                         SEQUENCE LISTING

<110>  University of Canberra
 
<120>  IMMUNOPOTENTIATING COMPOSITIONS AND USES THEREFOR

<130>  35519717/vpa

<140>  Unassigned
<141>  2018-11-27

<150>  AU2017904811
<151>  2017-11-29

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  852
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Ser Gly Lys Lys Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Thr Gly Thr Glu Ala Gly Pro Gly Thr Ala Gly Gly Ser Glu 
            20                  25                  30          


Asn Gly Ser Glu Val Ala Ala Gln Pro Ala Gly Leu Ser Gly Pro Ala 
        35                  40                  45              


Glu Val Gly Pro Gly Ala Val Gly Glu Arg Thr Pro Arg Lys Lys Glu 
    50                  55                  60                  


Pro Pro Arg Ala Ser Pro Pro Gly Gly Leu Ala Glu Pro Pro Gly Ser 
65                  70                  75                  80  


Ala Gly Pro Gln Ala Gly Pro Thr Val Val Pro Gly Ser Ala Thr Pro 
                85                  90                  95      


Met Glu Thr Gly Ile Ala Glu Thr Pro Glu Gly Arg Arg Thr Ser Arg 
            100                 105                 110         


Arg Lys Arg Ala Lys Val Glu Tyr Arg Glu Met Asp Glu Ser Leu Ala 
        115                 120                 125             


Asn Leu Ser Glu Asp Glu Tyr Tyr Ser Glu Glu Glu Arg Asn Ala Lys 
    130                 135                 140                 


Ala Glu Lys Glu Lys Lys Leu Pro Pro Pro Pro Pro Gln Ala Pro Pro 
145                 150                 155                 160 


Glu Glu Glu Asn Glu Ser Glu Pro Glu Glu Pro Ser Gly Val Glu Gly 
                165                 170                 175     


Ala Ala Phe Gln Ser Arg Leu Pro His Asp Arg Met Thr Ser Gln Glu 
            180                 185                 190         


Ala Ala Cys Phe Pro Asp Ile Ile Ser Gly Pro Gln Gln Thr Gln Lys 
        195                 200                 205             


Val Phe Leu Phe Ile Arg Asn Arg Thr Leu Gln Leu Trp Leu Asp Asn 
    210                 215                 220                 


Pro Lys Ile Gln Leu Thr Phe Glu Ala Thr Leu Gln Gln Leu Glu Ala 
225                 230                 235                 240 


Pro Tyr Asn Ser Asp Thr Val Leu Val His Arg Val His Ser Tyr Leu 
                245                 250                 255     


Glu Arg His Gly Leu Ile Asn Phe Gly Ile Tyr Lys Arg Ile Lys Pro 
            260                 265                 270         


Leu Pro Thr Lys Lys Thr Gly Lys Val Ile Ile Ile Gly Ser Gly Val 
        275                 280                 285             


Ser Gly Leu Ala Ala Ala Arg Gln Leu Gln Ser Phe Gly Met Asp Val 
    290                 295                 300                 


Thr Leu Leu Glu Ala Arg Asp Arg Val Gly Gly Arg Val Ala Thr Phe 
305                 310                 315                 320 


Arg Lys Gly Asn Tyr Val Ala Asp Leu Gly Ala Met Val Val Thr Gly 
                325                 330                 335     


Leu Gly Gly Asn Pro Met Ala Val Val Ser Lys Gln Val Asn Met Glu 
            340                 345                 350         


Leu Ala Lys Ile Lys Gln Lys Cys Pro Leu Tyr Glu Ala Asn Gly Gln 
        355                 360                 365             


Ala Val Pro Lys Glu Lys Asp Glu Met Val Glu Gln Glu Phe Asn Arg 
    370                 375                 380                 


Leu Leu Glu Ala Thr Ser Tyr Leu Ser His Gln Leu Asp Phe Asn Val 
385                 390                 395                 400 


Leu Asn Asn Lys Pro Val Ser Leu Gly Gln Ala Leu Glu Val Val Ile 
                405                 410                 415     


Gln Leu Gln Glu Lys His Val Lys Asp Glu Gln Ile Glu His Trp Lys 
            420                 425                 430         


Lys Ile Val Lys Thr Gln Glu Glu Leu Lys Glu Leu Leu Asn Lys Met 
        435                 440                 445             


Val Asn Leu Lys Glu Lys Ile Lys Glu Leu His Gln Gln Tyr Lys Glu 
    450                 455                 460                 


