                         SEQUENCE LISTING

<110>  QUEEN MARY UNIVERSITY OF LONDON
 
<120>  TREATMENT

<130>  N411842WO

<150>  GB 1718985.3
<151>  2017-11-16

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1
aagucuacaa aggucaccug u                                                 21


<210>  2
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2
aagucuacaa aggucaccug uccugucuc                                         29


<210>  3
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3
aaacagguga ccuuuguaga c                                                 21


<210>  4
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4
aaacagguga ccuguagacc cugucuc                                           27


<210>  5
<211>  943
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Ala Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ile Leu Val Pro Ser Ile Ala Ile Pro Leu 
                405                 410                 415     


Val Ile Ala Cys Leu Phe Phe Leu Val Cys Met Cys Arg Asn Lys Gln 
            420                 425                 430         


Lys Ala Ser Ala Ser Thr Pro Gln Arg Arg Gln Leu Met Ala Ser Pro 
        435                 440                 445             


Ser Gln Asp Met Glu Met Pro Leu Ile Asn Gln His Lys Gln Ala Lys 
    450                 455                 460                 


Leu Lys Glu Ile Ser Leu Ser Ala Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Asp Arg Phe Gly Lys Val Tyr Lys Gly His Leu Phe Gly Pro Ala 
                485                 490                 495     


Pro Gly Glu Gln Thr Gln Ala Val Ala Ile Lys Thr Leu Lys Asp Lys 
            500                 505                 510         


Ala Glu Gly Pro Leu Arg Glu Glu Phe Arg His Glu Ala Met Leu Arg 
        515                 520                 525             


Ala Arg Leu Gln His Pro Asn Val Val Cys Leu Leu Gly Val Val Thr 
    530                 535                 540                 


Lys Asp Gln Pro Leu Ser Met Ile Phe Ser Tyr Cys Ser His Gly Asp 
545                 550                 555                 560 


Leu His Glu Phe Leu Val Met Arg Ser Pro His Ser Asp Val Gly Ser 
                565                 570                 575     


Thr Asp Asp Asp Arg Thr Val Lys Ser Ala Leu Glu Pro Pro Asp Phe 
            580                 585                 590         


Val His Leu Val Ala Gln Ile Ala Ala Gly Met Glu Tyr Leu Ser Ser 
        595                 600                 605             


His His Val Val His Lys Asp Leu Ala Thr Arg Asn Val Leu Val Tyr 
    610                 615                 620                 


Asp Lys Leu Asn Val Lys Ile Ser Asp Leu Gly Leu Phe Arg Glu Val 
625                 630                 635                 640 


Tyr Ala Ala Asp Tyr Tyr Lys Leu Leu Gly Asn Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Ala Pro Glu Ala Ile Met Tyr Gly Lys Phe Ser Ile Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Tyr Gly Val Val Leu Trp Glu Val Phe Ser Tyr 
        675                 680                 685             


Gly Leu Gln Pro Tyr Cys Gly Tyr Ser Asn Gln Asp Val Val Glu Met 
    690                 695                 700                 


Ile Arg Asn Arg Gln Val Leu Pro Cys Pro Asp Asp Cys Pro Ala Trp 
705                 710                 715                 720 


Val Tyr Ala Leu Met Ile Glu Cys Trp Asn Glu Phe Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Ser Arg Leu Arg Ala Trp Gly Asn Leu 
            740                 745                 750         


Ser Asn Tyr Asn Ser Ser Ala Gln Thr Ser Gly Ala Ser Asn Thr Thr 
        755                 760                 765             


Gln Thr Ser Ser Leu Ser Thr Ser Pro Val Ser Asn Val Ser Asn Ala 
    770                 775                 780                 


Arg Tyr Val Gly Pro Lys Gln Lys Ala Pro Pro Phe Pro Gln Pro Gln 
785                 790                 795                 800 


Phe Ile Pro Met Lys Gly Gln Ile Arg Pro Met Val Pro Pro Pro Gln 
                805                 810                 815     


Leu Tyr Ile Pro Val Asn Gly Tyr Gln Pro Val Pro Ala Tyr Gly Ala 
            820                 825                 830         


Tyr Leu Pro Asn Phe Tyr Pro Val Gln Ile Pro Met Gln Met Ala Pro 
        835                 840                 845             


Gln Gln Val Pro Pro Gln Met Val Pro Lys Pro Ser Ser His His Ser 
    850                 855                 860                 


Gly Ser Gly Ser Thr Ser Thr Gly Tyr Val Thr Thr Ala Pro Ser Asn 
865                 870                 875                 880 


Thr Ser Met Ala Asp Arg Ala Ala Leu Leu Ser Glu Gly Ala Asp Asp 
                885                 890                 895     


Thr Gln Asn Ala Pro Glu Asp Gly Ala Gln Ser Thr Val Gln Glu Ala 
            900                 905                 910         


Glu Glu Glu Glu Glu Gly Ser Val Pro Glu Thr Glu Leu Leu Gly Asp 
        915                 920                 925             


Cys Asp Thr Leu Gln Val Asp Glu Ala Gln Val Gln Leu Glu Ala 
    930                 935                 940             


