Cys Asp Ala His Phe Thr Arg Val 
            740                 745                 750         


Pro Gly Gly Pro Tyr Leu Gly Thr Cys Ser Gly Cys Asn Cys Asn Gly 
        755                 760                 765             


His Ala Ser Ser Cys Asp Pro Val Tyr Gly His Cys Leu Asn Cys Gln 
    770                 775                 780                 


His Asn Thr Glu Gly Pro Gln Cys Asn Lys Cys Lys Ala Gly Phe Phe 
785                 790                 795                 800 


Gly Asp Ala Met Lys Ala Thr Ala Thr Ser Cys Arg Pro Cys Pro Cys 
                805                 810                 815     


Pro Tyr Ile Asp Ala Ser Arg Arg Phe Ser Asp Thr Cys Phe Leu Asp 
            820                 825                 830         


Thr Asp Gly Gln Ala Thr Cys Asp Ala Cys Ala Pro Gly Tyr Thr Gly 
        835                 840                 845             


Arg Arg Cys Glu Ser Cys Ala Pro Gly Tyr Glu Gly Asn Pro Ile Gln 
    850                 855                 860                 


Pro Gly Gly Lys Cys Arg Pro Val Asn Gln Glu Ile Val Arg Cys Asp 
865                 870                 875                 880 


Glu Arg Gly Ser Met Gly Thr Ser Gly Glu Ala Cys Arg Cys Lys Asn 
                885                 890                 895     


Asn Val Val Gly Arg Leu Cys Asn Glu Cys Ala Asp Gly Ser Phe His 
            900                 905                 910         


Leu Ser Thr Arg Asn Pro Asp Gly Cys Leu Lys Cys Phe Cys Met Gly 
        915                 920                 925             


Val Ser Arg His Cys Thr Ser Ser Ser Trp Ser Arg Ala Gln Leu His 
    930                 935                 940                 


Gly Ala Ser Glu Glu Pro Gly His Phe Ser Leu Thr Asn Ala Ala Ser 
945                 950                 955                 960 


Thr His Thr Thr Asn Glu Gly Ile Phe Ser Pro Thr Pro Gly Glu Leu 
                965                 970                 975     


Gly Phe Ser Ser Phe His Arg Leu Leu Ser Gly Pro Tyr Phe Trp Ser 
            980                 985                 990         


Leu Pro Ser Arg Phe Leu Gly Asp  Lys Val Thr Ser Tyr  Gly Gly Glu 
        995                 1000                 1005             


Leu Arg  Phe Thr Val Thr Gln  Arg Ser Gln Pro Gly  Ser Thr Pro 
    1010                 1015                 1020             


Leu His  Gly Gln Pro Leu Val  Val Leu Gln Gly Asn  Asn Ile Ile 
    1025                 1030                 1035             


Leu Glu  His His Val Ala Gln  Glu Pro Ser Pro Gly  Gln Pro Ser 
    1040                 1045                 1050             


Thr Phe  Ile Val Pro Phe Arg  Glu Gln Ala Trp Gln  Arg Pro Asp 
    1055                 1060                 1065             


Gly Gln  Pro Ala Thr Arg Glu  His Leu Leu Met Ala  Leu Ala Gly 
    1070                 1075                 1080             


Ile Asp  Thr Leu Leu Ile Arg  Ala Ser Tyr Ala Gln  Gln Pro Ala 
    1085                 1090                 1095             


Glu Ser  Arg Val Ser Gly Ile  Ser Met Asp Val Ala  Val Pro Glu 
    1100                 1105                 1110             


Glu Thr  Gly Gln Asp Pro Ala  Leu Glu Val Glu Gln  Cys Ser Cys 
    1115                 1120                 1125             


Pro Pro  Gly Tyr Arg Gly Pro  Ser Cys Gln Asp Cys  Asp Thr Gly 
    1130                 1135                 1140             


Tyr Thr  Arg Thr Pro Ser Gly  Leu Tyr Leu Gly Thr  Cys Glu Arg 
    1145                 1150                 1155             


Cys Ser  Cys His Gly His Ser  Glu Ala Cys Glu Pro  Glu Thr Gly 
    1160                 1165                 1170             


Ala Cys  Gln Gly Cys Gln His  His Thr Glu Gly Pro  Arg Cys Glu 
    1175                 1180                 1185             


Gln Cys  Gln Pro Gly Tyr Tyr  Gly Asp Ala Gln Arg  Gly Thr Pro 
    1190                 1195                 1200             


Gln Asp  Cys Gln Leu Cys Pro  Cys Tyr Gly Asp Pro  Ala Ala Gly 
    1205                 1210                 1215             


