                               SEQUENCE LISTING

<110> SANGAMO THERAPEUTICS, INC.
 
<120> GENETIC MODIFICATION OF CYTOKINE INDUCIBLE SH2-CONTAINING PROTEIN
      (CISH) GENE

<130> 8325-0167.40

<140> PCT/US2018/060038
<141> 2018-11-09

<150> 62/716,002
<151> 2018-08-08

<150> 62/583,724
<151> 2017-11-09

<160> 50    

<170> PatentIn version 3.5

<210> 1
<211> 196
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      FokI cleavage half domain sequence

<400> 1
Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
1               5                   10                  15      


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            20                  25                  30          


Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        35                  40                  45              


Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 
    50                  55                  60                  


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
65                  70                  75                  80  


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                85                  90                  95      


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg 
            100                 105                 110         


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        115                 120                 125             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    130                 135                 140                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
145                 150                 155                 160 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                165                 170                 175     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            180                 185                 190         


Glu Ile Asn Phe 
        195     


<210> 2
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Arg Ser Asp His Leu Ser Gln 
1               5           


<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gln Asn Ala Thr Arg Thr Lys 
1               5           


<210> 4
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Arg Ser Asp Asn Leu Ser Glu 
1               5           


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Lys Arg Cys Asn Leu Arg Cys 
1               5           


<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Asp Arg Ser Thr Arg Thr Lys 
1               5           


<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Arg Arg Asp Asn Leu His Ser 
1               5           


<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Gly His Thr Ser Leu Lys Arg 
1               5           


<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Thr Ser Gly His Leu Ser Arg 
1               5           


<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Arg Ser Asp Asn Leu Ala Arg 
1               5           


<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Gln Asn Val Ser Arg Pro Arg 
1               5           


<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Gln Ser Gly His Leu Ser Arg 
1               5           


<210> 13
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Arg Trp Gln Tyr Leu Pro Thr 
1               5           


<210> 14
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Asp Arg Ser Ala Leu Ala Arg 
1               5           


<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Asp Arg Ser Asn Leu Thr Arg 
1               5           


<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gln Ser Gly Asn Leu Ala Arg 
1               5           


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Ala Thr Cys Cys Leu Ala His 
1               5           


<210> 18
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Arg Ser Asp Asp Leu Thr Arg 
1               5           


<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gln Ala Ala Thr Leu Ser Arg 
1               5           


<210> 20
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Arg Ser Asp His Leu Ser Ala 
1               5           


<210> 21
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Asp Arg Ser Asp Leu Ser Arg 
1               5           


<210> 22
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 22
Asp Arg Ser His Leu Ala Arg 
1               5           


<210> 23
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Gln Ser Gly Asp Leu Thr Arg 
1               5           


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Gln Ser Gly Asn Leu His Val 
1               5           


<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Gln Ser Gly His Leu Ala Arg 
1               5           


<210> 26
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Asn Arg Tyr Asp Leu Met Thr 
1               5           


<210> 27
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Arg Ser Asp Ser Leu Leu Arg 
1               5           


<210> 28
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Cys Arg Glu Tyr Arg Gly Lys 
1               5           


<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Gln Ser Ser His Leu Thr Arg 
1               5           


<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Gln Ser Ser Asp Leu Thr Arg 
1               5           


<210> 31
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Arg Leu Asp Ile Leu Gln Gln 
1               5           


<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Arg Ser Asp Asn Leu Ser Thr 
1               5           


<210> 33
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Asp Asn Ser Tyr Leu Pro Arg 
1               5           


<210> 34
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Asp Arg Ser Asn Leu Ser Arg 
1               5           


<210> 35
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Leu Arg Gln Asp Leu Lys Arg 
1               5           


<210> 36
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Asp Asn Ser Asn Arg Ile Asn 
1               5           


<210> 37
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Gln Ser Ser Asp Leu Ser Arg 
1               5           


<210> 38
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Trp Lys Trp Asn Leu Arg Ala 
1               5           


<210> 39
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Gln Lys Gly Thr Leu Gly Glu 
1               5           


<210> 40
<211> 28
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      CISH target site sequence

<400> 40
ggaaggcccc agcaggcaag ggctgcat                                          28


<210> 41
<211> 28
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      CISH target site sequence

<400> 41
gaggaggtgg cagagggtac cccagccc                                          28


<210> 42
<211> 28
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      CISH target site sequence

<400> 42
ccagcaaagg acgaggtcta gaaggcag                                          28


<210> 43
<211> 28
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      CISH target site sequence

<400> 43
gtggagcgga ctgggcagcg gcccctgt                                          28


<210> 44
<211> 28
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      CISH target site sequence

<400> 44
gatgcgtggc ctggacaagc agttggag                                          28


<210> 45
<211> 28
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      CISH target site sequence

<400> 45
gagtccagac ggaagctgga gtcggcat                                          28


<210> 46
<211> 28
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      CISH target site sequence

<400> 46
atagtgctgc acaaggctga ccacatcc                                          28


<210> 47
<211> 28
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      CISH target site sequence

<400> 47
ccggaaaggc caggatgcgt ggcctgga                                          28


<210> 48
<211> 1100
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      CISH sequence

<400> 48
atgggtcctc cactcactgc tcatccactg ccttctagac ctcgtccttt gctggctgtg       60

gagcggactg ggcagcggcc cctgtgggcc ccgtccctgg aactgcccaa gccagtcatg      120

cagcccttgc ctgctggggc cttcctcgag gaggtggcag agggtacccc agcccagaca      180

gagagtgagc caaaggtgct ggacccagag gaggatctgc tgtgcatagc caagaccttc      240

tcctaccttc gggaatctgg tgagtctgag gggggaggca ggccttttcc tgagtagtct      300

ggtgggagaa gcttagttct gcctttgagt ctgatttggg aggcatagcc cggcccagga      360

gagtctgatg ggagaggcac agccctctct agggaagcgt gaagctggag gcactgcctt      420

gacttgcact ggattggtta ccccagctaa tttccactat gtcccttggc cccctctgca      480

cttgcctagg ctggtattgg ggttccatta cggccagcga ggcccgacaa cacctgcaga      540

agatgccaga aggcacgttc ttagtacgtg acagcacgca ccccagctac ctgttcacgc      600

tgtcagtgaa aaccactcgt ggccccacca atgtacgcat tgagtatgcc gactccagct      660

tccgtctgga ctccaactgc ttgtccaggc cacgcatcct ggcctttccg gatgtggtca      720

gccttgtgca gcactatgtg gcctcctgca ctgctgatac ccgaagcgac agccccgatc      780

ctgctcccac cccggccctg cctatgccta aggaggatgc gcctagtgac ccagcactgc      840

ctgctcctcc accagccact gctgtacacc taaaactggt gcagcccttt gtacgcagaa      900

gcagtgcccg cagcctgcaa cacctgtgcc gccttgtcat caaccgtctg gtggccgacg      960

tggactgcct gccactgccc cggcgcatgg ccgactacct ccgacagtac cccttccagc     1020

tctgactgta cggggcaatc tgcccaccct cacccagtcg caccctggag gggacatcag     1080

ccccagctgg acttgggccc                                                 1100


<210> 49
<211> 9
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      'LAGLIDADG' family peptide motif sequence

<400> 49
Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210> 50
<211> 32
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      CISH sequence

<400> 50
ggaaaggcca ggatgcgtgg cctggacaag ca                                     32


