                         SEQUENCE LISTING

<110>  HIPRA SCIENTIFIC S.L.U.
 
<120>  Vaccine compositions for use against digital dermatitis in a

<130>  903 488

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  746
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T. pedis "PrtP" (Dentilisin Component PrtP-like Protein)


<220>
<221>  PEPTIDE
<222>  (1)..(746)

<400>  1

Met Lys Lys Ile Leu Val Leu Ser Ala Val Leu Ala Ile Leu Ala Gly 
1               5                   10                  15      


Ser Cys Ser Phe Asn Ile Asp Pro Gln Asn Ile Ser Ser Asn Glu Gln 
            20                  25                  30          


Arg Val Gln Ser Met Glu Ala Leu Tyr Gly Asn Ser Ser Ser Val Ile 
        35                  40                  45              


Pro Tyr Ala Pro Lys Asp Glu Asp Thr Val Asp Gly Phe Phe Ile Val 
    50                  55                  60                  


Lys Thr Lys Asp Gly Phe Asp Lys Thr Ala Phe Glu Glu Lys Gly Phe 
65                  70                  75                  80  


Thr Val Lys Gly Ala Leu Pro Leu Thr Gly Thr Gly Phe Thr Tyr Trp 
                85                  90                  95      


Tyr Leu Asn Lys Glu Gly Asn Asp Lys Lys Asn Leu Ser Val Ile Ser 
            100                 105                 110         


Ser Val Lys Gly Val Ile Ser Ala Glu Ser Asp Tyr Lys Val Glu Pro 
        115                 120                 125             


Pro Asp Gly Ile Lys Val Ala Lys Thr Val Asp Gly Gly Gly Leu Val 
    130                 135                 140                 


Asp Ile Ser Arg Leu Ile Asn Gly Asp Tyr Ser Gly Asp Pro Ile Ala 
145                 150                 155                 160 


Asn Asn Ser Asp Tyr Gly Leu Ser Ile Thr Glu Ala Leu Lys Ala Tyr 
                165                 170                 175     


Lys Glu Ile Gly Tyr Gly Asp Lys Thr Val Val Ala Gly Ile Ile Ala 
            180                 185                 190         


Thr Gly Ile Asn Met Thr His Lys Asp Phe Lys Asp Glu Asn Gly Asn 
        195                 200                 205             


Ser Ile Val Leu Tyr Ala Lys Ser Cys Val Lys Ser Asn Gly Gly Thr 
    210                 215                 220                 


Tyr Ile Gly Asn Gly Asn Pro Phe Thr Glu Ile Pro Ile Gly Glu Asn 
225                 230                 235                 240 


Trp Asp Lys Gly Ala Ala Gly Thr His Cys Ser Gly Thr Ile Cys Ala 
                245                 250                 255     


Arg Gly Asp Asn Asn Ala Gly Ile Ala Gly Val Ala Trp Lys Asn Thr 
            260                 265                 270         


Lys Leu Ile Ser Tyr Gln Ser Leu Asp Val Asp Gly Gly Gly Ser Ala 
        275                 280                 285             


Trp Ala Val Tyr Gly Ala Leu Ala Asp Leu Thr Arg Thr Val Asn Ile 
    290                 295                 300                 


Leu Arg Lys Pro Lys Ser Asp Arg Thr Leu Asp Glu Asn Asn Ala Leu 
305                 310                 315                 320 


Pro Ser Tyr Leu Lys Asn Glu Asp Phe Gln Ile Thr Gln Lys Thr Val 
                325                 330                 335     


Pro Val Asn Met Ser Leu Gly Gly Ser Tyr Gly Thr Glu Phe Ala Phe 
            340                 345                 350         


Ser Val Leu Thr Ala Ala Val Lys Asn Asn Ile Leu Pro Val Ile Ala 
        355                 360                 365             


Met Gly Asn Glu Gly Arg Tyr Thr Ala Ala Tyr Pro Ala Ala Phe Pro 
    370                 375                 380                 


Gly Met Leu Ala Val Gly Ala Thr Asn Gly Lys Asp Lys Lys Val His 
385                 390                 395                 400 


Phe Ser Asn Lys Gly Ala Trp Ile Ser Ile Ser Ala Pro Gly Asp Gly 
                405                 410                 415     


Ile Lys Ser Cys Gly Ile Ser Gly Asp Asp Asp Tyr Glu Thr Met Ser 
            420                 425                 430         


Gly Thr Ala Met Ala Thr Pro Phe Val Thr Gly Val Ile Ser Tyr Leu 
        435                 440                 445             


Leu Ser Phe Asn Asn Ala His Asn Leu Thr Pro Tyr Gln Ile Lys Ser 
    450                 455                 460                 


Leu Leu Glu Lys Thr Ala Asp Lys Val Asp Gly Ala Val Ser Phe Thr 
465                 470                 475                 480 


Glu Gly Tyr Gly His Gly Arg Val Asn Val Tyr Asn Ala Ala Lys Ala 
                485                 490                 495     


Ile Arg Glu Asn Ser Ile Pro Gln Val Asn Glu Ile Tyr Ser Glu Gly 
            500                 505                 510         


Ser Val Tyr Val Glu Val Lys Asn Asn Asn Glu Val Ile Ala Ser Lys 
        515                 520                 525             


Ile Ser Leu Val Asp Glu Glu Thr Lys Val Pro Leu Ala Tyr Val Ala 
    530                 535                 540                 


Gly Leu Gly Asn Asn Pro Val Val Glu Phe Lys Gly Leu Val Lys Gly 
545                 550                 555                 560 


Lys Ser Tyr Ser Val Tyr Ala Ser Leu Leu Lys Tyr Ala Lys Lys Glu 
                565                 570                 575     


Thr Phe Thr Ala Asp Gly Ser Asp Lys Thr Val Thr Ile Gln Phe Asn 
            580                 585                 590         


Lys Asn Leu Ala Trp Val Ser Thr Val Pro Ser Leu His Tyr Asn Gly 
        595                 600                 605             


Gly Asn Glu Gln Pro Asp Thr Lys Ile Ile Val Phe Lys Ala Asp Ser 
    610                 615                 620                 


Ser Gly Asn Leu Ser Arg Ser Pro Ser Pro Ile Leu Ile Tyr Asp Lys 
625                 630                 635                 640 


Asp Tyr Leu Asp Thr Ala Tyr Phe Glu Tyr Glu Ser Gly Ala Glu Tyr 
                645                 650                 655     


Tyr Ala Glu Ile Thr Gly Leu Lys Asp Glu Gln Gly Ile Phe Arg Gly 
            660                 665                 670         


Gly Asn Tyr Val Val Lys Ile Gly Leu Thr Pro Leu Asp Leu Asn Gly 
        675                 680                 685             


Glu Asp Ile Ile Asp Gly Ser Arg Val Ala Ser Asp Asn Asp Thr His 
    690                 695                 700                 


Glu Asp Asp Asp Glu Pro Asp Lys Ala Lys Leu Lys Gly Asn Ala Trp 
705                 710                 715                 720 


Glu Lys Lys Tyr Ala Cys Asn Leu Ala Ala His Gly Thr Asn Asn Glu 
                725                 730                 735     


Asp Ile Asp Phe Phe Tyr Ile Lys Met Pro 
            740                 745     


<210>  2
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PrtP mature protein (PrtPM), T.pedis


<220>
<221>  PEPTIDE
<222>  (1)..(346)

<400>  2

Gly Asp Pro Ile Ala Asn Asn Ser Asp Tyr Gly Leu Ser Ile Thr Glu 
1               5                   10                  15      


Ala Leu Lys Ala Tyr Lys Glu Ile Gly Tyr Gly Asp Lys Thr Val Val 
            20                  25                  30          


Ala Gly Ile Ile Ala Thr Gly Ile Asn Met Thr His Lys Asp Phe Lys 
        35                  40                  45              


Asp Glu Asn Gly Asn Ser Ile Val Leu Tyr Ala Lys Ser Cys Val Lys 
    50                  55                  60                  


Ser Asn Gly Gly Thr Tyr Ile Gly Asn Gly Asn Pro Phe Thr Glu Ile 
65                  70                  75                  80  


Pro Ile Gly Glu Asn Trp Asp Lys Gly Ala Ala Gly Thr His Cys Ser 
                85                  90                  95      


