                               SEQUENCE LISTING

<110> TRUSTEES OF TUFTS COLLEGE
 
<120> HETEROMULTIMERIC BINDING MOLECULES FOR TOXIN NEUTRALIZATION, 
      COMPOSITIONS AND METHODS THEREOF

<130> 167774.011801/PCT

<140> PCT/US2018/049695
<141> 2018-09-06

<150> 62/582,596
<151> 2017-11-07

<160> 21    

<170> PatentIn version 3.5

<210> 1
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Asp Glu Leu Gly Pro Arg Leu Met Gly Lys 
1               5                   10  


<210> 2
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Gly Gly Gly Gly Asp Glu Leu Gly Pro Arg Leu Met Gly Lys Gly Gly 
1               5                   10                  15      


Gly Gly 
        


<210> 3
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu Glu Pro Arg 
1               5                   10              


<210> 4
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Gly Gly Gly Gly Ser 
1               5   


<210> 5
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 6
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser Ser Ile Gly Trp Phe Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Ile Ser Ser Ser 
        35                  40                  45              


Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Thr 
    50                  55                  60                  


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ala Phe Arg Ala Thr 
                85                  90                  95      


Met Cys Gly Val Phe Pro Leu Ser Pro Tyr Gly Lys Asp Asp Trp Gly 
            100                 105                 110         


Lys Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210> 7
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Val Met Thr Trp Val Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile Ala Thr Ile Asn Thr Asp 
        35                  40                  45              


Gly Ser Thr Met Arg Asp Asp Ser Thr Lys Gly Arg Phe Thr Ile Ser 
    50                  55                  60                  


Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Thr Ser Leu Lys 
65                  70                  75                  80  


Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Gly Arg Val Ile Ser 
                85                  90                  95      


Ala Ser Ala Ile Arg Gly Ala Val Arg Gly Pro Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 8
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Gln Gly Val Gln Ser Gln Leu Gln Leu Val Glu 
1               5                   10      


<210> 9
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Glu Pro Lys Thr Pro Lys Pro Gln Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gln Gly Val Gln Ser Gln Val Gln Leu 
            20                  25                  30          


Val Glu 
        


<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Glu Pro Lys Thr Pro Lys Pro Gln 
1               5               


<210> 11
<211> 121
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Gly Ile Gly Trp Phe Arg 
            20                  25                  30          


Gln Pro Pro Gly Lys Glu Arg Glu Ala Val Ser Tyr Ile Ser Ala Ser 
        35                  40                  45              


Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    50                  55                  60                  


Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu 
65                  70                  75                  80  


Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Arg Phe Ser 
                85                  90                  95      


Ala Ser Ser Val Asn Arg Trp Leu Ala Asp Asp Tyr Asp Val Trp Gly 
            100                 105                 110         


Arg Gly Thr Gln Val Ala Val Ser Ser 
        115                 120     


<210> 12
<211> 105
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Ser Gly Gly Gly Leu Val Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Ser Ser Gly Ser Ile Ala Gly Phe Glu Thr Val Thr Trp Ser Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Ser Leu Gln Trp Val Ala Ser Met Thr Lys Thr 
        35                  40                  45              


Asn Asn Glu Ile Tyr Ser Asp Ser Val Lys Gly Arg Phe Ile Ile Ser 
    50                  55                  60                  


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys 
65                  70                  75                  80  


Pro Glu Asp Thr Gly Val Tyr Phe Cys Lys Gly Pro Glu Leu Arg Gly 
                85                  90                  95      


Gln Gly Ile Gln Val Thr Val Ser Ser 
            100                 105 


<210> 13
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Ser Gly Gly Gly Leu Val Gln Val Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Val Val Ser Gly Ser Asp Ile Ser Gly Ile Ala Met Gly Trp Tyr Arg 
            20                  25                  30          


Gln Ala Pro Gly Lys Arg Arg Glu Met Val Ala Asp Ile Phe Ser Gly 
        35                  40                  45              


Gly Ser Thr Asp Tyr Ala Gly Ser Val Lys Gly Arg Phe Thr Ile Ser 
    50                  55                  60                  


Arg Asp Asn Ala Lys Lys Thr Ser Tyr Leu Gln Met Asn Asn Val Lys 
65                  70                  75                  80  


Pro Glu Asp Thr Gly Val Tyr Tyr Cys Arg Leu Tyr Gly Ser Gly Asp 
                85                  90                  95      


