                         SEQUENCE LISTING

<110>  GRIFOLS DIAGNOSTIC SOLUTIONS INC.
 
<120>  IMMUNOASSAYS AND ENGINEERED PROTEINS FOR MONITORING ANTIBODY 
       TREATMENTS TO THE IMMUNE CHECKPOINT INHIBITORS PD-1 AND PD-L1

<130>  62593080

<150>  US 62/593080
<151>  2017-11-30

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  2
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  3
<211>  20
<212>  PRT
<213>  Synthetic

<400>  3

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  4
<211>  4
<212>  PRT
<213>  Synthetic

<400>  4

Gly Gly Gly Ser 
1               


<210>  5
<211>  5
<212>  PRT
<213>  Synthetic

<400>  5

Gly Gly Gly Pro Ser 
1               5   


<210>  6
<211>  214
<212>  PRT
<213>  Synthetic

<400>  6

Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp 
1               5                   10                  15      


Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp 
            20                  25                  30          


Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp 
        35                  40                  45              


Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn 
    50                  55                  60                  


Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp 
65                  70                  75                  80  


Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro 
                85                  90                  95      


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala 
            100                 105                 110         


Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp 
        115                 120                 125             


Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile 
    130                 135                 140                 


Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn 
145                 150                 155                 160 


Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys 
                165                 170                 175     


Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys 
            180                 185                 190         


Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu 
        195                 200                 205             


Ser His Ser Pro Gly Ile 
    210                 


<210>  7
<211>  227
<212>  PRT
<213>  Synthetic

<400>  7

Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu 
1               5                   10                  15      


Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr 
            20                  25                  30          


Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser Lys 
        35                  40                  45              


Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val 
    50                  55                  60                  


His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
65                  70                  75                  80  


Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val 
        115                 120                 125             


Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser 
    130                 135                 140                 


Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu 
145                 150                 155                 160 


Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro 
                165                 170                 175     


Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val 
            180                 185                 190         


Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu 
        195                 200                 205             


His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His Ser 
    210                 215                 220                 


Pro Gly Ile 
225         


<210>  8
<211>  232
<212>  PRT
<213>  Synthetic

<400>  8

Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala 
1               5                   10                  15      


Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile 
            20                  25                  30          


Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
    50                  55                  60                  


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
65                  70                  75                  80  


Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln 
                85                  90                  95      


Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val 
        115                 120                 125             


Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr 
    130                 135                 140                 


Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu 
145                 150                 155                 160 


Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr 
                165                 170                 175     


Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 
            180                 185                 190         


Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr 
        195                 200                 205             


Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys 
    210                 215                 220                 


Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230         


<210>  9
<211>  27
<212>  PRT
<213>  Synthetic

<400>  9

Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys 
1               5                   10                  15      


Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25          


<210>  10
<211>  94
<212>  PRT
<213>  Synthetic

<400>  10

Gly Ser His Met Trp Lys Gln Ser Val Glu Leu Ala Lys Lys Asp Ser 
1               5                   10                  15      


Leu Tyr Lys Asp Ala Met Gln Tyr Ala Ser Glu Ser Lys Asp Thr Glu 
            20                  25                  30          


Leu Ala Glu Glu Leu Leu Gln Trp Phe Leu Gln Glu Glu Lys Arg Glu 
        35                  40                  45              


Cys Phe Gly Ala Cys Leu Phe Thr Cys Tyr Asp Leu Leu Arg Pro Asp 
    50                  55                  60                  


Val Val Leu Glu Leu Ala Trp Arg His Asn Ile Met Asp Phe Ala Met 
65                  70                  75                  80  


Pro Tyr Phe Ile Gln Val Met Lys Glu Tyr Leu Thr Lys Val 
                85                  90                  


<210>  11
<211>  40
<212>  PRT
<213>  Synthetic

<400>  11

Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
1               5                   10                  15      


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            20                  25                  30          