Gly Thr Ile Cys Ala Arg Gly Asp Asn Asn Ala Gly Ile Ala Gly Val 
            100                 105                 110         


Ala Trp Lys Asn Thr Lys Leu Ile Ser Tyr Gln Ser Leu Asp Val Asp 
        115                 120                 125             


Gly Gly Gly Ser Ala Trp Ala Val Tyr Gly Ala Leu Ala Asp Leu Thr 
    130                 135                 140                 


Arg Thr Val Asn Ile Leu Arg Lys Pro Lys Ser Asp Arg Thr Leu Asp 
145                 150                 155                 160 


Glu Asn Asn Ala Leu Pro Ser Tyr Leu Lys Asn Glu Asp Phe Gln Ile 
                165                 170                 175     


Thr Gln Lys Thr Val Pro Val Asn Met Ser Leu Gly Gly Ser Tyr Gly 
            180                 185                 190         


Thr Glu Phe Ala Phe Ser Val Leu Thr Ala Ala Val Lys Asn Asn Ile 
        195                 200                 205             


Leu Pro Val Ile Ala Met Gly Asn Glu Gly Arg Tyr Thr Ala Ala Tyr 
    210                 215                 220                 


Pro Ala Ala Phe Pro Gly Met Leu Ala Val Gly Ala Thr Asn Gly Lys 
225                 230                 235                 240 


Asp Lys Lys Val His Phe Ser Asn Lys Gly Ala Trp Ile Ser Ile Ser 
                245                 250                 255     


Ala Pro Gly Asp Gly Ile Lys Ser Cys Gly Ile Ser Gly Asp Asp Asp 
            260                 265                 270         


Tyr Glu Thr Met Ser Gly Thr Ala Met Ala Thr Pro Phe Val Thr Gly 
        275                 280                 285             


Val Ile Ser Tyr Leu Leu Ser Phe Asn Asn Ala His Asn Leu Thr Pro 
    290                 295                 300                 


Tyr Gln Ile Lys Ser Leu Leu Glu Lys Thr Ala Asp Lys Val Asp Gly 
305                 310                 315                 320 


Ala Val Ser Phe Thr Glu Gly Tyr Gly His Gly Arg Val Asn Val Tyr 
                325                 330                 335     


Asn Ala Ala Lys Ala Ile Arg Glu Asn Ser 
            340                 345     


<210>  3
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   TlyC, T. pedis


<220>
<221>  PEPTIDE
<222>  (1)..(261)

<400>  3

Met Gly Leu Phe Asp Lys Phe Lys Lys Lys Pro Asn Val Ser Gln Ile 
1               5                   10                  15      


Leu Lys Asn Gly Leu Asn Asp Glu Lys Arg Asp Met Ile Arg Gly Ile 
            20                  25                  30          


Val Asp Leu Ser Asp Thr Ala Val Lys Glu Val Met Ile Pro Arg Ile 
        35                  40                  45              


Asp Val Asp Phe Leu Ser Leu Asp Thr Pro Gly Asn Glu Ile Leu Asp 
    50                  55                  60                  


Lys Ile Ser Glu Ser Gly His Ser Arg Phe Pro Val Tyr Glu Asp Ser 
65                  70                  75                  80  


Ile Asp Asn Val Ile Gly Ile Leu Tyr Val Lys Asp Ile Leu Lys Leu 
                85                  90                  95      


Leu Pro Lys Asn Glu Lys Ile Asp Leu Lys Lys Val Val Arg Lys Ala 
            100                 105                 110         


Phe Phe Val Pro Glu Ser Lys Arg Ile Asp Asp Leu Leu Arg Glu Phe 
        115                 120                 125             


Lys Arg Arg His Leu His Ile Ala Ile Ala Val Asp Glu Tyr Gly Gly 
    130                 135                 140                 


Thr Ser Gly Ile Val Cys Met Glu Asp Ile Ile Glu Glu Ile Val Gly 
145                 150                 155                 160 


Asp Ile Gln Asp Glu Phe Asp Asn Glu Gly Glu Asp Ile Thr Lys Ile 
                165                 170                 175     


Gly Glu Gly Val Trp Leu Cys Asp Ala Arg Ile Asp Leu Asp Asp Leu 
            180                 185                 190         


Lys Glu Ala Ile Asp Ala Glu Asp Leu Pro Ala Asp Glu Phe Glu Thr 
        195                 200                 205             


Leu Gly Gly Phe Val Phe Asp Leu Phe Gly Lys Ile Pro Val Lys Tyr 
    210                 215                 220                 


Glu Lys Ala Val Trp Gln Asn Tyr Asp Phe Ile Val Gln Asp Met Asp 
225                 230                 235                 240 


Gly His Lys Val Lys Thr Val Lys Ile Ile Leu Asn Lys Glu Ala Leu 
                245                 250                 255     


Lys Pro Glu Ala Glu 
            260     


<210>  4
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MSP, T. pedis


<220>
<221>  PEPTIDE
<222>  (1)..(566)

<400>  4

Met Lys Lys Ile Leu Ser Ile Leu Ile Ala Leu Val Leu Val Gly Gly 
1               5                   10                  15      


Ala Val Phe Ala Gln Asp Ala Pro Glu Met Pro Ala Pro Val Phe Lys 
            20                  25                  30          


Gly Ser Ala Thr Leu Ser Trp Gly Ile Asp Leu Gly Tyr Gly Thr Asp 
        35                  40                  45              


Lys Tyr Gly Ser Ala Leu Ile Ser His Gly Phe Leu Asn Glu Ala Thr 
    50                  55                  60                  


Ala Ser Val Ser Leu Pro Phe Val Lys Ser Gly Ser Lys Lys Gly Glu 
65                  70                  75                  80  


Gly Asp Val Tyr Ala Leu Ile Asn Leu Asp Gly Val Lys Leu Gly Leu 
                85                  90                  95      


Glu Ala Asp Leu Lys Glu Ala Lys Ala Thr Gly Lys Ile Asp Lys Val 
            100                 105                 110         


Glu Ala Lys Ile Val Phe Tyr Gly Ala Tyr Ile Thr Val Tyr Asn Ala 
        115                 120                 125             


Pro Glu Met Lys Thr Lys Tyr Ala Ala Asp Ala Thr Ser Leu Ile Asn 
    130                 135                 140                 


Asp Asp Asn Phe Gly Ile Phe Asn Ser Gly Phe Gly Gly Tyr Gly Thr 
145                 150                 155                 160 


Lys Ile Gly Tyr Ala Asn Pro Asp Leu Met Asp Leu Asp Val Gly Ile 
                165                 170                 175     


Lys Phe Thr Ser Asn Gly Ser Trp Lys Asp Arg Asp Gly Ser Leu Gly 
            180                 185                 190         


Ala Glu Tyr Val Lys Thr Val Thr Val Lys Ala Asn Arg Val Asn Gly 
        195                 200                 205             


Thr Gly Thr Val His Leu Glu Asp Gly Gln Glu Leu Arg Asp Met Ser 
    210                 215                 220                 


Gly Lys Val Val Glu Arg Gly Pro Gly Trp Lys Arg Val Pro Ser Gly 
225                 230                 235                 240 


Gln Tyr Met Ile Tyr Arg Ser Ala Tyr Tyr Arg Tyr Arg Met Asn Gly 
                245                 250                 255     


His Tyr Gly Leu Gly Ile Asp Phe His Met Ala Pro Val Asp Lys Tyr 
            260                 265                 270         


Leu Thr Val Asp Ala Asn Phe Asn Met Thr Phe Asp Thr Ala Gly Ser 
        275                 280                 285             


Tyr Arg Thr Asp Val Glu Ser Asn Phe Asp Asp Met Arg Val Met Asn 
    290                 295                 300                 


Val Gly Ala Met Ile Lys Ser Glu Pro Ile Asp Gly Leu Met Phe Lys 
305                 310                 315                 320 


Leu Gly Phe Asp Gly Gly His Ala Phe Lys Lys Ala Ser Asp Ala Ser 
                325                 330                 335     


Ala Pro Leu Phe Ala Trp Ala Leu Gly Phe Gly Thr Glu Tyr Lys Asp 
            340                 345                 350         


