                         SEQUENCE LISTING

<110>  The University of Sydney
 
<120>  Antibacterial compounds and methods of use thereof

<130>  97691WOP00

<150>  AU 2017904754
<151>  2017-11-24

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  302
<212>  PRT
<213>  Escherichia coli

<400>  1

Phe Ala Arg Leu Lys Arg Ser Leu Leu Lys Thr Lys Glu Asn Leu Gly 
1               5                   10                  15      


Ser Gly Phe Ile Ser Leu Phe Arg Gly Lys Lys Ile Asp Asp Asp Leu 
            20                  25                  30          


Phe Glu Glu Leu Glu Glu Gln Leu Leu Ile Ala Asp Val Gly Val Glu 
        35                  40                  45              


Thr Thr Arg Lys Ile Ile Thr Asn Leu Thr Glu Gly Ala Ser Arg Lys 
    50                  55                  60                  


Gln Leu Arg Asp Ala Glu Ala Leu Tyr Gly Leu Leu Lys Glu Glu Met 
65                  70                  75                  80  


Gly Glu Ile Leu Ala Lys Val Asp Glu Pro Leu Asn Val Glu Gly Lys 
                85                  90                  95      


Ala Pro Phe Val Ile Leu Met Val Gly Val Asn Gly Val Gly Lys Thr 
            100                 105                 110         


Thr Thr Ile Gly Lys Leu Ala Arg Gln Phe Glu Gln Gln Gly Lys Ser 
        115                 120                 125             


Val Met Leu Ala Ala Gly Asp Thr Phe Arg Ala Ala Ala Val Glu Gln 
    130                 135                 140                 


Leu Gln Val Trp Gly Gln Arg Asn Asn Ile Pro Val Ile Ala Gln His 
145                 150                 155                 160 


Thr Gly Ala Asp Ser Ala Ser Val Ile Phe Asp Ala Ile Gln Ala Ala 
                165                 170                 175     


Lys Ala Arg Asn Ile Asp Val Leu Ile Ala Asp Thr Ala Gly Arg Leu 
            180                 185                 190         


Gln Asn Lys Ser His Leu Met Glu Glu Leu Lys Lys Ile Val Arg Val 
        195                 200                 205             


Met Lys Lys Leu Asp Val Glu Ala Pro His Glu Val Met Leu Thr Ile 
    210                 215                 220                 


Asp Ala Ser Thr Gly Gln Asn Ala Val Ser Gln Ala Lys Leu Phe His 
225                 230                 235                 240 


Glu Ala Val Gly Leu Thr Gly Ile Thr Leu Thr Lys Leu Asp Gly Thr 
                245                 250                 255     


Ala Lys Gly Gly Val Ile Phe Ser Val Ala Asp Gln Phe Gly Ile Pro 
            260                 265                 270         


Ile Arg Tyr Ile Gly Val Gly Glu Arg Ile Glu Asp Leu Arg Pro Phe 
        275                 280                 285             


Lys Ala Asp Asp Phe Ile Glu Ala Leu Phe Ala Arg Glu Asp 
    290                 295                 300         


<210>  2
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Gln Asn Ser Thr Lys Pro Ser Ala Thr Lys Gly Thr Leu Gly Gly 
1               5                   10                  15      


Met Phe Gly Met Leu Lys Gly Leu Val Gly Ser Lys Ser Leu Ser Arg 
            20                  25                  30          


Glu Asp Met Glu Ser Val Leu Asp Lys Met Arg Asp His Leu Ile Ala 
        35                  40                  45              


Lys Asn Val Ala Ala Asp Ile Ala Val Gln Leu Cys Glu Ser Val Ala 
    50                  55                  60                  


Asn Lys Leu Glu Gly Lys Val Met Gly Thr Phe Ser Thr Val Thr Ser 
65                  70                  75                  80  


Thr Val Lys Gln Ala Leu Gln Glu Ser Leu Val Gln Ile Leu Gln Pro 
                85                  90                  95      


Gln Arg Arg Val Asp Met Leu Arg Asp Ile Met Asp Ala Gln Arg Arg 
            100                 105                 110         


Gln Arg Pro Tyr Val Val Thr Phe Cys Gly Val Asn Gly Val Gly Lys 
        115                 120                 125             


