                         SEQUENCE LISTING

<110>  Onkimmune Limited
 
<120>  MODIFIED NATURAL KILLER CELLS AND NATURAL KILLER CELL LINES TARGETTING TUMOUR CELLS

<130>  P40376WO

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  2439
<212>  DNA
<213>  Human

<400>  1
atgtggcaac tgctgctgcc tacagctctg ctgcttctgg tgtccgccga tatcgtggtc       60

acacaagaga gcgccctgac cacctctcct ggcgaaacag tgaccctgac ctgcagatct      120

tctacaggcg ccgtgaccac aagcaactac gccaactggg tgcaagagaa gcccgatcac      180

ctgttcacag gcctgatcgg cggcacaaac aatagagcac ctggcgtgcc agccagattc      240

agcggatctc tgatcggaga caaggccgca ctgacaatca caggcgccca gacagaggac      300

gaggccatct acttttgcgc cctgtggtac agcaaccact gggttttcgg cggaggcacc      360

aagctgacag tgctgggatc tgaaggtggc ggaggatctg gcggaggtgg aagcggaggc      420

ggaggttctg aagttcagct gcaacaatct ggcggcggac tggttcaacc tggcggctct      480

atgaagctga gctgtgtggc cagcggcttc accttcagca actactggat gaactgggtc      540

cgacagagcc ccgagaaagg cctggaatgg gttgccgaga tcagactgaa gtccaacaat      600

tacgccacac actacgccga gagcgtgaag ggcagattca ccatcagccg ggacgacagc      660

aagagcagcg tgtacctcca gatgaacaac ctgagagccg aggacaccgg catctactac      720

tgcaccttcg gcaacagctt cgcctattgg ggccagggaa ccaccgtgac cgtgtccagc      780

accttcacct gttttgtcgt gggcagcgac ctgaaggatg cccacctgac atgggaagtc      840

gccggcaaag ttcctaccgg tggcgtggaa gaaggcctgc tggaaagaca cagcaacggc      900

agccagagcc agcacagcag actgacactg cctagaagcc tgtggaatgc cggcaccagc      960

gtgacctgca cactgaatca tcctagcctg cctccacaga gactgatggc cctgagagaa     1020

cctgctgctc aggcccctgt gaagctgtcc ctgaatctgc tcgccagcag cgatcctcct     1080

gaagccgcca atgtgaacca caagcctagc aacaccaagg tggacaagaa ggtggaaccc     1140

aagagctgcg acaagaccca cacctgtcct ccatgtcctg ctccagaact gctcggcgga     1200

ccttccgtgt tcctgtttcc tccaaagcct aaggacaccc tgatgatcag cagaacccct     1260

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggatc ccgaagtgaa gttcaattgg     1320

tacgtggacg gcgtcgaggt gcacaacgcc aagacaaagc ccagagagga acagtacaac     1380

agcacctaca gagtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaaa     1440

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgctc ctatcgagaa aaccatcagc     1500

aaggccaagg gccagcctag agaaccccag gtgtacacac tgcctccaag cagagatgag     1560

ctgaccaaga accaggtgtc cctgacatgc ctggtcaagg gcttctaccc ctccgatatc     1620

gccgtggaat gggagagcaa tggacagccc gagaacaact acaagacaac ccctcctgtg     1680

ctggactccg acggctcatt cttcctgtac agcaaactga ccgtggacaa gtccagatgg     1740

cagcagggca acgtgttctc ctgcagcgtg atgcacgagg ccctgcactt ttgggtgctc     1800

gtggttgttg gcggagtgct ggcctgttac agcctgctgg ttaccgtggc cttcatcatc     1860

ttttgggtcc gaagcaagcg gagccggctg ctgcacagcg actacatgaa catgacccct     1920

agacggcccg gacctaccag aaagcactac cagccttacg ctcctcctag agacttcgcc     1980

gcctacagaa gcagacggga ccaaagactg cctcctgacg ctcacaaacc tccaggcggc     2040

ggaagcttca ggacccctat ccaagaagaa caggctgacg cccacagcac cctggccaag     2100

atccgcgtga agttctccag atccgccgac gctcctgcct atcagcaggg acagaaccag     2160

ctgtacaacg agctgaacct ggggagaaga gaagagtacg acgtgctgga taagcggaga     2220

ggcagagatc ctgagatggg cggaaagccc cagcggagaa agaatcctca agagggcctg     2280

tataatgagc tgcagaaaga caagatggcc gaggcctaca gcgagatcgg aatgaagggc     2340

gagcgcagaa gaggcaaggg acacgatgga ctgtaccagg gactgagcac cgccaccaag     2400

gatacctatg acgccctgca catgcaggct ctgcctcca                            2439


<210>  2
<211>  813
<212>  PRT
<213>  Human

<400>  2

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Asp Ile Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
            20                  25                  30          


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
        35                  40                  45              


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
    50                  55                  60                  


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
                85                  90                  95      


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
            100                 105                 110         


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Ser Glu 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Met Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr Trp 
                165                 170                 175     


Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala 
            180                 185                 190         


Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Glu Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val 
    210                 215                 220                 


Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr Tyr 
225                 230                 235                 240 


Cys Thr Phe Gly Asn Ser Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val 
                245                 250                 255     


Thr Val Ser Ser Thr Phe Thr Cys Phe Val Val Gly Ser Asp Leu Lys 
            260                 265                 270         


Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys Val Pro Thr Gly Gly 
        275                 280                 285             


Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn Gly Ser Gln Ser Gln 
    290                 295                 300                 


His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp Asn Ala Gly Thr Ser 
305                 310                 315                 320 


Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro Pro Gln Arg Leu Met 
                325                 330                 335     


Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val Lys Leu Ser Leu Asn 
            340                 345                 350         


Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala Asn Val Asn His Lys 
        355                 360                 365             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    370                 375                 380                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
385                 390                 395                 400 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                405                 410                 415     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            420                 425                 430         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        435                 440                 445             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    450                 455                 460                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
465                 470                 475                 480 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                485                 490                 495     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            500                 505                 510         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        515                 520                 525             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    530                 535                 540                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
545                 550                 555                 560 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                565                 570                 575     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            580                 585                 590         


Glu Ala Leu His Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        595                 600                 605             


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg 
    610                 615                 620                 


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
625                 630                 635                 640 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
                645                 650                 655     


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Arg Asp Gln Arg Leu Pro Pro 
            660                 665                 670         


Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln 
        675                 680                 685             


Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys 
    690                 695                 700                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
705                 710                 715                 720 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                725                 730                 735     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg 
            740                 745                 750         


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
        755                 760                 765             


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
    770                 775                 780                 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
785                 790                 795                 800 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                805                 810             


<210>  3
<211>  24
<212>  PRT
<213>  Human

<400>  3

Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro 
1               5                   10                  15      


Ala Pro Gly Ser Thr Ala Pro Pro 
            20              