                         SEQUENCE LISTING

<110>  Crescendo Biologics Limited
 
<120>  Molecules that bind to CD137 and PSMA

<130>  P34657WO1

<150>  GB1718734.5
<151>  2017-11-13

<150>  GB1718735.2
<151>  2017-11-13

<150>  GB1808589.4
<151>  2018-05-24

<160>  902   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 of SEQ ID NO: 4

<400>  1

Ser His Trp Met Thr 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CRD2 of SEQ ID NO: 4

<400>  2

His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CRD3 of SEQ ID NO: 4

<400>  3

Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  4
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds CD137

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  5
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 of SEQ ID NO: 8

<400>  5

Ser Tyr Trp Met Thr 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 of SEQ ID NO: 8

<400>  6

His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 of SEQ ID NO: 8

<400>  7

Gly Gly Asp Gly Tyr Ser Asp Ser His Tyr Gly Val Asp Val 
1               5                   10                  


<210>  8
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds CD137

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Tyr Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  9
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR 1 of SEQ ID NO 12

<400>  9

Ser Tyr Trp Met Thr 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 of SEQ ID NO: 12

<400>  10

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR 3 of SEQ ID NO: 12

<400>  11

Gly Gly Leu Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  12
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  13
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR 1 of SEQ ID NO. 16

<400>  13

Asn Tyr Trp Met Thr 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CRD2 OF SEQ ID NO. 16

<400>  14

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO.16

<400>  15

Gly Gly Leu Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  16
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  17
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 20

<400>  17

Asn Tyr Trp Met Ile 
1               5   


<210>  18
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO:20

<400>  18

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  19
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CRD3 OF SEQ ID NO:20

<400>  19

Gly Gly Asp Gly Tyr Ser Gly Ser His His Gly Thr Asp Val 
1               5                   10                  


<210>  20
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Ile Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Gly Ser His His Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  21
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR 1 OF SEQ ID NO: 24

<400>  21

Ser Tyr Trp Met Ser 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO:24

<400>  22

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO:24

<400>  23

Gly Gly Glu Gly Tyr Ser Thr Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  24
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Ser Thr Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  25
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR 1 of SEQ ID NO: 28

<400>  25

Ser Tyr Trp Met Leu 
1               5   


<210>  26
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 28

<400>  26

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 28

<400>  27

Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Thr Asp Val 
1               5                   10                  


<210>  28
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  28

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Leu Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  29
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 32

<400>  29

Ser Tyr Trp Met Phe 
1               5   


<210>  30
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO:32

<400>  30

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO:32

<400>  31

Gly Gly Asp Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  32
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds CD137

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Phe Trp Phe Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  33
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 36

<400>  33

Asn Tyr Trp Met Thr 
1               5   


<210>  34
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 36

<400>  34

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  35
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 36

<400>  35

Gly Gly Leu Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  36
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Gly Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Asp 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  37
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 40

<400>  37

Asp Tyr Trp Met Asn 
1               5   


<210>  38
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 40

<400>  38

Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 40

<400>  39

Gly Gly Ala Gly Tyr Ser Met Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  40
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds CD137

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asn Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Thr Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ala Gly Tyr Ser Met Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  41
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 44

<400>  41

Asp Tyr Trp Met Asn 
1               5   


<210>  42
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 44

<400>  42

Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 44

<400>  43

Gly Gly Ala Gly Tyr Ser Met Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  44
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asn Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Thr Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ala Gly Tyr Ser Met Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  45
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 48

<400>  45

Ser Tyr Trp Met Leu 
1               5   


<210>  46
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 48

<400>  46

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  47
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 48

<400>  47

Gly Gly Asp Gly Tyr Ser Asn Ser His Phe Gly Thr Asp Val 
1               5                   10                  


<210>  48
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Leu Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asn Ser His Phe Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  49
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 52

<400>  49

Ser Tyr Trp Met Phe 
1               5   


<210>  50
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 52

<400>  50

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  51
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 52

<400>  51

Gly Gly Asp Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  52
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  52

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Phe Trp Phe Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  53
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 56

<400>  53

Asn Tyr Trp Met Asn 
1               5   


<210>  54
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 56

<400>  54

Asn Ile Lys Glu Asp Gly Ser Glu Asn Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 56

<400>  55

Gly Gly Glu Gly Tyr Ser Thr Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  56
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Glu Asp Gly Ser Glu Asn Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Ser Thr Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  57
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 60

<400>  57

Thr Tyr Trp Met Leu 
1               5   


<210>  58
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 60

<400>  58

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  59
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 60

<400>  59

Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Thr Asp Val 
1               5                   10                  


<210>  60
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Met Leu Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  61
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 64

<400>  61

Asn Tyr Trp Met Met 
1               5   


<210>  62
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 64

<400>  62

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Phe Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  63
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 64

<400>  63

Gly Gly Asp Gly Tyr Ser Ser Ser His Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  64
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Met Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Phe Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Ser Ser His Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  65
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 68

<400>  65

Ser Tyr Trp Met Asn 
1               5   


<210>  66
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 68

<400>  66

Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  67
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 68

<400>  67

Gly Gly Asp Ser Tyr Gly Tyr Arg Asp Tyr Gly Met Asp Val 
1               5                   10                  


<210>  68
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ser Tyr Gly Tyr Arg Asp Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  69
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 72

<400>  69

Thr His Trp Met Asn 
1               5   


<210>  70
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR 2 OF SEQ ID NO: 72

<400>  70

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  71
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 72

<400>  71

Gly Gly Val Gly Tyr Gly Asp Ser His Phe Gly Met Asp Val 
1               5                   10                  


<210>  72
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  72

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr His 
            20                  25                  30          


Trp Met Asn Trp Ala Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Gly Tyr Gly Asp Ser His Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Leu Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  73
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 76

<400>  73

Ser Tyr Trp Met Ile 
1               5   


<210>  74
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 76

<400>  74

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  75
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 76

<400>  75

Gly Gly Asp Asp Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  76
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Asp Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  77
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 80

<400>  77

Ser Tyr Trp Met Asn 
1               5   


<210>  78
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 80

<400>  78

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210>  79
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 80

<400>  79

Gly Gly Phe Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  80
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds CD137

<400>  80

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  81
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 84

<400>  81

Ser Tyr Trp Met Phe 
1               5   


<210>  82
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 84

<400>  82

Asn Val Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  83
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 84

<400>  83

Gly Gly Glu Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  84
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds CD137

<400>  84

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Phe Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Val Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  85
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 88

<400>  85

Asn Tyr Trp Met Asn 
1               5   


<210>  86
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 88

<400>  86

Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  87
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 88

<400>  87

Gly Gly Glu Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  88
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  88

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  89
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 92

<400>  89

Ser Tyr Trp Met Asn 
1               5   


<210>  90
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 92

<400>  90

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  91
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 92

<400>  91

Gly Gly Glu Gly Tyr Gly Asp Asp His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  92
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  92

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Thr Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Asp Asp His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  93
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 96

<400>  93

Ser Tyr Trp Met Ser 
1               5   


<210>  94
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 96

<400>  94

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  95
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 96

<400>  95

Gly Gly Glu Gly Tyr Gly Asp Tyr His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  96
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  96

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Asp Tyr His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  97
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 100

<400>  97

Ser Tyr Trp Met Asn 
1               5   


<210>  98
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 100

<400>  98

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  99
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 100

<400>  99

Gly Gly Asp Ser Tyr Gly Tyr Arg Asp Tyr Gly Met Asp Val 
1               5                   10                  


<210>  100
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  100

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ser Tyr Gly Tyr Arg Asp Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  101
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 104

<400>  101

Thr His Trp Met Asn 
1               5   


<210>  102
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 104

<400>  102

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  103
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 104

<400>  103

Gly Gly Val Gly Tyr Gly Asp Ser His Phe Gly Met Asp Val 
1               5                   10                  


<210>  104
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  104

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Thr His 
            20                  25                  30          


Trp Met Asn Trp Ala Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Gly Tyr Gly Asp Ser His Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Leu Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  105
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 108

<400>  105

Ser Tyr Trp Met Leu 
1               5   


<210>  106
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 108

<400>  106

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  107
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 108

<400>  107

Gly Gly Glu Gly Tyr Ser Asp Ser His His Gly Thr Asp Val 
1               5                   10                  


<210>  108
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  108

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Leu Trp Phe Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Lys Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Ser Asp Ser His His Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  109
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 112

<400>  109

Asn Tyr Trp Met Asn 
1               5   


<210>  110
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 112

<400>  110

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  111
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 112

<400>  111

Gly Gly Asp Asn Tyr Ala Tyr Arg Asp Phe Gly Met Asp Val 
1               5                   10                  


<210>  112
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  112

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Asn Tyr Ala Tyr Arg Asp Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  113
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 116

<400>  113

Asn Tyr Trp Met Phe 
1               5   


<210>  114
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 116

<400>  114

Asn Val Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 116

<400>  115

Gly Gly Glu Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  116
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  116

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Phe Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Val Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  117
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 120

<400>  117

Ser Tyr Trp Met Asn 
1               5   


<210>  118
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 120

<400>  118

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  119
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 120

<400>  119

Gly Gly Glu Glu Tyr Gly Ser Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  120
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  120

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Glu Tyr Gly Ser Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Leu Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  121
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 124

<400>  121

Ser Tyr Trp Met Asn 
1               5   


<210>  122
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 124

<400>  122

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  123
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 124

<400>  123

Gly Gly Asp Ser Tyr Gly Tyr Arg Asp Tyr Gly Met Asp Val 
1               5                   10                  


<210>  124
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ser Tyr Gly Tyr Arg Asp Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  125
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 128

<400>  125

Ser Tyr Trp Met Asn 
1               5   


<210>  126
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 128

<400>  126

Asn Ile Asn Gln Asn Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  127
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 128

<400>  127

Gly Gly Phe Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  128
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  128

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asn Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Asn Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  129
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 132

<400>  129

Asn Tyr Trp Met Thr 
1               5   


<210>  130
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 132

<400>  130

Asn Ile Asn Gln Asp Glu Ser Glu Glu Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  131
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(131)
<223>  CDR3 OF SEQ ID NO: 132

<400>  131

Gly Gly Asp Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  132
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Glu Ser Glu Glu Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  133
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 136

<400>  133

Asn Tyr Trp Met Asn 
1               5   


<210>  134
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 136

<400>  134

Asn Ile Lys Glu Asp Gly Ser Glu Asn Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  135
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 136

<400>  135

Gly Gly Glu Gly Tyr Ser Thr Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  136
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  136

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Glu Asp Gly Ser Glu Asn Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Ser Thr Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  137
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 140

<400>  137

Asn Tyr Trp Met Asn 
1               5   


<210>  138
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 140

<400>  138

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  139
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 140

<400>  139

Gly Gly Glu Gly Tyr Gly Glu Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  140
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  140

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Glu Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  141
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 144

<400>  141

Thr Tyr Trp Met Asn 
1               5   


<210>  142
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 144

<400>  142

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  143
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 144

<400>  143

Gly Gly Asp Ser Tyr Gly Tyr Arg Asp Tyr Gly Met Asp Val 
1               5                   10                  


<210>  144
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH that binds to CD137

<400>  144

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Ser Tyr Gly Tyr Arg Asp Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  145
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 148

<400>  145

Tyr Tyr Trp Met Ile 
1               5   


<210>  146
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 148

<400>  146

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  147
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 148

<400>  147

Gly Gly Asp Gly Tyr Ser Asn Ser His Phe Gly Met Asp Val 
1               5                   10                  


<210>  148
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  148

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr 
            20                  25                  30          


Trp Met Ile Trp Phe Arg Gln Ala Pro Gly Glu Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Asn Ala Thr Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asn Ser His Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  149
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  CDR1 OF SEQ ID NO: 152

<400>  149

Asn Tyr Trp Met Ile 
1               5   


<210>  150
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 152

<400>  150

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  151
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 152

<400>  151

Gly Gly Glu Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  152
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Ile Trp Tyr Arg Gln Ala Pro Gly Glu Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  153
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 156

<400>  153

Asn Tyr Trp Met Asn 
1               5   


<210>  154
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 156

<400>  154

Asn Ile Asn Gln Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  155
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 156

<400>  155

Gly Gly Phe Gly Tyr Gly Asp Ser His Phe Gly Met Asp Val 
1               5                   10                  


<210>  156
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  156

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Gly Tyr Gly Asp Ser His Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  157
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 160

<400>  157

Asn Tyr Trp Met Phe 
1               5   


<210>  158
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 160

<400>  158

Asn Val Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  159
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 160

<400>  159

Gly Gly Glu Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  160
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  160

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Phe Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Val Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  161
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 164

<400>  161

Asn Tyr Trp Met Phe 
1               5   


<210>  162
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 164

<400>  162

Asn Val Asn Gln Asn Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  163
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 164

<400>  163

Gly Gly Glu Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
1               5                   10                  


<210>  164
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  164

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Phe Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Val Asn Gln Asn Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Ser Asp Ser His Tyr Gly Thr Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  165
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 168

<400>  165

Asn Tyr Trp Met Asn 
1               5   


<210>  166
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 168

<400>  166

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  167
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 168

<400>  167

Gly Gly Glu Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  168
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  168

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asp Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  169
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 172

<400>  169

Asn Tyr Trp Met Ile 
1               5   


<210>  170
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 172

<400>  170

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  171
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 172

<400>  171

Gly Gly Asp Gly Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  172
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Ile Trp Tyr Arg Gln Ala Pro Gly Glu Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  173
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 176

<400>  173

Asp Tyr Trp Met Ile 
1               5   


<210>  174
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 176

<400>  174

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  175
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 176

<400>  175

Gly Gly Asp Gly Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  176
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  176

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Ile Trp Tyr Arg Gln Ala Pro Gly Glu Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  177
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 180

<400>  177

Lys Tyr Trp Met Ile 
1               5   


<210>  178
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 180

<400>  178

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  179
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 180

<400>  179

Gly Gly Asp Asp Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  180
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  180

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Trp Met Ile Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Asn Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Asp Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  181
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 184

<400>  181

Asn Tyr Trp Met Ser 
1               5   


<210>  182
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 184

<400>  182

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  183
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 184

<400>  183

Gly Gly Glu Glu Tyr Ser Ser Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  184
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  184

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Glu Tyr Ser Ser Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  185
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 188

<400>  185

Asn Tyr Trp Met Asn 
1               5   


<210>  186
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 188

<400>  186

Asn Ile Lys Gln Asp Gly Ser Glu Asn Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  187
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 188

<400>  187

Gly Gly Glu Gly Tyr Ser Thr Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  188
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  188

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ile Ala Ser Gly Phe Ser Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Asn Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Ser Thr Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
        115                 120             


<210>  189
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 192

<400>  189

Ser Tyr Trp Met Ser 
1               5   


<210>  190
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 192

<400>  190

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  191
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 192

<400>  191

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  192
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  192

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  193
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 196

<400>  193

Ser Tyr Trp Met Leu 
1               5   


<210>  194
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 196

<400>  194

Asn Val Asn Gln Asp Gly Ser Glu Asn Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  195
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 196

<400>  195

Gly Gly Glu Asp Tyr Gly Asn Ser His Phe Gly Met Asp Val 
1               5                   10                  


<210>  196
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  196

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Gly Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Leu Trp Phe Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Val Asn Gln Asp Gly Ser Glu Asn Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met His Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Asp Tyr Gly Asn Ser His Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  197
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 200

<400>  197

Asn Tyr Trp Met Ile 
1               5   


<210>  198
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 200

<400>  198

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  199
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 200

<400>  199

Gly Gly Asp Gly Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  200
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  200

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Ile Trp Tyr Arg Gln Ala Pro Gly Glu Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  201
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 204

<400>  201

Asn Tyr Trp Met Ile 
1               5   


<210>  202
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 204

<400>  202

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  203
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 204

<400>  203

Gly Gly Asp Gly Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  204
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  204

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Ile Trp Tyr Arg Gln Ala Pro Gly Glu Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  205
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 208

<400>  205

Lys Tyr Trp Met Ile 
1               5   


<210>  206
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 208

<400>  206

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  207
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 208

<400>  207

Gly Gly Asp Asp Tyr Ser Ile Ser His Phe Gly Met Asp Val 
1               5                   10                  


<210>  208
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  208

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ile Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Trp Met Ile Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Asp Tyr Ser Ile Ser His Phe Gly Met Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Arg Val Thr Val Ser Ser 
        115                 120             


<210>  209
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 212

<400>  209

Lys Tyr Trp Met Ile 
1               5   


<210>  210
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 212

<400>  210

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  211
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 212

<400>  211

Gly Gly Asp Asp Tyr Ser His Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  212
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  212

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ile Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Lys Tyr 
            20                  25                  30          


Trp Met Ile Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Asp Tyr Ser His Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  213
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 216

<400>  213

Asn Tyr Trp Met Asn 
1               5   


<210>  214
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 216

<400>  214

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  215
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 216

<400>  215

Gly Gly Phe Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  216
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  216

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  217
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 220

<400>  217

Ser Tyr Trp Leu Asn 
1               5   


<210>  218
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 220

<400>  218

Asn Ile Asn Gln Asp Gly Ser Glu Asn Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  219
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 220

<400>  219

Gly Gly Glu Asp Tyr Gly Asn Ser His Phe Gly Met Asp Val 
1               5                   10                  


<210>  220
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  220

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Tyr 
            20                  25                  30          


Trp Leu Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Asn Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met His Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Asp Tyr Gly Asn Ser His Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  221
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 224

<400>  221

Ser Tyr Trp Met Ser 
1               5   


<210>  222
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 224

<400>  222

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  223
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 224

<400>  223

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  224
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  224

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  225
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 228

