                               SEQUENCE LISTING

<110> BROWN UNIVERSITY
 
<120> COMPOSITIONS AND METHODS FOR SUPPRESSING NEUROLOGICAL DISEASE

<130> 405505-5270001WO

<140> PCT/US2018/062580
<141> 2018-11-27

<150> 62/590,902
<151> 2017-11-27

<160> 30    

<170> PatentIn version 3.5

<210> 1
<211> 556
<212> PRT
<213> Drosophila melanogaster

<400> 1
Met Ala Val Glu Val Val Gln Glu Thr Leu Gln Gln Ala Ala Ser Ser 
1               5                   10                  15      


Ser Ser Thr Thr Val Leu Gly Phe Ser Pro Met Leu Thr Thr Leu Val 
            20                  25                  30          


Gly Thr Leu Val Ala Met Ala Leu Tyr Glu Tyr Trp Arg Arg Asn Ser 
        35                  40                  45              


Arg Glu Tyr Arg Met Val Ala Asn Ile Pro Ser Pro Pro Glu Leu Pro 
    50                  55                  60                  


Ile Leu Gly Gln Ala His Val Ala Ala Gly Leu Ser Asn Ala Glu Ile 
65                  70                  75                  80  


Leu Ala Val Gly Leu Gly Tyr Leu Asn Lys Tyr Gly Glu Thr Met Lys 
                85                  90                  95      


Ala Trp Leu Gly Asn Val Leu Leu Val Phe Leu Thr Asn Pro Ser Asp 
            100                 105                 110         


Ile Glu Leu Ile Leu Ser Gly His Gln His Leu Thr Lys Ala Glu Glu 
        115                 120                 125             


Tyr Arg Tyr Phe Lys Pro Trp Phe Gly Asp Gly Leu Leu Ile Asn Asn 
    130                 135                 140                 


Gly His His Trp Arg His His Arg Lys Met Ile Ala Pro Thr Phe His 
145                 150                 155                 160 


Gln Ser Ile Leu Lys Ser Phe Val Pro Thr Phe Val Asp His Ser Lys 
                165                 170                 175     


Ala Val Val Ala Arg Met Gly Leu Glu Ala Gly Lys Ser Phe Asp Val 
            180                 185                 190         


His Asp Tyr Met Ser Gln Thr Thr Val Asp Ile Leu Leu Ser Thr Ala 
        195                 200                 205             


Met Gly Val Lys Lys Leu Pro Glu Gly Asn Lys Ser Phe Glu Tyr Ala 
    210                 215                 220                 


Gln Ala Val Val Asp Met Cys Asp Ile Ile His Lys Arg Gln Val Lys 
225                 230                 235                 240 


Leu Leu Tyr Arg Leu Asp Ser Ile Tyr Lys Phe Thr Lys Leu Arg Glu 
                245                 250                 255     


Lys Gly Asp Arg Met Met Asn Ile Ile Leu Gly Met Thr Ser Lys Val 
            260                 265                 270         


Val Lys Asp Arg Lys Glu Asn Phe Gln Glu Glu Ser Arg Ala Ile Val 
        275                 280                 285             


Glu Glu Ile Ser Thr Pro Val Ala Ser Thr Pro Ala Ser Lys Lys Glu 
    290                 295                 300                 


Gly Leu Arg Asp Asp Leu Asp Asp Ile Asp Glu Asn Asp Val Gly Ala 
305                 310                 315                 320 


Lys Arg Arg Leu Ala Leu Leu Asp Ala Met Val Glu Met Ala Lys Asn 
                325                 330                 335     


Pro Asp Ile Glu Trp Asn Glu Lys Asp Ile Met Asp Glu Val Asn Thr 
            340                 345                 350         


Ile Met Phe Glu Gly His Asp Thr Thr Ser Ala Gly Ser Ser Phe Ala 
        355                 360                 365             


Leu Cys Met Met Gly Ile His Lys Asp Ile Gln Ala Lys Val Phe Ala 
    370                 375                 380                 


Glu Gln Lys Ala Ile Phe Gly Asp Asn Met Leu Arg Asp Cys Thr Phe 
385                 390                 395                 400 


Ala Asp Thr Met Glu Met Lys Tyr Leu Glu Arg Val Ile Leu Glu Thr 
                405                 410                 415     


Leu Arg Leu Tyr Pro Pro Val Pro Leu Ile Ala Arg Arg Leu Asp Tyr 
            420                 425                 430         


Asp Leu Lys Leu Ala Ser Gly Pro Tyr Thr Val Pro Lys Gly Thr Thr 
        435                 440                 445             


Val Ile Val Leu Gln Tyr Cys Val His Arg Arg Pro Asp Ile Tyr Pro 
    450                 455                 460                 


Asn Pro Thr Lys Phe Asp Pro Asp Asn Phe Leu Pro Glu Arg Met Ala 
465                 470                 475                 480 


Asn Arg His Tyr Tyr Ser Phe Ile Pro Phe Ser Ala Gly Pro Arg Ser 
                485                 490                 495     


Cys Val Gly Arg Lys Tyr Ala Met Leu Lys Leu Lys Val Leu Leu Ser 
            500                 505                 510         


Thr Ile Val Arg Asn Tyr Ile Val His Ser Thr Asp Thr Glu Ala Asp 
        515                 520                 525             


Phe Lys Leu Gln Ala Asp Ile Ile Leu Lys Leu Glu Asn Gly Phe Asn 
    530                 535                 540                 


Val Ser Leu Glu Lys Arg Gln Tyr Ala Thr Val Ala 
545                 550                 555     


<210> 2
<211> 556
<212> PRT
<213> Drosophila melanogaster

<400> 2
Met Ala Val Glu Val Val Gln Glu Thr Leu Gln Gln Ala Ala Ser Ser 
1               5                   10                  15      


Ser Ser Thr Thr Val Leu Gly Phe Ser Pro Met Leu Thr Thr Leu Val 
            20                  25                  30          


Gly Thr Leu Val Ala Met Ala Leu Tyr Glu Tyr Trp Arg Arg Asn Ser 
        35                  40                  45              


Arg Glu Tyr Arg Met Val Ala Asn Ile Pro Ser Pro Pro Glu Leu Pro 
    50                  55                  60                  


Ile Leu Gly Gln Ala His Val Ala Ala Gly Leu Ser Asn Ala Glu Ile 
65                  70                  75                  80  


Leu Ala Val Gly Leu Gly Tyr Leu Asn Lys Tyr Gly Glu Thr Met Lys 
                85                  90                  95      


Ala Trp Leu Gly Asn Val Leu Leu Val Phe Leu Thr Asn Pro Ser Asn 
            100                 105                 110         


Ile Glu Leu Ile Leu Ser Gly His Gln His Leu Thr Lys Ala Glu Glu 
        115                 120                 125             


Tyr Arg Tyr Phe Lys Pro Trp Phe Gly Asp Gly Leu Leu Ile Ser Asn 
    130                 135                 140                 


Gly His His Trp Arg His His Arg Lys Met Ile Ala Pro Thr Phe His 
145                 150                 155                 160 


Gln Ser Ile Leu Lys Ser Phe Val Pro Thr Phe Val Asp His Ser Lys 
                165                 170                 175     


Ala Val Val Ala Arg Met Gly Leu Glu Ala Gly Lys Ser Phe Asp Val 
            180                 185                 190         


His Asp Tyr Met Ser Gln Thr Thr Val Asp Ile Leu Leu Ser Thr Ala 
        195                 200                 205             


Met Gly Val Lys Lys Leu Pro Glu Gly Asn Lys Ser Phe Glu Tyr Ala 
    210                 215                 220                 


Gln Ala Val Val Asp Met Cys Asp Ile Ile His Lys Arg Gln Val Lys 
225                 230                 235                 240 


Leu Leu Tyr Arg Leu Asp Ser Ile Tyr Lys Phe Thr Lys Leu Arg Glu 
                245                 250                 255     


Lys Gly Asp Arg Met Met Asn Ile Ile Leu Gly Met Thr Ser Lys Val 
            260                 265                 270         


Val Lys Asp Arg Lys Glu Asn Phe Gln Glu Glu Ser Arg Ala Ile Val 
        275                 280                 285             


Glu Glu Ile Ser Thr Pro Val Ala Ser Thr Pro Ala Ser Lys Lys Glu 
    290                 295                 300                 


Gly Leu Arg Asp Asp Leu Asp Asp Ile Asp Glu Asn Asp Val Gly Ala 
305                 310                 315                 320 


Lys Arg Arg Leu Ala Leu Leu Asp Ala Met Val Glu Met Ala Lys Asn 
                325                 330                 335     


Pro Asp Ile Glu Trp Asn Glu Lys Asp Ile Met Asp Glu Val Asn Thr 
            340                 345                 350         


Ile Met Phe Glu Gly His Asp Thr Thr Ser Ala Gly Ser Ser Phe Ala 
        355                 360                 365             


Leu Cys Met Met Gly Ile His Lys Asp Ile Gln Ala Lys Val Phe Ala 
    370                 375                 380                 


Glu Gln Lys Ala Ile Phe Gly Asp Asn Met Leu Arg Asp Cys Thr Phe 
385                 390                 395                 400 


Ala Asp Thr Met Glu Met Lys Tyr Leu Glu Arg Val Ile Leu Glu Thr 
                405                 410                 415     


Leu Arg Leu Tyr Pro Pro Val Pro Leu Ile Ala Arg Arg Leu Asp Tyr 
            420                 425                 430         


Asp Leu Lys Leu Ala Ser Gly Pro Tyr Thr Val Pro Lys Gly Thr Thr 
        435                 440                 445             


Val Ile Val Leu Gln Tyr Cys Val His Arg Arg Pro Asp Ile Tyr Pro 
    450                 455                 460                 


Asn Pro Thr Lys Phe Asp Pro Asp Asn Phe Leu Pro Glu Arg Met Ala 
465                 470                 475                 480 


Asn Arg His Tyr Tyr Ser Phe Ile Pro Phe Ser Ala Gly Pro Arg Ser 
                485                 490                 495     


Cys Val Gly Arg Lys Tyr Ala Met Leu Lys Leu Lys Val Leu Leu Ser 
            500                 505                 510         


Thr Ile Val Arg Asn Tyr Ile Val His Ser Thr Asp Thr Glu Ala Asp 
        515                 520                 525             


Phe Lys Leu Gln Ala Asp Ile Ile Leu Lys Leu Glu Asn Gly Phe Asn 
    530                 535                 540                 


Val Ser Leu Glu Lys Arg Gln Tyr Ala Thr Val Ala 
545                 550                 555     


<210> 3
<211> 556
<212> PRT
<213> Drosophila melanogaster

<400> 3
Met Ala Val Glu Val Val Gln Glu Thr Leu Gln Gln Ala Ala Ser Ser 
1               5                   10                  15      


Ser Ser Thr Thr Val Leu Gly Phe Ser Pro Met Leu Thr Thr Leu Val 
            20                  25                  30          


Gly Thr Leu Val Ala Met Ala Leu Tyr Glu Tyr Trp Arg Arg Asn Ser 
        35                  40                  45              


Arg Glu Tyr Arg Met Val Ala Asn Ile Pro Ser Pro Pro Glu Leu Pro 
    50                  55                  60                  


Ile Leu Gly Gln Ala His Val Ala Ala Gly Leu Ser Asn Ala Glu Ile 
65                  70                  75                  80  


Leu Ala Val Gly Leu Gly Tyr Leu Asn Lys Tyr Glu Glu Thr Met Lys 
                85                  90                  95      


Ala Trp Leu Gly Asn Val Leu Leu Val Phe Leu Thr Asn Pro Ser Asp 
            100                 105                 110         


Ile Glu Leu Ile Leu Ser Gly His Gln His Leu Thr Lys Ala Glu Glu 
        115                 120                 125             


Tyr Arg Tyr Phe Lys Pro Trp Phe Gly Asp Gly Leu Leu Ile Ser Asn 
    130                 135                 140                 


Gly His His Trp Arg His His Arg Lys Met Ile Ala Pro Thr Phe His 
145                 150                 155                 160 


Gln Ser Ile Leu Lys Ser Phe Val Pro Thr Phe Val Asp His Ser Lys 
                165                 170                 175     


Ala Val Val Ala Arg Met Gly Leu Glu Ala Gly Lys Ser Phe Asp Val 
            180                 185                 190         


His Asp Tyr Met Ser Gln Thr Thr Val Asp Ile Leu Leu Ser Thr Ala 
        195                 200                 205             


Met Gly Val Lys Lys Leu Pro Glu Gly Asn Lys Ser Phe Glu Tyr Ala 
    210                 215                 220                 


Gln Ala Val Val Asp Met Cys Asp Ile Ile His Lys Arg Gln Val Lys 
225                 230                 235                 240 


Leu Leu Tyr Arg Leu Asp Ser Ile Tyr Lys Phe Thr Lys Leu Arg Glu 
                245                 250                 255     


Lys Gly Asp Arg Met Met Asn Ile Ile Leu Gly Met Thr Ser Lys Val 
            260                 265                 270         


Val Lys Asp Arg Lys Glu Asn Phe Gln Glu Glu Ser Arg Ala Ile Val 
        275                 280                 285             


Glu Glu Ile Ser Thr Pro Val Ala Ser Thr Pro Ala Ser Lys Lys Glu 
    290                 295                 300                 


Gly Leu Arg Asp Asp Leu Asp Asp Ile Asp Glu Asn Asp Val Gly Ala 
305                 310                 315                 320 


Lys Arg Arg Leu Ala Leu Leu Asp Ala Met Val Glu Met Ala Lys Asn 
                325                 330                 335     


Pro Asp Ile Glu Trp Asn Glu Lys Asp Ile Met Asp Glu Val Asn Thr 
            340                 345                 350         


Ile Met Phe Glu Gly His Asp Thr Thr Ser Ala Gly Ser Ser Phe Ala 
        355                 360                 365             


Leu Cys Met Met Gly Ile His Lys Asp Ile Gln Ala Lys Val Phe Ala 
    370                 375                 380                 


Glu Gln Lys Ala Ile Phe Gly Asp Asn Met Leu Arg Asp Cys Thr Phe 
385                 390                 395                 400 


Ala Asp Thr Met Glu Met Lys Tyr Leu Glu Arg Val Ile Leu Glu Thr 
                405                 410                 415     


Leu Arg Leu Tyr Pro Pro Val Pro Leu Ile Ala Arg Arg Leu Asp Tyr 
            420                 425                 430         


Asp Leu Lys Leu Ala Ser Gly Pro Tyr Thr Val Pro Lys Gly Thr Thr 
        435                 440                 445             


Val Ile Val Leu Gln Tyr Cys Val His Arg Arg Pro Asp Ile Tyr Pro 
    450                 455                 460                 


Asn Pro Thr Lys Phe Asp Pro Asp Asn Phe Leu Pro Glu Arg Met Ala 
465                 470                 475                 480 


Asn Arg His Tyr Tyr Ser Phe Ile Pro Phe Ser Ala Gly Pro Arg Ser 
                485                 490                 495     


Cys Val Gly Arg Lys Tyr Ala Met Leu Lys Leu Lys Val Leu Leu Ser 
            500                 505                 510         


Thr Ile Val Arg Asn Tyr Ile Val His Ser Thr Asp Thr Glu Ala Asp 
        515                 520                 525             