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105             


<210> 14
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Ser Gly Gly Gly Leu Val His Pro Gly Gly Ser Leu Arg Leu Ser Cys 
1               5                   10                  15      


Ala Pro Ser Ala Ser Leu Pro Ser Thr Pro Phe Asn Pro Phe Asn Asn 
            20                  25                  30          


Met Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Met Val 
        35                  40                  45              


Ala Ser Ile Gly Leu Arg Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg 
    50                  55                  60                  


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln Met 
65                  70                  75                  80  


Asp Ser Leu Arg Pro Glu Asp Ser Ala Thr Tyr Tyr Cys His Ile Glu 
                85                  90                  95      


Tyr Thr His Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110     


<210> 15
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp 
1               5                   10              


<210> 16
<211> 374
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Ser Gly Gly Gly Gly Asp Glu Leu Gly Pro Arg Leu Met Gly 
        35                  40                  45              


Lys Gly Gly Gly Gly Gln Gly Val Gln Ser Gln Leu Gln Leu Val Glu 
    50                  55                  60                  


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
65                  70                  75                  80  


Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser Ser Ile Gly Trp Phe Arg 
                85                  90                  95      


Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Ile Ser Ser Ser 
            100                 105                 110         


Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Thr 
        115                 120                 125             


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
    130                 135                 140                 


Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ala Phe Arg Ala Thr 
145                 150                 155                 160 


Met Cys Gly Val Phe Pro Leu Ser Pro Tyr Gly Lys Asp Asp Trp Gly 
                165                 170                 175     


Lys Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
            180                 185                 190         


Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Gln Gly Val Gln Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    210                 215                 220                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
225                 230                 235                 240 


Thr Phe Ser Asp Tyr Val Met Thr Trp Val Arg Gln Ala Pro Gly Lys 
                245                 250                 255     


Gly Pro Glu Trp Ile Ala Thr Ile Asn Thr Asp Gly Ser Thr Met Arg 
            260                 265                 270         


Asp Asp Ser Thr Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        275                 280                 285             


Asn Thr Leu Tyr Leu Gln Met Thr Ser Leu Lys Pro Glu Asp Thr Ala 
    290                 295                 300                 


Leu Tyr Tyr Cys Ala Arg Gly Arg Val Ile Ser Ala Ser Ala Ile Arg 
305                 310                 315                 320 


Gly Ala Val Arg Gly Pro Gly Thr Gln Val Thr Val Ser Ser Glu Pro 
                325                 330                 335     


Lys Thr Pro Lys Pro Gln Gly Gly Gly Gly Asp Glu Leu Gly Pro Arg 
            340                 345                 350         


Leu Met Gly Lys Gly Gly Gly Gly Ser Asp Ile Cys Leu Pro Arg Trp 
        355                 360                 365             


Gly Cys Leu Trp Glu Asp 
    370                 


<210> 17
<211> 364
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Ser Gly Gly Gly Gly Asp Glu Leu Gly Pro Arg Leu Met Gly 
        35                  40                  45              


Lys Gly Gly Gly Gly Gln Gly Val Gln Ser Gln Leu Gln Leu Val Glu 
    50                  55                  60                  


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
65                  70                  75                  80  


Glu Ala Ser Gly Phe Thr Leu Asp Tyr Tyr Gly Ile Gly Trp Phe Arg 
                85                  90                  95      


Gln Pro Pro Gly Lys Glu Arg Glu Ala Val Ser Tyr Ile Ser Ala Ser 
            100                 105                 110         


Ala Arg Thr Ile Leu Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        115                 120                 125             


Ser Arg Asp Asn Ala Lys Asn Ala Val Tyr Leu Gln Met Asn Ser Leu 
    130                 135                 140                 


Lys Arg Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Arg Arg Phe Ser 
145                 150                 155                 160 


Ala Ser Ser Val Asn Arg Trp Leu Ala Asp Asp Tyr Asp Val Trp Gly 
                165                 170                 175     


Arg Gly Thr Gln Val Ala Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
            180                 185                 190         


Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        195                 200                 205             


Gln Gly Val Gln Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    210                 215                 220                 


Val Gln Thr Gly Gly Ser Leu Arg Leu Ser Cys Ala Ser Ser Gly Ser 
225                 230                 235                 240 


Ile Ala Gly Phe Glu Thr Val Thr Trp Ser Arg Gln Ala Pro Gly Lys 
                245                 250                 255     


Ser Leu Gln Trp Val Ala Ser Met Thr Lys Thr Asn Asn Glu Ile Tyr 
            260                 265                 270         