<400>  225

Asp Tyr Trp Met Asn 
1               5   


<210>  226
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO:228

<400>  226

Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  227
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 228

<400>  227

Gly Gly Glu Gly Tyr Gly Asp Asn His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  228
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  228

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Glu Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Asp Asn His Tyr Gly Met Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  229
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 232

<400>  229

Ser Tyr Trp Met Asn 
1               5   


<210>  230
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 232

<400>  230

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  231
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 232

<400>  231

Gly Gly Pro Asp Tyr Gly Asp Leu His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  232
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  232

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Glu Ala Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Asp Tyr Gly Asp Leu His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  233
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 236

<400>  233

Arg Tyr Trp Met Ser 
1               5   


<210>  234
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 236

<400>  234

Asn Ile Asn Gln Asp Gly Arg Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  235
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 236

<400>  235

Gly Gly Glu Gly Tyr Gly Asp Tyr His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  236
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  236

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Arg Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Asp Tyr His Tyr Gly Met Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  237
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 240

<400>  237

Asn Tyr Trp Met Ile 
1               5   


<210>  238
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 240

<400>  238

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  239
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 240

<400>  239

Gly Gly Asp Gly Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  240
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  240

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Pro Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Ile Trp Tyr Arg Gln Ala Pro Gly Glu Lys Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Thr Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  241
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 244

<400>  241

Asn Tyr Trp Met Asn 
1               5   


<210>  242
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 244

<400>  242

Asn Ile Asn Gln Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  243
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 244

<400>  243

Gly Gly Phe Gly Tyr Gly Asp Ser His Phe Gly Met Asp Val 
1               5                   10                  


<210>  244
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  244

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Asn Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Gly Tyr Gly Asp Ser His Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  245
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 248

<400>  245

Asn Tyr Trp Met Asn 
1               5   


<210>  246
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 248

<400>  246

Asn Ile Asn Gln Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  247
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 248

<400>  247

Gly Gly Phe Gly Tyr Gly Asp Ser His Phe Gly Met Asp Val 
1               5                   10                  


<210>  248
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  248

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Phe Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Gly Tyr Gly Asp Ser His Phe Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  249
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 252

<400>  249

Ser Phe Trp Met Asn 
1               5   


<210>  250
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 252

<400>  250

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  251
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 252

<400>  251

Gly Gly Pro Asp Tyr Gly Asp Leu His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  252
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  252

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Phe 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Glu Ala Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Asp Tyr Gly Asp Leu His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  253
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 256

<400>  253

Ser Tyr Trp Met Asn 
1               5   


<210>  254
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 256

<400>  254

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  255
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 256

<400>  255

Gly Gly Pro Asp Tyr Gly Asp Leu His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  256
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  256

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Glu Ala Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Asp Tyr Gly Asp Leu His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  257
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 260

<400>  257

Asn Tyr Trp Met Ile 
1               5   


<210>  258
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 260

<400>  258

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  259
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 260

<400>  259

Gly Gly Glu Asp Tyr Gly Asn Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  260
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  260

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Ile Trp Tyr Arg Gln Ala Pro Gly Glu Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met His Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Asp Tyr Gly Asn Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  261
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 264

<400>  261

Asn Tyr Trp Met Asn 
1               5   


<210>  262
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 264

<400>  262

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  263
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 264

<400>  263

Gly Gly Glu Gly Tyr Gly Ile Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  264
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  264

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Ile Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  265
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 268

<400>  265

Ser Tyr Trp Met Ser 
1               5   


<210>  266
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 268

<400>  266

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  267
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 268

<400>  267

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  268
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  268

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  269
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 272

<400>  269

Asn Tyr Trp Met Ile 
1               5   


<210>  270
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 272

<400>  270

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  271
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 272

<400>  271

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  272
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  272

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  273
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 276

<400>  273

Asn Tyr Trp Met Asn 
1               5   


<210>  274
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 276

<400>  274

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  275
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 276

<400>  275

Gly Gly Thr Gly Tyr Gly Ser Asp His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  276
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  276

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Gly Tyr Gly Ser Asp His Tyr Gly Met Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  277
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 280

<400>  277

Asn Tyr Trp Met Asn 
1               5   


<210>  278
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 280

<400>  278

Asn Ile Asn Gln Asp Gly Ser Glu Asn Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  279
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 280

<400>  279

Gly Gly Phe Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  280
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  280

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Asn Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Arg Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Phe Gly Tyr Gly Asp Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  281
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 284

<400>  281

Asn Tyr Trp Met Ile 
1               5   


<210>  282
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 284

<400>  282

Asn Ile Asn Gln Asn Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210>  283
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 284

<400>  283

Gly Gly Ala Asp Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  284
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  284

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Tyr 
            20                  25                  30          


Trp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Glu Leu Glu Trp Leu 
        35                  40                  45              


Ala Asn Ile Asn Gln Asn Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Ala Asp Tyr Ser Asn Ser His Tyr Gly Met Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  285
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 288

<400>  285

Ser Tyr Trp Met Ser 
1               5   


<210>  286
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 288

<400>  286

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  287
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 288

<400>  287

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  288
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  288

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser Leu His 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  289
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 292

<400>  289

Ser Tyr Trp Met Asn 
1               5   


<210>  290
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 292

<400>  290

Asn Ile Asn Pro Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Gln 
1               5                   10                  15      


Gly 
    


<210>  291
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 292

<400>  291

Gly Gly Pro Gly Tyr Gly Asp Leu His Tyr Gly Met Asp Val 
1               5                   10                  


<210>  292
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  292

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Glu Ala Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Pro Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg His Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Arg Val Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Pro Gly Tyr Gly Asp Leu His Tyr Gly Met Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  293
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 296

<400>  293

Asn Tyr Trp Met Asn 
1               5   


<210>  294
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 296

<400>  294

Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  295
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 296

<400>  295

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  296
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  296

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  297
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 300

<400>  297

Asp Tyr Tyr Met Ser 
1               5   


<210>  298
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 300

<400>  298

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  299
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 300

<400>  299

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  300
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  300

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  301
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 304

<400>  301

Asn Tyr Trp Met Asn 
1               5   


<210>  302
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 304

<400>  302

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  303
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 304

<400>  303

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  304
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  304

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  305
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 308

<400>  305

Asn Tyr Trp Met Asn 
1               5   


<210>  306
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 308

<400>  306

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  307
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 308

<400>  307

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  308
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  308

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  309
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 312

<400>  309

Asn Tyr Trp Met Asn 
1               5   


<210>  310
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 312

<400>  310

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  311
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 312

<400>  311

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  312
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  312

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  313
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 316

<400>  313

Asn Tyr Trp Met Asn 
1               5   


<210>  314
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 316

<400>  314

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  315
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 316

<400>  315

Gly Gly Glu Gly Tyr Gly Val Asn His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  316
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  316

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asn His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  317
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 320

<400>  317

Asp Tyr Tyr Met Ser 
1               5   


<210>  318
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 320

<400>  318

Asn Ile Lys Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  319
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 320

<400>  319

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  320
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  320

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  321
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 324

<400>  321

Asn Tyr Trp Met Asn 
1               5   


<210>  322
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 324

<400>  322

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  323
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 324

<400>  323

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  324
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  324

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  325
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 328

<400>  325

Asn Tyr Trp Met Asn 
1               5   


<210>  326
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 328

<400>  326

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  327
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 328

<400>  327

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  328
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  328

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  329
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 332

<400>  329

Asn Tyr Trp Met Asn 
1               5   


<210>  330
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 332

<400>  330

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  331
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 332

<400>  331

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  332
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  332

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  333
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 336

<400>  333

Asn Tyr Trp Met Asn 
1               5   


<210>  334
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 336

<400>  334

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  335
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 336

<400>  335

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  336
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  336

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  337
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 340

<400>  337

Asn Tyr Trp Met Asn 
1               5   


<210>  338
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 340

<400>  338

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  339
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 340

<400>  339

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  340
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  340

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser Leu His 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  341
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 344

<400>  341

Asn Tyr Trp Met Asn 
1               5   


<210>  342
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 344

<400>  342

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  343
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 344

<400>  343

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  344
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  344

Gln Val Gln Leu Gly Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  345
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 348

<400>  345

Asn Tyr Trp Met Asn 
1               5   


<210>  346
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 348

<400>  346

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  347
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 348

<400>  347

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  348
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  348

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  349
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 352

<400>  349

Asn Tyr Trp Met Asn 
1               5   


<210>  350
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 352

<400>  350

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  351
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO:352

<400>  351

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  352
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  352

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Gly Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  353
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 356

<400>  353

Asp Tyr Gly Met Ser 
1               5   


<210>  354
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 356

<400>  354

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  355
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 356

<400>  355

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  356
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  356

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  357
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 360

<400>  357

Ser His Trp Met Thr 
1               5   


<210>  358
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 360

<400>  358

His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  359
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 360

<400>  359

Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  360
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  360

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  361
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 364

<400>  361

Ser His Trp Met Thr 
1               5   


<210>  362
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 364

<400>  362

His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  363
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 364

<400>  363

Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  364
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  364

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  365
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 368

<400>  365

Ser His Trp Met Thr 
1               5   


<210>  366
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 368

<400>  366

His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  367
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 368

<400>  367

Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  368
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  368

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  369
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 372

<400>  369

Ser His Trp Met Thr 
1               5   


<210>  370
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 372

<400>  370

His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  371
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 372

<400>  371

Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  372
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  372

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  373
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 376

<400>  373

Ser His Trp Met Thr 
1               5   


<210>  374
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 376

<400>  374

His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  375
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 376

<400>  375

Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  376
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  376

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  377
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 380

<400>  377

Ser His Trp Met Thr 
1               5   


<210>  378
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 380

<400>  378

His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  379
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 380

<400>  379

Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  380
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  380

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  381
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 384

<400>  381

Ser His Trp Met Thr 
1               5   


<210>  382
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 384

<400>  382

His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  383
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 384

<400>  383

Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  384
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  384

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  385
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 388

<400>  385

Ser His Trp Met Thr 
1               5   


<210>  386
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 388

<400>  386

His Ile Lys Glu Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  387
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 388

<400>  387

Gly Gly Val Gly Tyr Ser Ile Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  388
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  388

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Gly Tyr Ser Ile Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  389
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 392

<400>  389

Ser His Trp Met Thr 
1               5   


<210>  390
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 392

<400>  390

His Ile Lys Glu Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  391
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 392

<400>  391

Gly Gly Glu Gly Tyr Ser Ile Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  392
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  392

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Ser Ile Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  393
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 396

<400>  393

Ser His Trp Met Thr 
1               5   


<210>  394
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 396

<400>  394

His Ile Lys Glu Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  395
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 396

<400>  395

Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  396
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  396

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  397
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 400

<400>  397

Ser His Trp Met Thr 
1               5   


<210>  398
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 400

<400>  398

His Ile Lys Glu Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  399
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 400

<400>  399

Gly Gly Asp Gly Tyr Ser Ile Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  400
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  400

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Ile Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  401
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 404

<400>  401

Ser His Trp Met Thr 
1               5   


<210>  402
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 404

<400>  402

His Ile Lys Glu Gly Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  403
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 404

<400>  403

Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  404
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  404

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Gly Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  405
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 408

<400>  405

Ser His Trp Met Thr 
1               5   


<210>  406
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 408

<400>  406

His Ile Lys Glu Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  407
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 408

<400>  407

Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  408
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  408

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  409
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 412

<400>  409

Ser His Trp Met Thr 
1               5   


<210>  410
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 412

<400>  410

His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  411
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 412

<400>  411

Gly Gly Glu Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  412
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  412

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  413
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 416

<400>  413

Ser His Trp Met Thr 
1               5   


<210>  414
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 416

<400>  414

His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  415
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 416

<400>  415

Gly Gly Val Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  416
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  416

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  417
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 420

<400>  417

Ser His Trp Met Thr 
1               5   


<210>  418
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 420

<400>  418

His Ile Lys Glu Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  419
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 420

<400>  419

Gly Gly Val Gly Tyr Ser Ile Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  420
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  420

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Val Gly Tyr Ser Ile Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  421
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 424

<400>  421

Ser His Trp Met Thr 
1               5   


<210>  422
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 424

<400>  422

His Ile Lys Glu Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  423
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 424

<400>  423

Gly Gly Glu Gly Tyr Ser Ile Ser His Phe Gly Val Asp Val 
1               5                   10                  


<210>  424
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  424

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Glu Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Ser Ile Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  425
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 428

<400>  425

Asp Tyr Tyr Met Ser 
1               5   


<210>  426
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 428

<400>  426

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  427
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 428

<400>  427

Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  428
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  428

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  429
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 432

<400>  429

Asp Tyr Tyr Met Ser 
1               5   


<210>  430
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 432

<400>  430

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  431
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 432

<400>  431

Glu Asp Ser Arg Ile Pro Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  432
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  432

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Lys Glu Asp Ser Arg Ile Pro Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  433
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 436

<400>  433

Asp Tyr Tyr Met Ser 
1               5   


<210>  434
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 436

<400>  434

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  435
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 436

<400>  435

Glu Asp Ser Arg Ile Pro Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  436
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  436

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Lys Glu Asp Ser Arg Ile Pro Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  437
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 440

<400>  437

Asp Tyr Tyr Met Ser 
1               5   


<210>  438
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 440

<400>  438

Tyr Ile Ser Gly Ser Gly Asp Val Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  439
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 440

<400>  439

Glu Asp Ser Arg Ile Pro Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  440
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  440

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Val Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Lys Glu Asp Ser Arg Ile Pro Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  441
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 444

<400>  441

Asp Tyr Tyr Met Ser 
1               5   


<210>  442
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 444

<400>  442

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  443
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 444

<400>  443

Glu Asp Ser Arg Ile Pro Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  444
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  444

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Lys Glu Asp Ser Arg Ile Pro Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  445
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 448

<400>  445

Asp Tyr Tyr Met Ser 
1               5   


<210>  446
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 448

<400>  446

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  447
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 448

<400>  447

Glu Asp Ser Arg Ile Pro Gly Thr Thr Asp Phe Asp Ser 
1               5                   10              


<210>  448
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  448

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Lys Glu Asp Ser Arg Ile Pro Gly Thr Thr Asp Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  449
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 452

<400>  449

Asp Tyr Tyr Met Ser 
1               5   


<210>  450
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 452

<400>  450

Tyr Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  451
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 452

<400>  451

Glu Asp Ile Arg Met Thr Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  452
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  452

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ile Arg Met Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  453
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 456

<400>  453

Asp Tyr Tyr Met Ser 
1               5   


<210>  454
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 456

<400>  454

His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  455
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 456

<400>  455

Glu Asp Ser Arg Met Pro Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  456
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  456

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Arg Met Pro Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  457
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 460

<400>  457

Asp Tyr Tyr Met Thr 
1               5   


<210>  458
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 460

<400>  458

Tyr Ile Ser Gly Ser Gly Asp Thr Ile Asp Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  459
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 460

<400>  459

Glu Asp Ser Arg Ile Ala Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  460
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  460

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Thr Ile Asp Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Arg Ile Ala Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  461
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 464

<400>  461

Asp Tyr Tyr Met Thr 
1               5   


<210>  462
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 464

<400>  462

Tyr Ile Ser Ser Ser Gly Ser Asn Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  463
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 464

<400>  463

Glu Asp Ser Arg Leu Ser Gly Thr Thr Asp Phe Asp Tyr 
1               5                   10              


<210>  464
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  464

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Asn Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Arg Leu Ser Gly Thr Thr Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  465
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 468

<400>  465

Asp Tyr Tyr Met Thr 
1               5   


<210>  466
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 468

<400>  466

Tyr Ile Ser Gly Ser Gly Asp Thr Ile Asp Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  467
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 468

<400>  467

Glu Asp Ser Arg Ile Ala Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  468
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  468

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Thr Ile Asp Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Arg Ile Ala Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  469
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 472

<400>  469

Asp Tyr Tyr Met Ser 
1               5   


<210>  470
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 472

<400>  470

His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  471
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 472

<400>  471

Glu Asp Ile Arg Met Thr Gly Thr Thr Asp Phe Asp His 
1               5                   10              


<210>  472
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  472

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Lys Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ile Arg Met Thr Gly Thr Thr Asp Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  473
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 476

<400>  473

Asp Tyr Tyr Met Ser 
1               5   


<210>  474
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 476

<400>  474

His Ile Ser Ser Ser Gly Asn Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  475
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 476

<400>  475

Glu Asp Pro Arg Leu Pro Gly Thr Thr Asp Phe Asp Tyr 
1               5                   10              


<210>  476
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  476

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ser Gly Asn Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Leu Pro Gly Thr Thr Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  477
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 480

<400>  477

Asp Tyr Tyr Met Thr 
1               5   


<210>  478
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 480

<400>  478

Tyr Ile Ser Gly Ser Gly Asp Thr Ile Asp Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  479
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 480

<400>  479

Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His 
1               5                   10              


<210>  480
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  480

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Thr Ile Asp Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  481
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 484

<400>  481

Asp Tyr Tyr Met Ser 
1               5   


<210>  482
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 484

<400>  482

His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  483
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 484

<400>  483

Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His 
1               5                   10              


<210>  484
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  484

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  485
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 488

<400>  485

Asp Tyr Tyr Met Ser 
1               5   


<210>  486
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 488

<400>  486

His Ile Ser Ser Ser Gly Ser Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  487
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 488

<400>  487

Glu Asp Pro Arg Leu Thr Gly Thr Thr Asp Phe Asp Tyr 
1               5                   10              


<210>  488
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  488

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ser Gly Ser Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Leu Thr Gly Thr Thr Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Ala Leu Val Thr Val Ser Ser 
        115                 120         


