                         SEQUENCE LISTING

<110>  Universite Laval
 
<120>  Use of SRSF3 agents for the treatment and/or prevention of 
       neurological conditions, cancer, bacterial infections or viral 
       infections

<130>  000819-0383

<150>  62/586,567
<151>  2017-11-15

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  5306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Flag/EGFP tagged murine Rpl10a construction under control of the 
       CD11b promoter, I: Intervening sequence (IVS); II: SV40 polyA

<400>  1
gggccctcca gggttcaagt gattctgctg cctcagcctc ccaggtggga ttacaggtgc       60

ctgccaccac gcctggctaa tttttttgtc tttttagtaa agatgaggtt tcaccatgtt      120

gggcaggctg gtttcaattg ctgacctcaa gtgagccacc ccgcctcagc ctcccaaaat      180

gctaggatta caggcatgag ccaccgcacc cagccaagtt tgtacatata tttttgacta      240

cacttcttaa ctattcttag gataaattac tagaagtgaa aattcttggg tgaagagctt      300

gaggccttta cacacacaca cacacacaca cacaaaaata ggctggatgc agtggctcac      360

acctgtaatc tcagcagttt gggaggctga ggaaggagga tcacttgagt ccaggaggtt      420

gagaatagcc tgaacaacat agcaagatct tgtctctaca aaaaatttaa aaaaaattag      480

ctggccatgg cagcatgtgc ctgtagtacc agctactcgg aaggctgagg taggaggatc      540

gcttgagccc aggaggttga ttgaagctgc agtgagctgt gattacacca ctgcactcca      600

gcctgggcaa cagagctaga ctctgtctct aaaaaaagca caaaataata tttaaaaagc      660

accaggtatg cctgtacttg agttgtcttt gttgatggct acaaatgagg acagctctgg      720

ctgaagggcg cttccatttc catgggctga aggagggaca ttttgcaaag tgtgttttca      780

ggaagacaca gagttttacc tcctacactt gtttgatctg tattaatgtt tgcttattta      840

tttatttaat tttttttttg agacagagtc tcactctgtc acctgggctg gagtgcagtg      900

gcattattga ggctcattgc agtctcagac tcctgagctc aaacaatcct cctgcctcag      960

cctctggagt agctaggact acaggcatgt gccaccatgc ctggctaatt ttttaaatgt     1020

atttttttgt agagtcgggg tctccctatg ttgcccaggc tggagtgcag tggtgtgatc     1080

ctagctcact gcagcctgga cctcgggctc aagtaattct cacacctcag cctgtccagt     1140

agcaggggct acaggcgcgc accaccatgc ccagctaatt aaaaatattt ttttgtagag     1200

acagggtctc tctatgttgc ccaggctggt ttcaaactcc caggctcaag caatcctcct     1260

gccttggcct cccaaagtgc tggcattaca ggcgtgagcc actgcgcctg gcccgtatta     1320

atgtttagaa cacgaattcc aggaggcagg ctaagtctgt tcagcttgtt catatgcttg     1380

ggccaaccca agaaacaagt gggtgacaaa tggcaccttt tggatagtgg tattgacttt     1440

gaaagtttgg gtcaggaagc tggggaggaa gggtgggcag gctgtgggca gtcctgggcg     1500

gaagaccagg cagggctatg tgctcactga gcctccgccc tcttcctttg aatctctgat     1560

agacttctgc ctcctacttc tccttttctg cccttctttg ctttggtggc ttccttgtgg     1620

ttcctcagtg gtgcctgcaa cccctggttc acctccttcc aggttctggc tccttccagc     1680

cgtcgacggt atcgataagc ttgatatcta agtatcaagg ttacaagaca ggtttaagga     1740

gaccaataga aactgggctt gtcgagacag agaagactct tgcgtttctg ataggcacct     1800

attggtctta ctgacatcca ctttctttct ctccacagga attccctgca ggaggcagca     1860

tggactacaa agacgacgac gacaaggtga gcaagggcga ggagctgttc accggggtgg     1920

tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc gtgtccggcg     1980

agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc accaccggca     2040

agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg cagtgcttca     2100

gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg cccgaaggct     2160

acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc cgcgccgagg     2220

tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc gacttcaagg     2280

aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac aacgtctata     2340

tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc cacaacatcg     2400

aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc ggcgacggcc     2460

ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc aaagacccca     2520

acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg atcactctcg     2580

gcatggacga gctgtacaag taaggatccc ggccgcaaac tgcagcgcct ctccggcttg     2640

gctgagcgcg gaacgtgccc gtaacgggca actctcgcga gaacgcgggc tctatttgag     2700

cgcatgcgca aagcgctctg ccttctttcc ggtttccgcg gcagccgcag ccatgaggta     2760

agttgttatc gtggcgctat ccgccgccat ccgtgcaccc acacgcccgc ggacgccccg     2820

cggcccgtct cggaggctct cccggcgact gccccgcgtc gcgagccttt ccccagcgtg     2880

ccgtgggcct gtcatcgggc ccggggtgca gcatggccgg ccccgaacgc cttcgcttct     2940

ccccaacagc agcaaagtct cacgcgacac cctgtacgag gcggtgcggg aagtcctgca     3000

cgggaaccag cgcaagcgcc gcaagtgagc gcgggcctcc ctcccggggc agggcgagca     3060

tccccggcca tggcgaccct ggctcacagc tcccctctcg ctcaggtttc tggagacggt     3120

ggagctgcag atcagcctga agaactacga ccctcagaag gacaaacgtt tctcgggcac     3180

cgtcaggttg gcaccgctct aaccccaccc agccctcagt gttcccgtgt ggcctggccg     3240

cgccctaggc gggcacgggg acactgacgt gccagggtag ttcaggagcc ctgctgcagg     3300

caggcaggct ggacggaccc ccaccctggg tcttaaaaca agaggggagg cgtggggagg     3360

cctcggccga gcccgccgcc tagcctgaga agccaggcta gtgttgccca gagctccggg     3420

taaggcttgc cgctccctgc catgcgttca gatctagcgg gatggccagc gccgaccatg     3480

acctgttctg ttttctcccc tcccaaacgc aggctcaagt ccaccccacg ccccaagttc     3540

tcggtgtgcg ttctggggga ccagcagcac tgtgatgaag ccaaggccgt ggatatcccc     3600

cacatggaca tcgaggcgct caagaagctt aacaaaaaca agaagttggt caagaagctg     3660

ggtaggtggg gctcactagg gctgaacaca acccatgacc ccctgcccag gagtggcagc     3720

acacattggg cttcacaacc agttagaaaa tgccccacag gctggtctga tactcccctc     3780

tcgccagtgt gtgcagttga ctcatagcca gctattggtt tgggtttcaa gtcttttcag     3840

ttaacaacct atcgagggag gggtcacaag tgtctcccac gtgttagcct ccatggtagc     3900

ccctgtctcc gcatacattt tgggaatagt tatccactgt gagctaggca gttgtcatgc     3960

ctgcttttat agatagaagg tttctccatc tgtcttaaga tttggagtaa tactgagtct     4020

tactgatgtt gccagcctgg ggtctaaggt tatcctctag aagtgctcag gactgtgccc     4080

tgtcactgag ctgtgttctc aggtgacatt atggttccca ggcctgcttg aggcttctca     4140

gatagctggc cttggtccac ctttgacaga taatgagaca gcttttttct taagatttta     4200

ttttatgtat atgagcaggc tgatgagagc ctcagatccc attacaggtg gctgtgagcc     4260

accatgtggc tgctggaaat tgaactcagg acctctggaa ggcagcactc ttaactgctg     4320

agccatctct ccagtccata gtttgaggca atttaaatgc aggcttacag tgaatccaag     4380

gggtgggggc catcacagcc cctcagttct atgcagcaca ccagggattg tgggacatcc     4440

tggtctaaga cctctgtgag gacttgaggg tggagctact cagcagtcat gggtctgagg     4500

aggcaacttg gccttctcgt tgtaaaggat gggttggttg tttaaaatgt tttgttttgt     4560

tttttttttt ttttggtggt ttttgtttgt ttggttggtt tttttggttt ttttggtttt     4620

tttttttttt tttggctcaa tcctgagtgt ctgtgtcttc tagctaagaa gtacgatgcc     4680

tttttggcct ctgagtctct gattaagcag atcccacgta tcctgggccc aggcctaaac     4740

aaggctggca agttcccctc cctgctgaca cacaatgaaa acatggtggc caaagtggat     4800

gaggtgaaat cgacaatcaa gttccagatg aagaaggtca gtctgggcgg tgtgtggtgg     4860

ggaaaccaga aagagctagg tctgggtgcc ttagccctgg gttaagcctt ttcactgggg     4920

gaaagggtac atgctagctt agcctggtga ccttttctgt ccatgcaggt gctgtgtttg     4980

gccgtcgctg ttggccacgt gaagatgacc gatgatgagc tagtctacaa cattcatctg     5040

gctgtcaatt tcttggtgtc cttgcttaag aaaaactggc aaaacgtgcg ggctctgtac     5100

atcaagagca ccatgggcaa gccccagcgt ctgtattagg atgctccaat aaacctcact     5160

gctgccactc aggcggccgc accgcggttg atgagtttgg acaaaccaca actagaatgc     5220

agtgaaaaaa atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta     5280