Gln Ala  Ala His Thr Cys Phe  Leu Asp Thr Asp Gly  His Pro Thr 
    1220                 1225                 1230             


Cys Asp  Ala Cys Ser Pro Gly  His Ser Gly Arg His  Cys Glu Arg 
    1235                 1240                 1245             


Cys Ala  Pro Gly Tyr Tyr Gly  Asn Pro Ser Gln Gly  Gln Pro Cys 
    1250                 1255                 1260             


Gln Arg  Asp Ser Gln Val Pro  Gly Pro Ile Gly Cys  Asn Cys Asp 
    1265                 1270                 1275             


Pro Gln  Gly Ser Val Ser Ser  Gln Cys Asp Ala Ala  Gly Gln Cys 
    1280                 1285                 1290             


Gln Cys  Lys Ala Gln Val Glu  Gly Leu Thr Cys Ser  His Cys Arg 
    1295                 1300                 1305             


Pro His  His Phe His Leu Ser  Ala Ser Asn Pro Asp  Gly Cys Leu 
    1310                 1315                 1320             


Pro Cys  Phe Cys Met Gly Ile  Thr Gln Gln Cys Ala  Ser Ser Ala 
    1325                 1330                 1335             


Tyr Thr  Arg His Leu Ile Ser  Thr His Phe Ala Pro  Gly Asp Phe 
    1340                 1345                 1350             


Gln Gly  Phe Ala Leu Val Asn  Pro Gln Arg Asn Ser  Arg Leu Thr 
    1355                 1360                 1365             


Gly Glu  Phe Thr Val Glu Pro  Val Pro Glu Gly Ala  Gln Leu Ser 
    1370                 1375                 1380             


Phe Gly  Asn Phe Ala Gln Leu  Gly His Glu Ser Phe  Tyr Trp Gln 
    1385                 1390                 1395             


Leu Pro  Glu Thr Tyr Gln Gly  Asp Lys Val Ala Ala  Tyr Gly Gly 
    1400                 1405                 1410             


Lys Leu  Arg Tyr Thr Leu Ser  Tyr Thr Ala Gly Pro  Gln Gly Ser 
    1415                 1420                 1425             


Pro Leu  Ser Asp Pro Asp Val  Gln Ile Thr Gly Asn  Asn Ile Met 
    1430                 1435                 1440             


Leu Val  Ala Ser Gln Pro Ala  Leu Gln Gly Pro Glu  Arg Arg Ser 
    1445                 1450                 1455             


Tyr Glu  Ile Met Phe Arg Glu  Glu Phe Trp Arg Arg  Pro Asp Gly 
    1460                 1465                 1470             


Gln Pro  Ala Thr Arg Glu His  Leu Leu Met Ala Leu  Ala Asp Leu 
    1475                 1480                 1485             


Asp Glu  Leu Leu Ile Arg Ala  Thr Phe Ser Ser Val  Pro Leu Ala 
    1490                 1495                 1500             


Ala Ser  Ile Ser Ala Val Ser  Leu Glu Val Ala Gln  Pro Gly Pro 
    1505                 1510                 1515             


Ser Asn  Arg Pro Arg Ala Leu  Glu Val Glu Glu Cys  Arg Cys Pro 
    1520                 1525                 1530             


Pro Gly  Tyr Ile Gly Leu Ser  Cys Gln Asp Cys Ala  Pro Gly Tyr 
    1535                 1540                 1545             


Thr Arg  Thr Gly Ser Gly Leu  Tyr Leu Gly His Cys  Glu Leu Cys 
    1550                 1555                 1560             


Glu Cys  Asn Gly His Ser Asp  Leu Cys His Pro Glu  Thr Gly Ala 
    1565                 1570                 1575             


Cys Ser  Gln Cys Gln His Asn  Ala Ala Gly Glu Phe  Cys Glu Leu 
    1580                 1585                 1590             


Cys Ala  Pro Gly Tyr Tyr Gly  Asp Ala Thr Ala Gly  Thr Pro Glu 
    1595                 1600                 1605             


Asp Cys  Gln Pro Cys Ala Cys  Pro Leu Thr Asn Pro  Glu Asn Met 
    1610                 1615                 1620             


Phe Ser  Arg Thr Cys Glu Ser  Leu Gly Ala Gly Gly  Tyr Arg Cys 
    1625                 1630                 1635             


Thr Ala  Cys Glu Pro Gly Tyr  Thr Gly Gln Tyr Cys  Glu Gln Cys 
    1640                 1645                 1650             