Ser Arg Ala Gly Thr Ile Asn Ala Gly Leu Tyr Val Ser Ser Asp Gly 
        355                 360                 365             


Thr Pro Tyr Gly Asn Ala Gly Ile Phe Asp Pro Tyr Lys Leu Asn Phe 
    370                 375                 380                 


Val Pro Asp Gly Lys Gly Gly Phe Lys Glu Glu Lys Arg Pro Asp Gly 
385                 390                 395                 400 


Thr Arg Pro Gly Arg Gly Ile Thr Asp Ile Ala Phe Thr Val Gly Tyr 
                405                 410                 415     


Ser Gly Leu Pro Ala Val Glu Gly Leu Asp Leu His Ala Arg Leu Asn 
            420                 425                 430         


Val Phe Gly Leu Leu Ser Lys Ile Ser Lys Glu Glu Arg Ala Met Gly 
        435                 440                 445             


Glu Leu Ile Pro Leu Gly Leu Asn Val Gly Ala Gly Tyr Lys Ala Met 
    450                 455                 460                 


Leu Thr Asp Ser Ile Trp Ile Lys Pro Tyr Ala Asp Leu Trp Gly Glu 
465                 470                 475                 480 


Thr Asn Ser Asp Ile Tyr Ser Asp Asp Thr Pro Lys Ser Lys Gln Lys 
                485                 490                 495     


Leu Tyr Phe Gly Leu Ala Tyr Lys Val Gly Leu Ser Val Ser Pro Met 
            500                 505                 510         


Glu Arg Leu Thr Ile Asp Leu Asn Trp Ser His Gly Lys Ala Phe Asn 
        515                 520                 525             


Pro Asp Val Leu Met Gly Thr Gly Ser Met Phe Gly Leu Gly Gln Trp 
    530                 535                 540                 


Arg Ser Thr Pro Phe Gln His Lys Ala Asp Asn Gly Arg Phe Val Val 
545                 550                 555                 560 


Ser Ala Lys Ile Thr Tyr 
                565     


<210>  5
<211>  434
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OrfC, T. pedis


<220>
<221>  PEPTIDE
<222>  (1)..(434)

<400>  5

Met Gln Lys Ile Lys Lys Lys Leu Ser Phe Val Phe Phe Leu Phe Thr 
1               5                   10                  15      


Phe Ser Val Phe Ala Glu Phe Asn Phe Asp Leu Ile Val Gln Pro Phe 
            20                  25                  30          


Thr Gly Thr Glu Phe Phe Val Asp Gly Lys Thr Val Lys Pro Leu Val 
        35                  40                  45              


Leu Glu Lys Asp Asn Thr Leu Ala Lys Val Arg Leu Ile Leu Lys Asp 
    50                  55                  60                  


Ser Ala Ser Ala Ile Glu Val Lys Asn Lys Gly Phe Arg Thr Val Asn 
65                  70                  75                  80  


Leu Thr Asp Glu Leu Ile Arg Leu Lys Asn Asp Val Gly Lys Thr Ala 
                85                  90                  95      


Asp Leu Lys Ala Pro Phe Ser Ile Lys Ala Leu Ala Ile Leu Ser Arg 
            100                 105                 110         


Lys Glu Ser Lys Phe Asp Thr Lys Ala Phe Phe Pro Thr Gly Arg Gln 
        115                 120                 125             


Pro Lys Ser Val Thr Phe Val Asn Ser Asp Thr Val Ala Val Ala Leu 
    130                 135                 140                 


Leu Asp Gly Asn Gly Ala Asp Ile Ile Asn Ile Glu Thr Gly Glu Lys 
145                 150                 155                 160 


Lys Arg Ile Ser Pro Pro Lys Glu Tyr Ala Glu Lys Leu Gly Phe Val 
                165                 170                 175     


Glu Ala Leu Val Leu Lys Asn Lys Asn Glu Leu Trp Ile Ser Gln Met 
            180                 185                 190         


Pro Thr Ala Leu Ile His Val Phe Asn Leu Thr Thr Phe Glu Tyr Lys 
        195                 200                 205             


Thr Ala Val Lys Thr Ser Gly Lys Trp Ser Lys Val Met Ala Tyr Asn 
    210                 215                 220                 


Pro Leu Thr Asp Arg Val Tyr Leu Ser Asn Trp Gln Thr Phe Asp Ile 
225                 230                 235                 240 


Ser Val Ile Asn Thr Glu Thr Tyr Ser Glu Glu Lys Lys Ile Lys Thr 
                245                 250                 255     


Lys Ala Val Pro Arg Gly Met Ala Phe Ser Glu Asp Gly Lys Phe Ile 
            260                 265                 270         


Tyr Cys Ala Gln Phe Glu Asp Ala Ala Gly Asn Ser Asn Cys Arg Leu 
        275                 280                 285             


Val Lys Lys Glu Leu Asp Thr Phe Lys Thr Val Ser Glu Ser Gly Met 
    290                 295                 300                 


Lys Gly Ala Lys Arg His Ile Val Thr Asp Tyr Lys Gln Gly Arg Leu 
305                 310                 315                 320 


Tyr Val Ser Asp Met Leu Asn Ala Val Ile Glu Val Tyr Ser Leu Lys 
                325                 330                 335     


Asp Glu Ser Leu Ile Lys Thr Val Lys Val Phe Ser His Pro Asn Thr 
            340                 345                 350         


Ile Gln Leu Ser Pro Asp Gly Lys Phe Leu Tyr Val Ser Cys Arg Gly 
        355                 360                 365             


Pro Asn Asn Pro Asp Lys Gly Tyr Leu Tyr Lys Gly Tyr Val Met Gly 
    370                 375                 380                 


Arg Leu Asp Ile Ile Asp Thr Glu Thr Leu Thr Arg Ile Glu Ser Val 
385                 390                 395                 400 


Glu Ala Gly Asn Gln Pro Thr Gly Leu Asp Ile Ser Pro Asp Gly Lys 
                405                 410                 415     


Thr Ile Val Leu Ser Asp Phe Leu Asp Asn Arg Ile Arg Val Phe Lys 
            420                 425                 430         


Lys Asn 
        


<210>  6
<211>  622
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PrtP, T. vincentii


<220>
<221>  PEPTIDE
<222>  (1)..(622)

<400>  6

Met Ile Lys Gln Lys Lys Phe Arg Phe Thr Leu Phe Phe Ile Thr Ser 
1               5                   10                  15      


Ala Leu Ala Ala Val Phe Ala Gly Cys Ala Met Gly Phe Val Asn Asn 
            20                  25                  30          


Ser Ala Lys Ser Asp Gly Thr Gly Ser Val His Gly Thr Ala Asp Ser 
        35                  40                  45              


Asn Thr Val Phe Asn Ser Lys Trp Ile Ile Ser Gln Gln Glu Arg His 
    50                  55                  60                  


Asp Lys Gly Thr Val Val Arg Glu Gly Tyr Ser Ile Val Lys Thr Val 
65                  70                  75                  80  


Asp Ser Phe Asn Pro Asp Ser Phe Thr Ala Leu Asn Gly Ser Val Ala 
                85                  90                  95      


Ala Thr Gln Asp Leu His Asp Gly Tyr Leu Tyr Phe Leu Ile Lys Thr 
            100                 105                 110         


Glu Ser Asp Ala Ala Gln Phe Arg Thr Ala Val Arg Thr Leu Glu Gly 
        115                 120                 125             


Val Leu Tyr Ala Gln Pro Asp Tyr His Tyr Asp Ala Pro Ala Ala Met 
    130                 135                 140                 


Val Asp Asn Thr Ala Arg Pro Pro Val Arg Asn Arg Gly Ala Ala Gly 
145                 150                 155                 160 


Lys Gly Thr Leu Gly Thr Ala Asp Gly Asn Leu Asp Asn Asp Pro Lys 
                165                 170                 175     


Ala Ala Leu Ala Asp Trp Gly Leu Thr Ala Thr Gly Ala Leu Glu Ala 
            180                 185                 190         


Phe Lys Arg Tyr Asp Ala Lys Tyr Pro Val Leu Ala Ala Ile Ile Asp 
        195                 200                 205             


Thr Gly Val Asn Ser Leu His Glu Asp Phe Tyr Asp Lys Asn Asn Lys 
    210                 215                 220                 