Ser Thr Asn Leu Ala Lys Ile Ser Phe Trp Leu Leu Glu Asn Gly Phe 
    130                 135                 140                 


Ser Val Leu Ile Ala Ala Cys Asp Thr Phe Arg Ala Gly Ala Val Glu 
145                 150                 155                 160 


Gln Leu Arg Thr His Thr Arg Arg Leu Ser Ala Leu His Pro Pro Glu 
                165                 170                 175     


Lys His Gly Gly Arg Thr Met Val Gln Leu Phe Glu Lys Gly Tyr Gly 
            180                 185                 190         


Lys Asp Ala Ala Gly Ile Ala Met Glu Ala Ile Ala Phe Ala Arg Asn 
        195                 200                 205             


Gln Gly Phe Asp Val Val Leu Val Asp Thr Ala Gly Arg Met Gln Asp 
    210                 215                 220                 


Asn Ala Pro Leu Met Thr Ala Leu Ala Lys Leu Ile Thr Val Asn Thr 
225                 230                 235                 240 


Pro Asp Leu Val Leu Phe Val Gly Glu Ala Leu Val Gly Asn Glu Ala 
                245                 250                 255     


Val Asp Gln Leu Val Lys Phe Asn Arg Ala Leu Ala Asp His Ser Met 
            260                 265                 270         


Ala Gln Thr Pro Arg Leu Ile Asp Gly Ile Val Leu Thr Lys Phe Asp 
        275                 280                 285             


Thr Ile Asp Asp Lys Val Gly Ala Ala Ile Ser Met Thr Tyr Ile Thr 
    290                 295                 300                 


Ser Lys Pro Ile Val Phe Val Gly Thr Gly Gln Thr Tyr Cys Asp Leu 
305                 310                 315                 320 


Arg Ser Leu Asn Ala Lys Ala Val Val Ala Ala Leu Met Lys Ala 
                325                 330                 335 


<210>  3
<211>  114
<212>  RNA
<213>  Escherichia coli

<400>  3
gggggcucug uugguucucc cgcaacgcua cucuguuuac caggucaggu ccggaaggaa       60

gcagccaagg cagaugacgc gugugccggg auguagcugg cagggccccc accc            114


<210>  4
<211>  497
<212>  PRT
<213>  Escherichia coli

<400>  4

Met Ala Lys Glu Lys Lys Arg Gly Phe Phe Ser Trp Leu Gly Phe Gly 
1               5                   10                  15      


Gln Lys Glu Gln Thr Pro Glu Lys Glu Thr Glu Val Gln Asn Glu Gln 
            20                  25                  30          


Pro Val Val Glu Glu Ile Val Gln Ala Gln Glu Pro Val Lys Ala Ser 
        35                  40                  45              


Glu Gln Ala Val Glu Glu Gln Pro Gln Ala His Thr Glu Ala Glu Ala 
    50                  55                  60                  


Glu Thr Phe Ala Ala Asp Val Val Glu Val Thr Glu Gln Val Ala Glu 
65                  70                  75                  80  


Ser Glu Lys Ala Gln Pro Glu Ala Glu Val Val Ala Gln Pro Glu Pro 
                85                  90                  95      


Val Val Glu Glu Thr Pro Glu Pro Val Ala Ile Glu Arg Glu Glu Leu 
            100                 105                 110         


Pro Leu Pro Glu Asp Val Asn Ala Glu Ala Val Ser Pro Glu Glu Trp 
        115                 120                 125             


Gln Ala Glu Ala Glu Thr Val Glu Ile Val Glu Ala Ala Glu Glu Glu 
    130                 135                 140                 


Ala Ala Lys Glu Glu Ile Thr Asp Glu Glu Leu Glu Thr Ala Leu Ala 
145                 150                 155                 160 


Ala Glu Ala Ala Glu Glu Ala Val Met Val Val Pro Pro Ala Glu Glu 
                165                 170                 175     


Glu Gln Pro Val Glu Glu Ile Ala Gln Glu Gln Glu Lys Pro Thr Lys 
            180                 185                 190         