Gly Pro  Gly Tyr Val Gly Asn  Pro Ser Val Gln Gly  Gly Gln Cys 
    1655                 1660                 1665             


Leu Pro  Glu Thr Asn Gln Ala  Pro Leu Val Val Glu  Val His Pro 
    1670                 1675                 1680             


Ala Arg  Ser Ile Val Pro Gln  Gly Gly Ser His Ser  Leu Arg Cys 
    1685                 1690                 1695             


Gln Val  Ser Gly Ser Pro Pro  His Tyr Phe Tyr Trp  Ser Arg Glu 
    1700                 1705                 1710             


Asp Gly  Arg Pro Val Pro Ser  Gly Thr Gln Gln Arg  His Gln Gly 
    1715                 1720                 1725             


Ser Glu  Leu His Phe Pro Ser  Val Gln Pro Ser Asp  Ala Gly Val 
    1730                 1735                 1740             


Tyr Ile  Cys Thr Cys Arg Asn  Leu His Gln Ser Asn  Thr Ser Arg 
    1745                 1750                 1755             


Ala Glu  Leu Leu Val Thr Glu  Ala Pro Ser Lys Pro  Ile Thr Val 
    1760                 1765                 1770             


Thr Val  Glu Glu Gln Arg Ser  Gln Ser Val Arg Pro  Gly Ala Asp 
    1775                 1780                 1785             


Val Thr  Phe Ile Cys Thr Ala  Lys Ser Lys Ser Pro  Ala Tyr Thr 
    1790                 1795                 1800             


Leu Val  Trp Thr Arg Leu His  Asn Gly Lys Leu Pro  Thr Arg Ala 
    1805                 1810                 1815             


Met Asp  Phe Asn Gly Ile Leu  Thr Ile Arg Asn Val  Gln Leu Ser 
    1820                 1825                 1830             


Asp Ala  Gly Thr Tyr Val Cys  Thr Gly Ser Asn Met  Phe Ala Met 
    1835                 1840                 1845             


Asp Gln  Gly Thr Ala Thr Leu  His Val Gln Ala Ser  Gly Thr Leu 
    1850                 1855                 1860             


Ser Ala  Pro Val Val Ser Ile  His Pro Pro Gln Leu  Thr Val Gln 
    1865                 1870                 1875             


Pro Gly  Gln Leu Ala Glu Phe  Arg Cys Ser Ala Thr  Gly Ser Pro 
    1880                 1885                 1890             


Thr Pro  Thr Leu Glu Trp Thr  Gly Gly Pro Gly Gly  Gln Leu Pro 
    1895                 1900                 1905             


Ala Lys  Ala Gln Ile His Gly  Gly Ile Leu Arg Leu  Pro Ala Val 
    1910                 1915                 1920             


Glu Pro  Thr Asp Gln Ala Gln  Tyr Leu Cys Arg Ala  His Ser Ser 
    1925                 1930                 1935             


Ala Gly  Gln Gln Val Ala Arg  Ala Val Leu His Val  His Gly Gly 
    1940                 1945                 1950             


Gly Gly  Pro Arg Val Gln Val  Ser Pro Glu Arg Thr  Gln Val His 
    1955                 1960                 1965             


Ala Gly  Arg Thr Val Arg Leu  Tyr Cys Arg Ala Ala  Gly Val Pro 
    1970                 1975                 1980             


Ser Ala  Thr Ile Thr Trp Arg  Lys Glu Gly Gly Ser  Leu Pro Pro 
    1985                 1990                 1995             


Gln Ala  Arg Ser Glu Arg Thr  Asp Ile Ala Thr Leu  Leu Ile Pro 
    2000                 2005                 2010             


Ala Ile  Thr Thr Ala Asp Ala  Gly Phe Tyr Leu Cys  Val Ala Thr 
    2015                 2020                 2025             


Ser Pro  Ala Gly Thr Ala Gln  Ala Arg Ile Gln Val  Val Val Leu 
    2030                 2035                 2040             


Ser Ala  Ser Asp Ala Ser Pro  Pro Pro Val Lys Ile  Glu Ser Ser 
    2045                 2050                 2055             


Ser Pro  Ser Val Thr Glu Gly  Gln Thr Leu Asp Leu  Asn Cys Val 
    2060                 2065                 2070             


Val Ala  Gly Ser Ala His Ala  Gln Val Thr Trp Tyr  Arg Arg Gly 
    2075                 2080                 2085             


Gly Ser  Leu Pro Pro His Thr  Gln Val His Gly Ser  Arg Leu Arg 
    2090                 2095                 2100             