Ser Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys 
        275                 280                 285             


Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Gly 
    290                 295                 300                 


Val Tyr Phe Cys Lys Gly Pro Glu Leu Arg Gly Gln Gly Ile Gln Val 
305                 310                 315                 320 


Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Gly Gly Gly Gly 
                325                 330                 335     


Asp Glu Leu Gly Pro Arg Leu Met Gly Lys Gly Gly Gly Gly Ser Asp 
            340                 345                 350         


Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp 
        355                 360                 


<210> 18
<211> 667
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Ser Gly Gly Gly Gly Asp Glu Leu Gly Pro Arg Leu Met Gly 
        35                  40                  45              


Lys Gly Gly Gly Gly Gln Gly Val Gln Ser Gln Leu Gln Leu Val Glu 
    50                  55                  60                  


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
65                  70                  75                  80  


Ala Ala Ser Gly Phe Thr Leu Asp Tyr Ser Ser Ile Gly Trp Phe Arg 
                85                  90                  95      


Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser Cys Ile Ser Ser Ser 
            100                 105                 110         


Gly Asp Ser Thr Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Thr 
        115                 120                 125             


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu 
    130                 135                 140                 


Lys Pro Asp Asp Thr Ala Val Tyr Tyr Cys Ala Ala Phe Arg Ala Thr 
145                 150                 155                 160 


Met Cys Gly Val Phe Pro Leu Ser Pro Tyr Gly Lys Asp Asp Trp Gly 
                165                 170                 175     


Lys Gly Thr Leu Val Thr Val Ser Ser Glu Pro Lys Thr Pro Lys Pro 
            180                 185                 190         


Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gln 
        195                 200                 205             


Gly Val Gln Ser Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    210                 215                 220                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr 
225                 230                 235                 240 


Leu Asp Tyr Tyr Gly Ile Gly Trp Phe Arg Gln Pro Pro Gly Lys Glu 
                245                 250                 255     


Arg Glu Ala Val Ser Tyr Ile Ser Ala Ser Ala Arg Thr Ile Leu Tyr 
            260                 265                 270         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        275                 280                 285             


Asn Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Arg Glu Asp Thr Ala 
    290                 295                 300                 


Val Tyr Tyr Cys Ala Arg Arg Arg Phe Ser Ala Ser Ser Val Asn Arg 
305                 310                 315                 320 


Trp Leu Ala Asp Asp Tyr Asp Val Trp Gly Arg Gly Thr Gln Val Ala 
                325                 330                 335     


Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Gly Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Val Gln Ser Gln 
        355                 360                 365             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly Ser 
    370                 375                 380                 


Leu Arg Leu Ser Cys Ala Ser Ser Gly Ser Ile Ala Gly Phe Glu Thr 
385                 390                 395                 400 


Val Thr Trp Ser Arg Gln Ala Pro Gly Lys Ser Leu Gln Trp Val Ala 
                405                 410                 415     


Ser Met Thr Lys Thr Asn Asn Glu Ile Tyr Ser Asp Ser Val Lys Gly 
            420                 425                 430         


Arg Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
        435                 440                 445             


Met Asn Ser Leu Lys Pro Glu Asp Thr Gly Val Tyr Phe Cys Lys Gly 
    450                 455                 460                 


Pro Glu Leu Arg Gly Gln Gly Ile Gln Val Thr Val Ser Ser Glu Pro 
465                 470                 475                 480 


Lys Thr Pro Lys Pro Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                485                 490                 495     


Gly Gly Gly Gly Ser Gln Gly Val Gln Ser Gln Val Gln Leu Val Glu 
            500                 505                 510         


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        515                 520                 525             


Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Val Met Thr Trp Val Arg 
    530                 535                 540                 


Gln Ala Pro Gly Lys Gly Pro Glu Trp Ile Ala Thr Ile Asn Thr Asp 
545                 550                 555                 560 


Gly Ser Thr Met Arg Asp Asp Ser Thr Lys Gly Arg Phe Thr Ile Ser 
                565                 570                 575     


Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Thr Ser Leu Lys 
            580                 585                 590         


Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Gly Arg Val Ile Ser 
        595                 600                 605             


Ala Ser Ala Ile Arg Gly Ala Val Arg Gly Pro Gly Thr Gln Val Thr 
    610                 615                 620                 


Val Ser Ser Glu Pro Lys Thr Pro Lys Pro Gln Gly Gly Gly Gly Asp 
625                 630                 635                 640 