Phe Lys Leu Gln Ala Asp Ile Ile Leu Lys Leu Glu Asn Gly Phe Asn 
    530                 535                 540                 


Val Ser Leu Glu Lys Arg Gln Tyr Ala Thr Val Ala 
545                 550                 555     


<210> 4
<211> 556
<212> PRT
<213> Drosophila melanogaster

<400> 4
Met Ala Val Glu Val Val Gln Glu Thr Leu Gln Gln Ala Ala Ser Ser 
1               5                   10                  15      


Ser Ser Thr Thr Val Leu Gly Phe Ser Pro Met Leu Thr Thr Leu Val 
            20                  25                  30          


Gly Thr Leu Val Ala Met Ala Leu Tyr Glu Tyr Trp Arg Arg Asn Ser 
        35                  40                  45              


Arg Glu Tyr Arg Met Val Ala Asn Ile Pro Ser Pro Pro Glu Leu Pro 
    50                  55                  60                  


Ile Leu Gly Gln Ala His Val Ala Ala Gly Leu Ser Asn Ala Glu Ile 
65                  70                  75                  80  


Leu Ala Val Gly Leu Gly Tyr Leu Asn Lys Tyr Gly Glu Thr Met Lys 
                85                  90                  95      


Ala Trp Leu Gly Asn Val Leu Leu Val Phe Leu Thr Asn Pro Ser Asp 
            100                 105                 110         


Ile Glu Leu Ile Leu Ser Gly His Gln His Leu Thr Lys Ala Glu Glu 
        115                 120                 125             


Tyr Arg Tyr Phe Lys Pro Trp Phe Gly Asp Gly Leu Leu Ile Ser Asn 
    130                 135                 140                 


Gly His His Trp Arg His His Arg Lys Met Ile Ala Pro Thr Phe His 
145                 150                 155                 160 


Gln Ser Ile Leu Lys Ser Phe Val Pro Thr Phe Val Asp His Ser Lys 
                165                 170                 175     


Ala Val Val Ala Arg Met Gly Leu Glu Ala Gly Lys Ser Phe Asp Val 
            180                 185                 190         


His Asp Tyr Met Ser Gln Thr Thr Val Asp Ile Leu Leu Ser Thr Ala 
        195                 200                 205             


Met Gly Val Lys Lys Leu Pro Glu Gly Asn Lys Ser Phe Glu Tyr Ala 
    210                 215                 220                 


Gln Ala Val Val Asp Met Cys Asp Ile Ile His Lys Arg Gln Val Lys 
225                 230                 235                 240 


Leu Leu Tyr Arg Leu Asp Ser Ile Tyr Lys Phe Thr Lys Leu Arg Glu 
                245                 250                 255     


Lys Gly Asp Arg Met Met Asn Ile Ile Leu Gly Met Thr Ser Lys Val 
            260                 265                 270         


Val Lys Asp Arg Lys Glu Asn Phe Gln Glu Glu Ser Arg Ala Ile Val 
        275                 280                 285             


Glu Glu Ile Ser Thr Pro Val Ala Ser Thr Pro Ala Ser Lys Lys Glu 
    290                 295                 300                 


Gly Leu Arg Asp Asp Leu Asp Asp Ile Asp Glu Asn Asp Val Gly Ala 
305                 310                 315                 320 


Lys Arg Arg Leu Ala Leu Leu Asp Ala Met Val Glu Ile Ala Lys Asn 
                325                 330                 335     


Pro Asp Ile Glu Trp Asn Glu Lys Asp Ile Met Asp Glu Val Asn Thr 
            340                 345                 350         


Ile Met Phe Glu Gly His Asp Thr Thr Ser Ala Gly Ser Ser Phe Ala 
        355                 360                 365             


Leu Cys Met Met Gly Ile His Lys Asp Ile Gln Ala Lys Val Phe Ala 
    370                 375                 380                 


Glu Gln Lys Ala Ile Phe Gly Asp Asn Met Leu Arg Asp Cys Thr Phe 
385                 390                 395                 400 


Ala Asp Thr Met Glu Met Lys Tyr Leu Glu Arg Val Ile Leu Glu Thr 
                405                 410                 415     


Leu Arg Leu Tyr Pro Pro Val Pro Leu Ile Ala Arg Arg Leu Asp Tyr 
            420                 425                 430         


Asp Leu Lys Leu Ala Ser Gly Pro Tyr Thr Val Pro Lys Gly Thr Thr 
        435                 440                 445             


Val Ile Val Leu Gln Tyr Cys Val His Arg Arg Pro Asp Ile Tyr Pro 
    450                 455                 460                 


Asn Pro Thr Lys Phe Asp Pro Asp Asn Phe Leu Pro Glu Arg Met Ala 
465                 470                 475                 480 


Asn Arg His Tyr Tyr Ser Phe Ile Pro Phe Ser Ala Gly Pro Arg Ser 
                485                 490                 495     


Cys Val Gly Arg Lys Tyr Ala Met Leu Lys Leu Lys Val Leu Leu Ser 
            500                 505                 510         


Thr Ile Val Arg Asn Tyr Ile Val His Ser Thr Asp Thr Glu Ala Asp 
        515                 520                 525             


Phe Lys Leu Gln Ala Asp Ile Ile Leu Lys Leu Glu Asn Gly Phe Asn 
    530                 535                 540                 


Val Ser Leu Glu Lys Arg Gln Tyr Ala Thr Val Ala 
545                 550                 555     


<210> 5
<211> 525
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Gly Leu Trp Leu Gly Leu Val Trp Gln Lys Leu Leu Leu Trp 
1               5                   10                  15      


Gly Ala Ala Ser Ala Leu Ser Leu Ala Gly Ala Ser Leu Val Leu Ser 
            20                  25                  30          


Leu Leu Gln Arg Val Ala Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg 
        35                  40                  45              


Pro Ile Pro Thr Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Leu Met Lys Pro Asp Gly Arg Glu Phe Phe Gln Gln Ile Ile Glu Tyr 
65                  70                  75                  80  


Thr Glu Glu Tyr Arg His Met Pro Leu Leu Lys Leu Trp Val Gly Pro 
                85                  90                  95      


Val Pro Met Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Val Ile Leu 
            100                 105                 110         


Thr Ser Ser Lys Gln Ile Asp Lys Ser Ser Met Tyr Lys Phe Leu Glu 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Asn Thr Gly Asn Lys Trp Arg 
    130                 135                 140                 


Ser Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asp Phe Leu Asp Ile Met Asn Glu Gln Ala Asn Ile Leu Val Lys Lys 
                165                 170                 175     


Leu Glu Lys His Ile Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile 
            180                 185                 190         


Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Ser Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr 
    210                 215                 220                 


Arg Met Ser Glu Met Ile Phe Arg Arg Ile Lys Met Pro Trp Leu Trp 
225                 230                 235                 240 


Leu Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Lys 
                245                 250                 255     


Ser Leu Gln Ile Leu His Thr Phe Thr Asn Ser Val Ile Ala Glu Arg 
            260                 265                 270         


Ala Asn Glu Met Asn Ala Asn Glu Asp Cys Arg Gly Asp Gly Arg Gly 
        275                 280                 285             


Ser Ala Pro Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu 
    290                 295                 300                 


Ser Val Thr Asp Asp Glu Gly Asn Arg Leu Ser His Glu Asp Ile Arg 
305                 310                 315                 320 


Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala 
                325                 330                 335     


Ala Ile Asn Trp Ser Leu Tyr Leu Leu Gly Ser Asn Pro Glu Val Gln 
            340                 345                 350         


Lys Lys Val Asp His Glu Leu Asp Asp Val Phe Gly Lys Ser Asp Arg 
        355                 360                 365             


Pro Ala Thr Val Glu Asp Leu Lys Lys Leu Arg Tyr Leu Glu Cys Val 
    370                 375                 380                 


Ile Lys Glu Thr Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg 
385                 390                 395                 400 


Ser Val Ser Glu Asp Cys Glu Val Ala Gly Tyr Arg Val Leu Lys Gly 
                405                 410                 415     


Thr Glu Ala Val Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr 
            420                 425                 430         


Phe Pro Asn Pro Glu Glu Phe Gln Pro Glu Arg Phe Phe Pro Glu Asn 
        435                 440                 445             


Ala Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro 
    450                 455                 460                 


Arg Asn Cys Ile Gly Gln Lys Phe Ala Val Met Glu Glu Lys Thr Ile 
465                 470                 475                 480 


Leu Ser Cys Ile Leu Arg His Phe Trp Ile Glu Ser Asn Gln Lys Arg 
                485                 490                 495     


Glu Glu Leu Gly Leu Glu Gly Gln Leu Ile Leu Arg Pro Ser Asn Gly 
            500                 505                 510         


Ile Trp Ile Lys Leu Lys Arg Arg Asn Ala Asp Glu Arg 
        515                 520                 525 


<210> 6
<211> 556
<212> PRT
<213> Drosophila melanogaster

<400> 6
Met Ala Val Glu Val Val Gln Glu Thr Leu Gln Gln Ala Ala Ser Ser 
1               5                   10                  15      


Ser Ser Thr Thr Val Leu Gly Phe Ser Pro Met Leu Thr Thr Leu Val 
            20                  25                  30          


Gly Thr Leu Val Ala Met Ala Leu Tyr Glu Tyr Trp Arg Arg Asn Ser 
        35                  40                  45              


Arg Glu Tyr Arg Met Val Ala Asn Ile Pro Ser Pro Pro Glu Leu Pro 
    50                  55                  60                  


Ile Leu Gly Gln Ala His Val Ala Ala Gly Leu Ser Asn Ala Glu Ile 
65                  70                  75                  80  


Leu Ala Val Gly Leu Gly Tyr Leu Asn Lys Tyr Gly Glu Thr Met Lys 
                85                  90                  95      


Ala Trp Leu Gly Asn Val Leu Leu Val Phe Leu Thr Asn Pro Ser Asp 
            100                 105                 110         


Ile Glu Leu Ile Leu Ser Gly His Gln His Leu Thr Lys Ala Glu Glu 
        115                 120                 125             


Tyr Arg Tyr Phe Lys Pro Trp Phe Gly Asp Gly Leu Leu Ile Ser Asn 
    130                 135                 140                 


Gly His His Trp Arg His His Arg Lys Met Ile Ala Pro Thr Phe His 
145                 150                 155                 160 


Gln Ser Ile Leu Lys Ser Phe Val Pro Thr Phe Val Asp His Ser Lys 
                165                 170                 175     


Ala Val Val Ala Arg Met Gly Leu Glu Ala Gly Lys Ser Phe Asp Val 
            180                 185                 190         


His Asp Tyr Met Ser Gln Thr Thr Val Asp Ile Leu Leu Ser Thr Ala 
        195                 200                 205             


Met Gly Val Lys Lys Leu Pro Glu Gly Asn Lys Ser Phe Glu Tyr Ala 
    210                 215                 220                 


Gln Ala Val Val Asp Met Cys Asp Ile Ile His Lys Arg Gln Val Lys 
225                 230                 235                 240 


Leu Leu Tyr Arg Leu Asp Ser Ile Tyr Lys Phe Thr Lys Leu Arg Glu 
                245                 250                 255     


Lys Gly Asp Arg Met Met Asn Ile Ile Leu Gly Met Thr Ser Lys Val 
            260                 265                 270         


Val Lys Asp Arg Lys Glu Asn Phe Gln Glu Glu Ser Arg Ala Ile Val 
        275                 280                 285             


Glu Glu Ile Ser Thr Pro Val Ala Ser Thr Pro Ala Ser Lys Lys Glu 
    290                 295                 300                 


Gly Leu Arg Asp Asp Leu Asp Asp Ile Asp Glu Asn Asp Val Gly Ala 
305                 310                 315                 320 


Lys Arg Arg Leu Ala Leu Leu Asp Ala Met Val Glu Met Ala Lys Asn 
                325                 330                 335     


Pro Asp Ile Glu Trp Asn Glu Lys Asp Ile Met Asp Glu Val Asn Thr 
            340                 345                 350         


Ile Met Phe Glu Gly His Asp Thr Thr Ser Ala Gly Ser Ser Phe Ala 
        355                 360                 365             


Leu Cys Met Met Gly Ile His Lys Asp Ile Gln Ala Lys Val Phe Ala 
    370                 375                 380                 


Glu Gln Lys Ala Ile Phe Gly Asp Asn Met Leu Arg Asp Cys Thr Phe 
385                 390                 395                 400 


Ala Asp Thr Met Glu Met Lys Tyr Leu Glu Arg Val Ile Leu Glu Thr 
                405                 410                 415     


Leu Arg Leu Tyr Pro Pro Val Pro Leu Ile Ala Arg Arg Leu Asp Tyr 
            420                 425                 430         


Asp Leu Lys Leu Ala Ser Gly Pro Tyr Thr Val Pro Lys Gly Thr Thr 
        435                 440                 445             


Val Ile Val Leu Gln Tyr Cys Val His Arg Arg Pro Asp Ile Tyr Pro 
    450                 455                 460                 


Asn Pro Thr Lys Phe Asp Pro Asp Asn Phe Leu Pro Glu Arg Met Ala 
465                 470                 475                 480 


Asn Arg His Tyr Tyr Ser Phe Ile Pro Phe Ser Ala Gly Pro Arg Ser 
                485                 490                 495     


Cys Val Gly Arg Lys Tyr Ala Met Leu Lys Leu Lys Val Leu Leu Ser 
            500                 505                 510         


Thr Ile Val Arg Asn Tyr Ile Val His Ser Thr Asp Thr Glu Ala Asp 
        515                 520                 525             


Phe Lys Leu Gln Ala Asp Ile Ile Leu Lys Leu Glu Asn Gly Phe Asn 
    530                 535                 540                 


Val Ser Leu Glu Lys Arg Gln Tyr Ala Thr Val Ala 
545                 550                 555     


<210> 7
<211> 525
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Gly Leu Trp Leu Gly Leu Val Trp Gln Lys Leu Leu Leu Trp 
1               5                   10                  15      


Gly Ala Ala Ser Ala Leu Ser Leu Ala Gly Ala Ser Leu Val Leu Ser 
            20                  25                  30          


Leu Leu Gln Arg Val Ala Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg 
        35                  40                  45              


Pro Ile Pro Thr Val Ala Arg Ala Tyr Pro Leu Val Gly His Ala Leu 
    50                  55                  60                  


Leu Met Lys Pro Asp Gly Arg Glu Phe Phe Gln Gln Ile Ile Glu Tyr 
65                  70                  75                  80  


Thr Glu Glu Tyr Arg His Met Pro Leu Leu Lys Leu Trp Val Gly Pro 
                85                  90                  95      


Val Pro Met Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Val Ile Leu 
            100                 105                 110         


Thr Ser Ser Lys Gln Ile Asp Lys Ser Ser Met Tyr Lys Phe Leu Glu 
        115                 120                 125             


Pro Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Asn Lys Trp Arg 
    130                 135                 140                 


Ser Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu 
145                 150                 155                 160 


Asp Phe Leu Asp Ile Met Asn Glu Gln Ala Asn Ile Leu Val Lys Lys 
                165                 170                 175     


Leu Glu Lys His Ile Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile 
            180                 185                 190         


Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn 
        195                 200                 205             


Ile Gly Ala Gln Ser Asn Asp Asp Ser Glu Tyr Val Arg Ala Val Tyr 
    210                 215                 220                 