Glu Gly Phe Phe Ala Arg Leu Lys Arg Ser Leu Leu Lys Thr Lys Glu 
        195                 200                 205             


Asn Leu Gly Ser Gly Phe Ile Ser Leu Phe Arg Gly Lys Lys Ile Asp 
    210                 215                 220                 


Asp Asp Leu Phe Glu Glu Leu Glu Glu Gln Leu Leu Ile Ala Asp Val 
225                 230                 235                 240 


Gly Val Glu Thr Thr Arg Lys Ile Ile Thr Asn Leu Thr Glu Gly Ala 
                245                 250                 255     


Ser Arg Lys Gln Leu Arg Asp Ala Glu Ala Leu Tyr Gly Leu Leu Lys 
            260                 265                 270         


Glu Glu Met Gly Glu Ile Leu Ala Lys Val Asp Glu Pro Leu Asn Val 
        275                 280                 285             


Glu Gly Lys Ala Pro Phe Val Ile Leu Met Val Gly Val Asn Gly Val 
    290                 295                 300                 


Gly Lys Thr Thr Thr Ile Gly Lys Leu Ala Arg Gln Phe Glu Gln Gln 
305                 310                 315                 320 


Gly Lys Ser Val Met Leu Ala Ala Gly Asp Thr Phe Arg Ala Ala Ala 
                325                 330                 335     


Val Glu Gln Leu Gln Val Trp Gly Gln Arg Asn Asn Ile Pro Val Ile 
            340                 345                 350         


Ala Gln His Thr Gly Ala Asp Ser Ala Ser Val Ile Phe Asp Ala Ile 
        355                 360                 365             


Gln Ala Ala Lys Ala Arg Asn Ile Asp Val Leu Ile Ala Asp Thr Ala 
    370                 375                 380                 


Gly Arg Leu Gln Asn Lys Ser His Leu Met Glu Glu Leu Lys Lys Ile 
385                 390                 395                 400 


Val Arg Val Met Lys Lys Leu Asp Val Glu Ala Pro His Glu Val Met 
                405                 410                 415     


Leu Thr Ile Asp Ala Ser Thr Gly Gln Asn Ala Val Ser Gln Ala Lys 
            420                 425                 430         


Leu Phe His Glu Ala Val Gly Leu Thr Gly Ile Thr Leu Thr Lys Leu 
        435                 440                 445             


Asp Gly Thr Ala Lys Gly Gly Val Ile Phe Ser Val Ala Asp Gln Phe 
    450                 455                 460                 


Gly Ile Pro Ile Arg Tyr Ile Gly Val Gly Glu Arg Ile Glu Asp Leu 
465                 470                 475                 480 


Arg Pro Phe Lys Ala Asp Asp Phe Ile Glu Ala Leu Phe Ala Arg Glu 
                485                 490                 495     


Asp 
    


<210>  5
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Expression and purification tag

<400>  5

Met Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      


Ser Phe Ala Arg Leu Lys Arg Ser Leu Leu Lys Thr Lys Glu Asn Leu 
            20                  25                  30          


Gly Ser Gly Phe Ile Ser Leu Phe Arg Gly Lys Lys Ile Asp Asp Asp 
        35                  40                  45              


Leu Phe Glu Glu Leu Glu Glu Gln Leu Leu Ile Ala Asp Val Gly Val 
    50                  55                  60                  


Glu Thr Thr Arg Lys Ile Ile Thr Asn Leu Thr Glu Gly Ala Ser Arg 
65                  70                  75                  80  


Lys Gln Leu Arg Asp Ala Glu Ala Leu Tyr Gly Leu Leu Lys Glu Glu 
                85                  90                  95      


Met Gly Glu Ile Leu Ala Lys Val Asp Glu Pro Leu Asn Val Glu Gly 
            100                 105                 110         


Lys Ala Pro Phe Val Ile Leu Met Val Gly Val Asn Gly Val Gly Lys 
        115                 120                 125             


Thr Thr Thr Ile Gly Lys Leu Ala Arg Gln Phe Glu Gln Gln Gly Lys 
    130                 135                 140                 


Ser Val Met Leu Ala Ala Gly Asp Thr Phe Arg Ala Ala Ala Val Glu 
145                 150                 155                 160 


