                         SEQUENCE LISTING

<110>  The Schepens Eye Research Institute, Inc.
 
<120>  RUNX1 INHIBITION FOR TREATMENT OF PROLIFERATIVE VITREORETINOPATHY
        AND CONDITIONS ASSOCIATED WITH EPITHELIAL TO MESENCHYMAL 
       TRANSITION

<130>  036770-567001WO

<150>  62/586,067
<151>  2017-11-14

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu 
            180                 185                 190         


Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala 
        195                 200                 205             


Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala 
    210                 215                 220                 


Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met 
225                 230                 235                 240 


Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln 
                245                 250                 255     


Ser Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala 
            260                 265                 270         


Thr Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala 
        275                 280                 285             


Glu Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser 
    290                 295                 300                 


Asp Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met 
305                 310                 315                 320 


His Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly 
                325                 330                 335     


Ile Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr 
            340                 345                 350         


Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro 
        355                 360                 365             


Phe Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala 
    370                 375                 380                 


Gly Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg 
385                 390                 395                 400 


Ile Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Ser Ala Leu Leu Asn 
                405                 410                 415     


Pro Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu Gly Ser His 
            420                 425                 430         


Ser Asn Ser Pro Thr Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala 
        435                 440                 445             


Val Trp Arg Pro Tyr 
    450             


<210>  2
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu 
            180                 185                 190         


Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala 
        195                 200                 205             


Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala 
    210                 215                 220                 


Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met 
225                 230                 235                 240 


Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln 
                245                 250                 255     


Ser Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala 
            260                 265                 270         


Thr Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala 
        275                 280                 285             


Glu Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser 
    290                 295                 300                 


Asp Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met 
305                 310                 315                 320 


His Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly 
                325                 330                 335     


Ile Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr 
            340                 345                 350         


Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro 
        355                 360                 365             


Phe Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala 
    370                 375                 380                 


Gly Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg 
385                 390                 395                 400 


Ile Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Ser Ala Leu Leu Asn 
                405                 410                 415     


Pro Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu Gly Ser His 
            420                 425                 430         


Ser Asn Ser Pro Thr Asn Met Gly Gly Ala Ser Cys Ser Arg Gln Ala 
        435                 440                 445             


Arg Arg Asp Pro Gly Pro Trp Ala Arg Thr Pro Ser Trp Gly Arg Gly 
    450                 455                 460                 


Arg Pro Thr Asp Arg Ile Ser Leu 
465                 470         


<210>  3
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu 
            180                 185                 190         


Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala 
        195                 200                 205             


Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala 
    210                 215                 220                 


Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met 
225                 230                 235                 240 


Gln Glu Glu Asp Thr Ala Pro Trp Arg Cys 
                245                 250 


<210>  4
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu 
            180                 185                 190         


Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala 
        195                 200                 205             


Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala 
    210                 215                 220                 


Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met 
225                 230                 235                 240 


Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln 
                245                 250                 255     


Ser 
    


<210>  5
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Ser Lys Cys Ile His Leu Gly Leu Val His Pro Pro Gly Trp Tyr 
            180                 185                 190         


Thr Leu Gln Ala Gly Ile Leu Arg Asp His Val Ser Asp Ser Leu Gly 
        195                 200                 205             


Ser Thr Phe Pro Pro Gly Gly Trp Gln Ala Pro Val Lys Pro Lys Ser 
    210                 215                 220                 


<210>  6
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys 
    130                 135                 140                 


Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala 
145                 150                 155                 160 


Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro 
                165                 170                 175     


Arg Asn Ser Leu Thr Trp Pro Arg Tyr Pro His Ile 
            180                 185             


<210>  7
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Ile Pro Val Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro 
1               5                   10                  15      


Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly 
            20                  25                  30          


Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp 
        35                  40                  45              


Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg 
    50                  55                  60                  


Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg 
65                  70                  75                  80  


Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp 
                85                  90                  95      


Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn 
            100                 105                 110         


Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val 
        115                 120                 125             


Ala Arg Phe Asn Asp Leu Arg Phe Val Asp Gly Pro Arg Glu Pro Arg 
    130                 135                 140                 


Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu Ser 
145                 150                 155                 160 


Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala Met 
                165                 170                 175     


Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala Ser 
            180                 185                 190         


Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met Gln 
        195                 200                 205             


Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln Ser 
    210                 215                 220                 


Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala Thr 
225                 230                 235                 240 


Pro Ile 
        


<210>  8
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ser Asp Ser Ile Phe Glu Ser Phe Pro Ser Tyr Pro Gln Cys 
1               5                   10                  15      


Phe Met Arg Glu Cys Ile Leu Gly Met Asn Pro Ser Arg Asp Val His 
            20                  25                  30          


Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro Ser Thr Ala Leu Ser 
        35                  40                  45              


Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly Ala Pro Asp Ala Gly 
    50                  55                  60                  


Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp Arg Ser Met Val Glu 
65                  70                  75                  80  


Val Leu Ala Asp His Pro Gly Glu Leu Val Arg Thr Asp Ser Pro Asn 
                85                  90                  95      


Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg Cys Asn Lys Thr Leu 
            100                 105                 110         


Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp Val Pro Asp Gly Thr 
        115                 120                 125             


Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn Tyr Ser Ala Glu Leu 
    130                 135                 140                 


Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val Ala Arg Phe Asn Asp 
145                 150                 155                 160 


Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys Ser Phe Thr Leu Thr 
                165                 170                 175     


Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala Thr Tyr His Arg Ala 
            180                 185                 190         


Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro Arg Arg His Arg Gln 
        195                 200                 205             


Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu Ser Phe Ser Glu Arg 
    210                 215                 220                 


Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala Met Arg Val Ser Pro 
225                 230                 235                 240 


His His Pro Ala Pro Thr Pro Asn Pro Arg Ala Ser Leu Asn His Ser 
                245                 250                 255     


Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met Gln Asp Thr Arg Gln 
            260                 265                 270         


Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Gln Tyr Leu 
        275                 280                 285             


Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala Thr Pro Ile Ser Pro 
    290                 295                 300                 


Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala Glu Leu Ser Ser Arg 
305                 310                 315                 320 


Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser Asp Pro Arg Gln Phe 
                325                 330                 335     


Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met His Tyr Pro Gly Ala 
            340                 345                 350         


Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly Ile Gly Ile Gly Met 
        355                 360                 365             


Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr Tyr Leu Pro Pro Pro 
    370                 375                 380                 


Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro Phe Gln Ala Ser Ser 
385                 390                 395                 400 


Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala Gly Ser Tyr Gln Phe 
                405                 410                 415     


Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg Ile Leu Pro Pro Cys 
            420                 425                 430         


Thr Asn Ala Ser Thr Gly Ser Ala Leu Leu Asn Pro Ser Leu Pro Asn 
        435                 440                 445             


Gln Ser Asp Val Val Glu Ala Glu Gly Ser His Ser Asn Ser Pro Thr 
    450                 455                 460                 


Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala Val Trp Arg Pro Tyr 
465                 470                 475                 480 


<210>  9
<211>  456
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asn Pro Ser Arg Asp Val His Asp Ala Ser Thr Ser Arg Arg Phe 
1               5                   10                  15      


Thr Pro Pro Ser Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu 
            20                  25                  30          


Pro Leu Gly Ala Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg 
        35                  40                  45              


Ser Gly Asp Arg Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu 
    50                  55                  60                  


Leu Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr 
65                  70                  75                  80  


His Trp Arg Cys Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala 
                85                  90                  95      


Leu Gly Asp Val Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn 
            100                 105                 110         


Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys 
        115                 120                 125             


Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly 
    130                 135                 140                 


Arg Gly Lys Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro 
145                 150                 155                 160 


Gln Val Ala Thr Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro 
                165                 170                 175     


Arg Glu Pro Arg Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro 
            180                 185                 190         


Gly Ser Leu Ser Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg 
        195                 200                 205             


Arg Thr Ala Met Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn 
    210                 215                 220                 


Pro Arg Ala Ser Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln 
225                 230                 235                 240 


Ser Gln Met Gln Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser 
                245                 250                 255     


Tyr Asp Gln Ser Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val 
            260                 265                 270         


His Pro Ala Thr Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr 
        275                 280                 285             


Leu Ser Ala Glu Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr 
    290                 295                 300                 


Ala Phe Ser Asp Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp 
305                 310                 315                 320 


Pro Arg Met His Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val 
                325                 330                 335     


Thr Ser Gly Ile Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg 
            340                 345                 350         


Tyr His Thr Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln 
        355                 360                 365             


Gly Gly Pro Phe Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly 
    370                 375                 380                 


Ala Ser Ala Gly Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser 
385                 390                 395                 400 


Pro Pro Arg Ile Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Ser Ala 
                405                 410                 415     


Leu Leu Asn Pro Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu 
            420                 425                 430         


Gly Ser His Ser Asn Ser Pro Thr Asn Met Ala Pro Ser Ala Arg Leu 
        435                 440                 445             


Glu Glu Ala Val Trp Arg Pro Tyr 
    450                 455     


<210>  10
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Pro Ala Ala Pro Arg Gly Pro Ala Gln Gly Glu Ala Ala Ala Arg 
1               5                   10                  15      


Thr Arg Ser Arg Asp Ala Ser Thr Ser Arg Arg Phe Thr Pro Pro Ser 
            20                  25                  30          


Thr Ala Leu Ser Pro Gly Lys Met Ser Glu Ala Leu Pro Leu Gly Ala 
        35                  40                  45              


Pro Asp Ala Gly Ala Ala Leu Ala Gly Lys Leu Arg Ser Gly Asp Arg 
    50                  55                  60                  


Ser Met Val Glu Val Leu Ala Asp His Pro Gly Glu Leu Val Arg Thr 
65                  70                  75                  80  


Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Thr His Trp Arg Cys 
                85                  90                  95      


Asn Lys Thr Leu Pro Ile Ala Phe Lys Val Val Ala Leu Gly Asp Val 
            100                 105                 110         


Pro Asp Gly Thr Leu Val Thr Val Met Ala Gly Asn Asp Glu Asn Tyr 
        115                 120                 125             


Ser Ala Glu Leu Arg Asn Ala Thr Ala Ala Met Lys Asn Gln Val Ala 
    130                 135                 140                 


Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys Ser 
145                 150                 155                 160 


Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala Thr 
                165                 170                 175     


Tyr His Arg Ala Ile Lys Ile Thr Val Asp Gly Pro Arg Glu Pro Arg 
            180                 185                 190         


Arg His Arg Gln Lys Leu Asp Asp Gln Thr Lys Pro Gly Ser Leu Ser 
        195                 200                 205             


Phe Ser Glu Arg Leu Ser Glu Leu Glu Gln Leu Arg Arg Thr Ala Met 
    210                 215                 220                 


Arg Val Ser Pro His His Pro Ala Pro Thr Pro Asn Pro Arg Ala Ser 
225                 230                 235                 240 


Leu Asn His Ser Thr Ala Phe Asn Pro Gln Pro Gln Ser Gln Met Gln 
                245                 250                 255     


Asp Thr Arg Gln Ile Gln Pro Ser Pro Pro Trp Ser Tyr Asp Gln Ser 
            260                 265                 270         


Tyr Gln Tyr Leu Gly Ser Ile Ala Ser Pro Ser Val His Pro Ala Thr 
        275                 280                 285             


Pro Ile Ser Pro Gly Arg Ala Ser Gly Met Thr Thr Leu Ser Ala Glu 
    290                 295                 300                 


Leu Ser Ser Arg Leu Ser Thr Ala Pro Asp Leu Thr Ala Phe Ser Asp 
305                 310                 315                 320 


Pro Arg Gln Phe Pro Ala Leu Pro Ser Ile Ser Asp Pro Arg Met His 
                325                 330                 335     


Tyr Pro Gly Ala Phe Thr Tyr Ser Pro Thr Pro Val Thr Ser Gly Ile 
            340                 345                 350         


Gly Ile Gly Met Ser Ala Met Gly Ser Ala Thr Arg Tyr His Thr Tyr 
        355                 360                 365             


Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ala Gln Gly Gly Pro Phe 
    370                 375                 380                 


Gln Ala Ser Ser Pro Ser Tyr His Leu Tyr Tyr Gly Ala Ser Ala Gly 
385                 390                 395                 400 


Ser Tyr Gln Phe Ser Met Val Gly Gly Glu Arg Ser Pro Pro Arg Ile 
                405                 410                 415     


Leu Pro Pro Cys Thr Asn Ala Ser Thr Gly Ser Ala Leu Leu Asn Pro 
            420                 425                 430         


Ser Leu Pro Asn Gln Ser Asp Val Val Glu Ala Glu Gly Ser His Ser 
        435                 440                 445             


Asn Ser Pro Thr Asn Met Ala Pro Ser Ala Arg Leu Glu Glu Ala Val 
    450                 455                 460                 


Trp Arg Pro Tyr 
465             


<210>  11
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Gly Asn Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Thr 
1               5                   10                  15      


Ala Ala Met Lys Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val 
            20                  25                  30          


Gly Arg Ser Gly Arg Gly Lys Ser Phe Thr Leu Thr Ile Thr Val Phe 
        35                  40                  45              


Thr Asn Pro Pro Gln Val Ala Thr Tyr His Arg Ala Ile Lys Ile Thr 
    50                  55                  60                  


Val Asp Gly Pro Arg Glu Pro Arg Arg His Arg Gln Lys Leu Asp Asp 
65                  70                  75                  80  


Gln Thr Lys Pro Gly Ser Leu Ser Phe Ser Glu Arg Leu Ser Glu Leu 
                85                  90                  95      


Glu Gln Leu Arg Arg Thr Ala Met Arg Val Ser Pro His His Pro Ala 
            100                 105                 110         


Pro Thr Pro Asn Pro Arg Ala Ser Leu Asn His Ser Thr Ala Phe Asn 
        115                 120                 125             


Pro Gln Pro Gln Ser Gln Met Gln Asp Thr Arg Gln Ile Gln Pro Ser 
    130                 135                 140                 


Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Gln Tyr Leu Gly Ser Ile Ala 
145                 150                 155                 160 


Ser Pro Ser Val His Pro Ala Thr Pro Ile Ser Pro Gly Arg Ala Ser 
                165                 170                 175     


Gly Met Thr Thr Leu Ser Ala Glu Leu Ser Ser Arg Leu Ser Thr Ala 
            180                 185                 190         


Pro Asp Leu Thr Ala Phe Ser Asp Pro Arg Gln Phe Pro Ala Leu Pro 
        195                 200                 205             


Ser Ile Ser Asp Pro Arg Met His Tyr Pro Gly Ala Phe Thr Tyr Ser 
    210                 215                 220                 


Pro Thr Pro Val Thr Ser Gly Ile Gly Ile Gly Met Ser Ala Met Gly 
225                 230                 235                 240 


Ser Ala Thr Arg Tyr His Thr Tyr Leu Pro Pro Pro Tyr Pro Gly Ser 
                245                 250                 255     


Ser Gln Ala Gln Gly Gly Pro Phe Gln Ala Ser Ser Pro Ser Tyr His 
            260                 265                 270         


Leu Tyr Tyr Gly Ala Ser Ala Gly Ser Tyr Gln Phe Ser Met Val Gly 
        275                 280                 285             


Gly Glu Arg Ser Pro Pro Arg Ile Leu Pro Pro Cys Thr Asn Ala Ser 
    290                 295                 300                 


Thr Gly Ser Ala Leu Leu Asn Pro Ser Leu Pro Asn Gln Ser Asp Val 
305                 310                 315                 320 


Val Glu Ala Glu Gly Ser His Ser Asn Ser Pro Thr Asn Met Ala Pro 
                325                 330                 335     


Ser Ala Arg Leu Glu Glu Ala Val Trp Arg Pro Tyr 
            340                 345             


<210>  12
<211>  7274
<212>  DNA
<213>  Homo sapiens

<400>  12
catagagcca gcgggcgcgg gcgggacggg cgccccgcgg ccggacccag ccagggcacc       60

acgctgcccg gccctgcgcc gccaggcact tctttccggg gctcctaggg acgccagaag      120

gaagtcaacc tctgctgctt ctccttggcc tgcgttggac cttccttttt ttgttgtttt      180

tttttgtttt tcccctttct tccttttgaa ttaactggct tcttggctgg atgttttcaa      240

cttctttcct ggctgcgaac ttttccccaa ttgttttcct tttacaacag ggggagaaag      300

tgctctgtgg tccgaggcga gccgtgaagt tgcgtgtgcg tggcagtgtg cgtggcagga      360

tgtgcgtgcg tgtgtaaccc gagccgcccg atctgtttcg atctgcgccg cggagccctc      420

cctcaaggcc cgctccacct gctgcggtta cgcggcgctc gtgggtgttc gtgcctcgga      480

gcagctaacc ggcgggtgct gggcgacggt ggaggagtat cgtctcgctg ctgcccgagt      540

cagggctgag tcacccagct gatgtagaca gtggctgcct tccgaagagt gcgtgtttgc      600

atgtgtgtga ctctgcggct gctcaactcc caacaaacca gaggaccagc cacaaactta      660

accaacatcc ccaaacccga gttcacagat gtgggagagc tgtagaaccc tgagtgtcat      720

cgactgggcc ttcttatgat tgttgtttta agattagctg aagatctctg aaacgctgaa      780

ttttctgcac tgagcgtttt gacagaattc attgagagaa cagagaacat gacaagtact      840

tctagctcag cactgctcca actactgaag ctgattttca aggctactta aaaaaatctg      900

cagcgtacat taatggattt ctgttgtgtt taaattctcc acagattgta ttgtaaatat      960

tttatgaagt agagcatatg tatatattta tatatacgtg cacatacatt agtagcacta     1020

cctttggaag tctcagctct tgcttttcgg gactgaagcc agttttgcat gataaaagtg     1080

gccttgttac gggagataat tgtgttctgt tgggacttta gacaaaactc acctgcaaaa     1140

aactgacagg cattaactac tggaacttcc aaataatgtg tttgctgatc gttttactct     1200

tcgcataaat attttaggaa gtgtatgaga attttgcctt caggaacttt tctaacagcc     1260

aaagacagaa cttaacctct gcaagcaaga ttcgtggaag atagtctcca ctttttaatg     1320

cactaagcaa tcggttgcta ggagcccatc ctgggtcaga ggccgatccg cagaaccaga     1380

acgttttccc ctcctggact gttagtaact tagtctccct cctcccctaa ccacccccgc     1440

ccccccccac cccccgcagt aataaaggcc cctgaacgtg tatgttggtc tcccgggagc     1500

tgcttgctga agatccgcgc ccctgtcgcc gtctggtagg agctgtttgc agggtcctaa     1560

ctcaatcggc ttgttgtgat gcgtatcccc gtagatgcca gcacgagccg ccgcttcacg     1620

ccgccttcca ccgcgctgag cccaggcaag atgagcgagg cgttgccgct gggcgccccg     1680

gacgccggcg ctgccctggc cggcaagctg aggagcggcg accgcagcat ggtggaggtg     1740

ctggccgacc acccgggcga gctggtgcgc accgacagcc ccaacttcct ctgctccgtg     1800

ctgcctacgc actggcgctg caacaagacc ctgcccatcg ctttcaaggt ggtggcccta     1860

ggggatgttc cagatggcac tctggtcact gtgatggctg gcaatgatga aaactactcg     1920

gctgagctga gaaatgctac cgcagccatg aagaaccagg ttgcaagatt taatgacctc     1980

aggtttgtcg gtcgaagtgg aagagggaaa agcttcactc tgaccatcac tgtcttcaca     2040

aacccaccgc aagtcgccac ctaccacaga gccatcaaaa tcacagtgga tgggccccga     2100

gaacctcgaa gacatcggca gaaactagat gatcagacca agcccgggag cttgtccttt     2160

tccgagcggc tcagtgaact ggagcagctg cggcgcacag ccatgagggt cagcccacac     2220

cacccagccc ccacgcccaa ccctcgtgcc tccctgaacc actccactgc ctttaaccct     2280

cagcctcaga gtcagatgca ggatacaagg cagatccaac catccccacc gtggtcctac     2340

gatcagtcct accaatacct gggatccatt gcctctcctt ctgtgcaccc agcaacgccc     2400

atttcacctg gacgtgccag cggcatgaca accctctctg cagaactttc cagtcgactc     2460

tcaacggcac ccgacctgac agcgttcagc gacccgcgcc agttccccgc gctgccctcc     2520

atctccgacc cccgcatgca ctatccaggc gccttcacct actccccgac gccggtcacc     2580

tcgggcatcg gcatcggcat gtcggccatg ggctcggcca cgcgctacca cacctacctg     2640

ccgccgccct accccggctc gtcgcaagcg cagggaggcc cgttccaagc cagctcgccc     2700

tcctaccacc tgtactacgg cgcctcggcc ggctcctacc agttctccat ggtgggcggc     2760

gagcgctcgc cgccgcgcat cctgccgccc tgcaccaacg cctccaccgg ctccgcgctg     2820

ctcaacccca gcctcccgaa ccagagcgac gtggtggagg ccgagggcag ccacagcaac     2880

tcccccacca acatggcgcc ctccgcgcgc ctggaggagg ccgtgtggag gccctactga     2940

ggcgccaggc ctggcccggc tgggccccgc gggccgccgc cttcgcctcc gggcgcgcgg     3000

gcctcctgtt cgcgacaagc ccgccgggat cccgggccct gggcccggcc accgtcctgg     3060

ggccgagggc gcccgacggc caggatctcg ctgtaggtca ggcccgcgca gcctcctgcg     3120

cccagaagcc cacgccgccg ccgtctgctg gcgccccggc cctcgcggag gtgtccgagg     3180

cgacgcacct cgagggtgtc cgccggcccc agcacccagg ggacgcgctg gaaagcaaac     3240

aggaagattc ccggagggaa actgtgaatg cttctgattt agcaatgctg tgaataaaaa     3300

gaaagatttt atacccttga cttaactttt taaccaagtt gtttattcca aagagtgtgg     3360

aattttggtt ggggtggggg gagaggaggg atgcaactcg ccctgtttgg catctaattc     3420

ttatttttaa tttttccgca ccttatcaat tgcaaaatgc gtatttgcat ttgggtggtt     3480

tttattttta tatacgttta tataaatata tataaattga gcttgcttct ttcttgcttt     3540

gaccatggaa agaaatatga ttcccttttc tttaagtttt atttaacttt tcttttggac     3600

ttttgggtag ttgttttttt ttgttttgtt ttgttttttt gagaaacagc tacagctttg     3660

ggtcattttt aactactgta ttcccacaag gaatccccag atatttatgt atcttgatgt     3720

tcagacattt atgtgttgat aattttttaa ttatttaaat gtacttatat taagaaaaat     3780

atcaagtact acattttctt ttgttcttga tagtagccaa agttaaatgt atcacattga     3840

agaaggctag aaaaaaagaa tgagtaatgt gatcgcttgg ttatccagaa gtattgttta     3900

cattaaactc cctttcatgt taatcaaaca agtgagtagc tcacgcagca acgtttttaa     3960

taggattttt agacactgag ggtcactcca aggatcagaa gtatggaatt ttctgccagg     4020

ctcaacaagg gtctcatatc taacttcctc cttaaaacag agaaggtcaa tctagttcca     4080

gagggttgag gcaggtgcca ataattacat ctttggagag gatttgattt ctgcccaggg     4140

atttgctcac cccaaggtca tctgataatt tcacagatgc tgtgtaacag aacacagcca     4200

aagtaaactg tgtaggggag ccacatttac ataggaacca aatcaatgaa tttaggggtt     4260

acgattatag caatttaagg gcccaccaga agcaggcctc gaggagtcaa tttgcctctg     4320

tgtgcctcag tggagacaag tgggaaaaca tggtcccacc tgtgcgagac cccctgtcct     4380

gtgctgctca ctcaacaaca tctttgtgtt gctttcacca ggctgagacc ctaccctatg     4440

gggtatatgg gcttttacct gtgcaccagt gtgacaggaa agattcatgt cactactgtc     4500

cgtggctaca attcaaaggt atccaatgtc gctgtaaatt ttatggcact atttttattg     4560

gaggatttgg tcagaatgca gttgttgtac aactcataaa tactaactgc tgattttgac     4620

acatgtgtgc tccaaatgat ctggtggtta tttaacgtac ctcttaaaat tcgttgaaac     4680

gatttcaggt caactctgaa gagtatttga aagcaggact tcagaacagt gtttgatttt     4740

tattttataa atttaagcat tcaaattagg caaatctttg gctgcaggca gcaaaaacag     4800

ctggacttat ttaaaacaac ttgtttttga gttttcttat atatatattg attatttgtt     4860

ttacacacat gcagtagcac tttggtaaga gttaaagagt aaagcagctt atgttgtcag     4920

gtcgttctta tctagagaag agctatagca gatctcggac aaactcagaa tatattcact     4980

ttcatttttg acaggattcc ctccacaact cagtttcata tattattccg tattacattt     5040

ttgcagctaa attaccataa aatgtcagca aatgtaaaaa tttaatttct gaaaagcacc     5100

attagcccat ttcccccaaa ttaaacgtaa atgttttttt tcagcacatg ttaccatgtc     5160

tgacctgcaa aaatgctgga gaaaaatgaa ggaaaaaatt atgtttttca gtttaattct     5220

gttaactgaa gatattccaa ctcaaaacca gcctcatgct ctgattagat aatcttttac     5280

attgaacctt tactctcaaa gccatgtgtg gagggggctt gtcactattg taggctcact     5340

ggattggtca tttagagttt cacagactct taccagcata tatagtattt aattgtttca     5400

aaaaaaatca aactgtagtt gttttggcga taggtctcac gcaacacatt tttgtatgtg     5460

tgtgtgtgtg cgtgtgtgtg tgtgtgtgtg aaaaattgca ttcattgact tcaggtagat     5520

taaggtatct ttttattcat tgccctcagg aaagttaagg tatcaatgag acccttaagc     5580

caatcatgta ataactgcat gtgtctggtc caggagaagt attgaataag ccatttctac     5640

tgcttactca tgtccctatt tatgatttca acatggatac atatttcagt tctttctttt     5700

tctcactatc tgaaaataca tttccctccc tctcttcccc ccaatatctc cctttttttc     5760

tctcttcctc tatcttccaa accccacttt ctccctcctc cttttcctgt gttctcttaa     5820

gcagatagca cataccccca cccagtacca aatttcagaa cacaagaagg tccagttctt     5880

cccccttcac ataaaggaac atggtttgtc agcctttctc ctgtttatgg gtttcttcca     5940

gcagaacaga gacattgcca accatattgg atctgcttgc tgtccaaacc agcaaacttt     6000

cctgggcaaa tcacaatcag tgagtaaata gacagccttt ctgctgcctt gggtttctgt     6060

gcagataaac agaaatgctc tgattagaaa ggaaatgaat ggttccactc aaatgtcctg     6120

caatttagga ttgcagattt ctgccttgaa atacctgttt ctttgggaca ttccgtcctg     6180

atgattttta tttttgttgg tttttatttt tggggggaat gacatgtttg ggtcttttat     6240

acatgaaaat ttgtttgaca ataatctcac aaaacatatt ttacatctga acaaaatgcc     6300

tttttgttta ccgtagcgta tacatttgtt ttgggatttt tgtgtgtttg ttgggaattt     6360

tgtttttagc caggtcagta ttgatgaggc tgatcatttg gctctttttt tccttccaga     6420

agagttgcat caacaaagtt aattgtattt atgtatgtaa atagatttta agcttcatta     6480

taaaatattg ttaatgccta taactttttt tcaatttttt tgtgtgtgtt tctaaggact     6540

ttttcttagg tttgctaaat actgtaggga aaaaaatgct tctttctact ttgtttattt     6600

tagactttaa aatgagctac ttcttattca cttttgtaaa cagctaatag catggttcca     6660

atttttttta agttcacttt ttttgttcta ggggaaatga atgtgcaaaa aaagaaaaag     6720

aactgttggt tatttgtgtt attctggatg tataaaaatc aatggaaaaa aataaacttt     6780

caaattgaaa tgacggtata acacatctac tgaaaaagca acgggaaatg tggtcctatt     6840

taagccagcc cccacctagg gtctatttgt gtggcagtta ttgggtttgg tcacaaaaca     6900

tcctgaaaat tcgtgcgtgg gcttctttct ccctggtaca aacgtatgga atgcttctta     6960

aaggggaact gtcaagctgg tgtcttcagc cagatgacat gagagaatat cccagaaccc     7020

tctctccaag gtgtttctag atagcacagg agagcaggca ctgcactgtc cacagtccac     7080

ggtacacagt cgggtgggcc gcctcccctc tcctgggagc attcgtcgtg cccagcctga     7140

gcagggcagc tggactgctg ctgttcagga gccaccagag ccttcctctc tttgtaccac     7200

agtttcttct gtaaatccag tgttacaatc agtgtgaatg gcaaataaac agtttgacaa     7260

gtacatacac cata                                                       7274


<210>  13
<211>  5967
<212>  DNA
<213>  Homo sapiens

<400>  13
ctttgggcct cataaacaac cacagaacca caagttgggt agcctggcag tgtcagaagt       60