<210>  6
<211>  3310
<212>  DNA
<213>  Homo sapiens

<400>  6
ggacgcatcg tagaaagggg tggtggcgcc cgaccccgcg ccccggcccg aagctctgag       60

ggcttcccgg cccccactgc ctgcggcatg gcccggggct cggcgctccc gcggcggccg      120

ctgctgtgca tcccggccgt ctgggcggcc gccgcgcttc tgctctcagt gtcccggact      180

tcaggtgaag tggaggttct ggatccgaac gaccctttag gaccccttga tgggcaggac      240

ggcccgattc caactctgaa aggttacttt ctgaattttc tggagccagt aaacaatatc      300

accattgtcc aaggccagac ggcaattctg cactgcaagg tggcaggaaa cccaccccct      360

aacgtgcggt ggctaaagaa tgatgccccg gtggtgcagg agccgcggcg gatcatcatc      420

cggaagacag aatatggttc acgactgcga atccaggacc tggacacgac agacactggc      480

tactaccagt gcgtggccac caacgggatg aagaccatta ccgccactgg cgtcctgttt      540

gtgcggctgg gtccaacgca cagcccaaat cataactttc aggatgatta ccacgaggat      600

gggttctgcc agccttaccg gggaattgcc tgtgcacgct tcattggcaa ccggaccatt      660

tatgtggact cgcttcagat gcagggggag attgaaaacc gaatcacagc ggccttcacc      720

atgatcggca cgtctacgca cctgtcggac cagtgctcac agttcgccat cccatccttc      780

tgccacttcg tgtttcctct gtgcgacgcg cgctcccggg cacccaagcc gcgtgagctg      840

tgccgcgacg agtgcgaggt gctggagagc gacctgtgcc gccaggagta caccatcgcc      900

cgctccaacc cgctcatcct catgcggctt cagctgccca agtgtgaggc gctgcccatg      960

cctgagagcc ccgacgctgc caactgcatg cgcattggca tcccagccga gaggctgggc     1020

cgctaccatc agtgctataa cggctcaggc atggattaca gaggaacggc aagcaccacc     1080

aagtcaggcc accagtgcca gccgtgggcc ctgcagcacc cccacagcca ccacctgtcc     1140

agcacagact tccctgagct tggagggggg cacgcctact gccggaaccc cggaggccag     1200

atggagggcc cctggtgctt tacgcagaat aaaaacgtac gcatggaact gtgtgacgta     1260

ccctcgtgta gtccccgaga cagcagcaag atggggattc tgtacatctt ggtccccagc     1320

atcgcaattc cactggtcat cgcttgcctt ttcttcttgg tttgcatgtg ccggaataag     1380

cagaaggcat ctgcgtccac accgcagcgg cgacagctga tggcctcgcc cagccaagac     1440

atggaaatgc ccctcattaa ccagcacaaa caggccaaac tcaaagagat cagcctgtct     1500

gcggtgaggt tcatggagga gctgggagag gaccggtttg ggaaagtcta caaaggtcac     1560

ctgttcggcc ctgccccggg ggagcagacc caggctgtgg ccatcaaaac gctgaaggac     1620

aaagcggagg ggcccctgcg ggaggagttc cggcatgagg ctatgctgcg agcacggctg     1680

caacacccca acgtcgtctg cctgctgggc gtggtgacca aggaccagcc cctgagcatg     1740

atcttcagct actgttcgca cggcgacctc cacgaattcc tggtcatgcg ctcgccgcac     1800

tcggacgtgg gcagcaccga tgatgaccgc acggtgaagt ccgccctgga gccccccgac     1860

ttcgtgcacc ttgtggcaca gatcgcggcg gggatggagt acctatccag ccaccacgtg     1920

gttcacaagg acctggccac ccgcaatgtg ctagtgtacg acaagctgaa cgtgaagatc     1980

tcagacttgg gcctcttccg agaggtgtat gccgccgatt actacaagct gctggggaac     2040

tcgctgctgc ctatccgctg gatggcccca gaggccatca tgtacggcaa gttctccatc     2100

gactcagaca tctggtccta cggtgtggtc ctgtgggagg tcttcagcta cggcctgcag     2160

ccctactgcg ggtattccaa ccaggatgtg gtggagatga tccggaaccg gcaggtgctg     2220

ccttgccccg atgactgtcc cgcctgggtg tatgccctca tgatcgagtg ctggaacgag     2280

ttccccagcc ggcggccccg cttcaaggac atccacagcc ggctccgagc ctggggcaac     2340

ctttccaact acaacagctc ggcgcagacc tcgggggcca gcaacaccac gcagaccagc     2400

tccctgagca ccagcccagt gagcaatgtg agcaacgccc gctacgtggg gcccaagcag     2460

aaggccccgc ccttcccaca gccccagttc atccccatga agggccagat cagacccatg     2520

gtgcccccgc cgcagctcta catccccgtc aacggctacc agccggtgcc ggcctatggg     2580

gcctacctgc ccaacttcta cccggtgcag atcccaatgc agatggcccc gcagcaggtg     2640

cctcctcaga tggtccccaa gcccagctca caccacagtg gcagtggctc caccagcaca     2700

ggctacgtca ccacggcccc ctccaacaca tccatggcag acagggcagc cctgctctca     2760

gagggcgctg atgacacaca gaacgcccca gaagatgggg cccagagcac cgtgcaggaa     2820

gcagaggagg aggaggaagg ctctgtccca gagactgagc tgctggggga ctgtgacact     2880

ctgcaggtgg acgaggccca agtccagctg gaagcttgag tggcaccagg gcccagggtt     2940

cggggataga agccccgccg agaccccaca gggacctcag tcacctttga gaagacacca     3000

tactcagcaa tcacaagagc ccgccggcca gtgggcttgt ttgcagactg ggtgaggtgg     3060

agccctgctc ctctctgtcc tctgacacag ctgccctgcc taggagcacc caagccaggc     3120

agggggtctg gcagcacggc gtcctgggga gcaggacaca tggtcatccc cagggctgta     3180