Leu Pro  Gln Val Ser Pro Ala  Asp Ser Gly Glu Tyr  Val Cys Arg 
    2105                 2110                 2115             


Val Glu  Asn Gly Ser Gly Pro  Lys Glu Ala Ser Ile  Thr Val Ser 
    2120                 2125                 2130             


Val Leu  His Gly Thr His Ser  Gly Pro Ser Tyr Thr  Pro Val Pro 
    2135                 2140                 2145             


Gly Ser  Thr Arg Pro Ile Arg  Ile Glu Pro Ser Ser  Ser His Val 
    2150                 2155                 2160             


Ala Glu  Gly Gln Thr Leu Asp  Leu Asn Cys Val Val  Pro Gly Gln 
    2165                 2170                 2175             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro 
    2180                 2185                 2190             


Ala Arg  His Gln Thr His Gly  Ser Leu Leu Arg Leu  His Gln Val 
    2195                 2200                 2205             


Thr Pro  Ala Asp Ser Gly Glu  Tyr Val Cys His Val  Val Gly Thr 
    2210                 2215                 2220             


Ser Gly  Pro Leu Glu Ala Ser  Val Leu Val Thr Ile  Glu Ala Ser 
    2225                 2230                 2235             


Val Ile  Pro Gly Pro Ile Pro  Pro Val Arg Ile Glu  Ser Ser Ser 
    2240                 2245                 2250             


Ser Thr  Val Ala Glu Gly Gln  Thr Leu Asp Leu Ser  Cys Val Val 
    2255                 2260                 2265             


Ala Gly  Gln Ala His Ala Gln  Val Thr Trp Tyr Lys  Arg Gly Gly 
    2270                 2275                 2280             


Ser Leu  Pro Ala Arg His Gln  Val Arg Gly Ser Arg  Leu Tyr Ile 
    2285                 2290                 2295             


Phe Gln  Ala Ser Pro Ala Asp  Ala Gly Gln Tyr Val  Cys Arg Ala 
    2300                 2305                 2310             


Ser Asn  Gly Met Glu Ala Ser  Ile Thr Val Thr Val  Thr Gly Thr 
    2315                 2320                 2325             


Gln Gly  Ala Asn Leu Ala Tyr  Pro Ala Gly Ser Thr  Gln Pro Ile 
    2330                 2335                 2340             


Arg Ile  Glu Pro Ser Ser Ser  Gln Val Ala Glu Gly  Gln Thr Leu 
    2345                 2350                 2355             


Asp Leu  Asn Cys Val Val Pro  Gly Gln Ser His Ala  Gln Val Thr 
    2360                 2365                 2370             


Trp His  Lys Arg Gly Gly Ser  Leu Pro Val Arg His  Gln Thr His 
    2375                 2380                 2385             


Gly Ser  Leu Leu Arg Leu Tyr  Gln Ala Ser Pro Ala  Asp Ser Gly 
    2390                 2395                 2400             


Glu Tyr  Val Cys Arg Val Leu  Gly Ser Ser Val Pro  Leu Glu Ala 
    2405                 2410                 2415             


Ser Val  Leu Val Thr Ile Glu  Pro Ala Gly Ser Val  Pro Ala Leu 
    2420                 2425                 2430             


Gly Val  Thr Pro Thr Val Arg  Ile Glu Ser Ser Ser  Ser Gln Val 
    2435                 2440                 2445             


Ala Glu  Gly Gln Thr Leu Asp  Leu Asn Cys Leu Val  Ala Gly Gln 
    2450                 2455                 2460             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Ser Leu Pro 
    2465                 2470                 2475             


Ala Arg  His Gln Val His Gly  Ser Arg Leu Arg Leu  Leu Gln Val 
    2480                 2485                 2490             


Thr Pro  Ala Asp Ser Gly Glu  Tyr Val Cys Arg Val  Val Gly Ser 
    2495                 2500                 2505             


Ser Gly  Thr Gln Glu Ala Ser  Val Leu Val Thr Ile  Gln Gln Arg 
    2510                 2515                 2520             


Leu Ser  Gly Ser His Ser Gln  Gly Val Ala Tyr Pro  Val Arg Ile 
    2525                 2530                 2535             


Glu Ser  Ser Ser Ala Ser Leu  Ala Asn Gly His Thr  Leu Asp Leu 
    2540                 2545                 2550             


Asn Cys  Leu Val Ala Ser Gln  Ala Pro His Thr Ile  Thr Trp Tyr 
    2555                 2560                 2565             


Lys Arg  Gly Gly Ser Leu Pro  Ser Arg His Gln Ile  Val Gly Ser 
    2570                 2575                 2580             