Arg Met Ser Glu Met Ile Phe Arg Arg Ile Lys Met Pro Trp Leu Trp 
225                 230                 235                 240 


Leu Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Lys 
                245                 250                 255     


Ser Leu Gln Ile Leu His Thr Phe Thr Asn Ser Val Ile Ala Glu Arg 
            260                 265                 270         


Ala Asn Glu Met Asn Ala Asn Glu Asp Cys Arg Gly Asp Gly Arg Gly 
        275                 280                 285             


Ser Ala Pro Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu 
    290                 295                 300                 


Ser Val Thr Asp Asp Glu Gly Asn Arg Leu Ser His Glu Asp Ile Arg 
305                 310                 315                 320 


Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala 
                325                 330                 335     


Ala Ile Asn Trp Ser Leu Tyr Leu Leu Gly Ser Asn Pro Glu Val Gln 
            340                 345                 350         


Lys Lys Val Asp His Glu Leu Asp Asp Val Phe Gly Lys Ser Asp Arg 
        355                 360                 365             


Pro Ala Thr Val Glu Asp Leu Lys Lys Leu Arg Tyr Leu Glu Cys Val 
    370                 375                 380                 


Ile Lys Glu Thr Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg 
385                 390                 395                 400 


Ser Val Ser Glu Asp Cys Glu Val Ala Gly Tyr Arg Val Leu Lys Gly 
                405                 410                 415     


Thr Glu Ala Val Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr 
            420                 425                 430         


Phe Pro Asn Pro Glu Glu Phe Gln Pro Glu Arg Phe Phe Pro Glu Asn 
        435                 440                 445             


Ala Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro 
    450                 455                 460                 


Arg Asn Cys Ile Gly Gln Lys Phe Ala Val Met Glu Glu Lys Thr Ile 
465                 470                 475                 480 


Leu Ser Cys Ile Leu Arg His Phe Trp Ile Glu Ser Asn Gln Lys Arg 
                485                 490                 495     


Glu Glu Leu Gly Leu Glu Gly Gln Leu Ile Leu Arg Pro Ser Asn Gly 
            500                 505                 510         


Ile Trp Ile Lys Leu Lys Arg Arg Asn Ala Asp Glu Arg 
        515                 520                 525 


<210> 8
<211> 2279
<212> DNA
<213> Drosophila melanogaster

<400> 8
tcacagttga gcactggcgg ctgatatagc aacagtgcca tcttcagaag acaaaaagga       60

tttgcaccag aggaccaggg atcaggagca aagaagcaac agcaaccatg gcagtggaag      120

tagttcagga gacgctgcaa caagcggcgt ccagttcgtc gacgacggtc ctgggattca      180

gtcctatgtt aaccacctta gtgggcaccc tggtggccat ggcattgtac gagtattggc      240

gcaggaatag ccgggaatac cgcatggttg ccaatatacc atccccaccg gagttgccta      300

ttttgggaca ggctcatgtg gccgccggct tgagcaatgc cgagatcctg gccgttggct      360

tgggttacct caacaagtac ggagaaacca tgaaggcctg gttgggcaac gtcctgttgg      420

tgtttctaac caatcccagt gacatcgagt tgatcctgag tgggcaccag cacttgacca      480

aggcggagga gtatcgctac ttcaagccct ggttcggtga tggtctactg atcagcaatg      540

gacatcattg gcgtcatcat cgtaagatga ttgcccccac cttccaccag agcatcttga      600

agagcttcgt gcctacattt gtggatcact caaaggcggt agttgccagg atgggcttag      660

aagcgggcaa atcctttgat gttcatgact atatgtcgca gaccacggtt gacatcctgt      720

tgtctaccgc catgggtgtg aagaagcttc cggagggtaa caagagtttc gaatacgccc      780

aagccgtcgt cgacatgtgt gatatcatac ataagaggca ggttaaatta ctgtaccgcc      840

tggattccat ctacaagttt actaagcttc gcgagaaggg cgatcgcatg atgaacatca      900

tcttgggtat gaccagcaag gtggtcaagg atcgtaagga gaacttccaa gaggagtcac      960

gtgcgattgt tgaggagatt tctacacctg ttgccagcac tcccgcttcc aagaaggagg     1020

gtcttcgcga tgatctggat gatatcgatg aaaatgatgt gggcgccaag aggcgattgg     1080

ctcttctaga tgccatggtg gaaatggcta agaaccccga tatcgagtgg aacgagaagg     1140

acatcatgga tgaggtgaat acaattatgt ttgagggcca cgataccacc tcggcgggat     1200

ctagtttcgc cctctgcatg atgggaatcc acaaggacat ccaggctaaa gtcttcgccg     1260

aacagaaggc catcttcggg gataatatgc tgagggattg cacctttgcc gataccatgg     1320

agatgaaata tttggagcgc gtaattttag agactttgag gttgtaccca ccagtaccac     1380

ttatcgccag gcgtctggac tacgacctga agttggccag tggtccgtac acggttccca     1440

agggcactac ggtcatcgtg ctgcagtact gcgtgcacag acgtccagac atctacccca     1500

atcccaccaa attcgatccg gacaacttcc tacccgagag gatggccaac aggcattact     1560

actccttcat tccctttagc gctggaccca gaagctgtgt gggccgcaag tacgccatgc     1620

tgaagctaaa ggtcctgcta tccaccatcg tgaggaacta tattgtccac tccaccgaca     1680

cggaggcaga tttcaagctg caggctgaca tcatcctaaa gcttgagaat ggattcaatg     1740

tctcgttgga gaagcgtcag tacgccacgg tggcctagaa tccagaaatc taggaccccg     1800

actacacaca cgcaaccccg aacccgaaac cggaatccag ccctgtatat agatgatgaa     1860

taccgatgaa tatcccaaac cgaaaacttg atgacgaact tataaatcta aaacaccgaa     1920

taagaaccca acgcacaagc cagccagaga gtcaattaat ttttctttcg ttttttaact     1980

cgttactttt atatttgatt aatacctttt tgtttgttgg tctttagcga gtggtgcccc     2040

tatataatgt atacgtatat actatatatc cttttaacca actattcaac gcaactgttt     2100

gtgctcttca cctttttagt actcctactt ttaccactat ctatactttt ttttcgtagc     2160

catgtagtgt gatttttttt ctttattcta gtatttatta agtcaaatgg tttaaacgaa     2220

acccaaaaaa tatgaaaaat acacgtatgc gaggcacgta gccgatagag ctgcaaaac      2279


<210> 9
<211> 4713
<212> DNA
<213> Homo sapiens

<400> 9
gggcctccag tgcaatcact acgccctggg gcccggaaac cgttttccgg tctttcgctt       60

tcggctgggg cgtggaggcc gcggtgctgc gtaggccggg ccgggcgcag gaacagcccc      120

gtggcgccct ctctggccgc cgcccgggcg ggaaacgtcg ttccggggac cgggcgaccc      180

cgcagcgggg agcgcgccag gtccgcgcgg ggaagtgggc ggtgtgcggc cggcaccgcc      240

tcgcaccacg cccccgcggg cccgcacttt cccggagtgc accccgcggc cgccagccgg      300

ggcgatggcg gggctctggc tggggctcgt gtggcagaag ctgctgctgt ggggcgcggc      360

gagtgccctt tccctggccg gcgccagtct ggtcctgagc ctgctgcaga gggtggcgag      420

ctacgcgcgg aaatggcagc agatgcggcc catccccacg gtggcccgcg cctacccact      480

ggtgggccac gcgctgctga tgaagccgga cgggcgagaa ttttttcagc agatcattga      540

gtacacagag gaataccgcc acatgccgct gctgaagctc tgggtcgggc cagtgcccat      600

ggtggccctt tataatgcag aaaatgtgga ggtaatttta actagttcaa agcaaattga      660

caaatcctct atgtacaagt ttttagaacc atggcttggc ctaggacttc ttacaagtac      720

tggaaacaaa tggcgctcca ggagaaagat gttaacaccc actttccatt ttaccattct      780

ggaagatttc ttagatatca tgaatgaaca agcaaatata ttggttaaga aacttgaaaa      840

acacattaac caagaagcat ttaactgctt tttttacatc actctttgtg ccttagatat      900

catctgtgaa acagctatgg ggaagaatat tggtgctcaa agtaatgatg attccgagta      960

tgtccgtgca gtttatagaa tgagtgagat gatatttcga agaataaaga tgccctggct     1020

ttggcttgat ctctggtacc ttatgtttaa agaaggatgg gaacacaaaa agagccttca     1080

gatcctacat acttttacca acagtgtcat cgctgaacgg gccaatgaaa tgaacgccaa     1140

tgaagactgt agaggtgatg gcaggggctc tgccccctcc aaaaataaac gcagggcctt     1200

tcttgacttg cttttaagtg tgactgatga cgaagggaac aggctaagtc atgaagatat     1260

tcgagaagaa gttgacacct tcatgtttga ggggcacgat acaactgcag ctgcaataaa     1320

ctggtcctta tacctgttgg gttctaaccc agaagtccag aaaaaagtgg atcatgaatt     1380

ggatgacgtg tttgggaagt ctgaccgtcc cgctacagta gaagacctga agaaacttcg     1440

gtatctggaa tgtgttatta aggagaccct tcgccttttt ccttctgttc ctttatttgc     1500

ccgtagtgtt agtgaagatt gtgaagtggc aggttacaga gttctaaaag gcactgaagc     1560

cgtcatcatt ccctatgcat tgcacagaga tccgagatac ttccccaacc ccgaggagtt     1620

ccagcctgag cggttcttcc ccgagaatgc acaagggcgc catccatatg cctacgtgcc     1680

cttctctgct ggccccagga actgtatagg tcaaaagttt gctgtgatgg aagaaaagac     1740

cattctttcg tgcatcctga ggcacttttg gatagaatcc aaccagaaaa gagaagagct     1800

tggtctagaa ggacagttga ttcttcgtcc aagtaatggc atctggatca agttgaagag     1860

gagaaatgca gatgaacgct aactatatta ttgggttgtg cctttatcat gagaaaggtc     1920

tttattttaa gagatccttg tcatttacaa tttacagatc atgagttcaa tatgcttgaa     1980

tcccctagac ctaatttttc cttgatccca ctgatcttga catcaagtct aacaaagaaa     2040

aagttttgag ttttgtattt tcttttttct tttttcttta tttttttttt ttgaaaccgt     2100

gtctcactct gtcgcccagg ctggaggagt gcagtggtgt gatctcagct cactgcaacc     2160

tccacctccc aggttcaagc aattcttctg cctcagcctc ccaagtagct gggattacag     2220

gtgcctgcca ccatgcctgg ctaatttttt tgtattttta gtagaaacag ggtgtcacca     2280

tgttggccag actggtctca aactcctgac ctcaagtgat ccacctgcct cagcctccca     2340

aagtgctggg attatagtcg tgagccacca cgcctggcca gagtttttta tttttatcac     2400

caccatagat gttacagttg gctgtggtca caaaagtagt taattgtgtc agcacccaaa     2460

taaacatcta acaggtttct caacagagga atccacagtc caattccact tcaattgata     2520

gacccaaaaa atataattta atcaaagttc tagagttttt gtttgtttgt ttgagatgga     2580

gtcttgctct gtcgcccagg ctggaacgca gtggtgacat ctcggctcac tgcaacctcc     2640

acctcccagg ttcaagtgat tctcctgcct cagcctcctg agtagctggg actacaggcg     2700

cctgccacca cgcccagcta atttttgtat ttttagtaga gatggggttt caccatgttg     2760

gccaggatgg tcttgatctc ttgacctcgt gatctgcctg cctcggcctc ccaaagtgct     2820

ggcattacag gcatgagcca ccatgcctgg cccaaagttc tagaattttt taaaggtatt     2880

catggtgact caggaataca cacatacaca cacacacaca cacacacaca cacacacata     2940

cacacatata atttgaaaga ggtgagtatg tactctgact tcagctctca ggttttaaaa     3000

attatattag tgggaccagt tatgacaaga ataatcatta tagtactttt cagattttat     3060

aacctggagc agattatttt aagttgatta gtaggttctg ttacagtttt tcttttgatc     3120

gtgcacttat agtcttcatt taattcctca tagaatccca gtcaccttta tatatcatat     3180

tattggaaga gattcatctt cataatctcc agttttttca cagtgcctca cagagttaat     3240

catgcctttt ggagctagaa ggactttaga acttatctag ttatgctcct ttatattata     3300

agtaagggaa tagaatcaat aagacagttt ctgcccaaag tcatgttacc agttggtgac     3360

agagctggaa atacgtagag atctataccc ttaaatctct ccactcacat gctgatatac     3420

tttctactac aatatgctat agctttatgg aactcagggt gatgatcaga cgtgtcatta     3480

gaacatgagt cctctgcttc tgattcaggc atacttttgg gattcttcca tctttaaagg     3540

aaaaaggaag ccattcatct atatttagta acccagtaat atctcactta gtttagggtt     3600

agatctttag ttaattcaac cttatagatc atacttatga aggtgataac tgacacgtgt     3660

tcactgaatt ttaatttgat aggcaataca tctacccact ccattatttt ttaaaacttc     3720

atttaatagt ttaaacaaga ttggttttgt tttcaatttt tattcactct tcatagaatc     3780

acaattacct ttatatatca tatgttattg gaagagattc ctcagtaatc tccaatctct     3840

catagtgcct cacagggttg gtcaatggct tttggaactg gaaggacctt agaacttatc     3900

tgttatgctc ctgatagcca atagcagata gaagcttgca atcaagaggg taggacatgt     3960

gttcttcaat ggatatcaaa ggaagaggtt gcaaaccaaa gccatttggc aagccctgta     4020

gcctgggcca tttaagacag gggcggtctc agccaaattg cacccattta actatcccaa     4080

agagccacag tgcctacaac ccaggcccta agttgatgaa gaaaaagtca aggaaggagg     4140

tgatacaatt ggaaatattc ccatcaaatg gttaatctta tttagaaaat gggcatatta     4200

gaaaaagtcc ttccaagatg attttggata ataaaagttg tatttgtgga aattggtatt     4260

atctctgttt tatgcactta catttatccc ttacattttg tttttagtga ccctacatga     4320

cattaaattt aaagtaaaac attgtttaat gttacctttt ggcttgagaa tgtctttcag     4380

ctccagaatt attgttactc atattttaat cagtaagtca tttaagctat gacagagtag     4440

gaattgagaa attatttcat atgctacagt attgaaatgt ggatgctgcc ttgttttata     4500

agaagatgat caaggtttgt gtgcccatta cctttcctct gcctgaaaga cgtgtctcaa     4560

gaaaaataaa ttctatttta gatgcaggta ctgcatttta ttctaagaat tgatatcaat     4620

tcaaaacata gaaaactgta aaagataaat caggagatgg ctgattcata atgggtaata     4680

aaataaatag cactttcgag ctgaaaaaaa aaa                                  4713


<210> 10
<211> 154
<212> PRT
<213> Homo sapiens

<400> 10
Met Ala Thr Lys Ala Val Cys Val Leu Lys Gly Asp Gly Pro Val Gln 
1               5                   10                  15      


Gly Ile Ile Asn Phe Glu Gln Lys Glu Ser Asn Gly Pro Val Lys Val 
            20                  25                  30          