Ser Ile Ile Leu Tyr Ala Lys Ser Ser Leu His Arg Gly Asp Val Thr 
225                 230                 235                 240 


Gln Tyr Thr Asn Pro Ile Pro Ile Ser Leu Asp Glu Asn Trp Asp Asn 
                245                 250                 255     


His Gly His Gly Thr His Cys Ser Gly Thr Ile Ala Ala Val Gly Asn 
            260                 265                 270         


Asn Gly Ile Gly Ile Cys Gly Val Ser His Ala Asn Thr Lys Leu Ile 
        275                 280                 285             


Thr Tyr Arg Gly Leu Asp Ala Ser Gly Gly Asp Thr Tyr Ala Thr Tyr 
    290                 295                 300                 


Ser Cys Leu Gly Asp Leu Ala Glu Ile Ile Thr Glu Leu Arg Lys Glu 
305                 310                 315                 320 


Pro Gly Ser Arg Asn Ser Ala Val Phe Ala Gly Leu Pro Pro Asp Val 
                325                 330                 335     


Ile Asn Tyr Pro Gln Leu Arg Gln Lys Thr Val Pro Val Asn Leu Ser 
            340                 345                 350         


Leu Gly Gly Pro Ala Gly His Pro Tyr Glu Val Glu Met Met Asn Lys 
        355                 360                 365             


Ala Leu Ala Ala Gly Val Leu Pro Val Ile Ala Met Gly Asn Asp Gly 
    370                 375                 380                 


Lys Thr Leu Ala Glu Tyr Pro Ala Ala Leu Gln Gly Ile Leu Ala Val 
385                 390                 395                 400 


Gly Ala Thr Thr Met Asp Asp Thr Arg Ala Ala Phe Ser Asn Gly Gly 
                405                 410                 415     


Thr Trp Met Ser Val Cys Ala Pro Gly Glu Ser Ile Tyr Ser Cys Gly 
            420                 425                 430         


Asn Gly Gly Gln Asn Trp Ala Asn Ser His Ser Pro Asp Val Lys Ser 
        435                 440                 445             


Ser Tyr Arg Trp Met Ser Gly Thr Ser Met Ala Thr Pro Phe Val Thr 
    450                 455                 460                 


Gly Val Val Thr Tyr Leu Leu Ser Ile Asn Pro Asp Leu Ser Pro Tyr 
465                 470                 475                 480 


Gln Ile Lys Ala Leu Leu Glu Asn Thr Ala Asp Lys Ile Asp Arg Gly 
                485                 490                 495     


Ser Pro Tyr Gly Gln Tyr Asp Ser Arg Gly Phe Ser Lys Trp Tyr Gly 
            500                 505                 510         


Tyr Gly Arg Val Asn Val Leu Lys Ala Thr Glu Ala Leu Val Thr Gly 
        515                 520                 525             


Ser Asn Ile Pro Ala Glu Gly Ser Val Tyr Ser Glu Lys Ala Val Met 
    530                 535                 540                 


Ile Thr Leu Lys Lys Ala Gly Ala Ala Gln Lys Lys Thr Pro Val Trp 
545                 550                 555                 560 


Leu Tyr Glu Lys Ala Thr Gly Ile Cys Ala Ala Val Gly Leu Thr Asp 
                565                 570                 575     


Glu Thr Asn Gly Ile Val Arg Phe Tyr Gly Leu Arg Thr Gly Leu Glu 
            580                 585                 590         


Tyr Glu Ile Gly Val Asn Asp Ala Gly Thr Tyr Lys Thr Tyr Ile Ile 
        595                 600                 605             


Thr Ala Thr Asn Asp Ser Asp Ile Asp Tyr Thr Phe Leu Leu 
    610                 615                 620         


<210>  7
<211>  358
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PrtP mature protein (PrtPM), T. vincentii


<220>
<221>  PEPTIDE
<222>  (1)..(358)

<400>  7

Asn Asp Pro Lys Ala Ala Leu Ala Asp Trp Gly Leu Thr Ala Thr Gly 
1               5                   10                  15      


Ala Leu Glu Ala Phe Lys Arg Tyr Asp Ala Lys Tyr Pro Val Leu Ala 
            20                  25                  30          


Ala Ile Ile Asp Thr Gly Val Asn Ser Leu His Glu Asp Phe Tyr Asp 
        35                  40                  45              


Lys Asn Asn Lys Ser Ile Ile Leu Tyr Ala Lys Ser Ser Leu His Arg 
    50                  55                  60                  


Gly Asp Val Thr Gln Tyr Thr Asn Pro Ile Pro Ile Ser Leu Asp Glu 
65                  70                  75                  80  


Asn Trp Asp Asn His Gly His Gly Thr His Cys Ser Gly Thr Ile Ala 
                85                  90                  95      


Ala Val Gly Asn Asn Gly Ile Gly Ile Cys Gly Val Ser His Ala Asn 
            100                 105                 110         


Thr Lys Leu Ile Thr Tyr Arg Gly Leu Asp Ala Ser Gly Gly Asp Thr 
        115                 120                 125             


Tyr Ala Thr Tyr Ser Cys Leu Gly Asp Leu Ala Glu Ile Ile Thr Glu 
    130                 135                 140                 


Leu Arg Lys Glu Pro Gly Ser Arg Asn Ser Ala Val Phe Ala Gly Leu 
145                 150                 155                 160 


Pro Pro Asp Val Ile Asn Tyr Pro Gln Leu Arg Gln Lys Thr Val Pro 
                165                 170                 175     


Val Asn Leu Ser Leu Gly Gly Pro Ala Gly His Pro Tyr Glu Val Glu 
            180                 185                 190         


Met Met Asn Lys Ala Leu Ala Ala Gly Val Leu Pro Val Ile Ala Met 
        195                 200                 205             


Gly Asn Asp Gly Lys Thr Leu Ala Glu Tyr Pro Ala Ala Leu Gln Gly 
    210                 215                 220                 


Ile Leu Ala Val Gly Ala Thr Thr Met Asp Asp Thr Arg Ala Ala Phe 
225                 230                 235                 240 


Ser Asn Gly Gly Thr Trp Met Ser Val Cys Ala Pro Gly Glu Ser Ile 
                245                 250                 255     


Tyr Ser Cys Gly Asn Gly Gly Gln Asn Trp Ala Asn Ser His Ser Pro 
            260                 265                 270         


Asp Val Lys Ser Ser Tyr Arg Trp Met Ser Gly Thr Ser Met Ala Thr 
        275                 280                 285             


Pro Phe Val Thr Gly Val Val Thr Tyr Leu Leu Ser Ile Asn Pro Asp 
    290                 295                 300                 


Leu Ser Pro Tyr Gln Ile Lys Ala Leu Leu Glu Asn Thr Ala Asp Lys 
305                 310                 315                 320 


Ile Asp Arg Gly Ser Pro Tyr Gly Gln Tyr Asp Ser Arg Gly Phe Ser 
                325                 330                 335     


Lys Trp Tyr Gly Tyr Gly Arg Val Asn Val Leu Lys Ala Thr Glu Ala 
            340                 345                 350         


Leu Val Thr Gly Ser Asn 
        355             


<210>  8
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hemolysin III, T. phagedenis


<220>
<221>  PEPTIDE
<222>  (1)..(216)

<400>  8

Met Thr Asn Lys Ile Lys Arg Arg Tyr Thr Val Gly Glu Glu Ile Ala 
1               5                   10                  15      


Asn Ala Ile Thr His Gly Val Gly Val Gly Leu Ser Ile Ala Ala Leu 
            20                  25                  30          


Val Leu Leu Ile Val Arg Ala Asn Arg Tyr Ala Pro Pro Glu Leu Lys 
        35                  40                  45              


Ala Gly Tyr Ile Val Gly Phe Ser Ile Phe Gly Ala Ser Leu Ile Ile 
    50                  55                  60                  


Leu Tyr Leu Phe Ser Thr Leu Tyr His Ala Leu Pro Leu Gly Ala Lys 
65                  70                  75                  80  


Lys Val Phe Gln Ile Phe Asp His Cys Ser Ile Tyr Ile Leu Ile Ala 
                85                  90                  95      


