                         SEQUENCE LISTING

<110>  Bayer Intellectual Property GmbH
 
<120>  ILDR2 antagonists, and combinations thereof

<130>  BHC171086FC

<150>  US62/592913
<151>  2017-11-30

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  59-08.B02 BAY1905254 HCDR1

<400>  1

Ser Tyr Ala Ile Ser 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  59-08.B02 BAY1905254 HCDR2

<400>  2

Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  59-08.B02 BAY1905254 HCDR3

<400>  3

Ala Arg Gly Arg Leu Pro Tyr Gly Asp Phe Trp Asp Ser 
1               5                   10              


<210>  4
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  59-08.B02 BAY1905254 LCDR1

<400>  4

Arg Ser Ser Gln Ser Leu Leu Tyr Ser Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  59-08.B02 BAY1905254 LCDR2

<400>  5

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  59-08.B02 BAY1905254 LCDR3

<400>  6

Met Gln Ala Leu Gln Thr Pro Leu Thr 
1               5                   


<210>  7
<211>  120
<212>  PRT
<213>  Artificial

<220>
<223>  59-08.B02 heavy chain VD| BAY1905254

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Leu Pro Tyr Gly Asp Phe Trp Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  59-08.B02-light chain VD| BAY1905254

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105                 110         


<210>  9
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  61-02.C05 heavy chain VD

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Ser Ser Gly Gly Ser Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Lys Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Phe Val Gly Val Leu Pro Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120     


<210>  10
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  61-02.C05 light chain VD

<400>  10

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Thr Asn Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Leu Glu Ser Gly Val Pro Pro Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Gly Arg Tyr Tyr Cys Gln Gln Tyr His Ile Pro Pro Pro 
                85                  90                  95      


Ser Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  115
<212>  PRT
<213>  Artificial

<220>
<223>  56-02.E08 heavy chain VD

<400>  11

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Tyr Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Glu Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Gly Glu Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  12
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  56-02.E08 light chain VD

<400>  12

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ala 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Thr Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  13
<211>  131
<212>  PRT
<213>  artificial

<220>
<223>  74.15.G09 heavy chain VD

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Ser Pro Ser Val Gly Leu Gly Ser Tyr Tyr Asp Phe Trp 
            100                 105                 110         


Ser Gly Leu Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  14
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  74.15.G09 light chain VD

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Thr Gly Gln Arg Val Glu Asn Leu 
            20                  25                  30          


Phe Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Leu Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asp Ser Gly 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  15
<211>  125
<212>  PRT
<213>  Artificial

<220>
<223>  56.02.E10 heavy chain VD

<400>  15

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Leu 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Ile Ala Ala Pro Gly Ser Gly Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  16
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  56.02.E10 light chain VD

<400>  16

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Thr Thr Thr Asp Val Gly Arg Tyr 
            20                  25                  30          


Thr Leu Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Phe Glu Val Asn Lys Arg Pro Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Phe Cys Cys Ser Tyr Thr Gly Thr 
                85                  90                  95      


Thr Val Ile Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CPG Oligo nucleotide ODN 1826

<400>  17
tccatgacgt tcctgacgtt                                                   20


<210>  18
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  61-02.C05 HCDR1

<400>  18

Ser Tyr Ala Met Ser 
1               5   


<210>  19
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  61-02.C05 HCDR2

<400>  19

Gly Ile Ser Ser Ser Gly Gly Ser Thr Gln Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  20
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  61-02.C05 HCDR3

<400>  20

Asp Phe Val Gly Val Leu Pro Asp Ala Phe Asp Ile 
1               5                   10          


<210>  21
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  61-02.C05 LCDR1

<400>  21

Gln Ala Ser Gln Asp Thr Asn Lys Tyr Leu Asn 
1               5                   10      


<210>  22
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  61-02.C05 LCDR2

<400>  22

Gly Ala Ser Thr Leu Glu Ser 
1               5           


<210>  23
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  61-02.C05 LCDR3

<400>  23

Gln Gln Tyr His Ile Pro Pro Pro Ser 
1               5                   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  56-02.E08 HCDR1

<400>  24

Thr Tyr Trp Ile Gly 
1               5   


<210>  25
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  56-02.E08 HCDR2

<400>  25

Ile Ile Tyr Pro Gly Asp Tyr Asp Thr Arg Tyr Ser Pro Ser Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  56-02.E08 HCDR3

<400>  26

Ala Ile Gly Glu Pro Phe Asp Tyr 
1               5               


<210>  27
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  56-02.E08 LCDR1

<400>  27

Arg Ser Ser Gln Ser Leu Leu His Ala Asn Gly Tyr Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  28
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  56-02.E08 LCDR2

<400>  28

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  29
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  56-02.E08 LCDR3