ctgaacccag catagtggtc agcaggcagg acgaatcaca ctgaatgcaa accacagggt      120

ttcgcagcgt ggtaaaagaa atcattgagt cccccgcctt cagaagaggg tgcattttca      180

ggaggaagcg atggcttcag acagcatatt tgagtcattt ccttcgtacc cacagtgctt      240

catgagagaa tgcatacttg gaatgaatcc ttctagagac gtccacgatg ccagcacgag      300

ccgccgcttc acgccgcctt ccaccgcgct gagcccaggc aagatgagcg aggcgttgcc      360

gctgggcgcc ccggacgccg gcgctgccct ggccggcaag ctgaggagcg gcgaccgcag      420

catggtggag gtgctggccg accacccggg cgagctggtg cgcaccgaca gccccaactt      480

cctctgctcc gtgctgccta cgcactggcg ctgcaacaag accctgccca tcgctttcaa      540

ggtggtggcc ctaggggatg ttccagatgg cactctggtc actgtgatgg ctggcaatga      600

tgaaaactac tcggctgagc tgagaaatgc taccgcagcc atgaagaacc aggttgcaag      660

atttaatgac ctcaggtttg tcggtcgaag tggaagaggg aaaagcttca ctctgaccat      720

cactgtcttc acaaacccac cgcaagtcgc cacctaccac agagccatca aaatcacagt      780

ggatgggccc cgagaacctc gaagacatcg gcagaaacta gatgatcaga ccaagcccgg      840

gagcttgtcc ttttccgagc ggctcagtga actggagcag ctgcggcgca cagccatgag      900

ggtcagccca caccacccag cccccacgcc caaccctcgt gcctccctga accactccac      960

tgcctttaac cctcagcctc agagtcagat gcaggataca aggcagatcc aaccatcccc     1020

accgtggtcc tacgatcagt cctaccaata cctgggatcc attgcctctc cttctgtgca     1080

cccagcaacg cccatttcac ctggacgtgc cagcggcatg acaaccctct ctgcagaact     1140

ttccagtcga ctctcaacgg cacccgacct gacagcgttc agcgacccgc gccagttccc     1200

cgcgctgccc tccatctccg acccccgcat gcactatcca ggcgccttca cctactcccc     1260

gacgccggtc acctcgggca tcggcatcgg catgtcggcc atgggctcgg ccacgcgcta     1320

ccacacctac ctgccgccgc cctaccccgg ctcgtcgcaa gcgcagggag gcccgttcca     1380

agccagctcg ccctcctacc acctgtacta cggcgcctcg gccggctcct accagttctc     1440

catggtgggc ggcgagcgct cgccgccgcg catcctgccg ccctgcacca acgcctccac     1500

cggctccgcg ctgctcaacc ccagcctccc gaaccagagc gacgtggtgg aggccgaggg     1560

cagccacagc aactccccca ccaacatggc gccctccgcg cgcctggagg aggccgtgtg     1620

gaggccctac tgaggcgcca ggcctggccc ggctgggccc cgcgggccgc cgccttcgcc     1680

tccgggcgcg cgggcctcct gttcgcgaca agcccgccgg gatcccgggc cctgggcccg     1740

gccaccgtcc tggggccgag ggcgcccgac ggccaggatc tcgctgtagg tcaggcccgc     1800

gcagcctcct gcgcccagaa gcccacgccg ccgccgtctg ctggcgcccc ggccctcgcg     1860

gaggtgtccg aggcgacgca cctcgagggt gtccgccggc cccagcaccc aggggacgcg     1920

ctggaaagca aacaggaaga ttcccggagg gaaactgtga atgcttctga tttagcaatg     1980

ctgtgaataa aaagaaagat tttataccct tgacttaact ttttaaccaa gttgtttatt     2040

ccaaagagtg tggaattttg gttggggtgg ggggagagga gggatgcaac tcgccctgtt     2100

tggcatctaa ttcttatttt taatttttcc gcaccttatc aattgcaaaa tgcgtatttg     2160

catttgggtg gtttttattt ttatatacgt ttatataaat atatataaat tgagcttgct     2220

tctttcttgc tttgaccatg gaaagaaata tgattccctt ttctttaagt tttatttaac     2280

ttttcttttg gacttttggg tagttgtttt tttttgtttt gttttgtttt tttgagaaac     2340

agctacagct ttgggtcatt tttaactact gtattcccac aaggaatccc cagatattta     2400

tgtatcttga tgttcagaca tttatgtgtt gataattttt taattattta aatgtactta     2460

tattaagaaa aatatcaagt actacatttt cttttgttct tgatagtagc caaagttaaa     2520

tgtatcacat tgaagaaggc tagaaaaaaa gaatgagtaa tgtgatcgct tggttatcca     2580

gaagtattgt ttacattaaa ctccctttca tgttaatcaa acaagtgagt agctcacgca     2640

gcaacgtttt taataggatt tttagacact gagggtcact ccaaggatca gaagtatgga     2700

attttctgcc aggctcaaca agggtctcat atctaacttc ctccttaaaa cagagaaggt     2760

caatctagtt ccagagggtt gaggcaggtg ccaataatta catctttgga gaggatttga     2820

tttctgccca gggatttgct caccccaagg tcatctgata atttcacaga tgctgtgtaa     2880

cagaacacag ccaaagtaaa ctgtgtaggg gagccacatt tacataggaa ccaaatcaat     2940

gaatttaggg gttacgatta tagcaattta agggcccacc agaagcaggc ctcgaggagt     3000

caatttgcct ctgtgtgcct cagtggagac aagtgggaaa acatggtccc acctgtgcga     3060

gaccccctgt cctgtgctgc tcactcaaca acatctttgt gttgctttca ccaggctgag     3120

accctaccct atggggtata tgggctttta cctgtgcacc agtgtgacag gaaagattca     3180

tgtcactact gtccgtggct acaattcaaa ggtatccaat gtcgctgtaa attttatggc     3240

actattttta ttggaggatt tggtcagaat gcagttgttg tacaactcat aaatactaac     3300

tgctgatttt gacacatgtg tgctccaaat gatctggtgg ttatttaacg tacctcttaa     3360

aattcgttga aacgatttca ggtcaactct gaagagtatt tgaaagcagg acttcagaac     3420

agtgtttgat ttttatttta taaatttaag cattcaaatt aggcaaatct ttggctgcag     3480

gcagcaaaaa cagctggact tatttaaaac aacttgtttt tgagttttct tatatatata     3540

ttgattattt gttttacaca catgcagtag cactttggta agagttaaag agtaaagcag     3600

cttatgttgt caggtcgttc ttatctagag aagagctata gcagatctcg gacaaactca     3660

gaatatattc actttcattt ttgacaggat tccctccaca actcagtttc atatattatt     3720

ccgtattaca tttttgcagc taaattacca taaaatgtca gcaaatgtaa aaatttaatt     3780

tctgaaaagc accattagcc catttccccc aaattaaacg taaatgtttt ttttcagcac     3840

atgttaccat gtctgacctg caaaaatgct ggagaaaaat gaaggaaaaa attatgtttt     3900

tcagtttaat tctgttaact gaagatattc caactcaaaa ccagcctcat gctctgatta     3960

gataatcttt tacattgaac ctttactctc aaagccatgt gtggaggggg cttgtcacta     4020

ttgtaggctc actggattgg tcatttagag tttcacagac tcttaccagc atatatagta     4080

tttaattgtt tcaaaaaaaa tcaaactgta gttgttttgg cgataggtct cacgcaacac     4140

atttttgtat gtgtgtgtgt gtgcgtgtgt gtgtgtgtgt gtgaaaaatt gcattcattg     4200

acttcaggta gattaaggta tctttttatt cattgccctc aggaaagtta aggtatcaat     4260

gagaccctta agccaatcat gtaataactg catgtgtctg gtccaggaga agtattgaat     4320

aagccatttc tactgcttac tcatgtccct atttatgatt tcaacatgga tacatatttc     4380

agttctttct ttttctcact atctgaaaat acatttccct ccctctcttc cccccaatat     4440

ctcccttttt ttctctcttc ctctatcttc caaaccccac tttctccctc ctccttttcc     4500

tgtgttctct taagcagata gcacataccc ccacccagta ccaaatttca gaacacaaga     4560

aggtccagtt cttccccctt cacataaagg aacatggttt gtcagccttt ctcctgttta     4620

tgggtttctt ccagcagaac agagacattg ccaaccatat tggatctgct tgctgtccaa     4680

accagcaaac tttcctgggc aaatcacaat cagtgagtaa atagacagcc tttctgctgc     4740

cttgggtttc tgtgcagata aacagaaatg ctctgattag aaaggaaatg aatggttcca     4800

ctcaaatgtc ctgcaattta ggattgcaga tttctgcctt gaaatacctg tttctttggg     4860

acattccgtc ctgatgattt ttatttttgt tggtttttat ttttgggggg aatgacatgt     4920

ttgggtcttt tatacatgaa aatttgtttg acaataatct cacaaaacat attttacatc     4980

tgaacaaaat gcctttttgt ttaccgtagc gtatacattt gttttgggat ttttgtgtgt     5040

ttgttgggaa ttttgttttt agccaggtca gtattgatga ggctgatcat ttggctcttt     5100

ttttccttcc agaagagttg catcaacaaa gttaattgta tttatgtatg taaatagatt     5160

ttaagcttca ttataaaata ttgttaatgc ctataacttt ttttcaattt ttttgtgtgt     5220

gtttctaagg actttttctt aggtttgcta aatactgtag ggaaaaaaat gcttctttct     5280

actttgttta ttttagactt taaaatgagc tacttcttat tcacttttgt aaacagctaa     5340

tagcatggtt ccaatttttt ttaagttcac tttttttgtt ctaggggaaa tgaatgtgca     5400

aaaaaagaaa aagaactgtt ggttatttgt gttattctgg atgtataaaa atcaatggaa     5460

aaaaataaac tttcaaattg aaatgacggt ataacacatc tactgaaaaa gcaacgggaa     5520

atgtggtcct atttaagcca gcccccacct agggtctatt tgtgtggcag ttattgggtt     5580

tggtcacaaa acatcctgaa aattcgtgcg tgggcttctt tctccctggt acaaacgtat     5640

ggaatgcttc ttaaagggga actgtcaagc tggtgtcttc agccagatga catgagagaa     5700

tatcccagaa ccctctctcc aaggtgtttc tagatagcac aggagagcag gcactgcact     5760

gtccacagtc cacggtacac agtcgggtgg gccgcctccc ctctcctggg agcattcgtc     5820

gtgcccagcc tgagcagggc agctggactg ctgctgttca ggagccacca gagccttcct     5880

ctctttgtac cacagtttct tctgtaaatc cagtgttaca atcagtgtga atggcaaata     5940

aacagtttga caagtacata caccata                                         5967


<210>  14
<211>  2722
<212>  DNA
<213>  Homo sapiens

<400>  14
catagagcca gcgggcgcgg gcgggacggg cgccccgcgg ccggacccag ccagggcacc       60

acgctgcccg gccctgcgcc gccaggcact tctttccggg gctcctaggg acgccagaag      120

gaagtcaacc tctgctgctt ctccttggcc tgcgttggac cttccttttt ttgttgtttt      180

tttttgtttt tcccctttct tccttttgaa ttaactggct tcttggctgg atgttttcaa      240

cttctttcct ggctgcgaac ttttccccaa ttgttttcct tttacaacag ggggagaaag      300

tgctctgtgg tccgaggcga gccgtgaagt tgcgtgtgcg tggcagtgtg cgtggcagga      360

tgtgcgtgcg tgtgtaaccc gagccgcccg atctgtttcg atctgcgccg cggagccctc      420

cctcaaggcc cgctccacct gctgcggtta cgcggcgctc gtgggtgttc gtgcctcgga      480

gcagctaacc ggcgggtgct gggcgacggt ggaggagtat cgtctcgctg ctgcccgagt      540

cagggctgag tcacccagct gatgtagaca gtggctgcct tccgaagagt gcgtgtttgc      600

atgtgtgtga ctctgcggct gctcaactcc caacaaacca gaggaccagc cacaaactta      660

accaacatcc ccaaacccga gttcacagat gtgggagagc tgtagaaccc tgagtgtcat      720

cgactgggcc ttcttatgat tgttgtttta agattagctg aagatctctg aaacgctgaa      780

ttttctgcac tgagcgtttt gacagaattc attgagagaa cagagaacat gacaagtact      840

tctagctcag cactgctcca actactgaag ctgattttca aggctactta aaaaaatctg      900

cagcgtacat taatggattt ctgttgtgtt taaattctcc acagattgta ttgtaaatat      960

tttatgaagt agagcatatg tatatattta tatatacgtg cacatacatt agtagcacta     1020

cctttggaag tctcagctct tgcttttcgg gactgaagcc agttttgcat gataaaagtg     1080

gccttgttac gggagataat tgtgttctgt tgggacttta gacaaaactc acctgcaaaa     1140

aactgacagg cattaactac tggaacttcc aaataatgtg tttgctgatc gttttactct     1200

tcgcataaat attttaggaa gtgtatgaga attttgcctt caggaacttt tctaacagcc     1260

aaagacagaa cttaacctct gcaagcaaga ttcgtggaag atagtctcca ctttttaatg     1320

cactaagcaa tcggttgcta ggagcccatc ctgggtcaga ggccgatccg cagaaccaga     1380

acgttttccc ctcctggact gttagtaact tagtctccct cctcccctaa ccacccccgc     1440

ccccccccac cccccgcagt aataaaggcc cctgaacgtg tatgttggtc tcccgggagc     1500

tgcttgctga agatccgcgc ccctgtcgcc gtctggtagg agctgtttgc agggtcctaa     1560

ctcaatcggc ttgttgtgat gcgtatcccc gtagatgcca gcacgagccg ccgcttcacg     1620

ccgccttcca ccgcgctgag cccaggcaag atgagcgagg cgttgccgct gggcgccccg     1680

gacgccggcg ctgccctggc cggcaagctg aggagcggcg accgcagcat ggtggaggtg     1740

ctggccgacc acccgggcga gctggtgcgc accgacagcc ccaacttcct ctgctccgtg     1800

ctgcctacgc actggcgctg caacaagacc ctgcccatcg ctttcaaggt ggtggcccta     1860

ggggatgttc cagatggcac tctggtcact gtgatggctg gcaatgatga aaactactcg     1920

gctgagctga gaaatgctac cgcagccatg aagaaccagg ttgcaagatt taatgacctc     1980

aggtttgtcg gtcgaagtgg aagagggaaa agcttcactc tgaccatcac tgtcttcaca     2040

aacccaccgc aagtcgccac ctaccacaga gccatcaaaa tcacagtgga tgggccccga     2100

gaacctcgaa gacatcggca gaaactagat gatcagacca agcccgggag cttgtccttt     2160

tccgagcggc tcagtgaact ggagcagctg cggcgcacag ccatgagggt cagcccacac     2220

cacccagccc ccacgcccaa ccctcgtgcc tccctgaacc actccactgc ctttaaccct     2280

cagcctcaga gtcagatgca ggaggaagac acagcaccct ggagatgtta aggcagaagt     2340

cagttcttct gtccatccct ctccccagcc aggatagagc tatcttttcc atctcatcct     2400

cagaagagac tcagaagaaa gatgacagcc ctcagaatgc acgttatgag gaaggcagaa     2460

tgtgggtctg taattcctcc gtgtcccttc tccccctctg caaaccgtcg taacaataat     2520

agttcctaac acatgggaca attgtgagga ttaaatgagt tagcctgcag aaatcacttg     2580

atgcacagca catgggaagc attgtgtgta tttattaatc cttcacaaag tctttgagat     2640

atatttttat caaatattta gcatggatcc cggtacactt tcaatactta ataaatggtc     2700

aatgttattc tttttcacta tt                                              2722


<210>  15
<211>  6230
<212>  DNA
<213>  Homo sapiens

<400>  15
agggcggctg ctgccccctg gcgtccgcca gagcccgcgg cgcgtcccga cagctccgcg       60

cagtccgggc ccgcccggga aaggcctcca cgccagtcaa ccccggcccc ctcctgcgtc      120

cgggcccgcg gcaacgcccg gggacagtcc ctgcgcggca gcggccacag caccctagcc      180

ctgggggagg gaggagcggg cgtcaggggc cccgtgaggt cggcgaggga cccccgcgcc      240

ggggagctta attgaggggc tccgcgggga ccacaaagca gcccgcggtg gaacggggcc      300

gggatccggg gactgggttg cagccccggg gtggatgaga ggccccggga ggtgcagggc      360

ccggcaggga gggcgtggag ggactcatgg tgacgggagc agcctccgct gggagggagc      420

cccgccgggc ggggtcggag ttggcagcgc acgccggacc gggggcgggg ccctccgagc      480

tccgcgaaaa tgcccgcagc accgcgggga ccggcgcagg gggaagcggc cgcccgcacg      540

cgaagccggg atgccagcac gagccgccgc ttcacgccgc cttccaccgc gctgagccca      600

ggcaagatga gcgaggcgtt gccgctgggc gccccggacg ccggcgctgc cctggccggc      660

aagctgagga gcggcgaccg cagcatggtg gaggtgctgg ccgaccaccc gggcgagctg      720

gtgcgcaccg acagccccaa cttcctctgc tccgtgctgc ctacgcactg gcgctgcaac      780

aagaccctgc ccatcgcttt caaggtggtg gccctagggg atgttccaga tggcactctg      840

gtcactgtga tggctggcaa tgatgaaaac tactcggctg agctgagaaa tgctaccgca      900

gccatgaaga accaggttgc aagatttaat gacctcaggt ttgtcggtcg aagtggaaga      960

gggaaaagct tcactctgac catcactgtc ttcacaaacc caccgcaagt cgccacctac     1020

cacagagcca tcaaaatcac agtggatggg ccccgagaac ctcgaagaca tcggcagaaa     1080

ctagatgatc agaccaagcc cgggagcttg tccttttccg agcggctcag tgaactggag     1140

cagctgcggc gcacagccat gagggtcagc ccacaccacc cagcccccac gcccaaccct     1200

cgtgcctccc tgaaccactc cactgccttt aaccctcagc ctcagagtca gatgcaggat     1260

acaaggcaga tccaaccatc cccaccgtgg tcctacgatc agtcctacca atacctggga     1320

tccattgcct ctccttctgt gcacccagca acgcccattt cacctggacg tgccagcggc     1380

atgacaaccc tctctgcaga actttccagt cgactctcaa cggcacccga cctgacagcg     1440

ttcagcgacc cgcgccagtt ccccgcgctg ccctccatct ccgacccccg catgcactat     1500

ccaggcgcct tcacctactc cccgacgccg gtcacctcgg gcatcggcat cggcatgtcg     1560

gccatgggct cggccacgcg ctaccacacc tacctgccgc cgccctaccc cggctcgtcg     1620

caagcgcagg gaggcccgtt ccaagccagc tcgccctcct accacctgta ctacggcgcc     1680

tcggccggct cctaccagtt ctccatggtg ggcggcgagc gctcgccgcc gcgcatcctg     1740

ccgccctgca ccaacgcctc caccggctcc gcgctgctca accccagcct cccgaaccag     1800

agcgacgtgg tggaggccga gggcagccac agcaactccc ccaccaacat ggcgccctcc     1860

gcgcgcctgg aggaggccgt gtggaggccc tactgaggcg ccaggcctgg cccggctggg     1920

ccccgcgggc cgccgccttc gcctccgggc gcgcgggcct cctgttcgcg acaagcccgc     1980

cgggatcccg ggccctgggc ccggccaccg tcctggggcc gagggcgccc gacggccagg     2040

atctcgctgt aggtcaggcc cgcgcagcct cctgcgccca gaagcccacg ccgccgccgt     2100

ctgctggcgc cccggccctc gcggaggtgt ccgaggcgac gcacctcgag ggtgtccgcc     2160

ggccccagca cccaggggac gcgctggaaa gcaaacagga agattcccgg agggaaactg     2220

tgaatgcttc tgatttagca atgctgtgaa taaaaagaaa gattttatac ccttgactta     2280

actttttaac caagttgttt attccaaaga gtgtggaatt ttggttgggg tggggggaga     2340

ggagggatgc aactcgccct gtttggcatc taattcttat ttttaatttt tccgcacctt     2400

atcaattgca aaatgcgtat ttgcatttgg gtggttttta tttttatata cgtttatata     2460

aatatatata aattgagctt gcttctttct tgctttgacc atggaaagaa atatgattcc     2520

cttttcttta agttttattt aacttttctt ttggactttt gggtagttgt ttttttttgt     2580

tttgttttgt ttttttgaga aacagctaca gctttgggtc atttttaact actgtattcc     2640

cacaaggaat ccccagatat ttatgtatct tgatgttcag acatttatgt gttgataatt     2700

ttttaattat ttaaatgtac ttatattaag aaaaatatca agtactacat tttcttttgt     2760

tcttgatagt agccaaagtt aaatgtatca cattgaagaa ggctagaaaa aaagaatgag     2820

taatgtgatc gcttggttat ccagaagtat tgtttacatt aaactccctt tcatgttaat     2880

caaacaagtg agtagctcac gcagcaacgt ttttaatagg atttttagac actgagggtc     2940

actccaagga tcagaagtat ggaattttct gccaggctca acaagggtct catatctaac     3000

ttcctcctta aaacagagaa ggtcaatcta gttccagagg gttgaggcag gtgccaataa     3060

ttacatcttt ggagaggatt tgatttctgc ccagggattt gctcacccca aggtcatctg     3120

ataatttcac agatgctgtg taacagaaca cagccaaagt aaactgtgta ggggagccac     3180

atttacatag gaaccaaatc aatgaattta ggggttacga ttatagcaat ttaagggccc     3240

accagaagca ggcctcgagg agtcaatttg cctctgtgtg cctcagtgga gacaagtggg     3300

aaaacatggt cccacctgtg cgagaccccc tgtcctgtgc tgctcactca acaacatctt     3360

tgtgttgctt tcaccaggct gagaccctac cctatggggt atatgggctt ttacctgtgc     3420

accagtgtga caggaaagat tcatgtcact actgtccgtg gctacaattc aaaggtatcc     3480

aatgtcgctg taaattttat ggcactattt ttattggagg atttggtcag aatgcagttg     3540

ttgtacaact cataaatact aactgctgat tttgacacat gtgtgctcca aatgatctgg     3600

tggttattta acgtacctct taaaattcgt tgaaacgatt tcaggtcaac tctgaagagt     3660

atttgaaagc aggacttcag aacagtgttt gatttttatt ttataaattt aagcattcaa     3720

attaggcaaa tctttggctg caggcagcaa aaacagctgg acttatttaa aacaacttgt     3780

ttttgagttt tcttatatat atattgatta tttgttttac acacatgcag tagcactttg     3840

gtaagagtta aagagtaaag cagcttatgt tgtcaggtcg ttcttatcta gagaagagct     3900

atagcagatc tcggacaaac tcagaatata ttcactttca tttttgacag gattccctcc     3960

acaactcagt ttcatatatt attccgtatt acatttttgc agctaaatta ccataaaatg     4020

tcagcaaatg taaaaattta atttctgaaa agcaccatta gcccatttcc cccaaattaa     4080

acgtaaatgt tttttttcag cacatgttac catgtctgac ctgcaaaaat gctggagaaa     4140

aatgaaggaa aaaattatgt ttttcagttt aattctgtta actgaagata ttccaactca     4200

aaaccagcct catgctctga ttagataatc ttttacattg aacctttact ctcaaagcca     4260

tgtgtggagg gggcttgtca ctattgtagg ctcactggat tggtcattta gagtttcaca     4320

gactcttacc agcatatata gtatttaatt gtttcaaaaa aaatcaaact gtagttgttt     4380

tggcgatagg tctcacgcaa cacatttttg tatgtgtgtg tgtgtgcgtg tgtgtgtgtg     4440

tgtgtgaaaa attgcattca ttgacttcag gtagattaag gtatcttttt attcattgcc     4500

ctcaggaaag ttaaggtatc aatgagaccc ttaagccaat catgtaataa ctgcatgtgt     4560

ctggtccagg agaagtattg aataagccat ttctactgct tactcatgtc cctatttatg     4620

atttcaacat ggatacatat ttcagttctt tctttttctc actatctgaa aatacatttc     4680

cctccctctc ttccccccaa tatctccctt tttttctctc ttcctctatc ttccaaaccc     4740

cactttctcc ctcctccttt tcctgtgttc tcttaagcag atagcacata cccccaccca     4800

gtaccaaatt tcagaacaca agaaggtcca gttcttcccc cttcacataa aggaacatgg     4860

tttgtcagcc tttctcctgt ttatgggttt cttccagcag aacagagaca ttgccaacca     4920

tattggatct gcttgctgtc caaaccagca aactttcctg ggcaaatcac aatcagtgag     4980

taaatagaca gcctttctgc tgccttgggt ttctgtgcag ataaacagaa atgctctgat     5040

tagaaaggaa atgaatggtt ccactcaaat gtcctgcaat ttaggattgc agatttctgc     5100

cttgaaatac ctgtttcttt gggacattcc gtcctgatga tttttatttt tgttggtttt     5160

tatttttggg gggaatgaca tgtttgggtc ttttatacat gaaaatttgt ttgacaataa     5220

tctcacaaaa catattttac atctgaacaa aatgcctttt tgtttaccgt agcgtataca     5280

tttgttttgg gatttttgtg tgtttgttgg gaattttgtt tttagccagg tcagtattga     5340

tgaggctgat catttggctc tttttttcct tccagaagag ttgcatcaac aaagttaatt     5400

gtatttatgt atgtaaatag attttaagct tcattataaa atattgttaa tgcctataac     5460

tttttttcaa tttttttgtg tgtgtttcta aggacttttt cttaggtttg ctaaatactg     5520

tagggaaaaa aatgcttctt tctactttgt ttattttaga ctttaaaatg agctacttct     5580

tattcacttt tgtaaacagc taatagcatg gttccaattt tttttaagtt cacttttttt     5640

gttctagggg aaatgaatgt gcaaaaaaag aaaaagaact gttggttatt tgtgttattc     5700

tggatgtata aaaatcaatg gaaaaaaata aactttcaaa ttgaaatgac ggtataacac     5760

atctactgaa aaagcaacgg gaaatgtggt cctatttaag ccagccccca cctagggtct     5820

atttgtgtgg cagttattgg gtttggtcac aaaacatcct gaaaattcgt gcgtgggctt     5880

ctttctccct ggtacaaacg tatggaatgc ttcttaaagg ggaactgtca agctggtgtc     5940

ttcagccaga tgacatgaga gaatatccca gaaccctctc tccaaggtgt ttctagatag     6000

cacaggagag caggcactgc actgtccaca gtccacggta cacagtcggg tgggccgcct     6060

cccctctcct gggagcattc gtcgtgccca gcctgagcag ggcagctgga ctgctgctgt     6120

tcaggagcca ccagagcctt cctctctttg taccacagtt tcttctgtaa atccagtgtt     6180

acaatcagtg tgaatggcaa ataaacagtt tgacaagtac atacaccata                6230


<210>  16
<211>  1452
<212>  DNA
<213>  Homo sapiens

<400>  16
acagttaaat ttgtaatttg ggttgtgtga aaacttcttt gggcctcata aacaaccaca       60

gaaccacaag ttgggtagcc tggcagtgtc agaagtctga acccagcata gtggtcagca      120

ggcaggacga atcacactga atgcaaacca cagggtttcg cagcgtggta aaagaaatca      180

ttgagtcccc cgccttcaga agagggtgca ttttcaggag gaagcgatgg cttcagacag      240

catatttgag tcatttcctt cgtacccaca gtgcttcatg agagaatgca tacttggaat      300

gaatccttct agagacgtcc acgatgccag cacgagccgc cgcttcacgc cgccttccac      360

cgcgctgagc ccaggcaaga tgagcgaggc gttgccgctg ggcgccccgg acgccggcgc      420

tgccctggcc ggcaagctga ggagcggcga ccgcagcatg gtggaggtgc tggccgacca      480

cccgggcgag ctggtgcgca ccgacagccc caacttcctc tgctccgtgc tgcctacgca      540

ctggcgctgc aacaagaccc tgcccatcgc tttcaaggtg gtggccctag gggatgttcc      600

agatggcact ctggtcactg tgatggctgg caatgatgaa aactactcgg ctgagctgag      660

aaatgctacc gcagccatga agaaccaggt tgcaagattt aatgacctca ggtttgtcgg      720

tcgaagtgga agagggaaaa gcttcactct gaccatcact gtcttcacaa acccaccgca      780

agtcgccacc taccacagag ccatcaaaat cacagtggat gggccccgag aacctcgaag      840

acatcggcag aaactagatg atcagaccaa gcccgggagc ttgtcctttt ccgagcggct      900

cagtgaactg gagcagctgc ggcgcacagc catgagggtc agcccacacc acccagcccc      960

cacgcccaac cctcgtgcct ccctgaacca ctccactgcc tttaaccctc agcctcagag     1020

tcagatgcag gaggaagaca cagcaccctg gagatgttaa ggcagaagtc agttcttctg     1080

tccatccctc tccccagcca ggatagagct atcttttcca tctcatcctc agaagagact     1140

cagaagaaag atgacagccc tcagaatgca cgttatgagg aaggcagaat gtgggtctgt     1200

aattcctccg tgtcccttct ccccctctgc aaaccgtcgt aacaataata gttcctaaca     1260

catgggacaa ttgtgaggat taaatgagtt agcctgcaga aatcacttga tgcacagcac     1320

atgggaagca ttgtgtgtat ttattaatcc ttcacaaagt ctttgagata tatttttatc     1380

aaatatttag catggatccc ggtacacttt caatacttaa taaatggtca atgttattct     1440

ttttcactat ta                                                         1452


<210>  17
<211>  4693
<212>  DNA
<213>  Homo sapiens

<400>  17
acagttaaat ttgtaatttg ggttgtgtga aaacttcttt gggcctcata aacaaccaca       60