tacattgatt ctggtggtag actggtagtg agcagcaaat gcctttcaag aaaataggtg     3240

gcagcttcac tccatgtcat atatggagtg aatatttcaa aacgttggga ataagggcct     3300

gcaaaaggca                                                            3310


<210>  7
<211>  944
<212>  PRT
<213>  Mus musculus

<400>  7

Met Ala Arg Gly Trp Val Arg Pro Ser Arg Val Pro Leu Cys Ala Arg 
1               5                   10                  15      


Ala Val Trp Thr Ala Ala Ala Leu Leu Leu Trp Thr Pro Trp Thr Ala 
            20                  25                  30          


Gly Glu Val Glu Asp Ser Glu Ala Ile Asp Thr Leu Gly Gln Pro Asp 
        35                  40                  45              


Gly Pro Asp Ser Pro Leu Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Val Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Leu Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Tyr Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Asp Gln Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr Gln Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Ala Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Asn Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Ala Asp Tyr Arg Gly Met Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His Arg Leu Ser Ser 
            340                 345                 350         


Thr Glu Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Val Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Val Glu Leu Cys Asp Val Pro Pro Cys Ser Pro Arg Asp Gly Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ile Leu Val Pro Ser Ile Ala Ile Pro Leu 
                405                 410                 415     


Val Ile Ala Cys Leu Phe Phe Leu Val Cys Met Cys Arg Asn Lys Gln 
            420                 425                 430         


Lys Ala Ser Ala Ser Thr Pro Gln Arg Arg Gln Leu Met Ala Ser Pro 
        435                 440                 445             


Ser Gln Asp Met Glu Met Pro Leu Ile Ser Gln His Lys Gln Ala Lys 
    450                 455                 460                 


Leu Lys Glu Ile Ser Leu Ser Thr Val Arg Phe Met Glu Glu Leu Gly 
465                 470                 475                 480 


Glu Asp Arg Phe Gly Lys Val Tyr Lys Gly His Leu Phe Gly Pro Ala 
                485                 490                 495     


Pro Gly Glu Pro Thr Gln Ala Val Ala Ile Lys Thr Leu Lys Asp Lys 
            500                 505                 510         


Ala Glu Gly Pro Leu Arg Glu Glu Phe Arg Gln Glu Ala Met Leu Arg 
        515                 520                 525             


Ala Arg Leu Gln His Pro Asn Ile Val Cys Leu Leu Gly Val Val Thr 
    530                 535                 540                 


Lys Asp Gln Pro Leu Ser Met Ile Phe Ser Tyr Cys Ser His Gly Asp 
545                 550                 555                 560 


Leu His Glu Phe Leu Val Met Arg Ser Pro His Ser Asp Val Gly Ser 
                565                 570                 575     


Thr Asp Asp Asp Arg Thr Val Lys Ser Ala Leu Glu Pro Pro Asp Phe 
            580                 585                 590         


Val His Val Val Ala Gln Ile Ala Ala Gly Met Glu Phe Leu Ser Ser 
        595                 600                 605             


His His Val Val His Lys Asp Leu Ala Thr Arg Asn Val Leu Val Tyr 
    610                 615                 620                 


Asp Lys Leu Asn Val Arg Ile Ser Asp Leu Gly Leu Phe Arg Glu Val 
625                 630                 635                 640 


Tyr Ser Ala Asp Tyr Tyr Lys Leu Met Gly Asn Ser Leu Leu Pro Ile 
                645                 650                 655     


Arg Trp Met Ser Pro Glu Ala Val Met Tyr Gly Lys Phe Ser Ile Asp 
            660                 665                 670         


Ser Asp Ile Trp Ser Tyr Gly Val Val Leu Trp Glu Val Phe Ser Tyr 
        675                 680                 685             


Gly Leu Gln Pro Tyr Cys Gly Tyr Ser Asn Gln Asp Val Val Glu Met 
    690                 695                 700                 


Ile Arg Ser Arg Gln Val Leu Pro Cys Pro Asp Asp Cys Pro Ala Trp 
705                 710                 715                 720 