Gln Leu Gln Val Trp Gly Gln Arg Asn Asn Ile Pro Val Ile Ala Gln 
                165                 170                 175     


His Thr Gly Ala Asp Ser Ala Ser Val Ile Phe Asp Ala Ile Gln Ala 
            180                 185                 190         


Ala Lys Ala Arg Asn Ile Asp Val Leu Ile Ala Asp Thr Ala Gly Arg 
        195                 200                 205             


Leu Gln Asn Lys Ser His Leu Met Glu Glu Leu Lys Lys Ile Val Arg 
    210                 215                 220                 


Val Met Lys Lys Leu Asp Val Glu Ala Pro His Glu Val Met Leu Thr 
225                 230                 235                 240 


Ile Asp Ala Ser Thr Gly Gln Asn Ala Val Ser Gln Ala Lys Leu Phe 
                245                 250                 255     


His Glu Ala Val Gly Leu Thr Gly Ile Thr Leu Thr Lys Leu Asp Gly 
            260                 265                 270         


Thr Ala Lys Gly Gly Val Ile Phe Ser Val Ala Asp Gln Phe Gly Ile 
        275                 280                 285             


Pro Ile Arg Tyr Ile Gly Val Gly Glu Arg Ile Glu Asp Leu Arg Pro 
    290                 295                 300                 


Phe Lys Ala Asp Asp Phe Ile Glu Ala Leu Phe Ala Arg Glu Asp 
305                 310                 315                 


<210>  6
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Leu Asp Phe Phe Thr Ile Phe Ser Lys Gly Gly Leu Val Leu Trp 
1               5                   10                  15      


Cys Phe Gln Gly Val Ser Asp Ser Cys Thr Gly Pro Val Asn Ala Leu 
            20                  25                  30          


Ile Arg Ser Val Leu Leu Gln Glu Arg Gly Gly Asn Asn Ser Phe Thr 
        35                  40                  45              


His Glu Ala Leu Thr Leu Lys Tyr Lys Leu Asp Asn Gln Phe Glu Leu 
    50                  55                  60                  


Val Phe Val Val Gly Phe Gln Lys Ile Leu Thr Leu Thr Tyr Val Asp 
65                  70                  75                  80  


Lys Leu Ile Asp Asp Val His Arg Leu Phe Arg Asp Lys Tyr Arg Thr 
                85                  90                  95      


Glu Ile Gln Gln Gln Ser Ala Leu Ser Leu Leu Asn Gly Thr Phe Asp 
            100                 105                 110         


Phe Gln Asn Asp Phe Leu Arg Leu Leu Arg Glu Ala Glu Glu Ser Ser 
        115                 120                 125             


Lys Ile Arg Ala Pro Thr Thr Met Lys Lys Phe Glu Asp Ser Glu Lys 
    130                 135                 140                 


Ala Lys Lys Pro Val Arg Ser Met Ile Glu Thr Arg Gly Glu Lys Pro 
145                 150                 155                 160 


Lys Glu Lys Ala Lys Asn Ser Lys Lys Lys Gly Ala Lys Lys Glu Gly 
                165                 170                 175     


Ser Asp Gly Pro Leu Ala Thr Ser Lys Pro Val Pro Ala Glu Lys Ser 
            180                 185                 190         


Gly Leu Pro Val Gly Pro Glu Asn Gly Val Glu Leu Ser Lys Glu Glu 
        195                 200                 205             


Leu Ile Arg Arg Lys Arg Glu Glu Phe Ile Gln Lys His Gly Arg Gly 
    210                 215                 220                 


Met Glu Lys Ser Asn Lys Ser Thr Lys Ser Asp Ala Pro Lys Glu Lys 
225                 230                 235                 240 


Gly Lys Lys Ala Pro Arg Val Trp Glu Leu Gly Gly Cys Ala Asn Lys 
                245                 250                 255     


Glu Val Leu Asp Tyr Ser Thr Pro Thr Thr Asn Gly Thr Pro Glu Ala 
            260                 265                 270         


Ala Leu Ser Glu Asp Ile Asn Leu Ile Arg Gly Thr Gly Ser Gly Gly 
        275                 280                 285             