Ala Ser Glu Val Lys Pro Pro Arg Asp Ile Thr Ala Glu Phe Leu Val 
465                 470                 475                 480 


Lys Ser Lys His Arg Asp Leu Thr Ala Leu Cys Lys Glu Tyr Asp Glu 
                485                 490                 495     


Leu Ala Glu Thr Gln Gly Lys Leu Glu Glu Lys Leu Gln Glu Leu Glu 
            500                 505                 510         


Ala Asn Pro Pro Ser Asp Val Tyr Leu Ser Ser Arg Asp Arg Gln Ile 
        515                 520                 525             


Leu Asp Trp His Phe Ala Asn Leu Glu Phe Ala Asn Ala Thr Pro Leu 
    530                 535                 540                 


Ser Thr Leu Ser Leu Lys His Trp Asp Gln Asp Asp Asp Phe Glu Phe 
545                 550                 555                 560 


Thr Gly Ser His Leu Thr Val Arg Asn Gly Tyr Ser Cys Val Pro Val 
                565                 570                 575     


Ala Leu Ala Glu Gly Leu Asp Ile Lys Leu Asn Thr Ala Val Arg Gln 
            580                 585                 590         


Val Arg Tyr Thr Ala Ser Gly Cys Glu Val Ile Ala Val Asn Thr Arg 
        595                 600                 605             


Ser Thr Ser Gln Thr Phe Ile Tyr Lys Cys Asp Ala Val Leu Cys Thr 
    610                 615                 620                 


Leu Pro Leu Gly Val Leu Lys Gln Gln Pro Pro Ala Val Gln Phe Val 
625                 630                 635                 640 


Pro Pro Leu Pro Glu Trp Lys Thr Ser Ala Val Gln Arg Met Gly Phe 
                645                 650                 655     


Gly Asn Leu Asn Lys Val Val Leu Cys Phe Asp Arg Val Phe Trp Asp 
            660                 665                 670         


Pro Ser Val Asn Leu Phe Gly His Val Gly Ser Thr Thr Ala Ser Arg 
        675                 680                 685             


Gly Glu Leu Phe Leu Phe Trp Asn Leu Tyr Lys Ala Pro Ile Leu Leu 
    690                 695                 700                 


Ala Leu Val Ala Gly Glu Ala Ala Gly Ile Met Glu Asn Ile Ser Asp 
705                 710                 715                 720 


Asp Val Ile Val Gly Arg Cys Leu Ala Ile Leu Lys Gly Ile Phe Gly 
                725                 730                 735     


Ser Ser Ala Val Pro Gln Pro Lys Glu Thr Val Val Ser Arg Trp Arg 
            740                 745                 750         


Ala Asp Pro Trp Ala Arg Gly Ser Tyr Ser Tyr Val Ala Ala Gly Ser 
        755                 760                 765             


Ser Gly Asn Asp Tyr Asp Leu Met Ala Gln Pro Ile Thr Pro Gly Pro 
    770                 775                 780                 


Ser Ile Pro Gly Ala Pro Gln Pro Ile Pro Arg Leu Phe Phe Ala Gly 
785                 790                 795                 800 


Glu His Thr Ile Arg Asn Tyr Pro Ala Thr Val His Gly Ala Leu Leu 
                805                 810                 815     


Ser Gly Leu Arg Glu Ala Gly Arg Ile Ala Asp Gln Phe Leu Gly Ala 
            820                 825                 830         


Met Tyr Thr Leu Pro Arg Gln Ala Thr Pro Gly Val Pro Ala Gln Gln 
        835                 840                 845             


Ser Pro Ser Met 
    850         


<210>  2
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Formula XIX embodiment peptide

<400>  2

Arg Arg Thr Ser Arg Arg Lys Arg Ala Lys Val 
1               5                   10      


<210>  3
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Formula XIX embodiment peptide

<400>  3

Arg Arg Thr Ala Arg Arg Lys Arg Ala Lys Val 
1               5                   10      


<210>  4
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Formula XIX embodiment peptide

<400>  4

Arg Trp Arg Arg Thr Ala Arg Arg Lys Arg Ala Lys Val 
1               5                   10              


<210>  5
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Formula XIX embodiment peptide

<400>  5

Glu Gly Arg Arg Thr Ser Arg Arg Lys Arg Ala Lys Val Glu 
1               5                   10                  