Val Tyr Ala Leu Met Ile Glu Cys Trp Asn Glu Phe Pro Ser Arg Arg 
                725                 730                 735     


Pro Arg Phe Lys Asp Ile His Ser Arg Leu Arg Ser Trp Gly Asn Leu 
            740                 745                 750         


Ser Asn Tyr Asn Ser Ser Ala Gln Thr Ser Gly Ala Ser Asn Thr Thr 
        755                 760                 765             


Gln Thr Ser Ser Leu Ser Thr Ser Pro Val Ser Asn Val Ser Asn Ala 
    770                 775                 780                 


Arg Tyr Met Ala Pro Lys Gln Lys Ala Gln Pro Phe Pro Gln Pro Gln 
785                 790                 795                 800 


Phe Ile Pro Met Lys Gly Gln Ile Arg Pro Leu Val Pro Pro Ala Gln 
                805                 810                 815     


Leu Tyr Ile Pro Val Asn Gly Tyr Gln Pro Val Pro Ala Tyr Gly Ala 
            820                 825                 830         


Tyr Leu Pro Asn Phe Tyr Pro Val Gln Ile Pro Met Gln Met Ala Pro 
        835                 840                 845             


Gln Gln Val Pro Pro Gln Met Val Pro Lys Pro Ser Ser His His Ser 
    850                 855                 860                 


Gly Ser Gly Ser Thr Ser Thr Gly Tyr Val Thr Thr Ala Pro Ser Asn 
865                 870                 875                 880 


Thr Ser Val Ala Asp Arg Ala Ala Leu Leu Ser Glu Gly Thr Glu Asp 
                885                 890                 895     


Ala Gln Asn Ile Ala Glu Asp Val Ala Gln Ser Pro Val Gln Glu Ala 
            900                 905                 910         


Glu Glu Glu Glu Glu Gly Ser Val Pro Glu Thr Glu Leu Leu Gly Asp 
        915                 920                 925             


Asn Asp Thr Leu Gln Val Thr Glu Ala Ala His Val Gln Leu Glu Ala 
    930                 935                 940                 


<210>  8
<211>  2835
<212>  DNA
<213>  Mus musculus

<400>  8
atggctcggg gctgggtgcg gccgagccgt gtgcctctgt gcgcccgggc cgtctggacg       60