gaaccacaag ttgggtagcc tggcagtgtc agaagtctga acccagcata gtggtcagca      120

ggcaggacga atcacactga atgcaaacca cagggtttcg cagcgtggta aaagaaatca      180

ttgagtcccc cgccttcaga agagggtgca ttttcaggag gaagcgatgg cttcagacag      240

catatttgag tcatttcctt cgtacccaca gtgcttcatg agagaatgca tacttggaat      300

gaatccttct agagacgtcc acgatgccag cacgagccgc cgcttcacgc cgccttccac      360

cgcgctgagc ccaggcaaga tgagcgaggc gttgccgctg ggcgccccgg acgccggcgc      420

tgccctggcc ggcaagctga ggagcggcga ccgcagcatg gtggaggtgc tggccgacca      480

cccgggcgag ctggtgcgca ccgacagccc caacttcctc tgctccgtgc tgcctacgca      540

ctggcgctgc aacaagaccc tgcccatcgc tttcaaggtg gtggccctag gggatgttcc      600

agatggcact ctggtcactg tgatggctgg caatgatgaa aactactcgg ctgagctgag      660

aaatgctacc gcagccatga agaaccaggt tgcaagattt aatgacctca ggtttgtcgg      720

tcgaagtgga agagggaaaa gcttcactct gaccatcact gtcttcacaa acccaccgca      780

agtcgccacc taccacagag ccatcaaaat cacagtggat gggccccgag aacctcgaag      840

acatcggcag aaactagatg atcagaccaa gcccgggagc ttgtcctttt ccgagcggct      900

cagtgaactg gagcagctgc ggcgcacagc catgagggtc agcccacacc acccagcccc      960

cacgcccaac cctcgtgcct ccctgaacca ctccactgcc tttaaccctc agcctcagag     1020

tcagatgcag gatacaaggc agatccaacc atccccaccg tggtcctacg atcagtccta     1080

ccaatacctg ggatccattg cctctccttc tgtgcaccca gcaacgccca tttcacctgg     1140

acgtgccagc ggcatgacaa ccctctctgc agaactttcc agtcgactct caaacagttg     1200

tgattacttc aggtttcacc agatgcctta gctgctgttc agagcttcac agaatgcctt     1260

ctaagagctt cacaacggca gtactattga catttggggc caaataattc tttgttgggg     1320

ggggtctgtc ctgagcatcg gagaatattt agcagcatcc ttggcctcta gatgccaata     1380

gcatccccct caccccagtt aggacaataa aaaatgtttc cagacattgc caaatttccc     1440

aaggggcaaa actgtcccca ggtgagaacc actgccttcc agtgttcttg ggtggtacag     1500

taaaatagga aaaccaactt aagtgcttgg ttttcacatt acttttggcc attaatgcca     1560

atattttcat ggtacattct gctccaaggc attgagagta gcacaggtat cttggcatct     1620

tgtttagctt gtggtttcta gaagcttatc cctcaagaac aaaggcactt gtcagctttt     1680

actgattgtt ctcagggcac ccctctgcac accggctacg gtcttcacct gaaataatgc     1740

ctgttctcct tcaaatgttc ctgctatggg tctatccttt ggaatttatt acataagtct     1800

tttgacttgg tcatcaccca agatcagcac cttatagtcc aagaacccta ggggccaact     1860

cctccagctg actggtgttc agatggtagg gtgacttttt aaataaaagg aatgagtaac     1920

atgtgcactc caaagtccca tatcacagtt acatttgtga atatcctgga cttcaatcac     1980

ccaaggagta agagagaaca ttttatggca tgggagtgtg aagtagataa aaaccatgcc     2040

tcatttcaga acccaagaat gattcttttc tttttggagg gaggacagaa ttccagatga     2100

gctttcacag tggcatagaa cagtatggga gactgctctt caatttggca gaactccctc     2160

tgagaaatca agcctggagc acaggcctga aaagtgttgt cataaacctg gaggcaggag     2220

gggggtggaa tacataaaag gaaagtggct gcctggccga cagctttgag aacctgacac     2280

tgctctgtgg ctgctttgcc ttttaatcca gcccgacagc tttgtgctct gcccctcttc     2340

ccggccccag ccccacctgg gcttccttct gcgctgggga cttggactct gtctgtctct     2400

ctctctctat cctttgcaga cagactccac accttgtctg aaaagagttg tcatctagag     2460

gtttactttt ttttttcttt ttcaaaaaaa attaatgttt agctgccaac ctgggcgaca     2520

gacagcatgc attaatctga gtcatgcaaa agctcctttt aaggcagcca ttacctgctc     2580

aggttgttta atcctctggg ggcagtagga ggggccctgt agcgaggctg ctttcatcca     2640

tgtcaagctg gagagcgaag acttgagctg tcatggcaaa tatttagccc catcaatggg     2700

aaaacacttc caaccaaaat acctggacct cctaagcccc agatttccta ctcttaaaaa     2760

ctctctgtga atatcagggg atcccaactc cccccacact tctgctgaat caggggacac     2820

caggccagcc aaaaggacag aagagctaca gctggatggg tgaactgcgc agactgatgg     2880

gtttgaataa gggatctgag acaagacaca aagatgaaaa ccaacatttg aatatagcat     2940

ttgaatctga gcatatctag aaggcctaag atattgtatt atcaaaatgt gtgtaaaaaa     3000

gatagtttga ccaaatggat ggtcttttgt agtatgacgt tgctcatgtg tacatagaag     3060

aaggatcaca ggcagcattg cagctctttc ttttggatgt tctcctcaca agtgaaagaa     3120

ctattttccc ccaacagctg agaccataac atcattccag tacttatgtc catgacaaat     3180

cacggactca ctctggattc cagtaacttg gtaccatcac cacattacca tgtagtagtt     3240

ggaacctact ggcagagcat gtccagacat tgctgtaaaa cagggtgacc tttcgttcat     3300

tttccagtgg attcaccttt ttgtctcagg gcaaatgaag caagaggaat aatgggcaga     3360

gtcatttatt tgtgtccaga gtattgcatc agatgacaac aaactgactg tatttgccta     3420

atgcttttcc tcctgtccca gcttctccgt agactctata aatctaaatg gaaaaatgga     3480

gtaaagcttc ctgttaactc tcaaacatgt cacagctctc catgtcagca aaaacaagtg     3540

acacagggct tgctcacaga tggccccaaa gagcgggcag ggatgaaccc tgtggaatga     3600

ggtgtggcct ggctcgagaa tgactagagt gtggccaagg aagggcagcc tcagaaccac     3660

tgtccgttta caacgttttc cctgcccaca tgtctgcctg gctttgaaaa gattaacagg     3720

agtgtttgtt tgaaagtcag actcctggtt tcctcattag tgaagggatc tgctacagac     3780

ttgggctgtt tctataaact ttaattacct ctgatgagga gtgtatcccc tcatcacatt     3840

caccccaaag gtacagagga gttcattttt aaaaatgtgt tagagcaata aaaggccatt     3900

agagggaggg aggatggggt gtggaagaga cgagagagcg agcgagagag agagaaaaca     3960

cactagctct ccctgctgga ataataggct tgaaatatga ggaagttgat caactgccgc     4020

tgccttccaa aaacagatta atccaccttg gtagctttcc tttcagagca agcttttggc     4080

tctgtcgact ttctctatca gcctgaactc aaaaggacac aggccacatg ccatctgagc     4140

ttaagagtta ttttgtgtgt tgatctgaga acttcacatt ttaaaacaat gaattcatgt     4200

ttctactgtt tgttgctgtc tgtggatttg ctgatataaa gaggagagtc ctagcctggt     4260

catttaatga ataattctaa ggaacctgaa cttctccagg gtgcccttct acatctgcag     4320

tggtggttct cagctggggt gactttgctt ccgtcacccc acccgcagga tatctggcaa     4380

tgtctggaga cattctgagt tgtcacaaga ggggcgggcg atgctactaa cacctaatgg     4440

gtaaagcaga gatgctgcca cacatcctac gatgaacgag acagccccct ccaccccagc     4500

aaatcatgat ctggcccaaa atgtcaacag tgtcaacagt tgagaaactc tgatctacag     4560

atatagggaa ccctgcctaa tacacaaatc ctccgtagtt cccaagggcg gcctgtagcg     4620

gcacccgacc tgacagcgtt cagcgacccg cgccagttcc ccgcgctgcc ctccatctcc     4680

gacccccgca tgc                                                        4693


<210>  18
<211>  5772
<212>  DNA
<213>  Homo sapiens

<400>  18
acagttaaat ttgtaatttg ggttgtgtga aaacttcttt gggcctcata aacaaccaca       60

gaaccacaag ttgggtagcc tggcagtgtc agaagtctga acccagcata gtggtcagca      120

ggcaggacga atcacactga atgcaaacca cagggtttcg cagcgtggta aaagaaatca      180

ttgagtcccc cgccttcaga agagggtgca ttttcaggag gaagcgatgg cttcagacag      240

catatttgag tcatttcctt cgtacccaca gtgcttcatg agagatgcca gcacgagccg      300

ccgcttcacg ccgccttcca ccgcgctgag cccaggcaag atgagcgagg cgttgccgct      360

gggcgccccg gacgccggcg ctgccctggc cggcaagctg aggagcggcg accgcagcat      420

ggtggaggtg ctggccgacc acccgggcga gctggtgcgc accgacagcc ccaacttcct      480

ctgctccgtg ctgcctacgc actggcgctg caacaagacc ctgcccatcg ctttcaaggt      540

ggtggcccta ggggatgttc cagatggcac tctggtcact gtgatggctg gcaatgatga      600

aaactactcg gctgagctga gaaatgctac cgcagccatg aagaaccagg ttgcaagatt      660

taatgacctc aggtttgtcg gtcgaagtgg aagagggaaa agcttcactc tgaccatcac      720

tgtcttcaca aacccaccgc aagtcgccac ctaccacaga gccatcaaaa tcacagtgga      780

tgggccccga gaacctcgaa atacaaggca gatccaacca tccccaccgt ggtcctacga      840

tcagtcctac caatacctgg gatccattgc ctctccttct gtgcacccag caacgcccat      900

ttcacctgga cgtgccagcg gcatgacaac cctctctgca gaactttcca gtcgactctc      960

aacggcaccc gacctgacag cgttcagcga cccgcgccag ttccccgcgc tgccctccat     1020

ctccgacccc cgcatgcact atccaggcgc cttcacctac tccccgacgc cggtcacctc     1080

gggcatcggc atcggcatgt cggccatggg ctcggccacg cgctaccaca cctacctgcc     1140

gccgccctac cccggctcgt cgcaagcgca gggaggcccg ttccaagcca gctcgccctc     1200

ctaccacctg tactacggcg cctcggccgg ctcctaccag ttctccatgg tgggcggcga     1260

gcgctcgccg ccgcgcatcc tgccgccctg caccaacgcc tccaccggct ccgcgctgct     1320

caaccccagc ctcccgaacc agagcgacgt ggtggaggcc gagggcagcc acagcaactc     1380

ccccaccaac atggcgccct ccgcgcgcct ggaggaggcc gtgtggaggc cctactgagg     1440

cgccaggcct ggcccggctg ggccccgcgg gccgccgcct tcgcctccgg gcgcgcgggc     1500

ctcctgttcg cgacaagccc gccgggatcc cgggccctgg gcccggccac cgtcctgggg     1560

ccgagggcgc ccgacggcca ggatctcgct gtaggtcagg cccgcgcagc ctcctgcgcc     1620

cagaagccca cgccgccgcc gtctgctggc gccccggccc tcgcggaggt gtccgaggcg     1680

acgcacctcg agggtgtccg ccggccccag cacccagggg acgcgctgga aagcaaacag     1740

gaagattccc ggagggaaac tgtgaatgct tctgatttag caatgctgtg aataaaaaga     1800

aagattttat acccttgact taacttttta accaagttgt ttattccaaa gagtgtggaa     1860

ttttggttgg ggtgggggga gaggagggat gcaactcgcc ctgtttggca tctaattctt     1920

atttttaatt tttccgcacc ttatcaattg caaaatgcgt atttgcattt gggtggtttt     1980

tatttttata tacgtttata taaatatata taaattgagc ttgcttcttt cttgctttga     2040

ccatggaaag aaatatgatt cccttttctt taagttttat ttaacttttc ttttggactt     2100

ttgggtagtt gttttttttt gttttgtttt gtttttttga gaaacagcta cagctttggg     2160

tcatttttaa ctactgtatt cccacaagga atccccagat atttatgtat cttgatgttc     2220

agacatttat gtgttgataa ttttttaatt atttaaatgt acttatatta agaaaaatat     2280

caagtactac attttctttt gttcttgata gtagccaaag ttaaatgtat cacattgaag     2340

aaggctagaa aaaaagaatg agtaatgtga tcgcttggtt atccagaagt attgtttaca     2400

ttaaactccc tttcatgtta atcaaacaag tgagtagctc acgcagcaac gtttttaata     2460

ggatttttag acactgaggg tcactccaag gatcagaagt atggaatttt ctgccaggct     2520

caacaagggt ctcatatcta acttcctcct taaaacagag aaggtcaatc tagttccaga     2580

gggttgaggc aggtgccaat aattacatct ttggagagga tttgatttct gcccagggat     2640

ttgctcaccc caaggtcatc tgataatttc acagatgctg tgtaacagaa cacagccaaa     2700

gtaaactgtg taggggagcc acatttacat aggaaccaaa tcaatgaatt taggggttac     2760

gattatagca atttaagggc ccaccagaag caggcctcga ggagtcaatt tgcctctgtg     2820

tgcctcagtg gagacaagtg ggaaaacatg gtcccacctg tgcgagaccc cctgtcctgt     2880

gctgctcact caacaacatc tttgtgttgc tttcaccagg ctgagaccct accctatggg     2940

gtatatgggc ttttacctgt gcaccagtgt gacaggaaag attcatgtca ctactgtccg     3000

tggctacaat tcaaaggtat ccaatgtcgc tgtaaatttt atggcactat ttttattgga     3060

ggatttggtc agaatgcagt tgttgtacaa ctcataaata ctaactgctg attttgacac     3120

atgtgtgctc caaatgatct ggtggttatt taacgtacct cttaaaattc gttgaaacga     3180

tttcaggtca actctgaaga gtatttgaaa gcaggacttc agaacagtgt ttgattttta     3240

ttttataaat ttaagcattc aaattaggca aatctttggc tgcaggcagc aaaaacagct     3300

ggacttattt aaaacaactt gtttttgagt tttcttatat atatattgat tatttgtttt     3360

acacacatgc agtagcactt tggtaagagt taaagagtaa agcagcttat gttgtcaggt     3420

cgttcttatc tagagaagag ctatagcaga tctcggacaa actcagaata tattcacttt     3480

catttttgac aggattccct ccacaactca gtttcatata ttattccgta ttacattttt     3540

gcagctaaat taccataaaa tgtcagcaaa tgtaaaaatt taatttctga aaagcaccat     3600

tagcccattt cccccaaatt aaacgtaaat gttttttttc agcacatgtt accatgtctg     3660

acctgcaaaa atgctggaga aaaatgaagg aaaaaattat gtttttcagt ttaattctgt     3720

taactgaaga tattccaact caaaaccagc ctcatgctct gattagataa tcttttacat     3780

tgaaccttta ctctcaaagc catgtgtgga gggggcttgt cactattgta ggctcactgg     3840

attggtcatt tagagtttca cagactctta ccagcatata tagtatttaa ttgtttcaaa     3900

aaaaatcaaa ctgtagttgt tttggcgata ggtctcacgc aacacatttt tgtatgtgtg     3960

tgtgtgtgcg tgtgtgtgtg tgtgtgtgaa aaattgcatt cattgacttc aggtagatta     4020

aggtatcttt ttattcattg ccctcaggaa agttaaggta tcaatgagac ccttaagcca     4080

atcatgtaat aactgcatgt gtctggtcca ggagaagtat tgaataagcc atttctactg     4140

cttactcatg tccctattta tgatttcaac atggatacat atttcagttc tttctttttc     4200

tcactatctg aaaatacatt tccctccctc tcttcccccc aatatctccc tttttttctc     4260

tcttcctcta tcttccaaac cccactttct ccctcctcct tttcctgtgt tctcttaagc     4320

agatagcaca tacccccacc cagtaccaaa tttcagaaca caagaaggtc cagttcttcc     4380

cccttcacat aaaggaacat ggtttgtcag cctttctcct gtttatgggt ttcttccagc     4440

agaacagaga cattgccaac catattggat ctgcttgctg tccaaaccag caaactttcc     4500

tgggcaaatc acaatcagtg agtaaataga cagcctttct gctgccttgg gtttctgtgc     4560

agataaacag aaatgctctg attagaaagg aaatgaatgg ttccactcaa atgtcctgca     4620

atttaggatt gcagatttct gccttgaaat acctgtttct ttgggacatt ccgtcctgat     4680

gatttttatt tttgttggtt tttatttttg gggggaatga catgtttggg tcttttatac     4740

atgaaaattt gtttgacaat aatctcacaa aacatatttt acatctgaac aaaatgcctt     4800

tttgtttacc gtagcgtata catttgtttt gggatttttg tgtgtttgtt gggaattttg     4860

tttttagcca ggtcagtatt gatgaggctg atcatttggc tctttttttc cttccagaag     4920

agttgcatca acaaagttaa ttgtatttat gtatgtaaat agattttaag cttcattata     4980

aaatattgtt aatgcctata actttttttc aatttttttg tgtgtgtttc taaggacttt     5040

ttcttaggtt tgctaaatac tgtagggaaa aaaatgcttc tttctacttt gtttatttta     5100

gactttaaaa tgagctactt cttattcact tttgtaaaca gctaatagca tggttccaat     5160

tttttttaag ttcacttttt ttgttctagg ggaaatgaat gtgcaaaaaa agaaaaagaa     5220

ctgttggtta tttgtgttat tctggatgta taaaaatcaa tggaaaaaaa taaactttca     5280

aattgaaatg acggtataac acatctactg aaaaagcaac gggaaatgtg gtcctattta     5340

agccagcccc cacctagggt ctatttgtgt ggcagttatt gggtttggtc acaaaacatc     5400

ctgaaaattc gtgcgtgggc ttctttctcc ctggtacaaa cgtatggaat gcttcttaaa     5460

ggggaactgt caagctggtg tcttcagcca gatgacatga gagaatatcc cagaaccctc     5520

tctccaaggt gtttctagat agcacaggag agcaggcact gcactgtcca cagtccacgg     5580

tacacagtcg ggtgggccgc ctcccctctc ctgggagcat tcgtcgtgcc cagcctgagc     5640

agggcagctg gactgctgct gttcaggagc caccagagcc ttcctctctt tgtaccacag     5700

tttcttctgt aaatccagtg ttacaatcag tgtgaatggc aaataaacag tttgacaagt     5760

acatacacca ta                                                         5772


<210>  19
<211>  5811
<212>  DNA
<213>  Homo sapiens

<400>  19
acagttaaat ttgtaatttg ggttgtgtga aaacttcttt gggcctcata aacaaccaca       60

gaaccacaag ttgggtagcc tggcagtgtc agaagtctga acccagcata gtggtcagca      120

ggcaggacga atcacactga atgcaaacca cagggtttcg cagcgtggta aaagaaatca      180

ttgagtcccc cgccttcaga agagggtgca ttttcaggag gaagcgatgg cttcagacag      240

catatttgag tcatttcctt cgtacccaca gtgcttcatg agagaatgca tacttggaat      300

gaatccttct agagacgtcc acgatgccag cacgagccgc cgcttcacgc cgccttccac      360

cgcgctgagc ccaggcaaga tgagcgaggc gttgccgctg ggcgccccgg acgccggcgc      420

tgccctggcc ggcaagctga ggagcggcga ccgcagcatg gtggaggtgc tggccgacca      480

cccgggcgag ctggtgcgca ccgacagccc caacttcctc tgctccgtgc tgcctacgca      540

ctggcgctgc aacaagaccc tgcccatcgc tttcaaggtg gtggccctag gggatgttcc      600

agatggcact ctggtcactg tgatggctgg caatgatgaa aactactcgg ctgagctgag      660

aaatgctacc gcagccatga agaaccaggt tgcaagattt aatgacctca ggtttgtcgg      720

tcgaagtgga agagggaaaa gcttcactct gaccatcact gtcttcacaa acccaccgca      780

agtcgccacc taccacagag ccatcaaaat cacagtggat gggccccgag aacctcgaaa      840

tacaaggcag atccaaccat ccccaccgtg gtcctacgat cagtcctacc aatacctggg      900

atccattgcc tctccttctg tgcacccagc aacgcccatt tcacctggac gtgccagcgg      960

catgacaacc ctctctgcag aactttccag tcgactctca acggcacccg acctgacagc     1020

gttcagcgac ccgcgccagt tccccgcgct gccctccatc tccgaccccc gcatgcacta     1080

tccaggcgcc ttcacctact ccccgacgcc ggtcacctcg ggcatcggca tcggcatgtc     1140

ggccatgggc tcggccacgc gctaccacac ctacctgccg ccgccctacc ccggctcgtc     1200

gcaagcgcag ggaggcccgt tccaagccag ctcgccctcc taccacctgt actacggcgc     1260

ctcggccggc tcctaccagt tctccatggt gggcggcgag cgctcgccgc cgcgcatcct     1320

gccgccctgc accaacgcct ccaccggctc cgcgctgctc aaccccagcc tcccgaacca     1380

gagcgacgtg gtggaggccg agggcagcca cagcaactcc cccaccaaca tggcgccctc     1440

cgcgcgcctg gaggaggccg tgtggaggcc ctactgaggc gccaggcctg gcccggctgg     1500

gccccgcggg ccgccgcctt cgcctccggg cgcgcgggcc tcctgttcgc gacaagcccg     1560

ccgggatccc gggccctggg cccggccacc gtcctggggc cgagggcgcc cgacggccag     1620

gatctcgctg taggtcaggc ccgcgcagcc tcctgcgccc agaagcccac gccgccgccg     1680

tctgctggcg ccccggccct cgcggaggtg tccgaggcga cgcacctcga gggtgtccgc     1740

cggccccagc acccagggga cgcgctggaa agcaaacagg aagattcccg gagggaaact     1800

gtgaatgctt ctgatttagc aatgctgtga ataaaaagaa agattttata cccttgactt     1860

aactttttaa ccaagttgtt tattccaaag agtgtggaat tttggttggg gtggggggag     1920

aggagggatg caactcgccc tgtttggcat ctaattctta tttttaattt ttccgcacct     1980

tatcaattgc aaaatgcgta tttgcatttg ggtggttttt atttttatat acgtttatat     2040

aaatatatat aaattgagct tgcttctttc ttgctttgac catggaaaga aatatgattc     2100

ccttttcttt aagttttatt taacttttct tttggacttt tgggtagttg tttttttttg     2160

ttttgttttg tttttttgag aaacagctac agctttgggt catttttaac tactgtattc     2220

ccacaaggaa tccccagata tttatgtatc ttgatgttca gacatttatg tgttgataat     2280

tttttaatta tttaaatgta cttatattaa gaaaaatatc aagtactaca ttttcttttg     2340

ttcttgatag tagccaaagt taaatgtatc acattgaaga aggctagaaa aaaagaatga     2400

gtaatgtgat cgcttggtta tccagaagta ttgtttacat taaactccct ttcatgttaa     2460

tcaaacaagt gagtagctca cgcagcaacg tttttaatag gatttttaga cactgagggt     2520

cactccaagg atcagaagta tggaattttc tgccaggctc aacaagggtc tcatatctaa     2580

cttcctcctt aaaacagaga aggtcaatct agttccagag ggttgaggca ggtgccaata     2640

attacatctt tggagaggat ttgatttctg cccagggatt tgctcacccc aaggtcatct     2700

gataatttca cagatgctgt gtaacagaac acagccaaag taaactgtgt aggggagcca     2760

catttacata ggaaccaaat caatgaattt aggggttacg attatagcaa tttaagggcc     2820

caccagaagc aggcctcgag gagtcaattt gcctctgtgt gcctcagtgg agacaagtgg     2880

gaaaacatgg tcccacctgt gcgagacccc ctgtcctgtg ctgctcactc aacaacatct     2940

ttgtgttgct ttcaccaggc tgagacccta ccctatgggg tatatgggct tttacctgtg     3000

caccagtgtg acaggaaaga ttcatgtcac tactgtccgt ggctacaatt caaaggtatc     3060

caatgtcgct gtaaatttta tggcactatt tttattggag gatttggtca gaatgcagtt     3120

gttgtacaac tcataaatac taactgctga ttttgacaca tgtgtgctcc aaatgatctg     3180

gtggttattt aacgtacctc ttaaaattcg ttgaaacgat ttcaggtcaa ctctgaagag     3240

tatttgaaag caggacttca gaacagtgtt tgatttttat tttataaatt taagcattca     3300

aattaggcaa atctttggct gcaggcagca aaaacagctg gacttattta aaacaacttg     3360

tttttgagtt ttcttatata tatattgatt atttgtttta cacacatgca gtagcacttt     3420

ggtaagagtt aaagagtaaa gcagcttatg ttgtcaggtc gttcttatct agagaagagc     3480

tatagcagat ctcggacaaa ctcagaatat attcactttc atttttgaca ggattccctc     3540

cacaactcag tttcatatat tattccgtat tacatttttg cagctaaatt accataaaat     3600

gtcagcaaat gtaaaaattt aatttctgaa aagcaccatt agcccatttc ccccaaatta     3660

aacgtaaatg ttttttttca gcacatgtta ccatgtctga cctgcaaaaa tgctggagaa     3720

aaatgaagga aaaaattatg tttttcagtt taattctgtt aactgaagat attccaactc     3780

aaaaccagcc tcatgctctg attagataat cttttacatt gaacctttac tctcaaagcc     3840

atgtgtggag ggggcttgtc actattgtag gctcactgga ttggtcattt agagtttcac     3900

agactcttac cagcatatat agtatttaat tgtttcaaaa aaaatcaaac tgtagttgtt     3960

ttggcgatag gtctcacgca acacattttt gtatgtgtgt gtgtgtgcgt gtgtgtgtgt     4020

gtgtgtgaaa aattgcattc attgacttca ggtagattaa ggtatctttt tattcattgc     4080

cctcaggaaa gttaaggtat caatgagacc cttaagccaa tcatgtaata actgcatgtg     4140

tctggtccag gagaagtatt gaataagcca tttctactgc ttactcatgt ccctatttat     4200

gatttcaaca tggatacata tttcagttct ttctttttct cactatctga aaatacattt     4260

ccctccctct cttcccccca atatctccct ttttttctct cttcctctat cttccaaacc     4320

ccactttctc cctcctcctt ttcctgtgtt ctcttaagca gatagcacat acccccaccc     4380

agtaccaaat ttcagaacac aagaaggtcc agttcttccc ccttcacata aaggaacatg     4440

gtttgtcagc ctttctcctg tttatgggtt tcttccagca gaacagagac attgccaacc     4500

atattggatc tgcttgctgt ccaaaccagc aaactttcct gggcaaatca caatcagtga     4560

gtaaatagac agcctttctg ctgccttggg tttctgtgca gataaacaga aatgctctga     4620

ttagaaagga aatgaatggt tccactcaaa tgtcctgcaa tttaggattg cagatttctg     4680

ccttgaaata cctgtttctt tgggacattc cgtcctgatg atttttattt ttgttggttt     4740

ttatttttgg ggggaatgac atgtttgggt cttttataca tgaaaatttg tttgacaata     4800

atctcacaaa acatatttta catctgaaca aaatgccttt ttgtttaccg tagcgtatac     4860

atttgttttg ggatttttgt gtgtttgttg ggaattttgt ttttagccag gtcagtattg     4920

atgaggctga tcatttggct ctttttttcc ttccagaaga gttgcatcaa caaagttaat     4980

tgtatttatg tatgtaaata gattttaagc ttcattataa aatattgtta atgcctataa     5040

ctttttttca atttttttgt gtgtgtttct aaggactttt tcttaggttt gctaaatact     5100

gtagggaaaa aaatgcttct ttctactttg tttattttag actttaaaat gagctacttc     5160

ttattcactt ttgtaaacag ctaatagcat ggttccaatt ttttttaagt tcactttttt     5220

tgttctaggg gaaatgaatg tgcaaaaaaa gaaaaagaac tgttggttat ttgtgttatt     5280

ctggatgtat aaaaatcaat ggaaaaaaat aaactttcaa attgaaatga cggtataaca     5340

catctactga aaaagcaacg ggaaatgtgg tcctatttaa gccagccccc acctagggtc     5400

tatttgtgtg gcagttattg ggtttggtca caaaacatcc tgaaaattcg tgcgtgggct     5460

tctttctccc tggtacaaac gtatggaatg cttcttaaag gggaactgtc aagctggtgt     5520

cttcagccag atgacatgag agaatatccc agaaccctct ctccaaggtg tttctagata     5580

gcacaggaga gcaggcactg cactgtccac agtccacggt acacagtcgg gtgggccgcc     5640

tcccctctcc tgggagcatt cgtcgtgccc agcctgagca gggcagctgg actgctgctg     5700

ttcaggagcc accagagcct tcctctcttt gtaccacagt ttcttctgta aatccagtgt     5760

tacaatcagt gtgaatggca aataaacagt ttgacaagta catacaccat a              5811


<210>  20
<211>  5772
<212>  DNA
<213>  Homo sapiens

<400>  20
cactttttaa tgcactaagc aatcggttgc taggagccca tcctgggtca gaggccgatc       60