Arg Leu  Arg Ile Pro Gln Val  Thr Pro Ala Asp Ser  Gly Glu Tyr 
    2585                 2590                 2595             


Val Cys  His Val Ser Asn Gly  Ala Gly Ser Arg Glu  Thr Ser Leu 
    2600                 2605                 2610             


Ile Val  Thr Ile Gln Gly Ser  Gly Ser Ser His Val  Pro Ser Val 
    2615                 2620                 2625             


Ser Pro  Pro Ile Arg Ile Glu  Ser Ser Ser Pro Thr  Val Val Glu 
    2630                 2635                 2640             


Gly Gln  Thr Leu Asp Leu Asn  Cys Val Val Ala Arg  Gln Pro Gln 
    2645                 2650                 2655             


Ala Ile  Ile Thr Trp Tyr Lys  Arg Gly Gly Ser Leu  Pro Ser Arg 
    2660                 2665                 2670             


His Gln  Thr His Gly Ser His  Leu Arg Leu His Gln  Met Ser Val 
    2675                 2680                 2685             


Ala Asp  Ser Gly Glu Tyr Val  Cys Arg Ala Asn Asn  Asn Ile Asp 
    2690                 2695                 2700             


Ala Leu  Glu Ala Ser Ile Val  Ile Ser Val Ser Pro  Ser Ala Gly 
    2705                 2710                 2715             


Ser Pro  Ser Ala Pro Gly Ser  Ser Met Pro Ile Arg  Ile Glu Ser 
    2720                 2725                 2730             


Ser Ser  Ser His Val Ala Glu  Gly Glu Thr Leu Asp  Leu Asn Cys 
    2735                 2740                 2745             


Val Val  Pro Gly Gln Ala His  Ala Gln Val Thr Trp  His Lys Arg 
    2750                 2755                 2760             


Gly Gly  Ser Leu Pro Ser His  His Gln Thr Arg Gly  Ser Arg Leu 
    2765                 2770                 2775             


Arg Leu  His His Val Ser Pro  Ala Asp Ser Gly Glu  Tyr Val Cys 
    2780                 2785                 2790             


Arg Val  Met Gly Ser Ser Gly  Pro Leu Glu Ala Ser  Val Leu Val 
    2795                 2800                 2805             


Thr Ile  Glu Ala Ser Gly Ser  Ser Ala Val His Val  Pro Ala Pro 
    2810                 2815                 2820             


Gly Gly  Ala Pro Pro Ile Arg  Ile Glu Pro Ser Ser  Ser Arg Val 
    2825                 2830                 2835             


Ala Glu  Gly Gln Thr Leu Asp  Leu Lys Cys Val Val  Pro Gly Gln 
    2840                 2845                 2850             


Ala His  Ala Gln Val Thr Trp  His Lys Arg Gly Gly  Asn Leu Pro 
    2855                 2860                 2865             


Ala Arg  His Gln Val His Gly  Pro Leu Leu Arg Leu  Asn Gln Val 
    2870                 2875                 2880             


Ser Pro  Ala Asp Ser Gly Glu  Tyr Ser Cys Gln Val  Thr Gly Ser 
    2885                 2890                 2895             


Ser Gly  Thr Leu Glu Ala Ser  Val Leu Val Thr Ile  Glu Pro Ser 
    2900                 2905                 2910             


Ser Pro  Gly Pro Ile Pro Ala  Pro Gly Leu Ala Gln  Pro Ile Tyr 
    2915                 2920                 2925             


Ile Glu  Ala Ser Ser Ser His  Val Thr Glu Gly Gln  Thr Leu Asp 
    2930                 2935                 2940             


Leu Asn  Cys Val Val Pro Gly  Gln Ala His Ala Gln  Val Thr Trp 
    2945                 2950                 2955             


Tyr Lys  Arg Gly Gly Ser Leu  Pro Ala Arg His Gln  Thr His Gly 
    2960                 2965                 2970             


Ser Gln  Leu Arg Leu His Leu  Val Ser Pro Ala Asp  Ser Gly Glu 
    2975                 2980                 2985             


Tyr Val  Cys Arg Ala Ala Ser  Gly Pro Gly Pro Glu  Gln Glu Ala 
    2990                 2995                 3000             


Ser Phe  Thr Val Thr Val Pro  Pro Ser Glu Gly Ser  Ser Tyr Arg 
    3005                 3010                 3015             


Leu Arg  Ser Pro Val Ile Ser  Ile Asp Pro Pro Ser  Ser Thr Val 
    3020                 3025                 3030             