<400>  29

Met Gln Ala Leu Gln Thr Pro Leu Thr 
1               5                   


<210>  30
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  74.15.G09 HCDR1

<400>  30

Ser Tyr Gly Met His 
1               5   


<210>  31
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  74.15.G09 HCDR2

<400>  31

Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  74.15.G09 HCDR3

<400>  32

Ala Lys Glu Ser Pro Ser Val Gly Leu Gly Ser Tyr Tyr Asp Phe Trp 
1               5                   10                  15      


Ser Gly Leu Tyr Gly Met Asp Val 
            20                  


<210>  33
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  74.15.G09 LCDR1

<400>  33

Arg Thr Gly Gln Arg Val Glu Asn Leu Phe Ile Ala 
1               5                   10          


<210>  34
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  74.15.G09 LCDR2

<400>  34

Gly Ala Ser Asn Arg Ala Thr 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  74.15.G09 LCDR3

<400>  35

Gln Gln Tyr Asp Asp Ser Gly Ile Thr 
1               5                   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  56.02.E10 HCDR1

<400>  36

Asn Tyr Gly Met His 
1               5   


<210>  37
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  56.02.E10 HCDR2

<400>  37

Phe Ile Arg Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  38
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  56.02.E10 HCDR3

<400>  38

Glu Gly Ile Ala Ala Pro Gly Ser Gly Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  39
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  56.02.E10 LCDR1

<400>  39

Ser Gly Thr Thr Thr Asp Val Gly Arg Tyr Thr Leu Val Ser 
1               5                   10                  


<210>  40
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  56.02.E10 LCDR2

<400>  40

Glu Val Asn Lys Arg Pro Ser 
1               5           


<210>  41
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  56.02.E10 LCDR3

<400>  41

Cys Ser Tyr Thr Gly Thr Thr Val Ile 
1               5                   


<210>  42
<211>  445
<212>  PRT
<213>  Artificial

<220>
<223>  59-08.B02 heavy chain BAY1905254

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Arg Leu Pro Tyr Gly Asp Phe Trp Asp Ser Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
    210                 215                 220                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445 


<210>  43
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  59-08.B02-light chain BAY1905254

<400>  43

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  44
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  61-02.C05 heavy chain

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Ser Ser Gly Gly Ser Thr Gln Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Lys Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Phe Val Gly Val Leu Pro Asp Ala Phe Asp Ile Trp Gly 
            100                 105                 110         


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  45
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  61-02.C05 light chain

<400>  45

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Thr Asn Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Leu Glu Ser Gly Val Pro Pro Arg Phe Ser Ala 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Gly Arg Tyr Tyr Cys Gln Gln Tyr His Ile Pro Pro Pro 
                85                  90                  95      


Ser Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  46
<211>  440
<212>  PRT
<213>  Artificial

<220>
<223>  56-02.E08 heavy chain

<400>  46

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Ile Gly Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Tyr Pro Gly Asp Tyr Asp Thr Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Glu Ala Ser Asp Ser Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Gly Glu Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
            180                 185                 190         


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
    210                 215                 220                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
            260                 265                 270         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
305                 310                 315                 320 


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
                325                 330                 335     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
            340                 345                 350         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        355                 360                 365             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    370                 375                 380                 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
385                 390                 395                 400 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                405                 410                 415     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            420                 425                 430         


Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440 


<210>  47
<211>  219
<212>  PRT
<213>  Artificial

<220>
<223>  56-02.E08 light chain

<400>  47

Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ala 
            20                  25                  30          


Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Thr Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 
                85                  90                  95      


Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  48
<211>  456
<212>  PRT
<213>  Artificial

<220>
<223>  74.15.G09 heavy chain

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Ser Pro Ser Val Gly Leu Gly Ser Tyr Tyr Asp Phe Trp 
            100                 105                 110         


Ser Gly Leu Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
        115                 120                 125             


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
    130                 135                 140                 


Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
                165                 170                 175     


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
            180                 185                 190         


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly 
        195                 200                 205             


Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys 
    210                 215                 220                 


Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys 
225                 230                 235                 240 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455     


<210>  49
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  74.15.G09 light chain

<400>  49

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Arg Thr Gly Gln Arg Val Glu Asn Leu 
            20                  25                  30          


Phe Ile Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Leu Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Ser Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asp Ser Gly 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  50
<211>  450
<212>  PRT
<213>  Artificial

<220>
<223>  56.02.E10 heavy chain

<400>  50

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Leu 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Ile Ala Ala Pro Gly Ser Gly Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
        115                 120                 125             


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
    130                 135                 140                 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
                165                 170                 175     


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
            180                 185                 190         


Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys 
        195                 200                 205             


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu 
    210                 215                 220                 


Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly 
    450 


<210>  51
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  56.02.E10 light chain

<400>  51

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Thr Thr Thr Asp Val Gly Arg Tyr 
            20                  25                  30          


Thr Leu Val Ser Trp Tyr Gln His His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Phe Glu Val Asn Lys Arg Pro Ser Gly Val Ser Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Asp Tyr Phe Cys Cys Ser Tyr Thr Gly Thr 
                85                  90                  95      


Thr Val Ile Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