gctgcggcgc tcctgctctg gacaccctgg acggcaggtg aagtggaaga ttcggaggca      120

atcgacacct tgggacaacc tgatggaccg gacagcccac ttcccactct gaaaggctac      180

tttctgaatt ttctggagcc agtcaacaat atcaccattg ttcagggcca gacggcaatc      240

ctgcactgca aggtggcggg aaacccacct cccaatgtgc ggtggctgaa gaatgatgcc      300

ccggttgtgc aagagccacg aagggtcgtc atccggaaga cagaatacgg ctcccggctg      360

cggatccaag acctggacac aacagacaca ggctactacc agtgtgtggc taccaacggg      420

ctgaagacca tcactgccac tggggttcta tatgtgcggc tcggtccgac gcacagcccg      480

aaccacaatt ttcaggatga cgatcaggaa gatggcttct gccagccgta ccgagggatc      540

gcttgtgcgc gcttcattgg gaaccggact atttatgtgg actccctcca gatgcagggg      600

gagattgaaa accgaatcac agctgccttc accatgatcg gcacctccac gcaactgtca      660

gaccagtgtt cacagtttgc catcccatcc ttctgccact tcgtcttccc tctgtgcgac      720

gcatgctccc gggcgcccaa gcctcgcgaa ctgtgccggg atgaatgtga ggtgctggag      780

aacgacctgt gccgccagga gtacaccatc gcccgctcca acccgctcat cctcatgcgg      840

ctccagctgc ccaagtgcga agcgctgccc atgcccgaga gcccggatgc tgcgaactgc      900

atgcgcatcg ggatccccgc ggagaggctg ggtcgctacc accagtgcta caacggctcc      960

ggcgccgatt acagggggat ggccagtacc accaagtcag gccaccagtg tcagccttgg     1020

gctctgcagc acccccacag ccatcgccta tccagcacgg aattccctga gctgggagga     1080

ggccatgcct actgccggaa ccccgggggc cagatggaag gcccgtggtg ctttacgcag     1140

aataaaaacg tacgcgtgga actgtgtgac gtacccccgt gtagtccccg atatggcagc     1200

aagatgggga ttctgtacat cctggtcccc agcattgcta tccccctggt catcgcttgc     1260

ctgttcttcc tcgtctgcat gtgccgcaac aaacagaagg cttcggcctc caccccacag     1320

cgccggcagc tgatggcctc tcccagccag gacatggaga tgccactcat cagccagcac     1380

aaacaggcca aactcaaaga gatcagcttg tccacagtga ggttcatgga ggagctcggg     1440

gaggaccggt ttggcaaggt ctacaaaggc cacctgttcg ggcctgcccc aggagaacca     1500

acccaggccg tggccatcaa gacgctgaaa gacaaggctg aggggcccct gcgggaggag     1560

ttccggcaag aggcgatgct ccgggcccga ctgcagcacc ccaacatcgt ctgtctccta     1620

ggcgtcgtga ccaaggacca acccttgagc atgatcttca gctactgttc ccatggcgac     1680

cttcatgaat tcctggtcat gcgctcgccg cactccgatg tgggcagcac cgatgacgac     1740

cgcacagtga agtcagccct ggagcccccg gacttcgtgc acgtggtggc gcagatcgct     1800

gcggggatgg agttcctgtc cagccaccac gtgtgccata aggacctggc cacacgcaat     1860

gtgctggtgt acgacaagct gaacgtgagg atctcagact tgggcctctt ccgtgaggta     1920

tactccgcag attactacaa actcatgggc aattcactgc tgcccatccg ctggatgtcc     1980

cccgaggccg tcatgtatgg aaagttctcc atcgactctg acatctggtc ctacggtgtg     2040

gtcctctggg aggtctttag ctacggcctg cagccctact gtgggtactc caaccaggac     2100

gtggtggaga tgatccggag ccggcaggtg ctgccctgcc cggatgactg ccccgcctgg     2160

gtctatgccc tcatgattga atgctggaat gagttcccaa gccggaggcc ccgctttaag     2220

gacatccaca gccggctccg gtcctggggc aacctatcca actataatag ttccgcgcag     2280

acctcaggag ccagcaacac cacacagacc agctccctga gcaccagccc cgtaagcaat     2340

gtgagcaatg cccgctatat ggcccccaag cagaaggccc agcccttccc acagcctcag     2400

ttcatcccca tgaagggtca gatcagaccc ttggtgcccc ccgcacagct gtacatcccg     2460

gtgaacggct atcagccggt accggcatac ggggcctacc tgcccaactt ctacccagtc     2520

cagatcccca tgcagatggc cccacagcag gtgccccctc agatggtccc caagccgagc     2580

tcacaccaca gtggcagcgg ctccaccagc actggctacg tcaccacggc gccctccaat     2640

acatctgtgg cggacagggc ggccctactc tctgagggca ccgaggatgt acagaacatc     2700

gcggaagacg tggcccagag ccctgtgcag gaagcagagg aggaggagga ggggtctgtc     2760

cctgagactg aactcctggg agacaatgac acgctccagg tgaccgaggc ggctcatgtc     2820

cagcttgaag cctga                                                      2835


<210>  9
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9

Ser Ser Ser Thr Thr Thr Thr Thr Thr Thr Thr Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Leu Leu Leu 
            20                  25  


<210>  10
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Ala Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr 
                405     


<210>  11
<211>  1218
<212>  DNA
<213>  Homo sapiens

<400>  11
atggcccggg gctcggcgct cccgcggcgg ccgctgctgt gcatcccggc cgtctgggcg       60

gccgccgcgc ttctgctctc agtgtcccgg acttcaggtg aagtggaggt tctggatccg      120

aacgaccctt taggacccct tgatgggcag gacggcccga ttccaactct gaaaggttac      180

tttctgaatt ttctggagcc agtaaacaat atcaccattg tccaaggcca gacggcaatt      240

ctgcactgca aggtggcagg aaacccaccc cctaacgtgc ggtggctaaa gaatgatgcc      300

ccggtggtgc aggagccgcg gcggatcatc atccggaaga cagaatatgg ttcacgactg      360

cgaatccagg acctggacac gacagacact ggctactacc agtgcgtggc caccaacggg      420

atgaagacca ttaccgccac tggcgtcctg tttgtgcggc tgggtccaac gcacagccca      480

aatcataact ttcaggatga ttaccacgag gatgggttct gccagcctta ccggggaatt      540

gcctgtgcac gcttcattgg caaccggacc atttatgtgg actcgcttca gatgcagggg      600

gagattgaaa accgaatcac agcggccttc accatgatcg gcacgtctac gcacctgtcg      660

gaccagtgct cacagttcgc catcccatcc ttctgccact tcgtgtttcc tctgtgcgac      720

gcgcgctccc gggcacccaa gccgcgtgag ctgtgccgcg acgagtgcga ggtgctggag      780

agcgacctgt gccgccagga gtacaccatc gcccgctcca acccgctcat cctcatgcgg      840

cttcagctgc ccaagtgtga ggcgctgccc atgcctgaga gccccgacgc tgccaactgc      900

atgcgcattg gcatcccagc cgagaggctg ggccgctacc atcagtgcta taacggctca      960

ggcatggatt acagaggaac ggcaagcacc accaagtcag gccaccagtg ccagccgtgg     1020

gccctgcagc acccccacag ccaccacctg tccagcacag acttccctga gcttggaggg     1080

gggcacgcct actgccggaa ccccggaggc cagatggagg gcccctggtg ctttacgcag     1140

aataaaaacg tacgcatgga actgtgtgac gtaccctcgt gtagtccccg agacagcagc     1200

aagatgggga ttctgtac                                                   1218


<210>  12
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Gln Pro Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg 
1               5                   10                  15      


Thr Ile Tyr Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg 
            20                  25                  30          


Ile Thr Ala Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp 
        35                  40                  45              


