                         SEQUENCE LISTING

<110>  UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF 
       HIGHER EDUCATION
 
<120>  COMPOSITIONS AND METHODS FOR ADMINISTERING A YAP1/WWRT1 
       INHIBITING COMPOSITION AND A GLS1 INHIBITING COMPOSITIONSION

<130>  10504-023WO1

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asn Pro Ala Ser Ala Pro Pro Pro Leu Pro Pro Pro Gly Gln Gln 
1               5                   10                  15      


Val Ile His Val Thr Gln Asp Leu Asp Thr Asp Leu Glu Ala Leu Phe 
            20                  25                  30          


Asn Ser Val Met Asn Pro Lys Pro Ser Ser Trp Arg Lys Lys Ile Leu 
        35                  40                  45              


Pro Glu Ser Phe Phe Lys Glu Pro Asp Ser Gly Ser His Ser Arg Gln 
    50                  55                  60                  


Ser Ser Thr Asp Ser Ser Gly Gly His Pro Gly Pro Arg Leu Ala Gly 
65                  70                  75                  80  


Gly Ala Gln His Val Arg Ser His Ser Ser Pro Ala Ser Leu Gln Leu 
                85                  90                  95      


Gly Thr Gly Ala Gly Ala Ala Gly Ser Pro Ala Gln Gln His Ala His 
            100                 105                 110         


Leu Arg Gln Gln Ser Tyr Asp Val Thr Asp Glu Leu Pro Leu Pro Pro 
        115                 120                 125             


Gly Trp Glu Met Thr Phe Thr Ala Thr Gly Gln Arg Tyr Phe Leu Asn 
    130                 135                 140                 


His Ile Glu Lys Ile Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Asn 
145                 150                 155                 160 


Gln Pro Leu Asn His Met Asn Leu His Pro Ala Val Ser Ser Thr Pro 
                165                 170                 175     


Val Pro Gln Arg Ser Met Ala Val Ser Gln Pro Asn Leu Val Met Asn 
            180                 185                 190         


His Gln His Gln Gln Gln Met Ala Pro Ser Thr Leu Ser Gln Gln Asn 
        195                 200                 205             


His Pro Thr Gln Asn Pro Pro Ala Gly Leu Met Ser Met Pro Asn Ala 
    210                 215                 220                 


Leu Thr Thr Gln Gln Gln Gln Gln Gln Lys Leu Arg Leu Gln Arg Ile 
225                 230                 235                 240 


Gln Met Glu Arg Glu Arg Ile Arg Met Arg Gln Glu Glu Leu Met Arg 
                245                 250                 255     


Gln Glu Ala Ala Leu Cys Arg Gln Leu Pro Met Glu Ala Glu Thr Leu 
            260                 265                 270         


Ala Pro Val Gln Ala Ala Val Asn Pro Pro Thr Met Thr Pro Asp Met 
        275                 280                 285             


Arg Ser Ile Thr Asn Asn Ser Ser Asp Pro Phe Leu Asn Gly Gly Pro 
    290                 295                 300                 


Tyr His Ser Arg Glu Gln Ser Thr Asp Ser Gly Leu Gly Leu Gly Cys 
305                 310                 315                 320 


Tyr Ser Val Pro Thr Thr Pro Glu Asp Phe Leu Ser Asn Val Asp Glu 
                325                 330                 335     


Met Asp Thr Gly Glu Asn Ala Gly Gln Thr Pro Met Asn Ile Asn Pro 
            340                 345                 350         


Gln Gln Thr Arg Phe Pro Asp Phe Leu Asp Cys Leu Pro Gly Thr Asn 
        355                 360                 365             


Val Asp Leu Gly Thr Leu Glu Ser Glu Asp Leu Ile Pro Leu Phe Asn 
    370                 375                 380                 


Asp Val Glu Ser Ala Leu Asn Lys Ser Glu Pro Phe Leu Thr Trp Leu 
385                 390                 395                 400 


<210>  2
<211>  500
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Asp Pro Gly Gln Gln Pro Pro Pro Gln Pro Ala Pro Gln Gly Gln 
1               5                   10                  15      


Gly Gln Pro Pro Ser Gln Pro Pro Gln Gly Gln Gly Pro Pro Ser Gly 
            20                  25                  30          