Gly Thr Tyr Thr Ala Phe Cys Leu Thr Ala Leu His Gly Ala Ile Gly 
            100                 105                 110         


Trp Thr Ile Phe Gly Ile Ile Trp Gly Phe Ala Ile Ala Gly Ile Val 
        115                 120                 125             


Leu Tyr Ala Ile Phe Gln Asn Lys Phe Pro Ile Phe Ser Leu Ile Thr 
    130                 135                 140                 


Tyr Ile Val Met Gly Trp Ile Ile Ile Phe Ala Ala Arg Pro Leu Lys 
145                 150                 155                 160 


Ser Gln Leu Pro Ser Ile Ser Phe Leu Phe Leu Ile Leu Gly Gly Ile 
                165                 170                 175     


Val Tyr Thr Ala Gly Cys Ile Phe Phe Ala Leu Lys Lys Ile Arg Trp 
            180                 185                 190         


Met His Thr Ile Trp His Phe Phe Val Leu Gly Gly Ser Ile Leu His 
        195                 200                 205             


Phe Phe Ser Met Tyr Tyr Ser Leu 
    210                 215     


<210>  9
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Apr2, D. nodosus


<220>
<221>  PEPTIDE
<222>  (1)..(601)

<400>  9

Met Lys Arg Phe Ile Met Asn Lys Met Ala Leu Val Val Cys Ala Ala 
1               5                   10                  15      


Leu Val Gly Gln Val Ala Ser Ala Glu Thr Met Val Asn Tyr Ala Ser 
            20                  25                  30          


Ala Lys Ala Ile Gly Lys Gln Pro Ala Gly Ser Val Arg Phe Ile Val 
        35                  40                  45              


Lys Tyr Lys Asp Asn Ser Gln Ser Ser Lys Asp Leu Lys Asn Arg Ser 
    50                  55                  60                  


Thr Thr Lys Val Met Ala Asn Gly Met Gln Val Ala Gly Phe Asn Ala 
65                  70                  75                  80  


Gln Phe Val Arg Met Thr Gly Ala Gly Ala Gly Ile Phe Ser Val Pro 
                85                  90                  95      


Asp Leu Lys Thr Thr Lys Glu Ala His Leu Val Met Asp Thr Ile Ala 
            100                 105                 110         


Ser Asn Pro Asp Val Glu Phe Val Glu Val Asp Arg Ile Ala Arg Pro 
        115                 120                 125             


Thr Ala Ala Pro Asn Asp Gln His Tyr Arg Glu Gln Trp His Tyr Phe 
    130                 135                 140                 


Asp Arg Tyr Gly Val Lys Ala Asp Lys Val Trp Asp Met Gly Phe Thr 
145                 150                 155                 160 


Gly Gln Asn Val Val Val Ala Val Val Asp Thr Gly Ile Leu His His 
                165                 170                 175     


Arg Asp Leu Asn Ala Asn Val Leu Pro Gly Tyr Asp Phe Ile Ser Asn 
            180                 185                 190         


Ser Gln Ile Ser Leu Asp Gly Asp Gly Arg Asp Ala Asp Pro Phe Asp 
        195                 200                 205             


Glu Gly Asp Trp Phe Asp Asn Trp Ala Cys Gly Gly Arg Pro Asp Pro 
    210                 215                 220                 


Arg Lys Glu Arg Ser Asp Ser Ser Trp His Gly Ser His Val Ala Gly 
225                 230                 235                 240 


Thr Ile Ala Ala Val Thr Asn Asn Arg Ile Gly Val Ala Gly Val Ala 
                245                 250                 255     


Tyr Gly Ala Lys Val Val Pro Val Arg Ala Leu Gly Arg Cys Gly Gly 
            260                 265                 270         


Tyr Asp Ser Asp Ile Ser Asp Gly Leu Tyr Trp Ala Ala Gly Gly Arg 
        275                 280                 285             


Ile Ala Gly Ile Pro Glu Asn Arg Asn Pro Ala Lys Val Ile Asn Met 
    290                 295                 300                 


Ser Leu Gly Ser Asp Gly Gln Cys Ser Tyr Asn Ala Gln Thr Met Ile 
305                 310                 315                 320 


Asp Arg Ala Thr Arg Leu Gly Ala Leu Val Val Val Ala Ala Gly Asn 
                325                 330                 335     


Glu Asn Gln Asn Ala Ser Asn Thr Trp Pro Thr Ser Cys Asn Asn Val 
            340                 345                 350         


Leu Ser Val Gly Ala Thr Thr Ser Arg Gly Ile Arg Ala Ser Phe Ser 
        355                 360                 365             


Asn Tyr Gly Val Asp Val Asp Leu Ala Ala Pro Gly Gln Asp Ile Leu 
    370                 375                 380                 


Ser Thr Val Asp Ser Gly Thr Arg Arg Pro Val Ser Asp Ala Tyr Ser 
385                 390                 395                 400 


Phe Met Ala Gly Thr Ser Met Ala Thr Pro His Val Ser Gly Val Ala 
                405                 410                 415     


Ala Leu Val Ile Ser Ala Ala Asn Ser Val Asn Lys Asn Leu Thr Pro 
            420                 425                 430         


Ala Glu Leu Lys Asp Val Leu Val Ser Thr Thr Ser Pro Phe Asn Gly 
        435                 440                 445             


Arg Leu Asp Arg Ala Leu Gly Ser Gly Ile Val Asp Ala Glu Ala Ala 
    450                 455                 460                 


Val Asn Ser Val Leu Gly Asn Glu Gly Asn Asn Gly Arg Asp Asp Arg 
465                 470                 475                 480 


Arg Asp Asn Val Ala Pro Val Glu Asn Ala Arg Asn Tyr Ala Asn Asn 
                485                 490                 495     


Ser Ile Lys Phe Ile Arg Asp Tyr Arg Leu Thr Ser Ser Val Ile Glu 
            500                 505                 510         


Val Glu Gly Arg Ser Gly Ala Ala Asn Gly Lys Ile Asn Leu Ala Leu 
        515                 520                 525             


Asp Ile Arg His Gly Asn Arg Ser Gln Leu Ser Ile Gln Leu Thr Ser 
    530                 535                 540                 


Pro Ala Gly His Val Tyr His Ile Asn His Asp Gly Ala Arg Arg Pro 
545                 550                 555                 560 


Asn Leu Ser Gly Thr Val Glu Ile Pro Val Gln Asn Glu Gln Ile Asn 
                565                 570                 575     


Gly Ala Trp Val Leu Gln Val Gly Asp His Gly Arg Gly Ala Thr Gly 
            580                 585                 590         


Tyr Ile Lys Ser Trp Ser Leu Thr Leu 
        595                 600     


<210>  10
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Apr2 benign mature protein (Apr2BM), D. nodosus


<220>
<221>  PEPTIDE
<222>  (1)..(335)

<400>  10

Ala Ala Pro Asn Asp Gln His Tyr Arg Glu Gln Trp His Tyr Phe Asp 
1               5                   10                  15      


Arg Tyr Gly Val Lys Ala Asp Lys Val Trp Asp Met Gly Phe Thr Gly 
            20                  25                  30          


Gln Asn Val Val Val Ala Val Val Ala Thr Gly Ile Leu His His Arg 
        35                  40                  45              


Asp Leu Asn Ala Asn Val Leu Pro Gly Tyr Asp Phe Ile Ser Asn Ser 
    50                  55                  60                  


Gln Ile Ser Leu Asp Gly Asp Gly Arg Asp Ala Asp Pro Phe Asp Glu 
65                  70                  75                  80  


Gly Asp Trp Phe Asp Asn Trp Ala Cys Gly Gly Arg Pro Asp Pro Arg 
                85                  90                  95      


Lys Glu Arg Ser Asp Ser Ser Trp Ala Gly Ser His Val Ala Gly Thr 
            100                 105                 110         


Ile Ala Ala Val Thr Asn Asn Arg Ile Gly Val Ala Gly Val Ala Tyr 
        115                 120                 125             


Gly Ala Lys Val Val Pro Val Arg Ala Leu Gly Arg Cys Gly Gly Tyr 
    130                 135                 140                 


Asp Ser Asp Ile Ser Asp Gly Leu Tyr Trp Ala Ala Gly Gly Arg Ile 
145                 150                 155                 160 