Trp Gly Ser Ile Lys Gly Leu Thr Glu Gly Leu His Gly Phe His Val 
        35                  40                  45              


His Glu Phe Gly Asp Asn Thr Ala Gly Cys Thr Ser Ala Gly Pro His 
    50                  55                  60                  


Phe Asn Pro Leu Ser Arg Lys His Gly Gly Pro Lys Asp Glu Glu Arg 
65                  70                  75                  80  


His Val Gly Asp Leu Gly Asn Val Thr Ala Asp Lys Asp Gly Val Ala 
                85                  90                  95      


Asp Val Ser Ile Glu Asp Ser Val Ile Ser Leu Ser Gly Asp His Cys 
            100                 105                 110         


Ile Ile Gly Arg Thr Leu Val Val His Glu Lys Ala Asp Asp Leu Gly 
        115                 120                 125             


Lys Gly Gly Asn Glu Glu Ser Thr Lys Thr Gly Asn Ala Gly Ser Arg 
    130                 135                 140                 


Leu Ala Cys Gly Val Ile Gly Ile Ala Gln 
145                 150                 


<210> 11
<211> 465
<212> DNA
<213> Homo sapiens

<400> 11
atggcgacga aggccgtgtg cgtgctgaag ggcgacggcc cagtgcaggg catcatcaat       60

ttcgagcaga aggaaagtaa tggaccagtg aaggtgtggg gaagcattaa aggactgact      120

gaaggcctgc atggattcca tgttcatgag tttggagata atacagcagg ctgtaccagt      180

gcaggtcctc actttaatcc tctatccaga aaacacggtg ggccaaagga tgaagagagg      240

catgttggag acttgggcaa tgtgactgct gacaaagatg gtgtggccga tgtgtctatt      300

gaagattctg tgatctcact ctcaggagac cattgcatca ttggccgcac actggtggtc      360

catgaaaaag cagatgactt gggcaaaggt ggaaatgaag aaagtacaaa gacaggaaac      420

gctggaagtc gtttggcttg tggtgtaatt gggatcgccc aataa                      465


<210> 12
<211> 414
<212> PRT
<213> Homo sapiens

<400> 12
Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190         


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205             


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220                 


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240 


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255     


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270         


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285             


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300                 


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335     


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350         


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365             


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380                 


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410                 


<210> 13
<211> 4236
<212> DNA
<213> Homo sapiens

<400> 13
ggtgggcggg gggaggaggc ggccctagcg ccattttgtg ggagcgaagc ggtggctggg       60

ctgcgcttgg gtccgtcgct gcttcggtgt ccctgtcggg cttcccagca gcggcctagc      120

gggaaaagta aaagatgtct gaatatattc gggtaaccga agatgagaac gatgagccca      180

ttgaaatacc atcggaagac gatgggacgg tgctgctctc cacggttaca gcccagtttc      240

caggggcgtg tgggcttcgc tacaggaatc cagtgtctca gtgtatgaga ggtgtccggc      300

tggtagaagg aattctgcat gccccagatg ctggctgggg aaatctggtg tatgttgtca      360

actatccaaa agataacaaa agaaaaatgg atgagacaga tgcttcatca gcagtgaaag      420

tgaaaagagc agtccagaaa acatccgatt taatagtgtt gggtctccca tggaaaacaa      480

ccgaacagga cctgaaagag tattttagta cctttggaga agttcttatg gtgcaggtca      540

agaaagatct taagactggt cattcaaagg ggtttggctt tgttcgtttt acggaatatg      600

aaacacaagt gaaagtaatg tcacagcgac atatgataga tggacgatgg tgtgactgca      660

aacttcctaa ttctaagcaa agccaagatg agcctttgag aagcagaaaa gtgtttgtgg      720

ggcgctgtac agaggacatg actgaggatg agctgcggga gttcttctct cagtacgggg      780

atgtgatgga tgtcttcatc cccaagccat tcagggcctt tgcctttgtt acatttgcag      840

atgatcagat tgcgcagtct ctttgtggag aggacttgat cattaaagga atcagcgttc      900

atatatccaa tgccgaacct aagcacaata gcaatagaca gttagaaaga agtggaagat      960

ttggtggtaa tccaggtggc tttgggaatc agggtggatt tggtaatagc agagggggtg     1020

gagctggttt gggaaacaat caaggtagta atatgggtgg tgggatgaac tttggtgcgt     1080

tcagcattaa tccagccatg atggctgccg cccaggcagc actacagagc agttggggta     1140

tgatgggcat gttagccagc cagcagaacc agtcaggccc atcgggtaat aaccaaaacc     1200

aaggcaacat gcagagggag ccaaaccagg ccttcggttc tggaaataac tcttatagtg     1260

gctctaattc tggtgcagca attggttggg gatcagcatc caatgcaggg tcgggcagtg     1320

gttttaatgg aggctttggc tcaagcatgg attctaagtc ttctggctgg ggaatgtaga     1380

cagtggggtt gtggttggtt ggtatagaat ggtgggaatt caaatttttc taaactcatg     1440

gtaagtatat tgtaaaatac atatgtacta agaattttca aaattggttt gttcagtgtg     1500

gagtatattc agcagtattt ttgacatttt tctttagaaa aaggaagagc taaaggaatt     1560

ttataagttt tgttacatga aaggttgaaa tattgagtgg ttgaaagtga actgctgttt     1620

gcctgattgg taaaccaaca cactacaatt gatatcaaaa ggtttctcct gtaatatttt     1680

atccctggac ttgtcaagtg aattctttgc atgttcaaaa cggaaaccat tgattagaac     1740

tacattcttt accccttgtt ttaatttgaa ccccaccata tggatttttt tccttaagaa     1800

aatctccttt taggagatca tggtgtcaca gtgtttggtt cttttgtttt gttttttaac     1860

acttgtctcc cctcatacac aaaagtacaa tatgaagcct tcatttaatc tctgcagttc     1920

atctcatttc aaatgtttat ggaagaagca cttcattgaa agtagtgctg taaatattct     1980

gccataggaa tactgtctac atgctttctc attcaagaat tcgtcatcac gcatcacagg     2040

ccgcgtcttt gacggtgggt gtcccatttt tatccgctac tctttatttc atggagtcgt     2100

atcaacgcta tgaacgcaag gctgtgatat ggaaccagaa ggctgtctga acttttgaaa     2160

ccttgtgtgg gattgatggt ggtgccgagg catgaaaggc tagtatgagc gagaaaagga     2220

gagagcgcgt gcagagactt ggtggtgcat aatggatatt ttttaacttg gcgagatgtg     2280

tctctcaatc ctgtggcttt ggtgagagag tgtgcagaga gcaatgatag caaataatgt     2340

acgaatgttt tttgcattca aaggacatcc acatctgttg gaagactttt aagtgagttt     2400

ttgttcttag ataacccaca ttagatgaat gtgttaagtg aaatgatact tgtactcccc     2460

ctaccccttt gtcaactgct gtgaatgctg tatggtgtgt gttctcttct gttactgata     2520

tgtaagtgtg gcaatgtgaa ctgaagctga tgggctgaga acatggactg agcttgtggt     2580

gtgctttgca ggaggacttg aagcagagtt caccagtgag ctcaggtgtc tcaaagaagg     2640

gtggaagttc taatgtctgt tagctaccca taagaatgct gtttgctgca gttctgtgtc     2700

ctgtgcttgg atgcttttta taagagttgt cattgttgga aattcttaaa taaaactgat     2760

ttaaataata tgtgtctttg ttttgcagcc ctgaatgcaa agaattcata gcagttaatt     2820

cccctttttt gacccttttg agatggaact ttcataaagt ttcttggcag tagtttattt     2880

tgcttcaaat aaacttattt gaaaagttgt ctcaagtcaa atggattcat cacctgtcat     2940

gcattgacac ctgataccca gacttaattg gtatttgttc ttgcattggc caaagtgaaa     3000

attttttttt ttcttttgaa atctagtttt gaataagtct gggtgaccgc acctaaaatg     3060

gtaagcagta ccctccggct ttttcttagt gcctctgtgc atttgggtga tgttctattt     3120

acatggcctg tgtaaatctc cattgggaag tcatgccttc taaaaagatt cttatttggg     3180

ggagtgggca aaatgttgat tattttctaa tgctttgtag caaagcatat caattgaaaa     3240

gggaatatca gcaccttcct agtttgggat ttgaaaagtg gaattaattg cagtagggat     3300

aaagtagaag aaaccacaaa ttatcttgtg cctgaaatcc attaagaggc ctgatagctt     3360

taagaattag ggtgggttgt ctgtctggaa gtgttaagtg gaatgggctt tgtcctccag     3420

gaggtggggg aatgtggtaa cattgaatac agttgaataa aatcgcttac aaaactcaca     3480

ctctcacaat gcattgttaa gtatgtaaaa gcaataacat tgattctctg ttgtactttt     3540

ttgtaactaa ttctgtgaga gttgagctca ttttctagtt ggaagaatgt gatatttgtt     3600

gtgttggtag tttacctaat gcccttacct aattagatta tgataaatag gtttgtcatt     3660

ttgcaagtta cataaacatt tatcaatgaa gtcatccttt agacttgtaa tcgccacatt     3720

gtttcattat tcagtttcct ctgtaaaggg atcttgagtt gttttaattt tttttttctg     3780

catctgaatc tgcatgattt ccaaaccctg taccatctga attttgcatt ttagcacttg     3840

cactattact cagcagcagt aacatggtaa cacttaaaat ggtactcggg gacctccaaa     3900

gactaaactg acaagccttc aaggagccca ggggtaagtt aacttgtcaa cggcatggtt     3960

taatcccttc tttacacttg tgtaaatttc agttactggt catagaaggc tttcaatgtt     4020

gagtggcctt ttattaacat gtttatggta ctgcatagat acgggtattt attttaccct     4080

aagaagattt tgaagtttaa aagtacttaa actatttggc aaagatttgt ttttaaaaat     4140

ctatttggtc aatctaaatg cattcattct aaaaaatttt ttgaaccaga taaataaaat     4200

ttttttttga caccacaaaa aaaaaaaaaa aaaaaa                               4236


<210> 14
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 14
His His His His His His 
1               5       


<210> 15
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
gcatgtattt ctaagctgct ctgctacggt cac                                    33


<210> 16
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
gtccactgct aagagcagct gccctc                                            26


<210> 17
<211> 1992
<212> DNA
<213> Drosophila melanogaster

<400> 17
cttgacttca accagtggcc ccagaactct tggaaccata taaaatgttg catgtggtca       60

atggcgattc acagttgagc actggcggct gatatagcaa cagtgccatc ttcagaagac      120

aaaaaggatt tgcaccagag gaccagggat caggagcaaa gaagcaacag caaccatggc      180

agtggaagta gttcaggaga cgctgcaaca agcggcgtcc agttcgtcga cgacggtcct      240

gggattcagt cctatgttaa ccaccttagt gggcaccctg gtggccatgg cattgtacga      300

gtattggcgc aggaatagcc gggaataccg catggttgcc aatataccat ccccaccgga      360

gttgcctatt ttgggacagg ctcatgtggc cgccggcttg agcaatgccg agatcctggc      420

cgttggcttg ggttacctca acaagtacgg agaaaccatg aaggcctggt tgggcaacgt      480

cctgttggtg tttctaacca atcccagtga catcgagttg atcctgagtg ggcaccagca      540

cttgaccaag gcggaggagt atcgctactt caagccctgg ttcggtgatg gtctactgat      600

cagcaatgga catcattggc gtcatcatcg taagatgatt gcccccacct tccaccagag      660

catcttgaag agcttcgtgc ctacatttgt ggatcactca aaggcggtag ttgccaggat      720

gggcttagaa gcgggcaaat cctttgatgt tcatgactat atgtcgcaga ccacggttga      780

catcctgttg tctaccgcca tgggtgtgaa gaagcttccg gagggtaaca agagtttcga      840

atacgcccaa gccgtcgtcg acatgtgtga tatcatacat aagaggcagg ttaaattact      900

gtaccgcctg gattccatct acaagtttac taagcttcgc gagaagggcg atcgcatgat      960

gaacatcatc ttgggtatga ccagcaaggt ggtcaaggat cgtaaggaga acttccaaga     1020

ggagtcacgt gcgattgttg aggagatttc tacacctgtt gccagcactc ccgcttccaa     1080

gaaggagggt cttcgcgatg atctggatga tatcgatgaa aatgatgtgg gcgccaagag     1140

gcgattggct cttctagatg ccatggtgga aatggctaag aaccccgata tcgagtggaa     1200

cgagaaggac atcatggatg aggtgaatac aattatgttt gagggccacg ataccacctc     1260

ggcgggatct agtttcgccc tctgcatgat gggaatccac aaggacatcc aggctaaagt     1320

cttcgccgaa cagaaggcca tcttcgggga taatatgctg agggattgca cctttgccga     1380

taccatggag atgaaatatt tggagcgcgt aattttagag actttgaggt tgtacccacc     1440

agtaccactt atcgccaggc gtctggacta cgacctgaag ttggccagtg gtccgtacac     1500

ggttcccaag ggcactacgg tcatcgtgct gcagtactgc gtgcacagac gtccagacat     1560

ctaccccaat cccaccaaat tcgatccgga caacttccta cccgagagga tggccaacag     1620

gcattactac tccttcattc cctttagcgc tggacccaga agctgtgtgg gccgcaagta     1680

cgccatgctg aagctaaagg tcctgctatc caccatcgtg aggaactata ttgtccactc     1740

caccgacacg gaggcagatt tcaagctgca ggctgacatc atcctaaagc ttgagaatgg     1800

attcaatgtc tcgttggaga agcgtcagta cgccacggtg gcctagaatc cagaaatcta     1860

ggaccccgac tacacacacg caaccccgaa cccgaaaccg gaatccagcc ctgtatatag     1920

atgatgaata ccgatgaata tcccaaaccg aaaacttgat gacgaactta taaatctaaa     1980

acaccgaata ag                                                         1992


<210> 18
<211> 503
<212> PRT
<213> Drosophila melanogaster

<400> 18
Ser Arg Glu Tyr Arg Met Val Ala Asn Ile Pro Ser Pro Pro Glu Leu 
1               5                   10                  15      


Pro Ile Leu Gly Gln Ala His Val Ala Ala Gly Leu Ser Asn Ala Glu 
            20                  25                  30          


Ile Leu Ala Val Gly Leu Gly Tyr Leu Asn Lys Tyr Gly Glu Thr Met 
        35                  40                  45              


Lys Ala Trp Leu Gly Asn Val Leu Leu Val Phe Leu Thr Asn Pro Ser 
    50                  55                  60                  


Asp Ile Glu Leu Ile Leu Ser Gly His Gln His Leu Thr Lys Ala Glu 
65                  70                  75                  80  


Glu Tyr Arg Tyr Phe Lys Pro Trp Phe Gly Asp Gly Leu Leu Ile Ser 
                85                  90                  95      


Asn Gly His His Trp Arg His His Arg Lys Met Ile Ala Pro Thr Phe 
            100                 105                 110         


His Gln Ser Ile Leu Lys Ser Phe Val Pro Thr Phe Val Asp His Ser 
        115                 120                 125             


Lys Ala Val Val Ala Arg Met Gly Leu Glu Ala Gly Lys Ser Phe Asp 
    130                 135                 140                 


