                         SEQUENCE LISTING

<110>  The Johns Hopkins University
 
<120>  ANASTASIS BIOSENSOR CASPASE TRACKER

<130>  P15014-02

<150>  62/587,201
<151>  2017-11-16

<160>  45    

<170>  PatentIn version 3.5

<210>  1
<211>  2937
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lyn11-NES-ERT2-DEVD-rtTA-3xFLAG-DEVD-ERT2-NES

<400>  1
ggatgtataa aatcaaaagg gaaagacagc gcgggagcag atagtgctgg tagtgctggt       60

aacctggtgg acctccaaaa gaagctggag gagctggagc tggacgagca gcaggctgga      120

gacatgagag ctgccaacct ttggccaagc ccgctcatga tcaaacgctc taagaagaac      180

agcctggcct tgtccctgac ggccgaccag atggtcagtg ccttgttgga tgctgagccc      240

cccatactct attccgagta tgatcctacc agacccttca gtgaagcttc gatgatgggc      300

ttactgacca acctggcaga cagggagctg gttcacatga tcaactgggc gaagagggtg      360

ccaggctttg tggatttgac cctccatgat caggtccacc ttctagaatg tgcctggcta      420

gagatcctga tgattggtct cgtctggcgc tccatggagc acccagtgaa gctactgttt      480

gctcctaact tgctcttgga caggaaccag ggaaaatgtg tagagggcat ggtggagatc      540

ttcgacatgc tgctggctac atcatctcgg ttccgcatga tgaatctgca gggagaggag      600

tttgtgtgcc tcaaatctat tattttgctt aattctggag tgtacacatt tctgtccagc      660

accctgaagt ctctggaaga gaaggaccat atccaccgag tcctggacaa gatcacagac      720

actttgatcc acctgatggc caaggcaggc ctgaccctgc agcagcagca ccagcggctg      780

gcccagctcc tcctcatcct ctcccacatc aggcacatga gtaacaaagg catggagcat      840

ctgtacagca tgaagtgcaa gaacgtggtg cccctctatg acctgctgct ggaggcggcg      900

gacgcccacc gcctacatgc gcccactagc cgtggagggg catccgtgga ggagacggac      960

caaagccact tggccactgc gggctctact tcatcgcatt ccttgcaaaa gtattacatc     1020

acgggggagg cagagggttt ccctgccaca gctgtcgaca agaggaaggg cgacgaggtg     1080

gacggcgtgg acgagtctag actggacaag agcaaagtca taaacggcgc tctggaatta     1140

ctcaatggag tcggtatcga aggcctgacg acaaggaaac tcgctcaaaa gctgggagtt     1200

gagcagccta ccctgtactg gcacgtgaag aacaagcggg ccctgctcga tgccctgcca     1260

atcgagatgc tggacaggca tcatacccac ttctgccccc tggaaggcga gtcatggcaa     1320

gactttctgc ggaacaacgc caagtcattc cgctgtgctc tcctctcaca tcgcgacggg     1380

gctaaagtgc atctcggcac ccgcccaaca gagaaacagt acgaaaccct ggaaaatcag     1440

ctcgcgttcc tgtgtcagca aggcttctcc ctggagaacg cactgtacgc tctgtccgcc     1500

gtgggccact ttacactggg ctgcgtattg gaggaacagg agcatcaagt agcaaaagag     1560

gaaagagaga cacctaccac cgattctatg cccccacttc tgagacaagc aattgagctg     1620

ttcgaccggc agggagccga acctgccttc cttttcggcc tggaactaat catatgtggc     1680

ctggagaaac agctaaagtg cgaaagcggc gggccggccg acgcccttga cgattttgac     1740

ttagacatgc tcccagccga tgcccttgac gactttgacc ttgatatgct gcctgctgac     1800

gctcttgacg attttgacct tgacatgctc cccggggact acaaagacca tgacggtgat     1860

tataaagatc atgacatcga ttacaaggat gacgatgacg caaaacgcaa aggtgatgaa     1920

gtagatggag tagacgaagc aggggatatg cgcgcagcaa acctctggcc ttcacccctg     1980

atgataaaga ggtcaaagaa aaactctctc gctctgtcac tcaccgcaga tcaaatggtg     2040

tccgcactgc tggacgccga gcctccaata ttgtacagtg aatacgatcc cactcggcct     2100

ttttccgagg cctccatgat ggggctcctc acaaatctcg ccgatcgaga acttgtgcat     2160

atgataaatt gggccaaacg agtccctggt ttcgttgatc ttactctgca cgaccaagta     2220

catctgctgg agtgcgcttg gctggaaatt ctcatgatcg ggctggtatg gaggagcatg     2280

gaacatcccg tcaaactgct cttcgccccc aacctcttgc tcgaccgaaa tcaggggaag     2340

tgcgtggaag ggatggtaga aatatttgat atgctcctgg ccacaagcag cagattcaga     2400

atgatgaacc tccaaggcga agaattcgtt tgtttgaaga gcatcatcct gctcaacagc     2460

ggcgtctata ccttcctctc ctccacgttg aaaagccttg aggaaaaaga tcacatccat     2520

agggtacttg ataaaattac tgataccctc atacacctta tggcaaaagc gggactcaca     2580

cttcaacaac aacatcaaag actcgcacaa ttgttgttga ttttgagcca tataaggcat     2640

atgtcaaata agggaatgga acacctctac tctatgaaat gtaagaatgt cgtcccactg     2700

tacgatcttc tccttgaagc tgcagatgct catcggctcc acgcacctac ctctcggggc     2760

ggcgctagcg ttgaagagac tgatcagtca catctcgcga cagctggaag cacaagcagc     2820

cacagcctcc aaaaatacta tattacaggc gaggccgaag gcttccccgc tacggccgtg     2880

gataatcttg tagatcttca gaaaaaactc gaagaacttg agcttgatga acaacaa        2937


<210>  2
<211>  979
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lyn11-NES-ERT2-DEVD-rtTA-3xFLAG-DEVD-ERT2-NES

<400>  2

Gly Cys Ile Lys Ser Lys Gly Lys Asp Ser Ala Gly Ala Asp Ser Ala 
1               5                   10                  15      


Gly Ser Ala Gly Asn Leu Val Asp Leu Gln Lys Lys Leu Glu Glu Leu 
            20                  25                  30          


Glu Leu Asp Glu Gln Gln Ala Gly Asp Met Arg Ala Ala Asn Leu Trp 
        35                  40                  45              


Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn Ser Leu Ala Leu 
    50                  55                  60                  


Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro 
65                  70                  75                  80  


Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala 
                85                  90                  95      


Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His 
            100                 105                 110         


Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu 
        115                 120                 125             


His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met 
    130                 135                 140                 


Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val Lys Leu Leu Phe 
145                 150                 155                 160 


Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly 
                165                 170                 175     


Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg 
            180                 185                 190         


Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile 
        195                 200                 205             


Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser 
    210                 215                 220                 


Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp Lys Ile Thr Asp 
225                 230                 235                 240 


Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln 
                245                 250                 255     


His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His 
            260                 265                 270         


Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys Cys Lys Asn 
        275                 280                 285             


Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Ala Ala Asp Ala His Arg 
    290                 295                 300                 


Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val Glu Glu Thr Asp 
305                 310                 315                 320 


Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser His Ser Leu Gln 
                325                 330                 335     


Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro Ala Thr Ala Val 
            340                 345                 350         


Asp Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Ser Arg Leu 
        355                 360                 365             


Asp Lys Ser Lys Val Ile Asn Gly Ala Leu Glu Leu Leu Asn Gly Val 
    370                 375                 380                 


Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val 
385                 390                 395                 400 


Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu 
                405                 410                 415     


Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His Thr His Phe Cys 
            420                 425                 430         


Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys 
        435                 440                 445             


Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His 
    450                 455                 460                 


Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln 
465                 470                 475                 480 


Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr 
                485                 490                 495     


Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Glu 
            500                 505                 510         


Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp 
        515                 520                 525             


Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp Arg Gln 
    530                 535                 540                 


Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly 
545                 550                 555                 560 


Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala Asp Ala Leu 
                565                 570                 575     


Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe 
            580                 585                 590         


Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        595                 600                 605             


Met Leu Pro Gly Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His 
    610                 615                 620                 


Asp Ile Asp Tyr Lys Asp Asp Asp Asp Ala Lys Arg Lys Gly Asp Glu 
625                 630                 635                 640 


Val Asp Gly Val Asp Glu Ala Gly Asp Met Arg Ala Ala Asn Leu Trp 
                645                 650                 655     


Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn Ser Leu Ala Leu 
            660                 665                 670         


Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro 
        675                 680                 685             


Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala 
    690                 695                 700                 


Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His 
705                 710                 715                 720 


Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu 
                725                 730                 735     


His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met 
            740                 745                 750         


Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val Lys Leu Leu Phe 
        755                 760                 765             


Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly 
    770                 775                 780                 


Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg 
785                 790                 795                 800 


Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile 
                805                 810                 815     


Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser 
            820                 825                 830         


Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp Lys Ile Thr Asp 
        835                 840                 845             


Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln 
    850                 855                 860                 


His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His 
865                 870                 875                 880 


Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys Cys Lys Asn 
                885                 890                 895     


Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Ala Ala Asp Ala His Arg 
            900                 905                 910         


Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val Glu Glu Thr Asp 
        915                 920                 925             


Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser His Ser Leu Gln 
    930                 935                 940                 


Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro Ala Thr Ala Val 
945                 950                 955                 960 


Asp Asn Leu Val Asp Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp 
                965                 970                 975     


Glu Gln Gln 
            


<210>  3
<211>  2934
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lyn11-Nes-ERT2-DEVD-rtTA-3xFLAG-DEVD-ERT2-Nes minus the gca codon
       at end of 3x flag