taagctgcaa taaacaagtt ccgcgg                                          5306


<210>  2
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGL3-promoter- Saa3-3'UTR-wt

<400>  2
gttttctctt cctgttgttc ccagtcatgc tgccccccga gaagaggagc aactactggg       60

ttgagatatt ttctaaaatc tggatc                                            86


<210>  3
<211>  168
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGL3-promoter-SCRAMBLE

<400>  3
ggatatcttt tacccatacg atgttcctga ctatgcgggc tatccctatg acgtcccgga       60

ctatgcagga tcctatccat atgacgttcc agattacgct gctcagatcg ataagcttac      120

catgttccag gcggccgagc gcccccagga gtgggccatg gagggccc                   168


<210>  4
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Saa3-3'UTR deletion of segment C

<400>  4
gttttctctt cctgttgttc ccagtcatgc tgccccccga gaagaggagc aactactggg       60

ttgagatatt ttctaaaatc tggatcc                                           87


<210>  5
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Saa3-3'UTR deletion of segment B+C

<400>  5
gttttctctt cctgttgttc ccagtcatgc tgccccccgt ctaga                       45


<210>  6
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Saa3-3'UTR deletion of segment A

<400>  6
agaagaggag caactactgg gttgagatat tttctaaaat ctggatccct aaacatccca       60

atgtgctgaa taaatacttg tgaaatgca                                         89


<210>  7
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Saa3-3'UTR deletion of segment B

<400>  7
gttttctctt cctgttgttc ccagtcatgc tgccccccga atgtgctgaa taaatacttg       60

tgaaatgca                                                               69


<210>  8
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeting SRSF3 - ON-TARGETplus SMARTpool siRNA 
       J-059214-09, Srsf3

<400>  8
gaaaggcacc ugagaauau                                                    19


<210>  9
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeting SRSF3 - ON-TARGETplus SMARTpool siRNA 
       J-059214-10, Srsf3

<400>  9
ccagaugaga uuuagguau                                                    19


<210>  10
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeting SRSF3 - ON-TARGETplus SMARTpool siRNA 
       J-059214-11, Srsf3

<400>  10
cuagcauaau uguguagua                                                    19


<210>  11
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA targeting SRSF3 - ON-TARGETplus SMARTpool siRNA 
       J-059214-12, Srsf3

<400>  11
cuagaagguu ccaacauga                                                    19


<210>  12
<211>  164
<212>  PRT
<213>  Mus musculus

<400>  12

Met His Arg Asp Ser Cys Pro Leu Asp Cys Lys Val Tyr Val Gly Asn 
1               5                   10                  15      


Leu Gly Asn Asn Gly Asn Lys Thr Glu Leu Glu Arg Ala Phe Gly Tyr 
            20                  25                  30          


Tyr Gly Pro Leu Arg Ser Val Trp Val Ala Arg Asn Pro Pro Gly Phe 
        35                  40                  45              


Ala Phe Val Glu Phe Glu Asp Pro Arg Asp Ala Ala Asp Ala Val Arg 
    50                  55                  60                  


Glu Leu Asp Gly Arg Thr Leu Cys Gly Cys Arg Val Arg Val Glu Leu 
65                  70                  75                  80  


Ser Asn Gly Glu Lys Arg Ser Arg Asn Arg Gly Pro Pro Pro Ser Trp 
                85                  90                  95      


Gly Arg Arg Pro Arg Asp Asp Tyr Arg Arg Arg Ser Pro Pro Pro Arg 
            100                 105                 110         


Arg Arg Ser Pro Arg Arg Arg Ser Phe Ser Arg Ser Arg Ser Arg Ser 
        115                 120                 125             