cgcagaacca gaacgttttc ccctcctgga ctatgccagc acgagccgcc gcttcacgcc      120

gccttccacc gcgctgagcc caggcaagat gagcgaggcg ttgccgctgg gcgccccgga      180

cgccggcgct gccctggccg gcaagctgag gagcggcgac cgcagcatgg tggaggtgct      240

ggccgaccac ccgggcgagc tggtgcgcac cgacagcccc aacttcctct gctccgtgct      300

gcctacgcac tggcgctgca acaagaccct gcccatcgct ttcaaggtgg tggccctagg      360

ggatgttcca gatggcactc tggtcactgt gatggctggc aatgatgaaa actactcggc      420

tgagctgaga aatgctaccg cagccatgaa gaaccaggtt gcaagattta atgacctcag      480

gtttgtcggt cgaagtggaa gagggaaaag cttcactctg accatcactg tcttcacaaa      540

cccaccgcaa gtcgccacct accacagagc catcaaaatc acagtggatg ggccccgaga      600

acctcgaaga catcggcaga aactagatga tcagaccaag cccgggagct tgtccttttc      660

cgagcggctc agtgaactgg agcagctgcg gcgcacagcc atgagggtca gcccacacca      720

cccagccccc acgcccaacc ctcgtgcctc cctgaaccac tccactgcct ttaaccctca      780

gcctcagagt cagatgcagg atacaaggca gatccaacca tccccaccgt ggtcctacga      840

tcagtcctac caatacctgg gatccattgc ctctccttct gtgcacccag caacgcccat      900

ttcacctgga cgtgccagcg gcatgacaac cctctctgca gaactttcca gtcgactctc      960

aacggcaccc gacctgacag cgttcagcga cccgcgccag ttccccgcgc tgccctccat     1020

ctccgacccc cgcatgcact atccaggcgc cttcacctac tccccgacgc cggtcacctc     1080

gggcatcggc atcggcatgt cggccatggg ctcggccacg cgctaccaca cctacctgcc     1140

gccgccctac cccggctcgt cgcaagcgca gggaggcccg ttccaagcca gctcgccctc     1200

ctaccacctg tactacggcg cctcggccgg ctcctaccag ttctccatgg tgggcggcga     1260

gcgctcgccg ccgcgcatcc tgccgccctg caccaacgcc tccaccggct ccgcgctgct     1320

caaccccagc ctcccgaacc agagcgacgt ggtggaggcc gagggcagcc acagcaactc     1380

ccccaccaac atggcgccct ccgcgcgcct ggaggaggcc gtgtggaggc cctactgagg     1440

cgccaggcct ggcccggctg ggccccgcgg gccgccgcct tcgcctccgg gcgcgcgggc     1500

ctcctgttcg cgacaagccc gccgggatcc cgggccctgg gcccggccac cgtcctgggg     1560

ccgagggcgc ccgacggcca ggatctcgct gtaggtcagg cccgcgcagc ctcctgcgcc     1620

cagaagccca cgccgccgcc gtctgctggc gccccggccc tcgcggaggt gtccgaggcg     1680

acgcacctcg agggtgtccg ccggccccag cacccagggg acgcgctgga aagcaaacag     1740

gaagattccc ggagggaaac tgtgaatgct tctgatttag caatgctgtg aataaaaaga     1800

aagattttat acccttgact taacttttta accaagttgt ttattccaaa gagtgtggaa     1860

ttttggttgg ggtgggggga gaggagggat gcaactcgcc ctgtttggca tctaattctt     1920

atttttaatt tttccgcacc ttatcaattg caaaatgcgt atttgcattt gggtggtttt     1980

tatttttata tacgtttata taaatatata taaattgagc ttgcttcttt cttgctttga     2040

ccatggaaag aaatatgatt cccttttctt taagttttat ttaacttttc ttttggactt     2100

ttgggtagtt gttttttttt gttttgtttt gtttttttga gaaacagcta cagctttggg     2160

tcatttttaa ctactgtatt cccacaagga atccccagat atttatgtat cttgatgttc     2220

agacatttat gtgttgataa ttttttaatt atttaaatgt acttatatta agaaaaatat     2280

caagtactac attttctttt gttcttgata gtagccaaag ttaaatgtat cacattgaag     2340

aaggctagaa aaaaagaatg agtaatgtga tcgcttggtt atccagaagt attgtttaca     2400

ttaaactccc tttcatgtta atcaaacaag tgagtagctc acgcagcaac gtttttaata     2460

ggatttttag acactgaggg tcactccaag gatcagaagt atggaatttt ctgccaggct     2520

caacaagggt ctcatatcta acttcctcct taaaacagag aaggtcaatc tagttccaga     2580

gggttgaggc aggtgccaat aattacatct ttggagagga tttgatttct gcccagggat     2640

ttgctcaccc caaggtcatc tgataatttc acagatgctg tgtaacagaa cacagccaaa     2700

gtaaactgtg taggggagcc acatttacat aggaaccaaa tcaatgaatt taggggttac     2760

gattatagca atttaagggc ccaccagaag caggcctcga ggagtcaatt tgcctctgtg     2820

tgcctcagtg gagacaagtg ggaaaacatg gtcccacctg tgcgagaccc cctgtcctgt     2880

gctgctcact caacaacatc tttgtgttgc tttcaccagg ctgagaccct accctatggg     2940

gtatatgggc ttttacctgt gcaccagtgt gacaggaaag attcatgtca ctactgtccg     3000

tggctacaat tcaaaggtat ccaatgtcgc tgtaaatttt atggcactat ttttattgga     3060

ggatttggtc agaatgcagt tgttgtacaa ctcataaata ctaactgctg attttgacac     3120

atgtgtgctc caaatgatct ggtggttatt taacgtacct cttaaaattc gttgaaacga     3180

tttcaggtca actctgaaga gtatttgaaa gcaggacttc agaacagtgt ttgattttta     3240

ttttataaat ttaagcattc aaattaggca aatctttggc tgcaggcagc aaaaacagct     3300

ggacttattt aaaacaactt gtttttgagt tttcttatat atatattgat tatttgtttt     3360

acacacatgc agtagcactt tggtaagagt taaagagtaa agcagcttat gttgtcaggt     3420

cgttcttatc tagagaagag ctatagcaga tctcggacaa actcagaata tattcacttt     3480

catttttgac aggattccct ccacaactca gtttcatata ttattccgta ttacattttt     3540

gcagctaaat taccataaaa tgtcagcaaa tgtaaaaatt taatttctga aaagcaccat     3600

tagcccattt cccccaaatt aaacgtaaat gttttttttc agcacatgtt accatgtctg     3660

acctgcaaaa atgctggaga aaaatgaagg aaaaaattat gtttttcagt ttaattctgt     3720

taactgaaga tattccaact caaaaccagc ctcatgctct gattagataa tcttttacat     3780

tgaaccttta ctctcaaagc catgtgtgga gggggcttgt cactattgta ggctcactgg     3840

attggtcatt tagagtttca cagactctta ccagcatata tagtatttaa ttgtttcaaa     3900

aaaaatcaaa ctgtagttgt tttggcgata ggtctcacgc aacacatttt tgtatgtgtg     3960

tgtgtgtgcg tgtgtgtgtg tgtgtgtgaa aaattgcatt cattgacttc aggtagatta     4020

aggtatcttt ttattcattg ccctcaggaa agttaaggta tcaatgagac ccttaagcca     4080

atcatgtaat aactgcatgt gtctggtcca ggagaagtat tgaataagcc atttctactg     4140

cttactcatg tccctattta tgatttcaac atggatacat atttcagttc tttctttttc     4200

tcactatctg aaaatacatt tccctccctc tcttcccccc aatatctccc tttttttctc     4260

tcttcctcta tcttccaaac cccactttct ccctcctcct tttcctgtgt tctcttaagc     4320

agatagcaca tacccccacc cagtaccaaa tttcagaaca caagaaggtc cagttcttcc     4380

cccttcacat aaaggaacat ggtttgtcag cctttctcct gtttatgggt ttcttccagc     4440

agaacagaga cattgccaac catattggat ctgcttgctg tccaaaccag caaactttcc     4500

tgggcaaatc acaatcagtg agtaaataga cagcctttct gctgccttgg gtttctgtgc     4560

agataaacag aaatgctctg attagaaagg aaatgaatgg ttccactcaa atgtcctgca     4620

atttaggatt gcagatttct gccttgaaat acctgtttct ttgggacatt ccgtcctgat     4680

gatttttatt tttgttggtt tttatttttg gggggaatga catgtttggg tcttttatac     4740

atgaaaattt gtttgacaat aatctcacaa aacatatttt acatctgaac aaaatgcctt     4800

tttgtttacc gtagcgtata catttgtttt gggatttttg tgtgtttgtt gggaattttg     4860

tttttagcca ggtcagtatt gatgaggctg atcatttggc tctttttttc cttccagaag     4920

agttgcatca acaaagttaa ttgtatttat gtatgtaaat agattttaag cttcattata     4980

aaatattgtt aatgcctata actttttttc aatttttttg tgtgtgtttc taaggacttt     5040

ttcttaggtt tgctaaatac tgtagggaaa aaaatgcttc tttctacttt gtttatttta     5100

gactttaaaa tgagctactt cttattcact tttgtaaaca gctaatagca tggttccaat     5160

tttttttaag ttcacttttt ttgttctagg ggaaatgaat gtgcaaaaaa agaaaaagaa     5220

ctgttggtta tttgtgttat tctggatgta taaaaatcaa tggaaaaaaa taaactttca     5280

aattgaaatg acggtataac acatctactg aaaaagcaac gggaaatgtg gtcctattta     5340

agccagcccc cacctagggt ctatttgtgt ggcagttatt gggtttggtc acaaaacatc     5400

ctgaaaattc gtgcgtgggc ttctttctcc ctggtacaaa cgtatggaat gcttcttaaa     5460

ggggaactgt caagctggtg tcttcagcca gatgacatga gagaatatcc cagaaccctc     5520

tctccaaggt gtttctagat agcacaggag agcaggcact gcactgtcca cagtccacgg     5580

tacacagtcg ggtgggccgc ctcccctctc ctgggagcat tcgtcgtgcc cagcctgagc     5640

agggcagctg gactgctgct gttcaggagc caccagagcc ttcctctctt tgtaccacag     5700

tttcttctgt aaatccagtg ttacaatcag tgtgaatggc aaataaacag tttgacaagt     5760

acatacacca ta                                                         5772


<210>  21
<211>  5964
<212>  DNA
<213>  Homo sapiens

<400>  21
acagttaaat ttgtaatttg ggttgtgtga aaacttcttt gggcctcata aacaaccaca       60

gaaccacaag ttgggtagcc tggcagtgtc agaagtctga acccagcata gtggtcagca      120

ggcaggacga atcacactga atgcaaacca cagggtttcg cagcgtggta aaagaaatca      180

ttgagtcccc cgccttcaga agagggtgca ttttcaggag gaagcgatgg cttcagacag      240

catatttgag tcatttcctt cgtacccaca gtgcttcatg agagatgcca gcacgagccg      300

ccgcttcacg ccgccttcca ccgcgctgag cccaggcaag atgagcgagg cgttgccgct      360

gggcgccccg gacgccggcg ctgccctggc cggcaagctg aggagcggcg accgcagcat      420

ggtggaggtg ctggccgacc acccgggcga gctggtgcgc accgacagcc ccaacttcct      480

ctgctccgtg ctgcctacgc actggcgctg caacaagacc ctgcccatcg ctttcaaggt      540

ggtggcccta ggggatgttc cagatggcac tctggtcact gtgatggctg gcaatgatga      600

aaactactcg gctgagctga gaaatgctac cgcagccatg aagaaccagg ttgcaagatt      660

taatgacctc aggtttgtcg gtcgaagtgg aagagggaaa agcttcactc tgaccatcac      720

tgtcttcaca aacccaccgc aagtcgccac ctaccacaga gccatcaaaa tcacagtgga      780

tgggccccga gaacctcgaa gacatcggca gaaactagat gatcagacca agcccgggag      840

cttgtccttt tccgagcggc tcagtgaact ggagcagctg cggcgcacag ccatgagggt      900

cagcccacac cacccagccc ccacgcccaa ccctcgtgcc tccctgaacc actccactgc      960

ctttaaccct cagcctcaga gtcagatgca ggatacaagg cagatccaac catccccacc     1020

gtggtcctac gatcagtcct accaatacct gggatccatt gcctctcctt ctgtgcaccc     1080

agcaacgccc atttcacctg gacgtgccag cggcatgaca accctctctg cagaactttc     1140

cagtcgactc tcaacggcac ccgacctgac agcgttcagc gacccgcgcc agttccccgc     1200

gctgccctcc atctccgacc cccgcatgca ctatccaggc gccttcacct actccccgac     1260

gccggtcacc tcgggcatcg gcatcggcat gtcggccatg ggctcggcca cgcgctacca     1320

cacctacctg ccgccgccct accccggctc gtcgcaagcg cagggaggcc cgttccaagc     1380

cagctcgccc tcctaccacc tgtactacgg cgcctcggcc ggctcctacc agttctccat     1440

ggtgggcggc gagcgctcgc cgccgcgcat cctgccgccc tgcaccaacg cctccaccgg     1500

ctccgcgctg ctcaacccca gcctcccgaa ccagagcgac gtggtggagg ccgagggcag     1560

ccacagcaac tcccccacca acatggcgcc ctccgcgcgc ctggaggagg ccgtgtggag     1620

gccctactga ggcgccaggc ctggcccggc tgggccccgc gggccgccgc cttcgcctcc     1680

gggcgcgcgg gcctcctgtt cgcgacaagc ccgccgggat cccgggccct gggcccggcc     1740

accgtcctgg ggccgagggc gcccgacggc caggatctcg ctgtaggtca ggcccgcgca     1800

gcctcctgcg cccagaagcc cacgccgccg ccgtctgctg gcgccccggc cctcgcggag     1860

gtgtccgagg cgacgcacct cgagggtgtc cgccggcccc agcacccagg ggacgcgctg     1920

gaaagcaaac aggaagattc ccggagggaa actgtgaatg cttctgattt agcaatgctg     1980

tgaataaaaa gaaagatttt atacccttga cttaactttt taaccaagtt gtttattcca     2040

aagagtgtgg aattttggtt ggggtggggg gagaggaggg atgcaactcg ccctgtttgg     2100

catctaattc ttatttttaa tttttccgca ccttatcaat tgcaaaatgc gtatttgcat     2160

ttgggtggtt tttattttta tatacgttta tataaatata tataaattga gcttgcttct     2220

ttcttgcttt gaccatggaa agaaatatga ttcccttttc tttaagtttt atttaacttt     2280

tcttttggac ttttgggtag ttgttttttt ttgttttgtt ttgttttttt gagaaacagc     2340

tacagctttg ggtcattttt aactactgta ttcccacaag gaatccccag atatttatgt     2400

atcttgatgt tcagacattt atgtgttgat aattttttaa ttatttaaat gtacttatat     2460

taagaaaaat atcaagtact acattttctt ttgttcttga tagtagccaa agttaaatgt     2520

atcacattga agaaggctag aaaaaaagaa tgagtaatgt gatcgcttgg ttatccagaa     2580

gtattgttta cattaaactc cctttcatgt taatcaaaca agtgagtagc tcacgcagca     2640

acgtttttaa taggattttt agacactgag ggtcactcca aggatcagaa gtatggaatt     2700

ttctgccagg ctcaacaagg gtctcatatc taacttcctc cttaaaacag agaaggtcaa     2760

tctagttcca gagggttgag gcaggtgcca ataattacat ctttggagag gatttgattt     2820

ctgcccaggg atttgctcac cccaaggtca tctgataatt tcacagatgc tgtgtaacag     2880

aacacagcca aagtaaactg tgtaggggag ccacatttac ataggaacca aatcaatgaa     2940

tttaggggtt acgattatag caatttaagg gcccaccaga agcaggcctc gaggagtcaa     3000

tttgcctctg tgtgcctcag tggagacaag tgggaaaaca tggtcccacc tgtgcgagac     3060

cccctgtcct gtgctgctca ctcaacaaca tctttgtgtt gctttcacca ggctgagacc     3120

ctaccctatg gggtatatgg gcttttacct gtgcaccagt gtgacaggaa agattcatgt     3180

cactactgtc cgtggctaca attcaaaggt atccaatgtc gctgtaaatt ttatggcact     3240

atttttattg gaggatttgg tcagaatgca gttgttgtac aactcataaa tactaactgc     3300

tgattttgac acatgtgtgc tccaaatgat ctggtggtta tttaacgtac ctcttaaaat     3360

tcgttgaaac gatttcaggt caactctgaa gagtatttga aagcaggact tcagaacagt     3420

gtttgatttt tattttataa atttaagcat tcaaattagg caaatctttg gctgcaggca     3480

gcaaaaacag ctggacttat ttaaaacaac ttgtttttga gttttcttat atatatattg     3540

attatttgtt ttacacacat gcagtagcac tttggtaaga gttaaagagt aaagcagctt     3600

atgttgtcag gtcgttctta tctagagaag agctatagca gatctcggac aaactcagaa     3660

tatattcact ttcatttttg acaggattcc ctccacaact cagtttcata tattattccg     3720

tattacattt ttgcagctaa attaccataa aatgtcagca aatgtaaaaa tttaatttct     3780

gaaaagcacc attagcccat ttcccccaaa ttaaacgtaa atgttttttt tcagcacatg     3840

ttaccatgtc tgacctgcaa aaatgctgga gaaaaatgaa ggaaaaaatt atgtttttca     3900

gtttaattct gttaactgaa gatattccaa ctcaaaacca gcctcatgct ctgattagat     3960

aatcttttac attgaacctt tactctcaaa gccatgtgtg gagggggctt gtcactattg     4020

taggctcact ggattggtca tttagagttt cacagactct taccagcata tatagtattt     4080

aattgtttca aaaaaaatca aactgtagtt gttttggcga taggtctcac gcaacacatt     4140

tttgtatgtg tgtgtgtgtg cgtgtgtgtg tgtgtgtgtg aaaaattgca ttcattgact     4200

tcaggtagat taaggtatct ttttattcat tgccctcagg aaagttaagg tatcaatgag     4260

acccttaagc caatcatgta ataactgcat gtgtctggtc caggagaagt attgaataag     4320

ccatttctac tgcttactca tgtccctatt tatgatttca acatggatac atatttcagt     4380

tctttctttt tctcactatc tgaaaataca tttccctccc tctcttcccc ccaatatctc     4440

cctttttttc tctcttcctc tatcttccaa accccacttt ctccctcctc cttttcctgt     4500

gttctcttaa gcagatagca cataccccca cccagtacca aatttcagaa cacaagaagg     4560

tccagttctt cccccttcac ataaaggaac atggtttgtc agcctttctc ctgtttatgg     4620

gtttcttcca gcagaacaga gacattgcca accatattgg atctgcttgc tgtccaaacc     4680

agcaaacttt cctgggcaaa tcacaatcag tgagtaaata gacagccttt ctgctgcctt     4740

gggtttctgt gcagataaac agaaatgctc tgattagaaa ggaaatgaat ggttccactc     4800

aaatgtcctg caatttagga ttgcagattt ctgccttgaa atacctgttt ctttgggaca     4860

ttccgtcctg atgattttta tttttgttgg tttttatttt tggggggaat gacatgtttg     4920

ggtcttttat acatgaaaat ttgtttgaca ataatctcac aaaacatatt ttacatctga     4980

acaaaatgcc tttttgttta ccgtagcgta tacatttgtt ttgggatttt tgtgtgtttg     5040

ttgggaattt tgtttttagc caggtcagta ttgatgaggc tgatcatttg gctctttttt     5100

tccttccaga agagttgcat caacaaagtt aattgtattt atgtatgtaa atagatttta     5160

agcttcatta taaaatattg ttaatgccta taactttttt tcaatttttt tgtgtgtgtt     5220

tctaaggact ttttcttagg tttgctaaat actgtaggga aaaaaatgct tctttctact     5280

ttgtttattt tagactttaa aatgagctac ttcttattca cttttgtaaa cagctaatag     5340

catggttcca atttttttta agttcacttt ttttgttcta ggggaaatga atgtgcaaaa     5400

aaagaaaaag aactgttggt tatttgtgtt attctggatg tataaaaatc aatggaaaaa     5460

aataaacttt caaattgaaa tgacggtata acacatctac tgaaaaagca acgggaaatg     5520

tggtcctatt taagccagcc cccacctagg gtctatttgt gtggcagtta ttgggtttgg     5580

tcacaaaaca tcctgaaaat tcgtgcgtgg gcttctttct ccctggtaca aacgtatgga     5640

atgcttctta aaggggaact gtcaagctgg tgtcttcagc cagatgacat gagagaatat     5700

cccagaaccc tctctccaag gtgtttctag atagcacagg agagcaggca ctgcactgtc     5760

cacagtccac ggtacacagt cgggtgggcc gcctcccctc tcctgggagc attcgtcgtg     5820

cccagcctga gcagggcagc tggactgctg ctgttcagga gccaccagag ccttcctctc     5880

tttgtaccac agtttcttct gtaaatccag tgttacaatc agtgtgaatg gcaaataaac     5940

agtttgacaa gtacatacac cata                                            5964


<210>  22
<211>  6078
<212>  DNA
<213>  Homo sapiens

<400>  22
gtaatttggg ttgtgtgaaa acttctttgg gcctcataaa caaccacaga accacaagtt       60

gggtagcctg gcagtgtcag aagtctgaac ccagcatagt ggtcagcagg caggacgaat      120

cacactgaat gcaaaccaca gggtttcgca gcgtggtgag catcaccaac ccacagccaa      180

ggcggcgctg gctttttttt tttttttaat ctttaacaat ttgaatattt gtttttacaa      240

aggtaaaaga aatcattgag tcccccgcct tcagaagagg gtgcattttc aggaggaagc      300

gatggcttca gacagcatat ttgagtcatt tccttcgtac ccacagtgct tcatgagaga      360

atgcatactt ggaatgaatc cttctagaga cgtccacgat gccagcacga gccgccgctt      420

cacgccgcct tccaccgcgc tgagcccagg caagatgagc gaggcgttgc cgctgggcgc      480

cccggacgcc ggcgctgccc tggccggcaa gctgaggagc ggcgaccgca gcatggtgga      540

ggtgctggcc gaccacccgg gcgagctggt gcgcaccgac agccccaact tcctctgctc      600

cgtgctgcct acgcactggc gctgcaacaa gaccctgccc atcgctttca aggtggtggc      660

cctaggggat gttccagatg gcactctggt cactgtgatg gctggcaatg atgaaaacta      720

ctcggctgag ctgagaaatg ctaccgcagc catgaagaac caggttgcaa gatttaatga      780

cctcaggttt gtcggtcgaa gtggaagagg gaaaagcttc actctgacca tcactgtctt      840

cacaaaccca ccgcaagtcg ccacctacca cagagccatc aaaatcacag tggatgggcc      900

ccgagaacct cgaagacatc ggcagaaact agatgatcag accaagcccg ggagcttgtc      960

cttttccgag cggctcagtg aactggagca gctgcggcgc acagccatga gggtcagccc     1020

acaccaccca gcccccacgc ccaaccctcg tgcctccctg aaccactcca ctgcctttaa     1080

ccctcagcct cagagtcaga tgcaggatac aaggcagatc caaccatccc caccgtggtc     1140

ctacgatcag tcctaccaat acctgggatc cattgcctct ccttctgtgc acccagcaac     1200

gcccatttca cctggacgtg ccagcggcat gacaaccctc tctgcagaac tttccagtcg     1260

actctcaacg gcacccgacc tgacagcgtt cagcgacccg cgccagttcc ccgcgctgcc     1320

ctccatctcc gacccccgca tgcactatcc aggcgccttc acctactccc cgacgccggt     1380

cacctcgggc atcggcatcg gcatgtcggc catgggctcg gccacgcgct accacaccta     1440

cctgccgccg ccctaccccg gctcgtcgca agcgcaggga ggcccgttcc aagccagctc     1500

gccctcctac cacctgtact acggcgcctc ggccggctcc taccagttct ccatggtggg     1560

cggcgagcgc tcgccgccgc gcatcctgcc gccctgcacc aacgcctcca ccggctccgc     1620

gctgctcaac cccagcctcc cgaaccagag cgacgtggtg gaggccgagg gcagccacag     1680

caactccccc accaacatgg cgccctccgc gcgcctggag gaggccgtgt ggaggcccta     1740

ctgaggcgcc aggcctggcc cggctgggcc ccgcgggccg ccgccttcgc ctccgggcgc     1800

gcgggcctcc tgttcgcgac aagcccgccg ggatcccggg ccctgggccc ggccaccgtc     1860

ctggggccga gggcgcccga cggccaggat ctcgctgtag gtcaggcccg cgcagcctcc     1920

tgcgcccaga agcccacgcc gccgccgtct gctggcgccc cggccctcgc ggaggtgtcc     1980

gaggcgacgc acctcgaggg tgtccgccgg ccccagcacc caggggacgc gctggaaagc     2040

aaacaggaag attcccggag ggaaactgtg aatgcttctg atttagcaat gctgtgaata     2100

aaaagaaaga ttttataccc ttgacttaac tttttaacca agttgtttat tccaaagagt     2160

gtggaatttt ggttggggtg gggggagagg agggatgcaa ctcgccctgt ttggcatcta     2220

attcttattt ttaatttttc cgcaccttat caattgcaaa atgcgtattt gcatttgggt     2280

ggtttttatt tttatatacg tttatataaa tatatataaa ttgagcttgc ttctttcttg     2340

ctttgaccat ggaaagaaat atgattccct tttctttaag ttttatttaa cttttctttt     2400

ggacttttgg gtagttgttt ttttttgttt tgttttgttt ttttgagaaa cagctacagc     2460

tttgggtcat ttttaactac tgtattccca caaggaatcc ccagatattt atgtatcttg     2520

atgttcagac atttatgtgt tgataatttt ttaattattt aaatgtactt atattaagaa     2580

aaatatcaag tactacattt tcttttgttc ttgatagtag ccaaagttaa atgtatcaca     2640

ttgaagaagg ctagaaaaaa agaatgagta atgtgatcgc ttggttatcc agaagtattg     2700

tttacattaa actccctttc atgttaatca aacaagtgag tagctcacgc agcaacgttt     2760

ttaataggat ttttagacac tgagggtcac tccaaggatc agaagtatgg aattttctgc     2820

caggctcaac aagggtctca tatctaactt cctccttaaa acagagaagg tcaatctagt     2880

tccagagggt tgaggcaggt gccaataatt acatctttgg agaggatttg atttctgccc     2940

agggatttgc tcaccccaag gtcatctgat aatttcacag atgctgtgta acagaacaca     3000

gccaaagtaa actgtgtagg ggagccacat ttacatagga accaaatcaa tgaatttagg     3060

ggttacgatt atagcaattt aagggcccac cagaagcagg cctcgaggag tcaatttgcc     3120

tctgtgtgcc tcagtggaga caagtgggaa aacatggtcc cacctgtgcg agaccccctg     3180

tcctgtgctg ctcactcaac aacatctttg tgttgctttc accaggctga gaccctaccc     3240

tatggggtat atgggctttt acctgtgcac cagtgtgaca ggaaagattc atgtcactac     3300

tgtccgtggc tacaattcaa aggtatccaa tgtcgctgta aattttatgg cactattttt     3360

attggaggat ttggtcagaa tgcagttgtt gtacaactca taaatactaa ctgctgattt     3420

tgacacatgt gtgctccaaa tgatctggtg gttatttaac gtacctctta aaattcgttg     3480

aaacgatttc aggtcaactc tgaagagtat ttgaaagcag gacttcagaa cagtgtttga     3540

tttttatttt ataaatttaa gcattcaaat taggcaaatc tttggctgca ggcagcaaaa     3600

acagctggac ttatttaaaa caacttgttt ttgagttttc ttatatatat attgattatt     3660

tgttttacac acatgcagta gcactttggt aagagttaaa gagtaaagca gcttatgttg     3720

tcaggtcgtt cttatctaga gaagagctat agcagatctc ggacaaactc agaatatatt     3780

cactttcatt tttgacagga ttccctccac aactcagttt catatattat tccgtattac     3840

atttttgcag ctaaattacc ataaaatgtc agcaaatgta aaaatttaat ttctgaaaag     3900

caccattagc ccatttcccc caaattaaac gtaaatgttt tttttcagca catgttacca     3960

tgtctgacct gcaaaaatgc tggagaaaaa tgaaggaaaa aattatgttt ttcagtttaa     4020

ttctgttaac tgaagatatt ccaactcaaa accagcctca tgctctgatt agataatctt     4080

ttacattgaa cctttactct caaagccatg tgtggagggg gcttgtcact attgtaggct     4140

cactggattg gtcatttaga gtttcacaga ctcttaccag catatatagt atttaattgt     4200

ttcaaaaaaa atcaaactgt agttgttttg gcgataggtc tcacgcaaca catttttgta     4260

tgtgtgtgtg tgtgcgtgtg tgtgtgtgtg tgtgaaaaat tgcattcatt gacttcaggt     4320

agattaaggt atctttttat tcattgccct caggaaagtt aaggtatcaa tgagaccctt     4380

aagccaatca tgtaataact gcatgtgtct ggtccaggag aagtattgaa taagccattt     4440

ctactgctta ctcatgtccc tatttatgat ttcaacatgg atacatattt cagttctttc     4500

tttttctcac tatctgaaaa tacatttccc tccctctctt ccccccaata tctccctttt     4560

tttctctctt cctctatctt ccaaacccca ctttctccct cctccttttc ctgtgttctc     4620

ttaagcagat agcacatacc cccacccagt accaaatttc agaacacaag aaggtccagt     4680

tcttccccct tcacataaag gaacatggtt tgtcagcctt tctcctgttt atgggtttct     4740

tccagcagaa cagagacatt gccaaccata ttggatctgc ttgctgtcca aaccagcaaa     4800

ctttcctggg caaatcacaa tcagtgagta aatagacagc ctttctgctg ccttgggttt     4860

ctgtgcagat aaacagaaat gctctgatta gaaaggaaat gaatggttcc actcaaatgt     4920

cctgcaattt aggattgcag atttctgcct tgaaatacct gtttctttgg gacattccgt     4980

cctgatgatt tttatttttg ttggttttta tttttggggg gaatgacatg tttgggtctt     5040

ttatacatga aaatttgttt gacaataatc tcacaaaaca tattttacat ctgaacaaaa     5100

tgcctttttg tttaccgtag cgtatacatt tgttttggga tttttgtgtg tttgttggga     5160

attttgtttt tagccaggtc agtattgatg aggctgatca tttggctctt tttttccttc     5220

cagaagagtt gcatcaacaa agttaattgt atttatgtat gtaaatagat tttaagcttc     5280

attataaaat attgttaatg cctataactt tttttcaatt tttttgtgtg tgtttctaag     5340

gactttttct taggtttgct aaatactgta gggaaaaaaa tgcttctttc tactttgttt     5400

attttagact ttaaaatgag ctacttctta ttcacttttg taaacagcta atagcatggt     5460

tccaattttt tttaagttca ctttttttgt tctaggggaa atgaatgtgc aaaaaaagaa     5520

aaagaactgt tggttatttg tgttattctg gatgtataaa aatcaatgga aaaaaataaa     5580

ctttcaaatt gaaatgacgg tataacacat ctactgaaaa agcaacggga aatgtggtcc     5640

tatttaagcc agcccccacc tagggtctat ttgtgtggca gttattgggt ttggtcacaa     5700

aacatcctga aaattcgtgc gtgggcttct ttctccctgg tacaaacgta tggaatgctt     5760

cttaaagggg aactgtcaag ctggtgtctt cagccagatg acatgagaga atatcccaga     5820

accctctctc caaggtgttt ctagatagca caggagagca ggcactgcac tgtccacagt     5880

ccacggtaca cagtcgggtg ggccgcctcc cctctcctgg gagcattcgt cgtgcccagc     5940

ctgagcaggg cagctggact gctgctgttc aggagccacc agagccttcc tctctttgta     6000

ccacagtttc ttctgtaaat ccagtgttac aatcagtgtg aatggcaaat aaacagtttg     6060

acaagtacat acaccata                                                   6078


<210>  23
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Ser Asn Ser Leu Phe Ser Thr Val Thr Pro Cys Gln Gln Asn 
1               5                   10                  15      