<210>  489
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 492

<400>  489

Asp Tyr Tyr Met Ser 
1               5   


<210>  490
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 492

<400>  490

Tyr Ile Ser Ser Ser Gly Ser Thr Ile Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  491
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 492

<400>  491

Glu Asp Pro Arg Ile Ser Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  492
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  492

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Ile Ser Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  493
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 496

<400>  493

Asp Tyr Tyr Met Ser 
1               5   


<210>  494
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 496

<400>  494

His Ile Ser Ser Ser Gly Asn Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  495
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 496

<400>  495

Glu Asp Pro Arg Leu Pro Gly Thr Thr Asp Phe Asp Tyr 
1               5                   10              


<210>  496
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  496

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ser Gly Asn Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Leu Pro Gly Thr Thr Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  497
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 500

<400>  497

Asp Tyr Tyr Met Ser 
1               5   


<210>  498
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 500

<400>  498

Tyr Ile Ser Gly Thr Gly Ile Thr Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  499
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 500

<400>  499

Glu Asp Pro Arg Leu Pro Gly Thr Ser Glu Phe Asp Asn 
1               5                   10              


<210>  500
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  500

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Thr Gly Ile Thr Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Leu Pro Gly Thr Ser Glu Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  501
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 504

<400>  501

Asp Tyr Tyr Met Ser 
1               5   


<210>  502
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 504

<400>  502

His Ile Ser Ser Ser Gly Ser Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  503
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 504

<400>  503

Glu Asp Pro Arg Met Pro Gly Thr Phe Asp Phe Asp Asn 
1               5                   10              


<210>  504
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  504

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ser Gly Ser Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Met Pro Gly Thr Phe Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  505
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 508

<400>  505

Asp Tyr Tyr Met Ser 
1               5   


<210>  506
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 508

<400>  506

His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  507
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 508

<400>  507

Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His 
1               5                   10              


<210>  508
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  508

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  509
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 512

<400>  509

Asp Tyr Tyr Met Ser 
1               5   


<210>  510
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 512

<400>  510

His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  511
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 512

<400>  511

Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His 
1               5                   10              


<210>  512
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  512

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asp Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  513
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 516

<400>  513

Asp Tyr Tyr Met Ser 
1               5   


<210>  514
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 516

<400>  514

His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  515
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 516

<400>  515

Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His 
1               5                   10              


<210>  516
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  516

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Thr Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  517
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 520

<400>  517

Asp Tyr Tyr Met Ser 
1               5   


<210>  518
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 520

<400>  518

His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  519
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 520

<400>  519

Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His 
1               5                   10              


<210>  520
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  520

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  521
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 524

<400>  521

Asp Tyr Tyr Met Ser 
1               5   


<210>  522
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 524

<400>  522

His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210>  523
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 524

<400>  523

Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His 
1               5                   10              


<210>  524
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  524

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  525
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 528

<400>  525

Asp Tyr Tyr Met Ser 
1               5   


<210>  526
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 528

<400>  526

His Ile Ser Ser Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  527
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 528

<400>  527

Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  528
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  528

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  529
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 532

<400>  529

Asp Tyr Tyr Met Thr 
1               5   


<210>  530
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 532

<400>  530

Tyr Ile Ser Ser Ser Gly Ser Thr Ile Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  531
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 532

<400>  531

Glu Asp Ile Arg Met Ser Gly Thr Thr Asp Phe Asp Tyr 
1               5                   10              


<210>  532
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  532

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Asn Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Asp Ile Arg Met Ser Gly Thr Thr Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  533
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 536

<400>  533

Asp Tyr Tyr Met Ser 
1               5   


<210>  534
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 536

<400>  534

His Ile Ser Ser Ser Gly Ser Ser Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  535
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 536

<400>  535

Glu Asp Pro Arg Leu Ser Gly Thr Ile Asp Phe Asp Ser 
1               5                   10              


<210>  536
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  536

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ser Gly Ser Ser Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Leu Ser Gly Thr Ile Asp Phe Asp Ser Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  537
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 540

<400>  537

Asp Tyr Tyr Met Ser 
1               5   


<210>  538
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 540

<400>  538

His Ile Gly Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  539
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 540

<400>  539

Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His 
1               5                   10              


<210>  540
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  540

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Gly Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  541
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 544

<400>  541

Asp Tyr Tyr Met Ser 
1               5   


<210>  542
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 544

<400>  542

Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  543
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 544

<400>  543

Glu Asp Pro Arg Val Pro Gly Thr Thr Asn Phe Asp Tyr 
1               5                   10              


<210>  544
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  544

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Val Pro Gly Thr Thr Asn Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  545
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 548

<400>  545

Asp Tyr Tyr Met Thr 
1               5   


<210>  546
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 548

<400>  546

Tyr Ile Ser Gly Ser Gly Ser Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  547
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 548

<400>  547

Glu Asp Gly Arg Ile Pro Gly Thr Thr Asp Phe Asp His 
1               5                   10              


<210>  548
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  548

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Met Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Ser Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Asp Gly Arg Ile Pro Gly Thr Thr Asp Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  549
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 552

<400>  549

Asp Tyr Tyr Met Ser 
1               5   


<210>  550
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 552

<400>  550

His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Asp 
    


<210>  551
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 552

<400>  551

Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His 
1               5                   10              


<210>  552
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  552

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Gly Ser Gly Thr Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ile Arg Met Pro Gly Thr Thr Asp Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  553
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 556

<400>  553

Asp Tyr Phe Met Ser 
1               5   


<210>  554
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 556

<400>  554

His Ile Ser Ser Ser Gly Asn Ser Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  555
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 556

<400>  555

Glu Asp Pro Arg Leu Pro Gly Thr Thr Asp Phe Asp Tyr 
1               5                   10              


<210>  556
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  556

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Asp Tyr 
            20                  25                  30          


Phe Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ser Gly Asn Ser Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Asp Pro Arg Leu Pro Gly Thr Thr Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  557
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 560

<400>  557

Asp Ser Tyr Met Ser 
1               5   


<210>  558
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 560

<400>  558

His Ile Ser Asn Ser Gly Ser Thr Ile Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  559
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 560

<400>  559

Glu Asp Pro Arg Leu Pro Gly Thr Ser Asp Phe Asp Tyr 
1               5                   10              


<210>  560
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  560

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Asn Ser Gly Ser Thr Ile Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Leu Pro Gly Thr Ser Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  561
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 564

<400>  561

Asp Tyr Tyr Met Ser 
1               5   


<210>  562
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 564

<400>  562

His Ile Ser Ser Ser Gly Ser Ser Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  563
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 564

<400>  563

Glu Asp Pro Arg Leu Ser Gly Thr Thr Asp Phe Asp Gln 
1               5                   10              


<210>  564
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  564

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ser Gly Ser Ser Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Leu Ser Gly Thr Thr Asp Phe Asp Gln Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  565
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 568

<400>  565

Ser Tyr Trp Met Ser 
1               5   


<210>  566
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 568

<400>  566

His Ile Ser Ser Ser Gly Ser Thr Ile Asp Tyr Ala Glu Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  567
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 568

<400>  567

Glu Asp Pro Arg Met Thr Gly Thr Thr Asp Phe Asp Tyr 
1               5                   10              


<210>  568
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  568

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ser Gly Ser Thr Ile Asp Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Met Thr Gly Thr Thr Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  569
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 572

<400>  569

Asn Tyr Phe Met Ser 
1               5   


<210>  570
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 572

<400>  570

His Ile Ser Ser Ser Gly Asn Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  571
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 572

<400>  571

Glu Asp Pro Arg Leu Pro Gly Thr Thr Asp Phe Asp Tyr 
1               5                   10              


<210>  572
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  572

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Phe Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Ser Gly Asn Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Glu Asp Pro Arg Leu Pro Gly Thr Thr Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  573
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 576

<400>  573

Asp Tyr Tyr Met Thr 
1               5   


<210>  574
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 576

<400>  574

Tyr Ile Ser Ser Gly Gly Ser Thr Ile His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  575
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 576

<400>  575

Glu Asn Pro Arg Leu Pro Gly Thr Met Asp Phe Asp Tyr 
1               5                   10              


<210>  576
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  576

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Thr Trp Ile Arg Gln Gly Pro Gly Lys Gly Gln Glu Trp Ile 
        35                  40                  45              


Ser Tyr Ile Ser Ser Gly Gly Ser Thr Ile His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Pro Arg Leu Pro Gly Thr Met Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  577
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 580

<400>  577

Asp His Phe Met Ser 
1               5   


<210>  578
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 580

<400>  578

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  579
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 580

<400>  579

Glu Asp Pro Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  580
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  580

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 
            20                  25                  30          


Phe Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  581
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 584

<400>  581

Asn Tyr Trp Met Thr 
1               5   


<210>  582
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 584

<400>  582

His Ile Ser Ser Thr Gly Ser Thr Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  583
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 584

<400>  583

Glu Asp Pro Arg Leu Pro Gly Thr Met Asp Phe Asp Tyr 
1               5                   10              


<210>  584
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  584

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ser His Ile Ser Ser Thr Gly Ser Thr Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Leu Pro Gly Thr Met Asp Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  585
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 588

<400>  585

Asp Tyr Tyr Met Ser 
1               5   


<210>  586
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 588

<400>  586

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  587
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 588

<400>  587

Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  588
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  588

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  589
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 592

<400>  589

Asp Tyr Tyr Met Ser 
1               5   


<210>  590
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 592

<400>  590

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  591
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 592

<400>  591

Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  592
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  592

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  593
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  OF SEQ ID NO: 596

<400>  593

Asp Tyr Tyr Met Ser 
1               5   


<210>  594
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 596

<400>  594

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  595
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 596

<400>  595

Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  596
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  596

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  597
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 600

<400>  597

Asp Tyr Tyr Met Ser 
1               5   


<210>  598
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 600

<400>  598

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  599
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 600

<400>  599

Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  600
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  600

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  601
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 604

<400>  601

Asp Tyr Tyr Met Ser 
1               5   


<210>  602
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 604

<400>  602

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  603
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 604

<400>  603

Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  604
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  604

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  605
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 608

<400>  605

Asp Tyr Tyr Met Ser 
1               5   


<210>  606
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 608

<400>  606

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  607
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 608

<400>  607

Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  608
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  608

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  609
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 612

<400>  609

Asp Tyr Tyr Met Ser 
1               5   


<210>  610
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 612

<400>  610

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  611
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 612

<400>  611

Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  612
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  612

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  613
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 616

<400>  613

Asp Tyr Tyr Met Ser 
1               5   


<210>  614
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 616

<400>  614

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  615
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 616

<400>  615

Glu Asp Ala Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  616
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  616

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ala Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  617
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 620

<400>  617

Asp Tyr Tyr Met Ser 
1               5   


<210>  618
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 620

<400>  618

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  619
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 620

<400>  619

Glu Asp Pro Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  620
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  620

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  621
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 624

<400>  621

Asp Tyr Tyr Met Ser 
1               5   


<210>  622
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 624

<400>  622

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  623
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 624

<400>  623

Glu Asp Ala Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  624
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  624

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Ala Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  625
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 628

<400>  625

Asp Tyr Tyr Met Ser 
1               5   


<210>  626
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 628

<400>  626

Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  627
<211>  13
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(13)
<223>  CDR3 OF SEQ ID NO: 628

<400>  627

Glu Asp Pro Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn 
1               5                   10              


<210>  628
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH binding to CD137

<400>  628

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Pro Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  629
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  629
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acggaagtga gaaatactat      180

gaggactctg tggagggccg attcaccgtc tccagagaca acgccaagaa ctcggtatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  630
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  630
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agttattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaataa ctcgctgtat      240

ctacaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtgactccca ctacggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  631
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  631
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agttattgga tgacctggtt ccgccaggct      120

ccagggaggg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccgtc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaggggga      300

ttaggctacg gtgactccca ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  632
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  632
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgacctggtt ccgccaggct      120

ccaggggggg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccgtc tccagagaca acgccaagaa ctcactgtat      240

ctacaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaggggga      300

ttaggctacg gtgactccca ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  633
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  633
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgatctggtt ccgccaggct      120

ccaggaaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtggctccca ccacggtacg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  634
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  634
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagggggg      300

gaaggctata gcacctcgca ctacggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  635
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  635
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtggag cctctggatt cacctttagt agctattgga tgctctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acaccctgag agccgaggac acggctattt attattgtgc gagagggggt      300

gatggctaca gtgactccca cttcggtacg gacgtctggg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  636
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  636
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtggag cctctggatt cacctttagt agctattgga tgttctggtt ccgccaggct      120

ccaggagagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagaa ctctctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctattt attactgtgc gagaggaggt      300

gatggctaca gtgattccca ctacggtacg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  637
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  637
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgacctggtt ccgccaggct      120

ccaggggggg ggctggagtg ggtggccaac ataaaccaag atgggagtga gaagtactat      180

gtggactctg tggagggccg attcaccgtc tccagagaca acgccaagaa ctcactggat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaggggga      300

ttaggctacg gtgactccca ctacggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  638
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  638
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt gactattgga tgaactgggc ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaggagg atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccata tccagagaca acgccaagaa ctcaacgtat      240

ctgcaaatga acagcctgag agtcgaggac acggctgtgt attactgtgc gagaggaggg      300

gccgggtata gcatgtctca ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  639
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  639
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgaag cctctggatt cacctttagt gactattgga tgaactgggc ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaggagg atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccata tccagagaca acgccaagaa ctcaacgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaggaggg      300

gccgggtata gtatgtctca ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  640
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  640
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtggag cctctggatt cacctttagt agctattgga tgctctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acaccctgcg agccgaggac acggctattt attattgtgc gagagggggt      300

gatggctaca gtaactccca cttcggtacg gacgtctggg gccaagggac cacggtcacc      360

gtctcttca                                                              369


<210>  641
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  641
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggggggtc cctgagactc       60

tcctgtggag cctctggatt cacctttagt agctattgga tgttctggtt ccgccaggct      120

ccaggagagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagaa ctctctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctattt attactgtgc gagaggaggt      300

gatggctaca gtgattccca ctacggtacg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  642
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  642
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aattattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaggaag atggaagtga gaattactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagagggggg      300

gaaggctata gcacctcgca ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  643
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  643
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtggag cctctggatt cacctttagt acctattgga tgctctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtct      240

ctacaaatga acagcctgag agccgaggac acggcaactt attactgtgc gagaggaggt      300

gatggctaca gtgactccca cttcggtacg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  644
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  644
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgtag cctctggatt cacctttagt aactattgga tgatgtggtt ccgccaggct      120

ccaggaaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatacttt      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtagctctca ctacggtacg gacgtctggg gccaagggac cacggtcacc      360

gtctcttca                                                              369


<210>  645
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  645
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaggaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagggggg      300

gacagctatg gttacaggga ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  646
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  646
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt acccattgga tgaactgggc ccgccaggct      120

ccagggaagg agctggaatg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaacaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaagac acggctgtat attactgtgc gagagggggg      300

gttggctacg gtgactccca cttcggtatg gacgtctggg gcctagggac cacggtcacc      360

gtctcctca                                                              369


<210>  647
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  647
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgatctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaggaggt      300

gatgactaca gtaactccca ctacggtatg gacgtctcgg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  648
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  648
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgcagggccg attcaccatc tccagagaca atgccaataa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagggggg      300

tttggctacg gtgactccca ctacggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  649
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  649
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtggag cctctggatt cacctttagt agttattgga tgttctggtt ccgccaggct      120

ccaggaaagg agctggagtg ggtggccaat gttaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctattt attactgtgc gagaggaggt      300

gagggctaca gtgattccca ctacggtacg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  650
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  650
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaat ataaaggaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaggaa ctcactgtat      240

ctgcaaatga acagtctgag agccgaggac acggctgtgt attactgtgc gagagggggg      300

gagggctacg gtgactccca ctacggtatg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  651
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  651
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agttattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactttat      240

ctgcaaatga acagcctgac agccgaggac acggctgtgt attattgtgc gagagggggg      300

gagggctacg gtgacgacca ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  652
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  652
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagggggg      300

gagggctacg gtgactacca ctacggtttg gacgtctcgg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  653
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  653
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagggggg      300

gacagctatg gttacaggga ctacggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  654
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  654
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgtag cctctggatt cacctttagt acccattgga tgaactgggc ccgccaggct      120

ccagggaagg agctggaatg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaacaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaagac acggctgtat attactgtgc gagagggggg      300

gttggctacg gtgactccca cttcggtatg gacgtctggg gcctagggac cacggtcact      360

gtctcctca                                                              369


<210>  655
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  655
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtggag cctctggatt cacctttagt agttattgga tgctctggtt ccgccaggct      120

ccaggagagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg actcaccatc tccagagaca acgccaagaa cgctctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctattt attactgtgc gagaggaggt      300

gaaggctaca gtgattccca ccacggtacg gacgtctggg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  656
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  656
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagggggg      300

gacaactatg cttacaggga cttcggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  657
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  657
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtggag cctctggatt cacctttagt aattattgga tgttctggtt ccgccaggct      120

ccaggaaagg agctggagtg ggtggccaat gttaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctattt attactgtgc gagaggaggt      300

gagggctaca gtgattccca ctacggtacg gacgtctggg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  658
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  658
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagggggg      300

gaagagtatg ggagctcgca ctacggtatg gacgtctggg gcctggggac cacggtcact      360

gtctcctca                                                              369


<210>  659
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  659
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attattgtgc gagagggggg      300

gacagctatg gttacaggga ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  660
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  660
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctaagactc       60

tcctgtgcag cctctggatt cacctttagt agttattgga tgaactgggt ccgccagact      120

ccagggaagg ggctggagtg ggtggccaac ataaatcaaa atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaacatc tccagagaca acgccaagaa ctcactgtat      240

ctacaaatga gtagcctgag agccgaggac acggctgtgt attactgtgc gagagggggg      300

tttggctacg gtgattccca ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  661
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  661
gaggtgcagc tggtggagtc tgggggaggc ttggtccagg cgggggggtc cctaagactc       60

tcctgtgtag cctctggatt cacctttagt aattattgga tgacctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atgaaagtga ggaatactat      180

gtggactctg tgaagggccg tttcaccatc tccagagaca acgccaagaa ctcactgttt      240

ctgcaaatga acagcctgag agccgaggac acggctattt attactgtgc gagaggaggt      300

gatggctaca gtgactccca ctacggtacg gacgtctggg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  662
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  662
caggtgcagc tgcaggagtc ggggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtacag cctctggatt cacctttagt aattattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaggaag atggaagtga gaattactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagagggggg      300

gaaggctata gcacctcgca ctacggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcttca                                                              369