Gln Leu Gln Asp Leu Asp Cys Ser Ser Ser Asp Asp Glu Gly Ala Ala 
    290                 295                 300                 


Gln Asn Ser Thr Lys Pro Ser Ala Thr Lys Gly Thr Leu Gly Gly Met 
305                 310                 315                 320 


Phe Gly Met Leu Lys Gly Leu Val Gly Ser Lys Ser Leu Ser Arg Glu 
                325                 330                 335     


Asp Met Glu Ser Val Leu Asp Lys Met Arg Asp His Leu Ile Ala Lys 
            340                 345                 350         


Asn Val Ala Ala Asp Ile Ala Val Gln Leu Cys Glu Ser Val Ala Asn 
        355                 360                 365             


Lys Leu Glu Gly Lys Val Met Gly Thr Phe Ser Thr Val Thr Ser Thr 
    370                 375                 380                 


Val Lys Gln Ala Leu Gln Glu Ser Leu Val Gln Ile Leu Gln Pro Gln 
385                 390                 395                 400 


Arg Arg Val Asp Met Leu Arg Asp Ile Met Asp Ala Gln Arg Arg Gln 
                405                 410                 415     


Arg Pro Tyr Val Val Thr Phe Cys Gly Val Asn Gly Val Gly Lys Ser 
            420                 425                 430         


Thr Asn Leu Ala Lys Ile Ser Phe Trp Leu Leu Glu Asn Gly Phe Ser 
        435                 440                 445             


Val Leu Ile Ala Ala Cys Asp Thr Phe Arg Ala Gly Ala Val Glu Gln 
    450                 455                 460                 


Leu Arg Thr His Thr Arg Arg Leu Ser Ala Leu His Pro Pro Glu Lys 
465                 470                 475                 480 


His Gly Gly Arg Thr Met Val Gln Leu Phe Glu Lys Gly Tyr Gly Lys 
                485                 490                 495     


Asp Ala Ala Gly Ile Ala Met Glu Ala Ile Ala Phe Ala Arg Asn Gln 
            500                 505                 510         


Gly Phe Asp Val Val Leu Val Asp Thr Ala Gly Arg Met Gln Asp Asn 
        515                 520                 525             


Ala Pro Leu Met Thr Ala Leu Ala Lys Leu Ile Thr Val Asn Thr Pro 
    530                 535                 540                 


Asp Leu Val Leu Phe Val Gly Glu Ala Leu Val Gly Asn Glu Ala Val 
545                 550                 555                 560 


Asp Gln Leu Val Lys Phe Asn Arg Ala Leu Ala Asp His Ser Met Ala 
                565                 570                 575     


Gln Thr Pro Arg Leu Ile Asp Gly Ile Val Leu Thr Lys Phe Asp Thr 
            580                 585                 590         


Ile Asp Asp Lys Val Gly Ala Ala Ile Ser Met Thr Tyr Ile Thr Ser 
        595                 600                 605             


Lys Pro Ile Val Phe Val Gly Thr Gly Gln Thr Tyr Cys Asp Leu Arg 
    610                 615                 620                 


Ser Leu Asn Ala Lys Ala Val Val Ala Ala Leu Met Lys Ala 
625                 630                 635             


<210>  7
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Expression and purification tag

<400>  7

Met Gly Ser Ser His His His His His His Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      


Ser Ala Gln Asn Ser Thr Lys Pro Ser Ala Thr Lys Gly Thr Leu Gly 
            20                  25                  30          


Gly Met Phe Gly Met Leu Lys Gly Leu Val Gly Ser Lys Ser Leu Ser 
        35                  40                  45              


Arg Glu Asp Met Glu Ser Val Leu Asp Lys Met Arg Asp His Leu Ile 
    50                  55                  60                  


Ala Lys Asn Val Ala Ala Asp Ile Ala Val Gln Leu Cys Glu Ser Val 
65                  70                  75                  80  


Ala Asn Lys Leu Glu Gly Lys Val Met Gly Thr Phe Ser Thr Val Thr 
                85                  90                  95      


Ser Thr Val Lys Gln Ala Leu Gln Glu Ser Leu Val Gln Ile Leu Gln 
            100                 105                 110         