<400>  3
ggatgtataa aatcaaaagg gaaagacagc gcgggagcag atagtgctgg tagtgctggt       60

aacctggtgg acctccaaaa gaagctggag gagctggagc tggacgagca gcaggctgga      120

gacatgagag ctgccaacct ttggccaagc ccgctcatga tcaaacgctc taagaagaac      180

agcctggcct tgtccctgac ggccgaccag atggtcagtg ccttgttgga tgctgagccc      240

cccatactct attccgagta tgatcctacc agacccttca gtgaagcttc gatgatgggc      300

ttactgacca acctggcaga cagggagctg gttcacatga tcaactgggc gaagagggtg      360

ccaggctttg tggatttgac cctccatgat caggtccacc ttctagaatg tgcctggcta      420

gagatcctga tgattggtct cgtctggcgc tccatggagc acccagtgaa gctactgttt      480

gctcctaact tgctcttgga caggaaccag ggaaaatgtg tagagggcat ggtggagatc      540

ttcgacatgc tgctggctac atcatctcgg ttccgcatga tgaatctgca gggagaggag      600

tttgtgtgcc tcaaatctat tattttgctt aattctggag tgtacacatt tctgtccagc      660

accctgaagt ctctggaaga gaaggaccat atccaccgag tcctggacaa gatcacagac      720

actttgatcc acctgatggc caaggcaggc ctgaccctgc agcagcagca ccagcggctg      780

gcccagctcc tcctcatcct ctcccacatc aggcacatga gtaacaaagg catggagcat      840

ctgtacagca tgaagtgcaa gaacgtggtg cccctctatg acctgctgct ggaggcggcg      900

gacgcccacc gcctacatgc gcccactagc cgtggagggg catccgtgga ggagacggac      960

caaagccact tggccactgc gggctctact tcatcgcatt ccttgcaaaa gtattacatc     1020

acgggggagg cagagggttt ccctgccaca gctgtcgaca agaggaaggg cgacgaggtg     1080

gacggcgtgg acgagtctag actggacaag agcaaagtca taaacggcgc tctggaatta     1140

ctcaatggag tcggtatcga aggcctgacg acaaggaaac tcgctcaaaa gctgggagtt     1200

gagcagccta ccctgtactg gcacgtgaag aacaagcggg ccctgctcga tgccctgcca     1260

atcgagatgc tggacaggca tcatacccac ttctgccccc tggaaggcga gtcatggcaa     1320

gactttctgc ggaacaacgc caagtcattc cgctgtgctc tcctctcaca tcgcgacggg     1380

gctaaagtgc atctcggcac ccgcccaaca gagaaacagt acgaaaccct ggaaaatcag     1440

ctcgcgttcc tgtgtcagca aggcttctcc ctggagaacg cactgtacgc tctgtccgcc     1500

gtgggccact ttacactggg ctgcgtattg gaggaacagg agcatcaagt agcaaaagag     1560

gaaagagaga cacctaccac cgattctatg cccccacttc tgagacaagc aattgagctg     1620

ttcgaccggc agggagccga acctgccttc cttttcggcc tggaactaat catatgtggc     1680

ctggagaaac agctaaagtg cgaaagcggc gggccggccg acgcccttga cgattttgac     1740

ttagacatgc tcccagccga tgcccttgac gactttgacc ttgatatgct gcctgctgac     1800

gctcttgacg attttgacct tgacatgctc cccggggact acaaagacca tgacggtgat     1860

tataaagatc atgacatcga ttacaaggat gacgatgaca aacgcaaagg tgatgaagta     1920

gatggagtag acgaagcagg ggatatgcgc gcagcaaacc tctggccttc acccctgatg     1980

ataaagaggt caaagaaaaa ctctctcgct ctgtcactca ccgcagatca aatggtgtcc     2040

gcactgctgg acgccgagcc tccaatattg tacagtgaat acgatcccac tcggcctttt     2100

tccgaggcct ccatgatggg gctcctcaca aatctcgccg atcgagaact tgtgcatatg     2160

ataaattggg ccaaacgagt ccctggtttc gttgatctta ctctgcacga ccaagtacat     2220

ctgctggagt gcgcttggct ggaaattctc atgatcgggc tggtatggag gagcatggaa     2280

catcccgtca aactgctctt cgcccccaac ctcttgctcg accgaaatca ggggaagtgc     2340

gtggaaggga tggtagaaat atttgatatg ctcctggcca caagcagcag attcagaatg     2400

atgaacctcc aaggcgaaga attcgtttgt ttgaagagca tcatcctgct caacagcggc     2460

gtctatacct tcctctcctc cacgttgaaa agccttgagg aaaaagatca catccatagg     2520

gtacttgata aaattactga taccctcata caccttatgg caaaagcggg actcacactt     2580

caacaacaac atcaaagact cgcacaattg ttgttgattt tgagccatat aaggcatatg     2640

tcaaataagg gaatggaaca cctctactct atgaaatgta agaatgtcgt cccactgtac     2700

gatcttctcc ttgaagctgc agatgctcat cggctccacg cacctacctc tcggggcggc     2760

gctagcgttg aagagactga tcagtcacat ctcgcgacag ctggaagcac aagcagccac     2820

agcctccaaa aatactatat tacaggcgag gccgaaggct tccccgctac ggccgtggat     2880

aatcttgtag atcttcagaa aaaactcgaa gaacttgagc ttgatgaaca acaa           2934


<210>  4
<211>  978
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lyn11-Nes-ERT2-DEVD-rtTA-3xFLAG-DEVD-ERT2-Nes minues the gca 
       codon at end of 3x flag

<400>  4

Gly Cys Ile Lys Ser Lys Gly Lys Asp Ser Ala Gly Ala Asp Ser Ala 
1               5                   10                  15      


Gly Ser Ala Gly Asn Leu Val Asp Leu Gln Lys Lys Leu Glu Glu Leu 
            20                  25                  30          


Glu Leu Asp Glu Gln Gln Ala Gly Asp Met Arg Ala Ala Asn Leu Trp 
        35                  40                  45              


Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn Ser Leu Ala Leu 
    50                  55                  60                  


Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro 
65                  70                  75                  80  


Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala 
                85                  90                  95      


Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His 
            100                 105                 110         


Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu 
        115                 120                 125             


His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met 
    130                 135                 140                 


Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val Lys Leu Leu Phe 
145                 150                 155                 160 


Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly 
                165                 170                 175     


Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg 
            180                 185                 190         


Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile 
        195                 200                 205             


Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser 
    210                 215                 220                 


Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp Lys Ile Thr Asp 
225                 230                 235                 240 


Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln 
                245                 250                 255     


His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His 
            260                 265                 270         


Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys Cys Lys Asn 
        275                 280                 285             


Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Ala Ala Asp Ala His Arg 
    290                 295                 300                 


Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val Glu Glu Thr Asp 
305                 310                 315                 320 


Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser His Ser Leu Gln 
                325                 330                 335     


Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro Ala Thr Ala Val 
            340                 345                 350         


Asp Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Ser Arg Leu 
        355                 360                 365             


Asp Lys Ser Lys Val Ile Asn Gly Ala Leu Glu Leu Leu Asn Gly Val 
    370                 375                 380                 


Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val 
385                 390                 395                 400 


Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu 
                405                 410                 415     


Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His Thr His Phe Cys 
            420                 425                 430         


Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys 
        435                 440                 445             


Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His 
    450                 455                 460                 


Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln 
465                 470                 475                 480 


Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr 
                485                 490                 495     


Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Glu 
            500                 505                 510         


Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp 
        515                 520                 525             


Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp Arg Gln 
    530                 535                 540                 


Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly 
545                 550                 555                 560 


Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala Asp Ala Leu 
                565                 570                 575     


Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe 
            580                 585                 590         


Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        595                 600                 605             


Met Leu Pro Gly Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His 
    610                 615                 620                 


Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Arg Lys Gly Asp Glu Val 
625                 630                 635                 640 


Asp Gly Val Asp Glu Ala Gly Asp Met Arg Ala Ala Asn Leu Trp Pro 
                645                 650                 655     


Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn Ser Leu Ala Leu Ser 
            660                 665                 670         


Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro 
        675                 680                 685             


Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala Ser 
    690                 695                 700                 


Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His Met 
705                 710                 715                 720 


Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu His 
                725                 730                 735     


Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Ile 
            740                 745                 750         


Gly Leu Val Trp Arg Ser Met Glu His Pro Val Lys Leu Leu Phe Ala 
        755                 760                 765             


Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met 
    770                 775                 780                 


Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met 
785                 790                 795                 800 


Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu 
                805                 810                 815     


Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu 
            820                 825                 830         


Glu Glu Lys Asp His Ile His Arg Val Leu Asp Lys Ile Thr Asp Thr 
        835                 840                 845             


Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His 
    850                 855                 860                 


Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His Met 
865                 870                 875                 880 


Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys Cys Lys Asn Val 
                885                 890                 895     


Val Pro Leu Tyr Asp Leu Leu Leu Glu Ala Ala Asp Ala His Arg Leu 
            900                 905                 910         


His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val Glu Glu Thr Asp Gln 
        915                 920                 925             


Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser His Ser Leu Gln Lys 
    930                 935                 940                 


Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro Ala Thr Ala Val Asp 
945                 950                 955                 960 


Asn Leu Val Asp Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu 
                965                 970                 975     


Gln Gln 
        


<210>  5
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lyn11

<400>  5
ggatgtataa aatcaaaagg gaaagacagc gcg                                    33


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lyn11

<400>  6

Gly Cys Ile Lys Ser Lys Gly Lys Asp Ser Ala 
1               5                   10      


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  7
ggagcagata gtgctggtag tgct                                              24


<210>  8
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flexible linker

<400>  8

Gly Ala Asp Ser Ala Gly Ser Ala 
1               5               


<210>  9
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nuclear exclusion signal (NES)

<400>  9
aacctggtgg acctccaaaa gaagctggag gagctggagc tggacgagca gcag             54


<210>  10
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NES

<400>  10

Asn Leu Val Asp Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu 
1               5                   10                  15      