Phe Phe Trp Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro Ser Ser 
            20                  25                  30          


Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val Ala Ala 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Glu Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Arg Leu Arg Pro Pro 
                85                  90                  95      


His Asp Asn Arg Thr Met Val Glu Ile Ile Ala Asp His Pro Ala Glu 
            100                 105                 110         


Leu Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Ser 
        115                 120                 125             


His Trp Arg Cys Asn Lys Thr Leu Pro Val Ala Phe Lys Val Val Ala 
    130                 135                 140                 


Leu Gly Glu Val Pro Asp Gly Thr Val Val Thr Val Met Ala Gly Asn 
145                 150                 155                 160 


Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Ser Ala Val Met Lys 
                165                 170                 175     


Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly 
            180                 185                 190         


Arg Gly Lys Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro 
        195                 200                 205             


Gln Val Ala Thr Tyr His Arg Ala Ile Lys Val Thr Val Asp Gly Pro 
    210                 215                 220                 


Arg Glu Pro Arg Arg His Arg Gln Lys Leu Asp Asp Ser Lys Pro Ser 
225                 230                 235                 240 


Leu Phe Ser Asp Arg Leu Ser Asp Leu Gly Arg Ile Pro His Pro Ser 
                245                 250                 255     


Met Arg Val Gly Val Pro Pro Gln Asn Pro Arg Pro Ser Leu Asn Ser 
            260                 265                 270         


Ala Pro Ser Pro Phe Asn Pro Gln Gly Gln Ser Gln Ile Thr Asp Pro 
        275                 280                 285             


Arg Gln Ala Gln Ser Ser Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Pro 
    290                 295                 300                 


Ser Tyr Leu Ser Gln Met Thr Ser Pro Ser Ile His Ser Thr Thr Pro 
305                 310                 315                 320 


Leu Ser Ser Thr Arg Gly Thr Gly Leu Pro Ala Ile Thr Asp Val Pro 
                325                 330                 335     


Arg Arg Ile Ser Asp Asp Asp Thr Ala Thr Ser Asp Phe Cys Leu Trp 
            340                 345                 350         


Pro Ser Thr Leu Ser Lys Lys Ser Gln Ala Gly Ala Ser Glu Leu Gly 
        355                 360                 365             


Pro Phe Ser Asp Pro Arg Gln Phe Pro Ser Ile Ser Ser Leu Thr Glu 
    370                 375                 380                 


Ser Arg Phe Ser Asn Pro Arg Met His Tyr Pro Ala Thr Phe Thr Tyr 
385                 390                 395                 400 


Thr Pro Pro Val Thr Ser Gly Met Ser Leu Gly Met Ser Ala Thr Thr 
                405                 410                 415     


His Tyr His Thr Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ser 
            420                 425                 430         


Gln Ser Gly Pro Phe Gln Thr Ser Ser Thr Pro Tyr Leu Tyr Tyr Gly 
        435                 440                 445             


Thr Ser Ser Gly Ser Tyr Gln Phe Pro Met Val Pro Gly Gly Asp Arg 
    450                 455                 460                 


Ser Pro Ser Arg Met Leu Pro Pro Cys Thr Thr Thr Ser Asn Gly Ser 
465                 470                 475                 480 


Thr Leu Leu Asn Pro Asn Leu Pro Asn Gln Asn Asp Gly Val Asp Ala 
                485                 490                 495     


Asp Gly Ser His Ser Ser Ser Pro Thr Val Leu Asn Ser Ser Gly Arg 
            500                 505                 510         


Met Asp Glu Ser Val Trp Arg Pro Tyr 
        515                 520     


<210>  24
<211>  499
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Ser Asn Ser Leu Phe Ser Thr Val Thr Pro Cys Gln Gln Asn 
1               5                   10                  15      


Phe Phe Trp Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro Ser Ser 
            20                  25                  30          


Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val Ala Ala 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Glu Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Arg Leu Arg Pro Pro 
                85                  90                  95      


His Asp Asn Arg Thr Met Val Glu Ile Ile Ala Asp His Pro Ala Glu 
            100                 105                 110         


Leu Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Ser 
        115                 120                 125             


His Trp Arg Cys Asn Lys Thr Leu Pro Val Ala Phe Lys Val Val Ala 
    130                 135                 140                 


Leu Gly Glu Val Pro Asp Gly Thr Val Val Thr Val Met Ala Gly Asn 
145                 150                 155                 160 


Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Ser Ala Val Met Lys 
                165                 170                 175     


Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly 
            180                 185                 190         


Arg Gly Lys Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro 
        195                 200                 205             


Gln Val Ala Thr Tyr His Arg Ala Ile Lys Val Thr Val Asp Gly Pro 
    210                 215                 220                 


Arg Glu Pro Arg Arg His Arg Gln Lys Leu Asp Asp Ser Lys Pro Ser 
225                 230                 235                 240 


Leu Phe Ser Asp Arg Leu Ser Asp Leu Gly Arg Ile Pro His Pro Ser 
                245                 250                 255     


Met Arg Val Gly Val Pro Pro Gln Asn Pro Arg Pro Ser Leu Asn Ser 
            260                 265                 270         


Ala Pro Ser Pro Phe Asn Pro Gln Gly Gln Ser Gln Ile Thr Asp Pro 
        275                 280                 285             


Arg Gln Ala Gln Ser Ser Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Pro 
    290                 295                 300                 


Ser Tyr Leu Ser Gln Met Thr Ser Pro Ser Ile His Ser Thr Thr Pro 
305                 310                 315                 320 


Leu Ser Ser Thr Arg Gly Thr Gly Leu Pro Ala Ile Thr Asp Val Pro 
                325                 330                 335     


Arg Arg Ile Ser Gly Ala Ser Glu Leu Gly Pro Phe Ser Asp Pro Arg 
            340                 345                 350         


Gln Phe Pro Ser Ile Ser Ser Leu Thr Glu Ser Arg Phe Ser Asn Pro 
        355                 360                 365             


Arg Met His Tyr Pro Ala Thr Phe Thr Tyr Thr Pro Pro Val Thr Ser 
    370                 375                 380                 


Gly Met Ser Leu Gly Met Ser Ala Thr Thr His Tyr His Thr Tyr Leu 
385                 390                 395                 400 


Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ser Gln Ser Gly Pro Phe Gln 
                405                 410                 415     


Thr Ser Ser Thr Pro Tyr Leu Tyr Tyr Gly Thr Ser Ser Gly Ser Tyr 
            420                 425                 430         


Gln Phe Pro Met Val Pro Gly Gly Asp Arg Ser Pro Ser Arg Met Leu 
        435                 440                 445             


Pro Pro Cys Thr Thr Thr Ser Asn Gly Ser Thr Leu Leu Asn Pro Asn 
    450                 455                 460                 


Leu Pro Asn Gln Asn Asp Gly Val Asp Ala Asp Gly Ser His Ser Ser 
465                 470                 475                 480 


Ser Pro Thr Val Leu Asn Ser Ser Gly Arg Met Asp Glu Ser Val Trp 
                485                 490                 495     


Arg Pro Tyr 
            


<210>  25
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Ser Asn Ser Leu Phe Ser Thr Val Thr Pro Cys Gln Gln Asn 
1               5                   10                  15      


Phe Phe Trp Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro Ser Ser 
            20                  25                  30          


Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val Ala Ala 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Glu Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Arg Leu Arg Pro Pro 
                85                  90                  95      


His Asp Asn Arg Thr Met Val Glu Ile Ile Ala Asp His Pro Ala Glu 
            100                 105                 110         


Leu Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu Pro Ser 
        115                 120                 125             


His Trp Arg Cys Asn Lys Thr Leu Pro Val Ala Phe Lys Val Val Ala 
    130                 135                 140                 


Leu Gly Glu Val Pro Asp Gly Thr Val Val Thr Val Met Ala Gly Asn 
145                 150                 155                 160 


Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Ser Ala Val Met Lys 
                165                 170                 175     


Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg Ser Gly 
            180                 185                 190         


Arg Gly Lys Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn Pro Pro 
        195                 200                 205             


Gln Val Ala Thr Tyr His Arg Ala Ile Lys Val Thr Val Asp Gly Pro 
    210                 215                 220                 


Arg Glu Pro Arg Arg His Arg Gln Lys Leu Asp Asp Ser Lys Pro Ser 
225                 230                 235                 240 


Leu Phe Ser Asp Arg Leu Ser Asp Leu Gly Arg Ile Pro His Pro Ser 
                245                 250                 255     


Met Arg Val Gly Val Pro Pro Gln Asn Pro Arg Pro Ser Leu Asn Ser 
            260                 265                 270         


Ala Pro Ser Pro Phe Asn Pro Gln Gly Gln Ser Gln Ile Thr Asp Pro 
        275                 280                 285             


Arg Gln Ala Gln Ser Ser Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Pro 
    290                 295                 300                 


Ser Tyr Leu Ser Gln Met Thr Ser Pro Ser Ile His Ser Thr Thr Pro 
305                 310                 315                 320 


Leu Ser Ser Thr Arg Gly Thr Gly Leu Pro Ala Ile Thr Asp Val Pro 
                325                 330                 335     


Arg Arg Ile Ser Asp Asp Asp Thr Ala Thr Ser Asp Phe Cys Leu Trp 
            340                 345                 350         


Pro Ser Thr Leu Ser Lys Lys Ser Gln Ala Gly Ala Ser Glu Leu Gly 
        355                 360                 365             


Pro Phe Ser Asp Pro Arg Gln Phe Pro Ser Ile Ser Ser Leu Thr Glu 
    370                 375                 380                 


Ser Arg Phe Ser Asn Pro Arg Met His Tyr Pro Ala Thr Phe Thr Tyr 
385                 390                 395                 400 


Thr Pro Pro Val Thr Ser Gly Met Ser Leu Gly Met Ser Ala Thr Thr 
                405                 410                 415     


His Tyr His Thr Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ser 
            420                 425                 430         


Gln Ser Gly Pro Phe Gln Thr Ser Ser Thr Pro Tyr Leu Tyr Tyr Gly 
        435                 440                 445             


Thr Ser Ser Gly Ser Tyr Gln Phe Pro Met Val Pro Gly Gly Asp Arg 
    450                 455                 460                 


Ser Pro Ser Arg Met Leu Pro Pro Cys Thr Thr Thr Ser Asn Gly Ser 
465                 470                 475                 480 


Thr Leu Leu Asn Pro Asn Leu Pro Asn Gln Asn Asp Gly Val Asp Ala 
                485                 490                 495     


Asp Gly Ser His Ser Ser Ser Pro Thr Val Leu Asn Ser Ser Gly Arg 
            500                 505                 510         


Met Asp Glu Ser Val Trp Arg Pro Tyr 
        515                 520     


<210>  26
<211>  485
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Arg Ile Pro Val Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro 
1               5                   10                  15      


Ser Ser Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val 
            20                  25                  30          


Ala Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Ala Ala Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Arg Leu Arg 
65                  70                  75                  80  


Pro Pro His Asp Asn Arg Thr Met Val Glu Ile Ile Ala Asp His Pro 
                85                  90                  95      


Ala Glu Leu Val Arg Thr Asp Ser Pro Asn Phe Leu Cys Ser Val Leu 
            100                 105                 110         


Pro Ser His Trp Arg Cys Asn Lys Thr Leu Pro Val Ala Phe Lys Val 
        115                 120                 125             


Val Ala Leu Gly Glu Val Pro Asp Gly Thr Val Val Thr Val Met Ala 
    130                 135                 140                 


Gly Asn Asp Glu Asn Tyr Ser Ala Glu Leu Arg Asn Ala Ser Ala Val 
145                 150                 155                 160 


Met Lys Asn Gln Val Ala Arg Phe Asn Asp Leu Arg Phe Val Gly Arg 
                165                 170                 175     


Ser Gly Arg Gly Lys Ser Phe Thr Leu Thr Ile Thr Val Phe Thr Asn 
            180                 185                 190         


Pro Pro Gln Val Ala Thr Tyr His Arg Ala Ile Lys Val Thr Val Asp 
        195                 200                 205             


Gly Pro Arg Glu Pro Arg Arg His Arg Gln Lys Leu Asp Asp Ser Lys 
    210                 215                 220                 


Pro Ser Leu Phe Ser Asp Arg Leu Ser Asp Leu Gly Arg Ile Pro His 
225                 230                 235                 240 


Pro Ser Met Arg Val Gly Val Pro Pro Gln Asn Pro Arg Pro Ser Leu 
                245                 250                 255     


Asn Ser Ala Pro Ser Pro Phe Asn Pro Gln Gly Gln Ser Gln Ile Thr 
            260                 265                 270         


Asp Pro Arg Gln Ala Gln Ser Ser Pro Pro Trp Ser Tyr Asp Gln Ser 
        275                 280                 285             


Tyr Pro Ser Tyr Leu Ser Gln Met Thr Ser Pro Ser Ile His Ser Thr 
    290                 295                 300                 


Thr Pro Leu Ser Ser Thr Arg Gly Thr Gly Leu Pro Ala Ile Thr Asp 
305                 310                 315                 320 


Val Pro Arg Arg Ile Ser Gly Ala Ser Glu Leu Gly Pro Phe Ser Asp 
                325                 330                 335     


Pro Arg Gln Phe Pro Ser Ile Ser Ser Leu Thr Glu Ser Arg Phe Ser 
            340                 345                 350         


Asn Pro Arg Met His Tyr Pro Ala Thr Phe Thr Tyr Thr Pro Pro Val 
        355                 360                 365             


Thr Ser Gly Met Ser Leu Gly Met Ser Ala Thr Thr His Tyr His Thr 
    370                 375                 380                 


Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ser Gln Ser Gly Pro 
385                 390                 395                 400 


Phe Gln Thr Ser Ser Thr Pro Tyr Leu Tyr Tyr Gly Thr Ser Ser Gly 
                405                 410                 415     


Ser Tyr Gln Phe Pro Met Val Pro Gly Gly Asp Arg Ser Pro Ser Arg 
            420                 425                 430         


Met Leu Pro Pro Cys Thr Thr Thr Ser Asn Gly Ser Thr Leu Leu Asn 
        435                 440                 445             


Pro Asn Leu Pro Asn Gln Asn Asp Gly Val Asp Ala Asp Gly Ser His 
    450                 455                 460                 


Ser Ser Ser Pro Thr Val Leu Asn Ser Ser Gly Arg Met Asp Glu Ser 
465                 470                 475                 480 


Val Trp Arg Pro Tyr 
                485 


<210>  27
<211>  514
<212>  PRT
<213>  Mus musculus

<400>  27

Met Arg Ile Pro Val Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro 
1               5                   10                  15      


Ser Ser Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val 
            20                  25                  30          


Ala Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Val Pro Arg Leu Arg Pro Pro His Asp Asn Arg Thr Met Val 
                85                  90                  95      


Glu Ile Ile Ala Asp His Pro Ala Glu Leu Val Arg Thr Asp Ser Pro 
            100                 105                 110         


Asn Phe Leu Cys Ser Val Leu Pro Ser His Trp Arg Cys Asn Lys Thr 
        115                 120                 125             


Leu Pro Val Ala Phe Lys Val Val Ala Leu Gly Glu Val Pro Asp Gly 
    130                 135                 140                 


Thr Val Val Thr Val Met Ala Gly Asn Asp Glu Asn Tyr Ser Ala Glu 
145                 150                 155                 160 


Leu Arg Asn Ala Ser Ala Val Met Lys Asn Gln Val Ala Arg Phe Asn 
                165                 170                 175     


Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys Ser Phe Thr Leu 
            180                 185                 190         


Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala Thr Tyr His Arg 
        195                 200                 205             


Ala Ile Lys Val Thr Val Asp Gly Pro Arg Glu Pro Arg Arg His Arg 
    210                 215                 220                 


Gln Lys Leu Asp Asp Ser Lys Pro Ser Leu Phe Ser Asp Arg Leu Ser 
225                 230                 235                 240 


Asp Leu Gly Arg Ile Pro His Pro Ser Met Arg Val Gly Val Pro Pro 
                245                 250                 255     


Gln Asn Pro Arg Pro Ser Leu Asn Ser Ala Pro Ser Pro Phe Asn Pro 
            260                 265                 270         


Gln Gly Gln Ser Gln Ile Thr Asp Pro Arg Gln Ala Gln Ser Ser Pro 
        275                 280                 285             


Pro Trp Ser Tyr Asp Gln Ser Tyr Pro Ser Tyr Leu Ser Gln Met Thr 
    290                 295                 300                 


Ser Pro Ser Ile His Ser Thr Thr Pro Leu Ser Ser Thr Arg Gly Thr 
305                 310                 315                 320 


Gly Leu Pro Ala Ile Thr Asp Val Pro Arg Arg Ile Ser Asp Asp Asp 
                325                 330                 335     


Thr Ala Thr Ser Asp Phe Cys Leu Trp Pro Ser Ser Leu Ser Lys Lys 
            340                 345                 350         


Ser Gln Ala Gly Ala Ser Glu Leu Gly Pro Phe Ser Asp Pro Arg Gln 
        355                 360                 365             


Phe Pro Ser Ile Ser Ser Leu Thr Glu Ser Arg Phe Ser Asn Pro Arg 
    370                 375                 380                 


Met His Tyr Pro Ala Thr Phe Thr Tyr Thr Pro Pro Val Thr Ser Gly 
385                 390                 395                 400 


Met Ser Leu Gly Met Ser Ala Thr Thr His Tyr His Thr Tyr Leu Pro 
                405                 410                 415     


Pro Pro Tyr Pro Gly Ser Ser Gln Ser Gln Ser Gly Pro Phe Gln Thr 
            420                 425                 430         


Ser Ser Thr Pro Tyr Leu Tyr Tyr Gly Thr Ser Ser Ala Ser Tyr Gln 
        435                 440                 445             


Phe Pro Met Val Pro Gly Gly Asp Arg Ser Pro Ser Arg Met Val Pro 
    450                 455                 460                 


Pro Cys Thr Thr Thr Ser Asn Gly Ser Thr Leu Leu Asn Pro Asn Leu 
465                 470                 475                 480 


Pro Asn Gln Asn Asp Gly Val Asp Ala Asp Gly Ser His Ser Ser Ser 
                485                 490                 495     


Pro Thr Val Leu Asn Ser Ser Gly Arg Met Asp Glu Ser Val Trp Arg 
            500                 505                 510         


Pro Tyr 
        


<210>  28
<211>  528
<212>  PRT
<213>  Mus musculus

<400>  28

Met Ala Ser Asn Ser Leu Phe Ser Ala Val Thr Pro Cys Gln Gln Ser 
1               5                   10                  15      


Phe Phe Trp Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro Ser Ser 
            20                  25                  30          


Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val Ala Ala 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Val Pro Arg Leu Arg Pro Pro His Asp Asn Arg Thr Met Val Glu Ile 
            100                 105                 110         


Ile Ala Asp His Pro Ala Glu Leu Val Arg Thr Asp Ser Pro Asn Phe 
        115                 120                 125             


Leu Cys Ser Val Leu Pro Ser His Trp Arg Cys Asn Lys Thr Leu Pro 
    130                 135                 140                 


Val Ala Phe Lys Val Val Ala Leu Gly Glu Val Pro Asp Gly Thr Val 
145                 150                 155                 160 


Val Thr Val Met Ala Gly Asn Asp Glu Asn Tyr Ser Ala Glu Leu Arg 
                165                 170                 175     


Asn Ala Ser Ala Val Met Lys Asn Gln Val Ala Arg Phe Asn Asp Leu 
            180                 185                 190         


Arg Phe Val Gly Arg Ser Gly Arg Gly Lys Ser Phe Thr Leu Thr Ile 
        195                 200                 205             


Thr Val Phe Thr Asn Pro Pro Gln Val Ala Thr Tyr His Arg Ala Ile 
    210                 215                 220                 


Lys Val Thr Val Asp Gly Pro Arg Glu Pro Arg Arg His Arg Gln Lys 
225                 230                 235                 240 


Leu Asp Asp Ser Lys Pro Ser Leu Phe Ser Asp Arg Leu Ser Asp Leu 
                245                 250                 255     


Gly Arg Ile Pro His Pro Ser Met Arg Val Gly Val Pro Pro Gln Asn 
            260                 265                 270         


Pro Arg Pro Ser Leu Asn Ser Ala Pro Ser Pro Phe Asn Pro Gln Gly 
        275                 280                 285             


Gln Ser Gln Ile Thr Asp Pro Arg Gln Ala Gln Ser Ser Pro Pro Trp 
    290                 295                 300                 


Ser Tyr Asp Gln Ser Tyr Pro Ser Tyr Leu Ser Gln Met Thr Ser Pro 
305                 310                 315                 320 


Ser Ile His Ser Thr Thr Pro Leu Ser Ser Thr Arg Gly Thr Gly Leu 
                325                 330                 335     


Pro Ala Ile Thr Asp Val Pro Arg Arg Ile Ser Asp Asp Asp Thr Ala 
            340                 345                 350         


Thr Ser Asp Phe Cys Leu Trp Pro Ser Ser Leu Ser Lys Lys Ser Gln 
        355                 360                 365             


Ala Gly Ala Ser Glu Leu Gly Pro Phe Ser Asp Pro Arg Gln Phe Pro 
    370                 375                 380                 


Ser Ile Ser Ser Leu Thr Glu Ser Arg Phe Ser Asn Pro Arg Met His 
385                 390                 395                 400 


Tyr Pro Ala Thr Phe Thr Tyr Thr Pro Pro Val Thr Ser Gly Met Ser 
                405                 410                 415     


Leu Gly Met Ser Ala Thr Thr His Tyr His Thr Tyr Leu Pro Pro Pro 
            420                 425                 430         


Tyr Pro Gly Ser Ser Gln Ser Gln Ser Gly Pro Phe Gln Thr Ser Ser 
        435                 440                 445             


Thr Pro Tyr Leu Tyr Tyr Gly Thr Ser Ser Ala Ser Tyr Gln Phe Pro 
    450                 455                 460                 


Met Val Pro Gly Gly Asp Arg Ser Pro Ser Arg Met Val Pro Pro Cys 
465                 470                 475                 480 


Thr Thr Thr Ser Asn Gly Ser Thr Leu Leu Asn Pro Asn Leu Pro Asn 
                485                 490                 495     


Gln Asn Asp Gly Val Asp Ala Asp Gly Ser His Ser Ser Ser Pro Thr 
            500                 505                 510         


Val Leu Asn Ser Ser Gly Arg Met Asp Glu Ser Val Trp Arg Pro Tyr 
        515                 520                 525             


<210>  29
<211>  528
<212>  PRT
<213>  Mus musculus

<400>  29

Met Ala Ser Asn Ser Leu Phe Ser Ala Val Thr Pro Cys Gln Gln Ser 
1               5                   10                  15      


Phe Phe Trp Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro Ser Ser 
            20                  25                  30          


Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val Ala Ala 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    50                  55                  60                  


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu Ala Ala 
65                  70                  75                  80  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
                85                  90                  95      


Val Pro Arg Leu Arg Pro Pro His Asp Asn Arg Thr Met Val Glu Ile 
            100                 105                 110         


Ile Ala Asp His Pro Ala Glu Leu Val Arg Thr Asp Ser Pro Asn Phe 
        115                 120                 125             


Leu Cys Ser Val Leu Pro Ser His Trp Arg Cys Asn Lys Thr Leu Pro 
    130                 135                 140                 


Val Ala Phe Lys Val Val Ala Leu Gly Glu Val Pro Asp Gly Thr Val 
145                 150                 155                 160 


Val Thr Val Met Ala Gly Asn Asp Glu Asn Tyr Ser Ala Glu Leu Arg 
                165                 170                 175     


Asn Ala Ser Ala Val Met Lys Asn Gln Val Ala Arg Phe Asn Asp Leu 
            180                 185                 190         


Arg Phe Val Gly Arg Ser Gly Arg Gly Lys Ser Phe Thr Leu Thr Ile 
        195                 200                 205             


Thr Val Phe Thr Asn Pro Pro Gln Val Ala Thr Tyr His Arg Ala Ile 
    210                 215                 220                 


Lys Val Thr Val Asp Gly Pro Arg Glu Pro Arg Arg His Arg Gln Lys 
225                 230                 235                 240 


Leu Asp Asp Ser Lys Pro Ser Leu Phe Ser Asp Arg Leu Ser Asp Leu 
                245                 250                 255     


Gly Arg Ile Pro His Pro Ser Met Arg Val Gly Val Pro Pro Gln Asn 
            260                 265                 270         


Pro Arg Pro Ser Leu Asn Ser Ala Pro Ser Pro Phe Asn Pro Gln Gly 
        275                 280                 285             


Gln Ser Gln Ile Thr Asp Pro Arg Gln Ala Gln Ser Ser Pro Pro Trp 
    290                 295                 300                 


Ser Tyr Asp Gln Ser Tyr Pro Ser Tyr Leu Ser Gln Met Thr Ser Pro 
305                 310                 315                 320 


Ser Ile His Ser Thr Thr Pro Leu Ser Ser Thr Arg Gly Thr Gly Leu 
                325                 330                 335     


Pro Ala Ile Thr Asp Val Pro Arg Arg Ile Ser Asp Asp Asp Thr Ala 
            340                 345                 350         


Thr Ser Asp Phe Cys Leu Trp Pro Ser Ser Leu Ser Lys Lys Ser Gln 
        355                 360                 365             


Ala Gly Ala Ser Glu Leu Gly Pro Phe Ser Asp Pro Arg Gln Phe Pro 
    370                 375                 380                 


Ser Ile Ser Ser Leu Thr Glu Ser Arg Phe Ser Asn Pro Arg Met His 
385                 390                 395                 400 


Tyr Pro Ala Thr Phe Thr Tyr Thr Pro Pro Val Thr Ser Gly Met Ser 
                405                 410                 415     


Leu Gly Met Ser Ala Thr Thr His Tyr His Thr Tyr Leu Pro Pro Pro 
            420                 425                 430         


Tyr Pro Gly Ser Ser Gln Ser Gln Ser Gly Pro Phe Gln Thr Ser Ser 
        435                 440                 445             


Thr Pro Tyr Leu Tyr Tyr Gly Thr Ser Ser Ala Ser Tyr Gln Phe Pro 
    450                 455                 460                 


Met Val Pro Gly Gly Asp Arg Ser Pro Ser Arg Met Val Pro Pro Cys 
465                 470                 475                 480 


Thr Thr Thr Ser Asn Gly Ser Thr Leu Leu Asn Pro Asn Leu Pro Asn 
                485                 490                 495     


Gln Asn Asp Gly Val Asp Ala Asp Gly Ser His Ser Ser Ser Pro Thr 
            500                 505                 510         


Val Leu Asn Ser Ser Gly Arg Met Asp Glu Ser Val Trp Arg Pro Tyr 
        515                 520                 525             


<210>  30
<211>  456
<212>  PRT
<213>  Mus musculus

<400>  30

Met Arg Ile Pro Val Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro 
1               5                   10                  15      


Ser Ser Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val 
            20                  25                  30          


Ala Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Val Pro Arg Leu Arg Pro Pro His Asp Asn Arg Thr Met Val 
                85                  90                  95      


Glu Ile Ile Ala Asp His Pro Ala Glu Leu Val Arg Thr Asp Ser Pro 
            100                 105                 110         


Asn Phe Leu Cys Ser Val Leu Pro Ser His Trp Arg Cys Asn Lys Thr 
        115                 120                 125             


Leu Pro Val Ala Phe Lys Val Val Ala Leu Gly Glu Val Pro Asp Gly 
    130                 135                 140                 