Pro Gly Gln Pro Ala Pro Ala Ala Thr Gln Ala Ala Pro Gln Ala Pro 
        35                  40                  45              


Pro Ala Gly His Gln Ile Val His Val Arg Gly Asp Ser Glu Thr Asp 
    50                  55                  60                  


Leu Glu Ala Leu Phe Asn Ala Val Met Asn Pro Lys Thr Ala Asn Val 
65                  70                  75                  80  


Pro Gln Thr Val Pro Met Arg Leu Arg Lys Leu Pro Asp Ser Phe Phe 
                85                  90                  95      


Lys Pro Pro Glu Pro Lys Ser His Ser Arg Gln Ala Ser Thr Asp Ala 
            100                 105                 110         


Gly Thr Ala Gly Ala Leu Thr Pro Gln His Val Arg Ala His Ser Ser 
        115                 120                 125             


Pro Ala Ser Leu Gln Leu Gly Ala Val Ser Pro Gly Thr Leu Thr Pro 
    130                 135                 140                 


Thr Gly Val Val Ser Gly Pro Ala Ala Thr Pro Thr Ala Gln His Leu 
145                 150                 155                 160 


Arg Gln Ser Ser Phe Glu Ile Pro Asp Asp Val Pro Leu Pro Ala Gly 
                165                 170                 175     


Trp Glu Met Ala Lys Thr Ser Ser Gly Gln Arg Tyr Phe Leu Asn His 
            180                 185                 190         


Ile Asp Gln Thr Thr Thr Trp Gln Asp Pro Arg Lys Ala Met Leu Ser 
        195                 200                 205             


Gln Met Asn Val Thr Ala Pro Thr Ser Pro Pro Val Gln Gln Asn Met 
    210                 215                 220                 


Met Asn Ser Ala Ser Gly Pro Leu Pro Asp Gly Trp Glu Gln Ala Met 
225                 230                 235                 240 


Thr Gln Asp Gly Glu Ile Tyr Tyr Ile Asn His Lys Asn Lys Thr Thr 
                245                 250                 255     


Ser Trp Leu Asp Pro Arg Leu Asp Pro Arg Phe Ala Met Asn Gln Arg 
            260                 265                 270         


Ile Ser Gln Ser Ala Pro Val Lys Gln Pro Pro Pro Leu Ala Pro Gln 
        275                 280                 285             


Ser Pro Gln Gly Gly Val Met Gly Gly Ser Asn Ser Asn Gln Gln Gln 
    290                 295                 300                 


Gln Met Arg Leu Gln Gln Leu Gln Met Glu Lys Glu Arg Leu Arg Leu 
305                 310                 315                 320 


Lys Gln Gln Glu Leu Leu Arg Gln Ala Met Arg Asn Ile Asn Pro Ser 
                325                 330                 335     


Thr Ala Asn Ser Pro Lys Cys Gln Glu Leu Ala Leu Arg Ser Gln Leu 
            340                 345                 350         


Pro Thr Leu Glu Gln Asp Gly Gly Thr Gln Asn Pro Val Ser Ser Pro 
        355                 360                 365             


Gly Met Ser Gln Glu Leu Arg Thr Met Thr Thr Asn Ser Ser Asp Pro 
    370                 375                 380                 


Phe Leu Asn Ser Gly Thr Tyr His Ser Arg Asp Glu Ser Thr Asp Ser 
385                 390                 395                 400 


Gly Leu Ser Met Ser Ser Tyr Ser Val Pro Arg Thr Pro Asp Asp Phe 
                405                 410                 415     


Leu Asn Ser Val Asp Glu Met Asp Thr Gly Asp Thr Ile Asn Gln Ser 
            420                 425                 430         


Thr Leu Pro Ser Gln Gln Asn Arg Phe Pro Asp Tyr Leu Glu Ala Ile 
        435                 440                 445             


Pro Gly Thr Asn Val Asp Leu Gly Thr Leu Glu Gly Asp Gly Met Asn 
    450                 455                 460                 


Ile Glu Gly Glu Glu Leu Met Pro Ser Leu Gln Glu Ala Leu Ser Ser 
465                 470                 475                 480 


Asp Ile Leu Asn Asp Met Glu Ser Val Leu Ala Ala Thr Lys Leu Asp 
                485                 490                 495     