Ala Gln Ala Gly Lys Glu Pro Gly 
        35                  40  


<210>  12
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  12

Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
1               5                   10                  15      


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
            20                  25                  30          


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
        35                  40                  45              


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Ser Arg Phe Arg 
    50                  55                  60                  


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
65                  70                  75                  80  


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
                85                  90                  95      


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
            100                 105                 110         


Thr Glu Arg Arg Ala Glu 
        115             


<210>  13
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly 
1               5                   10                  15      


Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp 
            20                  25                  30          


Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile 
        35                  40                  45              


Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr 
    50                  55                  60                  


Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala 
65                  70                  75                  80  


Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg 
                85                  90                  95      


Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys 
            100                 105                 110         


Val Asn Ala Pro Tyr 
        115         


<210>  14
<211>  362
<212>  PRT
<213>  Synthetic

<400>  14

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val 
            20                  25                  30          


Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser 
        35                  40                  45              


Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr 
    50                  55                  60                  


Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp 
65                  70                  75                  80  


Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met 
                85                  90                  95      


Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly 
            100                 105                 110         


Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala 
        115                 120                 125             


Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro 
145                 150                 155                 160 


Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 
                165                 170                 175     


Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 
            180                 185                 190         


Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu 
        195                 200                 205             


Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met 
    210                 215                 220                 


His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser 
225                 230                 235                 240 


Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                245                 250                 255     


Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln 
            260                 265                 270         


Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe 
        275                 280                 285             


Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu 
    290                 295                 300                 


Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe 
305                 310                 315                 320 


Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn 
                325                 330                 335     


Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr 
            340                 345                 350         


Glu Lys Ser Leu Ser His Ser Pro Gly Ile 
        355                 360         


<210>  15
<211>  362
<212>  PRT
<213>  Synthetic

<400>  15

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val 
            20                  25                  30          


Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser 
        35                  40                  45              


Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr 
    50                  55                  60                  


Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp 
65                  70                  75                  80  


Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met 
                85                  90                  95      


Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly 
            100                 105                 110         


Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala 
        115                 120                 125             


Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Gly Gly Gly Pro Ser Gly 
    130                 135                 140                 


Gly Gly Pro Ser Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro 
145                 150                 155                 160 


Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 
                165                 170                 175     


Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 
            180                 185                 190         


Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu 
        195                 200                 205             


Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met 
    210                 215                 220                 


His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser 
225                 230                 235                 240 


Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
                245                 250                 255     


Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln 
            260                 265                 270         


Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe 
        275                 280                 285             


Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu 
    290                 295                 300                 


Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe 
305                 310                 315                 320 


Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn 
                325                 330                 335     


Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr 
            340                 345                 350         


Glu Lys Ser Leu Ser His Ser Pro Gly Ile 
        355                 360         


<210>  16
<211>  365
<212>  PRT
<213>  Synthetic

<400>  16

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val 
            20                  25                  30          


Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser 
        35                  40                  45              


Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr 
    50                  55                  60                  


Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp 
65                  70                  75                  80  


Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met 
                85                  90                  95      


Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly 
            100                 105                 110         


Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala 
        115                 120                 125             


Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val Pro Arg Asp Cys Gly 
    130                 135                 140                 


Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln 
            180                 185                 190         


Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln 
        195                 200                 205             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu 
    210                 215                 220                 


Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg 
225                 230                 235                 240 


Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro 
            260                 265                 270         


Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr 
        275                 280                 285             


Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln 
    290                 295                 300                 


Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly 
305                 310                 315                 320 


Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu 
                325                 330                 335     


Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn 
            340                 345                 350         


His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Ile 
        355                 360                 365 


<210>  17
<211>  370
<212>  PRT
<213>  Synthetic

<400>  17

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val 
            20                  25                  30          


Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser 
        35                  40                  45              


Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr 
    50                  55                  60                  


Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp 
65                  70                  75                  80  


Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met 
                85                  90                  95      


Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly 
            100                 105                 110         


Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala 
        115                 120                 125             


Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Pro Arg Gly Pro Thr Ile 
    130                 135                 140                 


Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly 
145                 150                 155                 160 


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
                165                 170                 175     


Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
            180                 185                 190         


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
        195                 200                 205             


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
    210                 215                 220                 


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
225                 230                 235                 240 


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu 
                245                 250                 255     


Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr 
            260                 265                 270         


Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu 
        275                 280                 285             


Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
    290                 295                 300                 


Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val 
305                 310                 315                 320 


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu 
                325                 330                 335     


Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His 
            340                 345                 350         


Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro 
        355                 360                 365             


Gly Lys 
    370 


<210>  18
<211>  171
<212>  PRT
<213>  Synthetic

<400>  18

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val 
            20                  25                  30          


Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser 
        35                  40                  45              


Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr 
    50                  55                  60                  


Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp 
65                  70                  75                  80  


Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met 
                85                  90                  95      


Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly 
            100                 105                 110         


Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala 
        115                 120                 125             


Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Gly Tyr Ile Pro Glu Ala 
    130                 135                 140                 


Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu 
145                 150                 155                 160 


Leu Ser Thr Phe Leu His His His His His His 
                165                 170     


<210>  19
<211>  238
<212>  PRT
<213>  Synthetic

<400>  19

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val 
            20                  25                  30          


Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser 
        35                  40                  45              


Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr 
    50                  55                  60                  


Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp 
65                  70                  75                  80  


Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met 
                85                  90                  95      


Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly 
            100                 105                 110         


Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala 
        115                 120                 125             


Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Gly Ser His Met Trp Lys 
    130                 135                 140                 


Gln Ser Val Glu Leu Ala Lys Lys Asp Ser Leu Tyr Lys Asp Ala Met 
145                 150                 155                 160 


Gln Tyr Ala Ser Glu Ser Lys Asp Thr Glu Leu Ala Glu Glu Leu Leu 
                165                 170                 175     


Gln Trp Phe Leu Gln Glu Glu Lys Arg Glu Cys Phe Gly Ala Cys Leu 
            180                 185                 190         


Phe Thr Cys Tyr Asp Leu Leu Arg Pro Asp Val Val Leu Glu Leu Ala 
        195                 200                 205             


Trp Arg His Asn Ile Met Asp Phe Ala Met Pro Tyr Phe Ile Gln Val 
    210                 215                 220                 


Met Lys Glu Tyr Leu Thr Lys Val His His His His His His 
225                 230                 235             


<210>  20
<211>  185
<212>  PRT
<213>  Synthetic

<400>  20

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val 
            20                  25                  30          


Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser 
        35                  40                  45              


Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr 
    50                  55                  60                  


Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp 
65                  70                  75                  80  


Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met 
                85                  90                  95      


Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly 
            100                 105                 110         


Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala 
        115                 120                 125             


Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Lys Pro Leu Asp Gly Glu 
    130                 135                 140                 


Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg 
145                 150                 155                 160 


Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu 
                165                 170                 175     


Pro Gly His His His His His His His 
            180                 185 


<210>  21
<211>  361
<212>  PRT
<213>  Synthetic

<400>  21

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val 
            20                  25                  30          


Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu 
        35                  40                  45              


Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp 
    50                  55                  60                  


Lys Asn Ile Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln 
65                  70                  75                  80  


His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser 
                85                  90                  95      


Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala 
            100                 105                 110         


Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg 
        115                 120                 125             


Ile Thr Val Lys Val Asn Ala Pro Tyr Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
            180                 185                 190         


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
        195                 200                 205             


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
225                 230                 235                 240 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
                245                 250                 255     


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
            260                 265                 270         


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
        275                 280                 285             


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
    290                 295                 300                 


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
305                 310                 315                 320 


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
                325                 330                 335     


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
            340                 345                 350         


Lys Ser Leu Ser His Ser Pro Gly Ile 
        355                 360     


<210>  22
<211>  361
<212>  PRT
<213>  Synthetic

<400>  22

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val 
            20                  25                  30          


Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu 
        35                  40                  45              


Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp 
    50                  55                  60                  


Lys Asn Ile Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln 
65                  70                  75                  80  


His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser 
                85                  90                  95      


Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala 
            100                 105                 110         


Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg 
        115                 120                 125             


Ile Thr Val Lys Val Asn Ala Pro Tyr Gly Gly Gly Pro Ser Gly Gly 
    130                 135                 140                 


Gly Pro Ser Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
145                 150                 155                 160 


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
                165                 170                 175     


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
            180                 185                 190         


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
        195                 200                 205             


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
    210                 215                 220                 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
225                 230                 235                 240 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
                245                 250                 255     


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
            260                 265                 270         


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
        275                 280                 285             


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
    290                 295                 300                 


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
305                 310                 315                 320 


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
                325                 330                 335     


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
            340                 345                 350         


Lys Ser Leu Ser His Ser Pro Gly Ile 
        355                 360     


<210>  23
<211>  364
<212>  PRT
<213>  Synthetic

<400>  23

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val 
            20                  25                  30          


Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu 
        35                  40                  45              


Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp 
    50                  55                  60                  


Lys Asn Ile Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln 
65                  70                  75                  80  


His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser 
                85                  90                  95      


Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala 
            100                 105                 110         


Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg 
        115                 120                 125             


Ile Thr Val Lys Val Asn Ala Pro Tyr Val Pro Arg Asp Cys Gly Cys 
    130                 135                 140                 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
145                 150                 155                 160 


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
                165                 170                 175     


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
            180                 185                 190         


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
        195                 200                 205             


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
    210                 215                 220                 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
225                 230                 235                 240 


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                245                 250                 255     


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
            260                 265                 270         


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
        275                 280                 285             


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
    290                 295                 300                 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
305                 310                 315                 320 


Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
                325                 330                 335     


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
            340                 345                 350         


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Ile 
        355                 360                 


<210>  24
<211>  369
<212>  PRT
<213>  Synthetic

<400>  24

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val 
            20                  25                  30          


Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu 
        35                  40                  45              


Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp 
    50                  55                  60                  


Lys Asn Ile Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln 
65                  70                  75                  80  


His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser 
                85                  90                  95      


Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala 
            100                 105                 110         


Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg 
        115                 120                 125             


Ile Thr Val Lys Val Asn Ala Pro Tyr Pro Arg Gly Pro Thr Ile Lys 
    130                 135                 140                 


Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro 
145                 150                 155                 160 


Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser 
                165                 170                 175     


Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp 
            180                 185                 190         


Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr 
        195                 200                 205             


Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val 
    210                 215                 220                 


Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu 
225                 230                 235                 240 


Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg 
                245                 250                 255     


Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val 
            260                 265                 270         


Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr 
        275                 280                 285             


Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr 
    290                 295                 300                 


Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu 
305                 310                 315                 320 


Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys 
                325                 330                 335     


Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu 
            340                 345                 350         


Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly 
        355                 360                 365             


Lys 
    


<210>  25
<211>  170
<212>  PRT
<213>  Synthetic

<400>  25

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val 
            20                  25                  30          


Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu 
        35                  40                  45              


Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp 
    50                  55                  60                  


Lys Asn Ile Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln 
65                  70                  75                  80  


His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser 
                85                  90                  95      


Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala 
            100                 105                 110         


Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg 
        115                 120                 125             


Ile Thr Val Lys Val Asn Ala Pro Tyr Gly Tyr Ile Pro Glu Ala Pro 
    130                 135                 140                 


Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu 
145                 150                 155                 160 


Ser Thr Phe Leu His His His His His His 
                165                 170 


<210>  26
<211>  237
<212>  PRT
<213>  Synthetic

<400>  26

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val 
            20                  25                  30          


Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu 
        35                  40                  45              


Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp 
    50                  55                  60                  