Glu Leu Gly Pro Arg Leu Met Gly Lys Gly Gly Gly Gly Ser Asp Ile 
                645                 650                 655     


Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp 
            660                 665         


<210> 19
<211> 360
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ala Ala Gln Pro Ala Arg Arg Ala Arg Arg Thr 
            20                  25                  30          


Lys Leu Ser Gly Gly Gly Gly Asp Glu Leu Gly Pro Arg Leu Met Gly 
        35                  40                  45              


Lys Gly Gly Gly Gly Gln Gly Val Gln Ala Gln Leu Gln Leu Val Glu 
    50                  55                  60                  


Ser Gly Gly Gly Leu Val Gln Val Gly Gly Ser Leu Arg Leu Ser Cys 
65                  70                  75                  80  


Val Val Ser Gly Ser Asp Ile Ser Gly Ile Ala Met Gly Trp Tyr Arg 
                85                  90                  95      


Gln Ala Pro Gly Lys Arg Arg Glu Met Val Ala Asp Ile Phe Ser Gly 
            100                 105                 110         


Gly Ser Thr Asp Tyr Ala Gly Ser Val Lys Gly Arg Phe Thr Ile Ser 
        115                 120                 125             


Arg Asp Asn Ala Lys Lys Thr Ser Tyr Leu Gln Met Asn Asn Val Lys 
    130                 135                 140                 


Pro Glu Asp Thr Gly Val Tyr Tyr Cys Arg Leu Tyr Gly Ser Gly Asp 
145                 150                 155                 160 


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala His His Ser 
                165                 170                 175     


Glu Asp Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Gln Gly Val Gln Ala Gln Leu Gln Leu Val Glu 
        195                 200                 205             


Ser Gly Gly Gly Leu Val His Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    210                 215                 220                 


Ala Pro Ser Ala Ser Leu Pro Ser Thr Pro Phe Asn Pro Phe Asn Asn 
225                 230                 235                 240 


Met Val Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Met Val 
                245                 250                 255     


Ala Ser Ile Gly Leu Arg Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg 
            260                 265                 270         


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Asp Leu Gln Met 
        275                 280                 285             


Asp Ser Leu Arg Pro Glu Asp Ser Ala Thr Tyr Tyr Cys His Ile Glu 
    290                 295                 300                 


Tyr Thr His Tyr Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser Glu 
305                 310                 315                 320 


Pro Lys Thr Pro Lys Pro Gln Ser Gly Gly Gly Gly Asp Glu Leu Gly 
                325                 330                 335     


Pro Arg Leu Met Gly Lys Gly Gly Gly Gly Ser Asp Ile Cys Leu Pro 
            340                 345                 350         


Arg Trp Gly Cys Leu Trp Glu Asp 
        355                 360 


<210> 20
<211> 457
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Lys Leu Thr Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ala Ala Trp Met His Trp Val Arg Gln Ser Pro Asn Lys Arg Leu 
    50                  55                  60                  


Asp Trp Val Ala Arg Ile Lys Asp Lys Ser Asn Asn Tyr Ala Thr Asp 
65                  70                  75                  80  


Tyr Val Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Leu Tyr Leu Gln Met Asn Asn Leu Lys Glu Glu Asp Ser 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Val Thr Ser Glu Asp Trp Gly Gln Gly Val Met 
        115                 120                 125             


Val Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
    130                 135                 140                 


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
                165                 170                 175     


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
        195                 200                 205             


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
    210                 215                 220                 


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
225                 230                 235                 240 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
        275                 280                 285             


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
    290                 295                 300                 


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
305                 310                 315                 320 


Gln Asp Trp Pro Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
                325                 330                 335     


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
            340                 345                 350         


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
        355                 360                 365             


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
    370                 375                 380                 


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
385                 390                 395                 400 


Tyr Lys Asn Thr Gln Pro Ile Met Asn Thr Asn Gly Ser Tyr Phe Val 
                405                 410                 415     


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
            420                 425                 430         


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
        435                 440                 445             


Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455         


<210> 21
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Glu Ser Gln Thr Gln Leu Leu Gly Leu Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Met Arg Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Ala Thr Phe Asn Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Ile Ala Arg Ser Leu Asn Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Asn Thr Asn Thr Leu Gln Pro Gly Ile Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Val Ala Thr Phe Phe Cys Leu Gln Phe Gly 
            100                 105                 110         


Ser Trp Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln 
                165                 170                 175     


Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg 
        195                 200                 205             


His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro 
    210                 215                 220                 


Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 