Val His Asp Tyr Met Ser Gln Thr Thr Val Asp Ile Leu Leu Ser Thr 
145                 150                 155                 160 


Ala Met Gly Val Lys Lys Leu Pro Glu Gly Asn Lys Ser Phe Glu Tyr 
                165                 170                 175     


Ala Gln Ala Val Val Asp Met Cys Asp Ile Ile His Lys Arg Gln Val 
            180                 185                 190         


Lys Leu Leu Tyr Arg Leu Asp Ser Ile Tyr Lys Phe Thr Lys Leu Arg 
        195                 200                 205             


Glu Lys Gly Asp Arg Met Met Asn Ile Ile Leu Gly Met Thr Ser Lys 
    210                 215                 220                 


Val Val Lys Asp Arg Lys Glu Asn Phe Gln Glu Glu Ser Arg Ala Ile 
225                 230                 235                 240 


Val Glu Glu Ile Ser Thr Pro Val Ala Ser Thr Pro Ala Ser Lys Lys 
                245                 250                 255     


Glu Gly Leu Arg Asp Asp Leu Asp Asp Ile Asp Glu Asn Asp Val Gly 
            260                 265                 270         


Ala Lys Arg Arg Leu Ala Leu Leu Asp Ala Met Val Glu Met Ala Lys 
        275                 280                 285             


Asn Pro Asp Ile Glu Trp Asn Glu Lys Asp Ile Met Asp Glu Val Asn 
    290                 295                 300                 


Thr Ile Met Phe Glu Gly His Asp Thr Thr Ser Ala Gly Ser Ser Phe 
305                 310                 315                 320 


Ala Leu Cys Met Met Gly Ile His Lys Asp Ile Gln Ala Lys Val Phe 
                325                 330                 335     


Ala Glu Gln Lys Ala Ile Phe Gly Asp Asn Met Leu Arg Asp Cys Thr 
            340                 345                 350         


Phe Ala Asp Thr Met Glu Met Lys Tyr Leu Glu Arg Val Ile Leu Glu 
        355                 360                 365             


Thr Leu Arg Leu Tyr Pro Pro Val Pro Leu Ile Ala Arg Arg Leu Asp 
    370                 375                 380                 


Tyr Asp Leu Lys Leu Ala Ser Gly Pro Tyr Thr Val Pro Lys Gly Thr 
385                 390                 395                 400 


Thr Val Ile Val Leu Gln Tyr Cys Val His Arg Arg Pro Asp Ile Tyr 
                405                 410                 415     


Pro Asn Pro Thr Lys Phe Asp Pro Asp Asn Phe Leu Pro Glu Arg Met 
            420                 425                 430         


Ala Asn Arg His Tyr Tyr Ser Phe Ile Pro Phe Ser Ala Gly Pro Arg 
        435                 440                 445             


Ser Cys Val Gly Arg Lys Tyr Ala Met Leu Lys Leu Lys Val Leu Leu 
    450                 455                 460                 


Ser Thr Ile Val Arg Asn Tyr Ile Val His Ser Thr Asp Thr Glu Ala 
465                 470                 475                 480 


Asp Phe Lys Leu Gln Ala Asp Ile Ile Leu Lys Leu Glu Asn Gly Phe 
                485                 490                 495     


Asn Val Ser Leu Glu Lys Arg 
            500             


<210> 19
<211> 480
<212> PRT
<213> Homo sapiens

<400> 19
Ala Arg Lys Trp Gln Gln Met Arg Pro Ile Pro Thr Val Ala Arg Ala 
1               5                   10                  15      


Tyr Pro Leu Val Gly His Ala Leu Leu Met Lys Pro Asp Gly Arg Glu 
            20                  25                  30          


Phe Phe Gln Gln Ile Ile Glu Tyr Thr Glu Glu Tyr Arg His Met Pro 
        35                  40                  45              


Leu Leu Lys Leu Trp Val Gly Pro Val Pro Met Val Ala Leu Tyr Asn 
    50                  55                  60                  


Ala Glu Asn Val Glu Val Ile Leu Thr Ser Ser Lys Gln Ile Asp Lys 
65                  70                  75                  80  


Ser Ser Met Tyr Lys Phe Leu Glu Pro Trp Leu Gly Leu Gly Leu Leu 
                85                  90                  95      


Thr Ser Thr Gly Asn Lys Trp Arg Ser Arg Arg Lys Met Leu Thr Pro 
            100                 105                 110         


Thr Phe His Phe Thr Ile Leu Glu Asp Phe Leu Asp Ile Met Asn Glu 
        115                 120                 125             


Gln Ala Asn Ile Leu Val Lys Lys Leu Glu Lys His Ile Asn Gln Glu 
    130                 135                 140                 


Ala Phe Asn Cys Phe Phe Tyr Ile Thr Leu Cys Ala Leu Asp Ile Ile 
145                 150                 155                 160 


Cys Glu Thr Ala Met Gly Lys Asn Ile Gly Ala Gln Ser Asn Asp Asp 
                165                 170                 175     


Ser Glu Tyr Val Arg Ala Val Tyr Arg Met Ser Glu Met Ile Phe Arg 
            180                 185                 190         


Arg Ile Lys Met Pro Trp Leu Trp Leu Asp Leu Trp Tyr Leu Met Phe 
        195                 200                 205             


Lys Glu Gly Trp Glu His Lys Lys Ser Leu Gln Ile Leu His Thr Phe 
    210                 215                 220                 


Thr Asn Ser Val Ile Ala Glu Arg Ala Asn Glu Met Asn Ala Asn Glu 
225                 230                 235                 240 


Asp Cys Arg Gly Asp Gly Arg Gly Ser Ala Pro Ser Lys Asn Lys Arg 
                245                 250                 255     


Arg Ala Phe Leu Asp Leu Leu Leu Ser Val Thr Asp Asp Glu Gly Asn 
            260                 265                 270         


Arg Leu Ser His Glu Asp Ile Arg Glu Glu Val Asp Thr Phe Met Phe 
        275                 280                 285             


Glu Gly His Asp Thr Thr Ala Ala Ala Ile Asn Trp Ser Leu Tyr Leu 
    290                 295                 300                 


Leu Gly Ser Asn Pro Glu Val Gln Lys Lys Val Asp His Glu Leu Asp 
305                 310                 315                 320 


Asp Val Phe Gly Lys Ser Asp Arg Pro Ala Thr Val Glu Asp Leu Lys 
                325                 330                 335     


Lys Leu Arg Tyr Leu Glu Cys Val Ile Lys Glu Thr Leu Arg Leu Phe 
            340                 345                 350         


Pro Ser Val Pro Leu Phe Ala Arg Ser Val Ser Glu Asp Cys Glu Val 
        355                 360                 365             


Ala Gly Tyr Arg Val Leu Lys Gly Thr Glu Ala Val Ile Ile Pro Tyr 
    370                 375                 380                 


Ala Leu His Arg Asp Pro Arg Tyr Phe Pro Asn Pro Glu Glu Phe Gln 
385                 390                 395                 400 


Pro Glu Arg Phe Phe Pro Glu Asn Ala Gln Gly Arg His Pro Tyr Ala 
                405                 410                 415     


Tyr Val Pro Phe Ser Ala Gly Pro Arg Asn Cys Ile Gly Gln Lys Phe 
            420                 425                 430         


Ala Val Met Glu Glu Lys Thr Ile Leu Ser Cys Ile Leu Arg His Phe 
        435                 440                 445             


Trp Ile Glu Ser Asn Gln Lys Arg Glu Glu Leu Gly Leu Glu Gly Gln 
    450                 455                 460                 


Leu Ile Leu Arg Pro Ser Asn Gly Ile Trp Ile Lys Leu Lys Arg Arg 
465                 470                 475                 480 


<210> 20
<211> 551
<212> PRT
<213> Tenebrio molitor

<400> 20
Met Ser Val Val Glu Glu Ser Leu Ala Gln Ser Leu Gly Leu Gly Ser 
1               5                   10                  15      


Ser Val Val Phe Phe Leu Val Ser Ile Val Gly Ile Leu Thr Ile Tyr 
            20                  25                  30          


His Phe Trp Phe Gln Ser Leu Arg Ser Thr Lys Leu Gly Asn Lys Val 
        35                  40                  45              


Pro Gly Tyr Pro Pro Leu Pro Leu Phe Gly Asn Ala His Leu Ala Ile 
    50                  55                  60                  


Asn Lys Thr Pro Thr Glu Ile Leu Glu Met Ala Ile Glu Met Ala Lys 
65                  70                  75                  80  


Glu Lys Gly Ser Val Val Arg Val Trp Phe Gly Asn Lys Leu Gly Val 
                85                  90                  95      


Ala Leu Met Asp Pro Arg Asp Val Glu Val Ile Leu Gly Ser Asn Thr 
            100                 105                 110         


His Leu Glu Lys Ser Ser Glu Tyr Gly Phe Phe Glu Pro Trp Leu Gly 
        115                 120                 125             


Asp Gly Leu Leu Ile Ser Lys Gly Glu Arg Trp Arg Ser His Arg Lys 
    130                 135                 140                 


Met Ile Ala Pro Thr Phe His Gln Ser Ile Leu Lys Thr Phe Ile Pro 
145                 150                 155                 160 


Val Phe Asn Gln Asn Ala Lys Asp Leu Val Asp Gln Leu Arg Asn Asn 
                165                 170                 175     


Val Leu Asn Gln Ile Cys Asp Ile His Asp Tyr Met Ser Gly Ala Thr 
            180                 185                 190         


Val Asp Val Leu Leu Glu Thr Val Met Gly Val Lys Lys Thr Arg Asp 
        195                 200                 205             


Ser Glu Ser Ser Phe Lys Tyr Ala Lys Ala Val Met Asp Met Cys Ala 
    210                 215                 220                 


Ile Leu His Tyr Arg His Ile Tyr Phe Trp Met Arg Ser Asn Phe Ile 
225                 230                 235                 240 


Phe Ser Phe Ser Lys Lys Phe Lys Glu Gln Ser Ser Leu Leu Lys Ile 
                245                 250                 255     


Ile His Thr Leu Thr Asp Gln Val Ile Gln Lys Lys Lys Lys Ala Tyr 
            260                 265                 270         


Phe Glu Arg Ser Lys Ala Gly Asp Val Ser Leu Tyr Thr Thr Ala Val 
        275                 280                 285             


Lys Glu Thr Glu Glu Asp Ile Lys Lys Asn Glu Thr Gly Leu Ser Tyr 
    290                 295                 300                 


Gly Ser Ala Leu Arg Asp Asp Leu Asp Glu Asn Asp Glu Ala Val Gly 
305                 310                 315                 320 


Glu Lys Lys Arg Leu Ala Phe Leu Asp Phe Met Val Glu Ala Gly His 
                325                 330                 335     


Thr Glu Gly Asn Lys Leu Asn Asp Gln Asp Ile Arg Glu Glu Val Asn 
            340                 345                 350         


Thr Ile Met Phe Glu Gly His Asp Thr Thr Ala Ala Ala Ser Ser Phe 
        355                 360                 365             


Phe Leu Cys Ile Leu Gly Val Tyr Pro Asp Ile Gln Glu Lys Val Tyr 
    370                 375                 380                 


Gln Glu Leu Arg Asp Ile Phe Gln Asp Ser Asp Arg Pro Val Ser Phe 
385                 390                 395                 400 


Asn Asp Thr Met Glu Met Lys Tyr Leu Glu Arg Val Leu Leu Glu Thr 
                405                 410                 415     


Leu Arg Leu Tyr Pro Pro Val Pro Leu Ile Thr Arg Val Ile Asn Glu 
            420                 425                 430         


Glu Val Lys Leu Ala Ser Ala Asp Tyr Ile Leu Pro Ile Gly Thr Ser 
        435                 440                 445             


Val Gly Ile Pro Gln Tyr Leu Val His Arg Asn Pro Glu Tyr Phe Pro 
    450                 455                 460                 


Asn Pro Glu Lys Phe Asp Pro Asp Asn Phe Leu Pro Glu Arg Cys Gln 
465                 470                 475                 480 


Gln Arg His Tyr Tyr Ser Phe Ile Pro Phe Ser Ala Gly Pro Arg Ser 
                485                 490                 495     


Cys Val Gly Arg Lys Tyr Ala Met Leu Lys Leu Lys Ile Leu Leu Ala 
            500                 505                 510         


Gln Ile Val Arg Asn Phe Lys Ile Lys Ser Val Val Pro Glu Lys Asp 
        515                 520                 525             


Phe Gln Leu Gln Ala Asp Ile Ile Leu Lys Arg Ala Asp Gly Phe Arg 
    530                 535                 540                 


Val Ile Leu Glu Glu Arg Val 
545                 550     


<210> 21
<211> 554
<212> PRT
<213> Aedes aegypti

<400> 21
Met Ser Ala Glu Ile Val Ala Glu Arg Gly Ser Ser Leu Val Ser Leu 
1               5                   10                  15      


Ala Val Pro Met Val Ile Phe Met Thr Leu Val Leu Val Ala Ser Ala 
            20                  25                  30          


Leu Phe His Phe Trp Met Ile Ser Arg Arg Tyr Val Gln Leu Gly Asn 
        35                  40                  45              


Lys Ile Pro Gly Pro Arg Ala Tyr Pro Phe Ile Gly Asn Ala Asn Met 
    50                  55                  60                  


Leu Leu Gly Met Asn His Asn Glu Ile Met Glu Arg Ala Met Gln Leu 
65                  70                  75                  80  


Ser Tyr Ile Tyr Gly Ser Val Ala Arg Gly Trp Leu Gly Tyr His Leu 
                85                  90                  95      


Val Val Phe Leu Thr Glu Pro Ala Asp Ile Glu Ile Ile Leu Asn Ser 
            100                 105                 110         


Tyr Val His Leu Thr Lys Ser Ser Glu Tyr Arg Phe Phe Lys Pro Trp 
        115                 120                 125             


Leu Gly Asp Gly Leu Leu Ile Ser Ser Gly Glu Lys Trp Arg Ser His 
    130                 135                 140                 


Arg Lys Leu Ile Ala Pro Ala Phe His Met Asn Val Leu Lys Thr Phe 
145                 150                 155                 160 


Val Asp Val Phe Asn Asp Asn Ser Leu Ala Val Val Glu Arg Met Arg 
                165                 170                 175     


Lys Glu Val Gly Lys Glu Phe Asp Val His Asp Tyr Met Ser Glu Val 
            180                 185                 190         


Thr Val Asp Ile Leu Leu Glu Thr Ala Met Gly Ser Gln Arg Thr Ser 
        195                 200                 205             


Glu Ser Lys Glu Gly Phe Asp Tyr Ala Met Ala Val Met Lys Met Cys 
    210                 215                 220                 


Asp Ile Leu His Ser Arg Gln Leu Lys Phe His Leu Arg Met Asp Ser 
225                 230                 235                 240 


Val Phe Asn Phe Thr Lys Ile Lys Gln Glu Gln Glu Arg Leu Leu Gly 
                245                 250                 255     


Ile Ile His Gly Leu Thr Arg Lys Val Val Lys Gln Lys Lys Glu Leu 
            260                 265                 270         