Gln Cys Ser Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro 
    50                  55                  60                  


Leu Cys Asp Ala Arg Ser Arg Ala Pro Lys Pro Arg Glu Leu Cys Arg 
65                  70                  75                  80  


Asp Glu Cys Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr 
                85                  90                  95      


Ile Ala Arg Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys 
            100                 105                 110         


Cys Glu Ala Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn 
        115                 120                 125     


<210>  13
<211>  379
<212>  DNA
<213>  Homo sapiens

<400>  13
ctgccagcct taccggggaa ttgcctgtgc acgcttcatt ggcaaccgga ccatttatgt       60

ggactcgctt cagatgcagg gggagattga aaaccgaatc acagcggcct tcaccatgat      120

cggcacgtct acgcacctgt cggaccagtg ctcacagttc gccatcccat ccttctgcca      180

cttcgtgttt cctctgtgcg acgcgcgctc ccgggcaccc aagccgcgtg agctgtgccg      240

cgacgagtgc gaggtgctgg agagcgacct gtgccgccag gagtacacca tcgcccgctc      300

caacccgctc atcctcatgc ggcttcagct gcccaagtgt gaggcgctgc ccatgcctga      360

gagccccgac gctgccaac                                                   379


<210>  14
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14
agcagcagca ccaccaccac caccaccacc accctgctgc tgctgctgct gctgctgctg       60

ctgctgctgc tgctg                                                        75


<210>  15
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
gguucacgac ugcgaaucca ggaccugga                                         29


<210>  16
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16
aagaccauua ccgccacugg cguccuguu                                         29


<210>  17
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
auggauuaca gaggaacggc aagcaccac                                         29


<210>  18
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18
aagcagaagg caucugcguc cacaccgca                                         29


<210>  19
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19
ccuugagcau gaucuucagc uacuguucc                                         29


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20

Lys Asp Asp Asp Asp 
1               5   


<210>  21
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21
aaagatgatg atgat                                                        15


<210>  22
<211>  156
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22
agcagcagca ccaccaccac caccaccacc accctgctgc tgctgctgct gctgctgctg       60

ctgctgctgc tgctgaaaga tgatgatgat gaacaaaaac tcatctcaga agaggatctg      120

aatatgcata ccggtcatca tcaccatcac cattga                                156


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tobacco etch virus protease cleavage tag

<400>  23

Gly Gln Phe Tyr Leu Asn Glu 
1               5           


<210>  24
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tobacco etch virus protease cleavage tag

<400>  24
ggccagtttt atctgaacga a                                                 21


<210>  25
<211>  162
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tobacco etch virus protease cleavage tag

<400>  25
agcagcagca ccaccaccac caccaccacc accctgctgc tgctgctgct gctgctgctg       60

ctgctgctgc tgctgggcca gttttatctg aacgaagaac aaaaactcat ctcagaagag      120

gatctgaata tgcataccgg tcatcatcac catcaccatt ga                         162


<210>  26
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Ala Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ser Ser Ser Thr Thr Thr Thr Thr Thr Thr 
                405                 410                 415     


Thr Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu 
            420                 425                 430     


<210>  27
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27
atggcccggg gctcggcgct cccgcggcgg ccgctgctgt gcatcccggc cgtctgggcg       60

gccgccgcgc ttctgctctc agtgtcccgg acttcaggtg aagtggaggt tctggatccg      120

aacgaccctt taggacccct tgatgggcag gacggcccga ttccaactct gaaaggttac      180

tttctgaatt ttctggagcc agtaaacaat atcaccattg tccaaggcca gacggcaatt      240

ctgcactgca aggtggcagg aaacccaccc cctaacgtgc ggtggctaaa gaatgatgcc      300

ccggtggtgc aggagccgcg gcggatcatc atccggaaga cagaatatgg ttcacgactg      360

cgaatccagg acctggacac gacagacact ggctactacc agtgcgtggc caccaacggg      420

atgaagacca ttaccgccac tggcgtcctg tttgtgcggc tgggtccaac gcacagccca      480

aatcataact ttcaggatga ttaccacgag gatgggttct gccagcctta ccggggaatt      540

gcctgtgcac gcttcattgg caaccggacc atttatgtgg actcgcttca gatgcagggg      600

gagattgaaa accgaatcac agcggccttc accatgatcg gcacgtctac gcacctgtcg      660

gaccagtgct cacagttcgc catcccatcc ttctgccact tcgtgtttcc tctgtgcgac      720

gcgcgctccc gggcacccaa gccgcgtgag ctgtgccgcg acgagtgcga ggtgctggag      780

agcgacctgt gccgccagga gtacaccatc gcccgctcca acccgctcat cctcatgcgg      840

cttcagctgc ccaagtgtga ggcgctgccc atgcctgaga gccccgacgc tgccaactgc      900

atgcgcattg gcatcccagc cgagaggctg ggccgctacc atcagtgcta taacggctca      960

ggcatggatt acagaggaac ggcaagcacc accaagtcag gccaccagtg ccagccgtgg     1020

gccctgcagc acccccacag ccaccacctg tccagcacag acttccctga gcttggaggg     1080

gggcacgcct actgccggaa ccccggaggc cagatggagg gcccctggtg ctttacgcag     1140

aataaaaacg tacgcatgga actgtgtgac gtaccctcgt gtagtccccg agacagcagc     1200

aagatgggga ttctgtacag cagcagcacc accaccacca ccaccaccac cctgctgctg     1260

ctgctgctgc tgctgctgct gctgctgctg ctgaaagatg atgatgatga acaaaaactc     1320

atctcagaag aggatctgaa tatgcatacc ggtcatcatc accatcacca ttga           1374


<210>  28
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Ala Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ser Ser Ser Thr Thr Thr Thr Thr Thr Thr 
                405                 410                 415     