Pro Gln Arg Arg Val Asp Met Leu Arg Asp Ile Met Asp Ala Gln Arg 
        115                 120                 125             


Arg Gln Arg Pro Tyr Val Val Thr Phe Cys Gly Val Asn Gly Val Gly 
    130                 135                 140                 


Lys Ser Thr Asn Leu Ala Lys Ile Ser Phe Trp Leu Leu Glu Asn Gly 
145                 150                 155                 160 


Phe Ser Val Leu Ile Ala Ala Cys Asp Thr Phe Arg Ala Gly Ala Val 
                165                 170                 175     


Glu Gln Leu Arg Thr His Thr Arg Arg Leu Ser Ala Leu His Pro Pro 
            180                 185                 190         


Glu Lys His Gly Gly Arg Thr Met Val Gln Leu Phe Glu Lys Gly Tyr 
        195                 200                 205             


Gly Lys Asp Ala Ala Gly Ile Ala Met Glu Ala Ile Ala Phe Ala Arg 
    210                 215                 220                 


Asn Gln Gly Phe Asp Val Val Leu Val Asp Thr Ala Gly Arg Met Gln 
225                 230                 235                 240 


Asp Asn Ala Pro Leu Met Thr Ala Leu Ala Lys Leu Ile Thr Val Asn 
                245                 250                 255     


Thr Pro Asp Leu Val Leu Phe Val Gly Glu Ala Leu Val Gly Asn Glu 
            260                 265                 270         


Ala Val Asp Gln Leu Val Lys Phe Asn Arg Ala Leu Ala Asp His Ser 
        275                 280                 285             


Met Ala Gln Thr Pro Arg Leu Ile Asp Gly Ile Val Leu Thr Lys Phe 
    290                 295                 300                 


Asp Thr Ile Asp Asp Lys Val Gly Ala Ala Ile Ser Met Thr Tyr Ile 
305                 310                 315                 320 


Thr Ser Lys Pro Ile Val Phe Val Gly Thr Gly Gln Thr Tyr Cys Asp 
                325                 330                 335     


Leu Arg Ser Leu Asn Ala Lys Ala Val Val Ala Ala Leu Met Lys Ala 
            340                 345                 350         


<210>  8
<211>  299
<212>  RNA
<213>  Homo sapiens

<400>  8
gccgggcgcg guggcgcgug ccuguagucc cagcuacucg ggaggcugag gcuggaggau       60

cgcuugaguc caggaguucu gggcuguagu gcgcuaugcc gaucgggugu ccgcacuaag      120

uucggcauca auauggugac cucccgggag cgggggacca ccagguugcc uaaggagggg      180

ugaaccggcc caggucggaa acggagcagg ucaaaacucc cgugcugauc aguaguggga      240

ucgcgccugu gaauagccac ugcacuccag ccugggcaac auagcgagac cccgucucu       299


<210>  9
<211>  283
<212>  PRT
<213>  Escherichia coli

<400>  9

Leu Gly Ser Gly Phe Ile Ser Leu Phe Arg Gly Lys Lys Ile Asp Asp 
1               5                   10                  15      


Asp Leu Phe Glu Glu Leu Glu Glu Gln Leu Leu Ile Ala Asp Val Gly 
            20                  25                  30          


Val Glu Thr Thr Arg Lys Ile Ile Thr Asn Leu Thr Glu Gly Ala Ser 
        35                  40                  45              


Arg Lys Gln Leu Arg Asp Ala Glu Ala Leu Tyr Gly Leu Leu Lys Glu 
    50                  55                  60                  


Glu Met Gly Glu Ile Leu Ala Lys Val Asp Glu Pro Leu Asn Val Glu 
65                  70                  75                  80  


Gly Lys Ala Pro Phe Val Ile Leu Met Val Gly Val Asn Gly Val Gly 
                85                  90                  95      


Lys Thr Thr Thr Ile Gly Lys Leu Ala Arg Gln Phe Glu Gln Gln Gly 
            100                 105                 110         


Lys Ser Val Met Leu Ala Ala Gly Asp Thr Phe Arg Ala Ala Ala Val 
        115                 120                 125             


Glu Gln Leu Gln Val Trp Gly Gln Arg Asn Asn Ile Pro Val Ile Ala 
    130                 135                 140                 