Ala Gly Ile Pro Glu Asn Arg Asn Pro Ala Lys Val Ile Asn Met Ser 
                165                 170                 175     


Leu Gly Ser Asp Gly Gln Cys Ser Tyr Asn Ala Gln Thr Met Ile Asp 
            180                 185                 190         


Arg Ala Thr Arg Leu Gly Ala Leu Val Val Val Ala Ala Gly Asn Glu 
        195                 200                 205             


Asn Gln Asn Ala Ser Asn Thr Trp Pro Thr Ser Cys Asn Asn Val Leu 
    210                 215                 220                 


Ser Val Gly Ala Thr Thr Ser Arg Gly Ile Arg Ala Ser Phe Ser Asn 
225                 230                 235                 240 


Tyr Gly Val Asp Val Asp Leu Ala Ala Pro Gly Gln Asp Ile Leu Ser 
                245                 250                 255     


Thr Val Asp Ser Gly Thr Arg Arg Pro Val Ser Asp Ala Tyr Ser Phe 
            260                 265                 270         


Met Ala Gly Thr Ala Met Ala Thr Pro His Val Ser Gly Val Ala Ala 
        275                 280                 285             


Leu Val Ile Ser Ala Ala Asn Ser Val Asn Lys Asn Leu Thr Pro Ala 
    290                 295                 300                 


Glu Leu Lys Asp Val Leu Val Ser Thr Thr Ser Pro Phe Asn Gly Arg 
305                 310                 315                 320 


Leu Asp Arg Ala Leu Gly Ser Gly Ile Val Asp Ala Glu Ala Ala 
                325                 330                 335 


<210>  11
<211>  603
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bpr, D. nodosus


<220>
<221>  PEPTIDE
<222>  (1)..(603)

<400>  11

Met Asn Leu Ser Asn Ile Ser Ala Val Lys Val Leu Thr Leu Val Val 
1               5                   10                  15      


Ser Ala Ala Ile Ala Gly Gln Val Cys Ala Ala Glu Ser Ile Val Asn 
            20                  25                  30          


Tyr Glu Ser Ala Asn Ala Ile Ser Lys Gln Pro Glu Gly Ser Val Arg 
        35                  40                  45              


Phe Ile Val Lys Tyr Lys Asp Gly Thr Pro Ser Ser Gln Gly Leu Lys 
    50                  55                  60                  


Thr Arg Ser Thr Thr Lys Val Met Ala Ser Gly Met Gln Val Ala Gly 
65                  70                  75                  80  


Phe Glu Ala Gln Phe Val Arg Thr Thr Gly Leu Gly Ala Gly Ile Phe 
                85                  90                  95      


Ala Val Pro Glu Leu Lys Thr Thr Lys Glu Ala His Leu Val Met Asp 
            100                 105                 110         


Thr Ile Ala Ser Asn Pro Asp Val Glu Phe Val Glu Val Asp Arg Leu 
        115                 120                 125             


Ala Tyr Pro Lys Ala Ala Pro Asn Asp Pro Ser Tyr Arg Gln Gln Trp 
    130                 135                 140                 


His Tyr Phe Ser Asn Tyr Gly Val Lys Ala Asp Lys Val Trp Asp Arg 
145                 150                 155                 160 


Gly Phe Thr Gly Gln Gly Val Val Val Ser Val Val Asp Thr Gly Ile 
                165                 170                 175     


Leu Asp His Val Asp Leu Asn Gly Asn Met Leu Pro Gly Tyr Asp Phe 
            180                 185                 190         


Ile Ser Ser Ala Pro Lys Ala Arg Asp Gly Asp Gln Arg Asp Asn Asn 
        195                 200                 205             


Pro Ala Asp Glu Gly Asp Trp Phe Asp Asn Trp Asp Cys Gly Gly Tyr 
    210                 215                 220                 


Pro Asp Pro Arg Arg Glu Lys Arg Phe Ser Thr Trp His Gly Ser His 
225                 230                 235                 240 


Val Ala Gly Thr Ile Ala Ala Val Thr Asn Asn Gly Val Gly Val Ala 
                245                 250                 255     


Gly Val Ala Tyr Gly Ala Lys Val Ile Pro Val Arg Val Leu Gly Lys 
            260                 265                 270         


Cys Gly Gly Tyr Asp Ser Asp Ile Thr Asp Gly Met Tyr Trp Ser Ala 
        275                 280                 285             


Gly Gly His Ile Asp Gly Val Pro Asp Asn Gln Asn Pro Ala Gln Val 
    290                 295                 300                 


Ile Asn Met Ser Leu Gly Gly Asp Gly Asp Cys Ser Gln Ser Ser Gln 
305                 310                 315                 320 


Arg Ile Ile Asp Lys Thr Thr Asn Leu Gly Ala Leu Ile Val Ile Ala 
                325                 330                 335     


Ala Gly Asn Glu Asn Gln Asp Ala Ser Arg Thr Trp Pro Ser Ser Cys 
            340                 345                 350         


Asn Asn Val Leu Ser Val Gly Ala Thr Thr Pro Lys Gly Lys Arg Ala 
        355                 360                 365             


Pro Phe Ser Asn Tyr Gly Ala Arg Val His Leu Ala Ala Pro Gly Thr 
    370                 375                 380                 


Asn Ile Leu Ser Thr Ile Asp Val Gly Gln Ala Gly Pro Val Arg Ser 
385                 390                 395                 400 


Ser Tyr Gly Met Lys Ala Gly Thr Ser Met Ala Ala Pro His Val Ser 
                405                 410                 415     


Gly Val Ala Ala Leu Val Ile Ser Ala Ala Asn Ser Ile Gly Lys Thr 
            420                 425                 430         


Leu Thr Pro Ser Glu Leu Ser Asp Ile Leu Val Arg Thr Thr Ser Arg 
        435                 440                 445             


Phe Asn Gly Arg Leu Asp Arg Gly Leu Gly Ser Gly Ile Val Asp Ala 
    450                 455                 460                 


Asn Ala Ala Val Asn Ala Val Leu Gly Asp Gln Asn Arg Ala Gln Pro 
465                 470                 475                 480 


Arg Pro Pro Val Asn Gln Pro Ile Asn Ser Gly Asn Lys Val Tyr Arg 
                485                 490                 495     


Ser Asp Arg Arg Val Ala Ile Arg Asp Leu Arg Ser Val Thr Ser Gly 
            500                 505                 510         


Ile Arg Val Asn Asp Gln Ala Arg Val Gly Ser Ala Asn Ile Thr Leu 
        515                 520                 525             


Thr Leu Asp Ile Arg His Gly Asp Arg Ser Gln Leu Ala Val Glu Leu 
    530                 535                 540                 


Ile Ala Pro Ser Gly Arg Val Tyr Pro Ile Tyr His Asp Gly Lys Arg 
545                 550                 555                 560 


Gln Pro Asn Ile Val Gly Pro Ala Thr Phe Ser Val Lys Asn Glu Arg 
                565                 570                 575     


Leu Gln Gly Thr Trp Thr Leu Lys Val Thr Asp Lys Ala Arg Gly Val 
            580                 585                 590         


Thr Gly Ser Ile Asp Ser Trp Ser Leu Thr Phe 
        595                 600             


<210>  12
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bpr mature protein (BprM), D. nodosus


<220>
<221>  PEPTIDE
<222>  (1)..(335)

<400>  12

Ala Ala Pro Asn Asp Pro Ser Tyr Arg Gln Gln Trp His Tyr Phe Ser 
1               5                   10                  15      


Asn Tyr Gly Val Lys Ala Asp Lys Val Trp Asp Arg Gly Phe Thr Gly 
            20                  25                  30          


Gln Gly Val Val Val Ser Val Val Ala Thr Gly Ile Leu Asp His Val 
        35                  40                  45              


Asp Leu Asn Gly Asn Met Leu Pro Gly Tyr Asp Phe Ile Ser Ser Ala 
    50                  55                  60                  


Pro Lys Ala Arg Asp Gly Asp Gln Arg Asp Asn Asn Pro Ala Asp Glu 
65                  70                  75                  80  


Gly Asp Trp Phe Asp Asn Trp Asp Cys Gly Gly Tyr Pro Asp Pro Arg 
                85                  90                  95      