Phe Glu Lys Asn Phe Ala Asp Gly Lys Leu Pro Ser Pro Ser Leu Ser 
        275                 280                 285             


Glu Ile Ile Ala Lys Glu Glu Ser Glu Ser Lys Glu Ser Leu Pro Val 
    290                 295                 300                 


Ile Ser Gln Gly Ser Leu Leu Arg Asp Asp Leu Asp Phe Asn Asp Glu 
305                 310                 315                 320 


Asn Asp Ile Gly Glu Lys Arg Arg Leu Ala Phe Leu Asp Leu Met Ile 
                325                 330                 335     


Glu Thr Ala Lys Ser Gly Ala Asp Leu Thr Asp Glu Glu Ile Lys Glu 
            340                 345                 350         


Glu Val Asp Thr Ile Met Phe Glu Gly His Asp Thr Thr Ala Ala Gly 
        355                 360                 365             


Ser Ser Phe Val Leu Cys Leu Leu Gly Ile His Gln Asp Val Gln Asp 
    370                 375                 380                 


Arg Val Tyr Lys Glu Ile Tyr Gln Ile Phe Gly Asn Ser Lys Arg Lys 
385                 390                 395                 400 


Ala Thr Phe Asn Asp Thr Leu Glu Met Lys Tyr Leu Glu Arg Val Ile 
                405                 410                 415     


Phe Glu Thr Leu Arg Met Tyr Pro Pro Val Pro Val Ile Ala Arg Lys 
            420                 425                 430         


Val Thr Gln Asp Val Arg Leu Ala Ser His Asp Tyr Val Val Pro Ala 
        435                 440                 445             


Gly Thr Thr Val Val Ile Gly Thr Tyr Lys Val His Arg Arg Ala Asp 
    450                 455                 460                 


Ile Tyr Pro Asn Pro Asp Val Phe Asn Pro Asp Asn Phe Leu Pro Glu 
465                 470                 475                 480 


Arg Thr Gln Asn Arg His Tyr Tyr Ser Tyr Ile Pro Phe Ser Ala Gly 
                485                 490                 495     


Pro Arg Ser Cys Val Gly Arg Lys Tyr Ala Met Leu Lys Leu Lys Val 
            500                 505                 510         


Leu Leu Ser Thr Ile Leu Arg Asn Tyr Arg Val Val Ser Asn Leu Lys 
        515                 520                 525             


Glu Ser Asp Phe Lys Leu Gln Gly Asp Ile Ile Leu Lys Arg Thr Asp 
    530                 535                 540                 


Gly Phe Arg Ile Gln Leu Glu Pro Arg Val 
545                 550                 


<210> 22
<211> 564
<212> PRT
<213> Diaphorina citri

<400> 22
Met Ser Thr Ala Ser Ala Glu Val Val Ala Ala Ser Gly Leu Thr Ala 
1               5                   10                  15      


Thr Thr Leu Phe Thr Tyr Leu Ile Val Pro Ala Leu Val Leu Trp Val 
            20                  25                  30          


Val Tyr Tyr Arg Met Ser Arg Arg Arg Leu Tyr Glu Leu Ala Ala Lys 
        35                  40                  45              


Leu Pro Gly Pro Glu Gly Leu Pro Leu Val Gly Lys Gly Leu Glu Phe 
    50                  55                  60                  


Ile Gly Ser Pro His Asp Ile Tyr Thr Arg Val Asn Lys Leu Gly Leu 
65                  70                  75                  80  


Glu Trp Glu Asp Lys Pro Val Val Lys Val Trp Val Gly Pro Arg Leu 
                85                  90                  95      


Leu Val Phe Leu Lys Asp Pro Arg Asp Val Glu Ile Ile Leu Ser Ser 
            100                 105                 110         


His Val His Ile Asp Lys Ser Pro Glu Tyr Arg Phe Phe Lys Pro Trp 
        115                 120                 125             


Leu Gly Asn Gly Leu Leu Ile Ser Thr Gly Glu Lys Trp Arg Ala His 
    130                 135                 140                 


Arg Lys Leu Ile Ala Pro Thr Phe His Leu Asn Val Leu Lys Ser Phe 
145                 150                 155                 160 


Leu Asp Leu Phe Asn Gln Asn Ser Arg Ala Val Val Glu Lys Met Arg 
                165                 170                 175     


Lys His Asn Gly Glu Ala Phe Asp Cys His Asp Tyr Met Ser Glu Cys 
            180                 185                 190         


Thr Val Glu Ile Leu Leu Glu Thr Ala Met Gly Val Asn Lys Lys Thr 
        195                 200                 205             


Gln Asn Gln Ser Gly Phe Glu Tyr Ala Met Ala Val Met Lys Met Cys 
    210                 215                 220                 


His Ile Leu His Ile Arg Ser Thr Lys Val Trp Leu Arg Pro Asp Phe 
225                 230                 235                 240 


Leu Phe Asn Leu Thr Ser Tyr Ala Lys Asp Gln Ala Arg Leu Leu Asn 
                245                 250                 255     


Ile Ile His Thr Leu Thr Lys Gln Val Leu Lys Lys Lys Lys Glu Thr 
            260                 265                 270         


Tyr Glu Lys Asn Lys Ser Ala Met Leu Asn Ser Ile Pro Ile Pro Thr 
        275                 280                 285             


Ile Gly Ile Lys Glu Glu Lys Lys Ala Glu Glu Lys Val Lys Asp Lys 
    290                 295                 300                 


Thr Val Val Glu Gly Leu Ser Tyr Gly Gln Ser Ser Gly Leu Lys Asp 
305                 310                 315                 320 


Asp Leu Asp Val Asp Glu Asp Val Gly Glu Lys Lys Arg Leu Ala Phe 
                325                 330                 335     


Leu Asp Leu Leu Ile Glu Ser Ala Gln Asn Gly Val Val Leu Thr Asp 
            340                 345                 350         


Glu Glu Ile Lys Glu Gln Val Asp Thr Ile Met Phe Glu Gly His Asp 
        355                 360                 365             


Thr Thr Ala Ala Gly Ser Ser Phe Phe Leu Cys Val Met Gly Thr His 
    370                 375                 380                 


Pro Glu Ile Gln Ala Lys Val Ile Gln Glu Ile Asp Glu Ile Phe Gly 
385                 390                 395                 400 


Asp Ser Asp Arg Pro Cys Thr Phe Gln Asp Thr Leu Glu Met Lys Tyr 
                405                 410                 415     


Leu Glu Arg Cys Ile Met Glu Thr Leu Arg Met Phe Pro Pro Val Pro 
            420                 425                 430         


Ile Ile Ala Arg Glu Leu Gln Gln Glu Val Lys Leu Asn Ser Cys Asp 
        435                 440                 445             


Leu Ser Ile Pro Ala Lys Cys Thr Val Val Ile Ala Thr Val Lys Leu 
    450                 455                 460                 


His Arg Gln Pro Asp Thr Tyr Pro Asn Pro Asp Val Tyr Asn Pro Asp 
465                 470                 475                 480 


Asn Phe Leu Pro Glu Asn Cys Ala Asn Arg His Tyr Tyr Ser Phe Val 
                485                 490                 495     


Pro Phe Ser Ala Gly Pro Arg Ser Cys Val Gly Arg Lys Tyr Ala Met 
            500                 505                 510         


Leu Lys Leu Lys Val Ile Leu Ser Thr Ile Leu Arg Asn Phe Thr Val 
        515                 520                 525             


His Ser Pro Thr Lys Leu Glu Asp Trp Lys Leu Gln Ala Asp Ile Ile 
    530                 535                 540                 


Leu Lys Arg Thr Asp Gly Phe Lys Ile Gln Leu Lys Pro Arg Lys Lys 
545                 550                 555                 560 


Gln Thr Val Ala 
                


<210> 23
<211> 546
<212> PRT
<213> Blattella germanica

<400> 23
Met Ser Val Thr Val Glu Thr Ala Thr Val Glu Ser Pro Ala Ser Ser 
1               5                   10                  15      


Ile Ser Thr Phe Met Val Leu Leu Val Ser Ala Val Ala Leu Phe Phe 
            20                  25                  30          


Ala Tyr Trp Lys Ile Ser Arg Arg Arg Phe Leu Gln Leu Ala Glu Lys 
        35                  40                  45              


Ile Pro Gly Pro Lys Gly Tyr Pro Ile Ile Gly Asn Ala Leu Asp Phe 
    50                  55                  60                  


Leu Gly Ser Ser Ser Gln Val Thr Asp Arg Met Ile Gln Ile Gly Phe 
65                  70                  75                  80  


Gln Phe Thr Thr Ile Ala Lys Val Trp Ile Leu His Lys Leu Val Val 
                85                  90                  95      


Phe Ile Ala Asp Pro Arg Asp Ile Glu Leu Ile Leu Gly Asn Ser Thr 
            100                 105                 110         


His Leu Glu Lys Ser Glu Glu Tyr Arg Phe Phe Lys Pro Trp Leu Gly 
        115                 120                 125             


Asp Gly Leu Leu Ile Ser Ser Gly Gln Lys Trp Lys Ser His Arg Lys 
    130                 135                 140                 


Leu Ile Ala Pro Thr Phe His Leu Asn Val Leu Lys Ser Phe Val Asp 
145                 150                 155                 160 


Leu Phe Asn Ala Asn Ser Arg Ala Val Cys Asp Lys Met Ala Lys Glu 
                165                 170                 175     


Asn Gly Arg Thr Phe Asp Cys His Asp Tyr Met Ser Glu Cys Thr Val 
            180                 185                 190         


Glu Val Leu Leu Glu Thr Ala Met Gly Val Ser Lys Lys Thr Gln Asn 
        195                 200                 205             


Lys Ser Gly Phe Glu Tyr Ala Met Ala Val Met Lys Met Cys Asn Ile 
    210                 215                 220                 


Leu His Leu Arg His Ser Lys Val Trp Leu Arg Pro Asp Trp Leu Phe 
225                 230                 235                 240 


Asn Leu Thr Lys Tyr Gly Lys Glu Gln Val Asp Leu Leu Asp Val Ile 
                245                 250                 255     


His Gly Leu Thr Lys Lys Val Ile Lys Asn Lys Lys Glu Ile Ile Ser 
            260                 265                 270         


Ser Gly Thr Lys Lys Tyr Ile Glu Glu Ser Val Thr Gln Glu Glu Lys 
        275                 280                 285             


Ala Ile Ala Ser Thr Pro Val Lys Gly Leu Arg Asp Asp Leu Asp Glu 
    290                 295                 300                 


Gln Asp Glu Asn Asp Val Gly Gln Lys Lys Arg Leu Ala Phe Leu Asp 
305                 310                 315                 320 


Leu Met Ile Glu Ser Ala Gln Asn Gly Val Val Leu Thr Asp Glu Glu 
                325                 330                 335     


Ile Lys Glu Glu Val Gly Thr Ile Met Phe Glu Gly His Asp Thr Thr 
            340                 345                 350         


Ala Ala Gly Ser Ser Phe Phe Leu Cys Leu Met Gly Ile His Gln Lys 
        355                 360                 365             


Tyr Gln Asp Met Cys Val Gln Glu Leu Asn Gln Ile Phe Gly Asp Ser 
    370                 375                 380                 


Asp Arg Pro Ala Thr Phe Ala Asp Thr Leu Glu Met Lys Phe Leu Glu 
385                 390                 395                 400 


Arg Cys Leu Leu Glu Ala Leu Arg Met Tyr Pro Pro Val Pro Val Ile 
                405                 410                 415     


Ala Arg Lys Leu Ala Glu Asp Leu Thr Leu Ala Ser Thr Gly Val Val 
            420                 425                 430         


Ile Pro Gln Gly Thr Thr Ile Val Val Ser Thr Val Lys Thr His Arg 
        435                 440                 445             


Leu Glu Glu His Trp Pro Asn Pro Asp Val Tyr Asp Pro Asp Asn His 
    450                 455                 460                 


Leu Pro Glu Lys Ala Ala Glu Arg His Tyr Tyr Ser Phe Val Pro Phe 
465                 470                 475                 480 


Ser Ala Gly Pro Arg Ser Cys Val Gly Arg Lys Tyr Ala Leu Leu Lys 
                485                 490                 495     


Leu Lys Ile Ile Leu Ser Thr Ile Leu Arg Asn Phe Lys Val His Ser 
            500                 505                 510         


Asp Ile Ser Glu Asp Glu Phe Lys Leu Gln Gly Asp Ile Ile Leu Lys 
        515                 520                 525             


Arg Ala Asp Gly Phe Met Ile Arg Leu Glu Pro Arg Lys Lys Thr Val 
    530                 535                 540                 


Ala Ala 
545     


<210> 24
<211> 552
<212> PRT
<213> Nasonia vitripennis

<400> 24
Met Asp Ala Val Pro Met Ser Thr Ser Tyr Leu Pro Ala Thr Leu Phe 
1               5                   10                  15      


Trp Pro Leu Val Leu Ile Ala Ala Ala Leu Ala Ala Val His Tyr Tyr 
            20                  25                  30          


Ile Glu Thr Ser Arg Ile Val Arg Leu Gly Asn Lys Leu Pro Gly Pro 
        35                  40                  45              


Lys Thr Val Pro Phe Phe Gly Asn Ala Leu Met Ala Leu Gly Val Gln 
    50                  55                  60                  


Pro Lys Asp Val Leu Thr Glu Val Met Lys Tyr Asp Ile Tyr Gly Asn 
65                  70                  75                  80  


Val Ala Arg Ala Phe Leu Gly Pro Lys Leu Val Val Phe Leu Val Asp 
                85                  90                  95      


Pro Arg Asp Val Glu Ile Ile Leu Gly Ser His Val His Ile Asp Lys 
            100                 105                 110         


Ser Pro Glu Tyr Arg Tyr Phe Ala Pro Trp Leu Gly Glu Gly Leu Leu 
        115                 120                 125             


Ile Ser Thr Gly Glu Lys Trp Arg Ser His Arg Lys Ile Ile Ala Pro 
    130                 135                 140                 


Thr Phe His Leu Asn Val Leu Lys Ser Phe Val Pro Leu Phe Tyr Glu 
145                 150                 155                 160 


Asn Ser Ile Asp Leu Val Lys Arg Leu Lys Ser Glu Val Gly Lys Glu 
                165                 170                 175     


Phe Asp Cys His Asp Tyr Met Ser Gly Ile Thr Val Asp Ile Leu Leu 
            180                 185                 190         


Glu Thr Ala Met Gly Val Arg Gly Thr Gln Lys Glu Lys Ser Ser Tyr 
        195                 200                 205             


Asp Tyr Ala Met Ala Val Met Lys Met Cys Asn Ile Ile His Gln Arg 
    210                 215                 220                 


Gln Tyr Asn Phe Met Leu Arg Leu Asp Thr Phe Phe Gln Phe Thr Ser 
225                 230                 235                 240 


Phe Ala Lys Gln Gln Thr Lys Phe Leu Asp Ile Ile His Gly Leu Thr 
                245                 250                 255     


Lys Arg Val Ile Lys Lys Arg Asn Val Glu Phe Lys Asp Lys Met Asp 
            260                 265                 270         


Ser Pro Met Met Asn Ser Ile Met Lys Glu Leu Lys Lys Asp Ser Thr 
        275                 280                 285             