Thr Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Lys 
            420                 425                 430         


Asp Asp Asp Asp Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Met 
        435                 440                 445             


His Thr Gly His His His His His His 
    450                 455         


<210>  29
<211>  1374
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  29
atggcccggg gctcggcgct cccgcggcgg ccgctgctgt gcatcccggc cgtctgggcg       60

gccgccgcgc ttctgctctc agtgtcccgg acttcaggtg aagtggaggt tctggatccg      120

aacgaccctt taggacccct tgatgggcag gacggcccga ttccaactct gaaaggttac      180

tttctgaatt ttctggagcc agtaaacaat atcaccattg tccaaggcca gacggcaatt      240

ctgcactgca aggtggcagg aaacccaccc cctaacgtgc ggtggctaaa gaatgatgcc      300

ccggtggtgc aggagccgcg gcggatcatc atccggaaga cagaatatgg ttcacgactg      360

cgaatccagg acctggacac gacagacact ggctactacc agtgcgtggc caccaacggg      420

atgaagacca ttaccgccac tggcgtcctg tttgtgcggc tgggtccaac gcacagccca      480

aatcataact ttcaggatga ttaccacgag gatgggttct gccagcctta ccggggaatt      540

gcctgtgcac gcttcattgg caaccggacc atttatgtgg actcgcttca gatgcagggg      600

gagattgaaa accgaatcac agcggccttc accatgatcg gcacgtctac gcacctgtcg      660

gaccagtgct cacagttcgc catcccatcc ttctgccact tcgtgtttcc tctgtgcgac      720

gcgcgctccc gggcacccaa gccgcgtgag ctgtgccgcg acgagtgcga ggtgctggag      780

agcgacctgt gccgccagga gtacaccatc gcccgctcca acccgctcat cctcatgcgg      840

cttcagctgc ccaagtgtga ggcgctgccc atgcctgaga gccccgacgc tgccaactgc      900

atgcgcattg gcatcccagc cgagaggctg ggccgctacc atcagtgcta taacggctca      960

ggcatggatt acagaggaac ggcaagcacc accaagtcag gccaccagtg ccagccgtgg     1020

gccctgcagc acccccacag ccaccacctg tccagcacag acttccctga gcttggaggg     1080

gggcacgcct actgccggaa ccccggaggc cagatggagg gcccctggtg ctttacgcag     1140

aataaaaacg tacgcatgga actgtgtgac gtaccctcgt gtagtccccg agacagcagc     1200

aagatgggga ttctgtacag cagcagcacc accaccacca ccaccaccac cctgctgctg     1260

ctgctgctgc tgctgctgct gctgctgctg ctgaaagatg atgatgatga acaaaaactc     1320

atctcagaag aggatctgaa tatgcatacc ggtcatcatc accatcacca ttga           1374


<210>  30
<211>  459
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30

Met Ala Arg Gly Ser Ala Leu Pro Arg Arg Pro Leu Leu Cys Ile Pro 
1               5                   10                  15      


Ala Val Trp Ala Ala Ala Ala Leu Leu Leu Ser Val Ser Arg Thr Ser 
            20                  25                  30          


Gly Glu Val Glu Val Leu Asp Pro Asn Asp Pro Leu Gly Pro Leu Asp 
        35                  40                  45              


Gly Gln Asp Gly Pro Ile Pro Thr Leu Lys Gly Tyr Phe Leu Asn Phe 
    50                  55                  60                  


Leu Glu Pro Val Asn Asn Ile Thr Ile Val Gln Gly Gln Thr Ala Ile 
65                  70                  75                  80  


Leu His Cys Lys Val Ala Gly Asn Pro Pro Pro Asn Val Arg Trp Leu 
                85                  90                  95      


Lys Asn Asp Ala Pro Val Val Gln Glu Pro Arg Arg Ile Ile Ile Arg 
            100                 105                 110         


Lys Thr Glu Tyr Gly Ser Arg Leu Arg Ile Gln Asp Leu Asp Thr Thr 
        115                 120                 125             


Asp Thr Gly Tyr Tyr Gln Cys Val Ala Thr Asn Gly Met Lys Thr Ile 
    130                 135                 140                 


Thr Ala Thr Gly Val Leu Phe Val Arg Leu Gly Pro Thr His Ser Pro 
145                 150                 155                 160 


Asn His Asn Phe Gln Asp Asp Tyr His Glu Asp Gly Phe Cys Gln Pro 
                165                 170                 175     