<210>  6
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  6

Tyr Gly Arg Lys Lys Arg Pro Gln Arg Arg Arg 
1               5                   10      


<210>  7
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide


<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  X = W or R

<400>  7

Arg Arg Trp Arg Arg Trp Trp Arg Arg Trp Trp Arg Arg Trp Arg Arg 
1               5                   10                  15      


Xaa 
    


<210>  8
<211>  40
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  8

Cys Trp Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Lys Lys Lys Lys Cys Trp Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
            20                  25                  30          


Lys Lys Lys Lys Lys Lys Lys Lys 
        35                  40  


<210>  9
<211>  60
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  9

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Lys Lys Trp Cys Cys Trp Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
            20                  25                  30          


Lys Lys Lys Lys Lys Lys Lys Lys Cys Trp Lys Lys Lys Lys Lys Lys 
        35                  40                  45              


Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
    50                  55                  60  


<210>  10
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  10

Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys 
1               5                   10                  15      


Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25      


<210>  11
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  11

Gly Leu Phe Glu Ala Leu Glu Glu Leu Trp Glu Ala Lys 
1               5                   10              


<210>  12
<211>  65
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  12

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Gly Gly Cys Arg Gly Asp Met Phe Gly Cys Ala Lys Lys Lys Lys Lys 
            20                  25                  30          


Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Arg Gly Asp Lys Lys 
        35                  40                  45              


Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Arg Gly 
    50                  55                  60                  


Asp 
65  


<210>  13
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  13

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Gly Gly Cys Met Phe Gly Cys Gly Gly 
            20                  25  


<210>  14
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  14

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Ile Cys Arg Arg Ala Arg Gly Asp Asn Pro Asp Asp Arg Cys Thr 
            20                  25                  30      


<210>  15
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  15

Lys Lys Trp Lys Met Arg Arg Asn Gln Phe Trp Val Lys Val Gln Arg 
1               5                   10                  15      


Asx Ala Lys 
            


<210>  16
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  16

Val Ala Tyr Ile Ser Arg Gly Gly Val Ser Thr Tyr Tyr Ser Asp Thr 
1               5                   10                  15      


Val Lys Gly Arg Phe Thr Arg Gln Lys Tyr Asn Lys Arg Ala 
            20                  25                  30  


<210>  17
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  17

Ile Gly Arg Ile Asp Pro Ala Asn Gly Lys Thr Lys Tyr Ala Pro Lys 
1               5                   10                  15      


Phe Gln Asp Lys Ala Thr Arg Ser Asn Tyr Tyr Gly Asn Ser Pro Ser 
            20                  25                  30          


<210>  18
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  18

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  19
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  19

Pro Leu Ala Glu Ile Asp Gly Ile Glu Leu Thr Tyr 
1               5                   10          


<210>  20
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  20

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Gly Gly Pro Leu Ala Glu Ile Asp Gly Ile Glu Leu Gly Ala 
            20                  25                  30  


<210>  21
<211>  30
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  21

Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys Lys 
1               5                   10                  15      


Gly Gly Pro Leu Ala Glu Ile Asp Gly Ile Glu Leu Cys Ala 
            20                  25                  30  


<210>  22
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  22

Gly Ala Leu Phe Leu Gly Phe Leu Gly Gly Ala Ala Gly Ser Thr Met 
1               5                   10                  15      


Gly Ala Trp Ser Gln Pro Lys Ser Lys Arg Lys Val 
            20                  25              


<210>  23
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  23

Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His 
1               5                   10                  15      


Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys 
            20                  25              


<210>  24
<211>  48
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  24

Leu Ala Arg Leu Leu Ala Arg Leu Leu Ala Arg Leu Leu Ala Arg Leu 
1               5                   10                  15      


Leu Ala Arg Leu Leu Ala Arg Leu Leu Ala Arg Leu Leu Ala Arg Leu 
            20                  25                  30          


Leu Ala Arg Leu Leu Ala Arg Leu Leu Ala Arg Leu Leu Ala Arg Leu 
        35                  40                  45              


<210>  25
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  25

Lys Leu Leu Lys Leu Leu Leu Lys Leu Trp Leu Leu Lys Leu Leu Leu 
1               5                   10                  15      


<210>  26
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  26

Lys Lys Lys Lys Lys Lys Lys Lys Gly Gly Cys Lys Lys 
1               5                   10              


<210>  27
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  27

Lys Trp Lys Lys Lys Trp Lys Lys Gly Cys Cys Lys Trp Lys 
1               5                   10                  