Gln Gln  Gly Gln Asp Ala Ser  Phe Lys Cys Leu Ile  His Asp Gly 
    3035                 3040                 3045             


Ala Ala  Pro Ile Ser Leu Glu  Trp Lys Thr Arg Asn  Gln Glu Leu 
    3050                 3055                 3060             


Glu Asp  Asn Val His Ile Ser  Pro Asn Gly Ser Ile  Ile Thr Ile 
    3065                 3070                 3075             


Val Gly  Thr Arg Pro Ser Asn  His Gly Thr Tyr Arg  Cys Val Ala 
    3080                 3085                 3090             


Ser Asn  Ala Tyr Gly Val Ala  Gln Ser Val Val Asn  Leu Ser Val 
    3095                 3100                 3105             


His Gly  Pro Pro Thr Val Ser  Val Leu Pro Glu Gly  Pro Val Trp 
    3110                 3115                 3120             


Val Lys  Val Gly Lys Ala Val  Thr Leu Glu Cys Val  Ser Ala Gly 
    3125                 3130                 3135             


Glu Pro  Arg Ser Ser Ala Arg  Trp Thr Arg Ile Ser  Ser Thr Pro 
    3140                 3145                 3150             


Ala Lys  Leu Glu Gln Arg Thr  Tyr Gly Leu Met Asp  Ser His Ala 
    3155                 3160                 3165             


Val Leu  Gln Ile Ser Ser Ala  Lys Pro Ser Asp Ala  Gly Thr Tyr 
    3170                 3175                 3180             


Val Cys  Leu Ala Gln Asn Ala  Leu Gly Thr Ala Gln  Lys Gln Val 
    3185                 3190                 3195             


Glu Val  Ile Val Asp Thr Gly  Ala Met Ala Pro Gly  Ala Pro Gln 
    3200                 3205                 3210             


Val Gln  Ala Glu Glu Ala Glu  Leu Thr Val Glu Ala  Gly His Thr 
    3215                 3220                 3225             


Ala Thr  Leu Arg Cys Ser Ala  Thr Gly Ser Pro Ala  Pro Thr Ile 
    3230                 3235                 3240             


His Trp  Ser Lys Leu Arg Ser  Pro Leu Pro Trp Gln  His Arg Leu 
    3245                 3250                 3255             


Glu Gly  Asp Thr Leu Ile Ile  Pro Arg Val Ala Gln  Gln Asp Ser 
    3260                 3265                 3270             


Gly Gln  Tyr Ile Cys Asn Ala  Thr Ser Pro Ala Gly  His Ala Glu 
    3275                 3280                 3285             


Ala Thr  Ile Ile Leu His Val  Glu Ser Pro Pro Tyr  Ala Thr Thr 
    3290                 3295                 3300             


Val Pro  Glu His Ala Ser Val  Gln Ala Gly Glu Thr  Val Gln Leu 
    3305                 3310                 3315             


Gln Cys  Leu Ala His Gly Thr  Pro Pro Leu Thr Phe  Gln Trp Ser 
    3320                 3325                 3330             


Arg Val  Gly Ser Ser Leu Pro  Gly Arg Ala Thr Ala  Arg Asn Glu 
    3335                 3340                 3345             


Leu Leu  His Phe Glu Arg Ala  Ala Pro Glu Asp Ser  Gly Arg Tyr 
    3350                 3355                 3360             


Arg Cys  Arg Val Thr Asn Lys  Val Gly Ser Ala Glu  Ala Phe Ala 
    3365                 3370                 3375             


Gln Leu  Leu Val Gln Gly Pro  Pro Gly Ser Leu Pro  Ala Thr Ser 
    3380                 3385                 3390             


Ile Pro  Ala Gly Ser Thr Pro  Thr Val Gln Val Thr  Pro Gln Leu 
    3395                 3400                 3405             


Glu Thr  Lys Ser Ile Gly Ala  Ser Val Glu Phe His  Cys Ala Val 
    3410                 3415                 3420             


Pro Ser  Asp Arg Gly Thr Gln  Leu Arg Trp Phe Lys  Glu Gly Gly 
    3425                 3430                 3435             


Gln Leu  Pro Pro Gly His Ser  Val Gln Asp Gly Val  Leu Arg Ile 
    3440                 3445                 3450             


Gln Asn  Leu Asp Gln Ser Cys  Gln Gly Thr Tyr Ile  Cys Gln Ala 
    3455                 3460                 3465             


His Gly  Pro Trp Gly Lys Ala  Gln Ala Ser Ala Gln  Leu Val Ile 
    3470                 3475                 3480             


