                         SEQUENCE LISTING

<110>  Yissum Research Development Company of the Hebrew 
       University of Jerusalem Ltd.
       University of Rijeka Faculty of Medicine
 
<120>  IMMUNOTOXINS FOR TREATING CANCER

<130>  RJK/002 PCT

<150>  US 62/590656
<151>  2017-11-27

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  381
<212>  DNA
<213>  Mus musculus

<400>  1
gaggtccagc tgcagcagcc tggggctgag ctggtaaagc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggcta cagtttcacc agctactgga tgcactgggt gaaacagagg      120

cctggacgag gccttgaggg gattggaata attcatccta atagtggtag tactatctac      180

aatgagaagt tcaagaccaa ggccacactg actgtagata aatcctccac cacagcctac      240

ttgcaactca gcagcctgac atctgaggac tctgcggtct attattgtgg aagagaaggt      300

tacgtttact atgctatgga ctactggggt caaggaacct cagtcaccgt ctcctcagcc      360

aaaacgacac ccccaaagct t                                                381


<210>  2
<211>  127
<212>  PRT
<213>  Mus musculus

<400>  2

Glu Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Gly Ile 
        35                  40                  45              


Gly Ile Ile His Pro Asn Ser Gly Ser Thr Ile Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Glu Gly Tyr Val Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Lys Leu 
        115                 120                 125         


<210>  3
<211>  364
<212>  DNA
<213>  Mus musculus

<400>  3
gacattgtga tgacccagtc tccatcctcc ctggctgtgt cagttggaga gaaggttact       60

atgaactgca agtccagtca gagcctttta tatagtggcg atcaaaggaa ctatttggcc      120

tggtaccagc agaaacctgg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgacggctga agacctggca gtttattact gtcagcaata ttataactat      300

cctcggacgt tcggtggagg caccaacctg gagatcaaac gggctgatgc tgcaccaact      360

gtat                                                                   364


<210>  4
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Gly Asp Gln Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Thr Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Arg Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile 
            100                 105                 110         


Lys Arg Ala Asp Ala Ala Pro Thr Val Ser 
        115                 120         


<210>  5
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  5

Ser Tyr Trp Met His 
1               5   


<210>  6
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  6

Ile Ile His Pro Asn Ser Gly Ser Thr Ile Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


<210>  7
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  7

Glu Gly Tyr Val Tyr Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  8
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  8

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Gly Asp Gln Arg Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  9
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  9

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  10

Gln Gln Tyr Tyr Asn Tyr Pro Arg Thr 
1               5                   


<210>  11
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  11

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  12
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  12

Ile His Pro Asn Ser Gly Ser Thr 
1               5               


<210>  13
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  13

Gly Arg Glu Gly Tyr Val Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  14
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  14

Gln Ser Leu Leu Tyr Ser Gly Asp Gln Arg Asn Tyr 
1               5                   10          


<210>  15
<211>  4
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X=T or no amino acid

<400>  15

Trp Ala Ser Xaa 
1               


<210>  16
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  16

Gln Gln Tyr Tyr Asn Tyr Pro 
1               5           


<210>  17
<211>  4
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X=M or no amino acid

<400>  17

Ser Tyr Trp Xaa 
1               


<210>  18
<211>  4
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X=T or no amino acid

<400>  18

Xaa Ser Tyr Trp 
1               


<210>  19
<211>  667
<212>  PRT
<213>  Recombinant

<400>  19

Met Gly Ala Asp Asp Val Val Asp Ser Ser Lys Ser Phe Val Met Glu 
1               5                   10                  15      


Asn Phe Ser Ser Tyr His Gly Thr Lys Pro Gly Tyr Val Asp Ser Ile 
            20                  25                  30          


Gln Lys Gly Ile Gln Lys Pro Lys Ser Gly Thr Gln Gly Asn Tyr Asp 
        35                  40                  45              


Asp Asp Trp Lys Gly Phe Tyr Ser Thr Asp Asn Lys Tyr Asp Ala Ala 
    50                  55                  60                  


Gly Tyr Ser Val Asp Asn Glu Asn Pro Leu Ser Gly Lys Ala Gly Gly 
65                  70                  75                  80  


Val Val Lys Val Thr Tyr Pro Gly Leu Thr Lys Val Leu Ala Leu Lys 
                85                  90                  95      


Val Asp Asn Ala Glu Thr Ile Lys Lys Glu Leu Gly Leu Ser Leu Thr 
            100                 105                 110         


Glu Pro Leu Met Glu Gln Val Gly Thr Glu Glu Phe Ile Lys Arg Phe 
        115                 120                 125             


Gly Asp Gly Ala Ser Arg Val Val Leu Ser Leu Pro Phe Ala Glu Gly 
    130                 135                 140                 


Ser Ser Ser Val Glu Tyr Ile Asn Asn Trp Glu Gln Ala Lys Ala Leu 
145                 150                 155                 160 


Ser Val Glu Leu Glu Ile Asn Phe Glu Thr Arg Gly Lys Arg Gly Gln 
                165                 170                 175     


