                               SEQUENCE LISTING

<110> GRITSTONE ONCOLOGY, INC.
 
<120> REDUCING JUNCTION EPITOPE PRESENTATION FOR NEOANTIGENS

<130> 32669-41062/WO

<140> PCT/US2018/062294
<141> 2018-11-21

<150> 62/590,045
<151> 2017-11-22

<160> 76    

<170> PatentIn version 3.5

<210> 1
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Tyr Val Tyr Val Ala Asp Val Ala Ala Lys 
1               5                   10  


<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Tyr Glu Met Phe Asn Asp Lys Ser Gln Arg Ala Pro Asp Asp Lys Met 
1               5                   10                  15      


Phe 
    


<210> 3
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Tyr Glu Met Phe Asn Asp Lys Ser Phe 
1               5                   


<210> 4
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Pyrrolysine

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Leu or Ile

<400> 4
His Arg Xaa Glu Ile Phe Ser His Asp Phe Xaa 
1               5                   10      


<210> 5
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Leu or Ile

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Leu or Ile

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Pyrrolysine 

<400> 5
Phe Xaa Ile Glu Xaa Phe Xaa Glu Ser Ser 
1               5                   10  


<210> 6
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Pyrrolysine 

<400> 6
Asn Glu Ile Xaa Arg Glu Ile Arg Glu Ile 
1               5                   10  


<210> 7
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Leu or Ile

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Leu or Ile

<220>
<221> MOD_RES
<222> (15)..(15)
<223> Selenocysteine 

<220>
<221> MOD_RES
<222> (21)..(21)
<223> Leu or Ile

<220>
<221> MOD_RES
<222> (27)..(27)
<223> Leu or Ile

<400> 7
Xaa Phe Lys Ser Ile Phe Glu Met Met Ser Xaa Asp Ser Ser Xaa Ile 
1               5                   10                  15      


Phe Leu Lys Ser Xaa Phe Ile Glu Ile Phe Xaa 
            20                  25          


<210> 8
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (11)..(11)
<223> Pyrrolysine 

<400> 8
Lys Asn Phe Leu Glu Asn Phe Ile Glu Ser Xaa Phe Ile 
1               5                   10              


<210> 9
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Pyrrolysine 

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Leu or Ile 

<400> 9
Phe Xaa Glu Ile Phe Asn Asp Lys Ser Leu Asp Lys Phe Xaa Ile 
1               5                   10                  15  


<210> 10
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pyrrolysine 

<220>
<221> MOD_RES
<222> (16)..(16)
<223> Leu or Ile 

<400> 10
Gln Cys Glu Ile Xaa Trp Ala Arg Glu Phe Leu Lys Glu Ile Gly Xaa 
1               5                   10                  15      


<210> 11
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Selenocysteine 

<400> 11
Phe Ile Glu Xaa His Phe Trp Ile 
1               5               


<210> 12
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (7)..(7)
<223> Leu or Ile 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Selenocysteine 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Leu or Ile 

<400> 12
Phe Glu Trp Arg His Arg Xaa Thr Arg Xaa Xaa Arg 
1               5                   10          


<210> 13
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Leu or Ile 

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pyrrolysine 

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Leu or Ile 

<400> 13
Gln Ile Glu Xaa Xaa Glu Ile Xaa Glu 
1               5                   


<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pyrrolysine 

<400> 14
Gln Cys Glu Ile Xaa Trp Ala Arg Glu 
1               5                   


<210> 15
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Leu or Ile 

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Pyrrolysine 

<220>
<221> MOD_RES
<222> (11)..(11)
<223> Leu or Ile 

<400> 15
Phe Xaa Glu Leu Phe Ile Ser Asx Xaa Ser Xaa Phe Ile Glu 
1               5                   10                  


<210> 16
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pyrrolysine 

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Leu or Ile 

<400> 16
Ile Glu Phe Arg Xaa Glu Ile Phe Xaa Glu Phe 
1               5                   10      


<210> 17
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pyrrolysine 

<220>
<221> MOD_RES
<222> (9)..(9)
<223> Leu or Ile 

<400> 17
Ile Glu Phe Arg Xaa Glu Ile Phe Xaa 
1               5                   


<210> 18
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (4)..(4)
<223> Pyrrolysine 