Glu Ile Val Asp Glu Lys Gln Pro Glu Glu Gln Lys Met Arg Tyr Val 
    290                 295                 300                 


Arg Asp Asp Leu Asp Glu Ile Asp Glu Asn Asp Val Gly Glu Lys Arg 
305                 310                 315                 320 


Arg Leu Ala Phe Leu Asp Leu Met Leu Glu Met Arg Lys Asn Gly Glu 
                325                 330                 335     


Gln Leu Thr Asp Glu Glu Ile Lys Glu Glu Val Asp Thr Ile Met Phe 
            340                 345                 350         


Glu Gly His Asp Thr Thr Ala Ala Gly Ser Ser Phe Val Leu Cys Val 
        355                 360                 365             


Leu Gly Ile His Gln Asp Val Gln Asp Arg Val Ile Glu Glu Leu Asn 
    370                 375                 380                 


Glu Ile Phe Lys Gly Ser Asp Arg Pro Cys Thr Phe Gln Asp Thr Leu 
385                 390                 395                 400 


Glu Met Lys Tyr Leu Glu Arg Val Ile Leu Glu Thr Leu Arg Leu Phe 
                405                 410                 415     


Pro Pro Val Pro Ala Ile Ala Arg Gln Leu Asn Gln Asp Val Lys Leu 
            420                 425                 430         


Ala Ser Gly Asp Tyr Ile Leu Pro Ser Gly Cys Thr Val Val Ile Pro 
        435                 440                 445             


Gln Phe Lys Ile His Arg Leu Lys Glu Tyr Tyr Pro Asn Pro Asp Val 
    450                 455                 460                 


Phe Asp Pro Asp Asn Phe Leu Pro Asp Lys Thr Gln Asp Arg His Tyr 
465                 470                 475                 480 


Tyr Ala Tyr Ile Pro Phe Ser Ala Gly Pro Arg Ser Cys Val Gly Arg 
                485                 490                 495     


Lys Tyr Ala Met Leu Lys Leu Lys Val Leu Leu Ser Thr Ile Leu Arg 
            500                 505                 510         


Asn Tyr Lys Ile Asn Ser Asp Leu Thr Glu Glu Asp Phe Lys Leu Gln 
        515                 520                 525             


Val Asp Ile Ile Leu Lys Arg Ser Asp Gly Phe Arg Ile Gln Ile Glu 
    530                 535                 540                 


Pro Arg Asn Gln Ala Val Ile Val 
545                 550         


<210> 25
<211> 563
<212> PRT
<213> Spodoptera frugiperda

<400> 25
Met Thr Ser Leu Val Asp Glu Thr Glu Val Pro Ser Tyr Asn Thr Arg 
1               5                   10                  15      


Leu Ile Phe Tyr Pro Leu Leu Leu Leu Ala Ser Ser Ile Trp Ile Leu 
            20                  25                  30          


Tyr Arg Trp Gln Gln Lys Ser Arg Met Tyr Lys Phe Ala Glu Lys Ile 
        35                  40                  45              


Pro Gly Pro Ala Ile Ile Pro Phe Leu Gly Asn Ala Leu Leu Val Leu 
    50                  55                  60                  


Arg Lys Lys Pro Ser Glu Leu Val Lys Phe Ala Leu Glu Tyr Gly Glu 
65                  70                  75                  80  


Lys Phe Gly Asn Val Val Arg Val Trp Met Gly Ser Asn Leu Ile Val 
                85                  90                  95      


Phe Leu Thr Asp Pro Asn Asp Val Glu Ile Ile Leu Asn Ser Gln Val 
            100                 105                 110         


His Ile Asp Lys Ser Thr Glu Tyr Lys Phe Phe Lys Pro Trp Leu Gly 
        115                 120                 125             


Glu Gly Leu Leu Ile Ser Thr Gly Asp Lys Trp Arg Ala His Arg Lys 
    130                 135                 140                 


Met Ile Ala Pro Thr Phe His Ile Asn Ile Leu Lys Ser Phe Val Gly 
145                 150                 155                 160 


Ile Phe Asn Gln Asn Gly Lys Asn Val Val Glu Lys Met Arg Pro Glu 
                165                 170                 175     


Ile Gly Lys Glu Phe Asp Val His Asp Tyr Met Ser Gly Val Thr Val 
            180                 185                 190         


Asp Ile Leu Leu Glu Thr Ala Met Gly Ile Thr Arg Lys Thr Gln Asp 
        195                 200                 205             


Glu Ser Gly Phe Asp Tyr Ala Met Ala Val Met Lys Met Cys Asp Ile 
    210                 215                 220                 


Ile His Gln Arg Gln Tyr Lys Leu Trp Leu Arg Phe Asp Ser Ile Phe 
225                 230                 235                 240 


Asn Tyr Thr Asn Phe Ser Lys Gln Gln Lys Gln Leu Leu Asp Val Ile 
                245                 250                 255     


His Gly Leu Thr Asn Lys Val Ile Lys Asn Lys Lys Glu Thr Tyr Leu 
            260                 265                 270         


Glu Asn Lys Ala Lys Gly Val Val Pro Pro Thr Leu Glu Glu Leu Thr 
        275                 280                 285             


Lys Thr Thr Asp Glu Asn Val Leu Ala Asn Asn Asp Lys Ser Leu Ser 
    290                 295                 300                 


Glu Asp Val Phe Lys Gly Tyr Arg Asp Asp Leu Asp Phe Asn Asp Glu 
305                 310                 315                 320 


Asn Asp Ile Gly Glu Lys Lys Arg Leu Ala Phe Leu Asp Leu Met Ile 
                325                 330                 335     


Glu Ser Ser Gln Asn Gly Thr Asn Asn Ile Ser Asp His Glu Ile Lys 
            340                 345                 350         


Glu Glu Val Asp Thr Ile Met Phe Glu Gly His Asp Thr Thr Ala Ala 
        355                 360                 365             


Gly Ser Ser Phe Val Leu Cys Leu Leu Gly Val His Lys Gln Ile Gln 
    370                 375                 380                 


Asp Arg Val Tyr Asn Glu Leu Tyr Glu Ile Phe Gly Asp Ser Asp Arg 
385                 390                 395                 400 


Pro Ala Thr Phe Ala Asp Thr Leu Gln Met Lys Tyr Leu Glu Arg Val 
                405                 410                 415     


Ile Leu Glu Ser Leu Arg Met Tyr Pro Pro Val Pro Ile Ile Ala Arg 
            420                 425                 430         


Lys Leu Asn Arg Asp Val Lys Ile Ser Thr Asn Asn Tyr Val Leu Pro 
        435                 440                 445             


Ala Gly Ala Thr Val Val Val Gly Thr Leu Lys Ile His Arg Asn Pro 
    450                 455                 460                 


Gln Tyr Tyr Lys Asn Pro Asn Val Phe Asn Pro Asp Asn Phe Leu Pro 
465                 470                 475                 480 


Glu Asn Thr Ser Asn Arg His Tyr Tyr Ser Tyr Ile Pro Phe Ser Ala 
                485                 490                 495     


Gly Pro Arg Ser Cys Val Gly Arg Lys Tyr Ala Leu Leu Lys Leu Lys 
            500                 505                 510         


Val Leu Leu Ser Thr Ile Leu Arg Asn Tyr Lys Val Thr Ser Asp Val 
        515                 520                 525             


Thr Glu Asp Gln Phe Ala Leu Gln Ala Asp Ile Ile Leu Lys Arg Thr 
    530                 535                 540                 


Asp Gly Phe Arg Leu Lys Ile His Pro Arg Gln Arg Val Pro Ile Pro 
545                 550                 555                 560 


Asn Val Ala 
            


<210> 26
<211> 524
<212> PRT
<213> Oryctolagus cuniculus

<400> 26
Met Trp Leu Trp Leu Gly Leu Val Gly Gln Lys Leu Leu Phe Trp Gly 
1               5                   10                  15      


Ala Ala Ser Ala Val Ser Leu Ala Gly Ala Ser Leu Phe Leu Asn Leu 
            20                  25                  30          


Leu Gln Met Val Ala Ser Tyr Ala Arg Lys Trp Gln Gln Met Arg Pro 
        35                  40                  45              


Ile Pro Thr Ile Gly Arg Pro Tyr Pro Leu Val Gly His Ala Leu Tyr 
    50                  55                  60                  


Met Lys Pro Ser Gly Lys Glu Phe Phe Gln Gln Leu Ile Gln Tyr Thr 
65                  70                  75                  80  


Glu Glu Tyr Arg His Leu Pro Leu Leu Lys Leu Trp Leu Gly Pro Leu 
                85                  90                  95      


Pro Ile Val Ala Leu Tyr Asn Ala Glu Asn Val Glu Val Ile Leu Asn 
            100                 105                 110         


Ser Ser Lys Gln Ile Asn Lys Ser Ser Met Tyr Gln Phe Leu Glu Pro 
        115                 120                 125             


Trp Leu Gly Leu Gly Leu Leu Thr Ser Thr Gly Tyr Lys Trp Arg Ser 
    130                 135                 140                 


Arg Arg Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu Asp 
145                 150                 155                 160 


Phe Leu Asp Ile Met Asn Glu Gln Ala Asn Ile Leu Val His Lys Leu 
                165                 170                 175     


Glu Lys His Val Asp Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile Thr 
            180                 185                 190         


Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn Ile 
        195                 200                 205             


Gly Ala Gln Ser Asn Glu Asp Ser Glu Tyr Val Arg Ala Val Tyr Arg 
    210                 215                 220                 


Met Ser Asp Val Ile Phe Arg Arg Met Lys Met Pro Trp Leu Trp Leu 
225                 230                 235                 240 


Asp Leu Trp Tyr Leu Met Phe Lys Glu Gly Trp Glu His Lys Arg Cys 
                245                 250                 255     


Leu Lys Ile Leu His Arg Phe Thr Asn Asn Val Ile Ala Glu Arg Val 
            260                 265                 270         


Ser Glu Met Lys Thr Asp Glu Glu His Arg Asp Ala Asp Ser Asn Cys 
        275                 280                 285             


Ala Pro Ser Thr Met Lys Arg Lys Ala Phe Leu Asp Leu Leu Leu Thr 
    290                 295                 300                 


Val Thr Asp Glu Glu Gly Asn Lys Leu Ser His Glu Asp Ile Arg Glu 
305                 310                 315                 320 


Glu Val Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala Ala 
                325                 330                 335     


Ile Asn Trp Ser Leu Tyr Leu Leu Gly Ser His Pro Glu Val Gln Arg 
            340                 345                 350         


Lys Val Asp Asp Glu Leu Asp Glu Val Phe Gly Lys Ser Asp Arg Pro 
        355                 360                 365             


Ala Thr Ser Glu Asp Leu Lys Lys Leu Lys Tyr Leu Glu Cys Val Ile 
    370                 375                 380                 


Lys Glu Thr Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg Ser 
385                 390                 395                 400 


Leu Ser Asp Asp Cys Glu Val Ala Gly Phe Arg Val Val Lys Gly Thr 
                405                 410                 415     


Gln Ala Val Ile Val Pro Tyr Ala Leu His Arg Asp Pro Lys Tyr Phe 
            420                 425                 430         


Pro Asn Pro Glu Glu Phe Arg Pro Glu Arg Phe Phe Pro Glu Asn Ala 
        435                 440                 445             


Gln Gly Arg His Pro Tyr Ala Tyr Val Pro Phe Ser Ala Gly Pro Arg 
    450                 455                 460                 


Asn Cys Ile Gly Gln Lys Phe Ala Ile Met Glu Glu Lys Thr Ile Leu 
465                 470                 475                 480 


Ser Cys Ile Leu Arg Lys Leu Trp Val Glu Ser Asn Gln Lys Met Glu 
                485                 490                 495     


Glu Leu Gly Leu Ala Gly Glu Leu Ile Leu Arg Pro Thr Asn Gly Ile 
            500                 505                 510         


Trp Ile Lys Leu Lys Arg Arg Asn Ala Asp Lys Ala 
        515                 520                 


<210> 27
<211> 490
<212> PRT
<213> Canis lupus

<400> 27
Met Leu Ala Ser Tyr Ala Gln Lys Cys His Gln Met Arg Ala Phe Pro 
1               5                   10                  15      


Ser Leu Pro Gly Ala Tyr Pro Leu Val Glu His Ser Leu Leu Ile Asn 
            20                  25                  30          


Pro Pro Gly Thr Glu Phe Phe Gln Gln Val Ile Leu Tyr Ser Glu Glu 
        35                  40                  45              


Ser Arg His Leu Pro Leu Leu Lys Leu Trp Leu Gly Pro Ile Pro Ile 
    50                  55                  60                  


Val Ala Ile Tyr Ser Ala Glu Asn Val Glu Val Ile Leu Thr Ser Ser 
65                  70                  75                  80  


Arg Gln Ile Asp Lys Ser Tyr Val Tyr Lys Phe Leu Glu Pro Trp Leu 
                85                  90                  95      


Gly Leu Gly Leu Leu Thr Ser Thr Gly Asn Lys Trp Arg Ser Arg Arg 
            100                 105                 110         


Lys Met Leu Thr Pro Thr Phe His Phe Thr Ile Leu Glu Asp Phe Leu 
        115                 120                 125             


Asp Val Met Asn Glu His Ala Asn Ile Leu Val Asn Lys Leu Glu Lys 
    130                 135                 140                 


His Val Asn Gln Glu Ala Phe Asn Cys Phe Phe Tyr Ile Thr Leu Cys 
145                 150                 155                 160 


Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys Asn Ile Gly Ala 
                165                 170                 175     


Gln Asn Asn Glu Asp Ser Glu Tyr Val Arg Ala Ile Tyr Arg Met Ser 
            180                 185                 190         


Asp Thr Ile His Arg Arg Met Lys Met Pro Trp Leu Trp Leu Asp Phe 
        195                 200                 205             


Leu Phe Leu Met Phe Lys Glu Gly Arg Glu His Lys Arg Asn Leu Glu 
    210                 215                 220                 


Ile Leu His Asn Phe Thr Asn Asn Val Ile Thr Glu Arg Ala Ser Glu 
225                 230                 235                 240 


Leu Lys Arg Asp Glu Glu His Gly Ser Ala Asp Lys Asp Cys Ser Pro 
                245                 250                 255     


Ser Lys Asn Lys Arg Arg Ala Phe Leu Asp Leu Leu Leu Asn Val Thr 
            260                 265                 270         


Asp Asp Glu Gly Asn Lys Leu Arg His Glu Asp Val Arg Glu Glu Val 
        275                 280                 285             


Asp Thr Phe Met Phe Glu Gly His Asp Thr Thr Ala Ala Ala Ile Asn 
    290                 295                 300                 


Trp Ser Leu Tyr Leu Leu Gly Ser Tyr Pro Glu Val Gln Lys Gln Val 
305                 310                 315                 320 


Asp Ser Glu Leu Glu Asp Val Phe Gly Lys Ser Asp Arg Pro Ala Thr 
                325                 330                 335     


Leu Glu Asp Leu Lys Lys Leu Lys Tyr Leu Glu Cys Val Ile Lys Glu 
            340                 345                 350         


Ser Leu Arg Leu Phe Pro Ser Val Pro Leu Phe Ala Arg Asn Leu Asn 
        355                 360                 365             