Gln Gln 
        


<210>  11
<211>  945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ERT2

<400>  11
gctggagaca tgagagctgc caacctttgg ccaagcccgc tcatgatcaa acgctctaag       60

aagaacagcc tggccttgtc cctgacggcc gaccagatgg tcagtgcctt gttggatgct      120

gagcccccca tactctattc cgagtatgat cctaccagac ccttcagtga agcttcgatg      180

atgggcttac tgaccaacct ggcagacagg gagctggttc acatgatcaa ctgggcgaag      240

agggtgccag gctttgtgga tttgaccctc catgatcagg tccaccttct agaatgtgcc      300

tggctagaga tcctgatgat tggtctcgtc tggcgctcca tggagcaccc agtgaagcta      360

ctgtttgctc ctaacttgct cttggacagg aaccagggaa aatgtgtaga gggcatggtg      420

gagatcttcg acatgctgct ggctacatca tctcggttcc gcatgatgaa tctgcaggga      480

gaggagtttg tgtgcctcaa atctattatt ttgcttaatt ctggagtgta cacatttctg      540

tccagcaccc tgaagtctct ggaagagaag gaccatatcc accgagtcct ggacaagatc      600

acagacactt tgatccacct gatggccaag gcaggcctga ccctgcagca gcagcaccag      660

cggctggccc agctcctcct catcctctcc cacatcaggc acatgagtaa caaaggcatg      720

gagcatctgt acagcatgaa gtgcaagaac gtggtgcccc tctatgacct gctgctggag      780

gcggcggacg cccaccgcct acatgcgccc actagccgtg gaggggcatc cgtggaggag      840

acggaccaaa gccacttggc cactgcgggc tctacttcat cgcattcctt gcaaaagtat      900

tacatcacgg gggaggcaga gggtttccct gccacagctg tcgac                      945


<210>  12
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERT2

<400>  12

Ala Gly Asp Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile 
1               5                   10                  15      


Lys Arg Ser Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln 
            20                  25                  30          


Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu 
        35                  40                  45              


Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu 
    50                  55                  60                  


Thr Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys 
65                  70                  75                  80  


Arg Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu 
                85                  90                  95      


Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg 
            100                 105                 110         


Ser Met Glu His Pro Val Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu 
        115                 120                 125             


Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp 
    130                 135                 140                 


Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly 
145                 150                 155                 160 


Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val 
                165                 170                 175     


Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His 
            180                 185                 190         


Ile His Arg Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met 
        195                 200                 205             


Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln 
    210                 215                 220                 


Leu Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met 
225                 230                 235                 240 


Glu His Leu Tyr Ser Met Lys Cys Lys Asn Val Val Pro Leu Tyr Asp 
                245                 250                 255     


Leu Leu Leu Glu Ala Ala Asp Ala His Arg Leu His Ala Pro Thr Ser 
            260                 265                 270         


Arg Gly Gly Ala Ser Val Glu Glu Thr Asp Gln Ser His Leu Ala Thr 
        275                 280                 285             


Ala Gly Ser Thr Ser Ser His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly 
    290                 295                 300                 


Glu Ala Glu Gly Phe Pro Ala Thr Ala Val Asp 
305                 310                 315 


<210>  13
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DEVD (PARP)

<400>  13
aagaggaagg gcgacgaggt ggacggcgtg gacgag                                 36


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEVD (PARP)

<400>  14

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu 
1               5                   10          


<210>  15
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DEVD nt

<400>  15
gacgaggtgg ac                                                           12


<210>  16
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEVD AA

<400>  16

Asp Glu Val Asp 
1               


<210>  17
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse tetracycline transactivator

<400>  17
tctagactgg acaagagcaa agtcataaac ggcgctctgg aattactcaa tggagtcggt       60

atcgaaggcc tgacgacaag gaaactcgct caaaagctgg gagttgagca gcctaccctg      120

tactggcacg tgaagaacaa gcgggccctg ctcgatgccc tgccaatcga gatgctggac      180

aggcatcata cccacttctg ccccctggaa ggcgagtcat ggcaagactt tctgcggaac      240

aacgccaagt cattccgctg tgctctcctc tcacatcgcg acggggctaa agtgcatctc      300

ggcacccgcc caacagagaa acagtacgaa accctggaaa atcagctcgc gttcctgtgt      360

cagcaaggct tctccctgga gaacgcactg tacgctctgt ccgccgtggg ccactttaca      420

ctgggctgcg tattggagga acaggagcat caagtagcaa aagaggaaag agagacacct      480

accaccgatt ctatgccccc acttctgaga caagcaattg agctgttcga ccggcaggga      540

gccgaacctg ccttcctttt cggcctggaa ctaatcatat gtggcctgga gaaacagcta      600

aagtgcgaaa gcggcgggcc ggccgacgcc cttgacgatt ttgacttaga catgctccca      660

gccgatgccc ttgacgactt tgaccttgat atgctgcctg ctgacgctct tgacgatttt      720

gaccttgaca tgctccccgg g                                                741


<210>  18
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  reverse tetracycline transactivator

<400>  18

Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Gly Ala Leu Glu Leu Leu 
1               5                   10                  15      


Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys 
            20                  25                  30          


Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg 
        35                  40                  45              


Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His Thr 
    50                  55                  60                  


His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn 
65                  70                  75                  80  


Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala 
                85                  90                  95      


Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu 
            100                 105                 110         


Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn 
        115                 120                 125             


Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val 
    130                 135                 140                 


Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro 
145                 150                 155                 160 


Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe 
                165                 170                 175     


Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile 
            180                 185                 190         


Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala 
        195                 200                 205             


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu 
    210                 215                 220                 


Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe 
225                 230                 235                 240 


Asp Leu Asp Met Leu Pro Gly 
                245         


<210>  19
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3x Flag

<400>  19
gactacaaag accatgacgg tgattataaa gatcatgaca tcgattacaa ggatgacgat       60

gac                                                                     63


<210>  20
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3X Flag

<400>  20

Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
1               5                   10                  15      


Lys Asp Asp Asp Asp 
            20      


<210>  21
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DEVD (PARP) degenerate sequence

<400>  21
aaacgcaaag gtgatgaagt agatggagta gacgaa                                 36


<210>  22
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DEVD (PARP)

<400>  22

Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu 
1               5                   10          


<210>  23
<211>  945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ERT2 (degenerate)

<400>  23
gcaggggata tgcgcgcagc aaacctctgg ccttcacccc tgatgataaa gaggtcaaag       60

aaaaactctc tcgctctgtc actcaccgca gatcaaatgg tgtccgcact gctggacgcc      120

gagcctccaa tattgtacag tgaatacgat cccactcggc ctttttccga ggcctccatg      180

atggggctcc tcacaaatct cgccgatcga gaacttgtgc atatgataaa ttgggccaaa      240

cgagtccctg gtttcgttga tcttactctg cacgaccaag tacatctgct ggagtgcgct      300

tggctggaaa ttctcatgat cgggctggta tggaggagca tggaacatcc cgtcaaactg      360

ctcttcgccc ccaacctctt gctcgaccga aatcagggga agtgcgtgga agggatggta      420

gaaatatttg atatgctcct ggccacaagc agcagattca gaatgatgaa cctccaaggc      480

gaagaattcg tttgtttgaa gagcatcatc ctgctcaaca gcggcgtcta taccttcctc      540

tcctccacgt tgaaaagcct tgaggaaaaa gatcacatcc atagggtact tgataaaatt      600

actgataccc tcatacacct tatggcaaaa gcgggactca cacttcaaca acaacatcaa      660

agactcgcac aattgttgtt gattttgagc catataaggc atatgtcaaa taagggaatg      720

gaacacctct actctatgaa atgtaagaat gtcgtcccac tgtacgatct tctccttgaa      780

gctgcagatg ctcatcggct ccacgcacct acctctcggg gcggcgctag cgttgaagag      840

actgatcagt cacatctcgc gacagctgga agcacaagca gccacagcct ccaaaaatac      900

tatattacag gcgaggccga aggcttcccc gctacggccg tggat                      945


<210>  24
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERT2

<400>  24

Ala Gly Asp Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile 
1               5                   10                  15      


Lys Arg Ser Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln 
            20                  25                  30          


Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu 
        35                  40                  45              


Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu 
    50                  55                  60                  


Thr Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys 
65                  70                  75                  80  


Arg Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu 
                85                  90                  95      


Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg 
            100                 105                 110         


Ser Met Glu His Pro Val Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu 
        115                 120                 125             


Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp 
    130                 135                 140                 


Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly 
145                 150                 155                 160 


Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val 
                165                 170                 175     


Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His 
            180                 185                 190         


Ile His Arg Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met 
        195                 200                 205             


Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln 
    210                 215                 220                 


Leu Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met 
225                 230                 235                 240 


Glu His Leu Tyr Ser Met Lys Cys Lys Asn Val Val Pro Leu Tyr Asp 
                245                 250                 255     


Leu Leu Leu Glu Ala Ala Asp Ala His Arg Leu His Ala Pro Thr Ser 
            260                 265                 270         


Arg Gly Gly Ala Ser Val Glu Glu Thr Asp Gln Ser His Leu Ala Thr 
        275                 280                 285             


Ala Gly Ser Thr Ser Ser His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly 
    290                 295                 300                 


Glu Ala Glu Gly Phe Pro Ala Thr Ala Val Asp 
305                 310                 315 


<210>  25
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NES (degenerate)

<400>  25
aatcttgtag atcttcagaa aaaactcgaa gaacttgagc ttgatgaaca acaa             54


<210>  26
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NES

<400>  26

Asn Leu Val Asp Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu 
1               5                   10                  15      


Gln Gln 
        


<210>  27
<211>  1836
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lyn11-NES-ERT2-DEVD-rtTA NT (with flexible linker following 
       Lyn11)