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Leu or Ile 

<400> 18
Glu Phe Arg Xaa Glu Ile Phe Xaa Glu 
1               5                   


<210> 19
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (3)..(3)
<223> Pyrrolysine 

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Leu or Ile 

<400> 19
Phe Arg Xaa Glu Ile Phe Xaa Glu Phe 
1               5                   


<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Ser Ile Asn Phe Glu Lys Leu 
1               5           


<210> 21
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Leu Leu Leu Leu Leu Val Val Val Val 
1               5                   


<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Glu Lys Leu Ala Ala Tyr Leu Leu Leu 
1               5                   


<210> 23
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Lys Leu Ala Ala Tyr Leu Leu Leu Leu Leu 
1               5                   10  


<210> 24
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Phe Glu Lys Leu Ala Ala Tyr Leu 
1               5               


<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Ala Ala Tyr Leu Leu Leu Leu Leu 
1               5               


<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Tyr Leu Leu Leu Leu Leu Val Val Val 
1               5                   


<210> 27
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Val Val Val Val Ala Ala Tyr Ser Ile Asn 
1               5                   10  


<210> 28
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Val Val Val Val Ala Ala Tyr 
1               5           


<210> 29
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Ala Tyr Ser Ile Asn Phe Glu Lys 
1               5               


<210> 30
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Tyr Asn Tyr Ser Tyr Trp Ile Ser Ile Phe Ala His Thr Met Trp Tyr 
1               5                   10                  15      


Asn Ile Trp His Val Gln Trp Asn Lys 
            20                  25  


<210> 31
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Ile Glu Ala Leu Pro Tyr Val Phe Leu Gln Asp Gln Phe Glu Leu Arg 
1               5                   10                  15      


Leu Leu Lys Gly Glu Gln Gly Asn Asn 
            20                  25  


<210> 32
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Asp Ser Glu Glu Thr Asn Thr Asn Tyr Leu His Tyr Cys His Phe His 
1               5                   10                  15      


Trp Thr Trp Ala Gln Gln Thr Thr Val 
            20                  25  


<210> 33
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Gly Met Leu Ser Gln Tyr Glu Leu Lys Asp Cys Ser Leu Gly Phe Ser 
1               5                   10                  15      


Trp Asn Asp Pro Ala Lys Tyr Leu Arg 
            20                  25  


<210> 34
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Val Arg Ile Asp Lys Phe Leu Met Tyr Val Trp Tyr Ser Ala Pro Phe 
1               5                   10                  15      


Ser Ala Tyr Pro Leu Tyr Gln Asp Ala 
            20                  25  


<210> 35
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Cys Val His Ile Tyr Asn Asn Tyr Pro Arg Met Leu Gly Ile Pro Phe 
1               5                   10                  15      


Ser Val Met Val Ser Gly Phe Ala Met 
            20                  25  


<210> 36
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Phe Thr Phe Lys Gly Asn Ile Trp Ile Glu Met Ala Gly Gln Phe Glu 
1               5                   10                  15      


Arg Thr Trp Asn Tyr Pro Leu Ser Leu 
            20                  25  


<210> 37
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Ala Asn Asp Asp Thr Pro Asp Phe Arg Lys Cys Tyr Ile Glu Asp His 
1               5                   10                  15      


Ser Phe Arg Phe Ser Gln Thr Met Asn 
            20                  25  


<210> 38
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Ala Ala Gln Tyr Ile Ala Cys Met Val Asn Arg Gln Met Thr Ile Val 
1               5                   10                  15      


Tyr His Leu Thr Arg Trp Gly Met Lys 
            20                  25  


<210> 39
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Lys Tyr Leu Lys Glu Phe Thr Gln Leu Leu Thr Phe Val Asp Cys Tyr 
1               5                   10                  15      


Met Trp Ile Thr Phe Cys Gly Pro Asp 
            20                  25  


<210> 40
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Ala Met His Tyr Arg Thr Asp Ile His Gly Tyr Trp Ile Glu Tyr Arg 
1               5                   10                  15      


Gln Val Asp Asn Gln Met Trp Asn Thr 
            20                  25  


<210> 41
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Thr His Val Asn Glu His Gln Leu Glu Ala Val Tyr Arg Phe His Gln 
1               5                   10                  15      


Val His Cys Arg Phe Pro Tyr Glu Asn 
            20                  25  


<210> 42
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Gln Thr Phe Ser Glu Cys Leu Phe Phe His Cys Leu Lys Val Trp Asn 
1               5                   10                  15      