Glu Asp Cys Val Val Ala Gly Tyr Lys Val Val Lys Gly Ser Gln Ala 
    370                 375                 380                 


Ile Ile Ile Pro Tyr Ala Leu His Arg Asp Pro Arg Tyr Phe Pro Asn 
385                 390                 395                 400 


Pro Glu Glu Phe Gln Pro Glu Arg Phe Phe Pro Glu Asn Leu Gln Gly 
                405                 410                 415     


Arg His Pro Tyr Ala Tyr Ile Pro Phe Ser Ala Gly Pro Arg Asn Cys 
            420                 425                 430         


Ile Gly Gln Arg Phe Ala Ile Met Glu Glu Lys Thr Val Leu Ser Cys 
        435                 440                 445             


Val Leu Arg His Phe Trp Val Glu Ser Asn Gln Lys Arg Glu Glu Leu 
    450                 455                 460                 


Gly Leu Ala Gly Glu Leu Ile Leu Arg Pro Thr Asn Gly Ile Trp Ile 
465                 470                 475                 480 


Lys Leu Lys Arg Arg Asn Ala Asp Glu Ser 
                485                 490 


<210> 28
<211> 530
<212> PRT
<213> Gallus gallus

<400> 28
Met Ala Met Glu Ile Thr Leu Gly Ser Met Glu Gly Thr Gln Leu Leu 
1               5                   10                  15      


Pro Trp Val Ala Gly Ala Ile Thr Leu Leu Leu Thr Val Val Thr Val 
            20                  25                  30          


His Phe Leu Pro Ser Leu Leu Asn Tyr Trp Trp Trp Trp Trp Val Met 
        35                  40                  45              


Lys Pro Ile Pro Gly Ile Arg Pro Cys Tyr Pro Phe Val Gly Asn Ala 
    50                  55                  60                  


Leu Leu Leu Glu Arg Asn Gly Glu Gly Phe Phe Lys Gln Leu Gln Gln 
65                  70                  75                  80  


Tyr Ala Asp Glu Phe Arg Lys Met Pro Met Phe Lys Leu Trp Leu Gly 
                85                  90                  95      


Pro Leu Pro Val Thr Val Leu Phe His Pro Asp Ser Val Glu Val Ile 
            100                 105                 110         


Leu Ser Ser Ser Lys His Ile Lys Lys Ser Phe Leu Tyr Thr Phe Leu 
        115                 120                 125             


His Pro Trp Leu Gly Thr Gly Leu Leu Thr Ser Thr Gly Asp Lys Trp 
    130                 135                 140                 


Arg Ser Arg Arg Lys Met Ile Thr Pro Thr Phe His Phe Ala Ile Leu 
145                 150                 155                 160 


Asn Asp Phe Leu Glu Val Met Asn Glu Gln Gly Gly Val Leu Leu Glu 
                165                 170                 175     


Lys Leu Glu Lys His Val Asp Lys Glu Pro Phe Asn Ile Phe Thr Asp 
            180                 185                 190         


Ile Thr Leu Cys Ala Leu Asp Ile Ile Cys Glu Thr Ala Met Gly Lys 
        195                 200                 205             


Asn Leu Gly Ala Gln Asp Asn Lys Asp Ser Glu Tyr Val Arg Ala Val 
    210                 215                 220                 


Tyr Arg Met Ser Asp Leu Ile Gln Gln Arg Gln Lys Ser Pro Trp Leu 
225                 230                 235                 240 


Trp His Asp Leu Met Tyr Leu Leu Phe Lys Glu Gly Arg Glu His Glu 
                245                 250                 255     


Arg Asn Leu Lys Ile Leu His Gly Phe Thr Asp Thr Val Ile Ala Glu 
            260                 265                 270         


Lys Val Ala Glu Leu Glu Asn Thr Lys Leu Thr Lys His Asp Thr Asp 
        275                 280                 285             


Val Asn Thr Glu Glu Glu Ser Gly Ser Lys Lys Arg Glu Ala Phe Leu 
    290                 295                 300                 


Asp Met Leu Leu Asn Ala Thr Asp Asp Glu Gly Lys Lys Leu Ser Tyr 
305                 310                 315                 320 


Lys Asp Ile Arg Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp 
                325                 330                 335     


Thr Thr Ala Ala Ala Met Asn Trp Val Leu Tyr Leu Leu Gly His His 
            340                 345                 350         


Pro Glu Ala Gln Lys Lys Val His Gln Glu Leu Asp Glu Val Phe Gly 
        355                 360                 365             


Asn Thr Glu Arg Pro Val Thr Val Asp Asp Leu Lys Lys Leu Arg Tyr 
    370                 375                 380                 


Leu Glu Cys Val Val Lys Glu Ala Leu Arg Leu Phe Pro Ser Val Pro 
385                 390                 395                 400 


Met Phe Ala Arg Ser Leu Gln Glu Asp Cys Tyr Ile Ser Gly Tyr Lys 
                405                 410                 415     


Leu Pro Lys Gly Thr Asn Val Leu Val Leu Thr Tyr Val Leu His Arg 
            420                 425                 430         


Asp Pro Glu Ile Phe Pro Glu Pro Asp Glu Phe Arg Pro Glu Arg Phe 
        435                 440                 445             


Phe Pro Glu Asn Ser Lys Gly Arg His Pro Tyr Ala Tyr Val Pro Phe 
    450                 455                 460                 


Ser Ala Gly Pro Arg Asn Cys Ile Gly Gln Arg Phe Ala Gln Met Glu 
465                 470                 475                 480 


Glu Lys Thr Leu Leu Ala Leu Ile Leu Arg Arg Phe Trp Val Asp Cys 
                485                 490                 495     


Ser Gln Lys Pro Glu Glu Leu Gly Leu Ser Gly Glu Leu Ile Leu Arg 
            500                 505                 510         


Pro Asn Asn Gly Ile Trp Val Gln Leu Lys Arg Arg Pro Lys Thr Val 
        515                 520                 525             


Thr Glu 
    530 


<210> 29
<211> 520
<212> PRT
<213> Xenopus tropicalis

<400> 29
Met Glu Leu Lys Gly Asp Val Asn Val Leu Leu Trp Thr Ala Val Ile 
1               5                   10                  15      


Val Val Leu Leu Thr Leu Leu Val Phe Ser Ala Leu Pro Val Leu Leu 
            20                  25                  30          


Asp Tyr Val Arg Lys Cys Lys Val Met Arg Leu Ile Pro Gly Pro Gly 
        35                  40                  45              


Pro Asn Tyr Pro Leu Val Gly Asp Ala Leu Leu Leu Lys Ser Asp Ala 
    50                  55                  60                  


Arg Glu Phe Phe Leu Gln Met Cys Glu Phe Ala Glu Asp Phe Arg Ser 
65                  70                  75                  80  


Glu Pro Leu Leu Lys Leu Trp Ile Gly Pro Ile Pro Phe Leu Ile Val 
                85                  90                  95      


Tyr His Ala Asp Thr Leu Glu Pro Phe Leu Ser Thr Ser Lys His Val 
            100                 105                 110         


Asp Lys Ala Tyr Leu Tyr Lys Phe Leu His Pro Trp Leu Gly Lys Gly 
        115                 120                 125             


Leu Leu Thr Ser Thr Gly Glu Lys Trp Arg Ile Arg Arg Lys Met Ile 
    130                 135                 140                 


Thr Pro Thr Phe His Phe Ala Ile Leu Ser Glu Phe Leu Glu Val Met 
145                 150                 155                 160 


Asn Glu Gln Ser Asn Val Leu Val Glu Lys Leu Gln Lys His Ala Asp 
                165                 170                 175     


Gly Glu Ser Phe Asp Cys Phe Ile Asp Val Thr Leu Cys Val Leu Asp 
            180                 185                 190         


Ile Ile Ser Glu Thr Ala Met Gly Arg Lys Ile Glu Ala Gln Ser Asn 
        195                 200                 205             


Lys Asp Ser Glu Tyr Val Gln Ala Ile Tyr Lys Met Ala Asp Phe Ile 
    210                 215                 220                 


Gln Asn Arg Gln Thr Lys Pro Trp Leu Trp Ser Asp Ser Leu Tyr Ala 
225                 230                 235                 240 


Tyr Leu Lys Glu Gly Lys Glu His Asn Lys Thr Leu Asn Ile Leu His 
                245                 250                 255     


Thr Phe Thr Asp Lys Ala Ile Leu Glu Arg Ala Glu Glu Leu Lys Lys 
            260                 265                 270         


Met Glu Val Lys Lys Gly Asp Ser Asp Pro Glu Ser Glu Lys Pro Lys 
        275                 280                 285             


Lys Arg Ser Ala Phe Leu Asp Met Leu Leu Met Ala Thr Asp Asp Ala 
    290                 295                 300                 


Gly Asn Lys Met Ser Tyr Lys Asp Ile Arg Glu Glu Val Asp Thr Phe 
305                 310                 315                 320 


Met Phe Glu Gly His Asp Thr Thr Ala Ser Ala Leu Asn Trp Thr Leu 
                325                 330                 335     


Phe Leu Leu Gly Ser His Pro Glu Ala Gln Arg Gln Val His Lys Glu 
            340                 345                 350         


Leu Asp Glu Val Phe Gly Lys Ser Asp Arg Pro Val Thr Met Asp Asp 
        355                 360                 365             


Leu Lys Lys Leu Arg Tyr Leu Glu Ala Val Ile Lys Glu Ser Leu Arg 
    370                 375                 380                 


Ile Phe Pro Pro Val Pro Met Phe Gly Arg Thr Val Thr Glu Asp Cys 
385                 390                 395                 400 


Thr Val Arg Gly Phe Lys Val Pro Lys Gly Val Asn Ile Ile Val Ile 
                405                 410                 415     


Thr Tyr Ser Leu His Arg Asp Pro Glu Tyr Phe Pro Glu Pro Glu Glu 
            420                 425                 430         


Phe Arg Pro Glu Arg Phe Phe Pro Glu Asn Ala Ser Gly Arg Asn Pro 
        435                 440                 445             


Tyr Ala Tyr Ile Pro Phe Ser Ala Gly Leu Arg Asn Cys Ile Gly Gln 
    450                 455                 460                 


Arg Phe Ala Leu Met Glu Glu Lys Val Val Leu Ser Ser Ile Leu Arg 
465                 470                 475                 480 


Lys Tyr Trp Val Glu Ala Thr Gln Lys Arg Asp Glu Cys Leu Leu Val 
                485                 490                 495     


Gly Glu Leu Ile Leu Arg Pro Gln Asp Gly Met Trp Ile Lys Leu Lys 
            500                 505                 510         


Asn Arg Glu Thr Ala Ser Ser Ala 
        515                 520 


<210> 30
<211> 510
<212> PRT
<213> Danio rerio

<400> 30
Met Gly Ile Leu Phe Gly Leu Tyr Ile Leu Gly Ile Leu Phe Thr Ala 
1               5                   10                  15      


Val Leu Leu Leu Leu Leu Ala Ser Thr Ala Tyr Asn Pro Leu Lys Asn 
            20                  25                  30          


Tyr Ile Gly Lys Trp Asn Glu Met Arg Pro Ile Pro Gly Met Ala Gly 
        35                  40                  45              


Ala Tyr Pro Ile Ile Gly Asn Ala Leu Gln Phe Lys Thr Asn Ala Gly 
    50                  55                  60                  


Asp Phe Phe Asn Gln Ile Ile Glu Gly Thr Asn Glu Asn Arg His Leu 
65                  70                  75                  80  


Pro Leu Ala Lys Val Trp Val Gly Pro Val Pro Phe Leu Ile Leu Tyr 
                85                  90                  95      


His Ala Glu Asn Ile Glu Val Val Leu Ser Asn Ser Arg His Leu Asp 
            100                 105                 110         


Lys Ser Tyr Ser Tyr Arg Phe Leu His Pro Trp Leu Gly Thr Gly Leu 
        115                 120                 125             


Leu Thr Ser Thr Gly Glu Lys Trp Arg Asn Arg Arg Lys Met Leu Thr 
    130                 135                 140                 


Pro Thr Phe His Phe Ser Ile Leu Ser Asp Phe Leu Glu Val Met Asn 
145                 150                 155                 160 


Glu Gln Thr Asp Ile Leu Ile Gln Lys Met Gln Lys Leu Glu Asp Gly 
                165                 170                 175     


Glu Pro Phe Asn Cys Phe Asn Phe Ile Thr Leu Cys Ala Leu Asp Ile 
            180                 185                 190         


Ile Cys Glu Thr Ala Met Gly Lys Lys Ile Tyr Ala Gln Ser Asn Ala 
        195                 200                 205             


Asp Ser Glu Tyr Val Gln Ser Val Tyr Lys Met Ser Asp Ile Ile Thr 
    210                 215                 220                 


Lys Arg Gln Arg Ala Pro Trp Leu Trp Pro Asp Trp Ile Tyr Asn Lys 
225                 230                 235                 240 


Leu Lys Glu Gly Lys Glu His Ala Lys Arg Leu Lys Ile Leu His Ser 
                245                 250                 255     


Phe Thr Ala Asn Val Ile Arg Glu Arg Ala Glu Phe Met Ser Ser Glu 
            260                 265                 270         


Pro Asp Ser Asp Ser Asp Gln Gly Glu Arg Lys Arg Gln Ala Phe Leu 
        275                 280                 285             


Asp Met Leu Leu Lys Thr Thr Tyr Glu Asn Gly Gln Lys Leu Ser His 
    290                 295                 300                 


Glu Asp Ile Gln Glu Glu Val Asp Thr Phe Met Phe Glu Gly His Asp 
305                 310                 315                 320 


Thr Thr Ala Ala Ser Met Asn Trp Ala Leu His Leu Ile Gly Ser His 
                325                 330                 335     


Pro Glu Val Gln Lys Ala Val Gln Ala Glu Leu Gln Glu Val Phe Gly 
            340                 345                 350         


Ser Ser Glu Arg His Val Gly Val Glu Asp Leu Lys Lys Leu Arg Tyr 
        355                 360                 365             


Leu Glu Cys Val Ile Lys Glu Ser Leu Arg Ile Phe Pro Ser Val Pro 
    370                 375                 380                 


Leu Phe Ala Arg Ser Ile Cys Glu Ala Cys His Ile Asn Gly Phe Lys 
385                 390                 395                 400 


Val Pro Lys Gly Val Asn Ala Val Ile Ile Pro Tyr Ala Leu His Arg 
                405                 410                 415     


Asp Pro Arg Tyr Phe Pro Glu Pro Glu Glu Phe Gln Pro Glu Arg Phe 
            420                 425                 430         


Met Pro Glu Asn Ser Lys Gly Arg His Pro Tyr Ala Tyr Ile Pro Phe 
        435                 440                 445             


Ser Ala Gly Pro Arg Asn Cys Ile Gly Gln Arg Phe Ala Met Met Glu 
    450                 455                 460                 


Glu Lys Val Val Leu Ala Thr Ile Leu Arg His Phe Asp Val Glu Ala 
465                 470                 475                 480 


Cys Gln Ser Arg Glu Glu Leu Arg Pro Leu Gly Glu Leu Ile Leu Arg 
                485                 490                 495     


Pro Glu Lys Gly Ile Trp Ile Lys Leu Gln Arg Arg Ser Lys 
            500                 505                 510 