Thr Val Val Thr Val Met Ala Gly Asn Asp Glu Asn Tyr Ser Ala Glu 
145                 150                 155                 160 


Leu Arg Asn Ala Ser Ala Val Met Lys Asn Gln Val Ala Arg Phe Asn 
                165                 170                 175     


Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Gly Lys Ser Phe Thr Leu 
            180                 185                 190         


Thr Ile Thr Val Phe Thr Asn Pro Pro Gln Val Ala Thr Tyr His Arg 
        195                 200                 205             


Ala Ile Lys Val Thr Val Asp Gly Pro Arg Glu Pro Arg Asn Pro Arg 
    210                 215                 220                 


Gln Ala Gln Ser Ser Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Pro Ser 
225                 230                 235                 240 


Tyr Leu Ser Gln Met Thr Ser Pro Ser Ile His Ser Thr Thr Pro Leu 
                245                 250                 255     


Ser Ser Thr Arg Gly Thr Gly Leu Pro Ala Ile Thr Asp Val Pro Arg 
            260                 265                 270         


Arg Ile Ser Asp Asp Asp Thr Ala Thr Ser Asp Phe Cys Leu Trp Pro 
        275                 280                 285             


Ser Ser Leu Ser Lys Lys Ser Gln Ala Gly Ala Ser Glu Leu Gly Pro 
    290                 295                 300                 


Phe Ser Asp Pro Arg Gln Phe Pro Ser Ile Ser Ser Leu Thr Glu Ser 
305                 310                 315                 320 


Arg Phe Ser Asn Pro Arg Met His Tyr Pro Ala Thr Phe Thr Tyr Thr 
                325                 330                 335     


Pro Pro Val Thr Ser Gly Met Ser Leu Gly Met Ser Ala Thr Thr His 
            340                 345                 350         


Tyr His Thr Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ser Gln 
        355                 360                 365             


Ser Gly Pro Phe Gln Thr Ser Ser Thr Pro Tyr Leu Tyr Tyr Gly Thr 
    370                 375                 380                 


Ser Ser Ala Ser Tyr Gln Phe Pro Met Val Pro Gly Gly Asp Arg Ser 
385                 390                 395                 400 


Pro Ser Arg Met Val Pro Pro Cys Thr Thr Thr Ser Asn Gly Ser Thr 
                405                 410                 415     


Leu Leu Asn Pro Asn Leu Pro Asn Gln Asn Asp Gly Val Asp Ala Asp 
            420                 425                 430         


Gly Ser His Ser Ser Ser Pro Thr Val Leu Asn Ser Ser Gly Arg Met 
        435                 440                 445             


Asp Glu Ser Val Trp Arg Pro Tyr 
    450                 455     


<210>  31
<211>  421
<212>  PRT
<213>  Mus musculus

<400>  31

Met Arg Ile Pro Val Asp Pro Ser Thr Ser Arg Arg Phe Ser Pro Pro 
1               5                   10                  15      


Ser Ser Ser Leu Gln Pro Gly Lys Met Ser Asp Val Ser Pro Val Val 
            20                  25                  30          


Ala Ala Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Glu 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
65                  70                  75                  80  


Ala Ala Val Pro Arg Leu Arg Pro Pro His Asp Asn Arg Thr Met Val 
                85                  90                  95      


Glu Ile Ile Ala Asp His Pro Ala Glu Leu Val Arg Thr Asp Ser Pro 
            100                 105                 110         


Asn Phe Leu Cys Ser Val Leu Pro Ser His Trp Arg Cys Asn Lys Thr 
        115                 120                 125             


Leu Pro Val Ala Phe Lys Val Val Ala Leu Gly Glu Val Pro Asp Gly 
    130                 135                 140                 


Thr Val Val Thr Val Met Ala Gly Asn Asp Glu Asn Tyr Ser Ala Glu 
145                 150                 155                 160 


Leu Arg Asn Ala Ser Ala Val Met Lys Asn Gln Val Ala Arg Phe Asn 
                165                 170                 175     


Asp Leu Arg Phe Val Gly Arg Ser Gly Arg Asp Pro Arg Gln Ala Gln 
            180                 185                 190         


Ser Ser Pro Pro Trp Ser Tyr Asp Gln Ser Tyr Pro Ser Tyr Leu Ser 
        195                 200                 205             


Gln Met Thr Ser Pro Ser Ile His Ser Thr Thr Pro Leu Ser Ser Thr 
    210                 215                 220                 


Arg Gly Thr Gly Leu Pro Ala Ile Thr Asp Val Pro Arg Arg Ile Ser 
225                 230                 235                 240 


Asp Asp Asp Thr Ala Thr Ser Asp Phe Cys Leu Trp Pro Ser Ser Leu 
                245                 250                 255     


Ser Lys Lys Ser Gln Ala Gly Ala Ser Glu Leu Gly Pro Phe Ser Asp 
            260                 265                 270         


Pro Arg Gln Phe Pro Ser Ile Ser Ser Leu Thr Glu Ser Arg Phe Ser 
        275                 280                 285             


Asn Pro Arg Met His Tyr Pro Ala Thr Phe Thr Tyr Thr Pro Pro Val 
    290                 295                 300                 


Thr Ser Gly Met Ser Leu Gly Met Ser Ala Thr Thr His Tyr His Thr 
305                 310                 315                 320 


Tyr Leu Pro Pro Pro Tyr Pro Gly Ser Ser Gln Ser Gln Ser Gly Pro 
                325                 330                 335     


Phe Gln Thr Ser Ser Thr Pro Tyr Leu Tyr Tyr Gly Thr Ser Ser Ala 
            340                 345                 350         


Ser Tyr Gln Phe Pro Met Val Pro Gly Gly Asp Arg Ser Pro Ser Arg 
        355                 360                 365             


Met Val Pro Pro Cys Thr Thr Thr Ser Asn Gly Ser Thr Leu Leu Asn 
    370                 375                 380                 


Pro Asn Leu Pro Asn Gln Asn Asp Gly Val Asp Ala Asp Gly Ser His 
385                 390                 395                 400 


Ser Ser Ser Pro Thr Val Leu Asn Ser Ser Gly Arg Met Asp Glu Ser 
                405                 410                 415     


Val Trp Arg Pro Tyr 
            420     


<210>  32
<211>  5487
<212>  DNA
<213>  Homo sapiens

<400>  32
gtgtgaatgc ttcattcgcc tcacaaacaa ccacagaacc acaagtgcgg tgcaaacttt       60

ctccaggagg acagcaagaa gtctctggtt tttaaatggt taatctccgc aggtcactac      120

cagccaccga gaccaacaga gtcatttaag gctgcaagca gtatttacaa cagagggtac      180

aagttctatc tgaaaaaaaa aggagggact atggcatcaa acagcctctt cagcacagtg      240

acaccatgtc agcaaaactt cttttgggat ccgagcacca gccggcgctt cagccccccc      300

tccagcagcc tgcagcccgg caaaatgagc gacgtgagcc cggtggtggc tgcgcaacag      360

cagcagcaac agcagcagca gcaacagcag cagcagcagc agcaacagca gcagcagcag      420

caggaggcgg cggcggcggc tgcggcggcg gcggcggctg cggcggcggc agctgcagtg      480

ccccggttgc ggccgcccca cgacaaccgc accatggtgg agatcatcgc cgaccacccg      540

gccgaactcg tccgcaccga cagccccaac ttcctgtgct cggtgctgcc ctcgcactgg      600

cgctgcaaca agaccctgcc cgtggccttc aaggtggtag ccctcggaga ggtaccagat      660

gggactgtgg ttactgtcat ggcgggtaac gatgaaaatt attctgctga gctccggaat      720

gcctctgctg ttatgaaaaa ccaagtagca aggttcaacg atctgagatt tgtgggccgg      780

agtggacgag gcaagagttt caccttgacc ataaccgtct tcacaaatcc tccccaagta      840

gctacctatc acagagcaat taaagttaca gtagatggac ctcgggaacc cagaaggcac      900

agacagaagc ttgatgactc taaacctagt ttgttctctg accgcctcag tgatttaggg      960

cgcattcctc atcccagtat gagagtaggt gtcccgcctc agaacccacg gccctccctg     1020

aactctgcac caagtccttt taatccacaa ggacagagtc agattacaga ccccaggcag     1080

gcacagtctt ccccgccgtg gtcctatgac cagtcttacc cctcctacct gagccagatg     1140

acgtccccgt ccatccactc taccaccccg ctgtcttcca cacggggcac tgggcttcct     1200

gccatcaccg atgtgcctag gcgcatttca ggtgcttcag aactgggccc tttttcagac     1260

cccaggcagt tcccaagcat ttcatccctc actgagagcc gcttctccaa cccacgaatg     1320

cactatccag ccacctttac ttacaccccg ccagtcacct caggcatgtc cctcggtatg     1380

tccgccacca ctcactacca cacctacctg ccaccaccct accccggctc ttcccaaagc     1440

cagagtggac ccttccagac cagcagcact ccatatctct actatggcac ttcgtcagga     1500

tcctatcagt ttcccatggt gccgggggga gaccggtctc cttccagaat gcttccgcca     1560

tgcaccacca cctcgaatgg cagcacgcta ttaaatccaa atttgcctaa ccagaatgat     1620

ggtgttgacg ctgatggaag ccacagcagt tccccaactg ttttgaattc tagtggcaga     1680

atggatgaat ctgtttggcg accatattga aattcctcag cagtggccca gtggtatctg     1740

ggggccacat cccacacgta tcaatatata catatataga gagagtgcat atatatgtat     1800

atcgattagc tatctacaaa gtgcctattt tttagaagat ttttcattca ctcactcagt     1860

catgatcttg cagccataag agggtagata ttgagaagca gaaggctcaa gagagacaat     1920

tgcaatcgag cttcagattg tttactattt aagatgtact tttacaaagg aacaaagaag     1980

ggaaaaggta tttttgtttt tgttgtttgg tctgttatca tcaataacct gttcatatgc     2040

caattcagag aggtggactc caggttcagg agggagaaga gcaaagccgc ttcctctctg     2100

tgctttgaaa cttcacaccc tcacggtggc agctgtgtat ggaccagtgc cctccgcaga     2160

cagctcacaa aaccagttga ggtgcactaa agggacatga ggtagaatgg atgcttccat     2220

cacagtacca tcattcagaa taactcttcc aatttctgct ttcagacatg ctgcaggtcc     2280

tcatctgaac tgttgggttc gttttttttt ttttttttcc tgctccaaga aagtgacttc     2340

aaaaataact gatcaggata gattatttta ttttactttt taacactcct tctccccttt     2400

tcccactgaa ccaaaaagaa atcccatccc taaaacctgc cttctccttt tatgcaaaac     2460

tgaaaatggc aatacattat tatagccata atggtataga tagtgattgc gtttggctat     2520

gtgttgtttt cttttttttt aaattatgaa tatgtgtaaa atctgaggta acttgctaac     2580

gtgaatggtc atataacttt aaagatatat ttataattat ttaatgacat ttggaccctt     2640

gaaacatttc ttagtgtatt gatatgttga cttcggtctc taaaagtgct ctttattaaa     2700

taacaaattt cttcagtggt ctagagccat atctgaaata ttgctaagca atttcagttc     2760

atccaggcac aatgtgattt taaaaaatac ttccatctcc aaatatttta gatatagatt     2820

gtttttgtga tgtatgaagg aaatgttatg tttagttctt tcagatcttt gaatgcctct     2880

aacacagctt tgccttctaa agcggtaatt agggatttaa aaaacaacct ttagcccttt     2940

atcagcatga aatgctggag tgatgtggtt ttctaatttc tttggggtaa ttatgactct     3000

tgtcatatta aaaagacaag cacaagtaaa tcattgaact acagaaaaat gttctgtggt     3060

ttcatagtta agcaaaactc taaatcgcca ggcttcatag caaagacata gtcagctaaa     3120

agccgcacat gtggatagag ggttcaatta tgagacacct agtacaggag agcaaaattg     3180

caccagagat tcttaaccaa ccagccttac caaacaacac aacaggggaa ccccaatctg     3240

ccttacccaa ggccccactg gcagctttcc acagaatttg catttagagg agcagaatga     3300

catcactgtc ctttgggagt aggtcctctg aaaaggcagc aggttccagc aggtagctga     3360

gctgagagga catatggccc acggggacct acagacagcc tttgacattt gtatttctta     3420

caatggaggg ccaaggaggg caaggggctg tggagtttgg tgtctactag tgtgtatgaa     3480

tttgagctag agtccttctg tggcatgcac tttgaccact cctggcagtc acatggcaga     3540

tttccaagtg caaatcctta atccaaacaa ggatcatcta atgacaccac caggccaatc     3600

cctgctctcc tccccgaaaa gtcagggtcc cttcattgga atcctccacc cacccaagca     3660

gaatttagca gagatttgcc ttcaaaccct aacggccccc ttgttctctg gtccttctca     3720

aacccacctt tgtaggccac ccagcattgc aggacagcgt gtggggcagc tggacctgtg     3780

cttcctgcct gggagtctcc cttggaattc atcctgactc cttctaataa aaatggatgg     3840

gaaagcaaaa cactttgcct tctaaaggcc gtataccaag tatgcttaga taaataagcc     3900

acttttctat tacttaagta agaaggaagt agtaattgat actatttatt gtttgtgtgt     3960

ggtagcttga agcacaccac tgtccattta tttgtaagtg taaaatatgt gtgtttgttt     4020

cagcagcact taaaaaagcc agtgtctggt tacacatttc aattttaatt aattgacata     4080

aaaatgctac cgccagtgcc agctgcatcc tatttaatta aaaaggtact atatttgtac     4140

attatttttt aatgttaaaa gggctttttt aagtttacag tacacatacc gagtgacttt     4200

agggatgctt ttgtgttgaa atgttactat agtggctgca ggcagcaacc cagaaacact     4260

ttagaagctt tttttccttg ggaaaaattc aagcacttct tccctccacc ctcactccaa     4320

ccaccccaat gggggtaatt cacatttctt agaacaaatt ctgccctttt ttggtctagg     4380

gattaaaatt ttgtttttct ttctttcttt tttttttttt ttcactgaac ccttaatttg     4440

cactgggtca tgtgtttgat ttgtgatttc aagaccaaag caaagtctta ctactactgt     4500

ggaaccatgt actagttcct gggaattaaa atagcgtggt tctctttgta gcacaaacat     4560

tgctggaatt tgcagtcttt tcaatgcagc cacattttta tccatttcag ttgtctcaca     4620

aattttaacc catatcagag ttccagaaca ggtaccacag ctttggtttt agattagtgg     4680

aataacattc agcccagaac tgagaaactc aacagattaa ctatcgtttg ctctttagac     4740

ggtctcactg cctctcactt gccagagccc tttcaaaatg agcagagaag tccacaccat     4800

tagggaccat ctgtgataaa ttcagaaggg aggagatgtg tgtacagctt taaggattcc     4860

ctcaattccg aggaaaggga ctggcccaga atccaggtta atacatggaa acacgaagca     4920

ttagcaaaag taataattat acctatggta tttgaaagaa caataataaa agacacttct     4980

tccaaacctt gaatttgttg tttttagaaa acgaatgcat ttaaaaatat tttctatgtg     5040

agaatttttt agatgtgtgt ttacttcatg tttacaaata actgtttgct ttttaatgca     5100

gtactttgaa atatatcagc caaaaccata acttacaata atttcttagg tattctgaat     5160

aaaattccat ttcttttgga tatgctttac cattcttagg tttctgtgga acaaaaatat     5220

ttgtagcatt ttgtgtaaat acaagctttc atttttattt tttccaattg ctattgccca     5280

agaattgctt tccatgcaca tattgtaaaa attccgcttt gtgccacagg tcatgattgt     5340

ggatgagttt actcttaact tcaaagggac tatttgtatt gtatgttgca actgtaaatt     5400

gaattatttg gcatttttct catgattgta atattaattt gaagtttgaa tttaattttc     5460

aataaaatgg cttttttggt tttgtta                                         5487


<210>  33
<211>  5553
<212>  DNA
<213>  Homo sapiens

<400>  33
gtgtgaatgc ttcattcgcc tcacaaacaa ccacagaacc acaagtgcgg tgcaaacttt       60

ctccaggagg acagcaagaa gtctctggtt tttaaatggt taatctccgc aggtcactac      120

cagccaccga gaccaacaga gtcatttaag gctgcaagca gtatttacaa cagagggtac      180

aagttctatc tgaaaaaaaa aggagggact atggcatcaa acagcctctt cagcacagtg      240

acaccatgtc agcaaaactt cttttgggat ccgagcacca gccggcgctt cagccccccc      300

tccagcagcc tgcagcccgg caaaatgagc gacgtgagcc cggtggtggc tgcgcaacag      360

cagcagcaac agcagcagca gcaacagcag cagcagcagc agcaacagca gcagcagcag      420

caggaggcgg cggcggcggc tgcggcggcg gcggcggctg cggcggcggc agctgcagtg      480

ccccggttgc ggccgcccca cgacaaccgc accatggtgg agatcatcgc cgaccacccg      540

gccgaactcg tccgcaccga cagccccaac ttcctgtgct cggtgctgcc ctcgcactgg      600

cgctgcaaca agaccctgcc cgtggccttc aaggtggtag ccctcggaga ggtaccagat      660

gggactgtgg ttactgtcat ggcgggtaac gatgaaaatt attctgctga gctccggaat      720

gcctctgctg ttatgaaaaa ccaagtagca aggttcaacg atctgagatt tgtgggccgg      780

agtggacgag gcaagagttt caccttgacc ataaccgtct tcacaaatcc tccccaagta      840

gctacctatc acagagcaat taaagttaca gtagatggac ctcgggaacc cagaaggcac      900

agacagaagc ttgatgactc taaacctagt ttgttctctg accgcctcag tgatttaggg      960

cgcattcctc atcccagtat gagagtaggt gtcccgcctc agaacccacg gccctccctg     1020

aactctgcac caagtccttt taatccacaa ggacagagtc agattacaga ccccaggcag     1080

gcacagtctt ccccgccgtg gtcctatgac cagtcttacc cctcctacct gagccagatg     1140

acgtccccgt ccatccactc taccaccccg ctgtcttcca cacggggcac tgggcttcct     1200

gccatcaccg atgtgcctag gcgcatttca gatgatgaca ctgccacctc tgacttctgc     1260

ctctggcctt ccactctcag taagaagagc caggcaggtg cttcagaact gggccctttt     1320

tcagacccca ggcagttccc aagcatttca tccctcactg agagccgctt ctccaaccca     1380

cgaatgcact atccagccac ctttacttac accccgccag tcacctcagg catgtccctc     1440

ggtatgtccg ccaccactca ctaccacacc tacctgccac caccctaccc cggctcttcc     1500

caaagccaga gtggaccctt ccagaccagc agcactccat atctctacta tggcacttcg     1560

tcaggatcct atcagtttcc catggtgccg gggggagacc ggtctccttc cagaatgctt     1620

ccgccatgca ccaccacctc gaatggcagc acgctattaa atccaaattt gcctaaccag     1680

aatgatggtg ttgacgctga tggaagccac agcagttccc caactgtttt gaattctagt     1740

ggcagaatgg atgaatctgt ttggcgacca tattgaaatt cctcagcagt ggcccagtgg     1800

tatctggggg ccacatccca cacgtatcaa tatatacata tatagagaga gtgcatatat     1860

atgtatatcg attagctatc tacaaagtgc ctatttttta gaagattttt cattcactca     1920

ctcagtcatg atcttgcagc cataagaggg tagatattga gaagcagaag gctcaagaga     1980

gacaattgca atcgagcttc agattgttta ctatttaaga tgtactttta caaaggaaca     2040

aagaagggaa aaggtatttt tgtttttgtt gtttggtctg ttatcatcaa taacctgttc     2100

atatgccaat tcagagaggt ggactccagg ttcaggaggg agaagagcaa agccgcttcc     2160

tctctgtgct ttgaaacttc acaccctcac ggtggcagct gtgtatggac cagtgccctc     2220

cgcagacagc tcacaaaacc agttgaggtg cactaaaggg acatgaggta gaatggatgc     2280

ttccatcaca gtaccatcat tcagaataac tcttccaatt tctgctttca gacatgctgc     2340

aggtcctcat ctgaactgtt gggttcgttt tttttttttt ttttcctgct ccaagaaagt     2400

gacttcaaaa ataactgatc aggatagatt attttatttt actttttaac actccttctc     2460

cccttttccc actgaaccaa aaagaaatcc catccctaaa acctgccttc tccttttatg     2520

caaaactgaa aatggcaata cattattata gccataatgg tatagatagt gattgcgttt     2580

ggctatgtgt tgttttcttt ttttttaaat tatgaatatg tgtaaaatct gaggtaactt     2640

gctaacgtga atggtcatat aactttaaag atatatttat aattatttaa tgacatttgg     2700

acccttgaaa catttcttag tgtattgata tgttgacttc ggtctctaaa agtgctcttt     2760

attaaataac aaatttcttc agtggtctag agccatatct gaaatattgc taagcaattt     2820

cagttcatcc aggcacaatg tgattttaaa aaatacttcc atctccaaat attttagata     2880

tagattgttt ttgtgatgta tgaaggaaat gttatgttta gttctttcag atctttgaat     2940

gcctctaaca cagctttgcc ttctaaagcg gtaattaggg atttaaaaaa caacctttag     3000

ccctttatca gcatgaaatg ctggagtgat gtggttttct aatttctttg gggtaattat     3060

gactcttgtc atattaaaaa gacaagcaca agtaaatcat tgaactacag aaaaatgttc     3120

tgtggtttca tagttaagca aaactctaaa tcgccaggct tcatagcaaa gacatagtca     3180

gctaaaagcc gcacatgtgg atagagggtt caattatgag acacctagta caggagagca     3240

aaattgcacc agagattctt aaccaaccag ccttaccaaa caacacaaca ggggaacccc     3300

aatctgcctt acccaaggcc ccactggcag ctttccacag aatttgcatt tagaggagca     3360

gaatgacatc actgtccttt gggagtaggt cctctgaaaa ggcagcaggt tccagcaggt     3420

agctgagctg agaggacata tggcccacgg ggacctacag acagcctttg acatttgtat     3480

ttcttacaat ggagggccaa ggagggcaag gggctgtgga gtttggtgtc tactagtgtg     3540

tatgaatttg agctagagtc cttctgtggc atgcactttg accactcctg gcagtcacat     3600

ggcagatttc caagtgcaaa tccttaatcc aaacaaggat catctaatga caccaccagg     3660

ccaatccctg ctctcctccc cgaaaagtca gggtcccttc attggaatcc tccacccacc     3720

caagcagaat ttagcagaga tttgccttca aaccctaacg gcccccttgt tctctggtcc     3780

ttctcaaacc cacctttgta ggccacccag cattgcagga cagcgtgtgg ggcagctgga     3840

cctgtgcttc ctgcctggga gtctcccttg gaattcatcc tgactccttc taataaaaat     3900

ggatgggaaa gcaaaacact ttgccttcta aaggccgtat accaagtatg cttagataaa     3960

taagccactt ttctattact taagtaagaa ggaagtagta attgatacta tttattgttt     4020

gtgtgtggta gcttgaagca caccactgtc catttatttg taagtgtaaa atatgtgtgt     4080

ttgtttcagc agcacttaaa aaagccagtg tctggttaca catttcaatt ttaattaatt     4140

gacataaaaa tgctaccgcc agtgccagct gcatcctatt taattaaaaa ggtactatat     4200

ttgtacatta ttttttaatg ttaaaagggc ttttttaagt ttacagtaca cataccgagt     4260

gactttaggg atgcttttgt gttgaaatgt tactatagtg gctgcaggca gcaacccaga     4320

aacactttag aagctttttt tccttgggaa aaattcaagc acttcttccc tccaccctca     4380

ctccaaccac cccaatgggg gtaattcaca tttcttagaa caaattctgc ccttttttgg     4440

tctagggatt aaaattttgt ttttctttct ttcttttttt ttttttttca ctgaaccctt     4500

aatttgcact gggtcatgtg tttgatttgt gatttcaaga ccaaagcaaa gtcttactac     4560

tactgtggaa ccatgtacta gttcctggga attaaaatag cgtggttctc tttgtagcac     4620

aaacattgct ggaatttgca gtcttttcaa tgcagccaca tttttatcca tttcagttgt     4680

ctcacaaatt ttaacccata tcagagttcc agaacaggta ccacagcttt ggttttagat     4740

tagtggaata acattcagcc cagaactgag aaactcaaca gattaactat cgtttgctct     4800

ttagacggtc tcactgcctc tcacttgcca gagccctttc aaaatgagca gagaagtcca     4860

caccattagg gaccatctgt gataaattca gaagggagga gatgtgtgta cagctttaag     4920

gattccctca attccgagga aagggactgg cccagaatcc aggttaatac atggaaacac     4980

gaagcattag caaaagtaat aattatacct atggtatttg aaagaacaat aataaaagac     5040

acttcttcca aaccttgaat ttgttgtttt tagaaaacga atgcatttaa aaatattttc     5100

tatgtgagaa ttttttagat gtgtgtttac ttcatgttta caaataactg tttgcttttt     5160

aatgcagtac tttgaaatat atcagccaaa accataactt acaataattt cttaggtatt     5220

ctgaataaaa ttccatttct tttggatatg ctttaccatt cttaggtttc tgtggaacaa     5280

aaatatttgt agcattttgt gtaaatacaa gctttcattt ttattttttc caattgctat     5340

tgcccaagaa ttgctttcca tgcacatatt gtaaaaattc cgctttgtgc cacaggtcat     5400

gattgtggat gagtttactc ttaacttcaa agggactatt tgtattgtat gttgcaactg     5460

taaattgaat tatttggcat ttttctcatg attgtaatat taatttgaag tttgaattta     5520

attttcaata aaatggcttt tttggttttg tta                                  5553


<210>  34
<211>  5235
<212>  DNA
<213>  Homo sapiens

<400>  34
atgcgtattc ccgtagatcc gagcaccagc cggcgcttca gccccccctc cagcagcctg       60