Gln Ala  Leu Pro Ser Val Leu  Ile Asn Ile Arg Thr  Ser Val Gln 
    3485                 3490                 3495             


Thr Val  Val Val Gly His Ala  Val Glu Phe Glu Cys  Leu Ala Leu 
    3500                 3505                 3510             


Gly Asp  Pro Lys Pro Gln Val  Thr Trp Ser Lys Val  Gly Gly His 
    3515                 3520                 3525             


Leu Arg  Pro Gly Ile Val Gln  Ser Gly Gly Val Val  Arg Ile Ala 
    3530                 3535                 3540             


His Val  Glu Leu Ala Asp Ala  Gly Gln Tyr Arg Cys  Thr Ala Thr 
    3545                 3550                 3555             


Asn Ala  Ala Gly Thr Thr Gln  Ser His Val Leu Leu  Leu Val Gln 
    3560                 3565                 3570             


Ala Leu  Pro Gln Ile Ser Met  Pro Gln Glu Val Arg  Val Pro Ala 
    3575                 3580                 3585             


Gly Ser  Ala Ala Val Phe Pro  Cys Ile Ala Ser Gly  Tyr Pro Thr 
    3590                 3595                 3600             


Pro Asp  Ile Ser Trp Ser Lys  Leu Asp Gly Ser Leu  Pro Pro Asp 
    3605                 3610                 3615             


Ser Arg  Leu Glu Asn Asn Met  Leu Met Leu Pro Ser  Val Arg Pro 
    3620                 3625                 3630             


Gln Asp  Ala Gly Thr Tyr Val  Cys Thr Ala Thr Asn  Arg Gln Gly 
    3635                 3640                 3645             


Lys Val  Lys Ala Phe Ala His  Leu Gln Val Pro Glu  Arg Val Val 
    3650                 3655                 3660             


Pro Tyr  Phe Thr Gln Thr Pro  Tyr Ser Phe Leu Pro  Leu Pro Thr 
    3665                 3670                 3675             


Ile Lys  Asp Ala Tyr Arg Lys  Phe Glu Ile Lys Ile  Thr Phe Arg 
    3680                 3685                 3690             


Pro Asp  Ser Ala Asp Gly Met  Leu Leu Tyr Asn Gly  Gln Lys Arg 
    3695                 3700                 3705             


Val Pro  Gly Ser Pro Thr Asn  Leu Ala Asn Arg Gln  Pro Asp Phe 
    3710                 3715                 3720             


Ile Ser  Phe Gly Leu Val Gly  Gly Arg Pro Glu Phe  Arg Phe Asp 
    3725                 3730                 3735             


Ala Gly  Ser Gly Met Ala Thr  Ile Arg His Pro Thr  Pro Leu Ala 
    3740                 3745                 3750             


Leu Gly  His Phe His Thr Val  Thr Leu Leu Arg Ser  Leu Thr Gln 
    3755                 3760                 3765             


Gly Ser  Leu Ile Val Gly Asp  Leu Ala Pro Val Asn  Gly Thr Ser 
    3770                 3775                 3780             


Gln Gly  Lys Phe Gln Gly Leu  Asp Leu Asn Glu Glu  Leu Tyr Leu 
    3785                 3790                 3795             


Gly Gly  Tyr Pro Asp Tyr Gly  Ala Ile Pro Lys Ala  Gly Leu Ser 
    3800                 3805                 3810             


Ser Gly  Phe Ile Gly Cys Val  Arg Glu Leu Arg Ile  Gln Gly Glu 
    3815                 3820                 3825             


Glu Ile  Val Phe His Asp Leu  Asn Leu Thr Ala His  Gly Ile Ser 
    3830                 3835                 3840             


His Cys  Pro Thr Cys Arg Asp  Arg Pro Cys Gln Asn  Gly Gly Gln 
    3845                 3850                 3855             


Cys His  Asp Ser Glu Ser Ser  Ser Tyr Val Cys Val  Cys Pro Ala 
    3860                 3865                 3870             


Gly Phe  Thr Gly Ser Arg Cys  Glu His Ser Gln Ala  Leu His Cys 
    3875                 3880                 3885             


His Pro  Glu Ala Cys Gly Pro  Asp Ala Thr Cys Val  Asn Arg Pro 
    3890                 3895                 3900             


Asp Gly  Arg Gly Tyr Thr Cys  Arg Cys His Leu Gly  Arg Ser Gly 
    3905                 3910                 3915             


Leu Arg  Cys Glu Glu Gly Val  Thr Val Thr Thr Pro  Ser Leu Ser 
    3920                 3925                 3930             