Asn Val Lys Tyr Ala Lys Ser Leu Lys 
            20                  25  


<210> 43
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Ser Phe Ser Ser Trp His Tyr Lys Glu Ser His Ile Ala Leu Leu Met 
1               5                   10                  15      


Ser Pro Lys Lys Asn His Asn Asn Thr 
            20                  25  


<210> 44
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Ile Leu Asp Gly Ile Met Ser Arg Trp Glu Lys Val Cys Thr Arg Gln 
1               5                   10                  15      


Thr Arg Tyr Ser Tyr Cys Gln Cys Ala 
            20                  25  


<210> 45
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Tyr Arg Ala Ala Gln Met Ser Lys Trp Pro Asn Lys Tyr Phe Asp Phe 
1               5                   10                  15      


Pro Glu Phe Met Ala Tyr Met Pro Ile 
            20                  25  


<210> 46
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Pro Arg Pro Gly Met Pro Cys Gln His His Asn Thr His Gly Leu Asn 
1               5                   10                  15      


Asp Arg Gln Ala Phe Asp Asp Phe Val 
            20                  25  


<210> 47
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
His Asn Ile Ile Ser Asp Glu Thr Glu Val Trp Glu Gln Ala Pro His 
1               5                   10                  15      


Ile Thr Trp Val Tyr Met Trp Cys Arg 
            20                  25  


<210> 48
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Ala Tyr Ser Trp Pro Val Val Pro Met Lys Trp Ile Pro Tyr Arg Ala 
1               5                   10                  15      


Leu Cys Ala Asn His Pro Pro Gly Thr 
            20                  25  


<210> 49
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
His Val Met Pro His Val Ala Met Asn Ile Cys Asn Trp Tyr Glu Phe 
1               5                   10                  15      


Leu Tyr Arg Ile Ser His Ile Gly Arg 
            20                  25  


<210> 50
<211> 484
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 50
Thr His Val Asn Glu His Gln Leu Glu Ala Val Tyr Arg Phe His Gln 
1               5                   10                  15      


Val His Cys Arg Phe Pro Tyr Glu Asn Ala Met His Tyr Gln Met Trp 
            20                  25                  30          


Asn Thr Tyr Arg Ala Ala Gln Met Ser Lys Trp Pro Asn Lys Tyr Phe 
        35                  40                  45              


Asp Phe Pro Glu Phe Met Ala Tyr Met Pro Ile Cys Val His Ile Tyr 
    50                  55                  60                  


Asn Asn Tyr Pro Arg Met Leu Gly Ile Pro Phe Ser Val Met Val Ser 
65                  70                  75                  80  


Gly Phe Ala Met Ala Tyr Ser Trp Pro Val Val Pro Met Lys Trp Ile 
                85                  90                  95      


Pro Tyr Arg Ala Leu Cys Ala Asn His Pro Pro Gly Thr Ala Asn Asp 
            100                 105                 110         


Asp Thr Pro Asp Phe Arg Lys Cys Tyr Ile Glu Asp His Ser Phe Arg 
        115                 120                 125             


Phe Ser Gln Thr Met Asn Ile Glu Ala Leu Pro Tyr Val Phe Leu Gln 
    130                 135                 140                 


Asp Gln Phe Glu Leu Arg Leu Leu Lys Gly Glu Gln Gly Asn Asn Asp 
145                 150                 155                 160 


Ser Glu Glu Thr Asn Thr Asn Tyr Leu His Tyr Cys His Phe His Trp 
                165                 170                 175     


Thr Trp Ala Gln Gln Thr Thr Val Ile Leu Asp Gly Ile Met Ser Arg 
            180                 185                 190         


Trp Glu Lys Val Cys Thr Arg Gln Thr Arg Tyr Ser Tyr Cys Gln Cys 
        195                 200                 205             


Ala Phe Thr Phe Lys Gly Asn Ile Trp Ile Glu Met Ala Gly Gln Phe 
    210                 215                 220                 


Glu Arg Thr Trp Asn Tyr Pro Leu Ser Leu Ser Phe Ser Ser Trp His 
225                 230                 235                 240 


Tyr Lys Glu Ser His Ile Ala Leu Leu Met Ser Pro Lys Lys Asn His 
                245                 250                 255     