cagcccggca aaatgagcga cgtgagcccg gtggtggctg cgcaacagca gcagcaacag      120

cagcagcagc aacagcagca gcagcagcag caacagcagc agcagcagca ggaggcggcg      180

gcggcggctg cggcggcggc ggcggctgcg gcggcggcag ctgcagtgcc ccggttgcgg      240

ccgccccacg acaaccgcac catggtggag atcatcgccg accacccggc cgaactcgtc      300

cgcaccgaca gccccaactt cctgtgctcg gtgctgccct cgcactggcg ctgcaacaag      360

accctgcccg tggccttcaa ggtggtagcc ctcggagagg taccagatgg gactgtggtt      420

actgtcatgg cgggtaacga tgaaaattat tctgctgagc tccggaatgc ctctgctgtt      480

atgaaaaacc aagtagcaag gttcaacgat ctgagatttg tgggccggag tggacgaggc      540

aagagtttca ccttgaccat aaccgtcttc acaaatcctc cccaagtagc tacctatcac      600

agagcaatta aagttacagt agatggacct cgggaaccca gaaggcacag acagaagctt      660

gatgactcta aacctagttt gttctctgac cgcctcagtg atttagggcg cattcctcat      720

cccagtatga gagtaggtgt cccgcctcag aacccacggc cctccctgaa ctctgcacca      780

agtcctttta atccacaagg acagagtcag attacagacc ccaggcaggc acagtcttcc      840

ccgccgtggt cctatgacca gtcttacccc tcctacctga gccagatgac gtccccgtcc      900

atccactcta ccaccccgct gtcttccaca cggggcactg ggcttcctgc catcaccgat      960

gtgcctaggc gcatttcagg tgcttcagaa ctgggccctt tttcagaccc caggcagttc     1020

ccaagcattt catccctcac tgagagccgc ttctccaacc cacgaatgca ctatccagcc     1080

acctttactt acaccccgcc agtcacctca ggcatgtccc tcggtatgtc cgccaccact     1140

cactaccaca cctacctgcc accaccctac cccggctctt cccaaagcca gagtggaccc     1200

ttccagacca gcagcactcc atatctctac tatggcactt cgtcaggatc ctatcagttt     1260

cccatggtgc cggggggaga ccggtctcct tccagaatgc ttccgccatg caccaccacc     1320

tcgaatggca gcacgctatt aaatccaaat ttgcctaacc agaatgatgg tgttgacgct     1380

gatggaagcc acagcagttc cccaactgtt ttgaattcta gtggcagaat ggatgaatct     1440

gtttggcgac catattgaaa ttcctcagca gtggcccagt ggtatctggg ggccacatcc     1500

cacacgtatc aatatataca tatatagaga gagtgcatat atatgtatat cgattagcta     1560

tctacaaagt gcctattttt tagaagattt ttcattcact cactcagtca tgatcttgca     1620

gccataagag ggtagatatt gagaagcaga aggctcaaga gagacaattg caatcgagct     1680

tcagattgtt tactatttaa gatgtacttt tacaaaggaa caaagaaggg aaaaggtatt     1740

tttgtttttg ttgtttggtc tgttatcatc aataacctgt tcatatgcca attcagagag     1800

gtggactcca ggttcaggag ggagaagagc aaagccgctt cctctctgtg ctttgaaact     1860

tcacaccctc acggtggcag ctgtgtatgg accagtgccc tccgcagaca gctcacaaaa     1920

ccagttgagg tgcactaaag ggacatgagg tagaatggat gcttccatca cagtaccatc     1980

attcagaata actcttccaa tttctgcttt cagacatgct gcaggtcctc atctgaactg     2040

ttgggttcgt tttttttttt ttttttcctg ctccaagaaa gtgacttcaa aaataactga     2100

tcaggataga ttattttatt ttacttttta acactccttc tccccttttc ccactgaacc     2160

aaaaagaaat cccatcccta aaacctgcct tctcctttta tgcaaaactg aaaatggcaa     2220

tacattatta tagccataat ggtatagata gtgattgcgt ttggctatgt gttgttttct     2280

ttttttttaa attatgaata tgtgtaaaat ctgaggtaac ttgctaacgt gaatggtcat     2340

ataactttaa agatatattt ataattattt aatgacattt ggacccttga aacatttctt     2400

agtgtattga tatgttgact tcggtctcta aaagtgctct ttattaaata acaaatttct     2460

tcagtggtct agagccatat ctgaaatatt gctaagcaat ttcagttcat ccaggcacaa     2520

tgtgatttta aaaaatactt ccatctccaa atattttaga tatagattgt ttttgtgatg     2580

tatgaaggaa atgttatgtt tagttctttc agatctttga atgcctctaa cacagctttg     2640

ccttctaaag cggtaattag ggatttaaaa aacaaccttt agccctttat cagcatgaaa     2700

tgctggagtg atgtggtttt ctaatttctt tggggtaatt atgactcttg tcatattaaa     2760

aagacaagca caagtaaatc attgaactac agaaaaatgt tctgtggttt catagttaag     2820

caaaactcta aatcgccagg cttcatagca aagacatagt cagctaaaag ccgcacatgt     2880

ggatagaggg ttcaattatg agacacctag tacaggagag caaaattgca ccagagattc     2940

ttaaccaacc agccttacca aacaacacaa caggggaacc ccaatctgcc ttacccaagg     3000

ccccactggc agctttccac agaatttgca tttagaggag cagaatgaca tcactgtcct     3060

ttgggagtag gtcctctgaa aaggcagcag gttccagcag gtagctgagc tgagaggaca     3120

tatggcccac ggggacctac agacagcctt tgacatttgt atttcttaca atggagggcc     3180

aaggagggca aggggctgtg gagtttggtg tctactagtg tgtatgaatt tgagctagag     3240

tccttctgtg gcatgcactt tgaccactcc tggcagtcac atggcagatt tccaagtgca     3300

aatccttaat ccaaacaagg atcatctaat gacaccacca ggccaatccc tgctctcctc     3360

cccgaaaagt cagggtccct tcattggaat cctccaccca cccaagcaga atttagcaga     3420

gatttgcctt caaaccctaa cggccccctt gttctctggt ccttctcaaa cccacctttg     3480

taggccaccc agcattgcag gacagcgtgt ggggcagctg gacctgtgct tcctgcctgg     3540

gagtctccct tggaattcat cctgactcct tctaataaaa atggatggga aagcaaaaca     3600

ctttgccttc taaaggccgt ataccaagta tgcttagata aataagccac ttttctatta     3660

cttaagtaag aaggaagtag taattgatac tatttattgt ttgtgtgtgg tagcttgaag     3720

cacaccactg tccatttatt tgtaagtgta aaatatgtgt gtttgtttca gcagcactta     3780

aaaaagccag tgtctggtta cacatttcaa ttttaattaa ttgacataaa aatgctaccg     3840

ccagtgccag ctgcatccta tttaattaaa aaggtactat atttgtacat tattttttaa     3900

tgttaaaagg gcttttttaa gtttacagta cacataccga gtgactttag ggatgctttt     3960

gtgttgaaat gttactatag tggctgcagg cagcaaccca gaaacacttt agaagctttt     4020

tttccttggg aaaaattcaa gcacttcttc cctccaccct cactccaacc accccaatgg     4080

gggtaattca catttcttag aacaaattct gccctttttt ggtctaggga ttaaaatttt     4140

gtttttcttt ctttcttttt tttttttttt cactgaaccc ttaatttgca ctgggtcatg     4200

tgtttgattt gtgatttcaa gaccaaagca aagtcttact actactgtgg aaccatgtac     4260

tagttcctgg gaattaaaat agcgtggttc tctttgtagc acaaacattg ctggaatttg     4320

cagtcttttc aatgcagcca catttttatc catttcagtt gtctcacaaa ttttaaccca     4380

tatcagagtt ccagaacagg taccacagct ttggttttag attagtggaa taacattcag     4440

cccagaactg agaaactcaa cagattaact atcgtttgct ctttagacgg tctcactgcc     4500

tctcacttgc cagagccctt tcaaaatgag cagagaagtc cacaccatta gggaccatct     4560

gtgataaatt cagaagggag gagatgtgtg tacagcttta aggattccct caattccgag     4620

gaaagggact ggcccagaat ccaggttaat acatggaaac acgaagcatt agcaaaagta     4680

ataattatac ctatggtatt tgaaagaaca ataataaaag acacttcttc caaaccttga     4740

atttgttgtt tttagaaaac gaatgcattt aaaaatattt tctatgtgag aattttttag     4800

atgtgtgttt acttcatgtt tacaaataac tgtttgcttt ttaatgcagt actttgaaat     4860

atatcagcca aaaccataac ttacaataat ttcttaggta ttctgaataa aattccattt     4920

cttttggata tgctttacca ttcttaggtt tctgtggaac aaaaatattt gtagcatttt     4980

gtgtaaatac aagctttcat ttttattttt tccaattgct attgcccaag aattgctttc     5040

catgcacata ttgtaaaaat tccgctttgt gccacaggtc atgattgtgg atgagtttac     5100

tcttaacttc aaagggacta tttgtattgt atgttgcaac tgtaaattga attatttggc     5160

atttttctca tgattgtaat attaatttga agtttgaatt taattttcaa taaaatggct     5220

tttttggttt tgtta                                                      5235


<210>  35
<211>  6475
<212>  DNA
<213>  Mus musculus

<400>  35
ctgaagttaa caacgaaaaa ttaacgccag tcggagcagc ctgaggctct cccgcttctc       60

agctttagcg tcgtcagacc gagaagtggt tcccggtcct gagggtgaag tggggagccg      120

aggacgcagg cggcgatgtc ctaggcgggg acctcctccc tacagcttcg ggcgccgagc      180

gagcgcagcg gcgcttctag cggccggcgg gcggcggcag cggctgcgat ccgcaggctc      240

cagatctgtc gccccgagat ccgctctccc cccgccccca cttacctccc ggcaccttga      300

aacgcgaggg gggcccgggg cactttgcaa agagcaggag agacgaggct gcgagctaga      360

cggcggcgaa ggagagggcg agaggagaag ccggggaaag gaaggactcg gcggccggag      420

gactcggagc gcgctgccgg cgcggggagc gcgcagcggc ctcggaggag gaggcggagg      480

aggcggcgcg ggcaagcgac ggcgccgcga gctgggcagc cgcgctctgc ttggcggtgg      540

cggacagcga ggagccacac gcaccgccga gatggactgc tgaacctgcg gggctccact      600

accgtactgg aacccggagc ggggcgccag cgcacccagg acacggtgcc ccaaggggcc      660

cctactgcaa gctgttaact tcaagtccct tgcggcggct gggccaaaca cgcccccgcg      720

tcccgctcgt tgcagccacc gccagggact cccaagcctc ccggtggaga tccgcgcctc      780

tcgggtgtcc ccacccgcta ccccgactct gtccggtctc cagtcgccgg cccccagcag      840

actccgcccg gcacacggct tcctcgaact tgatttctca cctcctctgt cccgtcacct      900

ccatcctctt tccgcccccg tctcgcctcc accccctcga tttcctcctc ctcgcccccc      960

atttccaccc tcctccccct cccccggcca cttcgctaac ttgtggctgt tgtgatgcgt     1020

attcctgtag atccgagcac cagccggcgc ttcagccccc cctccagcag cctgcagccc     1080

ggcaagatga gcgacgtgag cccggtggtg gctgcgcagc agcagcaaca gcagcagcag     1140

cagcagcaac agcagcagca acaacagcaa cagcaacaac agcagcagca gcagcagcag     1200

caggaggcgg ccgcagcagc agcggcggca gcggcggcgg cagcagcggc ggcggccgca     1260

gtgccccgat tgaggccgcc gcacgacaac cgcaccatgg tggagatcat cgcggaccac     1320

ccggccgaac tggtccgcac cgacagtccc aacttcctgt gctccgtgct gccctcgcac     1380

tggcggtgca acaagaccct gcccgtggcc ttcaaggttg tagccctcgg agaggtacca     1440

gatgggactg tggttaccgt catggccggg aatgatgaga actactccgc cgagctccga     1500

aatgcctccg ctgttatgaa aaaccaagta gccaggttca acgatctgag atttgtgggc     1560

cggagcggac gaggcaagag tttcaccttg accataacag tcttcacaaa tcctccccaa     1620

gtggccactt accacagagc tattaaagtg acagtggacg gtccccggga accaagaagg     1680

cacagacaga agcttgatga ctctaaacct agtttgttct ctgatcgcct cagtgattta     1740

gggcgcattc ctcatcccag tatgagagta ggtgtcccgc ctcagaaccc acggccctcc     1800

ctgaactctg caccaagtcc ttttaatcca caaggacaga gtcagattac agatcccagg     1860

caggcacagt cttccccacc gtggtcctat gaccagtctt acccctccta tctgagccag     1920

atgacatccc catccatcca ctccaccacg ccgctgtctt ccacacgggg caccgggcta     1980

cctgccatca ctgacgtgcc caggcgtatt tcagatgatg acactgccac ctctgacttc     2040

tgcctctggc cttcctctct cagtaagaag agccaggcag gtgcttcaga actgggccct     2100

ttttcagacc ccaggcagtt cccaagcatt tcatccctca ctgagagccg cttctccaac     2160

ccacgaatgc actacccagc cacctttacc tacaccccgc cagtcacgtc aggcatgtcc     2220

ctcggcatgt ccgccaccac tcactaccac acgtacctgc caccacccta ccccggctct     2280

tcccaaagcc agagtggacc cttccagacc agcagcactc catatctcta ctatggtact     2340

tcgtcagcat cctatcagtt cccaatggta cccgggggag accggtctcc ttccaggatg     2400

gtcccaccat gcaccaccac ctcgaatggc agcacgctat taaatccaaa tttgcctaac     2460

cagaatgatg gtgttgacgc tgacggaagc cacagcagtt ccccaactgt tttgaattct     2520

agcggcagaa tggatgagtc tgtttggcgg ccatattgaa attcgtcaac catggcccag     2580

tggcatgggg gccacatccc gcatgtgtta atatatacat atataaagag agtgcctata     2640

tatgtatatt gattagctaa ctagaagatt tctcattcaa tccctagtca tgatcttgca     2700

accctaagag ggtgggggca gtcataactg ggtttcatat tgtttactat ttaagatgtc     2760

ccctttacca aggaacaaac cgtcaaaggt gttgtctggt ctgttttcat aagtgacctg     2820

ttcccacgcc ggttcagaga ggtggactct gggtctggga ggaaggagag acacttcctc     2880

tctgtgcttt gaaaccacag cctctgctgt gtggcagccg gtacactctg cagacccgct     2940

tacagagtca gatgtggtgc actcagaaag ggacaagagg cagagtggct gcttctgtcc     3000

gctgccgtcc actctgccgt ccacctgttc caaagttttc cttcagactt gctgcaggta     3060

ctcatttgaa cttttgagtt cacttttttt ttttcctatt ctaagaaagt gacttcaaaa     3120

atactgatca ggacagataa ttttatttta ccttttatat tttctcactt cccccattta     3180

accaaaaaga aatcccgttc cccctccccc gttccttctg cttctccctt tatgcaaact     3240

gaaaatggca atgccttatt attatagcca taatggtata gtgtttgagt tggctgtgtg     3300

ttatgtgttt ttttcttttt ttttcttttt taaattatga atatgtgtaa aatctgaagt     3360

aacttgctaa cgtgaatggt catataactt taaagatata tttataatta tttaatgaca     3420

tttggacatt tggaacattt cttagtgtaa tgatatgttg acttcggtct ctaaaagtgt     3480

gcttcttctt caataccaag tttcttcagt gggctagagc catatcggaa atattgctaa     3540

gcaatctcaa ttccttcagg cataatgtga tttttttttt tttttgaaga taactcccat     3600

ctccaaatag tttagatgta gtttgttttc acgatgtatg aaggagatgc tctgtttctt     3660

tctttcaggc atttgattgc ctctgacaca gctttgcctt ttaaagcaat aattagggat     3720

taaaataaca aaaacaaaac aaaagccacc tatagccctt taacacttaa cgtggcccct     3780

ttactagcat gaaatgctgg agacatgtgg tttcctaatt tctccatttt gggggtggtg     3840

ggagggggga gggtggccat tatgactctt atcatattaa aaagccaagc acaagtgatt     3900

ggttgaactg cagaaaagtg ttctgtggtc tctgagttga gcaaaactct aaattgcagg     3960

cttcgtggtt gagggcctag tcagctgaaa gccacgcgtg tggtaaaggc tcaggcatgg     4020

cttggagaac ctaggaacac attaggagcc tgcacctacc agcctcacca tacagccatt     4080

caggggaacc caaaaagtgc cttacccaag gagggccccc agcagctttc caggaagtcg     4140

aatgaagtcg ctgtcctcgg ggaactggtc agctgaagta gcaaccggta gctgatgtca     4200

gtagacaaca gaacctgtgg ggacctccag gaaacctttg acattggagg ctttcattag     4260

gcagggccaa caagagcagg gaaggccatg tacccattgg tatctgccat tgtgtgtgag     4320

tttgagatcc agccctcctt ggaggatgta ctgtgatcat tcctggtacc ttagggccaa     4380

tccctaagtg tggcttccta atccaggcca gggatcattc agtgatacca ccaggccaat     4440

cccagcattc ctcctgcaca aagtgtttgt gtgtgggggg atagattggg gtggggccac     4500

cttcatttga atcctgagtc attctaagag ttctgcaagc ttttgccttc agcaccctat     4560

accccctcgc tctctgttcc ttctcaggtt gacctttgtc ccaatgcggg acagtccaga     4620

ggcagatggg gacctatgtg tgcctccaac ctgcgttttc ctcagaattc atcctgactc     4680

cctctgacac agattgaggg gggggggaag aaacccaacc cgcaccaaag caaaacactt     4740

tgccttctaa aggctgtgca ccaagtagac gcagatggtc agcccacctt tgtgtttcct     4800

taagatggaa attgtaactg atgctattta ttgtttgtgt gtggtagctt gaagcacacc     4860

acggtccatg tgtttgtctg atacctattt cagcagcatt tacaaaagcc agtgtctggt     4920

tacacttttc agttttcatt aatcaacatg aaaatgttac cattggtgcc agctgcaccc     4980

tatttaattt ttttaagggc actatatttg tacatttcgt ttttaatgtt aaagggcttc     5040

ttaaagttta cagtacagtt atcaagggaa tagaggggat gcattagtgc ctaaatgtta     5100

ttctagtggc tgcaggcagc aacccagaag cagttttgaa aacaggttgt ttccctctgt     5160

cctcccttat ttgggaaaat tcaagtgctt tcttcacctt tcaggcacct cacggtgact     5220

cccgttactt agagcagtct gtcgtcgtct tcttcttctt cctcttcctc ttcctcttcc     5280

tcttcctctt cctcttcctc ttcctcttcc tcttcctctt cttcttcttc ttcttcttct     5340

tcttcttctt cttcttcctc ctagggttta aaatccccct tcctcttccc ttatctctta     5400

aactcttcat ttgcactggg tcacacgtat gatttgtggt tttaagacca aagcaatgtc     5460

ttattactct tctggagccg tttatgtgta ctaaccaacc cttccctcca cttccctggg     5520

tttagatgca cacggttctc aaaggagcac aaacatggcc agattcacag tgggacccac     5580

acagccatgt taaaaaaaaa aacaaaaaaa aacctcttca cttgtctgag aattttaacc     5640

tgggccccaa ttgctaacgg gcaccatggc ttgggtttca ggttagggaa cgttgcccag     5700

tgagtaacag aaagacttaa ctgatttaat tagtttgccc tcatccttca ctccaagacc     5760

ctaagaaacc gatcagagaa acatctccac accattagag gttgagaagg gaggagccat     5820

gtgggggttc cctccgctcg gaggaaaggc actgactgac ctagttagag tggtagcaga     5880

agcacccatg gtatctgaga gagcaataaa caataaaaga tgatcctccc aagcttagaa     5940

tttgttgttc ttaaagaaga cgatgcatct aaaacaaaga attttttttt ctatgtggga     6000

actttcttcg ttgtctgttt acttcatgtt tacaaataat tgtttgcttt ttaatgcagt     6060

actttaaaaa atatatcagc caaaaccata acttacagta atttttttag gtattctgaa     6120

taaaattcca tgtcttttga tatgtctact gttcttaggt ttctgtggaa caacaacaac     6180

aacaacaaca aaattgtagc attttgtgta aatacagctt tcgttcttat tttttatttt     6240

tctgattgct attgcccaag atttgctttc tatgcacgta ttgtacaaat tgtgctttgt     6300

gccacaggtc atgatcgtgg atgagtttac tctgaacttc aaagggacta tttgtattgt     6360

atgttgcaac tgtaaattga attatttggc atttccccct ctcatgattg taatattaat     6420

ttgaagtttg aatttaattt tcaataaaaa ggcttttttt ttccttttgg ttttg          6475


<210>  36
<211>  5740
<212>  DNA
<213>  Mus musculus

<400>  36
atgcttcatt cgcctcacaa acaaccacag aaccacaagt gcggtgcaaa ctttctccag       60

gaagactgca agaaggctct ggcgtttaaa tggttaatct ctgcaggtca ctaccagcca      120

ccgagaccaa ccgagtcagt gagtgctcta accacagtcc atgcaggaat atttaaggct      180

gcaagcagta tttacaacag agggcacaag ttctatctgg aaaaaaaagg agggactatg      240

gcgtcaaaca gcctcttcag cgcagtgaca ccgtgtcagc aaagcttctt ttgggatccg      300

agcaccagcc ggcgcttcag ccccccctcc agcagcctgc agcccggcaa gatgagcgac      360

gtgagcccgg tggtggctgc gcagcagcag caacagcagc agcagcagca gcaacagcag      420

cagcaacaac agcaacagca acaacagcag cagcagcagc agcagcagga ggcggccgca      480

gcagcagcgg cggcagcggc ggcggcagca gcggcggcgg ccgcagtgcc ccgattgagg      540

ccgccgcacg acaaccgcac catggtggag atcatcgcgg accacccggc cgaactggtc      600

cgcaccgaca gtcccaactt cctgtgctcc gtgctgccct cgcactggcg gtgcaacaag      660

accctgcccg tggccttcaa ggttgtagcc ctcggagagg taccagatgg gactgtggtt      720

accgtcatgg ccgggaatga tgagaactac tccgccgagc tccgaaatgc ctccgctgtt      780

atgaaaaacc aagtagccag gttcaacgat ctgagatttg tgggccggag cggacgaggc      840

aagagtttca ccttgaccat aacagtcttc acaaatcctc cccaagtggc cacttaccac      900

agagctatta aagtgacagt ggacggtccc cgggaaccaa gaaggcacag acagaagctt      960

gatgactcta aacctagttt gttctctgat cgcctcagtg atttagggcg cattcctcat     1020

cccagtatga gagtaggtgt cccgcctcag aacccacggc cctccctgaa ctctgcacca     1080

agtcctttta atccacaagg acagagtcag attacagatc ccaggcaggc acagtcttcc     1140

ccaccgtggt cctatgacca gtcttacccc tcctatctga gccagatgac atccccatcc     1200

atccactcca ccacgccgct gtcttccaca cggggcaccg ggctacctgc catcactgac     1260

gtgcccaggc gtatttcaga tgatgacact gccacctctg acttctgcct ctggccttcc     1320

tctctcagta agaagagcca ggcaggtgct tcagaactgg gccctttttc agaccccagg     1380

cagttcccaa gcatttcatc cctcactgag agccgcttct ccaacccacg aatgcactac     1440

ccagccacct ttacctacac cccgccagtc acgtcaggca tgtccctcgg catgtccgcc     1500

accactcact accacacgta cctgccacca ccctaccccg gctcttccca aagccagagt     1560

ggacccttcc agaccagcag cactccatat ctctactatg gtacttcgtc agcatcctat     1620

cagttcccaa tggtacccgg gggagaccgg tctccttcca ggatggtccc accatgcacc     1680

accacctcga atggcagcac gctattaaat ccaaatttgc ctaaccagaa tgatggtgtt     1740

gacgctgacg gaagccacag cagttcccca actgttttga attctagcgg cagaatggat     1800

gagtctgttt ggcggccata ttgaaattcg tcaaccatgg cccagtggca tgggggccac     1860

atcccgcatg tgttaatata tacatatata aagagagtgc ctatatatgt atattgatta     1920

gctaactaga agatttctca ttcaatccct agtcatgatc ttgcaaccct aagagggtgg     1980

gggcagtcat aactgggttt catattgttt actatttaag atgtcccctt taccaaggaa     2040

caaaccgtca aaggtgttgt ctggtctgtt ttcataagtg acctgttccc acgccggttc     2100

agagaggtgg actctgggtc tgggaggaag gagagacact tcctctctgt gctttgaaac     2160

cacagcctct gctgtgtggc agccggtaca ctctgcagac ccgcttacag agtcagatgt     2220

ggtgcactca gaaagggaca agaggcagag tggctgcttc tgtccgctgc cgtccactct     2280

gccgtccacc tgttccaaag ttttccttca gacttgctgc aggtactcat ttgaactttt     2340

gagttcactt tttttttttc ctattctaag aaagtgactt caaaaatact gatcaggaca     2400

gataatttta ttttaccttt tatattttct cacttccccc atttaaccaa aaagaaatcc     2460

cgttccccct cccccgttcc ttctgcttct ccctttatgc aaactgaaaa tggcaatgcc     2520

ttattattat agccataatg gtatagtgtt tgagttggct gtgtgttatg tgtttttttc     2580

tttttttttc ttttttaaat tatgaatatg tgtaaaatct gaagtaactt gctaacgtga     2640

atggtcatat aactttaaag atatatttat aattatttaa tgacatttgg acatttggaa     2700

catttcttag tgtaatgata tgttgacttc ggtctctaaa agtgtgcttc ttcttcaata     2760

ccaagtttct tcagtgggct agagccatat cggaaatatt gctaagcaat ctcaattcct     2820

tcaggcataa tgtgattttt tttttttttt gaagataact cccatctcca aatagtttag     2880

atgtagtttg ttttcacgat gtatgaagga gatgctctgt ttctttcttt caggcatttg     2940

attgcctctg acacagcttt gccttttaaa gcaataatta gggattaaaa taacaaaaac     3000

aaaacaaaag ccacctatag ccctttaaca cttaacgtgg cccctttact agcatgaaat     3060

gctggagaca tgtggtttcc taatttctcc attttggggg tggtgggagg ggggagggtg     3120

gccattatga ctcttatcat attaaaaagc caagcacaag tgattggttg aactgcagaa     3180

aagtgttctg tggtctctga gttgagcaaa actctaaatt gcaggcttcg tggttgaggg     3240

cctagtcagc tgaaagccac gcgtgtggta aaggctcagg catggcttgg agaacctagg     3300

aacacattag gagcctgcac ctaccagcct caccatacag ccattcaggg gaacccaaaa     3360

agtgccttac ccaaggaggg cccccagcag ctttccagga agtcgaatga agtcgctgtc     3420

ctcggggaac tggtcagctg aagtagcaac cggtagctga tgtcagtaga caacagaacc     3480

tgtggggacc tccaggaaac ctttgacatt ggaggctttc attaggcagg gccaacaaga     3540

gcagggaagg ccatgtaccc attggtatct gccattgtgt gtgagtttga gatccagccc     3600

tccttggagg atgtactgtg atcattcctg gtaccttagg gccaatccct aagtgtggct     3660

tcctaatcca ggccagggat cattcagtga taccaccagg ccaatcccag cattcctcct     3720

gcacaaagtg tttgtgtgtg gggggataga ttggggtggg gccaccttca tttgaatcct     3780

gagtcattct aagagttctg caagcttttg ccttcagcac cctatacccc ctcgctctct     3840

gttccttctc aggttgacct ttgtcccaat gcgggacagt ccagaggcag atggggacct     3900

atgtgtgcct ccaacctgcg ttttcctcag aattcatcct gactccctct gacacagatt     3960

gagggggggg ggaagaaacc caacccgcac caaagcaaaa cactttgcct tctaaaggct     4020

gtgcaccaag tagacgcaga tggtcagccc acctttgtgt ttccttaaga tggaaattgt     4080

aactgatgct atttattgtt tgtgtgtggt agcttgaagc acaccacggt ccatgtgttt     4140

gtctgatacc tatttcagca gcatttacaa aagccagtgt ctggttacac ttttcagttt     4200

tcattaatca acatgaaaat gttaccattg gtgccagctg caccctattt aattttttta     4260

agggcactat atttgtacat ttcgttttta atgttaaagg gcttcttaaa gtttacagta     4320

cagttatcaa gggaatagag gggatgcatt agtgcctaaa tgttattcta gtggctgcag     4380

gcagcaaccc agaagcagtt ttgaaaacag gttgtttccc tctgtcctcc cttatttggg     4440

aaaattcaag tgctttcttc acctttcagg cacctcacgg tgactcccgt tacttagagc     4500

agtctgtcgt cgtcttcttc ttcttcctct tcctcttcct cttcctcttc ctcttcctct     4560

tcctcttcct cttcctcttc ctcttcttct tcttcttctt cttcttcttc ttcttcttct     4620

tcctcctagg gtttaaaatc ccccttcctc ttcccttatc tcttaaactc ttcatttgca     4680

ctgggtcaca cgtatgattt gtggttttaa gaccaaagca atgtcttatt actcttctgg     4740

agccgtttat gtgtactaac caacccttcc ctccacttcc ctgggtttag atgcacacgg     4800

ttctcaaagg agcacaaaca tggccagatt cacagtggga cccacacagc catgttaaaa     4860

aaaaaaacaa aaaaaaacct cttcacttgt ctgagaattt taacctgggc cccaattgct     4920

aacgggcacc atggcttggg tttcaggtta gggaacgttg cccagtgagt aacagaaaga     4980

cttaactgat ttaattagtt tgccctcatc cttcactcca agaccctaag aaaccgatca     5040

gagaaacatc tccacaccat tagaggttga gaagggagga gccatgtggg ggttccctcc     5100

gctcggagga aaggcactga ctgacctagt tagagtggta gcagaagcac ccatggtatc     5160

tgagagagca ataaacaata aaagatgatc ctcccaagct tagaatttgt tgttcttaaa     5220

gaagacgatg catctaaaac aaagaatttt tttttctatg tgggaacttt cttcgttgtc     5280

tgtttacttc atgtttacaa ataattgttt gctttttaat gcagtacttt aaaaaatata     5340

tcagccaaaa ccataactta cagtaatttt tttaggtatt ctgaataaaa ttccatgtct     5400

tttgatatgt ctactgttct taggtttctg tggaacaaca acaacaacaa caacaaaatt     5460

gtagcatttt gtgtaaatac agctttcgtt cttatttttt atttttctga ttgctattgc     5520

ccaagatttg ctttctatgc acgtattgta caaattgtgc tttgtgccac aggtcatgat     5580

cgtggatgag tttactctga acttcaaagg gactatttgt attgtatgtt gcaactgtaa     5640

attgaattat ttggcatttc cccctctcat gattgtaata ttaatttgaa gtttgaattt     5700

aattttcaat aaaaaggctt tttttttcct tttggttttg                           5740


<210>  37
<211>  5904
<212>  DNA
<213>  Mus musculus

<400>  37
atgcttcatt cgcctcacaa acaaccacag aaccacaagt gcggtgcaaa ctttctccag       60