Lys Asn Ile Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln 
65                  70                  75                  80  


His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser 
                85                  90                  95      


Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala 
            100                 105                 110         


Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg 
        115                 120                 125             


Ile Thr Val Lys Val Asn Ala Pro Tyr Gly Ser His Met Trp Lys Gln 
    130                 135                 140                 


Ser Val Glu Leu Ala Lys Lys Asp Ser Leu Tyr Lys Asp Ala Met Gln 
145                 150                 155                 160 


Tyr Ala Ser Glu Ser Lys Asp Thr Glu Leu Ala Glu Glu Leu Leu Gln 
                165                 170                 175     


Trp Phe Leu Gln Glu Glu Lys Arg Glu Cys Phe Gly Ala Cys Leu Phe 
            180                 185                 190         


Thr Cys Tyr Asp Leu Leu Arg Pro Asp Val Val Leu Glu Leu Ala Trp 
        195                 200                 205             


Arg His Asn Ile Met Asp Phe Ala Met Pro Tyr Phe Ile Gln Val Met 
    210                 215                 220                 


Lys Glu Tyr Leu Thr Lys Val His His His His His His 
225                 230                 235         


<210>  27
<211>  184
<212>  PRT
<213>  Synthetic

<400>  27

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val 
            20                  25                  30          


Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu 
        35                  40                  45              


Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp 
    50                  55                  60                  


Lys Asn Ile Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln 
65                  70                  75                  80  


His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser 
                85                  90                  95      


Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala 
            100                 105                 110         


Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg 
        115                 120                 125             


Ile Thr Val Lys Val Asn Ala Pro Tyr Lys Pro Leu Asp Gly Glu Tyr 
    130                 135                 140                 


Phe Thr Leu Gln Ile Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu 
145                 150                 155                 160 


Leu Asn Glu Ala Leu Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro 
                165                 170                 175     


Gly His His His His His His His 
            180                 


<210>  28
<211>  217
<212>  PRT
<213>  Synthetic

<400>  28

Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        35                  40                  45              


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
    50                  55                  60                  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
65                  70                  75                  80  


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
                85                  90                  95      


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
            100                 105                 110         


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
        115                 120                 125             


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
    130                 135                 140                 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
145                 150                 155                 160 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
                165                 170                 175     


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
            180                 185                 190         


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
        195                 200                 205             


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    210                 215         


<210>  29
<211>  195
<212>  PRT
<213>  Synthetic

<400>  29

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val 
            20                  25                  30          


Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser 
        35                  40                  45              


Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr 
    50                  55                  60                  


Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp 
65                  70                  75                  80  


Ser Arg Phe Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met 
                85                  90                  95      


Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly 
            100                 105                 110         


Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala 
        115                 120                 125             


Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Gly Gly Gly Pro Ser Gly 
    130                 135                 140                 


Gly Gly Pro Ser Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile 
145                 150                 155                 160 


Arg Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu 
                165                 170                 175     


Glu Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly His His His His 
            180                 185                 190         


His His His 
        195 


<210>  30
<211>  194
<212>  PRT
<213>  Synthetic

<400>  30

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val 
            20                  25                  30          


Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu 
        35                  40                  45              


Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp 
    50                  55                  60                  


Lys Asn Ile Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln 
65                  70                  75                  80  


His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser 
                85                  90                  95      


Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala 
            100                 105                 110         


Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg 
        115                 120                 125             


Ile Thr Val Lys Val Asn Ala Pro Tyr Gly Gly Gly Pro Ser Gly Gly 
    130                 135                 140                 


Gly Pro Ser Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg 
145                 150                 155                 160 


Gly Arg Glu Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu 
                165                 170                 175     


Leu Lys Asp Ala Gln Ala Gly Lys Glu Pro Gly His His His His His 
            180                 185                 190         


His His 
        


<210>  31
<211>  7
<212>  PRT
<213>  Synthetic

<400>  31

His His His His His His His 
1               5           