Leu Ser Arg Asp Arg Arg Arg Glu Arg Ser Leu Ser Arg Glu Arg Asn 
    130                 135                 140                 


His Lys Pro Ser Arg Ser Phe Ser Arg Ser Arg Ser Arg Ser Arg Ser 
145                 150                 155                 160 


Asn Glu Arg Lys 
                


<210>  13
<211>  73
<212>  PRT
<213>  Mus musculus

<400>  13

Lys Val Tyr Val Gly Asn Leu Gly Asn Asn Gly Asn Lys Thr Glu Leu 
1               5                   10                  15      


Glu Arg Ala Phe Gly Tyr Tyr Gly Pro Leu Arg Ser Val Trp Val Ala 
            20                  25                  30          


Arg Asn Pro Pro Gly Phe Ala Phe Val Glu Phe Glu Asp Pro Arg Asp 
        35                  40                  45              


Ala Ala Asp Ala Val Arg Glu Leu Asp Gly Arg Thr Leu Cys Gly Cys 
    50                  55                  60                  


Arg Val Arg Val Glu Leu Ser Asn Gly 
65                  70              


<210>  14
<211>  79
<212>  PRT
<213>  Mus musculus

<400>  14

Arg Ser Arg Asn Arg Gly Pro Pro Pro Ser Trp Gly Arg Arg Pro Arg 
1               5                   10                  15      


Asp Asp Tyr Arg Arg Arg Ser Pro Pro Pro Arg Arg Arg Ser Pro Arg 
            20                  25                  30          


Arg Arg Ser Phe Ser Arg Ser Arg Ser Arg Ser Leu Ser Arg Asp Arg 
        35                  40                  45              


Arg Arg Glu Arg Ser Leu Ser Arg Glu Arg Asn His Lys Pro Ser Arg 
    50                  55                  60                  


Ser Phe Ser Arg Ser Arg Ser Arg Ser Arg Ser Asn Glu Arg Lys 
65                  70                  75                  


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense

<400>  15
ccaagggaca ggaatcacga tgcat                                             25


<210>  16
<211>  84
<212>  DNA
<213>  Mus musculus

<400>  16
ggtgggcctg tcggagcgtt aggatttgag cttgggcctt ttgaacccag gatctcgaaa       60

tgcatcgtga ttcctgtccc ttgg                                              84


<210>  17
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense

<400>  17
ccaatggaca ggaatcacga tgcat                                             25


<210>  18
<211>  56
<212>  DNA
<213>  Homo sapiens

<400>  18
gccgccgcat tttttaaccc tagatctcga aatgcatcgt gattcctgtc cattgg           56


<210>  19
<211>  720
<212>  DNA
<213>  Homo sapiens

<400>  19
tttccaggtc acctgaccgg tctcctttgc tgtcggcgcc aagtcctgca agtttgcttg       60

agagacgaga aaccagcaag agttgggcaa actttccaaa ccaggctttt ccttcagtgt      120

ggaatctagg cggccacagt ctggtgccag ctgggtcaca aacagctccg tgacctgttt      180

gtaaacgcga tgctcttagt tccagactaa ccgctcacaa gggtgaagca cttaattaat      240

tcatctctta atcttgttag gggccaacgg ctcctattag tgtttgagcg tgacggcgac      300

ggtgctgttt atgaagccct agcctatttg gaggtgagga agaggagtct gtgggtaacc      360

tggaggtcga cagaccggga ggaacgctcg agggagcacc aggcctgtta caacgagcgc      420

gcgccgacgc acgtctccac ccacccggcg caaccgccag agcgcgctcc cagcaaccgc      480

ggctctcgct gcgtttgtag ccatacgtca cggcctcttc tgcttctcat tgggggagcc      540

cgtccaatca tgtgattcca gtatggcgta taaataaagg cgaggagaag gcggtggtcc      600

gccatttcgt ggacgccggg tgagtgagag agttggttgg tgttgggccg gaggaaagcg      660

ggaagactca tcggagcgtg tggatttgag ccgccgcatt ttttaaccct agatctcgaa      720


<210>  20
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fragment

<400>  20

Gly Asn Asn Gly Asn Lys Thr Glu Leu Glu Arg Ala Phe Gly Tyr Tyr 
1               5                   10                  15      


Gly Pro Leu Arg Ser Val 
            20          