Lys Glu Ser Phe 
            500 


<210>  3
<211>  669
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Met Arg Leu Arg Gly Ser Gly Met Leu Arg Asp Leu Leu Leu Arg 
1               5                   10                  15      


Ser Pro Ala Gly Val Ser Ala Thr Leu Arg Arg Ala Gln Pro Leu Val 
            20                  25                  30          


Thr Leu Cys Arg Arg Pro Arg Gly Gly Gly Arg Pro Ala Ala Gly Pro 
        35                  40                  45              


Ala Ala Ala Ala Arg Leu His Pro Trp Trp Gly Gly Gly Gly Trp Pro 
    50                  55                  60                  


Ala Glu Pro Leu Ala Arg Gly Leu Ser Ser Ser Pro Ser Glu Ile Leu 
65                  70                  75                  80  


Gln Glu Leu Gly Lys Gly Ser Thr His Pro Gln Pro Gly Val Ser Pro 
                85                  90                  95      


Pro Ala Ala Pro Ala Ala Pro Gly Pro Lys Asp Gly Pro Gly Glu Thr 
            100                 105                 110         


Asp Ala Phe Gly Asn Ser Glu Gly Lys Glu Leu Val Ala Ser Gly Glu 
        115                 120                 125             


Asn Lys Ile Lys Gln Gly Leu Leu Pro Ser Leu Glu Asp Leu Leu Phe 
    130                 135                 140                 


Tyr Thr Ile Ala Glu Gly Gln Glu Lys Ile Pro Val His Lys Phe Ile 
145                 150                 155                 160 


Thr Ala Leu Lys Ser Thr Gly Leu Arg Thr Ser Asp Pro Arg Leu Lys 
                165                 170                 175     


Glu Cys Met Asp Met Leu Arg Leu Thr Leu Gln Thr Thr Ser Asp Gly 
            180                 185                 190         


Val Met Leu Asp Lys Asp Leu Phe Lys Lys Cys Val Gln Ser Asn Ile 
        195                 200                 205             


Val Leu Leu Thr Gln Ala Phe Arg Arg Lys Phe Val Ile Pro Asp Phe 
    210                 215                 220                 


Met Ser Phe Thr Ser His Ile Asp Glu Leu Tyr Glu Ser Ala Lys Lys 
225                 230                 235                 240 


Gln Ser Gly Gly Lys Val Ala Asp Tyr Ile Pro Gln Leu Ala Lys Phe 
                245                 250                 255     


Ser Pro Asp Leu Trp Gly Val Ser Val Cys Thr Val Asp Gly Gln Arg 
            260                 265                 270         


His Ser Thr Gly Asp Thr Lys Val Pro Phe Cys Leu Gln Ser Cys Val 
        275                 280                 285             


Lys Pro Leu Lys Tyr Ala Ile Ala Val Asn Asp Leu Gly Thr Glu Tyr 
    290                 295                 300                 


Val His Arg Tyr Val Gly Lys Glu Pro Ser Gly Leu Arg Phe Asn Lys 
305                 310                 315                 320 


Leu Phe Leu Asn Glu Asp Asp Lys Pro His Asn Pro Met Val Asn Ala 
                325                 330                 335     


Gly Ala Ile Val Val Thr Ser Leu Ile Lys Gln Gly Val Asn Asn Ala 
            340                 345                 350         


Glu Lys Phe Asp Tyr Val Met Gln Phe Leu Asn Lys Met Ala Gly Asn 
        355                 360                 365             


Glu Tyr Val Gly Phe Ser Asn Ala Thr Phe Gln Ser Glu Arg Glu Ser 
    370                 375                 380                 


Gly Asp Arg Asn Phe Ala Ile Gly Tyr Tyr Leu Lys Glu Lys Lys Cys 
385                 390                 395                 400 


Phe Pro Glu Gly Thr Asp Met Val Gly Ile Leu Asp Phe Tyr Phe Gln 
                405                 410                 415     


Leu Cys Ser Ile Glu Val Thr Cys Glu Ser Ala Ser Val Met Ala Ala 
            420                 425                 430         


Thr Leu Ala Asn Gly Gly Phe Cys Pro Ile Thr Gly Glu Arg Val Leu 
        435                 440                 445             