Tyr Arg Gly Ile Ala Cys Ala Arg Phe Ile Gly Asn Arg Thr Ile Tyr 
            180                 185                 190         


Val Asp Ser Leu Gln Met Gln Gly Glu Ile Glu Asn Arg Ile Thr Ala 
        195                 200                 205             


Ala Phe Thr Met Ile Gly Thr Ser Thr His Leu Ser Asp Gln Cys Ser 
    210                 215                 220                 


Gln Phe Ala Ile Pro Ser Phe Cys His Phe Val Phe Pro Leu Cys Asp 
225                 230                 235                 240 


Ala Arg Ser Arg Ala Pro Lys Pro Arg Glu Leu Cys Arg Asp Glu Cys 
                245                 250                 255     


Glu Val Leu Glu Ser Asp Leu Cys Arg Gln Glu Tyr Thr Ile Ala Arg 
            260                 265                 270         


Ser Asn Pro Leu Ile Leu Met Arg Leu Gln Leu Pro Lys Cys Glu Ala 
        275                 280                 285             


Leu Pro Met Pro Glu Ser Pro Asp Ala Ala Asn Cys Met Arg Ile Gly 
    290                 295                 300                 


Ile Pro Ala Glu Arg Leu Gly Arg Tyr His Gln Cys Tyr Asn Gly Ser 
305                 310                 315                 320 


Gly Met Asp Tyr Arg Gly Thr Ala Ser Thr Thr Lys Ser Gly His Gln 
                325                 330                 335     


Cys Gln Pro Trp Ala Leu Gln His Pro His Ser His His Leu Ser Ser 
            340                 345                 350         


Thr Asp Phe Pro Glu Leu Gly Gly Gly His Ala Tyr Cys Arg Asn Pro 
        355                 360                 365             


Gly Gly Gln Met Glu Gly Pro Trp Cys Phe Thr Gln Asn Lys Asn Val 
    370                 375                 380                 


Arg Met Glu Leu Cys Asp Val Pro Ser Cys Ser Pro Arg Asp Ser Ser 
385                 390                 395                 400 


Lys Met Gly Ile Leu Tyr Ser Ser Ser Thr Thr Thr Thr Thr Thr Thr 
                405                 410                 415     


Thr Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Gly 
            420                 425                 430         


Gln Phe Tyr Leu Asn Glu Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
        435                 440                 445             


Asn Met His Thr Gly His His His His His His 
    450                 455                 


<210>  31
<211>  1380
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  31
atggcccggg gctcggcgct cccgcggcgg ccgctgctgt gcatcccggc cgtctgggcg       60

gccgccgcgc ttctgctctc agtgtcccgg acttcaggtg aagtggaggt tctggatccg      120

aacgaccctt taggacccct tgatgggcag gacggcccga ttccaactct gaaaggttac      180

tttctgaatt ttctggagcc agtaaacaat atcaccattg tccaaggcca gacggcaatt      240

ctgcactgca aggtggcagg aaacccaccc cctaacgtgc ggtggctaaa gaatgatgcc      300

ccggtggtgc aggagccgcg gcggatcatc atccggaaga cagaatatgg ttcacgactg      360

cgaatccagg acctggacac gacagacact ggctactacc agtgcgtggc caccaacggg      420

atgaagacca ttaccgccac tggcgtcctg tttgtgcggc tgggtccaac gcacagccca      480

aatcataact ttcaggatga ttaccacgag gatgggttct gccagcctta ccggggaatt      540

gcctgtgcac gcttcattgg caaccggacc atttatgtgg actcgcttca gatgcagggg      600

gagattgaaa accgaatcac agcggccttc accatgatcg gcacgtctac gcacctgtcg      660

gaccagtgct cacagttcgc catcccatcc ttctgccact tcgtgtttcc tctgtgcgac      720

gcgcgctccc gggcacccaa gccgcgtgag ctgtgccgcg acgagtgcga ggtgctggag      780

agcgacctgt gccgccagga gtacaccatc gcccgctcca acccgctcat cctcatgcgg      840

cttcagctgc ccaagtgtga ggcgctgccc atgcctgaga gccccgacgc tgccaactgc      900

atgcgcattg gcatcccagc cgagaggctg ggccgctacc atcagtgcta taacggctca      960

ggcatggatt acagaggaac ggcaagcacc accaagtcag gccaccagtg ccagccgtgg     1020

gccctgcagc acccccacag ccaccacctg tccagcacag acttccctga gcttggaggg     1080

gggcacgcct actgccggaa ccccggaggc cagatggagg gcccctggtg ctttacgcag     1140

aataaaaacg tacgcatgga actgtgtgac gtaccctcgt gtagtccccg agacagcagc     1200

aagatgggga ttctgtacag cagcagcacc accaccacca ccaccaccac cctgctgctg     1260

ctgctgctgc tgctgctgct gctgctgctg ctgggccagt tttatctgaa cgaagaacaa     1320

aaactcatct cagaagagga tctgaatatg cataccggtc atcatcacca tcaccattga     1380