Arg Glu Lys Arg Phe Ser Thr Trp Ala Gly Ser His Val Ala Gly Thr 
            100                 105                 110         


Ile Ala Ala Val Thr Asn Asn Gly Val Gly Val Ala Gly Val Ala Tyr 
        115                 120                 125             


Gly Ala Lys Val Ile Pro Val Arg Val Leu Gly Lys Cys Gly Gly Tyr 
    130                 135                 140                 


Asp Ser Asp Ile Thr Asp Gly Met Tyr Trp Ser Ala Gly Gly His Ile 
145                 150                 155                 160 


Asp Gly Val Pro Asp Asn Gln Asn Pro Ala Gln Val Ile Asn Met Ser 
                165                 170                 175     


Leu Gly Gly Asp Gly Asp Cys Ser Gln Ser Ser Gln Arg Ile Ile Asp 
            180                 185                 190         


Lys Thr Thr Asn Leu Gly Ala Leu Ile Val Ile Ala Ala Gly Asn Glu 
        195                 200                 205             


Asn Gln Asp Ala Ser Arg Thr Trp Pro Ser Ser Cys Asn Asn Val Leu 
    210                 215                 220                 


Ser Val Gly Ala Thr Thr Pro Lys Gly Lys Arg Ala Pro Phe Ser Asn 
225                 230                 235                 240 


Tyr Gly Ala Arg Val His Leu Ala Ala Pro Gly Thr Asn Ile Leu Ser 
                245                 250                 255     


Thr Ile Asp Val Gly Gln Ala Gly Pro Val Arg Ser Ser Tyr Gly Met 
            260                 265                 270         


Lys Ala Gly Thr Ala Met Ala Ala Pro His Val Ser Gly Val Ala Ala 
        275                 280                 285             


Leu Val Ile Ser Ala Ala Asn Ser Ile Gly Lys Thr Leu Thr Pro Ser 
    290                 295                 300                 


Glu Leu Ser Asp Ile Leu Val Arg Thr Thr Ser Arg Phe Asn Gly Arg 
305                 310                 315                 320 


Leu Asp Arg Gly Leu Gly Ser Gly Ile Val Asp Ala Asn Ala Ala 
                325                 330                 335 


<210>  13
<211>  595
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Apr5, D. nodosus


<220>
<221>  PEPTIDE
<222>  (1)..(595)

<400>  13

Met Lys Gln Ser Gly Ile Asn Gly Val Lys Thr Leu Thr Leu Val Val 
1               5                   10                  15      


Cys Ala Ala Leu Ala Ser Gln Ala Tyr Ala Ala Val Asn Tyr Glu Ser 
            20                  25                  30          


Ala Asn Tyr Ile Gly Ser Gln Pro Glu Gly Ser Val Arg Phe Ile Ile 
        35                  40                  45              


Lys Tyr Lys Asp Lys Ser Gln Ser Gln Gln Met Met Thr Asn Arg Ser 
    50                  55                  60                  


Thr Thr Ser Val Met Asn Asn Asn Asn Ile Thr Ile Ala Gly Phe Asn 
65                  70                  75                  80  


Ala Gln Phe Val Arg Thr Met Thr Ile Gly Ala Gly Ile Phe Ala Val 
                85                  90                  95      


Pro Asp Leu Lys Thr Thr Lys Glu Ala His Leu Val Met Asp Thr Ile 
            100                 105                 110         


Ala Ser Asn Pro Asp Val Glu Tyr Val Glu Val Asp Arg Trp Leu Arg 
        115                 120                 125             


Pro Phe Ala Ala Pro Asn Asp Pro Phe Tyr Asn Asp Gln Trp His Tyr 
    130                 135                 140                 


Tyr Ser Glu Tyr Gly Val Lys Ala Asp Lys Val Trp Asp Arg Gly Ile 
145                 150                 155                 160 


Thr Gly Lys Gly Val Thr Val Ala Val Val Asp Thr Gly Ile Val Asn 
                165                 170                 175     


His Pro Asp Leu Asn Ala Asn Val Ile Pro Gly Ser Gly Tyr Asp Phe 
            180                 185                 190         


Ile Gln Glu Ala Glu Ile Ala Gln Asp Gly Asp Gly Arg Asp Ser Asn 
        195                 200                 205             


Pro Ala Asp Ala Gly Asp Trp His Ser Asn Trp Ala Cys Gly Lys Tyr 
    210                 215                 220                 


Pro Asp Pro Arg Tyr Glu Lys Arg Asn Ser Ser Trp His Gly Ser His 
225                 230                 235                 240 


Val Ala Gly Thr Ile Ala Ala Val Thr Asn Asn Arg Ile Gly Val Ser 
                245                 250                 255     


Gly Val Ala Tyr Asp Ala Lys Ile Val Pro Val Arg Val Leu Gly Arg 
            260                 265                 270         


Cys Gly Gly Tyr Asn Ser Asp Ile Asn Glu Gly Met Tyr Trp Ala Ala 
        275                 280                 285             


Gly Gly His Ile Asp Gly Val Pro Asp Asn Lys His Pro Ala Gln Val 
    290                 295                 300                 


Ile Asn Met Ser Leu Gly Gly Pro Gly Val Cys Gly Ser Thr Glu Gln 
305                 310                 315                 320 


Thr Leu Ile Asn Arg Ala Thr Gln Leu Gly Ala Thr Ile Ile Val Ala 
                325                 330                 335     


Ala Gly Asn Asp Asn Ile Asp Ala Tyr Gly Val Thr Pro Ala Ser Cys 
            340                 345                 350         


Asp Asn Ile Leu Thr Val Gly Ala Thr Thr Ser Asn Gly Thr Arg Ala 
        355                 360                 365             


Tyr Phe Ser Asn His Gly Ser Val Val Asp Ile Ser Ala Pro Gly Ala 
    370                 375                 380                 


Gly Ile Thr Ser Thr Val Asp Ser Gly Ala Arg Tyr Pro Ser Gly Pro 
385                 390                 395                 400 


Ser Tyr Ser Leu Met Asp Gly Thr Ser Met Ala Thr Pro His Val Ala 
                405                 410                 415     


Gly Val Ala Ala Leu Val Ile Ser Ala Ala Asn Ser Val Asn Lys Glu 
            420                 425                 430         


Met Thr Pro Ala Gln Val Arg Asp Val Leu Val Arg Thr Val Ser Ser 
        435                 440                 445             


Phe Asn Gly Thr Pro Asp Arg Arg Ile Gly Ala Gly Ile Val Asp Ala 
    450                 455                 460                 


Asp Ala Ala Val Asn Ala Val Leu Asp Gly Asn Val Val Glu Arg Pro 
465                 470                 475                 480 


Ile Asp Glu Leu Lys Pro Gln Ala Glu Tyr Arg Asn Pro Gln Ile Lys 
                485                 490                 495     


Leu Ile Arg Asp Tyr Gln Met Met Phe Ser Glu Ile Lys Val Asn Gly 
            500                 505                 510         


Arg Pro Gly Asn Thr Lys Phe Ala Val Val Lys Ala Asp Ile Arg His 
        515                 520                 525             


Thr Asp Pro Ser Gln Leu Lys Leu Arg Leu Val Ser Pro Lys Gly Tyr 
    530                 535                 540                 


Glu Tyr Ala Val His Tyr Asp Asn Ile Lys Asn Lys Ser Ser Glu Leu 
545                 550                 555                 560 


Ile Thr Phe Pro Arg Asp Glu Gln Met Asn Gly Tyr Trp Arg Leu Lys 
                565                 570                 575     


Ile Val Asp Thr Lys Arg Gly Val Thr Gly Tyr Thr Arg Gly Trp Ser 
            580                 585                 590         


Val Ala Phe 
        595 


<210>  14
<211>  337
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Apr5 mature protein (Apr5M), D. nodosus


<220>
<221>  PEPTIDE
<222>  (1)..(337)

<400>  14

Ala Ala Pro Asn Asp Pro Phe Tyr Asn Asp Gln Trp His Tyr Tyr Ser 
1               5                   10                  15      


Glu Tyr Gly Val Lys Ala Asp Lys Val Trp Asp Arg Gly Ile Thr Gly 
            20                  25                  30          