<400>  27
ggatgtataa aatcaaaagg gaaagacagc gcgggagcag atagtgctgg tagtgctggt       60

aacctggtgg acctccaaaa gaagctggag gagctggagc tggacgagca gcaggctgga      120

gacatgagag ctgccaacct ttggccaagc ccgctcatga tcaaacgctc taagaagaac      180

agcctggcct tgtccctgac ggccgaccag atggtcagtg ccttgttgga tgctgagccc      240

cccatactct attccgagta tgatcctacc agacccttca gtgaagcttc gatgatgggc      300

ttactgacca acctggcaga cagggagctg gttcacatga tcaactgggc gaagagggtg      360

ccaggctttg tggatttgac cctccatgat caggtccacc ttctagaatg tgcctggcta      420

gagatcctga tgattggtct cgtctggcgc tccatggagc acccagtgaa gctactgttt      480

gctcctaact tgctcttgga caggaaccag ggaaaatgtg tagagggcat ggtggagatc      540

ttcgacatgc tgctggctac atcatctcgg ttccgcatga tgaatctgca gggagaggag      600

tttgtgtgcc tcaaatctat tattttgctt aattctggag tgtacacatt tctgtccagc      660

accctgaagt ctctggaaga gaaggaccat atccaccgag tcctggacaa gatcacagac      720

actttgatcc acctgatggc caaggcaggc ctgaccctgc agcagcagca ccagcggctg      780

gcccagctcc tcctcatcct ctcccacatc aggcacatga gtaacaaagg catggagcat      840

ctgtacagca tgaagtgcaa gaacgtggtg cccctctatg acctgctgct ggaggcggcg      900

gacgcccacc gcctacatgc gcccactagc cgtggagggg catccgtgga ggagacggac      960

caaagccact tggccactgc gggctctact tcatcgcatt ccttgcaaaa gtattacatc     1020

acgggggagg cagagggttt ccctgccaca gctgtcgaca agaggaaggg cgacgaggtg     1080

gacggcgtgg acgagtctag actggacaag agcaaagtca taaacggcgc tctggaatta     1140

ctcaatggag tcggtatcga aggcctgacg acaaggaaac tcgctcaaaa gctgggagtt     1200

gagcagccta ccctgtactg gcacgtgaag aacaagcggg ccctgctcga tgccctgcca     1260

atcgagatgc tggacaggca tcatacccac ttctgccccc tggaaggcga gtcatggcaa     1320

gactttctgc ggaacaacgc caagtcattc cgctgtgctc tcctctcaca tcgcgacggg     1380

gctaaagtgc atctcggcac ccgcccaaca gagaaacagt acgaaaccct ggaaaatcag     1440

ctcgcgttcc tgtgtcagca aggcttctcc ctggagaacg cactgtacgc tctgtccgcc     1500

gtgggccact ttacactggg ctgcgtattg gaggaacagg agcatcaagt agcaaaagag     1560

gaaagagaga cacctaccac cgattctatg cccccacttc tgagacaagc aattgagctg     1620

ttcgaccggc agggagccga acctgccttc cttttcggcc tggaactaat catatgtggc     1680

ctggagaaac agctaaagtg cgaaagcggc gggccggccg acgcccttga cgattttgac     1740

ttagacatgc tcccagccga tgcccttgac gactttgacc ttgatatgct gcctgctgac     1800

gctcttgacg attttgacct tgacatgctc cccggg                               1836


<210>  28
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lyn11-NES-ERT2-DEVD-rtTA A (with flexible linker following Lyn11)

<400>  28

Gly Cys Ile Lys Ser Lys Gly Lys Asp Ser Ala Gly Ala Asp Ser Ala 
1               5                   10                  15      


Gly Ser Ala Gly Asn Leu Val Asp Leu Gln Lys Lys Leu Glu Glu Leu 
            20                  25                  30          


Glu Leu Asp Glu Gln Gln Ala Gly Asp Met Arg Ala Ala Asn Leu Trp 
        35                  40                  45              


Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn Ser Leu Ala Leu 
    50                  55                  60                  


Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro 
65                  70                  75                  80  


Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala 
                85                  90                  95      


Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His 
            100                 105                 110         


Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu 
        115                 120                 125             


His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met 
    130                 135                 140                 


Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val Lys Leu Leu Phe 
145                 150                 155                 160 


Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly 
                165                 170                 175     


Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg 
            180                 185                 190         


Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile 
        195                 200                 205             


Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser 
    210                 215                 220                 


Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp Lys Ile Thr Asp 
225                 230                 235                 240 


Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln 
                245                 250                 255     


His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His 
            260                 265                 270         


Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys Cys Lys Asn 
        275                 280                 285             


Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Ala Ala Asp Ala His Arg 
    290                 295                 300                 


Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val Glu Glu Thr Asp 
305                 310                 315                 320 


Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser His Ser Leu Gln 
                325                 330                 335     


Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro Ala Thr Ala Val 
            340                 345                 350         


Asp Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Ser Arg Leu 
        355                 360                 365             


Asp Lys Ser Lys Val Ile Asn Gly Ala Leu Glu Leu Leu Asn Gly Val 
    370                 375                 380                 


Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val 
385                 390                 395                 400 


Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu 
                405                 410                 415     


Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His Thr His Phe Cys 
            420                 425                 430         


Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys 
        435                 440                 445             


Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His 
    450                 455                 460                 


Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln 
465                 470                 475                 480 


Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr 
                485                 490                 495     


Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Glu 
            500                 505                 510         


Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp 
        515                 520                 525             


Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp Arg Gln 
    530                 535                 540                 


Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly 
545                 550                 555                 560 


Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala Asp Ala Leu 
                565                 570                 575     


Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe 
            580                 585                 590         


Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        595                 600                 605             


Met Leu Pro Gly 
    610         


<210>  29
<211>  891
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lyn11-NES- DEVD-rtTA

<400>  29
ggatgtataa aatcaaaagg gaaagacagc gcgggagcag atagtgctgg tagtgctggt       60

aacctggtgg acctccaaaa gaagctggag gagctggagc tggacgagca gcagaagagg      120

aagggcgacg aggtggacgg cgtggacgag tctagactgg acaagagcaa agtcataaac      180

ggcgctctgg aattactcaa tggagtcggt atcgaaggcc tgacgacaag gaaactcgct      240

caaaagctgg gagttgagca gcctaccctg tactggcacg tgaagaacaa gcgggccctg      300

ctcgatgccc tgccaatcga gatgctggac aggcatcata cccacttctg ccccctggaa      360

ggcgagtcat ggcaagactt tctgcggaac aacgccaagt cattccgctg tgctctcctc      420

tcacatcgcg acggggctaa agtgcatctc ggcacccgcc caacagagaa acagtacgaa      480

accctggaaa atcagctcgc gttcctgtgt cagcaaggct tctccctgga gaacgcactg      540

tacgctctgt ccgccgtggg ccactttaca ctgggctgcg tattggagga acaggagcat      600

caagtagcaa aagaggaaag agagacacct accaccgatt ctatgccccc acttctgaga      660

caagcaattg agctgttcga ccggcaggga gccgaacctg ccttcctttt cggcctggaa      720

ctaatcatat gtggcctgga gaaacagcta aagtgcgaaa gcggcgggcc ggccgacgcc      780

cttgacgatt ttgacttaga catgctccca gccgatgccc ttgacgactt tgaccttgat      840

atgctgcctg ctgacgctct tgacgatttt gaccttgaca tgctccccgg g               891


<210>  30
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lyn11-NES- DEVD-rtTA

<400>  30

Gly Cys Ile Lys Ser Lys Gly Lys Asp Ser Ala Gly Ala Asp Ser Ala 
1               5                   10                  15      


Gly Ser Ala Gly Asn Leu Val Asp Leu Gln Lys Lys Leu Glu Glu Leu 
            20                  25                  30          


Glu Leu Asp Glu Gln Gln Lys Arg Lys Gly Asp Glu Val Asp Gly Val 
        35                  40                  45              


Asp Glu Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Gly Ala Leu Glu 
    50                  55                  60                  


Leu Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala 
65                  70                  75                  80  


Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn 
                85                  90                  95      


Lys Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His 
            100                 105                 110         


His Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu 
        115                 120                 125             


Arg Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp 
    130                 135                 140                 


Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu 
145                 150                 155                 160 


Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu 
                165                 170                 175     


Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly 
            180                 185                 190         


Cys Val Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu 
        195                 200                 205             


Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu 
    210                 215                 220                 


Leu Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu 
225                 230                 235                 240 


Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly 
                245                 250                 255     


Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp 
            260                 265                 270         


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp 
        275                 280                 285             


Asp Phe Asp Leu Asp Met Leu Pro Gly 
    290                 295         


<210>  31
<211>  1899
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lyn11-NES-ERT2-DEVD-rtTA-3xFLAG

<400>  31
ggatgtataa aatcaaaagg gaaagacagc gcgggagcag atagtgctgg tagtgctggt       60

aacctggtgg acctccaaaa gaagctggag gagctggagc tggacgagca gcaggctgga      120

gacatgagag ctgccaacct ttggccaagc ccgctcatga tcaaacgctc taagaagaac      180

agcctggcct tgtccctgac ggccgaccag atggtcagtg ccttgttgga tgctgagccc      240

cccatactct attccgagta tgatcctacc agacccttca gtgaagcttc gatgatgggc      300

ttactgacca acctggcaga cagggagctg gttcacatga tcaactgggc gaagagggtg      360

ccaggctttg tggatttgac cctccatgat caggtccacc ttctagaatg tgcctggcta      420

gagatcctga tgattggtct cgtctggcgc tccatggagc acccagtgaa gctactgttt      480

gctcctaact tgctcttgga caggaaccag ggaaaatgtg tagagggcat ggtggagatc      540

ttcgacatgc tgctggctac atcatctcgg ttccgcatga tgaatctgca gggagaggag      600

tttgtgtgcc tcaaatctat tattttgctt aattctggag tgtacacatt tctgtccagc      660

accctgaagt ctctggaaga gaaggaccat atccaccgag tcctggacaa gatcacagac      720

actttgatcc acctgatggc caaggcaggc ctgaccctgc agcagcagca ccagcggctg      780

gcccagctcc tcctcatcct ctcccacatc aggcacatga gtaacaaagg catggagcat      840

ctgtacagca tgaagtgcaa gaacgtggtg cccctctatg acctgctgct ggaggcggcg      900

gacgcccacc gcctacatgc gcccactagc cgtggagggg catccgtgga ggagacggac      960

caaagccact tggccactgc gggctctact tcatcgcatt ccttgcaaaa gtattacatc     1020

acgggggagg cagagggttt ccctgccaca gctgtcgaca agaggaaggg cgacgaggtg     1080

gacggcgtgg acgagtctag actggacaag agcaaagtca taaacggcgc tctggaatta     1140

ctcaatggag tcggtatcga aggcctgacg acaaggaaac tcgctcaaaa gctgggagtt     1200

gagcagccta ccctgtactg gcacgtgaag aacaagcggg ccctgctcga tgccctgcca     1260

atcgagatgc tggacaggca tcatacccac ttctgccccc tggaaggcga gtcatggcaa     1320

gactttctgc ggaacaacgc caagtcattc cgctgtgctc tcctctcaca tcgcgacggg     1380

gctaaagtgc atctcggcac ccgcccaaca gagaaacagt acgaaaccct ggaaaatcag     1440

ctcgcgttcc tgtgtcagca aggcttctcc ctggagaacg cactgtacgc tctgtccgcc     1500

gtgggccact ttacactggg ctgcgtattg gaggaacagg agcatcaagt agcaaaagag     1560

gaaagagaga cacctaccac cgattctatg cccccacttc tgagacaagc aattgagctg     1620

ttcgaccggc agggagccga acctgccttc cttttcggcc tggaactaat catatgtggc     1680

ctggagaaac agctaaagtg cgaaagcggc gggccggccg acgcccttga cgattttgac     1740

ttagacatgc tcccagccga tgcccttgac gactttgacc ttgatatgct gcctgctgac     1800

gctcttgacg attttgacct tgacatgctc cccggggact acaaagacca tgacggtgat     1860

tataaagatc atgacatcga ttacaaggat gacgatgac                            1899


<210>  32
<211>  633
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lyn11-NES-ERT2-DEVD-rtTA-3xFLAG