<210>  663
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  663
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac attaagcaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatgg acagcctgag agccgaggac acggctgttt attactgtgc gagagggggg      300

gagggctacg gtgaatccca ctacggtatg gacgtctcgg gccaagggac cacggtcacc      360

gtctcttca                                                              369


<210>  664
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  664
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt acctattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaacaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagggggg      300

gacagctatg gttacaggga ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  665
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  665
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt tactattgga tgatctggtt ccgccaggct      120

ccaggtgagg agctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcattatc tccagagaca acgccacgaa ctcactgttt      240

ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagaggaggt      300

gatggctaca gtaattccca cttcggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcttca                                                              369


<210>  666
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  666
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgatctggta ccgccaggct      120

ccaggtgagg agctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctattt attactgtgc gagaggaggt      300

gagggctaca gtgattccca ctacggtacg gacgtctggg gccaggggac cacggtcact      360

gtctcttca                                                              369


<210>  667
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  667
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg agctggagtg ggtggccaac ataaaccaag atgaaagtga aaaatactat      180

gttgactctg tgaagggccg tttcaccgtc tccagagaca acgccaagaa ctcactgttt      240

ctgcaaatga acagcctgag agccgacgac acggctgtat attactgtgc gagagggggg      300

tttggctacg gtgactccca cttcggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcttca                                                              369


<210>  668
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  668
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtggag cctctggatt cacctttagt aattattgga tgttctggtt ccgccaggct      120

ccaggaaagg agctggagtg ggtggccaat gttaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagacg acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctattt attactgtgc gagaggaggt      300

gagggctaca gtgattccca ctacggtacg gacgtctggg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  669
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  669
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtggag cctctggatt cacctttagt aattattgga tgttctggtt ccgccaggct      120

ccaggaaagg agctggagtg ggtggccaat gttaaccaaa atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctattt attactgtgc gagaggaggt      300

gagggctaca gtgattccca ctacggtacg gacgtctggg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  670
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  670
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagga ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctattt attattgtgc gagagggggg      300

gagggttacg gtgactccca ctacggtatg gacgtctcgg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  671
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  671
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgatctggta ccgccaggct      120

ccaggtgagg agctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccacgaa ctcactgttt      240

ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagaggaggt      300

gatggctaca gtaattccca ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  672
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  672
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt gactattgga tgatctggta ccgccaggct      120

ccaggtgagg agctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccacgaa ctcactgttt      240

ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagaggaggt      300

gatggctaca gtaattccca ctacggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  673
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  673
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aaatattgga tgatctgggt ccgccaggct      120

ccagaaaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatt tccagagaca atgtcaataa ctcattgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt actactgtgc gagaggaggt      300

gatgactaca gtaactccca ctacggtatg gacgtctcgg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  674
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  674
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgagctgggt ccgccaggct      120

ccagggaggg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagag ctcactgtat      240

ctgcaaatga acagccttag agccgaggac acggctgttt attactgtgc gagagggggg      300

gaagaatata gcagctccca ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  675
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  675
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtatag cctctggatt cagctttagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaattactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagggggg      300

gaagggtata gcacctcgca ctacggtatg gacgtctggg gccaagggac cgcggtcact      360

gtctcttca                                                              369


<210>  676
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  676
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  677
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  677
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtggag cctctggatt cacctttagt agctattgga tgctctggtt ccgccaggct      120

ccaggaaagg agctggagtg ggtggccaat gttaaccaag atggcagtga gaattactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatgc acagcctgag agccgaggac acggctgtat attactgtgc gagaggaggt      300

gaagactacg gtaactccca cttcggcatg gacgtctggg gccaagggac catggtcacc      360

gtctcctca                                                              369


<210>  678
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  678
gaggtgcagc tggtggagtc tgggggaggc ttggtgcagc ctggcagatc cctgagactc       60

tcttgtgcag cctctggatt cacctttagt aactattgga tgatctggta ccgccaggct      120

ccaggtgagg agctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccacgaa ctcactgttt      240

ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagaggaggt      300

gatggctaca gtaattccca ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  679
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  679
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgatctggta ccgccaggct      120

ccaggtgagg agctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccacgaa ctcactgttt      240

ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagaggaggt      300

gatggctaca gtaattccca ctacggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  680
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  680
gaggtgcagc tggtggagtc tgggggaggc ttggtccaga ttggggggtc cctgagactc       60

tcctgtgcag cctccggatt cacctttagt aaatattgga tgatctgggt ccgccaggct      120

ccagaaaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatt tccagagaca acgccaataa ctcactgttt      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt actactgtgc gagaggaggt      300

gatgactaca gtatctccca cttcggtatg gacgtctcgg gccaagggac cagggtcacc      360

gtctcctca                                                              369


<210>  681
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  681
gaggtgcagc tggtggagtc tgggggaggc ttggtccaga ttggggggtc cctgagactc       60

tcctgtgtag cctctggatt cacctttagt aaatattgga tgatctgggt ccgccaggct      120

ccagaaaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatt tccagagaca acgccaataa ttcattgtat      240

ctgcagatga acagcctgag agccgaggac acggctgtgt actactgtgc gagaggaggt      300

gatgactaca gtcactccca ctacggtatg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  682
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  682
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caactttagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg agctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgttt      240

ctgcaaatga acagcctgag agccgacgac acggctgtgt attactgtgc gagagggggg      300

tttggctacg gtgactccca ctacggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  683
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  683
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttggt agttattggc tgaattgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggcagtga gaattactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatgc acagcctgag agccgaggac acggctgtat attactgtgc gagaggaggt      300

gaagactacg gtaactccca cttcggcatg gacgtctggg gccaagggac catggtcact      360

gtctcttca                                                              369


<210>  684
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  684
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  685
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  685
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtacag cctctggatt cacctttagt gactattgga tgaactgggt ccgccaggct      120

ccaggtaagg ggctggagtg ggtggccaat ataaaggaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaggaa ctcactgtat      240

ctgcaaatga ccagcctgag agaagaagac acggctatgt attactgtgc gagagggggg      300

gagggctacg gtgacaacca ctacggtatg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  686
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  686
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttaga agctattgga tgaactgggt ccgccaggct      120

ccagggaagg aggcggaatg ggtggccaac ataaaccaag atggaagtga gaaatattat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagaa ctcactgttt      240

ctgcaaatga acagcctgag agacgaggac acggctgttt attactgtgc gagaggaggc      300

cccgactacg gtgacctcca ctacggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  687
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  687
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctaagactc       60

tcctgtgcag cctctggatt cacctttagt aggtattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagcg ggtggccaac ataaaccaag atggacgtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attattgtgc gagagggggg      300

gagggctacg gtgactacca ctacggtatg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  688
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  688
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cccgagactc       60

tcctgtgcag cctctggatt cacccttagt aactattgga tgatctggta ccgccaggct      120

ccaggtgaga agctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccacgaa ctcactgttt      240

ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagaggaggt      300

gatggctaca gtaattccca ctacggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  689
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  689
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgtag cctctggatt caacttcagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg agctggagtg ggtggccaac ataaaccaag atgaaagtga aaaatactat      180

gtagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgttt      240

ctgcaaatga acagcctgag agccgacgac acggctgtgt attactgtgc gagagggggg      300

tttggctacg gtgactccca cttcggtatg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  690
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  690
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caattttagt aactattgga tgaactgggt ccgtcaggct      120

ccagggaagg agctggagtg ggtggccaac ataaaccaag atgaaagtga aaaatactat      180

gtagactctg tgaagggccg attcaccatt ttcagagaca acgccaagaa ctcactgttt      240

ctgcaaatga acagcctgag agccgacgac acggctgtgt attactgtgc gagagggggg      300

tttggctacg gtgactccca cttcggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  691
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  691
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagtctc       60

tcctgtgcag cctctggatt cacctttaga agcttttgga tgaactgggt ccgccaggct      120

ccagggaagg aggcggaatg ggtggccaac ataaatcaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgttt      240

ctgcaaatga acagcctgag agccgaggac acggctgttt attactgtgc gagaggaggc      300

cccgactacg gtgacctcca ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  692
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  692
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttaga agctattgga tgaactgggt ccgccaggct      120

ccagggaagg aggcggaatg ggtggccaac ataaaccaag atggaagtga gaaatattat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgttt      240

ctgcaaatga acagcctgag agacgaggac acggctgttt attactgtgc gagaggaggc      300

cccgactacg gtgacctcca ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  693
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  693
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgatctggta ccgccaggct      120

ccaggtgagg agctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatgc acagcctgag agccgaggac acggctgtat attactgtgc gagaggaggt      300

gaagactacg gtaactccca ctacggcatg gacgtctggg gccaagggac catggtcacc      360

gtctcttca                                                              369


<210>  694
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  694
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagag ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtatcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  695
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  695
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaatcaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagag ctcactgtat      240

ctgcaaatga gtagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  696
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  696
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt aactattgga tgatctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga gaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagag ctcactgtat      240

ctgcaaatga gcaacctgag agccgaggac acggctgtat atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  697
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  697
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag ccactggatt caccttaagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgttt      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagaggggga      300

acaggctatg gttccgacca ctacggtatg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  698
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  698
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caattttagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg agctggagtg ggtggccaac ataaaccaag atggaagtga gaattactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgtcaagaa ctcactgttt      240

ctgcaaatga accgcctgag agccgacgac acggctgtgt attactgtgc gagagggggg      300

tttggctacg gtgactccca ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  699
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  699
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttggt aactattgga tgatctgggt ccgccaggct      120

ccaggcaagg agttggagtg gctggccaac ataaaccaaa atggaagtga gagatactat      180

gtggactctg tgcagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtat attactgtgc gagagggggt      300

gctgactaca gtaactccca ctacggtatg gacgtcagcg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  700
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  700
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaacaa ctcactgcat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  701
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  701
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttaga agttattgga tgaactgggt ccgccaggct      120

ccagggaaag aggcggaatg ggtggccaac ataaacccag atggaagtga gaaatactat      180

gtggactctg tgcagggccg acacaccatc tccagagaca acgccaagaa ctcactgttt      240

ctggaaatga acagcctgag agtcgaggac acggctcttt attactgtgc gagaggaggc      300

cccggctacg gtgacctcca ctacggtatg gacgtctggg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  702
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  702
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag ccactggatt caccttaagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaatcaag atggaagtga aaaatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagag ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcact      360

gtctcctca                                                              369


<210>  703
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  703
caggtgcagc tggtggagtc tgggggaggc ctggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcacc      360

gtctcttca                                                              369


<210>  704
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  704
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag ccactggatt caccttaagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcacc      360

gtctcttca                                                              369


<210>  705
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  705
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttaagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  706
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  706
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag ccactggatt caccttaagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  707
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  707
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag ccactggatt caccttaagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcaacca ctacggtttg gacgtctcgg gccaagggac cacggtcacc      360

gtctcttca                                                              369


<210>  708
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  708
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgtag cctctggatt caccttcagt gactactata tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaagcaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagag ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  709
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  709
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag ccactggatt caccttaagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagag ctcactgtat      240

ctgcaaatga gcaacctgag agccgaggac acggctgtat atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  710
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  710
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag ccactggatt caccttaagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatt tccagagaca acgccaagag ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  711
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  711
caggtgcagc tgcaggagtc ggggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag ccactggatt caccttaagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  712
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  712
caggtgcagc tggtggagtc tgggggaggc ctggtcaagc ctggggggtc cctgagactc       60

tcctgtgcag ccactggatt caccttaagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  713
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  713
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag ccactggatt caccttaagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaacaa ctcactgcat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  714
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  714
caggtgcagc tgggggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag ccactggatt caccttaagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tggagggccg attcaccatc tccagagaca acgccaagag ctcactgtat      240

ctgcaaatga gcaacctgag agccgaggac acggctgtat atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  715
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  715
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgaaactc       60

tcctgtgcag ccactggatt caccttaagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatt tccagagaca acgccaagag ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  716
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  716
caggtgcagc tgcaggagtc ggggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag ccactggatt caccttaagt aactattgga tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatc tccagaggca acgccaagaa ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  717
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  717
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttgat gattatggca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaccaag atggaagtga aagatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga gcagcctgag agccgaggac acggctgtgt atttctgtgc gagagggggg      300

gaaggctatg gtgtcgacca ctacggtttg gacgtctcgg gccaagggac cacggtcact      360

gtctcttca                                                              369


<210>  718
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  718
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acggaagtga gaaatactat      180

gaggactctg tggagggccg attcaccgtc tccagagaca acgccaagaa ctcggtatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  719
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  719
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccgtc tccagagaca acgccaagaa ctcggtatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  720
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  720
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acggaagtga gaaatactat      180

gaggactctg tgaagggccg attcaccgtc tccagagaca acgccaagaa ctcggtatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  721
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  721
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acggaagtga gaaatactat      180

gaggactctg tggagggccg attcaccatc tccagagaca acgccaagaa ctcggtatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  722
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  722
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acggaagtga gaaatactat      180

gaggactctg tggagggccg attcaccgtc tccagagaca acgccaagaa ctcgttatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  723
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  723
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcgttatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  724
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  724
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcgttatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  725
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  725
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acgaaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcgttatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gttggctaca gtatctccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  726
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  726
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttgggt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acgaaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcgttatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gagggctaca gtatctccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  727
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  727
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acgaaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcgttatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  728
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  728
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acgaaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcgttatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtatctccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  729
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  729
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag gcggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcgttatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  730
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  730
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag agggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcgttatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  731
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  731
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcgttatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gagggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  732
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  732
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcgttatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gttggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  733
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  733
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acgaaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcgttatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gttggctaca gtatctccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  734
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  734
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acgaaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcgttatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gagggctaca gtatctccca cttcggtgtg gacgtctggg gccaagggac cacggtcacc      360

gtctcctca                                                              369


<210>  735
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  735
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagagtc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtgatat catagactac      180

gcagactctg taaagggccg attcaccatc tccagggaca acgccaagaa ctctctgtat      240

ctgcagatga acaacctgag agccgaggac acggccgtgt atcactgtgc gagagaagat      300

tcccgtctaa ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  736
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  736
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagagtc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcgtac attagtggta gtggtgatat catagactat      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt atcactgtgc gaaagaagat      300

tcccgtatac ctggaactac ggactttgac aattggggcc agggaaccct ggtcactgtc      360

tcctca                                                                 366


<210>  737
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  737
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagagtc       60

tcctgtgcag cctctggatt caccttcagt gactactata tgagttggtt ccgccaggct      120

ccagggaagg ggctggagtg gatttcgtac attagtggta gtggtgatat catagactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt atcactgtgc gaaagaagat      300

tcccgtatac ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcttca                                                                 366