gaagactgca agaaggctct ggcgtttaaa tggttaatct ctgcaggtca ctaccagcca      120

ccgagaccaa ccgagtcagt gagtgctcta accacagtcc atgcaggaat agtaggtcct      180

tcaaatattt gctcactccg ttttgttttg tttccttgct tttcacatgt taccagctac      240

ataatttctt gacagaaaaa aataaatata aagtctatgt actccaggca tactgtacaa      300

ctaaaacagg gactgggtat ggtttgtatt ttcagtttaa ggctgcaagc agtatttaca      360

acagagggca caagttctat ctggaaaaaa aaggagggac tatggcgtca aacagcctct      420

tcagcgcagt gacaccgtgt cagcaaagct tcttttggga tccgagcacc agccggcgct      480

tcagcccccc ctccagcagc ctgcagcccg gcaagatgag cgacgtgagc ccggtggtgg      540

ctgcgcagca gcagcaacag cagcagcagc agcagcaaca gcagcagcaa caacagcaac      600

agcaacaaca gcagcagcag cagcagcagc aggaggcggc cgcagcagca gcggcggcag      660

cggcggcggc agcagcggcg gcggccgcag tgccccgatt gaggccgccg cacgacaacc      720

gcaccatggt ggagatcatc gcggaccacc cggccgaact ggtccgcacc gacagtccca      780

acttcctgtg ctccgtgctg ccctcgcact ggcggtgcaa caagaccctg cccgtggcct      840

tcaaggttgt agccctcgga gaggtaccag atgggactgt ggttaccgtc atggccggga      900

atgatgagaa ctactccgcc gagctccgaa atgcctccgc tgttatgaaa aaccaagtag      960

ccaggttcaa cgatctgaga tttgtgggcc ggagcggacg aggcaagagt ttcaccttga     1020

ccataacagt cttcacaaat cctccccaag tggccactta ccacagagct attaaagtga     1080

cagtggacgg tccccgggaa ccaagaaggc acagacagaa gcttgatgac tctaaaccta     1140

gtttgttctc tgatcgcctc agtgatttag ggcgcattcc tcatcccagt atgagagtag     1200

gtgtcccgcc tcagaaccca cggccctccc tgaactctgc accaagtcct tttaatccac     1260

aaggacagag tcagattaca gatcccaggc aggcacagtc ttccccaccg tggtcctatg     1320

accagtctta cccctcctat ctgagccaga tgacatcccc atccatccac tccaccacgc     1380

cgctgtcttc cacacggggc accgggctac ctgccatcac tgacgtgccc aggcgtattt     1440

cagatgatga cactgccacc tctgacttct gcctctggcc ttcctctctc agtaagaaga     1500

gccaggcagg tgcttcagaa ctgggccctt tttcagaccc caggcagttc ccaagcattt     1560

catccctcac tgagagccgc ttctccaacc cacgaatgca ctacccagcc acctttacct     1620

acaccccgcc agtcacgtca ggcatgtccc tcggcatgtc cgccaccact cactaccaca     1680

cgtacctgcc accaccctac cccggctctt cccaaagcca gagtggaccc ttccagacca     1740

gcagcactcc atatctctac tatggtactt cgtcagcatc ctatcagttc ccaatggtac     1800

ccgggggaga ccggtctcct tccaggatgg tcccaccatg caccaccacc tcgaatggca     1860

gcacgctatt aaatccaaat ttgcctaacc agaatgatgg tgttgacgct gacggaagcc     1920

acagcagttc cccaactgtt ttgaattcta gcggcagaat ggatgagtct gtttggcggc     1980

catattgaaa ttcgtcaacc atggcccagt ggcatggggg ccacatcccg catgtgttaa     2040

tatatacata tataaagaga gtgcctatat atgtatattg attagctaac tagaagattt     2100

ctcattcaat ccctagtcat gatcttgcaa ccctaagagg gtgggggcag tcataactgg     2160

gtttcatatt gtttactatt taagatgtcc cctttaccaa ggaacaaacc gtcaaaggtg     2220

ttgtctggtc tgttttcata agtgacctgt tcccacgccg gttcagagag gtggactctg     2280

ggtctgggag gaaggagaga cacttcctct ctgtgctttg aaaccacagc ctctgctgtg     2340

tggcagccgg tacactctgc agacccgctt acagagtcag atgtggtgca ctcagaaagg     2400

gacaagaggc agagtggctg cttctgtccg ctgccgtcca ctctgccgtc cacctgttcc     2460

aaagttttcc ttcagacttg ctgcaggtac tcatttgaac ttttgagttc actttttttt     2520

tttcctattc taagaaagtg acttcaaaaa tactgatcag gacagataat tttattttac     2580

cttttatatt ttctcacttc ccccatttaa ccaaaaagaa atcccgttcc ccctcccccg     2640

ttccttctgc ttctcccttt atgcaaactg aaaatggcaa tgccttatta ttatagccat     2700

aatggtatag tgtttgagtt ggctgtgtgt tatgtgtttt tttctttttt tttctttttt     2760

aaattatgaa tatgtgtaaa atctgaagta acttgctaac gtgaatggtc atataacttt     2820

aaagatatat ttataattat ttaatgacat ttggacattt ggaacatttc ttagtgtaat     2880

gatatgttga cttcggtctc taaaagtgtg cttcttcttc aataccaagt ttcttcagtg     2940

ggctagagcc atatcggaaa tattgctaag caatctcaat tccttcaggc ataatgtgat     3000

tttttttttt ttttgaagat aactcccatc tccaaatagt ttagatgtag tttgttttca     3060

cgatgtatga aggagatgct ctgtttcttt ctttcaggca tttgattgcc tctgacacag     3120

ctttgccttt taaagcaata attagggatt aaaataacaa aaacaaaaca aaagccacct     3180

atagcccttt aacacttaac gtggcccctt tactagcatg aaatgctgga gacatgtggt     3240

ttcctaattt ctccattttg ggggtggtgg gaggggggag ggtggccatt atgactctta     3300

tcatattaaa aagccaagca caagtgattg gttgaactgc agaaaagtgt tctgtggtct     3360

ctgagttgag caaaactcta aattgcaggc ttcgtggttg agggcctagt cagctgaaag     3420

ccacgcgtgt ggtaaaggct caggcatggc ttggagaacc taggaacaca ttaggagcct     3480

gcacctacca gcctcaccat acagccattc aggggaaccc aaaaagtgcc ttacccaagg     3540

agggccccca gcagctttcc aggaagtcga atgaagtcgc tgtcctcggg gaactggtca     3600

gctgaagtag caaccggtag ctgatgtcag tagacaacag aacctgtggg gacctccagg     3660

aaacctttga cattggaggc tttcattagg cagggccaac aagagcaggg aaggccatgt     3720

acccattggt atctgccatt gtgtgtgagt ttgagatcca gccctccttg gaggatgtac     3780

tgtgatcatt cctggtacct tagggccaat ccctaagtgt ggcttcctaa tccaggccag     3840

ggatcattca gtgataccac caggccaatc ccagcattcc tcctgcacaa agtgtttgtg     3900

tgtgggggga tagattgggg tggggccacc ttcatttgaa tcctgagtca ttctaagagt     3960

tctgcaagct tttgccttca gcaccctata ccccctcgct ctctgttcct tctcaggttg     4020

acctttgtcc caatgcggga cagtccagag gcagatgggg acctatgtgt gcctccaacc     4080

tgcgttttcc tcagaattca tcctgactcc ctctgacaca gattgagggg ggggggaaga     4140

aacccaaccc gcaccaaagc aaaacacttt gccttctaaa ggctgtgcac caagtagacg     4200

cagatggtca gcccaccttt gtgtttcctt aagatggaaa ttgtaactga tgctatttat     4260

tgtttgtgtg tggtagcttg aagcacacca cggtccatgt gtttgtctga tacctatttc     4320

agcagcattt acaaaagcca gtgtctggtt acacttttca gttttcatta atcaacatga     4380

aaatgttacc attggtgcca gctgcaccct atttaatttt tttaagggca ctatatttgt     4440

acatttcgtt tttaatgtta aagggcttct taaagtttac agtacagtta tcaagggaat     4500

agaggggatg cattagtgcc taaatgttat tctagtggct gcaggcagca acccagaagc     4560

agttttgaaa acaggttgtt tccctctgtc ctcccttatt tgggaaaatt caagtgcttt     4620

cttcaccttt caggcacctc acggtgactc ccgttactta gagcagtctg tcgtcgtctt     4680

cttcttcttc ctcttcctct tcctcttcct cttcctcttc ctcttcctct tcctcttcct     4740

cttcctcttc ttcttcttct tcttcttctt cttcttcttc ttcttcctcc tagggtttaa     4800

aatccccctt cctcttccct tatctcttaa actcttcatt tgcactgggt cacacgtatg     4860

atttgtggtt ttaagaccaa agcaatgtct tattactctt ctggagccgt ttatgtgtac     4920

taaccaaccc ttccctccac ttccctgggt ttagatgcac acggttctca aaggagcaca     4980

aacatggcca gattcacagt gggacccaca cagccatgtt aaaaaaaaaa acaaaaaaaa     5040

acctcttcac ttgtctgaga attttaacct gggccccaat tgctaacggg caccatggct     5100

tgggtttcag gttagggaac gttgcccagt gagtaacaga aagacttaac tgatttaatt     5160

agtttgccct catccttcac tccaagaccc taagaaaccg atcagagaaa catctccaca     5220

ccattagagg ttgagaaggg aggagccatg tgggggttcc ctccgctcgg aggaaaggca     5280

ctgactgacc tagttagagt ggtagcagaa gcacccatgg tatctgagag agcaataaac     5340

aataaaagat gatcctccca agcttagaat ttgttgttct taaagaagac gatgcatcta     5400

aaacaaagaa tttttttttc tatgtgggaa ctttcttcgt tgtctgttta cttcatgttt     5460

acaaataatt gtttgctttt taatgcagta ctttaaaaaa tatatcagcc aaaaccataa     5520

cttacagtaa tttttttagg tattctgaat aaaattccat gtcttttgat atgtctactg     5580

ttcttaggtt tctgtggaac aacaacaaca acaacaacaa aattgtagca ttttgtgtaa     5640

atacagcttt cgttcttatt ttttattttt ctgattgcta ttgcccaaga tttgctttct     5700

atgcacgtat tgtacaaatt gtgctttgtg ccacaggtca tgatcgtgga tgagtttact     5760

ctgaacttca aagggactat ttgtattgta tgttgcaact gtaaattgaa ttatttggca     5820

tttccccctc tcatgattgt aatattaatt tgaagtttga atttaatttt caataaaaag     5880

gctttttttt tccttttggt tttg                                            5904


<210>  38
<211>  5829
<212>  DNA
<213>  Mus musculus

<400>  38
ggcggaggag gcggcgcggg caagcgacgg cgccgcgagc tgggcagccg cgctctgctt       60

ggcggtggcg gacagcgagg agccacacgc accgccgaga tggactgctg aacctgcggg      120

gctccactac cgtactggaa cccggagcgg ggcgccagcg cacccaggac acggtgcccc      180

aaggggcccc tactgcaagc tgttaacttc aagtcccttg cggcggctgg gccaaacacg      240

cccccgcgtc ccgctcgttg cagccaccgc cagggactcc caagcctccc ggtggagatc      300

cgcgcctctc gggtgtcccc acccgctacc ccgactctgt ccggtctcca gtcgccggcc      360

cccagcagac tccgcccggc acacggcttc ctcgaacttg atttctcacc tcctctgtcc      420

cgtcacctcc atcctctttc cgcccccgtc tcgcctccac cccctcgatt tcctcctcct      480

cgccccccat ttccaccctc ctccccctcc cccggccact tcgctaactt gtggctgttg      540

tgatgcgtat tcctgtagat ccgagcacca gccggcgctt cagccccccc tccagcagcc      600

tgcagcccgg caagatgagc gacgtgagcc cggtggtggc tgcgcagcag cagcaacagc      660

agcagcagca gcagcaacag cagcagcaac aacagcaaca gcaacaacag cagcagcagc      720

agcagcagca ggaggcggcc gcagcagcag cggcggcagc ggcggcggca gcagcggcgg      780

cggccgcagt gccccgattg aggccgccgc acgacaaccg caccatggtg gagatcatcg      840

cggaccaccc ggccgaactg gtccgcaccg acagtcccaa cttcctgtgc tccgtgctgc      900

cctcgcactg gcggtgcaac aagaccctgc ccgtggcctt caaggttgta gccctcggag      960

aggtaccaga tgggactgtg gttaccgtca tggccgggaa tgatgagaac tactccgccg     1020

agctccgaaa tgcctccgct gttatgaaaa accaagtagc caggttcaac gatctgagat     1080

ttgtgggccg gagcggacga ggcaagagtt tcaccttgac cataacagtc ttcacaaatc     1140

ctccccaagt ggccacttac cacagagcta ttaaagtgac agtggacggt ccccgggaac     1200

caagaaatcc caggcaggca cagtcttccc caccgtggtc ctatgaccag tcttacccct     1260

cctatctgag ccagatgaca tccccatcca tccactccac cacgccgctg tcttccacac     1320

ggggcaccgg gctacctgcc atcactgacg tgcccaggcg tatttcagat gatgacactg     1380

ccacctctga cttctgcctc tggccttcct ctctcagtaa gaagagccag gcaggtgctt     1440

cagaactggg ccctttttca gaccccaggc agttcccaag catttcatcc ctcactgaga     1500

gccgcttctc caacccacga atgcactacc cagccacctt tacctacacc ccgccagtca     1560

cgtcaggcat gtccctcggc atgtccgcca ccactcacta ccacacgtac ctgccaccac     1620

cctaccccgg ctcttcccaa agccagagtg gacccttcca gaccagcagc actccatatc     1680

tctactatgg tacttcgtca gcatcctatc agttcccaat ggtacccggg ggagaccggt     1740

ctccttccag gatggtccca ccatgcacca ccacctcgaa tggcagcacg ctattaaatc     1800

caaatttgcc taaccagaat gatggtgttg acgctgacgg aagccacagc agttccccaa     1860

ctgttttgaa ttctagcggc agaatggatg agtctgtttg gcggccatat tgaaattcgt     1920

caaccatggc ccagtggcat gggggccaca tcccgcatgt gttaatatat acatatataa     1980

agagagtgcc tatatatgta tattgattag ctaactagaa gatttctcat tcaatcccta     2040

gtcatgatct tgcaacccta agagggtggg ggcagtcata actgggtttc atattgttta     2100

ctatttaaga tgtccccttt accaaggaac aaaccgtcaa aggtgttgtc tggtctgttt     2160

tcataagtga cctgttccca cgccggttca gagaggtgga ctctgggtct gggaggaagg     2220

agagacactt cctctctgtg ctttgaaacc acagcctctg ctgtgtggca gccggtacac     2280

tctgcagacc cgcttacaga gtcagatgtg gtgcactcag aaagggacaa gaggcagagt     2340

ggctgcttct gtccgctgcc gtccactctg ccgtccacct gttccaaagt tttccttcag     2400

acttgctgca ggtactcatt tgaacttttg agttcacttt ttttttttcc tattctaaga     2460

aagtgacttc aaaaatactg atcaggacag ataattttat tttacctttt atattttctc     2520

acttccccca tttaaccaaa aagaaatccc gttccccctc ccccgttcct tctgcttctc     2580

cctttatgca aactgaaaat ggcaatgcct tattattata gccataatgg tatagtgttt     2640

gagttggctg tgtgttatgt gtttttttct ttttttttct tttttaaatt atgaatatgt     2700

gtaaaatctg aagtaacttg ctaacgtgaa tggtcatata actttaaaga tatatttata     2760

attatttaat gacatttgga catttggaac atttcttagt gtaatgatat gttgacttcg     2820

gtctctaaaa gtgtgcttct tcttcaatac caagtttctt cagtgggcta gagccatatc     2880

ggaaatattg ctaagcaatc tcaattcctt caggcataat gtgatttttt tttttttttg     2940

aagataactc ccatctccaa atagtttaga tgtagtttgt tttcacgatg tatgaaggag     3000

atgctctgtt tctttctttc aggcatttga ttgcctctga cacagctttg ccttttaaag     3060

caataattag ggattaaaat aacaaaaaca aaacaaaagc cacctatagc cctttaacac     3120

ttaacgtggc ccctttacta gcatgaaatg ctggagacat gtggtttcct aatttctcca     3180

ttttgggggt ggtgggaggg gggagggtgg ccattatgac tcttatcata ttaaaaagcc     3240

aagcacaagt gattggttga actgcagaaa agtgttctgt ggtctctgag ttgagcaaaa     3300

ctctaaattg caggcttcgt ggttgagggc ctagtcagct gaaagccacg cgtgtggtaa     3360

aggctcaggc atggcttgga gaacctagga acacattagg agcctgcacc taccagcctc     3420

accatacagc cattcagggg aacccaaaaa gtgccttacc caaggagggc ccccagcagc     3480

tttccaggaa gtcgaatgaa gtcgctgtcc tcggggaact ggtcagctga agtagcaacc     3540

ggtagctgat gtcagtagac aacagaacct gtggggacct ccaggaaacc tttgacattg     3600

gaggctttca ttaggcaggg ccaacaagag cagggaaggc catgtaccca ttggtatctg     3660

ccattgtgtg tgagtttgag atccagccct ccttggagga tgtactgtga tcattcctgg     3720

taccttaggg ccaatcccta agtgtggctt cctaatccag gccagggatc attcagtgat     3780

accaccaggc caatcccagc attcctcctg cacaaagtgt ttgtgtgtgg ggggatagat     3840

tggggtgggg ccaccttcat ttgaatcctg agtcattcta agagttctgc aagcttttgc     3900

cttcagcacc ctataccccc tcgctctctg ttccttctca ggttgacctt tgtcccaatg     3960

cgggacagtc cagaggcaga tggggaccta tgtgtgcctc caacctgcgt tttcctcaga     4020

attcatcctg actccctctg acacagattg aggggggggg gaagaaaccc aacccgcacc     4080

aaagcaaaac actttgcctt ctaaaggctg tgcaccaagt agacgcagat ggtcagccca     4140

cctttgtgtt tccttaagat ggaaattgta actgatgcta tttattgttt gtgtgtggta     4200

gcttgaagca caccacggtc catgtgtttg tctgatacct atttcagcag catttacaaa     4260

agccagtgtc tggttacact tttcagtttt cattaatcaa catgaaaatg ttaccattgg     4320

tgccagctgc accctattta atttttttaa gggcactata tttgtacatt tcgtttttaa     4380

tgttaaaggg cttcttaaag tttacagtac agttatcaag ggaatagagg ggatgcatta     4440

gtgcctaaat gttattctag tggctgcagg cagcaaccca gaagcagttt tgaaaacagg     4500

ttgtttccct ctgtcctccc ttatttggga aaattcaagt gctttcttca cctttcaggc     4560

acctcacggt gactcccgtt acttagagca gtctgtcgtc gtcttcttct tcttcctctt     4620

cctcttcctc ttcctcttcc tcttcctctt cctcttcctc ttcctcttcc tcttcttctt     4680

cttcttcttc ttcttcttct tcttcttctt cctcctaggg tttaaaatcc cccttcctct     4740

tcccttatct cttaaactct tcatttgcac tgggtcacac gtatgatttg tggttttaag     4800

accaaagcaa tgtcttatta ctcttctgga gccgtttatg tgtactaacc aacccttccc     4860

tccacttccc tgggtttaga tgcacacggt tctcaaagga gcacaaacat ggccagattc     4920

acagtgggac ccacacagcc atgttaaaaa aaaaaacaaa aaaaaacctc ttcacttgtc     4980

tgagaatttt aacctgggcc ccaattgcta acgggcacca tggcttgggt ttcaggttag     5040

ggaacgttgc ccagtgagta acagaaagac ttaactgatt taattagttt gccctcatcc     5100

ttcactccaa gaccctaaga aaccgatcag agaaacatct ccacaccatt agaggttgag     5160

aagggaggag ccatgtgggg gttccctccg ctcggaggaa aggcactgac tgacctagtt     5220

agagtggtag cagaagcacc catggtatct gagagagcaa taaacaataa aagatgatcc     5280

tcccaagctt agaatttgtt gttcttaaag aagacgatgc atctaaaaca aagaattttt     5340

ttttctatgt gggaactttc ttcgttgtct gtttacttca tgtttacaaa taattgtttg     5400

ctttttaatg cagtacttta aaaaatatat cagccaaaac cataacttac agtaattttt     5460

ttaggtattc tgaataaaat tccatgtctt ttgatatgtc tactgttctt aggtttctgt     5520

ggaacaacaa caacaacaac aacaaaattg tagcattttg tgtaaataca gctttcgttc     5580

ttatttttta tttttctgat tgctattgcc caagatttgc tttctatgca cgtattgtac     5640

aaattgtgct ttgtgccaca ggtcatgatc gtggatgagt ttactctgaa cttcaaaggg     5700

actatttgta ttgtatgttg caactgtaaa ttgaattatt tggcatttcc ccctctcatg     5760

attgtaatat taatttgaag tttgaattta attttcaata aaaaggcttt ttttttcctt     5820

ttggttttg                                                             5829


<210>  39
<211>  5724
<212>  DNA
<213>  Mus musculus

<400>  39
ggcggaggag gcggcgcggg caagcgacgg cgccgcgagc tgggcagccg cgctctgctt       60

ggcggtggcg gacagcgagg agccacacgc accgccgaga tggactgctg aacctgcggg      120

gctccactac cgtactggaa cccggagcgg ggcgccagcg cacccaggac acggtgcccc      180

aaggggcccc tactgcaagc tgttaacttc aagtcccttg cggcggctgg gccaaacacg      240

cccccgcgtc ccgctcgttg cagccaccgc cagggactcc caagcctccc ggtggagatc      300

cgcgcctctc gggtgtcccc acccgctacc ccgactctgt ccggtctcca gtcgccggcc      360

cccagcagac tccgcccggc acacggcttc ctcgaacttg atttctcacc tcctctgtcc      420

cgtcacctcc atcctctttc cgcccccgtc tcgcctccac cccctcgatt tcctcctcct      480

cgccccccat ttccaccctc ctccccctcc cccggccact tcgctaactt gtggctgttg      540

tgatgcgtat tcctgtagat ccgagcacca gccggcgctt cagccccccc tccagcagcc      600

tgcagcccgg caagatgagc gacgtgagcc cggtggtggc tgcgcagcag cagcaacagc      660

agcagcagca gcagcaacag cagcagcaac aacagcaaca gcaacaacag cagcagcagc      720

agcagcagca ggaggcggcc gcagcagcag cggcggcagc ggcggcggca gcagcggcgg      780

cggccgcagt gccccgattg aggccgccgc acgacaaccg caccatggtg gagatcatcg      840

cggaccaccc ggccgaactg gtccgcaccg acagtcccaa cttcctgtgc tccgtgctgc      900

cctcgcactg gcggtgcaac aagaccctgc ccgtggcctt caaggttgta gccctcggag      960

aggtaccaga tgggactgtg gttaccgtca tggccgggaa tgatgagaac tactccgccg     1020

agctccgaaa tgcctccgct gttatgaaaa accaagtagc caggttcaac gatctgagat     1080

ttgtgggccg gagcggacga gatcccaggc aggcacagtc ttccccaccg tggtcctatg     1140

accagtctta cccctcctat ctgagccaga tgacatcccc atccatccac tccaccacgc     1200

cgctgtcttc cacacggggc accgggctac ctgccatcac tgacgtgccc aggcgtattt     1260

cagatgatga cactgccacc tctgacttct gcctctggcc ttcctctctc agtaagaaga     1320

gccaggcagg tgcttcagaa ctgggccctt tttcagaccc caggcagttc ccaagcattt     1380

catccctcac tgagagccgc ttctccaacc cacgaatgca ctacccagcc acctttacct     1440

acaccccgcc agtcacgtca ggcatgtccc tcggcatgtc cgccaccact cactaccaca     1500

cgtacctgcc accaccctac cccggctctt cccaaagcca gagtggaccc ttccagacca     1560

gcagcactcc atatctctac tatggtactt cgtcagcatc ctatcagttc ccaatggtac     1620

ccgggggaga ccggtctcct tccaggatgg tcccaccatg caccaccacc tcgaatggca     1680

gcacgctatt aaatccaaat ttgcctaacc agaatgatgg tgttgacgct gacggaagcc     1740

acagcagttc cccaactgtt ttgaattcta gcggcagaat ggatgagtct gtttggcggc     1800

catattgaaa ttcgtcaacc atggcccagt ggcatggggg ccacatcccg catgtgttaa     1860

tatatacata tataaagaga gtgcctatat atgtatattg attagctaac tagaagattt     1920

ctcattcaat ccctagtcat gatcttgcaa ccctaagagg gtgggggcag tcataactgg     1980

gtttcatatt gtttactatt taagatgtcc cctttaccaa ggaacaaacc gtcaaaggtg     2040

ttgtctggtc tgttttcata agtgacctgt tcccacgccg gttcagagag gtggactctg     2100

ggtctgggag gaaggagaga cacttcctct ctgtgctttg aaaccacagc ctctgctgtg     2160

tggcagccgg tacactctgc agacccgctt acagagtcag atgtggtgca ctcagaaagg     2220

gacaagaggc agagtggctg cttctgtccg ctgccgtcca ctctgccgtc cacctgttcc     2280

aaagttttcc ttcagacttg ctgcaggtac tcatttgaac ttttgagttc actttttttt     2340

tttcctattc taagaaagtg acttcaaaaa tactgatcag gacagataat tttattttac     2400

cttttatatt ttctcacttc ccccatttaa ccaaaaagaa atcccgttcc ccctcccccg     2460

ttccttctgc ttctcccttt atgcaaactg aaaatggcaa tgccttatta ttatagccat     2520

aatggtatag tgtttgagtt ggctgtgtgt tatgtgtttt tttctttttt tttctttttt     2580

aaattatgaa tatgtgtaaa atctgaagta acttgctaac gtgaatggtc atataacttt     2640

aaagatatat ttataattat ttaatgacat ttggacattt ggaacatttc ttagtgtaat     2700

gatatgttga cttcggtctc taaaagtgtg cttcttcttc aataccaagt ttcttcagtg     2760

ggctagagcc atatcggaaa tattgctaag caatctcaat tccttcaggc ataatgtgat     2820

tttttttttt ttttgaagat aactcccatc tccaaatagt ttagatgtag tttgttttca     2880

cgatgtatga aggagatgct ctgtttcttt ctttcaggca tttgattgcc tctgacacag     2940

ctttgccttt taaagcaata attagggatt aaaataacaa aaacaaaaca aaagccacct     3000

atagcccttt aacacttaac gtggcccctt tactagcatg aaatgctgga gacatgtggt     3060

ttcctaattt ctccattttg ggggtggtgg gaggggggag ggtggccatt atgactctta     3120

tcatattaaa aagccaagca caagtgattg gttgaactgc agaaaagtgt tctgtggtct     3180

ctgagttgag caaaactcta aattgcaggc ttcgtggttg agggcctagt cagctgaaag     3240

ccacgcgtgt ggtaaaggct caggcatggc ttggagaacc taggaacaca ttaggagcct     3300

gcacctacca gcctcaccat acagccattc aggggaaccc aaaaagtgcc ttacccaagg     3360

agggccccca gcagctttcc aggaagtcga atgaagtcgc tgtcctcggg gaactggtca     3420

gctgaagtag caaccggtag ctgatgtcag tagacaacag aacctgtggg gacctccagg     3480

aaacctttga cattggaggc tttcattagg cagggccaac aagagcaggg aaggccatgt     3540

acccattggt atctgccatt gtgtgtgagt ttgagatcca gccctccttg gaggatgtac     3600

tgtgatcatt cctggtacct tagggccaat ccctaagtgt ggcttcctaa tccaggccag     3660

ggatcattca gtgataccac caggccaatc ccagcattcc tcctgcacaa agtgtttgtg     3720

tgtgggggga tagattgggg tggggccacc ttcatttgaa tcctgagtca ttctaagagt     3780

tctgcaagct tttgccttca gcaccctata ccccctcgct ctctgttcct tctcaggttg     3840

acctttgtcc caatgcggga cagtccagag gcagatgggg acctatgtgt gcctccaacc     3900

tgcgttttcc tcagaattca tcctgactcc ctctgacaca gattgagggg ggggggaaga     3960

aacccaaccc gcaccaaagc aaaacacttt gccttctaaa ggctgtgcac caagtagacg     4020

cagatggtca gcccaccttt gtgtttcctt aagatggaaa ttgtaactga tgctatttat     4080

tgtttgtgtg tggtagcttg aagcacacca cggtccatgt gtttgtctga tacctatttc     4140

agcagcattt acaaaagcca gtgtctggtt acacttttca gttttcatta atcaacatga     4200

aaatgttacc attggtgcca gctgcaccct atttaatttt tttaagggca ctatatttgt     4260

acatttcgtt tttaatgtta aagggcttct taaagtttac agtacagtta tcaagggaat     4320

agaggggatg cattagtgcc taaatgttat tctagtggct gcaggcagca acccagaagc     4380

agttttgaaa acaggttgtt tccctctgtc ctcccttatt tgggaaaatt caagtgcttt     4440

cttcaccttt caggcacctc acggtgactc ccgttactta gagcagtctg tcgtcgtctt     4500

cttcttcttc ctcttcctct tcctcttcct cttcctcttc ctcttcctct tcctcttcct     4560

cttcctcttc ttcttcttct tcttcttctt cttcttcttc ttcttcctcc tagggtttaa     4620

aatccccctt cctcttccct tatctcttaa actcttcatt tgcactgggt cacacgtatg     4680

atttgtggtt ttaagaccaa agcaatgtct tattactctt ctggagccgt ttatgtgtac     4740

taaccaaccc ttccctccac ttccctgggt ttagatgcac acggttctca aaggagcaca     4800

aacatggcca gattcacagt gggacccaca cagccatgtt aaaaaaaaaa acaaaaaaaa     4860

acctcttcac ttgtctgaga attttaacct gggccccaat tgctaacggg caccatggct     4920

tgggtttcag gttagggaac gttgcccagt gagtaacaga aagacttaac tgatttaatt     4980

agtttgccct catccttcac tccaagaccc taagaaaccg atcagagaaa catctccaca     5040

ccattagagg ttgagaaggg aggagccatg tgggggttcc ctccgctcgg aggaaaggca     5100

ctgactgacc tagttagagt ggtagcagaa gcacccatgg tatctgagag agcaataaac     5160

aataaaagat gatcctccca agcttagaat ttgttgttct taaagaagac gatgcatcta     5220

aaacaaagaa tttttttttc tatgtgggaa ctttcttcgt tgtctgttta cttcatgttt     5280

acaaataatt gtttgctttt taatgcagta ctttaaaaaa tatatcagcc aaaaccataa     5340

cttacagtaa tttttttagg tattctgaat aaaattccat gtcttttgat atgtctactg     5400

ttcttaggtt tctgtggaac aacaacaaca acaacaacaa aattgtagca ttttgtgtaa     5460

atacagcttt cgttcttatt ttttattttt ctgattgcta ttgcccaaga tttgctttct     5520

atgcacgtat tgtacaaatt gtgctttgtg ccacaggtca tgatcgtgga tgagtttact     5580

ctgaacttca aagggactat ttgtattgta tgttgcaact gtaaattgaa ttatttggca     5640

tttccccctc tcatgattgt aatattaatt tgaagtttga atttaatttt caataaaaag     5700

gctttttttt tccttttggt tttg                                            5724