<400>  32

Gly Cys Ile Lys Ser Lys Gly Lys Asp Ser Ala Gly Ala Asp Ser Ala 
1               5                   10                  15      


Gly Ser Ala Gly Asn Leu Val Asp Leu Gln Lys Lys Leu Glu Glu Leu 
            20                  25                  30          


Glu Leu Asp Glu Gln Gln Ala Gly Asp Met Arg Ala Ala Asn Leu Trp 
        35                  40                  45              


Pro Ser Pro Leu Met Ile Lys Arg Ser Lys Lys Asn Ser Leu Ala Leu 
    50                  55                  60                  


Ser Leu Thr Ala Asp Gln Met Val Ser Ala Leu Leu Asp Ala Glu Pro 
65                  70                  75                  80  


Pro Ile Leu Tyr Ser Glu Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala 
                85                  90                  95      


Ser Met Met Gly Leu Leu Thr Asn Leu Ala Asp Arg Glu Leu Val His 
            100                 105                 110         


Met Ile Asn Trp Ala Lys Arg Val Pro Gly Phe Val Asp Leu Thr Leu 
        115                 120                 125             


His Asp Gln Val His Leu Leu Glu Cys Ala Trp Leu Glu Ile Leu Met 
    130                 135                 140                 


Ile Gly Leu Val Trp Arg Ser Met Glu His Pro Val Lys Leu Leu Phe 
145                 150                 155                 160 


Ala Pro Asn Leu Leu Leu Asp Arg Asn Gln Gly Lys Cys Val Glu Gly 
                165                 170                 175     


Met Val Glu Ile Phe Asp Met Leu Leu Ala Thr Ser Ser Arg Phe Arg 
            180                 185                 190         


Met Met Asn Leu Gln Gly Glu Glu Phe Val Cys Leu Lys Ser Ile Ile 
        195                 200                 205             


Leu Leu Asn Ser Gly Val Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser 
    210                 215                 220                 


Leu Glu Glu Lys Asp His Ile His Arg Val Leu Asp Lys Ile Thr Asp 
225                 230                 235                 240 


Thr Leu Ile His Leu Met Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln 
                245                 250                 255     


His Gln Arg Leu Ala Gln Leu Leu Leu Ile Leu Ser His Ile Arg His 
            260                 265                 270         


Met Ser Asn Lys Gly Met Glu His Leu Tyr Ser Met Lys Cys Lys Asn 
        275                 280                 285             


Val Val Pro Leu Tyr Asp Leu Leu Leu Glu Ala Ala Asp Ala His Arg 
    290                 295                 300                 


Leu His Ala Pro Thr Ser Arg Gly Gly Ala Ser Val Glu Glu Thr Asp 
305                 310                 315                 320 


Gln Ser His Leu Ala Thr Ala Gly Ser Thr Ser Ser His Ser Leu Gln 
                325                 330                 335     


Lys Tyr Tyr Ile Thr Gly Glu Ala Glu Gly Phe Pro Ala Thr Ala Val 
            340                 345                 350         


Asp Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Ser Arg Leu 
        355                 360                 365             


Asp Lys Ser Lys Val Ile Asn Gly Ala Leu Glu Leu Leu Asn Gly Val 
    370                 375                 380                 


Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly Val 
385                 390                 395                 400 


Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu Leu 
                405                 410                 415     


Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His Thr His Phe Cys 
            420                 425                 430         


Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys 
        435                 440                 445             


Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val His 
    450                 455                 460                 


Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln 
465                 470                 475                 480 


Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr 
                485                 490                 495     


Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu Glu 
            500                 505                 510         


Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp 
        515                 520                 525             


Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp Arg Gln 
    530                 535                 540                 


Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly 
545                 550                 555                 560 


Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala Asp Ala Leu 
                565                 570                 575     


Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe 
            580                 585                 590         


Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        595                 600                 605             


Met Leu Pro Gly Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His 
    610                 615                 620                 


Asp Ile Asp Tyr Lys Asp Asp Asp Asp 
625                 630             


<210>  33
<211>  954
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lyn11-NES- DEVD-rtTA-3xFLAG

<400>  33
ggatgtataa aatcaaaagg gaaagacagc gcgggagcag atagtgctgg tagtgctggt       60

aacctggtgg acctccaaaa gaagctggag gagctggagc tggacgagca gcagaagagg      120

aagggcgacg aggtggacgg cgtggacgag tctagactgg acaagagcaa agtcataaac      180

ggcgctctgg aattactcaa tggagtcggt atcgaaggcc tgacgacaag gaaactcgct      240

caaaagctgg gagttgagca gcctaccctg tactggcacg tgaagaacaa gcgggccctg      300

ctcgatgccc tgccaatcga gatgctggac aggcatcata cccacttctg ccccctggaa      360

ggcgagtcat ggcaagactt tctgcggaac aacgccaagt cattccgctg tgctctcctc      420

tcacatcgcg acggggctaa agtgcatctc ggcacccgcc caacagagaa acagtacgaa      480

accctggaaa atcagctcgc gttcctgtgt cagcaaggct tctccctgga gaacgcactg      540

tacgctctgt ccgccgtggg ccactttaca ctgggctgcg tattggagga acaggagcat      600

caagtagcaa aagaggaaag agagacacct accaccgatt ctatgccccc acttctgaga      660

caagcaattg agctgttcga ccggcaggga gccgaacctg ccttcctttt cggcctggaa      720

ctaatcatat gtggcctgga gaaacagcta aagtgcgaaa gcggcgggcc ggccgacgcc      780

cttgacgatt ttgacttaga catgctccca gccgatgccc ttgacgactt tgaccttgat      840

atgctgcctg ctgacgctct tgacgatttt gaccttgaca tgctccccgg ggactacaaa      900

gaccatgacg gtgattataa agatcatgac atcgattaca aggatgacga tgac            954


<210>  34
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Lyn11-NES- DEVD-rtTA-3xFLAG

<400>  34

Gly Cys Ile Lys Ser Lys Gly Lys Asp Ser Ala Gly Ala Asp Ser Ala 
1               5                   10                  15      


Gly Ser Ala Gly Asn Leu Val Asp Leu Gln Lys Lys Leu Glu Glu Leu 
            20                  25                  30          


Glu Leu Asp Glu Gln Gln Lys Arg Lys Gly Asp Glu Val Asp Gly Val 
        35                  40                  45              


Asp Glu Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Gly Ala Leu Glu 
    50                  55                  60                  


Leu Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala 
65                  70                  75                  80  


Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn 
                85                  90                  95      


Lys Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His 
            100                 105                 110         


His Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu 
        115                 120                 125             


Arg Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp 
    130                 135                 140                 


Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu 
145                 150                 155                 160 


Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu 
                165                 170                 175     


Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly 
            180                 185                 190         


Cys Val Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu 
        195                 200                 205             


Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu 
    210                 215                 220                 


Leu Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu 
225                 230                 235                 240 


Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly 
                245                 250                 255     


Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp 
            260                 265                 270         


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp 
        275                 280                 285             


Asp Phe Asp Leu Asp Met Leu Pro Gly Asp Tyr Lys Asp His Asp Gly 
    290                 295                 300                 


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp 
305                 310                 315             


<210>  35
<211>  2769
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ERT2-DEVD-rtTA-3xFLAG-DEVD-ERT2 NT with GCA after flag