Ser Pro Glu Ala Val Arg Asn Thr Leu Ser Leu Met His Ser Cys Gly 
    450                 455                 460                 


Met Tyr Asp Phe Ser Gly Gln Phe Ala Phe His Val Gly Leu Pro Ala 
465                 470                 475                 480 


Lys Ser Gly Val Ala Gly Gly Ile Leu Leu Val Val Pro Asn Val Met 
                485                 490                 495     


Gly Met Met Cys Trp Ser Pro Pro Leu Asp Lys Met Gly Asn Ser Val 
            500                 505                 510         


Lys Gly Ile His Phe Cys His Asp Leu Val Ser Leu Cys Asn Phe His 
        515                 520                 525             


Asn Tyr Asp Asn Leu Arg His Phe Ala Lys Lys Leu Asp Pro Arg Arg 
    530                 535                 540                 


Glu Gly Gly Asp Gln Arg Val Lys Ser Val Ile Asn Leu Leu Phe Ala 
545                 550                 555                 560 


Ala Tyr Thr Gly Asp Val Ser Ala Leu Arg Arg Phe Ala Leu Ser Ala 
                565                 570                 575     


Met Asp Met Glu Gln Arg Asp Tyr Asp Ser Arg Thr Ala Leu His Val 
            580                 585                 590         


Ala Ala Ala Glu Gly His Val Glu Val Val Lys Phe Leu Leu Glu Ala 
        595                 600                 605             


Cys Lys Val Asn Pro Phe Pro Lys Asp Arg Trp Asn Asn Thr Pro Met 
    610                 615                 620                 


Asp Glu Ala Leu His Phe Gly His His Asp Val Phe Lys Ile Leu Gln 
625                 630                 635                 640 


Glu Tyr Gln Val Gln Tyr Thr Pro Gln Gly Asp Ser Asp Asn Gly Lys 
                645                 650                 655     


Glu Asn Gln Thr Val His Lys Asn Leu Asp Gly Leu Leu 
            660                 665                 


<210>  4
<211>  598
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Met Arg Leu Arg Gly Ser Gly Met Leu Arg Asp Leu Leu Leu Arg 
1               5                   10                  15      


Ser Pro Ala Gly Val Ser Ala Thr Leu Arg Arg Ala Gln Pro Leu Val 
            20                  25                  30          


Thr Leu Cys Arg Arg Pro Arg Gly Gly Gly Arg Pro Ala Ala Gly Pro 
        35                  40                  45              


Ala Ala Ala Ala Arg Leu His Pro Trp Trp Gly Gly Gly Gly Trp Pro 
    50                  55                  60                  


Ala Glu Pro Leu Ala Arg Gly Leu Ser Ser Ser Pro Ser Glu Ile Leu 
65                  70                  75                  80  


Gln Glu Leu Gly Lys Gly Ser Thr His Pro Gln Pro Gly Val Ser Pro 
                85                  90                  95      


Pro Ala Ala Pro Ala Ala Pro Gly Pro Lys Asp Gly Pro Gly Glu Thr 
            100                 105                 110         


Asp Ala Phe Gly Asn Ser Glu Gly Lys Glu Leu Val Ala Ser Gly Glu 
        115                 120                 125             


Asn Lys Ile Lys Gln Gly Leu Leu Pro Ser Leu Glu Asp Leu Leu Phe 
    130                 135                 140                 


Tyr Thr Ile Ala Glu Gly Gln Glu Lys Ile Pro Val His Lys Phe Ile 
145                 150                 155                 160 


Thr Ala Leu Lys Ser Thr Gly Leu Arg Thr Ser Asp Pro Arg Leu Lys 
                165                 170                 175     


Glu Cys Met Asp Met Leu Arg Leu Thr Leu Gln Thr Thr Ser Asp Gly 
            180                 185                 190         


Val Met Leu Asp Lys Asp Leu Phe Lys Lys Cys Val Gln Ser Asn Ile 
        195                 200                 205             


Val Leu Leu Thr Gln Ala Phe Arg Arg Lys Phe Val Ile Pro Asp Phe 
    210                 215                 220                 