<210>  738
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  738
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagagtc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcgtac attagtggta gtggtgatgt cattgactat      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt atcactgtgc gaaagaagat      300

tcccgtatac ctggaactac ggactttgac aattggggcc agggaaccct ggtcactgtc      360

tcttca                                                                 366


<210>  739
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  739
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag tctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcgtac attagtggta gtggtgatat catagactat      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt atcactgtgc gaaagaagat      300

tcccgtatac ctggaactac ggactttgac aattggggcc agggaaccct ggtcactgtc      360

tcctca                                                                 366


<210>  740
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  740
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagagtc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcgtac attagtggta gtggtgatat catagactat      180

gcggactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt atcactgtgc gaaagaagat      300

tcccgtatac ctggaactac ggactttgac agttggggcc aagggacaat ggtcaccgtc      360

tcctca                                                                 366


<210>  741
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  741
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc caggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtactac catagactac      180

gcagactctg tgaagggccg cttcaccatc tccagggaca acgccaggaa ctcactatat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc cagagaagat      300

atcaggatga ctggaactac ggactttgac aactggggcc agggaaccct ggtcaccgtc      360

tcttca                                                                 366


<210>  742
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  742
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt cgccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtggta gtggaactac catagactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactatat      240

ctacaaatga acagcctgag agccgaggac acggccgtgt atcactgtgc gagagaagat      300

tcccgcatgc ctggaactac ggactttgac aactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  743
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  743
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactata tgacctggtt ccgccaggct      120

ccagggaagg gactggagtg gatttcatac attagtggta gtggtgatac catagactac      180

gcagagtctg tgaagggccg attcaccatc tccagggaca acgccaagaa ttcactgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtgt atcactgtgc gagagaagat      300

tcgcgtatag ccggaactac ggactttgac aactggggcc cgggaaccct ggtcactgtc      360

tcttca                                                                 366


<210>  744
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  744
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgacctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtaa catagattac      180

gcagactctg tgaagggccg attcaccatc tctagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

tcccgtttaa gtggaactac ggactttgac tactggggcc agggaaccct ggtcaccgtc      360

tcttca                                                                 366


<210>  745
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  745
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactata tgacctggtt ccgccaggct      120

ccagggaagg gactggagtg gatttcatac attagtggta gtggtgatac catagactac      180

gcagagtctg tgaagggccg attcaccatc tccagggaca acgccaagaa ttcactgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtgt atcactgtgc gagagaagat      300

tcgcgtatag ccggaactac ggactttgac aactggggcc cgggaaccct ggtcactgtc      360

tcctca                                                                 366


<210>  746
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  746
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtggta gtggtactac catagactac      180

gcagactctg tgaagggccg cttcaccatc tccagggaca acgccaggaa gtcactatat      240

ctgcagatga acagcctgag agccgaggac acggccgtct attactgtgc cagagaagat      300

atcaggatga ctggaactac ggactttgac cactggggcc aaggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  747
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  747
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtagta gtggtaatac catagactac      180

gcagactctg tgaagggccg cttcaccatc tccagggaca acgccaagaa ctcactttat      240

ctgcaaatga atagtctgag agccgaggac acggccgttt attactgtgc gagagaagat      300

cctcgtttac ctggaactac agattttgac tactggggcc agggaaccct ggtcactgtc      360

tcctca                                                                 366


<210>  748
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  748
gaggtgcagt tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactata tgacctggtt ccgccaggct      120

ccagggaagg gactggagtg gatttcatac attagtggta gtggtgatac catagactac      180

gcagagtctg tgaagggccg attcaccatc tccagggaca acgccaagaa ttcactgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtgt attactgtgc cagagaagat      300

atcaggatgc ctggaactac ggactttgac cactggggcc aaggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  749
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  749
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag tctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtggta gtggaactac catagactac      180

gcagactctg tgaagggccg cttcaccatc tccagggaca acgccaggaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc cagagaagat      300

atcaggatgc ctggaactac ggattttgac cactggggcc aaggaaccct ggtcactgtc      360

tcttca                                                                 366


<210>  750
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  750
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtagta gtgggagtac catagactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

cctcgtttaa ctggaactac agattttgac tactggggcc agggagccct ggtcactgtc      360

tcctca                                                                 366


<210>  751
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  751
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtac catatcctac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

cctcgtataa gtggaactac agattttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  752
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  752
caggtgcagc tgcaggagtc ggggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtagta gtggtaatac catagactac      180

gcagactctg tgaagggccg cttcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgttt attactgtgc gagagaagat      300

cctcgtttac ctggaactac agattttgac tactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  753
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  753
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta ctggtattac cacagactac      180

gcagactctg tgaagggccg cttcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

cctcgtttac ctggaacttc agaatttgac aactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  754
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  754
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtagta gtggtagtac catagattat      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtct attactgtgc gagagaagat      300

ccccgtatgc ctggaacttt tgactttgac aactggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  755
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  755
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt cgccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtggta gtggaactac catagactac      180

gcagactctg tgaagggccg cttcaccatc tccagggaca acgccaggaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc cagagaagat      300

atcaggatgc ctggaactac ggactttgac cactggggcc aaggaaccct ggtcactgtc      360

tcttca                                                                 366


<210>  756
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  756
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag tctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtggta gtggaactac catagactac      180

gcagactctg tgaagggccg cttcaccatc tccagggaca acgccaggga ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc cagagaagat      300

atcaggatgc ctggaactac ggattttgac cactggggcc aaggaaccct ggtcactgtc      360

tcttca                                                                 366


<210>  757
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  757
gaggtgcagc tggtggagtc tgggggaggc ttggtcacgc ctggagggtc cctgagactc       60

tcctgtgcag tctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtggta gtggaactac catagactac      180

gcagactctg tgaagggccg cttcaccatc tccagggaca acgccaggaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc cagagaagat      300

atcaggatgc ctggaactac ggattttgac cactggggcc aaggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  758
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  758
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag tctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtggta gtggaactac catagactac      180

gcagactctg tgaagggccg cttcaccatc tccagggaca acgccaggaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccatgt attactgtgc cagagaagat      300

atcaggatgc ctggaactac ggattttgac cactggggcc aaggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  759
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  759
gaggtgcagc tggtggagtc tgggggaggc ttggttaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt cgccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtggta gtggaactac catagactac      180

gcagactctg tgaaggaccg cttcaccatc tccagggaca acgccaggaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc cagagaagat      300

atcaggatgc ctggaactac ggactttgac cactggggcc aaggaaccct ggtcactgtc      360

tcttca                                                                 366


<210>  760
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  760
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtacag cctctggatt caccttcact gactattata tgagctggtt ccgccaggct      120

ccagggaagg gactggagtg ggtttcacac attagtagta gtggtactac aatagactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgacgac acggccgtat attactgtgc gagagaagat      300

atcaggatgc ctggaactac ggactttgac aactggggcc agggaaccct ggtcactgtc      360

tcctca                                                                 366


<210>  761
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  761
caggtgcagc tggtggagtc ggggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgacctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtac catttcctac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaacaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtat atcactgtgc gagagaagat      300

atacgtatga gtgggactac ggactttgac tactggggcc agggaaccct ggtcactgtc      360

tcctca                                                                 366


<210>  762
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  762
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt catcttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtagta gtggtagttc catagactac      180

gcagactctg tgaagggccg attcaccatt tcgagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

cctcgtttaa gtggaactat agattttgac tcctggggcc agggaaccct ggtcaccgtc      360

tcttca                                                                 366


<210>  763
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  763
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt cgccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attggtggta gtggaactac catagactac      180

gcagactctg tgaagggccg cttcaccatc tccagggaca acgccaggaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc cagagaagat      300

atcaggatgc ctggaactac ggactttgac cactggggcc aaggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  764
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  764
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtagta gtggtagtac catatactac      180

gcagactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

cctcgtgtgc ctggaactac gaactttgac tactggggcc agggaaccct ggtcactgtc      360

tcctca                                                                 366


<210>  765
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  765
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgacctggat gcgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggca gtggtagtac cattgactat      180

gcagactctg tgaagggccg attcacgatc tccagggaca acgccaagaa ctcactgtac      240

ctgcaaatga acagcctgag acccgaggac acggccgtgt attactgtgc gaaagaagat      300

ggccgtatac ctggaactac ggactttgac cactggggcc agggaaccct ggtcactgtc      360

tcttca                                                                 366


<210>  766
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  766
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cgccttcagt gactactaca tgagctggtt ccgccaggct      120

ccggggaagg ggctggagtg ggtttcacac attagtggta gtggaactac catagactac      180

gcagactctg tgaaggaccg cttcaccatc tccagggaca acgccaggaa ttcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc cagagaagat      300

atcaggatgc ctggaactac ggactttgac cactggggcc aaggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  767
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  767
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt ccccttcagt gactacttca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtagta gtggtaattc catagactac      180

gcagactctg tgaagggccg cttcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgttt attactgtgc gaaagaagat      300

cctcgtttac ctggaactac agattttgac tactggggcc agggaaccct ggtcactgtc      360

tcttca                                                                 366


<210>  768
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  768
caggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactcctaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacat attagtaatt ctggtagtac cataagctac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

cctcgtttac ctggaacttc agattttgac tactggggcc agggaaccct ggtcactgtc      360

tcttca                                                                 366


<210>  769
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  769
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtagta gtggtagttc catagactac      180

gcagactctg tgaagggccg attcaccatt tcgagggaca acgccaagaa ttcactgtat      240

ctgcaaatga acagcctgag agacgaggac acggccgtgt attactgtgc gagagaagat      300

cctcgtttaa gtggaactac agattttgac cagtggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  770
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  770
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtagta gtggtagtac catagactac      180

gcagagtctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

cctcgtatga ctggaactac agattttgac tactggggcc agggaaccct ggtcaccgtc      360

tcttca                                                                 366


<210>  771
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  771
caggtgcagc tgcaggagtc ggggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt aactacttca tgagttggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcacac attagtagta gtggtaatac catagactac      180

gcagactctg tgaagggccg cttcaccatc tccagggaca acgccaagaa ctcactttat      240

ctgcaaatgg atagtctgag agccgaggac acggccgttt attactgttc gagagaagat      300

cctcgtttac ctggaactac agattttgac tactggggcc agggaaccct ggtcactgtc      360

tcttca                                                                 366


<210>  772
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  772
gaggtgcagc tggtggagtc tgggggaggc gtggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt cactttcagt gactactaca tgacctggat ccgccagggt      120

ccagggaagg gacaggaatg gatttcatac attagtagtg gtggtagcac catacactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccaagaa ctcactgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaaaat      300

ccccgtttac ctggaactat ggactttgac tattggggcc agggaaccct ggtcactgtc      360

tcctca                                                                 366


<210>  773
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  773
caggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gaccacttca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtggccaac ataaaacaag atggaagtga gaaatactat      180

gtggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctcactgttt      240

ctgcaaatga acagcctgag agccgaggac acggctatgt attactgtgc gagagaggat      300

cctcgtttaa ctggaactac agattttgac aactggggcc agggaaccct ggtcactgtc      360

tcttca                                                                 366


<210>  774
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  774
gaggtgcagc tggtggagtc tgggggaggc ttggtccagg cgggggggtc cctaagactc       60

tcctgtgtag cctctggatt cacctttagt aattattgga tgacctggtt ccgccaggct      120

ccagggaggg ggctggagtg ggtttcacac attagtagta ctggatctac catagactac      180

gcagactctg tgaagggccg attcaccatc tccagggaca acgccgagaa ctcactatat      240

ttgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

ccccgtttac ctggaactat ggactttgac tattggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  775
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  775
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtgatat catagactac      180

gcagactctg taaagggccg attcaccatc tccagggaca acgccaagaa ctctctgtat      240

ctgcagatga acaacctgag agccgaggac acggccgtgt atcactgtgc gagagaagat      300

tcccgtctaa ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  776
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  776
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagagtc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtgatat catagactac      180

gcagactctg taaagggccg attcaccatc tccagggaca acgccaagaa ctctctgtat      240

ctgcagatga acaacctgag agccgaggac acggccgtgt atcactgtgc gagagaagat      300

tcccgtctaa ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  777
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  777
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagagtc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtgatat catagactac      180

gcagactctg taaagggccg attcaccatc tccagggaca acgccaagaa ctctctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtgt atcactgtgc gagagaagat      300

tcccgtctaa ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  778
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  778
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagagtc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtgatat catagactac      180

gcagactctg taaagggccg attcaccatc tccagggaca acgccaagaa ctctctgtat      240

ctgcagatga acaacctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

tcccgtctaa ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  779
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  779
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtgatat catagactac      180

gcagactctg taaagggccg attcaccatc tccagggaca acgccaagaa ctctctgtat      240

ctgcagatga acaacctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

tcccgtctaa ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  780
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  780
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtgatat catagactac      180

gcagactctg taaagggccg attcaccatc tccagggaca acgccaagaa ctctctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

tcccgtctaa ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  781
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  781
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtgatat catagactac      180

gcagactctg taaagggccg attcaccatc tccagggaca acgccaagaa ctctctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

tcccgtctaa ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  782
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  782
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtgatat catagactac      180

gcagactctg taaagggccg attcaccatc tccagggaca acgccaagaa ctctctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

gcccgtctaa ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  783
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  783
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtgatat catagactac      180

gcagactctg taaagggccg attcaccatc tccagggaca acgccaagaa ctctctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

ccccgtctaa ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  784
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  784
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtgatat catagactac      180

gcagactctg taaagggccg attcaccatc tccagggaca acgccaagaa ctctctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

gcccgtctaa ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  785
<211>  366
<212>  DNA
<213>  Homo sapiens

<400>  785
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtgatat catagactac      180

gcagactctg taaagggccg attcaccatc tccagggaca acgccaagaa ctctctgtat      240

ctgcagatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagaagat      300

ccccgtctaa ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctca                                                                 366


<210>  786
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  786

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  787
<211>  768
<212>  DNA
<213>  Homo sapiens

<400>  787
atgggaaaca gctgttacaa catagtagcc actctgttgc tggtcctcaa ctttgagagg       60

acaagatcat tgcaggatcc ttgtagtaac tgcccagctg gtacattctg tgataataac      120

aggaatcaga tttgcagtcc ctgtcctcca aatagtttct ccagcgcagg tggacaaagg      180

acctgtgaca tatgcaggca gtgtaaaggt gttttcagga ccaggaagga gtgttcctcc      240

accagcaatg cagagtgtga ctgcactcca gggtttcact gcctgggggc aggatgcagc      300

atgtgtgaac aggattgtaa acaaggtcaa gaactgacaa aaaaaggttg taaagactgt      360

tgctttggga catttaacga tcagaaacgt ggcatctgtc gaccctggac aaactgttct      420

ttggatggaa agtctgtgct tgtgaatggg acgaaggaga gggacgtggt ctgtggacca      480

tctccagccg acctctctcc gggagcatcc tctgtgaccc cgcctgcccc tgcgagagag      540

ccaggacact ctccgcagat catctccttc tttcttgcgc tgacgtcgac tgcgttgctc      600

ttcctgctgt tcttcctcac gctccgtttc tctgttgtta aacggggcag aaagaaactc      660

ctgtatatat tcaaacaacc atttatgaga ccagtacaaa ctactcaaga ggaagatggc      720

tgtagctgcc gatttccaga agaagaagaa ggaggatgtg aactgtga                   768


<210>  788
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Terminating residues of C- Terminal Domain of a VH domain

<400>  788

Val Thr Val Ser Ser 
1               5   


<210>  789
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hexa-His Tag

<400>  789

His His His His His His 
1               5       


<210>  790
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  790

Gly Gly Gly Gly Ser 
1               5   


<210>  791
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  791

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  792
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  792

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10  


<210>  793
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  793

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  794
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  794

Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210>  795
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  795

Gly Gly Ser Gly Ser Gly Ser Gly 
1               5               


<210>  796
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  796

Gly Gly Ser Gly Ser Gly 
1               5       


<210>  797
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Peptide Linker

<400>  797

Gly Gly Ser Gly 
1               


<210>  798
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bivalent molecule

<400>  798

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Phe Thr Phe Ser Ser His Trp Met Thr Trp Phe Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala His Ile Lys Glu Asp Gly 
        195                 200                 205             


Ser Glu Lys Tyr Tyr Glu Asp Ser Val Glu Gly Arg Phe Thr Val Ser 
    210                 215                 220                 


Arg Asp Asn Ala Lys Asn Ser Val Tyr Leu Gln Met Asn Ser Leu Arg 
225                 230                 235                 240 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp Gly Tyr 
                245                 250                 255     


Ser Asp Ser His Phe Gly Val Asp Val Trp Gly Gln Gly Thr Thr Val 
            260                 265                 270         


Thr Val Ser Ser 
        275     


<210>  799
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Bivalent Molecule of SEQ ID NO: 798

<400>  799
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acggaagtga gaaatactat      180

gaggactctg tggagggccg attcaccgtc tccagagaca acgccaagaa ctcggtatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcact      360

gtctcttcag gtggtggcgg ttcaggcgga ggtggctctg gaggtggagg ttcaggaggt      420

ggtggttctg gcggcggtgg atcgggtgga ggtggtagtg aggtgcagct ggtggagtct      480

gggggaggct tggtccagcc gggggggtcc ctgagactct cctgtgcagc ctctggattc      540

acctttagta gccattggat gacttggttc cgtcaggctc cagggaaggg gctggagtgg      600

gtggcccaca taaaggaaga cggaagtgag aaatactatg aggactctgt ggagggccga      660

ttcaccgtct ccagagacaa cgccaagaac tcggtatatc tgcaaatgaa cagtctgaga      720

gccgaagaca cggctgtgta ttactgtgcg agaggaggtg atggctacag tgactcccac      780

ttcggtgtgg acgtctgggg ccaagggacc acggtcactg tctcttca                   828


<210>  800
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bivalent Molecule

<400>  800

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala 
                165                 170                 175     


Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Gly Ser Gly Asp 
        195                 200                 205             


Ile Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Asn Leu Arg Ala 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr His Cys Ala Arg Glu Asp Ser Arg Leu Thr 
                245                 250                 255     


Gly Thr Thr Asp Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser 
        


<210>  801
<211>  822
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Bivalent Molecule of Seq ID NO; 800

<400>  801
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagagtc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtgatat catagactac      180

gcagactctg taaagggccg attcaccatc tccagggaca acgccaagaa ctctctgtat      240

ctgcagatga acaacctgag agccgaggac acggccgtgt atcactgtgc gagagaagat      300

tcccgtctaa ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctcaggtg gtggcggttc aggcggaggt ggctctggag gtggaggttc aggaggtggt      420

ggttctggcg gcggtggatc gggtggaggt ggtagtgagg tgcagctggt ggagtctggg      480

ggaggcttgg tcaagcctgg agggtccctg agagtctcct gtgcagcctc tggattcacc      540

ttcagtgact actacatgag ctggttccgc caggctccag ggaaggggct ggagtgggtt      600

tcatacatta gtggtagtgg tgatatcata gactacgcag actctgtaaa gggccgattc      660

accatctcca gggacaacgc caagaactct ctgtatctgc agatgaacaa cctgagagcc      720

gaggacacgg ccgtgtatca ctgtgcgaga gaagattccc gtctaactgg aactacggac      780

tttgacaatt ggggccaggg aaccctggtc accgtctcct ca                         822


<210>  802
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trivalent molecule