<400>  35
gctggagaca tgagagctgc caacctttgg ccaagcccgc tcatgatcaa acgctctaag       60

aagaacagcc tggccttgtc cctgacggcc gaccagatgg tcagtgcctt gttggatgct      120

gagcccccca tactctattc cgagtatgat cctaccagac ccttcagtga agcttcgatg      180

atgggcttac tgaccaacct ggcagacagg gagctggttc acatgatcaa ctgggcgaag      240

agggtgccag gctttgtgga tttgaccctc catgatcagg tccaccttct agaatgtgcc      300

tggctagaga tcctgatgat tggtctcgtc tggcgctcca tggagcaccc agtgaagcta      360

ctgtttgctc ctaacttgct cttggacagg aaccagggaa aatgtgtaga gggcatggtg      420

gagatcttcg acatgctgct ggctacatca tctcggttcc gcatgatgaa tctgcaggga      480

gaggagtttg tgtgcctcaa atctattatt ttgcttaatt ctggagtgta cacatttctg      540

tccagcaccc tgaagtctct ggaagagaag gaccatatcc accgagtcct ggacaagatc      600

acagacactt tgatccacct gatggccaag gcaggcctga ccctgcagca gcagcaccag      660

cggctggccc agctcctcct catcctctcc cacatcaggc acatgagtaa caaaggcatg      720

gagcatctgt acagcatgaa gtgcaagaac gtggtgcccc tctatgacct gctgctggag      780

gcggcggacg cccaccgcct acatgcgccc actagccgtg gaggggcatc cgtggaggag      840

acggaccaaa gccacttggc cactgcgggc tctacttcat cgcattcctt gcaaaagtat      900

tacatcacgg gggaggcaga gggtttccct gccacagctg tcgacaagag gaagggcgac      960

gaggtggacg gcgtggacga gtctagactg gacaagagca aagtcataaa cggcgctctg     1020

gaattactca atggagtcgg tatcgaaggc ctgacgacaa ggaaactcgc tcaaaagctg     1080

ggagttgagc agcctaccct gtactggcac gtgaagaaca agcgggccct gctcgatgcc     1140

ctgccaatcg agatgctgga caggcatcat acccacttct gccccctgga aggcgagtca     1200

tggcaagact ttctgcggaa caacgccaag tcattccgct gtgctctcct ctcacatcgc     1260

gacggggcta aagtgcatct cggcacccgc ccaacagaga aacagtacga aaccctggaa     1320

aatcagctcg cgttcctgtg tcagcaaggc ttctccctgg agaacgcact gtacgctctg     1380

tccgccgtgg gccactttac actgggctgc gtattggagg aacaggagca tcaagtagca     1440

aaagaggaaa gagagacacc taccaccgat tctatgcccc cacttctgag acaagcaatt     1500

gagctgttcg accggcaggg agccgaacct gccttccttt tcggcctgga actaatcata     1560

tgtggcctgg agaaacagct aaagtgcgaa agcggcgggc cggccgacgc ccttgacgat     1620

tttgacttag acatgctccc agccgatgcc cttgacgact ttgaccttga tatgctgcct     1680

gctgacgctc ttgacgattt tgaccttgac atgctccccg gggactacaa agaccatgac     1740

ggtgattata aagatcatga catcgattac aaggatgacg atgacgcaaa acgcaaaggt     1800

gatgaagtag atggagtaga cgaagcaggg gatatgcgcg cagcaaacct ctggccttca     1860

cccctgatga taaagaggtc aaagaaaaac tctctcgctc tgtcactcac cgcagatcaa     1920

atggtgtccg cactgctgga cgccgagcct ccaatattgt acagtgaata cgatcccact     1980

cggccttttt ccgaggcctc catgatgggg ctcctcacaa atctcgccga tcgagaactt     2040

gtgcatatga taaattgggc caaacgagtc cctggtttcg ttgatcttac tctgcacgac     2100

caagtacatc tgctggagtg cgcttggctg gaaattctca tgatcgggct ggtatggagg     2160

agcatggaac atcccgtcaa actgctcttc gcccccaacc tcttgctcga ccgaaatcag     2220

gggaagtgcg tggaagggat ggtagaaata tttgatatgc tcctggccac aagcagcaga     2280

ttcagaatga tgaacctcca aggcgaagaa ttcgtttgtt tgaagagcat catcctgctc     2340

aacagcggcg tctatacctt cctctcctcc acgttgaaaa gccttgagga aaaagatcac     2400

atccataggg tacttgataa aattactgat accctcatac accttatggc aaaagcggga     2460

ctcacacttc aacaacaaca tcaaagactc gcacaattgt tgttgatttt gagccatata     2520

aggcatatgt caaataaggg aatggaacac ctctactcta tgaaatgtaa gaatgtcgtc     2580

ccactgtacg atcttctcct tgaagctgca gatgctcatc ggctccacgc acctacctct     2640

cggggcggcg ctagcgttga agagactgat cagtcacatc tcgcgacagc tggaagcaca     2700

agcagccaca gcctccaaaa atactatatt acaggcgagg ccgaaggctt ccccgctacg     2760

gccgtggat                                                             2769


<210>  36
<211>  923
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERT2-DEVD-rtTA-3xFLAG-DEVD-ERT2

<400>  36

Ala Gly Asp Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile 
1               5                   10                  15      


Lys Arg Ser Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln 
            20                  25                  30          


Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu 
        35                  40                  45              


Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu 
    50                  55                  60                  


Thr Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys 
65                  70                  75                  80  


Arg Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu 
                85                  90                  95      


Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg 
            100                 105                 110         


Ser Met Glu His Pro Val Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu 
        115                 120                 125             


Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp 
    130                 135                 140                 


Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly 
145                 150                 155                 160 


Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val 
                165                 170                 175     


Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His 
            180                 185                 190         


Ile His Arg Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met 
        195                 200                 205             


Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln 
    210                 215                 220                 


Leu Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met 
225                 230                 235                 240 


Glu His Leu Tyr Ser Met Lys Cys Lys Asn Val Val Pro Leu Tyr Asp 
                245                 250                 255     


Leu Leu Leu Glu Ala Ala Asp Ala His Arg Leu His Ala Pro Thr Ser 
            260                 265                 270         


Arg Gly Gly Ala Ser Val Glu Glu Thr Asp Gln Ser His Leu Ala Thr 
        275                 280                 285             


Ala Gly Ser Thr Ser Ser His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly 
    290                 295                 300                 


Glu Ala Glu Gly Phe Pro Ala Thr Ala Val Asp Lys Arg Lys Gly Asp 
305                 310                 315                 320 


Glu Val Asp Gly Val Asp Glu Ser Arg Leu Asp Lys Ser Lys Val Ile 
                325                 330                 335     


Asn Gly Ala Leu Glu Leu Leu Asn Gly Val Gly Ile Glu Gly Leu Thr 
            340                 345                 350         


Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr 
        355                 360                 365             


Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu 
    370                 375                 380                 


Met Leu Asp Arg His His Thr His Phe Cys Pro Leu Glu Gly Glu Ser 
385                 390                 395                 400 


Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu 
                405                 410                 415     


Leu Ser His Arg Asp Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr 
            420                 425                 430         


Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln 
        435                 440                 445             


Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly 
    450                 455                 460                 


His Phe Thr Leu Gly Cys Val Leu Glu Glu Gln Glu His Gln Val Ala 
465                 470                 475                 480 


Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu 
                485                 490                 495     


Arg Gln Ala Ile Glu Leu Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe 
            500                 505                 510         


Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys 
        515                 520                 525             


Cys Glu Ser Gly Gly Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
    530                 535                 540                 


Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro 
545                 550                 555                 560 


Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly Asp Tyr 
                565                 570                 575     


Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp 
            580                 585                 590         


Asp Asp Asp Ala Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu 
        595                 600                 605             


Ala Gly Asp Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile 
    610                 615                 620                 


Lys Arg Ser Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln 
625                 630                 635                 640 


Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu 
                645                 650                 655     


Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu 
            660                 665                 670         


Thr Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys 
        675                 680                 685             


Arg Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu 
    690                 695                 700                 


Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg 
705                 710                 715                 720 


Ser Met Glu His Pro Val Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu 
                725                 730                 735     


Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp 
            740                 745                 750         


Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly 
        755                 760                 765             


Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val 
    770                 775                 780                 


Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His 
785                 790                 795                 800 


Ile His Arg Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met 
                805                 810                 815     


Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln 
            820                 825                 830         


Leu Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met 
        835                 840                 845             


Glu His Leu Tyr Ser Met Lys Cys Lys Asn Val Val Pro Leu Tyr Asp 
    850                 855                 860                 


Leu Leu Leu Glu Ala Ala Asp Ala His Arg Leu His Ala Pro Thr Ser 
865                 870                 875                 880 


Arg Gly Gly Ala Ser Val Glu Glu Thr Asp Gln Ser His Leu Ala Thr 
                885                 890                 895     


Ala Gly Ser Thr Ser Ser His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly 
            900                 905                 910         


Glu Ala Glu Gly Phe Pro Ala Thr Ala Val Asp 
        915                 920             


<210>  37
<211>  2766
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ERT2-DEVD-rtTA-3xFLAG-DEVD-ERT2 NT w/out GCA after flag

<400>  37
gctggagaca tgagagctgc caacctttgg ccaagcccgc tcatgatcaa acgctctaag       60