Gly Ala  Gly Ser Tyr Leu Ala  Leu Pro Ala Leu Thr  Asn Thr His 
    3935                 3940                 3945             


His Glu  Leu Arg Leu Asp Val  Glu Phe Lys Pro Leu  Ala Pro Asp 
    3950                 3955                 3960             


Gly Val  Leu Leu Phe Ser Gly  Gly Lys Ser Gly Pro  Val Glu Asp 
    3965                 3970                 3975             


Phe Val  Ser Leu Ala Met Val  Gly Gly His Leu Glu  Phe Arg Tyr 
    3980                 3985                 3990             


Glu Leu  Gly Ser Gly Leu Ala  Val Leu Arg Ser Ala  Glu Pro Leu 
    3995                 4000                 4005             


Ala Leu  Gly Arg Trp His Arg  Val Ser Ala Glu Arg  Leu Asn Lys 
    4010                 4015                 4020             


Asp Gly  Ser Leu Arg Val Asn  Gly Gly Arg Pro Val  Leu Arg Ser 
    4025                 4030                 4035             


Ser Pro  Gly Lys Ser Gln Gly  Leu Asn Leu His Thr  Leu Leu Tyr 
    4040                 4045                 4050             


Leu Gly  Gly Val Glu Pro Ser  Val Pro Leu Ser Pro  Ala Thr Asn 
    4055                 4060                 4065             


Met Ser  Ala His Phe Arg Gly  Cys Val Gly Glu Val  Ser Val Asn 
    4070                 4075                 4080             


Gly Lys  Arg Leu Asp Leu Thr  Tyr Ser Phe Leu Gly  Ser Gln Gly 
    4085                 4090                 4095             


Ile Gly  Gln Cys Tyr Asp Ser  Ser Pro Cys Glu Arg  Gln Pro Cys 
    4100                 4105                 4110             


Gln His  Gly Ala Thr Cys Met  Pro Ala Gly Glu Tyr  Glu Phe Gln 
    4115                 4120                 4125             


Cys Leu  Cys Arg Asp Gly Phe  Lys Gly Asp Leu Cys  Glu His Glu 
    4130                 4135                 4140             


Glu Asn  Pro Cys Gln Leu Arg  Glu Pro Cys Leu His  Gly Gly Thr 
    4145                 4150                 4155             


Cys Gln  Gly Thr Arg Cys Leu  Cys Leu Pro Gly Phe  Ser Gly Pro 
    4160                 4165                 4170             


Arg Cys  Gln Gln Gly Ser Gly  His Gly Ile Ala Glu  Ser Asp Trp 
    4175                 4180                 4185             


His Leu  Glu Gly Ser Gly Gly  Asn Asp Ala Pro Gly  Gln Tyr Gly 
    4190                 4195                 4200             


Ala Tyr  Phe His Asp Asp Gly  Phe Leu Ala Phe Pro  Gly His Val 
    4205                 4210                 4215             


Phe Ser  Arg Ser Leu Pro Glu  Val Pro Glu Thr Ile  Glu Leu Glu 
    4220                 4225                 4230             


Val Arg  Thr Ser Thr Ala Ser  Gly Leu Leu Leu Trp  Gln Gly Val 
    4235                 4240                 4245             


Glu Val  Gly Glu Ala Gly Gln  Gly Lys Asp Phe Ile  Ser Leu Gly 
    4250                 4255                 4260             


Leu Gln  Asp Gly His Leu Val  Phe Arg Tyr Gln Leu  Gly Ser Gly 
    4265                 4270                 4275             


Glu Ala  Arg Leu Val Ser Glu  Asp Pro Ile Asn Asp  Gly Glu Trp 
    4280                 4285                 4290             


His Arg  Val Thr Ala Leu Arg  Glu Gly Arg Arg Gly  Ser Ile Gln 
    4295                 4300                 4305             


Val Asp  Gly Glu Glu Leu Val  Ser Gly Arg Ser Pro  Gly Pro Asn 
    4310                 4315                 4320             


Val Ala  Val Asn Ala Lys Gly  Ser Val Tyr Ile Gly  Gly Ala Pro 
    4325                 4330                 4335             


Asp Val  Ala Thr Leu Thr Gly  Gly Arg Phe Ser Ser  Gly Ile Thr 
    4340                 4345                 4350             


Gly Cys  Val Lys Asn Leu Val  Leu His Ser Ala Arg  Pro Gly Ala 
    4355                 4360                 4365             


Pro Pro  Pro Gln Pro Leu Asp  Leu Gln His Arg Ala  
    4370                 4375                 4380 