Lys Gly Val Thr Val Ala Val Val Ala Thr Gly Ile Val Asn His Pro 
        35                  40                  45              


Asp Leu Asn Ala Asn Val Ile Pro Gly Ser Gly Tyr Asp Phe Ile Gln 
    50                  55                  60                  


Glu Ala Glu Ile Ala Gln Asp Gly Asp Gly Arg Asp Ser Asn Pro Ala 
65                  70                  75                  80  


Asp Ala Gly Asp Trp His Ser Asn Trp Ala Cys Gly Lys Tyr Pro Asp 
                85                  90                  95      


Pro Arg Tyr Glu Lys Arg Asn Ser Ser Trp Ala Gly Ser His Val Ala 
            100                 105                 110         


Gly Thr Ile Ala Ala Val Thr Asn Asn Arg Ile Gly Val Ser Gly Val 
        115                 120                 125             


Ala Tyr Asp Ala Lys Ile Val Pro Val Arg Val Leu Gly Arg Cys Gly 
    130                 135                 140                 


Gly Tyr Asn Ser Asp Ile Asn Glu Gly Met Tyr Trp Ala Ala Gly Gly 
145                 150                 155                 160 


His Ile Asp Gly Val Pro Asp Asn Lys His Pro Ala Gln Val Ile Asn 
                165                 170                 175     


Met Ser Leu Gly Gly Pro Gly Val Cys Gly Ser Thr Glu Gln Thr Leu 
            180                 185                 190         


Ile Asn Arg Ala Thr Gln Leu Gly Ala Thr Ile Ile Val Ala Ala Gly 
        195                 200                 205             


Asn Asp Asn Ile Asp Ala Tyr Gly Val Thr Pro Ala Ser Cys Asp Asn 
    210                 215                 220                 


Ile Leu Thr Val Gly Ala Thr Thr Ser Asn Gly Thr Arg Ala Tyr Phe 
225                 230                 235                 240 


Ser Asn His Gly Ser Val Val Asp Ile Ser Ala Pro Gly Ala Gly Ile 
                245                 250                 255     


Thr Ser Thr Val Asp Ser Gly Ala Arg Tyr Pro Ser Gly Pro Ser Tyr 
            260                 265                 270         


Ser Leu Met Asp Gly Thr Ala Met Ala Thr Pro His Val Ala Gly Val 
        275                 280                 285             


Ala Ala Leu Val Ile Ser Ala Ala Asn Ser Val Asn Lys Glu Met Thr 
    290                 295                 300                 


Pro Ala Gln Val Arg Asp Val Leu Val Arg Thr Val Ser Ser Phe Asn 
305                 310                 315                 320 


Gly Thr Pro Asp Arg Arg Ile Gly Ala Gly Ile Val Asp Ala Asp Ala 
                325                 330                 335     


Ala 
    


<210>  15
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Major Outer Sheath Protein (MSP), T. phagedenis


<220>
<221>  PEPTIDE
<222>  (1)..(573)

<400>  15

Met Lys Lys Tyr Leu Ile Ala Phe Ser Ile Phe Ala Phe Ala Leu Gly 
1               5                   10                  15      


Ile Ala Phe Ala Gln Glu Ala Glu Ala Ala Glu Pro Ala Gln Lys Ala 
            20                  25                  30          


Ala Ala Ala Glu Pro Ala Gln Lys Ala Ala Ala Ala Glu Pro Ala Lys 
        35                  40                  45              


Glu Pro Glu Val Tyr Ala Leu Thr Ser Gly Ala Lys Ala Ser Ile Glu 
    50                  55                  60                  


Gly Ser Thr Lys Leu Glu Trp Gly Ile Asp Leu Gly Ala Gly Lys Val 
65                  70                  75                  80  


Thr Lys Asp Ser Ile Ala His Gly Phe Lys Asn Ser Gly Ser Trp Lys 
                85                  90                  95      


Val Ser Phe Pro Leu Phe Glu Lys Lys Ser Phe Thr Ser Lys Ala Asp 
            100                 105                 110         


Thr Pro Val Tyr Ala Glu Val Ile Ile Lys Asp Val Glu Leu Gly Ile 
        115                 120                 125             


Gln Ser Lys Asn Lys Ser Lys Lys Glu Lys Asp Phe Ala Phe Thr Gly 
    130                 135                 140                 


Lys Val Asp Glu Ile Val Gly Thr Leu Tyr Phe Tyr Asp Ala Tyr Leu 
145                 150                 155                 160 


Lys Ile Tyr Lys Lys Pro Gly Phe Lys Val Asn Tyr Ala Gln Ile Trp 
                165                 170                 175     


Asp Pro Leu Lys Ala Asp Asp Trp Asp Lys Ser Gly Tyr Lys Phe Glu 
            180                 185                 190         


Pro Gly Phe Asp Ile Ala Gly Gly Thr Thr Leu Gly Tyr Lys Lys Asp 
        195                 200                 205             


Asn Ile Gly Asn Ser Gly Leu Asp Leu Asp Ala Gly Val Lys Phe Gly 
    210                 215                 220                 


Ser Asn Gly Asn Trp Glu Thr Glu Gly Lys Ser Asp Tyr Glu Gly Ser 
225                 230                 235                 240 


Pro Gln Tyr Ala Leu Ile Thr Gly Pro Ala Thr Leu Ala Lys Gly Ser 
                245                 250                 255     


Thr Tyr Val Glu Leu Glu Pro Val Tyr Gly Lys Glu Ala Glu Glu Lys 
            260                 265                 270         


Ala Ser Tyr Ile Met Leu Asp Asn Gln Arg Phe Lys Ile Thr Ser Asn 
        275                 280                 285             


Phe Lys Lys Val Ser Pro Asp Lys Asp Leu Glu Val Lys Glu Gly Lys 
    290                 295                 300                 


Tyr Tyr Ala Lys Ile Asp Gly Leu Thr Lys Lys Asp Thr Pro Ala Thr 
305                 310                 315                 320 


Lys Asn Arg Tyr Gly Met Gly Phe Tyr Thr Ser Val Ala Tyr Lys Pro 
                325                 330                 335     


Gly Asp Leu Lys Tyr Ile Gly Phe Asn Phe Asp Ile Asn Thr Thr Phe 
            340                 345                 350         


Cys Ser His Lys Asp Trp Glu Asn Asn Thr Glu Lys Gly Asn Tyr Phe 
        355                 360                 365             


Asn Val Ser Phe Gly Thr Lys Ile Thr Ser Glu Pro Val Lys Asp Leu 
    370                 375                 380                 


Ser Leu Val Leu Ala Phe Asp Gly Glu Pro Phe Val Asn Gly Glu Lys 
385                 390                 395                 400 


Lys Phe Ala Trp Asp Met Leu Phe Asp Thr Thr Tyr Lys Trp Val Gly 
                405                 410                 415     


Ala Gly Val Tyr Val Gly Asn Glu Asn Thr Phe Tyr Lys Ser Asn Lys 
            420                 425                 430         


Asp Lys Val Asp Met Ser Ile Tyr Ala Lys Phe Glu Thr Lys Gly Asp 
        435                 440                 445             


Lys Lys Lys Ala Asn Phe Leu Val Glu Asn Leu Asn Ala Gly Ala Ala 
    450                 455                 460                 


Ile Tyr Val His His Leu Leu Ser Lys Pro Val Ser Pro Lys Thr Val 
465                 470                 475                 480 


Pro Ile Gly Leu Lys Val Tyr Ala Asp Tyr Lys Tyr Asp Ile Asn Asp 
                485                 490                 495     


Ser Met Trp Leu Lys Pro Tyr Ala Ser Phe Tyr Gly Glu Thr Asn His 
            500                 505                 510         


Ala Glu Pro Lys Phe Gly Val Tyr Tyr Asn Val Gly Leu Thr Phe Ser 
        515                 520                 525             


Pro Leu Glu Arg Leu Glu Leu Thr Ala Asp Trp Glu Gln Gly Lys Val 
    530                 535                 540                 


Val Lys Asn Lys His Glu Gly Phe Ile Glu Lys Ser Ala Gly Lys Glu 
545                 550                 555                 560 


His Asn Gly Arg Phe Lys Leu Gly Cys Lys Val Ser Phe 
                565                 570             