aagaacagcc tggccttgtc cctgacggcc gaccagatgg tcagtgcctt gttggatgct      120

gagcccccca tactctattc cgagtatgat cctaccagac ccttcagtga agcttcgatg      180

atgggcttac tgaccaacct ggcagacagg gagctggttc acatgatcaa ctgggcgaag      240

agggtgccag gctttgtgga tttgaccctc catgatcagg tccaccttct agaatgtgcc      300

tggctagaga tcctgatgat tggtctcgtc tggcgctcca tggagcaccc agtgaagcta      360

ctgtttgctc ctaacttgct cttggacagg aaccagggaa aatgtgtaga gggcatggtg      420

gagatcttcg acatgctgct ggctacatca tctcggttcc gcatgatgaa tctgcaggga      480

gaggagtttg tgtgcctcaa atctattatt ttgcttaatt ctggagtgta cacatttctg      540

tccagcaccc tgaagtctct ggaagagaag gaccatatcc accgagtcct ggacaagatc      600

acagacactt tgatccacct gatggccaag gcaggcctga ccctgcagca gcagcaccag      660

cggctggccc agctcctcct catcctctcc cacatcaggc acatgagtaa caaaggcatg      720

gagcatctgt acagcatgaa gtgcaagaac gtggtgcccc tctatgacct gctgctggag      780

gcggcggacg cccaccgcct acatgcgccc actagccgtg gaggggcatc cgtggaggag      840

acggaccaaa gccacttggc cactgcgggc tctacttcat cgcattcctt gcaaaagtat      900

tacatcacgg gggaggcaga gggtttccct gccacagctg tcgacaagag gaagggcgac      960

gaggtggacg gcgtggacga gtctagactg gacaagagca aagtcataaa cggcgctctg     1020

gaattactca atggagtcgg tatcgaaggc ctgacgacaa ggaaactcgc tcaaaagctg     1080

ggagttgagc agcctaccct gtactggcac gtgaagaaca agcgggccct gctcgatgcc     1140

ctgccaatcg agatgctgga caggcatcat acccacttct gccccctgga aggcgagtca     1200

tggcaagact ttctgcggaa caacgccaag tcattccgct gtgctctcct ctcacatcgc     1260

gacggggcta aagtgcatct cggcacccgc ccaacagaga aacagtacga aaccctggaa     1320

aatcagctcg cgttcctgtg tcagcaaggc ttctccctgg agaacgcact gtacgctctg     1380

tccgccgtgg gccactttac actgggctgc gtattggagg aacaggagca tcaagtagca     1440

aaagaggaaa gagagacacc taccaccgat tctatgcccc cacttctgag acaagcaatt     1500

gagctgttcg accggcaggg agccgaacct gccttccttt tcggcctgga actaatcata     1560

tgtggcctgg agaaacagct aaagtgcgaa agcggcgggc cggccgacgc ccttgacgat     1620

tttgacttag acatgctccc agccgatgcc cttgacgact ttgaccttga tatgctgcct     1680

gctgacgctc ttgacgattt tgaccttgac atgctccccg gggactacaa agaccatgac     1740

ggtgattata aagatcatga catcgattac aaggatgacg atgacaaacg caaaggtgat     1800

gaagtagatg gagtagacga agcaggggat atgcgcgcag caaacctctg gccttcaccc     1860

ctgatgataa agaggtcaaa gaaaaactct ctcgctctgt cactcaccgc agatcaaatg     1920

gtgtccgcac tgctggacgc cgagcctcca atattgtaca gtgaatacga tcccactcgg     1980

cctttttccg aggcctccat gatggggctc ctcacaaatc tcgccgatcg agaacttgtg     2040

catatgataa attgggccaa acgagtccct ggtttcgttg atcttactct gcacgaccaa     2100

gtacatctgc tggagtgcgc ttggctggaa attctcatga tcgggctggt atggaggagc     2160

atggaacatc ccgtcaaact gctcttcgcc cccaacctct tgctcgaccg aaatcagggg     2220

aagtgcgtgg aagggatggt agaaatattt gatatgctcc tggccacaag cagcagattc     2280

agaatgatga acctccaagg cgaagaattc gtttgtttga agagcatcat cctgctcaac     2340

agcggcgtct ataccttcct ctcctccacg ttgaaaagcc ttgaggaaaa agatcacatc     2400

catagggtac ttgataaaat tactgatacc ctcatacacc ttatggcaaa agcgggactc     2460

acacttcaac aacaacatca aagactcgca caattgttgt tgattttgag ccatataagg     2520

catatgtcaa ataagggaat ggaacacctc tactctatga aatgtaagaa tgtcgtccca     2580

ctgtacgatc ttctccttga agctgcagat gctcatcggc tccacgcacc tacctctcgg     2640

ggcggcgcta gcgttgaaga gactgatcag tcacatctcg cgacagctgg aagcacaagc     2700

agccacagcc tccaaaaata ctatattaca ggcgaggccg aaggcttccc cgctacggcc     2760

gtggat                                                                2766


<210>  38
<211>  922
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ERT2-DEVD-rtTA-3xFLAG-DEVD-ERT2 NT w/out GCA after flag

<400>  38

Ala Gly Asp Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile 
1               5                   10                  15      


Lys Arg Ser Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln 
            20                  25                  30          


Met Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu 
        35                  40                  45              


Tyr Asp Pro Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu 
    50                  55                  60                  


Thr Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys 
65                  70                  75                  80  


Arg Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu 
                85                  90                  95      


Leu Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg 
            100                 105                 110         


Ser Met Glu His Pro Val Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu 
        115                 120                 125             


Asp Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp 
    130                 135                 140                 


Met Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly 
145                 150                 155                 160 


Glu Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val 
                165                 170                 175     


Tyr Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His 
            180                 185                 190         


Ile His Arg Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met 
        195                 200                 205             


Ala Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln 
    210                 215                 220                 


Leu Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met 
225                 230                 235                 240 


Glu His Leu Tyr Ser Met Lys Cys Lys Asn Val Val Pro Leu Tyr Asp 
                245                 250                 255     


Leu Leu Leu Glu Ala Ala Asp Ala His Arg Leu His Ala Pro Thr Ser 
            260                 265                 270         


Arg Gly Gly Ala Ser Val Glu Glu Thr Asp Gln Ser His Leu Ala Thr 
        275                 280                 285             


Ala Gly Ser Thr Ser Ser His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly 
    290                 295                 300                 


Glu Ala Glu Gly Phe Pro Ala Thr Ala Val Asp Lys Arg Lys Gly Asp 
305                 310                 315                 320 


Glu Val Asp Gly Val Asp Glu Ser Arg Leu Asp Lys Ser Lys Val Ile 
                325                 330                 335     


Asn Gly Ala Leu Glu Leu Leu Asn Gly Val Gly Ile Glu Gly Leu Thr 
            340                 345                 350         


Thr Arg Lys Leu Ala Gln Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr 
        355                 360                 365             


Trp His Val Lys Asn Lys Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu 
    370                 375                 380                 


Met Leu Asp Arg His His Thr His Phe Cys Pro Leu Glu Gly Glu Ser 
385                 390                 395                 400 


Trp Gln Asp Phe Leu Arg Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu 
                405                 410                 415     


Leu Ser His Arg Asp Gly Ala Lys Val His Leu Gly Thr Arg Pro Thr 
            420                 425                 430         


Glu Lys Gln Tyr Glu Thr Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln 
        435                 440                 445             


Gln Gly Phe Ser Leu Glu Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly 
    450                 455                 460                 


His Phe Thr Leu Gly Cys Val Leu Glu Glu Gln Glu His Gln Val Ala 
465                 470                 475                 480 


Lys Glu Glu Arg Glu Thr Pro Thr Thr Asp Ser Met Pro Pro Leu Leu 
                485                 490                 495     


Arg Gln Ala Ile Glu Leu Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe 
            500                 505                 510         


Leu Phe Gly Leu Glu Leu Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys 
        515                 520                 525             


Cys Glu Ser Gly Gly Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
    530                 535                 540                 


Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro 
545                 550                 555                 560 


Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly Asp Tyr 
                565                 570                 575     


Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp 
            580                 585                 590         


Asp Asp Asp Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Ala 
        595                 600                 605             


Gly Asp Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys 
    610                 615                 620                 


Arg Ser Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met 
625                 630                 635                 640 


Val Ser Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr 
                645                 650                 655     


Asp Pro Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr 
            660                 665                 670         


Asn Leu Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg 
        675                 680                 685             


Val Pro Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu Leu 
    690                 695                 700                 


Glu Cys Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser 
705                 710                 715                 720 


Met Glu His Pro Val Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp 
                725                 730                 735     


Arg Asn Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met 
            740                 745                 750         


Leu Leu Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu 
        755                 760                 765             


Glu Phe Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr 
    770                 775                 780                 


Thr Phe Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile 
785                 790                 795                 800 


His Arg Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala 
                805                 810                 815     


Lys Ala Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu 
            820                 825                 830         


Leu Leu Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu 
        835                 840                 845             


His Leu Tyr Ser Met Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu 
    850                 855                 860                 


Leu Leu Glu Ala Ala Asp Ala His Arg Leu His Ala Pro Thr Ser Arg 
865                 870                 875                 880 


Gly Gly Ala Ser Val Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala 
                885                 890                 895     


Gly Ser Thr Ser Ser His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu 
            900                 905                 910         


Ala Glu Gly Phe Pro Ala Thr Ala Val Asp 
        915                 920         


<210>  39
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MCD8-NES- DEVD-rtTA

<400>  39
atggcctcac cgttgacccg ctttctgtcg ctgaacctgc tgctgctggg tgagtcgatt       60

atcctgggga gtggagaagc taagccacag gcacccgaac tccgaatctt tccaaagaaa      120

atggacgccg aacttggtca gaaggtggac ctggtatgtg aagtgttggg gtccgtttcg      180

caaggatgct cttggctctt ccagaactcc agctccaaac tcccccagcc caccttcgtt      240

gtctatatgg cttcatccca caacaagata acgtgggacg agaagctgaa ttcgtcgaaa      300

ctgttttctg ccatgaggga cacgaataat aagtacgttc tcaccctgaa caagttcagc      360

aaggaaaacg aaggctacta tttctgctca gtcatcagca actcggtgat gtacttcagt      420

tctgtcgtgc cagtccttca gaaagtgaac tctactacta ccaagccagt gctgcgaact      480

ccctcacctg tgcaccctac cgggacatct cagccccaga gaccagaaga ttgtcggccc      540

cgtggctcag tgaaggggac cggattggac ttcgcctgtg atatttacat ctgggcaccc      600

ttggccggaa tctgcgtggc ccttctgctg tccttgatca tcactctcat ctgctaccac      660

agccgcggat ctaacctggt ggacctccaa aagaagctgg aggagctgga gctggacgag      720

cagcagaaga ggaagggcga cgaggtggac ggcgtggacg agtctagact ggacaagagc      780

aaagtcataa acggcgctct ggaattactc aatggagtcg gtatcgaagg cctgacgaca      840

aggaaactcg ctcaaaagct gggagttgag cagcctaccc tgtactggca cgtgaagaac      900

aagcgggccc tgctcgatgc cctgccaatc gagatgctgg acaggcatca tacccacttc      960

tgccccctgg aaggcgagtc atggcaagac tttctgcgga acaacgccaa gtcattccgc     1020

tgtgctctcc tctcacatcg cgacggggct aaagtgcatc tcggcacccg cccaacagag     1080

aaacagtacg aaaccctgga aaatcagctc gcgttcctgt gtcagcaagg cttctccctg     1140

gagaacgcac tgtacgctct gtccgccgtg ggccacttta cactgggctg cgtattggag     1200

gaacaggagc atcaagtagc aaaagaggaa agagagacac ctaccaccga ttctatgccc     1260

ccacttctga gacaagcaat tgagctgttc gaccggcagg gagccgaacc tgccttcctt     1320

ttcggcctgg aactaatcat atgtggcctg gagaaacagc taaagtgcga aagcggcggg     1380

ccggccgacg cccttgacga ttttgactta gacatgctcc cagccgatgc ccttgacgac     1440

tttgaccttg atatgctgcc tgctgacgct cttgacgatt ttgaccttga catgctcccc     1500

ggg                                                                   1503


<210>  40
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MCD8-NES- DEVD-rtTA