Met Ser Phe Thr Ser His Ile Asp Glu Leu Tyr Glu Ser Ala Lys Lys 
225                 230                 235                 240 


Gln Ser Gly Gly Lys Val Ala Asp Tyr Ile Pro Gln Leu Ala Lys Phe 
                245                 250                 255     


Ser Pro Asp Leu Trp Gly Val Ser Val Cys Thr Val Asp Gly Gln Arg 
            260                 265                 270         


His Ser Thr Gly Asp Thr Lys Val Pro Phe Cys Leu Gln Ser Cys Val 
        275                 280                 285             


Lys Pro Leu Lys Tyr Ala Ile Ala Val Asn Asp Leu Gly Thr Glu Tyr 
    290                 295                 300                 


Val His Arg Tyr Val Gly Lys Glu Pro Ser Gly Leu Arg Phe Asn Lys 
305                 310                 315                 320 


Leu Phe Leu Asn Glu Asp Asp Lys Pro His Asn Pro Met Val Asn Ala 
                325                 330                 335     


Gly Ala Ile Val Val Thr Ser Leu Ile Lys Gln Gly Val Asn Asn Ala 
            340                 345                 350         


Glu Lys Phe Asp Tyr Val Met Gln Phe Leu Asn Lys Met Ala Gly Asn 
        355                 360                 365             


Glu Tyr Val Gly Phe Ser Asn Ala Thr Phe Gln Ser Glu Arg Glu Ser 
    370                 375                 380                 


Gly Asp Arg Asn Phe Ala Ile Gly Tyr Tyr Leu Lys Glu Lys Lys Cys 
385                 390                 395                 400 


Phe Pro Glu Gly Thr Asp Met Val Gly Ile Leu Asp Phe Tyr Phe Gln 
                405                 410                 415     


Leu Cys Ser Ile Glu Val Thr Cys Glu Ser Ala Ser Val Met Ala Ala 
            420                 425                 430         


Thr Leu Ala Asn Gly Gly Phe Cys Pro Ile Thr Gly Glu Arg Val Leu 
        435                 440                 445             


Ser Pro Glu Ala Val Arg Asn Thr Leu Ser Leu Met His Ser Cys Gly 
    450                 455                 460                 


Met Tyr Asp Phe Ser Gly Gln Phe Ala Phe His Val Gly Leu Pro Ala 
465                 470                 475                 480 


Lys Ser Gly Val Ala Gly Gly Ile Leu Leu Val Val Pro Asn Val Met 
                485                 490                 495     


Gly Met Met Cys Trp Ser Pro Pro Leu Asp Lys Met Gly Asn Ser Val 
            500                 505                 510         


Lys Gly Ile His Phe Cys His Asp Leu Val Ser Leu Cys Asn Phe His 
        515                 520                 525             


Asn Tyr Asp Asn Leu Arg His Phe Ala Lys Lys Leu Asp Pro Arg Arg 
    530                 535                 540                 


Glu Gly Gly Asp Gln Arg His Ser Phe Gly Pro Leu Asp Tyr Glu Ser 
545                 550                 555                 560 


Leu Gln Gln Glu Leu Ala Leu Lys Glu Thr Val Trp Lys Lys Val Ser 
                565                 570                 575     


Pro Glu Ser Asn Glu Asp Ile Ser Thr Thr Val Val Tyr Arg Met Glu 
            580                 585                 590         


Ser Leu Gly Glu Lys Ser 
        595             


<210>  5
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Ser Val Asp Asp His Phe Ala Lys Ser Leu Gly Asp Thr Trp Leu Gln 
1               5                   10                  15      


Ile Gly Gly Ser Gly Asn Pro Lys Thr Ala Asn Val Pro Gln Thr Val 
            20                  25                  30          


Pro Met Arg Leu Arg Lys Leu Pro Asp Ser Phe Phe Lys Pro Pro Glu 
        35                  40                  45              


<210>  6
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct; The first instance of Xaa = F(3-Cl) which is
       a 3-chloro-phenylalanine; the second instance of Xaa = Nle which 
       is norleucine


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  6

Pro Gln Thr Val Pro Xaa Ala Ala Arg Leu Arg Lys Xaa Ala Asx Pro 
1               5                   10                  15      


Ala Ser Phe Phe Lys Pro Pro Glu 
            20                  