Asn Asn Thr Gln Thr Phe Ser Glu Cys Leu Phe Phe His Cys Leu Lys 
            260                 265                 270         


Val Trp Asn Asn Val Lys Tyr Ala Lys Ser Leu Lys His Val Met Pro 
        275                 280                 285             


His Val Ala Met Asn Ile Cys Asn Trp Tyr Glu Phe Leu Tyr Arg Ile 
    290                 295                 300                 


Ser His Ile Gly Arg His Asn Ile Ile Ser Asp Glu Thr Glu Val Trp 
305                 310                 315                 320 


Glu Gln Ala Pro His Ile Thr Trp Val Tyr Met Trp Cys Arg Val Arg 
                325                 330                 335     


Ile Asp Lys Phe Leu Met Tyr Val Trp Tyr Ser Ala Pro Phe Ser Ala 
            340                 345                 350         


Tyr Pro Leu Tyr Gln Asp Ala Lys Tyr Leu Lys Glu Phe Thr Gln Leu 
        355                 360                 365             


Leu Thr Phe Val Asp Cys Tyr Met Trp Ile Thr Phe Cys Gly Pro Asp 
    370                 375                 380                 


Ala Ala Gln Tyr Ile Ala Cys Met Val Asn Arg Gln Met Thr Ile Val 
385                 390                 395                 400 


Tyr His Leu Thr Arg Trp Gly Met Lys Tyr Asn Tyr Ser Tyr Trp Ile 
                405                 410                 415     


Ser Ile Phe Ala His Thr Met Trp Tyr Asn Ile Trp His Val Gln Trp 
            420                 425                 430         


Asn Lys Gly Met Leu Ser Gln Tyr Glu Leu Lys Asp Cys Ser Leu Gly 
        435                 440                 445             


Phe Ser Trp Asn Asp Pro Ala Lys Tyr Leu Arg Pro Arg Pro Gly Met 
    450                 455                 460                 


Pro Cys Gln His His Asn Thr His Gly Leu Asn Asp Arg Gln Ala Phe 
465                 470                 475                 480 


Asp Asp Phe Val 
                


<210> 51
<211> 484
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 51
Ile Glu Ala Leu Pro Tyr Val Phe Leu Gln Asp Gln Phe Glu Leu Arg 
1               5                   10                  15      


Leu Leu Lys Gly Glu Gln Gly Asn Asn Ile Leu Asp Gly Ile Met Ser 
            20                  25                  30          


Arg Trp Glu Lys Val Cys Thr Arg Gln Thr Arg Tyr Ser Tyr Cys Gln 
        35                  40                  45              


Cys Ala His Val Met Pro His Val Ala Met Asn Ile Cys Asn Trp Tyr 
    50                  55                  60                  


Glu Phe Leu Tyr Arg Ile Ser His Ile Gly Arg Thr His Val Asn Glu 
65                  70                  75                  80  


His Gln Leu Glu Ala Val Tyr Arg Phe His Gln Val His Cys Arg Phe 
                85                  90                  95      


Pro Tyr Glu Asn Phe Thr Phe Lys Gly Asn Ile Trp Ile Glu Met Ala 
            100                 105                 110         


Gly Gln Phe Glu Arg Thr Trp Asn Tyr Pro Leu Ser Leu Ala Met His 
        115                 120                 125             


Tyr Gln Met Trp Asn Thr Ser Phe Ser Ser Trp His Tyr Lys Glu Ser 
    130                 135                 140                 


His Ile Ala Leu Leu Met Ser Pro Lys Lys Asn His Asn Asn Thr Val 
145                 150                 155                 160 


Arg Ile Asp Lys Phe Leu Met Tyr Val Trp Tyr Ser Ala Pro Phe Ser 
                165                 170                 175     


Ala Tyr Pro Leu Tyr Gln Asp Ala Gln Thr Phe Ser Glu Cys Leu Phe 
            180                 185                 190         


Phe His Cys Leu Lys Val Trp Asn Asn Val Lys Tyr Ala Lys Ser Leu 
        195                 200                 205             


Lys Tyr Arg Ala Ala Gln Met Ser Lys Trp Pro Asn Lys Tyr Phe Asp 
    210                 215                 220                 