<210>  28
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  28

Arg Trp Arg Arg Arg Trp Arg Arg Gly Gly Cys Arg Trp Arg 
1               5                   10                  


<210>  29
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  29

Pro Glu Val Lys Lys Lys Arg Lys Pro Glu Tyr Pro 
1               5                   10          


<210>  30
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  30

Thr Pro Pro Lys Lys Lys Arg Lys Val Glu Asp Pro 
1               5                   10          


<210>  31
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  31

Gly Gly Gly Gly Pro Lys Lys Lys Arg Lys Val Gly Gly 
1               5                   10              


<210>  32
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  32

Gly Gly Gly Phe Ser Thr Ser Leu Arg Ala Arg Lys Ala 
1               5                   10              


<210>  33
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  33

Cys Lys Lys Lys Lys Lys Lys Ser Glu Asp Glu Tyr Pro Tyr Val Pro 
1               5                   10                  15      


Asn 
    


<210>  34
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  34

Cys Lys Lys Lys Lys Lys Lys Lys Ser Glu Asp Glu Tyr Pro Tyr Val 
1               5                   10                  15      


Pro Asn Phe Ser Thr Ser Leu Arg Ala Arg Lys Ala 
            20                  25              


<210>  35
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  35

Leu Val Arg Lys Lys Arg Lys Thr Glu Glu Glu Ser Pro Leu Lys Asp 
1               5                   10                  15      


Lys Asp Ala Lys Lys Ser Lys Gln Glu 
            20                  25  


<210>  36
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  36

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  37
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  37

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  38
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  38

Thr Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
1               5                   10                  15      


Arg Leu Leu Arg Lys 
            20      


<210>  39
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  39

Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg 
1               5                   10              


<210>  40
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  40

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  41
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  41

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210>  42
<211>  28
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  42

Met Ala Asn Leu Gly Tyr Trp Leu Leu Ala Leu Phe Val Thr Met Trp 
1               5                   10                  15      


Thr Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro 
            20                  25              


<210>  43
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  43

Leu Leu Ile Ile Leu Arg Arg Arg Ile Arg Lys Gln Ala His Ala His 
1               5                   10                  15      


Ser Lys 
        


<210>  44
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  44

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  45
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  45

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  46
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  46

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  47
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  47

Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu 
1               5                   10                  15      


Ala Lys Lys Ile Leu 
            20      


<210>  48
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  48

Gly Leu Trp Arg Ala Leu Trp Arg Leu Leu Arg Ser Leu Trp Arg Leu 
1               5                   10                  15      


Leu Trp Arg Ala 
            20  


<210>  49
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  49

Ser Asp Leu Trp Glu Met Met Met Val Ser Leu Ala Cys Gln Tyr 
1               5                   10                  15  


<210>  50
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  50

Thr Ser Pro Leu Asn Ile His Asn Gly Gln Lys Leu 
1               5                   10          


<210>  51
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  51

Asp Pro Lys Gly Asp Pro Lys Gly Val Thr Val Thr Val Thr Val Thr 
1               5                   10                  15      


Val Thr Gly Lys Gly Asp Pro Lys Pro Asp 
            20                  25      


<210>  52
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Cell-penetrating peptide

<400>  52

Arg Val Ile Arg Val Trp Phe Gln Asn Lys Arg Cys Lys Asp Lys Lys 
1               5                   10                  15      


<210>  53
<211>  440
<212>  PRT
<213>  Artificial

<220>
<223>  Nivolumab heavy chain variable region

<400>  53

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
            260                 265                 270         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
305                 310                 315                 320 


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                325                 330                 335     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
            340                 345                 350         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        355                 360                 365             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    370                 375                 380                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
385                 390                 395                 400 


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
                405                 410                 415     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            420                 425                 430         


Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440 


<210>  54
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  Nivolumab light chain variable region

<400>  54

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp Pro Arg 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  55
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  Pembrolizumab heavy chain variable region

<400>  55

Gln Val Gln Leu Val Gln Ser Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Asn Pro Ser Asn Gly Gly Thr Asn Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Arg Val Thr Leu Thr Thr Asp Ser Ser Thr Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Lys Ser Leu Gln Phe Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Arg Phe Asp Met Gly Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro 
    210                 215                 220                 


Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  56
<211>  218
<212>  PRT
<213>  Artificial

<220>
<223>  Pembrolizumab light chain variable region

<400>  56

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Lys Gly Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Leu Ala Ser Tyr Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Asp Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