<400>  802

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
145                 150                 155                 160 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                165                 170                 175     


Ala Ser Gly Phe Thr Phe Ser Ser His Trp Met Thr Trp Phe Arg Gln 
            180                 185                 190         


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala His Ile Lys Glu Asp Gly 
        195                 200                 205             


Ser Glu Lys Tyr Tyr Glu Asp Ser Val Glu Gly Arg Phe Thr Val Ser 
    210                 215                 220                 


Arg Asp Asn Ala Lys Asn Ser Val Tyr Leu Gln Met Asn Ser Leu Arg 
225                 230                 235                 240 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Asp Gly Tyr 
                245                 250                 255     


Ser Asp Ser His Phe Gly Val Asp Val Trp Gly Gln Gly Thr Thr Val 
            260                 265                 270         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
305                 310                 315                 320 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
                325                 330                 335     


Ser His Trp Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            340                 345                 350         


Trp Val Ala His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp 
        355                 360                 365             


Ser Val Glu Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser 
    370                 375                 380                 


Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
385                 390                 395                 400 


Tyr Cys Ala Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val 
                405                 410                 415     


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            420                 425                 


<210>  803
<211>  1287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding the trivalent molecule of Seq ID NO: 802

<400>  803
gaggtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagt agccattgga tgacttggtt ccgtcaggct      120

ccagggaagg ggctggagtg ggtggcccac ataaaggaag acggaagtga gaaatactat      180

gaggactctg tggagggccg attcaccgtc tccagagaca acgccaagaa ctcggtatat      240

ctgcaaatga acagtctgag agccgaagac acggctgtgt attactgtgc gagaggaggt      300

gatggctaca gtgactccca cttcggtgtg gacgtctggg gccaagggac cacggtcact      360

gtctcttcag gtggtggcgg ttcaggcgga ggtggctctg gaggtggagg ttcaggaggt      420

ggtggttctg gcggcggtgg atcgggtgga ggtggtagtg aggtgcagct ggtggagtct      480

gggggaggct tggtccagcc gggggggtcc ctgagactct cctgtgcagc ctctggattc      540

acctttagta gccattggat gacttggttc cgtcaggctc cagggaaggg gctggagtgg      600

gtggcccaca taaaggaaga cggaagtgag aaatactatg aggactctgt ggagggccga      660

ttcaccgtct ccagagacaa cgccaagaac tcggtatatc tgcaaatgaa cagtctgaga      720

gccgaagaca cggctgtgta ttactgtgcg agaggaggtg atggctacag tgactcccac      780

ttcggtgtgg acgtctgggg ccaagggacc acggtcactg tctcttcagg tggtggcggt      840

tcaggcggag gtggctctgg aggtggaggt tcaggaggtg gtggttctgg cggcggtgga      900

tcgggtggag gtggtagtga ggtgcagctg gtggagtctg ggggaggctt ggtccagccg      960

ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttagtag ccattggatg     1020

acttggttcc gtcaggctcc agggaagggg ctggagtggg tggcccacat aaaggaagac     1080

ggaagtgaga aatactatga ggactctgtg gagggccgat tcaccgtctc cagagacaac     1140

gccaagaact cggtatatct gcaaatgaac agtctgagag ccgaagacac ggctgtgtat     1200

tactgtgcga gaggaggtga tggctacagt gactcccact tcggtgtgga cgtctggggc     1260

caagggacca cggtcactgt ctcttca                                         1287


<210>  804
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trivalent molecule

<400>  804

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
145                 150                 155                 160 


Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg Val Ser Cys Ala Ala 
                165                 170                 175     


Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser Trp Phe Arg Gln Ala 
            180                 185                 190         


Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile Ser Gly Ser Gly Asp 
        195                 200                 205             


Ile Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    210                 215                 220                 


Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Asn Leu Arg Ala 
225                 230                 235                 240 


Glu Asp Thr Ala Val Tyr His Cys Ala Arg Glu Asp Ser Arg Leu Thr 
                245                 250                 255     


Gly Thr Thr Asp Phe Asp Asn Trp Gly Gln Gly Thr Leu Val Thr Val 
            260                 265                 270         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
305                 310                 315                 320 


Ser Leu Arg Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
                325                 330                 335     


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            340                 345                 350         


Ser Tyr Ile Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val 
        355                 360                 365             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
    370                 375                 380                 


Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys 
385                 390                 395                 400 


Ala Arg Glu Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp 
                405                 410                 415     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            420                 425     


<210>  805
<211>  1278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding trivalent molecule of seq ID No: 804

<400>  805
gaggtgcagc tggtggagtc tgggggaggc ttggtcaagc ctggagggtc cctgagagtc       60

tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggtt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcatac attagtggta gtggtgatat catagactac      180

gcagactctg taaagggccg attcaccatc tccagggaca acgccaagaa ctctctgtat      240

ctgcagatga acaacctgag agccgaggac acggccgtgt atcactgtgc gagagaagat      300

tcccgtctaa ctggaactac ggactttgac aattggggcc agggaaccct ggtcaccgtc      360

tcctcaggtg gtggcggttc aggcggaggt ggctctggag gtggaggttc aggaggtggt      420

ggttctggcg gcggtggatc gggtggaggt ggtagtgagg tgcagctggt ggagtctggg      480

ggaggcttgg tcaagcctgg agggtccctg agagtctcct gtgcagcctc tggattcacc      540

ttcagtgact actacatgag ctggttccgc caggctccag ggaaggggct ggagtgggtt      600

tcatacatta gtggtagtgg tgatatcata gactacgcag actctgtaaa gggccgattc      660

accatctcca gggacaacgc caagaactct ctgtatctgc agatgaacaa cctgagagcc      720

gaggacacgg ccgtgtatca ctgtgcgaga gaagattccc gtctaactgg aactacggac      780

tttgacaatt ggggccaggg aaccctggtc accgtctcct caggtggtgg cggttcaggc      840

ggaggtggct ctggaggtgg aggttcagga ggtggtggtt ctggcggcgg tggatcgggt      900

ggaggtggta gtgaggtgca gctggtggag tctgggggag gcttggtcaa gcctggaggg      960

tccctgagag tctcctgtgc agcctctgga ttcaccttca gtgactacta catgagctgg     1020

ttccgccagg ctccagggaa ggggctggag tgggtttcat acattagtgg tagtggtgat     1080

atcatagact acgcagactc tgtaaagggc cgattcacca tctccaggga caacgccaag     1140

aactctctgt atctgcagat gaacaacctg agagccgagg acacggccgt gtatcactgt     1200

gcgagagaag attcccgtct aactggaact acggactttg acaattgggg ccagggaacc     1260

ctggtcaccg tctcctca                                                   1278


<210>  806
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bivalent molecule

<400>  806

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Ala Trp Gly Leu Arg Leu Gly Glu Ser Ser Ser Tyr 
            100                 105                 110         


Asp Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His Trp Met Thr 
            180                 185                 190         


Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala His Ile 
        195                 200                 205             


Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val Glu Gly Arg 
    210                 215                 220                 


Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
                245                 250                 255     


Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val Trp Gly Gln 
            260                 265                 270         


Gly Thr Thr Val Thr Val Ser Ser 
        275                 280 


<210>  807
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding the bivalent molecule of Seq ID No 806

<400>  807
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt ggctatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcatat atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagatccg      300

gcctggggat tacgtttggg ggagtcatcg tcctatgatt ttgatatctg gggccaaggg      360

acaatggtca ccgtctcctc aggtggtggc ggttcaggcg gaggtggctc tggaggtgga      420

ggttcaggag gtggtggttc tggcggcggt ggatcgggtg gaggtggtag tgaggtgcag      480

ctggtggagt ctgggggagg cttggtccag ccgggggggt ccctgagact ctcctgtgca      540

gcctctggat tcacctttag tagccattgg atgacttggt tccgtcaggc tccagggaag      600

gggctggagt gggtggccca cataaaggaa gacggaagtg agaaatacta tgaggactct      660

gtggagggcc gattcaccgt ctccagagac aacgccaaga actcggtata tctgcaaatg      720

aacagtctga gagccgaaga cacggctgtg tattactgtg cgagaggagg tgatggctac      780

agtgactccc acttcggtgt ggacgtctgg ggccaaggga ccacggtcac tgtctcttca      840


<210>  808
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bivalent molecule

<400>  808

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Ala Trp Gly Leu Arg Leu Gly Glu Ser Ser Ser Tyr 
            100                 105                 110         


Asp Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser 
            180                 185                 190         


Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile 
        195                 200                 205             


Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys Ala Arg Glu 
                245                 250                 255     


Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp Gly Gln Gly 
            260                 265                 270         


Thr Leu Val Thr Val Ser Ser 
        275                 


<210>  809
<211>  837
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding bivalent molecule of Seq ID NO 808

<400>  809
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt ggctatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcatat atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagatccg      300

gcctggggat tacgtttggg ggagtcatcg tcctatgatt ttgatatctg gggccaaggg      360

acaatggtca ccgtctcctc aggtggtggc ggttcaggcg gaggtggctc tggaggtgga      420

ggttcaggag gtggtggttc tggcggcggt ggatcgggtg gaggtggtag tgaggtgcag      480

ctggtggagt ctgggggagg cttggtcaag cctggagggt ccctgagagt ctcctgtgca      540

gcctctggat tcaccttcag tgactactac atgagctggt tccgccaggc tccagggaag      600

gggctggagt gggtttcata cattagtggt agtggtgata tcatagacta cgcagactct      660

gtaaagggcc gattcaccat ctccagggac aacgccaaga actctctgta tctgcagatg      720

aacaacctga gagccgagga cacggccgtg tatcactgtg cgagagaaga ttcccgtcta      780

actggaacta cggactttga caattggggc cagggaaccc tggtcaccgt ctcctca         837


<210>  810
<211>  266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bivalent molecule

<400>  810

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His Trp 
                165                 170                 175     


Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
            180                 185                 190         


His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val Glu 
        195                 200                 205             


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
            260                 265     


<210>  811
<211>  798
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding the bivalent molecule of Seq ID NO: 810

<400>  811
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attggtgaga atgatggtac cacagactac      180

gcagacgccg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctcag gtggtggcgg ttcaggcgga      360

ggtggctctg gaggtggagg ttcaggaggt ggtggttctg gcggcggtgg atcgggtgga      420

ggtggtagtg aggtgcagct ggtggagtct gggggaggct tggtccagcc gggggggtcc      480

ctgagactct cctgtgcagc ctctggattc acctttagta gccattggat gacttggttc      540

cgtcaggctc cagggaaggg gctggagtgg gtggcccaca taaaggaaga cggaagtgag      600

aaatactatg aggactctgt ggagggccga ttcaccgtct ccagagacaa cgccaagaac      660

tcggtatatc tgcaaatgaa cagtctgaga gccgaagaca cggctgtgta ttactgtgcg      720

agaggaggtg atggctacag tgactcccac ttcggtgtgg acgtctgggg ccaagggacc      780

acggtcactg tctcttca                                                    798


<210>  812
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 of SEQ ID NO: 815

<400>  812

Ser Tyr Ala Met Ser 
1               5   


<210>  813
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 815

<400>  813

Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  814
<211>  4
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(4)
<223>  CDR3 OF SEQ ID NO: 815

<400>  814

Asp Gly Val His 
1               


<210>  815
<211>  113
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(113)
<223>  VH binding to PSMA

<400>  815

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  816
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  816

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Asp Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  817
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  817

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Asp Asn Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  818
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  818

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Ala Asp Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  819
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  819

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Asp Val Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  820
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  820

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Ala Phe Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  821
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  821

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  822
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  822

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  823
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  823

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Ala Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  824
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  824

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Ala Tyr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  825
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  825

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Ala Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  826
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  826
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgcca tgagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attggtgaga atgatggtac cacagactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagag tatgctgtat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctca                             339


<210>  827
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  827
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attggtgaga ataacgctac cacagactac      180

gcagacttcg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctca                             339


<210>  828
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  828
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attggtgaga atgatggtac cacagactac      180

gcagacgccg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctca                             339


<210>  829
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  829
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attggtgaga atgatggtac cacagactac      180

gcagccgacg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctca                             339


<210>  830
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  830
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attggtgaga atgatggtac cacagactac      180

gcagacgtcg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctca                             339


<210>  831
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  831
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attggtgaga atgatggtac cacagactac      180

gcagccttcg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctca                             339


<210>  832
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  832
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attggtgaga atgatggtac cacagactac      180

gcagacaccg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctca                             339


<210>  833
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  833
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attggtgaga atgatggtac cacagactac      180

gcagacgccg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctca                             339


<210>  834
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  834
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attggtgaga atgatggtac cacagactac      180

gcagcctccg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctca                             339


<210>  835
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  835
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attggtgaga atgatggtac cacagactac      180

gcagcctacg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctca                             339


<210>  836
<211>  339
<212>  DNA
<213>  Homo sapiens

<400>  836
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attggtgaga atgatggtac cacagactac      180

gcagccaccg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctca                             339


<210>  837
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 840

<400>  837

Gly Tyr Gly Met His 
1               5   


<210>  838
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 of Seq ID NO: 840

<400>  838

Tyr Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  839
<211>  18
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(18)
<223>  CDR3 of SEQ ID NO. 840

<400>  839

Asp Pro Ala Trp Gly Leu Arg Leu Gly Glu Ser Ser Ser Tyr Asp Phe 
1               5                   10                  15      


Asp Ile 
        


<210>  840
<211>  127
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(127)
<223>  VH domain binding to PSMA

<400>  840

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Ala Trp Gly Leu Arg Leu Gly Glu Ser Ser Ser Tyr 
            100                 105                 110         


Asp Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125         


<210>  841
<211>  381
<212>  DNA
<213>  Homo sapiens

<400>  841
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt ggctatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcatat atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagatccg      300

gcctggggat tacgtttggg ggagtcatcg tcctatgatt ttgatatctg gggccaaggg      360

acaatggtca ctgtctcttc a                                                381


<210>  842
<211>  749
<212>  PRT
<213>  Homo sapiens

<400>  842

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Asp Ala Gln Lys Leu 
    290                 295                 300                 


Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg Gly 
305                 310                 315                 320 


Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn Phe 
                325                 330                 335     


Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val Thr 
            340                 345                 350         


Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro Asp 
        355                 360                 365             


Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly Gly 
    370                 375                 380                 


Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg Ser 
385                 390                 395                 400 


Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile Leu 
                405                 410                 415     


Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr Glu 
            420                 425                 430         


Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala Tyr 
        435                 440                 445             


Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val Asp 
    450                 455                 460                 


Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu Leu 
465                 470                 475                 480 


Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser Trp 
                485                 490                 495     


Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile Ser 
            500                 505                 510         


Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu Gly 
        515                 520                 525             


Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn Lys 
    530                 535                 540                 


Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu Leu 
545                 550                 555                 560 


Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val Ala 
                565                 570                 575     


Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val Leu 
            580                 585                 590         


Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala Asp 
        595                 600                 605             


Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr Tyr 
    610                 615                 620                 


Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr Glu 
625                 630                 635                 640 


Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser Asn 
                645                 650                 655     


Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu Arg 
            660                 665                 670         


Ala Phe Ile Asp Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg His 
        675                 680                 685             


Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser Phe 
    690                 695                 700                 


Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val Asp Pro 
705                 710                 715                 720 


Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala Phe 
                725                 730                 735     


Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 


<210>  843
<211>  1293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding the trvialent molecule in seq ID NO: 844

<400>  843
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt ggctatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcatat atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagatccg      300

gcctggggat tacgtttggg ggagtcatcg tcctatgatt ttgatatctg gggccaaggg      360

acaatggtca ccgtctcctc aggtggtggc ggttcaggcg gaggtggctc tggaggtgga      420

ggttcaggag gtggtggttc tggcggcggt ggatcgggtg gaggtggtag tgaggtgcag      480

ctggtggagt ctgggggagg cttggtccag ccgggggggt ccctgagact ctcctgtgca      540

gcctctggat tcacctttag tagccattgg atgacttggt tccgtcaggc tccagggaag      600

gggctggagt gggtggccca cataaaggaa gacggaagtg agaaatacta tgaggactct      660

gtggagggcc gattcaccgt ctccagagac aacgccaaga actcggtata tctgcaaatg      720

aacagtctga gagccgaaga cacggctgtg tattactgtg cgagaggagg tgatggctac      780

agtgactccc acttcggtgt ggacgtctgg ggccaaggga ccacggtcac tgtctcttca      840

ggtggtggcg gttcaggcgg aggtggctct ggaggtggag gttcaggagg tggtggttct      900

ggcggcggtg gatcgggtgg aggtggtagt caggtgcagc tggtggagtc tgggggaggc      960

ttggtacagc cgggggggtc cctgagactc tcctgtgcag cctctggatt cacctttagt     1020

agttatgcca tgagctgggt ccgccaggct ccagggaagg ggctggagtg ggtcgcaact     1080

attagtgata gtggtagtag tgcagactac gcagattccg tgaagggacg gttcaccatc     1140

tccagagaca actccaagaa cacgctgtat cttcaaatga acagcctgag agctgaagac     1200

acggccgtgt attactgtgc gagaggccgg tataactgga acccccgagc tttgggtatc     1260

tggggccaag ggacaatggt caccgtctcc tca                                  1293


<210>  844
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  trivalent molecule