<400>  40

Met Ala Ser Pro Leu Thr Arg Phe Leu Ser Leu Asn Leu Leu Leu Leu 
1               5                   10                  15      


Gly Glu Ser Ile Ile Leu Gly Ser Gly Glu Ala Lys Pro Gln Ala Pro 
            20                  25                  30          


Glu Leu Arg Ile Phe Pro Lys Lys Met Asp Ala Glu Leu Gly Gln Lys 
        35                  40                  45              


Val Asp Leu Val Cys Glu Val Leu Gly Ser Val Ser Gln Gly Cys Ser 
    50                  55                  60                  


Trp Leu Phe Gln Asn Ser Ser Ser Lys Leu Pro Gln Pro Thr Phe Val 
65                  70                  75                  80  


Val Tyr Met Ala Ser Ser His Asn Lys Ile Thr Trp Asp Glu Lys Leu 
                85                  90                  95      


Asn Ser Ser Lys Leu Phe Ser Ala Met Arg Asp Thr Asn Asn Lys Tyr 
            100                 105                 110         


Val Leu Thr Leu Asn Lys Phe Ser Lys Glu Asn Glu Gly Tyr Tyr Phe 
        115                 120                 125             


Cys Ser Val Ile Ser Asn Ser Val Met Tyr Phe Ser Ser Val Val Pro 
    130                 135                 140                 


Val Leu Gln Lys Val Asn Ser Thr Thr Thr Lys Pro Val Leu Arg Thr 
145                 150                 155                 160 


Pro Ser Pro Val His Pro Thr Gly Thr Ser Gln Pro Gln Arg Pro Glu 
                165                 170                 175     


Asp Cys Arg Pro Arg Gly Ser Val Lys Gly Thr Gly Leu Asp Phe Ala 
            180                 185                 190         


Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Ile Cys Val Ala Leu 
        195                 200                 205             


Leu Leu Ser Leu Ile Ile Thr Leu Ile Cys Tyr His Ser Arg Gly Ser 
    210                 215                 220                 


Asn Leu Val Asp Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp Glu 
225                 230                 235                 240 


Gln Gln Lys Arg Lys Gly Asp Glu Val Asp Gly Val Asp Glu Ser Arg 
                245                 250                 255     


Leu Asp Lys Ser Lys Val Ile Asn Gly Ala Leu Glu Leu Leu Asn Gly 
            260                 265                 270         


Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln Lys Leu Gly 
        275                 280                 285             


Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys Arg Ala Leu 
    290                 295                 300                 


Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His Thr His Phe 
305                 310                 315                 320 


Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg Asn Asn Ala 
                325                 330                 335     


Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly Ala Lys Val 
            340                 345                 350         


His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr Leu Glu Asn 
        355                 360                 365             


Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu Asn Ala Leu 
    370                 375                 380                 


Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys Val Leu Glu 
385                 390                 395                 400 


Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr Pro Thr Thr 
                405                 410                 415     


Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu Phe Asp Arg 
            420                 425                 430         


Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu Ile Ile Cys 
        435                 440                 445             


Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro Ala Asp Ala 
    450                 455                 460                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp 
465                 470                 475                 480 


Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu 
                485                 490                 495     


Asp Met Leu Pro Gly 
            500     


<210>  41
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mito-CAVP (N-terminal end of SMAC)

<400>  41
atggcggctc tgaagagttg gctgtcgccc atcgtaactt cattcttcag gtacagacag       60

tgtttgtgtg ttcctgttgt ggctaacttt aagaagcggt gtttctcaga attgataaga      120

ccatggcaca aaactgtgac gattggcttt ggagtaaccc tgtgtgcggt tcctattgca      180

cagaaatcag agcctcattc cctt                                             204


<210>  42
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mito-CAVP (N-terminal end of SMAC)

<400>  42

Met Ala Ala Leu Lys Ser Trp Leu Ser Arg Ser Val Thr Ser Phe Phe 
1               5                   10                  15      


Arg Tyr Arg Gln Cys Leu Cys Val Pro Val Val Ala Asn Phe Lys Lys 
            20                  25                  30          


Arg Cys Phe Ser Glu Leu Ile Arg Pro Trp His Lys Thr Val Thr Ile 
        35                  40                  45              


Gly Phe Gly Val Thr Leu Cys Ala Val Pro Ile Ala Gln Ala Val Tyr 
    50                  55                  60                  


Thr Leu Thr Ser 
65              


<210>  43
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Gal4-VP16 transactivator

<400>  43
atgaagctac tgtcttctat cgaacaagca tgcgatattt gccgacttaa aaagctcaag       60

tgctccaaag aaaaaccgaa gtgcgccaag tgtctgaaga acaactggga gtgtcgctac      120

tctcccaaaa ccaaaaggtc tccgctgact agggcacatc tgacagaagt ggaatcaagg      180

ctagaaagac tggaacagct atttctactg atttttcctc gagaagacct tgacatgatt      240

ttgaaaatgg attctttaca ggatataaaa gcattgttaa caggattatt tgtacaagat      300

aatgtgaata aagatgccgt cacagataga ttggcttcag tggagactga tatgcctcta      360

acattgagac agcatagaat aagtgcgaca tcatcatcgg aagagagtag taacaaaggt      420

caaagacagt tgactgtatc gatgggccct aaaaagaagc gtaaagtcgc ccccccgacc      480

gatgtcagcc tgggggacga gctccactta gacggcgagg acgtggcgat ggcgcatgcc      540

gacgcgctag acgatttcga tctggacatg ttgggggacg gggattcccc gggtccggga      600

tttacccccc acgactccgc cccctacggc gctctggata tggccgactt cgagtttgag      660

cagatgttta ccgatgccct tggaattgac gagtacggtg ggtag                      705


<210>  44
<211>  1272
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FLPo recombinase

<400>  44
atgagccagt tcgacatcct gtgcaagacc ccccccaagg tgctggtgcg gcagttcgtg       60

gagagattcg agaggcccag cggcgagaag atcgccagct gtgccgccga gctgacctac      120

ctgtgctgga tgatcaccca caacggcacc gccatcaaga gggccacctt catgagctac      180

aacaccatca tcagcaacag cctgagcttc gacatcgtga acaagagcct gcagttcaag      240

tacaagaccc agaaggccac catcctggag gccagcctga agaagctgat ccccgcctgg      300

gagttcacca tcatccctta caacggccag aagcaccaga gcgacatcac cgacatcgtg      360

tccagcctgc agctgcagtt cgagagcagc gaggaggccg acaagggcaa cagccacagc      420

aagaagatgc tgaaggccct gctgtccgag ggcgagagca tctgggagat caccgagaag      480

atcctgaaca gcttcgagta caccagcagg ttcaccaaga ccaagaccct gtaccagttc      540

ctgttcctgg ccacattcat caactgcggc aggttcagcg acatcaagaa cgtggacccc      600

aagagcttca agctggtgca gaacaagtac ctgggcgtga tcattcagtg cctggtgacc      660

gagaccaaga caagcgtgtc caggcacatc tactttttca gcgccagagg caggatcgac      720

cccctggtgt acctggacga gttcctgagg aacagcgagc ccgtgctgaa gagagtgaac      780

aggaccggca acagcagcag caacaagcag gagtaccagc tgctgaagga caacctggtg      840

cgcagctaca acaaggccct gaagaagaac gccccctacc ccatcttcgc tatcaagaac      900

ggccctaaga gccacatcgg caggcacctg atgaccagct ttctgagcat gaagggcctg      960

accgagctga caaacgtggt gggcaactgg agcgacaaga gggcctccgc cgtggccagg     1020

accacctaca cccaccagat caccgccatc cccgaccact acttcgccct ggtgtccagg     1080

tactacgcct acgaccccat cagcaaggag atgatcgccc tgaaggacga gaccaacccc     1140

atcgaggagt ggcagcacat cgagcagctg aagggcagcg ccgagggcag catcagatac     1200

cccgcctgga acggcatcat cagccaggag gtgctggact acctgagcag ctacatcaac     1260

aggcggatct aa                                                         1272


<210>  45
<211>  1041
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cre recobminase

<400>  45
atgaatttac tgaccgtaca ccaaaatttg cctgcattac cggtcgatgc aacgagtgat       60

gaggttcgca agaacctgat ggacatgttc agggatcgcc aggcgttttc tgagcatacc      120

tggaaaatgc ttctgtccgt ttgccggtcg tgggcggcat ggtgcaagtt gaataaccgg      180

aaatggtttc ccgcagaacc tgaagatgtt cgcgattatc ttctatatct tcaggcgcgc      240

ggtctggcag taaaaactat ccagcaacat ttgggccagc taaacatgct tcatcgtcgg      300

tccgggctgc cacgaccaag tgacagcaat gctgtttcac tggttatgcg gcggatccga      360

aaagaaaacg ttgatgccgg tgaacgtgca aaacaggctc tagcgttcga acgcactgat      420

ttcgaccagg ttcgttcact catggaaaat agcgatcgct gccaggatat acgtaatctg      480

gcatttctgg ggattgctta taacaccctg ttacgtatag ccgaaattgc caggatcagg      540

gttaaagata tctcacgtac tgacggtggg agaatgttaa tccatattgg cagaacgaaa      600

acgctggtta gcaccgcagg tgtagagaag gcacttagcc tgggggtaac taaactggtc      660

gagcgatgga tttccgtctc tggtgtagct gatgatccga ataactacct gttttgccgg      720

gtcagaaaaa atggtgttgc cgcgccatct gccaccagcc agctatcaac tcgcgccctg      780

gaagggattt ttgaagcaac tcatcgattg atttacggcg ctaaggatga ctctggtcag      840

agatacctgg cctggtctgg acacagtgcc cgtgtcggag ccgcgcgaga tatggcccgc      900

gctggagttt caataccgga gatcatgcaa gctggtggct ggaccaatgt aaatattgtc      960

atgaactata tccgtaacct ggatagtgaa acaggggcaa tggtgcgcct gctggaagat     1020

ggcgatctcg agccatctta a                                               1041