Gln His Thr Gly Ala Asp Ser Ala Ser Val Ile Phe Asp Ala Ile Gln 
145                 150                 155                 160 


Ala Ala Lys Ala Arg Asn Ile Asp Val Leu Ile Ala Asp Thr Ala Gly 
                165                 170                 175     


Arg Leu Gln Asn Lys Ser His Leu Met Glu Glu Leu Lys Lys Ile Val 
            180                 185                 190         


Arg Val Met Lys Lys Leu Asp Val Glu Ala Pro His Glu Val Met Leu 
        195                 200                 205             


Thr Ile Asp Ala Ser Thr Gly Gln Asn Ala Val Ser Gln Ala Lys Leu 
    210                 215                 220                 


Phe His Glu Ala Val Gly Leu Thr Gly Ile Thr Leu Thr Lys Leu Asp 
225                 230                 235                 240 


Gly Thr Ala Lys Gly Gly Val Ile Phe Ser Val Ala Asp Gln Phe Gly 
                245                 250                 255     


Ile Pro Ile Arg Tyr Ile Gly Val Gly Glu Arg Ile Glu Asp Leu Arg 
            260                 265                 270         


Pro Phe Lys Ala Asp Asp Phe Ile Glu Ala Leu 
        275                 280             


<210>  10
<211>  308
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Gly Ser Lys Ser Leu Ser Arg Glu Asp Met Glu Ser Val Leu Asp 
1               5                   10                  15      


Lys Met Arg Asp His Leu Ile Ala Lys Asn Val Ala Ala Asp Ile Ala 
            20                  25                  30          


Val Gln Leu Cys Glu Ser Val Ala Asn Lys Leu Glu Gly Lys Val Met 
        35                  40                  45              


Gly Thr Phe Ser Thr Val Thr Ser Thr Val Lys Gln Ala Leu Gln Glu 
    50                  55                  60                  


Ser Leu Val Gln Ile Leu Gln Pro Gln Arg Arg Val Asp Met Leu Arg 
65                  70                  75                  80  


Asp Ile Met Asp Ala Gln Arg Arg Gln Arg Pro Tyr Val Val Thr Phe 
                85                  90                  95      


Cys Gly Val Asn Gly Val Gly Lys Ser Thr Asn Leu Ala Lys Ile Ser 
            100                 105                 110         


Phe Trp Leu Leu Glu Asn Gly Phe Ser Val Leu Ile Ala Ala Cys Asp 
        115                 120                 125             


Thr Phe Arg Ala Gly Ala Val Glu Gln Leu Arg Thr His Thr Arg Arg 
    130                 135                 140                 


Leu Ser Ala Leu His Pro Pro Glu Lys His Gly Gly Arg Thr Met Val 
145                 150                 155                 160 


Gln Leu Phe Glu Lys Gly Tyr Gly Lys Asp Ala Ala Gly Ile Ala Met 
                165                 170                 175     


Glu Ala Ile Ala Phe Ala Arg Asn Gln Gly Phe Asp Val Val Leu Val 
            180                 185                 190         


Asp Thr Ala Gly Arg Met Gln Asp Asn Ala Pro Leu Met Thr Ala Leu 
        195                 200                 205             


Ala Lys Leu Ile Thr Val Asn Thr Pro Asp Leu Val Leu Phe Val Gly 
    210                 215                 220                 


Glu Ala Leu Val Gly Asn Glu Ala Val Asp Gln Leu Val Lys Phe Asn 
225                 230                 235                 240 


Arg Ala Leu Ala Asp His Ser Met Ala Gln Thr Pro Arg Leu Ile Asp 
                245                 250                 255     


Gly Ile Val Leu Thr Lys Phe Asp Thr Ile Asp Asp Lys Val Gly Ala 
            260                 265                 270         


Ala Ile Ser Met Thr Tyr Ile Thr Ser Lys Pro Ile Val Phe Val Gly 
        275                 280                 285             


Thr Gly Gln Thr Tyr Cys Asp Leu Arg Ser Leu Asn Ala Lys Ala Val 
    290                 295                 300                 


Val Ala Ala Leu 
305             