<400>  844

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Ala Trp Gly Leu Arg Leu Gly Glu Ser Ser Ser Tyr 
            100                 105                 110         


Asp Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His Trp Met Thr 
            180                 185                 190         


Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala His Ile 
        195                 200                 205             


Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val Glu Gly Arg 
    210                 215                 220                 


Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
                245                 250                 255     


Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val Trp Gly Gln 
            260                 265                 270         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
305                 310                 315                 320 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                325                 330                 335     


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
            340                 345                 350         


Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Asp Ser Gly Ser Ser Ala 
        355                 360                 365             


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    370                 375                 380                 


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
385                 390                 395                 400 


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Tyr Asn Trp Asn Pro Arg 
                405                 410                 415     


Ala Leu Gly Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
            420                 425                 430     


<210>  845
<211>  1290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding trivalent molecule of Seq ID NO: 846

<400>  845
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt ggctatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcatat atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagatccg      300

gcctggggat tacgtttggg ggagtcatcg tcctatgatt ttgatatctg gggccaaggg      360

acaatggtca ccgtctcctc aggtggtggc ggttcaggcg gaggtggctc tggaggtgga      420

ggttcaggag gtggtggttc tggcggcggt ggatcgggtg gaggtggtag tgaggtgcag      480

ctggtggagt ctgggggagg cttggtcaag cctggagggt ccctgagagt ctcctgtgca      540

gcctctggat tcaccttcag tgactactac atgagctggt tccgccaggc tccagggaag      600

gggctggagt gggtttcata cattagtggt agtggtgata tcatagacta cgcagactct      660

gtaaagggcc gattcaccat ctccagggac aacgccaaga actctctgta tctgcagatg      720

aacaacctga gagccgagga cacggccgtg tatcactgtg cgagagaaga ttcccgtcta      780

actggaacta cggactttga caattggggc cagggaaccc tggtcaccgt ctcctcaggt      840

ggtggcggtt caggcggagg tggctctgga ggtggaggtt caggaggtgg tggttctggc      900

ggcggtggat cgggtggagg tggtagtcag gtgcagctgg tggagtctgg gggaggcttg      960

gtacagccgg gggggtccct gagactctcc tgtgcagcct ctggattcac ctttagtagt     1020

tatgccatga gctgggtccg ccaggctcca gggaaggggc tggagtgggt cgcaactatt     1080

agtgatagtg gtagtagtgc agactacgca gattccgtga agggacggtt caccatctcc     1140

agagacaact ccaagaacac gctgtatctt caaatgaaca gcctgagagc tgaagacacg     1200

gccgtgtatt actgtgcgag aggccggtat aactggaacc cccgagcttt gggtatctgg     1260

ggccaaggga caatggtcac cgtctcctca                                      1290


<210>  846
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trivalent Molecule

<400>  846

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Ala Trp Gly Leu Arg Leu Gly Glu Ser Ser Ser Tyr 
            100                 105                 110         


Asp Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ser 
            180                 185                 190         


Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr Ile 
        195                 200                 205             


Ser Gly Ser Gly Asp Ile Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys Ala Arg Glu 
                245                 250                 255     


Asp Ser Arg Leu Thr Gly Thr Thr Asp Phe Asp Asn Trp Gly Gln Gly 
            260                 265                 270         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    290                 295                 300                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
305                 310                 315                 320 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
                325                 330                 335     


Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
            340                 345                 350         


Gly Leu Glu Trp Val Ala Thr Ile Ser Asp Ser Gly Ser Ser Ala Asp 
        355                 360                 365             


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
    370                 375                 380                 


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
385                 390                 395                 400 


Ala Val Tyr Tyr Cys Ala Arg Gly Arg Tyr Asn Trp Asn Pro Arg Ala 
                405                 410                 415     


Leu Gly Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
            420                 425                 430 


<210>  847
<211>  1251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding trivalent molecule in Seq ID NO: 848

<400>  847
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attggtgaga atgatggtac cacagactac      180

gcagacgccg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctcag gtggtggcgg ttcaggcgga      360

ggtggctctg gaggtggagg ttcaggaggt ggtggttctg gcggcggtgg atcgggtgga      420

ggtggtagtg aggtgcagct ggtggagtct gggggaggct tggtccagcc gggggggtcc      480

ctgagactct cctgtgcagc ctctggattc acctttagta gccattggat gacttggttc      540

cgtcaggctc cagggaaggg gctggagtgg gtggcccaca taaaggaaga cggaagtgag      600

aaatactatg aggactctgt ggagggccga ttcaccgtct ccagagacaa cgccaagaac      660

tcggtatatc tgcaaatgaa cagtctgaga gccgaagaca cggctgtgta ttactgtgcg      720

agaggaggtg atggctacag tgactcccac ttcggtgtgg acgtctgggg ccaagggacc      780

acggtcactg tctcttcagg tggtggcggt tcaggcggag gtggctctgg aggtggaggt      840

tcaggaggtg gtggttctgg cggcggtgga tcgggtggag gtggtagtca ggtgcagctg      900

gtggagtctg ggggaggctt ggtacagccg ggggggtccc tgagactctc ctgtgcagcc      960

tctggattca cctttagtag ttatgccatg agctgggtcc gccaggctcc agggaagggg     1020

ctggagtggg tcgcaactat tagtgatagt ggtagtagtg cagactacgc agattccgtg     1080

aagggacggt tcaccatctc cagagacaac tccaagaaca cgctgtatct tcaaatgaac     1140

agcctgagag ctgaagacac ggccgtgtat tactgtgcga gaggccggta taactggaac     1200

ccccgagctt tgggtatctg gggccaaggg acaatggtca ccgtctcctc a              1251


<210>  848
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trivalent Molecule

<400>  848

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His Trp 
                165                 170                 175     


Met Thr Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
            180                 185                 190         


His Ile Lys Glu Asp Gly Ser Glu Lys Tyr Tyr Glu Asp Ser Val Glu 
        195                 200                 205             


Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Val Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Gly Asp Gly Tyr Ser Asp Ser His Phe Gly Val Asp Val Trp 
                245                 250                 255     


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly 
    290                 295                 300                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
305                 310                 315                 320 


Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala 
                325                 330                 335     


Pro Gly Lys Gly Leu Glu Trp Val Ala Thr Ile Ser Asp Ser Gly Ser 
            340                 345                 350         


Ser Ala Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Arg Tyr Asn Trp Asn 
385                 390                 395                 400 


Pro Arg Ala Leu Gly Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
                405                 410                 415     


Ser 
    


<210>  849
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 852

<400>  849

Asn Tyr Trp Met Asn 
1               5   


<210>  850
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 852

<400>  850

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  851
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 852

<400>  851

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  852
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  852

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  853
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO:856

<400>  853

Asn Tyr Trp Met Asn 
1               5   


<210>  854
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 856

<400>  854

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  855
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 856

<400>  855

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  856
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  856

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  857
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 860

<400>  857

Asn Tyr Trp Met Asn 
1               5   


<210>  858
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 860

<400>  858

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  859
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 860

<400>  859

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  860
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  860

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  861
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 864

<400>  861

Asn Tyr Trp Met Asn 
1               5   


<210>  862
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 864

<400>  862

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  863
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 864

<400>  863

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  864
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  864

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  865
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 868

<400>  865

Asn Tyr Trp Met Asn 
1               5   


<210>  866
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 868

<400>  866

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  867
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 868

<400>  867

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  868
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  868

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  869
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 872

<400>  869

Asn Tyr Trp Met Asn 
1               5   


<210>  870
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 872

<400>  870

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  871
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 872

<400>  871

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  872
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  872

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  873
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 876

<400>  873

Asn Tyr Trp Met Asn 
1               5   


<210>  874
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 876

<400>  874

Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  875
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 876

<400>  875

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  876
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  876

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  877
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  CDR1 OF SEQ ID NO: 880

<400>  877

Asn Tyr Trp Met Asn 
1               5   


<210>  878
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  CDR2 OF SEQ ID NO: 880

<400>  878

Asn Ile Asn Gln Asp Glu Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  879
<211>  14
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  CDR3 OF SEQ ID NO: 880

<400>  879

Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
1               5                   10                  


<210>  880
<211>  123
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(123)
<223>  VH binding to CD137

<400>  880

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asn Ile Asn Gln Asp Glu Ser Glu Arg Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val 
            100                 105                 110         


Ser Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  881
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  881
gaggtgcaat tagtcgaatc ggggggtgga ctggttcagc cgggaggtag cctgcgcctg       60

tcctgtgccg catctggttt tacattaagt aactactgga tgaattgggt tcgtcaagcg      120

cctggaaagg gcttagagtg ggtggctaat attaaccagg acgggtcaga gcgctactat      180

gtggattcag taaaaggtcg cttcactatc agccgcgata atgctaaaaa ttcgctgtac      240

cttcagatgt catcacttcg tgcagaggat acagctgtgt atttctgcgc gcgtggaggc      300

gaggggtacg gggtagacca ctatgggttg gatgtctcgg gacaaggcac gaccgtcact      360

gtcagtagc                                                              369


<210>  882
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  882
gaggtccagt tggttgagtc cggcggcggc ttggtccaac caggggggtc gcttcgctta       60

tcttgcgctg ccacagggtt taccctgagc aactactgga tgaactgggt gcgccaagcg      120

cctgggaagg ggttagagtg ggtcgccaac atcaaccaag acggttcgga gcgttactat      180

gtcgacagcg tgaagggccg tttcacgatc tcccgcgata acgctaagaa ctccctgtat      240

ttgcaaatga atagccttcg tgcggaggat actgcggttt atttctgtgc tcgtggcggt      300

gaaggatatg gggttgacca ttatgggttg gatgtctccg ggcaagggac aacggtgacc      360

gtgtcatcc                                                              369


<210>  883
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  883
gaggttcaac ttgttgaatc gggtggcgga ttagtacaac ccggcggctc gctgcgttta       60

tcgtgtgcgg caaccggatt tactttatca aactattgga tgaattgggt gcgccaggct      120

ccagggaaag gtctggaatg ggtagcgaat atcaaccaag acggctcaga acgctactac      180

gtggactccg taaaaggtcg tttcaccatc tctcgtgaca atgctaaaaa ttctttgtat      240

ttgcaaatga gttcacttcg tgctgaggat actgcggtct attactgtgc tcgcgggggg      300

gaaggctacg gagtagacca ctacgggttg gatgtttctg gacagggaac gacggttact      360

gtaagcagc                                                              369


<210>  884
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  884
gaggttcagt tagttgagtc cggcggggga ttagttcaac ctggcggaag ccttcgtctg       60

agttgtgccg cgagcgggtt tacccttagc aattactgga tgaactgggt acgtcaagct      120

ccaggtaaag gtttagaatg ggtcgctaac attaatcaag atggttctga acgctattat      180

gtagactcgg taaagggtcg ttttacaatt tctcgcgaca acgccaaaaa ctctttgtac      240

cttcaaatga attccttacg cgctgaggac actgctgtct atttctgtgc gcgtggaggg      300

gagggatacg gagttgacca ctatgggctg gacgtttcag gacagggcac tacggtaact      360

gtgtcttcg                                                              369


<210>  885
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  885
gaggttcagt tagtagagtc cgggggagga ctggtacaac ctgggggtag tttgcgtctg       60

tcttgtgcag ccagcggttt cacattgtct aactattgga tgaattgggt tcgtcaagcg      120

cctggcaagg gactggagtg ggttgcaaac attaatcaag atggcagcga gcgttattac      180

gtggactcag taaaagggcg cttcacgatt agccgcgata atgctaagaa ctccttatat      240

ctgcagatgt catctttgcg tgccgaggac acggcagttt actattgcgc acgtggtggc      300

gagggatacg gcgtggatca ctatggtttg gacgtatcgg gccaagggac taccgtgact      360

gtgtcctct                                                              369


<210>  886
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  886
gaggaggtac agcttgtcga gtctggcggt ggccttgtgc aaccgggggg ttctttacgt       60

ttatcctgtg ccgctacagg atttacgtta agcaactatt ggatgaactg ggtacgtcaa      120

gctccgggga aggggctgga atgggttgcc aatatcaatc aggatgggtc tgaacgctac      180

tacgttgatt ctgttaaggg tcgctttact atttcacgtg acaatgccaa gaacagtctt      240

taccttcaaa tgaactcgtt acgcgctgag gatactgctg tgtactactg tgcgcgcggc      300

ggagagggat acggtgtcga tcattatggg cttgacgtaa gcgggcaggg tacgacggtg      360

acggtatcat ca                                                          372


<210>  887
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  887
gaggtgcagt tagttgagag cggaggtggt ttagttcagc cggggggctc gcttcgcctg       60

tcgtgcgccg cctcgggatt cacattatca aactactgga tgaattgggt ccgccaggct      120

ccgggcaaag gtcttgagtg ggtggcgaac attaatcagg acgggagcga gcgttattac      180

gttgattcgg taaaaggacg tttcactatc agtcgtgaca acgctaaaaa ttccttgtac      240

ttacagatga actcacttcg tgctgaggac accgcagtgt actactgtgc tcgcggtggt      300

gaaggatacg gcgtcgatca ctacggcctt gatgtatcag gacaggggac tacagttacc      360

gtctcttcc                                                              369


<210>  888
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  888
gaggtgcagt tggtagagag tgggggtggc ctggtccaac caggtgggtc ccttcgtttg       60

tcttgcgccg cctctgggtt tactctgtca aattattgga tgaactgggt gcgccaagct      120

cccggcaagg ggttggagtg ggttgccaac attaatcagg acgaatccga gcgttactat      180

gttgattctg taaaagggcg cttcactatc tctcgtgata atgctaagaa cagtttgtac      240

ctgcaaatga attcactgcg tgccgaggat accgcggtgt actattgtgc ccgtggagga      300

gagggatacg gggtcgatca ctatggctta gacgtatcgg gccagggaac aaccgtcacc      360

gtatcctca                                                              369


<210>  889
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding bivalent molecule of Seq ID NO: 890

<400>  889
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt ggctatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcatat atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagatccg      300

gcctggggat tacgtttggg ggagtcatcg tcctatgatt ttgatatctg gggccaaggg      360

acaatggtca ccgtctcctc aggtggtggc ggttcaggcg gaggtggctc tggaggtgga      420

ggttcaggag gtggtggttc tggcggcggt ggatcgggtg gaggtggtag tgaggtgcag      480

ttagttgaga gcggaggtgg tttagttcag ccggggggct cgcttcgcct gtcgtgcgcc      540

gcctcgggat tcacattatc aaactactgg atgaattggg tccgccaggc tccgggcaaa      600

ggtcttgagt gggtggcgaa cattaatcag gacgggagcg agcgttatta cgttgattcg      660

gtaaaaggac gtttcactat cagtcgtgac aacgctaaaa attccttgta cttacagatg      720

aactcacttc gtgctgagga caccgcagtg tactactgtg ctcgcggtgg tgaaggatac      780

ggcgtcgatc actacggcct tgatgtatca ggacagggga ctacagttac cgtctcttcc      840

ggcggaggtg gctctggagg aggaggttca ggaggtggtg gatctggcgg cggtggtagt      900


<210>  890
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bivalent Molecule

<400>  890

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Ala Trp Gly Leu Arg Leu Gly Glu Ser Ser Ser Tyr 
            100                 105                 110         


Asp Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asn Tyr Trp Met Asn 
            180                 185                 190         


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asn Ile 
        195                 200                 205             


Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Asp Ser Val Lys Gly Arg Phe 
    210                 215                 220                 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn 
225                 230                 235                 240 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly 
                245                 250                 255     


Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val Ser Gly Gln Gly 
            260                 265                 270         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295             


<210>  891
<211>  858
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding bivalent molecule of seq ID NO.892

<400>  891
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcaagt attggtgaga atgatggtac cacagactac      180

gcagacgccg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctgcaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctcag gtggtggcgg ttcaggcgga      360

ggtggctctg gaggtggagg ttcaggaggt ggtggttctg gcggcggtgg atcgggtgga      420

ggtggtagtg aggtgcagtt agttgagagc ggaggtggtt tagttcagcc ggggggctcg      480

cttcgcctgt cgtgcgccgc ctcgggattc acattatcaa actactggat gaattgggtc      540

cgccaggctc cgggcaaagg tcttgagtgg gtggcgaaca ttaatcagga cgggagcgag      600

cgttattacg ttgattcggt aaaaggacgt ttcactatca gtcgtgacaa cgctaaaaat      660

tccttgtact tacagatgaa ctcacttcgt gctgaggaca ccgcagtgta ctactgtgct      720

cgcggtggtg aaggatacgg cgtcgatcac tacggccttg atgtatcagg acaggggact      780

acagttaccg tctcttccgg cggaggtggc tctggaggag gaggttcagg aggtggtgga      840

tctggcggcg gtggtagt                                                    858


<210>  892
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bivalent Molecule

<400>  892

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asn Tyr Trp 
                165                 170                 175     


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
            180                 185                 190         


Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val Ser 
                245                 250                 255     


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        275                 280                 285     


<210>  893
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding trivalent molecule of seq ID NO. 894