Phe Pro Glu Phe Met Ala Tyr Met Pro Ile Ala Tyr Ser Trp Pro Val 
225                 230                 235                 240 


Val Pro Met Lys Trp Ile Pro Tyr Arg Ala Leu Cys Ala Asn His Pro 
                245                 250                 255     


Pro Gly Thr Cys Val His Ile Tyr Asn Asn Tyr Pro Arg Met Leu Gly 
            260                 265                 270         


Ile Pro Phe Ser Val Met Val Ser Gly Phe Ala Met His Asn Ile Ile 
        275                 280                 285             


Ser Asp Glu Thr Glu Val Trp Glu Gln Ala Pro His Ile Thr Trp Val 
    290                 295                 300                 


Tyr Met Trp Cys Arg Ala Ala Gln Tyr Ile Ala Cys Met Val Asn Arg 
305                 310                 315                 320 


Gln Met Thr Ile Val Tyr His Leu Thr Arg Trp Gly Met Lys Tyr Asn 
                325                 330                 335     


Tyr Ser Tyr Trp Ile Ser Ile Phe Ala His Thr Met Trp Tyr Asn Ile 
            340                 345                 350         


Trp His Val Gln Trp Asn Lys Gly Met Leu Ser Gln Tyr Glu Leu Lys 
        355                 360                 365             


Asp Cys Ser Leu Gly Phe Ser Trp Asn Asp Pro Ala Lys Tyr Leu Arg 
    370                 375                 380                 


Lys Tyr Leu Lys Glu Phe Thr Gln Leu Leu Thr Phe Val Asp Cys Tyr 
385                 390                 395                 400 


Met Trp Ile Thr Phe Cys Gly Pro Asp Ala Asn Asp Asp Thr Pro Asp 
                405                 410                 415     


Phe Arg Lys Cys Tyr Ile Glu Asp His Ser Phe Arg Phe Ser Gln Thr 
            420                 425                 430         


Met Asn Asp Ser Glu Glu Thr Asn Thr Asn Tyr Leu His Tyr Cys His 
        435                 440                 445             


Phe His Trp Thr Trp Ala Gln Gln Thr Thr Val Pro Arg Pro Gly Met 
    450                 455                 460                 


Pro Cys Gln His His Asn Thr His Gly Leu Asn Asp Arg Gln Ala Phe 
465                 470                 475                 480 


Asp Asp Phe Val 
                


<210> 52
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Ser Ser Thr Pro Tyr Leu Tyr Tyr Gly Thr Ser Ser Val Ser Tyr Gln 
1               5                   10                  15      


Phe Pro Met Val Pro Gly Gly Asp Arg 
            20                  25  


<210> 53
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Glu Met Ala Gly Lys Ile Asp Leu Leu Arg Asp Ser Tyr Ile Phe Gln 
1               5                   10                  15      


Leu Phe Trp Arg Glu Ala Ala Glu Pro 
            20                  25  


<210> 54
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Ala Leu Lys Gln Arg Thr Trp Gln Ala Leu Ala His Lys Tyr Asn Ser 
1               5                   10                  15      


Gln Pro Ser Val Ser Leu Arg Asp Phe 
            20                  25  


<210> 55
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Val Ser Ser His Ser Ser Gln Ala Thr Lys Asp Ser Ala Val Gly Leu 
1               5                   10                  15      


Lys Tyr Ser Ala Ser Thr Pro Val Arg 
            20                  25  


<210> 56
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Lys Glu Ala Ile Asp Ala Trp Ala Pro Tyr Leu Pro Glu Tyr Ile Asp 
1               5                   10                  15      


His Val Ile Ser Pro Gly Val Thr Ser 
            20                  25  


<210> 57
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Ser Pro Val Ile Thr Ala Pro Pro Ser Ser Pro Val Phe Asp Thr Ser 
1               5                   10                  15      


Asp Ile Arg Lys Glu Pro Met Asn Ile 
            20                  25  


<210> 58
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Pro Ala Glu Val Ala Glu Gln Tyr Ser Glu Lys Leu Val Tyr Met Pro 
1               5                   10                  15      


His Thr Phe Phe Ile Gly Asp His Ala 
            20                  25  


<210> 59
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Met Ala Asp Leu Asp Lys Leu Asn Ile His Ser Ile Ile Gln Arg Leu 
1               5                   10                  15      