Asp Ala Met Tyr Glu Tyr Met Ala Gln Ala Cys Ala Gly Asn Arg Val 
            180                 185                 190         


Arg Arg Ser Val Gly Ser Ser Leu Ser Cys Ile Asn Leu Asp Trp Asp 
        195                 200                 205             


Val Ile Arg Asp Lys Thr Lys Thr Lys Ile Glu Ser Leu Lys Glu His 
    210                 215                 220                 


Gly Pro Ile Lys Asn Lys Met Ser Glu Ser Pro Asn Lys Thr Val Ser 
225                 230                 235                 240 


Glu Glu Lys Ala Lys Gln Tyr Leu Glu Glu Phe His Gln Thr Ala Leu 
                245                 250                 255     


Glu His Pro Glu Leu Ser Glu Leu Lys Thr Val Thr Gly Thr Asn Pro 
            260                 265                 270         


Val Phe Ala Gly Ala Asn Tyr Ala Ala Trp Ala Val Asn Val Ala Gln 
        275                 280                 285             


Val Ile Asp Ser Glu Thr Ala Asp Asn Leu Glu Lys Thr Thr Ala Ala 
    290                 295                 300                 


Leu Ser Ile Leu Pro Gly Ile Gly Ser Val Met Gly Ile Ala Asp Gly 
305                 310                 315                 320 


Ala Val His His Asn Thr Glu Glu Ile Val Ala Gln Ser Ile Ala Leu 
                325                 330                 335     


Ser Ser Leu Met Val Ala Gln Ala Ile Pro Leu Val Gly Glu Leu Val 
            340                 345                 350         


Asp Ile Gly Phe Ala Ala Tyr Asn Phe Val Glu Ser Ile Ile Asn Leu 
        355                 360                 365             


Phe Gln Val Val His Asn Ser Tyr Asn Arg Pro Ala Tyr Ser Pro Gly 
    370                 375                 380                 


His Lys Thr Gln Pro Ala Ser Gly Gly Gly Gly Ser Met Gln Val Gln 
385                 390                 395                 400 


Leu Lys Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys 
                405                 410                 415     


Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Met His 
            420                 425                 430         


Trp Val Lys Gln Arg Pro Gly Arg Gly Leu Glu Gly Ile Gly Ile Ile 
        435                 440                 445             


His Pro Asn Ser Gly Ser Thr Ile Tyr Asn Glu Lys Phe Lys Thr Lys 
    450                 455                 460                 


Ala Thr Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr Leu Gln Leu 
465                 470                 475                 480 


Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Gly Arg Glu 
                485                 490                 495     


Gly Tyr Val Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
            500                 505                 510         


Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Lys Leu Glu Glu Gly Glu 
        515                 520                 525             


Phe Ser Glu Ala Arg Val Asp Ile Leu Met Thr Gln Ser Pro Ser Ser 
    530                 535                 540                 


Leu Ala Val Ser Val Gly Glu Lys Val Thr Met Asn Cys Lys Ser Ser 
545                 550                 555                 560 


Gln Ser Leu Leu Tyr Ser Gly Asp Gln Arg Asn Tyr Leu Ala Trp Tyr 
                565                 570                 575     


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
            580                 585                 590         


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
        595                 600                 605             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Thr Ala Glu Asp Leu Ala 
    610                 615                 620                 


Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Arg Thr Phe Gly Gly 
625                 630                 635                 640 


Gly Thr Asn Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser 
                645                 650                 655     


Ala Ser Ala Gly Ser His His His His His His 
            660                 665         


<210>  20
<211>  254
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Recombinant

<400>  20

Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser 
1               5                   10                  15      


Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr Trp Met His Trp Val 
            20                  25                  30          


Lys Gln Arg Pro Gly Arg Gly Leu Glu Gly Ile Gly Ile Ile His Pro 
        35                  40                  45              


Asn Ser Gly Ser Thr Ile Tyr Asn Glu Lys Phe Lys Thr Lys Ala Thr 
    50                  55                  60                  


Leu Thr Val Asp Lys Ser Ser Thr Thr Ala Tyr Leu Gln Leu Ser Ser 
65                  70                  75                  80  


Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Gly Arg Glu Gly Tyr 
                85                  90                  95      


Val Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
            100                 105                 110         


Ser Ser Ala Lys Thr Thr Pro Pro Lys Leu Glu Glu Gly Glu Phe Ser 
        115                 120                 125             


Glu Ala Arg Val Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ala 
    130                 135                 140                 


Val Ser Val Gly Glu Lys Val Thr Met Asn Cys Lys Ser Ser Gln Ser 
145                 150                 155                 160 


Leu Leu Tyr Ser Gly Asp Gln Arg Asn Tyr Leu Ala Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
            180                 185                 190         


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Val Thr Ala Glu Asp Leu Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Arg Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Asn Leu Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser 
                245                 250                 


<210>  21
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  21

Gly Tyr Ser Phe Thr Ser Tyr Trp Met His 
1               5                   10  