<400>  893
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt ggctatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcatat atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagatccg      300

gcctggggat tacgtttggg ggagtcatcg tcctatgatt ttgatatctg gggccaaggg      360

acaatggtca ccgtctcctc aggtggtggc ggttcaggcg gaggtggctc tggaggtgga      420

ggttcaggag gtggtggttc tggcggcggt ggatcgggtg gaggtggtag tgaggtgcag      480

ttagttgaga gcggaggtgg tttagttcag ccggggggct cgcttcgcct gtcgtgcgcc      540

gcctcgggat tcacattatc aaactactgg atgaattggg tccgccaggc tccgggcaaa      600

ggtcttgagt gggtggcgaa cattaatcag gacgggagcg agcgttatta cgttgattcg      660

gtaaaaggac gtttcactat cagtcgtgac aacgctaaaa attccttgta cttacagatg      720

aactcacttc gtgctgagga caccgcagtg tactactgtg ctcgcggtgg tgaaggatac      780

ggcgtcgatc actacggcct tgatgtatca ggacagggga ctacagttac cgtctcttcc      840

ggcggaggtg gctctggagg aggcggatcg gggggtggag gaagtggcgg cggtggtagt      900

ggaggaggtg gttctggagg cggtggctct gaagtacaac tggttgaatc gggtggtgga      960

ttggtccaac ctggaagatc attgaggctt tcttgtgcag cttccggatt cacctttcat     1020

cactatgcta tgcactgggt gagacaagcc cctggtaagg gcttggaatg ggtgtccgga     1080

atctcctgga atggtaacaa aataacatat gcagattccg ttaagggtag atttactatt     1140

agccgtgata atgcaaaaaa cagtttatac ttgcagatga attccttgag ggctgaggat     1200

acagctcttt actattgtgt gcgtgactca tcgttgttca ttgtcggagc cccaactttc     1260

gaacattggg gtagaggtac cctagttacg gttagctcag gcggaggtgg ctctggagga     1320

ggcggatcgg ggggtggagg aagtggcggc ggtggtagt                            1359


<210>  894
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trivalent molecule

<400>  894

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Ala Trp Gly Leu Arg Leu Gly Glu Ser Ser Ser Tyr 
            100                 105                 110         


Asp Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asn Tyr Trp Met Asn 
            180                 185                 190         


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asn Ile 
        195                 200                 205             


Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly 
                245                 250                 255     


Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val Ser Gly Gln 
            260                 265                 270         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
305                 310                 315                 320 


Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                325                 330                 335     


Phe Thr Phe His His Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly 
            340                 345                 350         


Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Trp Asn Gly Asn Lys Ile 
        355                 360                 365             


Thr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    370                 375                 380                 


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
385                 390                 395                 400 


Thr Ala Leu Tyr Tyr Cys Val Arg Asp Ser Ser Leu Phe Ile Val Gly 
                405                 410                 415     


Ala Pro Thr Phe Glu His Trp Gly Arg Gly Thr Leu Val Thr Val Ser 
            420                 425                 430         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        435                 440                 445             


Gly Gly Gly Gly Ser 
    450             


<210>  895
<211>  2634
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding trivalent molecule of Seq ID no. 896

<400>  895
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcaagt attggtgaga atgatggtac cacagactac      180

gcagacgccg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctacaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctcag gtggtggcgg ttcaggcgga      360

ggtggctctg gaggtggagg ttcaggaggt ggtggttctg gcggcggtgg atcgggtgga      420

ggtggtagtg aagtacaact ggttgaatcg ggtggtggat tggtccaacc tggaagatca      480

ttgaggcttt cttgtgcagc ttccggattc acctttcatc actatgctat gcactgggtg      540

agacaagccc ctggtaaggg cttggaatgg gtgtccggaa tctcctggaa tggtaacaaa      600

ataacatatg cagattccgt taagggtaga tttactatta gccgtgataa tgcaaaaaac      660

agtttatact tgcagatgaa ttccttgagg gctgaggata cagctcttta ctattgtgtg      720

cgtgactcat cgttgttcat tgtcggagcc ccaactttcg aacattgggg tagaggtacc      780

ctagttacgg ttagctcagg cggaggtggc tctggaggag gaggttcagg aggtggtgga      840

tctggaggag gcggatcggg gggtggagga agtggcggcg gtggtagtga ggtgcagtta      900

gttgagagcg gaggtggttt agttcagccg gggggctcgc ttcgcctgtc gtgcgccgcc      960

tcgggattca cattatcaaa ctactggatg aattgggtcc gccaggctcc gggcaaaggt     1020

cttgagtggg tggcgaacat taatcaggac gggagcgagc gttattacgt tgattcggta     1080

aaaggacgtt tcactatcag tcgtgacaac gctaaaaatt ccttgtactt acagatgaac     1140

tcacttcgtg ctgaggacac cgcagtgtac tactgtgctc gcggtggtga aggatacggc     1200

gtcgatcact acggccttga tgtatcagga caggggacta cagttaccgt ctcttccggc     1260

ggaggtggct ctggaggagg cggatcgggg ggtggaggaa gtggcggcgg tggtagtgag     1320

gtgcagctgt tggagtctgg gggaggcttg gtacagcctg gggggtccct gagactctcc     1380

tgtgcagcct ctggattcag ttttagcagc tatgccctca gttgggtccg ccaggctcca     1440

gggaaggggc tggagtgggt ttcaagtatt ggtgagaatg atggtaccac agactacgca     1500

gacgccgtga agggccgatt caccatctcc agagacaatt ccaagaatac gctgtatcta     1560

caaatgaaca gcctgagagt cgaggacacg gccgtctatt actgtgtgaa agatggtgtc     1620

cactggggcc agggaaccct ggtcaccgtc tcctcaggtg gtggcggttc aggcggaggt     1680

ggctctggag gtggaggttc aggaggtggt ggttctggcg gcggtggatc gggtggaggt     1740

ggtagtgaag tacaactggt tgaatcgggt ggtggattgg tccaacctgg aagatcattg     1800

aggctttctt gtgcagcttc cggattcacc tttcatcact atgctatgca ctgggtgaga     1860

caagcccctg gtaagggctt ggaatgggtg tccggaatct cctggaatgg taacaaaata     1920

acatatgcag attccgttaa gggtagattt actattagcc gtgataatgc aaaaaacagt     1980

ttatacttgc agatgaattc cttgagggct gaggatacag ctctttacta ttgtgtgcgt     2040

gactcatcgt tgttcattgt cggagcccca actttcgaac attggggtag aggtacccta     2100

gttacggtta gctcaggcgg aggtggctct ggaggaggag gttcaggagg tggtggatct     2160

ggaggaggcg gatcgggggg tggaggaagt ggcggcggtg gtagtgaggt gcagttagtt     2220

gagagcggag gtggtttagt tcagccgggg ggctcgcttc gcctgtcgtg cgccgcctcg     2280

ggattcacat tatcaaacta ctggatgaat tgggtccgcc aggctccggg caaaggtctt     2340

gagtgggtgg cgaacattaa tcaggacggg agcgagcgtt attacgttga ttcggtaaaa     2400

ggacgtttca ctatcagtcg tgacaacgct aaaaattcct tgtacttaca gatgaactca     2460

cttcgtgctg aggacaccgc agtgtactac tgtgctcgcg gtggtgaagg atacggcgtc     2520

gatcactacg gccttgatgt atcaggacag gggactacag ttaccgtctc ttccggcgga     2580

ggtggctctg gaggaggcgg atcggggggt ggaggaagtg gcggcggtgg tagt           2634


<210>  896
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trivalent molecule

<400>  896

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His His Tyr Ala 
                165                 170                 175     


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
            180                 185                 190         


Gly Ile Ser Trp Asn Gly Asn Lys Ile Thr Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Val 
225                 230                 235                 240 


Arg Asp Ser Ser Leu Phe Ile Val Gly Ala Pro Thr Phe Glu His Trp 
                245                 250                 255     


Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    290                 295                 300                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
305                 310                 315                 320 


Ser Gly Phe Thr Leu Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ala 
                325                 330                 335     


Pro Gly Lys Gly Leu Glu Trp Val Ala Asn Ile Asn Gln Asp Gly Ser 
            340                 345                 350         


Glu Arg Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Glu Gly Tyr Gly 
385                 390                 395                 400 


Val Asp His Tyr Gly Leu Asp Val Ser Gly Gln Gly Thr Thr Val Thr 
                405                 410                 415     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser 
        435                 


<210>  897
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding trivalent molecule of seq ID no. 898

<400>  897
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cagttttagc agctatgccc tcagttgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcaagt attggtgaga atgatggtac cacagactac      180

gcagacgccg tgaagggccg attcaccatc tccagagaca attccaagaa tacgctgtat      240

ctacaaatga acagcctgag agtcgaggac acggccgtct attactgtgt gaaagatggt      300

gtccactggg gccagggaac cctggtcacc gtctcctcag gtggtggcgg ttcaggcgga      360

ggtggctctg gaggtggagg ttcaggaggt ggtggttctg gcggcggtgg atcgggtgga      420

ggtggtagtg aggtgcagtt agttgagagc ggaggtggtt tagttcagcc ggggggctcg      480

cttcgcctgt cgtgcgccgc ctcgggattc acattatcaa actactggat gaattgggtc      540

cgccaggctc cgggcaaagg tcttgagtgg gtggcgaaca ttaatcagga cgggagcgag      600

cgttattacg ttgattcggt aaaaggacgt ttcactatca gtcgtgacaa cgctaaaaat      660

tccttgtact tacagatgaa ctcacttcgt gctgaggaca ccgcagtgta ctactgtgct      720

cgcggtggtg aaggatacgg cgtcgatcac tacggccttg atgtatcagg acaggggact      780

acagttaccg tctcttccgg cggaggtggc tctggaggag gcggatcggg gggtggagga      840

agtggcggcg gtggtagtgg aggaggtggt tctggaggcg gtggctctga agtacaactg      900

gttgaatcgg gtggtggatt ggtccaacct ggaagatcat tgaggctttc ttgtgcagct      960

tccggattca cctttcatca ctatgctatg cactgggtga gacaagcccc tggtaagggc     1020

ttggaatggg tgtccggaat ctcctggaat ggtaacaaaa taacatatgc agattccgtt     1080

aagggtagat ttactattag ccgtgataat gcaaaaaaca gtttatactt gcagatgaat     1140

tccttgaggg ctgaggatac agctctttac tattgtgtgc gtgactcatc gttgttcatt     1200

gtcggagccc caactttcga acattggggt agaggtaccc tagttacggt tagctcaggc     1260

ggaggtggct ctggaggagg cggatcgggg ggtggaggaa gtggcggcgg tggtagt        1317


<210>  898
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trivalent molecule

<400>  898

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Tyr 
            20                  25                  30          


Ala Leu Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Gly Glu Asn Asp Gly Thr Thr Asp Tyr Ala Asp Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Asp Gly Val His Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Asn Tyr Trp 
                165                 170                 175     


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 
            180                 185                 190         


Asn Ile Asn Gln Asp Gly Ser Glu Arg Tyr Tyr Val Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Arg Gly Gly Glu Gly Tyr Gly Val Asp His Tyr Gly Leu Asp Val Ser 
                245                 250                 255     


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    290                 295                 300                 


Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala 
305                 310                 315                 320 


Ser Gly Phe Thr Phe His His Tyr Ala Met His Trp Val Arg Gln Ala 
                325                 330                 335     


Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Trp Asn Gly Asn 
            340                 345                 350         


Lys Ile Thr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        355                 360                 365             


Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    370                 375                 380                 


Glu Asp Thr Ala Leu Tyr Tyr Cys Val Arg Asp Ser Ser Leu Phe Ile 
385                 390                 395                 400 


Val Gly Ala Pro Thr Phe Glu His Trp Gly Arg Gly Thr Leu Val Thr 
                405                 410                 415     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            420                 425                 430         


Gly Ser Gly Gly Gly Gly Ser 
        435                 


<210>  899
<211>  1359
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding trivalent molecule of seq ID no. 900

<400>  899
gaggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt ctccttcagt ggctatggca tgcactgggt ccgccaggct      120

ccaggcaagg gactggagtg ggtggcatat atatcatatg atggaagtaa taaatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gaaagatccg      300

gcctggggat tacgtttggg ggagtcatcg tcctatgatt ttgatatctg gggccaaggg      360

acaatggtca ccgtctcctc aggtggtggc ggttcaggcg gaggtggctc tggaggtgga      420

ggttcaggag gtggtggttc tggcggcggt ggatcgggtg gaggtggtag tgaagtacaa      480

ctggttgaat cgggtggtgg attggtccaa cctggaagat cattgaggct ttcttgtgca      540

gcttccggat tcacctttca tcactatgct atgcactggg tgagacaagc ccctggtaag      600

ggcttggaat gggtgtccgg aatctcctgg aatggtaaca aaataacata tgcagattcc      660

gttaagggta gatttactat tagccgtgat aatgcaaaaa acagtttata cttgcagatg      720

aattccttga gggctgagga tacagctctt tactattgtg tgcgtgactc atcgttgttc      780

attgtcggag ccccaacttt cgaacattgg ggtagaggta ccctagttac ggttagctca      840

ggcggaggtg gctctggagg aggaggttca ggaggtggtg gatctggagg aggcggatcg      900

gggggtggag gaagtggcgg cggtggtagt gaggtgcagt tagttgagag cggaggtggt      960

ttagttcagc cggggggctc gcttcgcctg tcgtgcgccg cctcgggatt cacattatca     1020

aactactgga tgaattgggt ccgccaggct ccgggcaaag gtcttgagtg ggtggcgaac     1080

attaatcagg acgggagcga gcgttattac gttgattcgg taaaaggacg tttcactatc     1140

agtcgtgaca acgctaaaaa ttccttgtac ttacagatga actcacttcg tgctgaggac     1200

accgcagtgt actactgtgc tcgcggtggt gaaggatacg gcgtcgatca ctacggcctt     1260

gatgtatcag gacaggggac tacagttacc gtctcttccg gcggaggtgg ctctggagga     1320

ggcggatcgg ggggtggagg aagtggcggc ggtggtagt                            1359


<210>  900
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trivalent molecule

<400>  900

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Pro Ala Trp Gly Leu Arg Leu Gly Glu Ser Ser Ser Tyr 
            100                 105                 110         


Asp Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
145                 150                 155                 160 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Arg 
                165                 170                 175     


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His His Tyr Ala Met His 
            180                 185                 190         


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile 
        195                 200                 205             


Ser Trp Asn Gly Asn Lys Ile Thr Tyr Ala Asp Ser Val Lys Gly Arg 
    210                 215                 220                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met 
225                 230                 235                 240 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Val Arg Asp 
                245                 250                 255     


Ser Ser Leu Phe Ile Val Gly Ala Pro Thr Phe Glu His Trp Gly Arg 
            260                 265                 270         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        275                 280                 285             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
305                 310                 315                 320 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                325                 330                 335     


Phe Thr Leu Ser Asn Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly 
            340                 345                 350         


Lys Gly Leu Glu Trp Val Ala Asn Ile Asn Gln Asp Gly Ser Glu Arg 
        355                 360                 365             


Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    370                 375                 380                 


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
385                 390                 395                 400 


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Glu Gly Tyr Gly Val Asp 
                405                 410                 415     


His Tyr Gly Leu Asp Val Ser Gly Gln Gly Thr Thr Val Thr Val Ser 
            420                 425                 430         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        435                 440                 445             


Gly Gly Gly Gly Ser 
    450             


<210>  901
<211>  122
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(122)
<223>  VH that binds to HSA

<400>  901

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Ser Cys Ala Ala Ser Gly Phe Thr Phe His His Tyr Ala 
            20                  25                  30          


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
        35                  40                  45              


Gly Ile Ser Trp Asn Gly Asn Lys Ile Thr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Val 
                85                  90                  95      


Arg Asp Ser Ser Leu Phe Ile Val Gly Ala Pro Thr Phe Glu His Trp 
            100                 105                 110         


Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  902
<211>  750
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(750)
<223>  Nucleotide encoding VH that binds to HSA of Seq ID 901

<400>  902
ggctttgtga gcggatacaa ttataatatg tggaattgtg agcgctcaca attccacaac       60

ggtttccctc tagaaataat tttgtttaac ttttaggagg taaaacatat gaagaaaacg      120

gcaatcgcaa tcgcagtcgc tctggcgggt ttcgcaactg tagcgcaagc cgaggtgcaa      180

ctggtcgagt ctggtggtgg tttggtgcaa cctggtagaa gcttgcgttt gagttgtgcc      240

gcttccggct tcactttcca tcattatgct atgcactggg ttcgtcaagc tcccggaaaa      300

ggtttggagt gggtttccgg aatttcctgg aatggcaata agattacgta cgctgattca      360

gtgaaaggaa ggtttacaat cagtagagat aatgctaaaa actcattgta tctacaaatg      420

aacagcctaa gagcagaaga taccgctctg tactactgtg ttagagatag ctcgttattc      480

attgtaggtg caccaacttt tgaacattgg ggtcggggta ctcttgtgac tgtctcatcc      540

gcggccgcac accaccatca tcaccactaa ctcgagcgcc taatgaaagc ttccccaagg      600

gcgacacccc ctaattagcc cgggcgaaag gcccagtctt tcgactgagc ctttcgtttt      660

atttgatgcc tggcagttcc ctactctcgc atggggagtc cccacactac catcggcgct      720

acggcgtttc acttctgagt tcggcatgga                                       750