Leu Glu Val Arg Gly Ser 
            20          


<210> 60
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Ala Ala Ala Tyr Asn Glu Lys Ser Gly Arg Ile Thr Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Gln Lys Val Phe Ala Gln Ile 
            20                  25  


<210> 61
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Lys Ile Glu Glu Val Arg Asp Ala Met Glu Asn Glu Ile Arg Thr Gln 
1               5                   10                  15      


Leu Arg Arg Gln Ala Ala Ala His Thr 
            20                  25  


<210> 62
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Asp Arg Gly His Tyr Val Leu Cys Asp Phe Gly Ser Thr Thr Asn Lys 
1               5                   10                  15      


Phe Gln Asn Pro Gln Thr Glu Gly Val 
            20                  25  


<210> 63
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Gln Val Asp Asn Arg Lys Ala Glu Ala Glu Glu Ala Ile Lys Arg Leu 
1               5                   10                  15      


Ser Tyr Ile Ser Gln Lys Val Ser Asp 
            20                  25  


<210> 64
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Cys Leu Ser Asp Ala Gly Val Arg Lys Met Thr Ala Ala Val Arg Val 
1               5                   10                  15      


Met Lys Arg Gly Leu Glu Asn Leu Thr 
            20                  25  


<210> 65
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 65
Leu Pro Pro Arg Ser Leu Pro Ser Asp Pro Phe Ser Gln Val Pro Ala 
1               5                   10                  15      


Ser Pro Gln Ser Gln Ser Ser Ser Gln 
            20                  25  


<210> 66
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 66
Glu Leu Val Leu Glu Asp Leu Gln Asp Gly Asp Val Lys Met Gly Gly 
1               5                   10                  15      


Ser Phe Arg Gly Ala Phe Ser Asn Ser 
            20                  25  


<210> 67
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 67
Val Thr Met Asp Gly Val Arg Glu Glu Asp Leu Ala Ser Phe Ser Leu 
1               5                   10                  15      


Arg Lys Arg Trp Glu Ser Glu Pro His 
            20                  25  


<210> 68
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Ile Val Gly Val Met Phe Phe Glu Arg Ala Phe Asp Glu Gly Ala Asp 
1               5                   10                  15      


Ala Ile Tyr Asp His Ile Asn Glu Gly 
            20                  25  


<210> 69
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Thr Val Thr Pro Thr Pro Thr Pro Thr Gly Thr Gln Ser Pro Thr Pro 
1               5                   10                  15      


Thr Pro Ile Thr Thr Thr Thr Thr Val 
            20                  25  


<210> 70
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Gln Glu Glu Met Pro Pro Arg Pro Cys Gly Gly His Thr Ser Ser Ser 
1               5                   10                  15      


Leu Pro Lys Ser His Leu Glu Pro Ser 
            20                  25  


<210> 71
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 71
Pro Asn Ile Gln Ala Val Leu Leu Pro Lys Lys Thr Asp Ser His His 
1               5                   10                  15      


Lys Ala Lys Gly Lys 
            20      


<210> 72
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 72
Tyr Glu Met Phe Asn Asp Lys Ser Phe Gln Arg Ala Pro Asp Asp Lys 
1               5                   10                  15      


Met Phe 
        


<210> 73
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (6)..(6)
<223> Selenocysteine 

<220>
<221> MOD_RES
<222> (7)..(8)
<223> Pyrrolysine 

<400> 73
Phe Glu Gly Arg Lys Xaa Xaa Xaa Ile 
1               5                   


<210> 74
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Leu or Ile

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Pyrrolysine 

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Leu or Ile

<220>
<221> MOD_RES
<222> (8)..(8)
<223> Pyrrolysine 

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Leu or Ile

<220>
<221> MOD_RES
<222> (14)..(14)
<223> Pyrrolysine 

<400> 74
Pro Xaa Phe Ile Xaa Glu Xaa Xaa Ile Xaa Gly Glu Ile Xaa 
1               5                   10                  


<210> 75
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 75
Ser Ile Asn Phe Glu Lys Leu Ala Ala Tyr Leu Leu Leu Leu Leu Val 
1               5                   10                  15      


Val Val Val 
            


<210> 76
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 76
Leu Leu Leu Leu Leu Val Val Val Val Ala Ala Tyr Ser Ile Asn Phe 
1               5                   10                  15      


Glu Lys Leu 
            


